Register or Submit a manuscript.
Table of Content

Open Access Original Research

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

Received: 02 June 2019;  Published: 19 August 2019;  doi: 10.21926/obm.transplant.1903079

Abstract

Background: T follicular helper (Tfh) and regulatory (Tfr) cells are key players in the formation of long-lived antibody responses. Their circulating counterparts, cTfh and cTfr, are often used as biomarkers because longitudinal sampling of secondary lymphoid tissues is unfeasible in clinical studies. This is the first study to track cTfh and cTfr cells following therapeutic lymphocyte depletion with alemtuzumab, an anti-CD52 monoclonal antibody, to infer the influence of this treatment on the germinal centre respo [...]

1765 10697

Open Access Review

Shedding Light on Manic Syndromes and Dementia

Received: 27 March 2019;  Published: 16 August 2019;  doi: 10.21926/obm.geriatr.1903070

Abstract

Background: Mania in older adults is associated with a high rate of medical and neurological disease. Objective: The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, late-onset, mania, and elderly. Publications found through this indexed search were reviewed for further relevant references. Resultsan [...]

2265 37370

Open Access Review

Advanced Endoscopic Techniques in the Evaluation and Treatment of Fibrostenotic Crohn's Disease

Received: 09 May 2019;  Published: 16 August 2019;  doi: 10.21926/obm.hg.1903033

Abstract

Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring or penetrating disease. While the utility of esophagogastroduodenoscopy and ileocolonoscopy in inflammatory bowel disease patients is well established, new endoscopic techniques are being developed to help evaluate prev [...]

1479 6707

Open Access Research Article

BSA-Embedded Carbonate Apatite Enhances Chemotherapeutic Effect of Paclitaxel in vitro and in vivo

Received: 29 March 2019;  Published: 15 August 2019;  doi: 10.21926/obm.genet.1903090

Abstract

Introduction of biocompatible ingredients into nano-material formulations has been studied as a strategy for the enhancement of the pharmacokinetics as well as pharmacodynamics of the final product. With the aim of enhancing drug loading and the ultimate efficacy, incorporation of Bovine Serum Albumin (BSA) into carbonate apatite (CA) nanoparticles structure was employed in the present study. As a result of BSA embedding in the CA formulation, approximately three-times higher loading efficiency was achieved for pac [...]

1964 9561

Open Access Review

Diagnosis and Treatment of Mitochondrial Abnormalities in Reproductive Medicine

Received: 08 April 2019;  Published: 14 August 2019;  doi: 10.21926/obm.genet.1903089

Abstract

Mitochondrial diseases are among the most prevalent inborn errors of metabolism. The overwhelming majority of mitochondrial diseases (about 85%) result from mutations in nuclear genes involved in oxidative phosphorylation, while some (15%) are caused by mutations in mitochondrial DNA (MtDNA). The familial mtDNA mutations are exclusively inherited from the mother. There are four main methods available to prevent the transmission of mtDNA mutations: preimplantation genetic diagnosis (PGD) or prenatal diagnosis (PND) [...]

1897 11166

Open Access Review

Conventional and Future Therapies for Crohn's Disease

Received: 20 May 2019;  Published: 14 August 2019;  doi: 10.21926/obm.hg.1903032

Abstract

Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications and slowing disease progression. No cure currently exists for the disease. Traditionally, the clinical approach to treatment has been symptom-based where patients have had to ‘earn’ their next treatment escalation. Howe [...]

1433 8960

Open Access Research Article

Immunoprotective Encapsulation of Micro-Organs

Received: 07 May 2019;  Published: 14 August 2019;  doi: 10.21926/obm.transplant.1903078

Abstract

Background: Cell encapsulation technology is most likely the ultimate solution for cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct is to consider not only the nature of the capsule but also how the cells should be incorporated into the capsule in order to minimally compromise their function. Methods: We have developed a tissue engineering approach, composed of decellularized micro scaffolds and various types of cells in which fully functional "Engineered Micro [...]

1582 9225

Open Access Original Research

Intranasal Insulin in Alzheimer’s Disease: A Pragmatic Account

Received: 15 March 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903069

Abstract

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and early to moderate Alzheimer’s Disease (AD) in the domains of jokes, self-expression and empathy after extended, targeted intranasal insulin therapy. In this paper it is argued that extended intra-nasal insulin treatment can [...]

2104 11009

Open Access Review

The Value Given and Presupposed in Person-Centred Dementia Care

Received: 08 April 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903068

Abstract

Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the standing or status bestowed on one human being by others in the context of relationships and social being and held that respect for the absolute value of each person is a key theme in Western ethical discourse. He was clear thi [...]

2614 22261

Open Access Original Research

Differential Effects of Social Network on Health in Later Life and the Moderating Role of Depression

Received: 23 March 2019;  Published: 12 August 2019;  doi: 10.21926/obm.geriatr.1903067

Abstract

Background: Differential effects of the characteristics of social network on limitations with activities (LWA) and the quality of life (QOL) among older adults, and the moderating role of depression were studied. Methods: The data obtained from two consecutive waves of the Survey of Health, Aging, and Retirement in Europe (SHARE) was examined. Results: Emotional closeness, satisfaction with the social network, and contact frequency were able to predict the QOL and not LWA. Moreover, depression was observed to moder [...]

1626 11083

Open Access Review

New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature

Received: 25 February 2019;  Published: 12 August 2019;  doi: 10.21926/obm.hg.1903031

Abstract

Crohn's Disease (CD) is a chronic inflammatory, relapsing and remitting condition that leads to structural damage of the bowel wall. It can be located in any part of the gastrointestinal tract with associated extra-intestinal manifestations. It varies in severity having many complications resulting in significant morbidity. In the past decade medical management of CD has evolved rapidly and with ongoing research it continues to show promising novel therapies. In this article we aim to give an overview of current li [...]

1534 7475

Open Access Review

Next-Generation Sequencing-Based Testing in Diagnostic Oncohematology: Untangling the Knots

Received: 01 April 2019;  Published: 09 August 2019;  doi: 10.21926/obm.genet.1903088

Abstract

With the advent of next-generation sequencing (NGS), genomic profiling of tumors has been gradually introduced into the clinical setting and has become a standard in cancer care. NGS allows convenient, rapid, and inexpensive sequencing and the commercially available NGS panels enable the detection of single or global genomic alterations of germline and somatic origin. Today, genomic mutation profiling using NGS is indispensable for disease evaluation and prediction of prognosis or responsiveness to cancer therapy. [...]

2068 13465

Open Access Case Report

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Received: 08 April 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903066

Abstract

The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a ‘personalised medicine’ approach challenges this view. This paper reviews the current evidence for dementia prevention utilising such treatments and explains the logic of applying personalised medicine. The functional medicine treatment approach to ‘root cause’ analysis is presented as currently practiced with patients experiencing cognitive [...]

2917 32410

Open Access Review

A Model for Understanding Hispanic/Latino Family Caregiving for Older Adults

Received: 19 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903065

Abstract

Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families for care. Methods: Review published caregiving models for older adults in H/L populations. Results: Gradual and inevitable acculturation of H/L caregivers to U.S. social customs, and the mutual relationship within the [...]

1873 13841

Open Access Short Report

Walk with Me

Received: 14 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.icm.1903050

Abstract

The author writes a genuine story using a narrative medicine writing style [1]. She relates how she applied mindfulness awareness and meditation practices to accompany her best friend, Abigail (Abigail is a pseudonym), who struggled through stages 3 and 4 breast cancer, including its noxious treatments and upsetting side effects. Clinical practice can be enhanced with narrative competence in that it helps the author recognize, interpret and be touched by patients’ stories, including all aspects of illness experienc [...]

2120 9481

Open Access Original Research

Sustainability Assessment of Power Generation from an Abandoned Oil and Gas Well in Alberta, Canada

Received: 30 May 2019;  Published: 07 August 2019;  doi: 10.21926/jept.1903002

Abstract

The main objective of this paper is to study the sustainability of power generation from an abandoned oil and gas well in the province of Alberta, Canada. Economic and environmental indicators were used for the sustainability assessment. A conceptual design for a pilot plant was developed, and the main parameters were determined. An abandoned oil and gas well represents the thermal power source through circulating water into an organic Rankine cycle (ORC) unit to generate electricity. The thermal power is extracted [...]

2277 14315

Open Access Project Report

Evaluation of Polymer Dispersed Liquid Crystal (PDLC) for Passive Rear Projection Screen Application

Received: 24 June 2019;  Published: 07 August 2019;  doi: 10.21926/rpm.1903002

Abstract

In the past few years, there have been many attempts to commercialize Polymer Dispersed Liquid Crystal (PDLC) for Rear Projection Screen (RPS) in electrically switchable films and glass products. This application is based on the exceptional image quality of PDLC at a wide viewing angle. However, due to the high price of conventional switchable PDLC privacy glass, the integration of RPS in PDLC failed to attract large multimedia and entertainment markets. An obvious solution to this problem is the independent develo [...]

3364 23646

Open Access Original Research

Mortality Risk Factors in Patients who are in Heart Transplantation Waiting List

Received: 01 February 2019;  Published: 05 August 2019;  doi: 10.21926/obm.transplant.1903077

Abstract

Background: To estimate the survival of patients in the heart transplantation waiting list (HTx WL) at Almazov National Medical Research Centre (V.A. Almazov NMRC), Saint-Petersburg, Russia, from 2010 to 2017 and to define risk factors for death among these patients. Methods: It was a single-center retrospective study involving 151 patients with advanced chronic heart failure (CHF) in the HTx WL. Results: Mortality in the HTx WL for the period 2010-2017 was found to decrease. Based on the results of constructing th [...]

1660 9731

Open Access Review

A Review of Factors Affecting the Acute Exercise-Cognition Relationship in Children and Adolescents

Received: 29 April 2019;  Published: 02 August 2019;  doi: 10.21926/obm.icm.1903049

Abstract

It is well documented that an acute bout of exercise has a positive effect on subsequent cognitive function in children and adolescents. However, the effect of: the exercise characteristics (i.e. intensity, duration and modality), the cognitive domain assessed, and moderating variables (such as the participant’s age, physical fitness and baseline cognitive abilities); all of which affect this relationship are poorly understood. Therefore, the purpose of this review is to examine the impact of these variables on the [...]

2287 13436

Open Access Original Research

Characterisation of Oxidative Stress, DNA Damage and Inflammation in a Cellular Model of Parkinson’s Disease

Received: 13 March 2019;  Published: 01 August 2019;  doi: 10.21926/obm.neurobiol.1903036

Abstract

Background: Parkinson's disease (PD) is the second most common neurodegenerative disease and is a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage. Methods: SH-SY5Y cells were stably transfected with plasmids containing wild type (WT) α-Syn and A53T mutant α-Syn as fusion proteins with EGFP and an EGFP only control vector. The cells were differentiated using retinoi [...]

2078 13283

Open Access Review

Pathological Angiogenesis: The New Culprit behind Chronic Liver Disease

Received: 25 February 2019;  Published: 31 July 2019;  doi: 10.21926/obm.hg.1903030

Abstract

This review describes our current understanding of the pathogenic role of angiogenesis in chronic liver disease and portal hypertension, emphasizing its involvement not only in the liver but also in extrahepatic complications such as the formation of portosystemic collaterals and increased splanchnic blood flow, and highlighting different molecular and cellular mechanisms involved.

1260 7542

Open Access Review

Pancreatitis in Solid Organ Transplant Patients: A Review of the Literature

Received: 05 May 2019;  Published: 29 July 2019;  doi: 10.21926/obm.hg.1903029

Abstract

Acute pancreatitis is a highly morbid condition widely recognized and well-defined in the general population. In this article, we summarize the current literature on acute pancreatitis in the setting of solid organ transplant axiom, including patients who are listed for or have undergone transplantation. The literature is summarized by organ transplant type, including cardiac, lung, pancreas, kidney, intestine, and liver. Our review suggests that providers should have a high index of suspicion for acute pancreatiti [...]

1429 10560

Open Access Review

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Received: 07 May 2019;  Published: 29 July 2019;  doi: 10.21926/obm.neurobiol.1903035

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury, and its mechanisms have not been completely unraveled so far. The causative factors for the brain injury initiated by an aneurysm rupture, which is referred to as the early brain injury (EBI), include elevated intracranial pressure, cerebral hypoperfusion, and blood contents that are directly exposed to the brain surface. At Day 4–14 post aSAH, delayed cerebral ischemia (DCI) often develops, which may worsen the neurological outcomes critically. [...]

1944 12177

Open Access Research Article

Never Say Never: Unexpected Pulmonary Pathogens Found on Autopsy in Hematopoietic Cell Transplantation Recipients

Received: 03 June 2019;  Published: 29 July 2019;  doi: 10.21926/obm.transplant.1903076

Abstract

Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a series of five cases of Candida pneumonia and five cases of enterococcal pneumonia found on autopsy in hematopoietic cell transplantation recipients. We will also review the literature regarding the epidemiology, risk facto [...]

1298 11219

Open Access Research Article

Family History, Genetic, and Other Cause-Related Beliefs among Breast Cancer Survivors

Received: 27 February 2019;  Published: 26 July 2019;  doi: 10.21926/obm.genet.1903087

Abstract

Patients’ lay theories about the cause of their cancer may influence patient behavior and adjustment, they have also been found to differ substantially from scientific evidence of cancer risk factors. This report describes beliefs about genetic causes of breast cancer, among 522 recently diagnosed breast cancer survivors participating in an observational study. Patients were asked to respond to an open-ended question about the cause of their cancer. Causes mentioned included family history, genetics, lifestyl [...]

1966 10161

Open Access Review

Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Received: 05 April 2019;  Published: 26 July 2019;  doi: 10.21926/obm.transplant.1903075

Abstract

The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for their dimorphic life cycle, specific geographic distributions, and typical infection via environmental exposure. Their nonspecific presentation can make diagnosis challenging. Because of their geographic associations, assessment of both donor and recipient history is critical in making an accurate and timely diagnosis. Coccidioides spp. are endemic to the southwestern United S [...]

1999 16335

Open Access Comment

Compassion in a Doctor-Patient Relationship: Objectively Measuring Compassionate Behavior Using the Emotional Availability (EA) Scales

Received: 13 March 2019;  Published: 25 July 2019;  doi: 10.21926/obm.icm.1903048

Abstract

Most research on compassion utilizes self-report measures. Subjective report of the individual can provide an authentic window about compassion toward the self. Compassionate behavior toward another person, on the other hand, can and should be measured more objectively than self-report allows. Compassionate behavior toward another can best be measured by how that individual actually interacts with others. In this essay, we will describe how behavior that is compassionate can be objectively measured, and one that ha [...]

2279 12488

Open Access Opinion

How to Heal the Healer: Combating Burnout Using Compassion and Mindfulness-Based Interventions

Received: 13 June 2019;  Published: 24 July 2019;  doi: 10.21926/obm.icm.1903047

Abstract

We explore how medical culture contributes to burnout. Highlighting specific programs aimed at developing compassion and mindfulness skills, we share our own perspectives and experiences implementing similarly focused programs. Promising results on the application of compassion-based programs show evidence of improvements to a number of measures of trainee wellbeing, particularly among the most vulnerable trainees, while results pertaining to mindfulness programs show improvements to performance as well [1, 2]. As [...]

1920 9120

Open Access Review

Our Steps toward Subcutaneous Transplantation of Macro-Encapsulated Islets

Received: 29 May 2019;  Published: 24 July 2019;  doi: 10.21926/obm.transplant.1903074

Abstract

Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, recent clinical trials show that micro-encapsulated islets are not fully retrievable after transplantation. By contrast, macro-encapsulated islets can be retrieved when necessary. As to the transplantation site, subcutaneous tissue can be promising, if new [...]

1657 11604

Open Access Original Research

The Evolution of DNA Typing in Agri-Food Chain

Received: 11 June 2019;  Published: 23 July 2019;  doi: 10.21926/obm.genet.1903086

Abstract

Background: DNA typing has revolutionized not only diagnostics and forensics but also how we can analyze food. A number of techniques have been successfully applied for DNA analysis of plant-derived food. However, unlike forensics, a universally employed method has not yet emerged. Methods: A keyword-based search was performed using the ISI-Web of Science database to look for research articles on DNA testing in agri-food chain. After screening and eligibility check, a Systematic Review was compiled focusing on the [...]

1880 10680

Open Access Original Research

A Techno-Economic Feasibility Analysis for the Production of Solar Photovoltaic Modules in Sudan

Received: 23 May 2019;  Published: 23 July 2019;  doi: 10.21926/jept.1903001

Abstract

This paper is intended to evaluate the economic viability of producing solar photovoltaic modules in Sudan. The simple payback period and the net present value were used as economic indicators to study comparatively different annual production capacities. Initial and operating costs were developed and analyzed for the product lifecycle. The number of working shifts in the base case is doubled to achieve a production rate of 20 MW/year and double shift with double quantity of machines is executed to reach a producti [...]

2235 15490

Open Access Case Report

Constitutional Partial Proximal Trisomy 14q11.2 to 14q21: Two New Moroccan Cases and Review of the Literature

Received: 25 July 2018;  Published: 22 July 2019;  doi: 10.21926/obm.genet.1903085

Abstract

Background: A report of two new Moroccan cases with polymalformative syndrome, in which we identified similar but not identical sSMCs derived from chromosome 14. Methods: Conventional karyotype and MULTI-FISH. Results: +del(14)(q21.1) in the first case and +del(14)(q21.2) in the second. Conclusions: Constitutional partial trisomy 14 has an expanded clinical spectrum as one case from the literature was associated with gonadal tumor development. Similar cases, including the ones reported here, need to be carefully fo [...]

2365 11834

Open Access Review

Preimplantation Genetic Testing for HLA-matching: An Overview of Clinical Application and Utility

Received: 03 June 2019;  Published: 22 July 2019;  doi: 10.21926/obm.genet.1903084

Abstract

Preimplantation Genetic Testing for HLA-matching (PGT-HLA) has been one of the most controversial PGT applications, first reported in 2001. The procedure aims to identify an embryo that is not only healthy but also HLA-matched with a sibling in the family in need of haematopoietic stem cell transplantation (HSCT), considering that sibling HSCT stands the highest chance of success in comparison to alternative approaches. HLA-typing can be performed with or without PGT-M for the exclusion of a single-gene disorder. T [...]

2280 21613

Open Access Review

Short Sleep in Pupils in Japan: Current Status and Associated Factors

Received: 21 February 2019;  Published: 22 July 2019;  doi: 10.21926/obm.neurobiol.1903034

Abstract

Background: Several recommendations on optimum sleep duration have been published for adolescents to secure a healthy life. This study aimed to compare the sleep duration of middle and high school pupils in Japan with the recommended values and determined the factors associated with the duration of sleep among them. Methods: A total of 1766 completed questionnaires were obtained from grades 7 to 12 pupils in Japan. The questionnaire addressed the following points: sleeping, eating, defecation, physical activity, sc [...]

1730 16693

Open Access Review

Hereditary Pancreatitis – A Review of Current Concepts and Management

Received: 30 April 2019;  Published: 19 July 2019;  doi: 10.21926/obm.hg.1903028

Abstract

(1) Background: Hereditary Pancreatitis is a rare cause of acute pancreatitis. These patients usually present at a young age with recurrent episodes of acute pancreatitis that usually progresses to chronic pancreatitis with associated endocrine and exocrine failure. Hereditary pancreatitis also carries an increased lifetime risk of pancreatic adenocarcinoma. These high risk patients need early intervention where appropriate by specialist multidisciplinary teams and tailored long term management. (2) Methods [...]

1311 8292

Open Access Review

Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5

Received: 05 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.geriatr.1903064

Abstract

The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided much understanding of molecular and cellular biology, as well as insights into many human diseases. In this paper we review how yeast studies are contributing to knowledge about the role of oxidative damage to cell health, and how one of the key players in Alzheimer’s disease, amyloid beta (Aβ) is linked to the reactive oxygen species response involving AHP1, which encodes an alkyl hydroperoxidase, Ahp1p, a protein involved in protect [...]

1974 10125

Open Access Original Research

Melatonin Aggravated Oxaliplatin-Mimicking Sinusoidal Obstruction Syndrome: Role of Platelet Aggregation and Oxidative Stress

Received: 31 March 2019;  Published: 17 July 2019;  doi: 10.21926/obm.neurobiol.1903033

Abstract

Background: Sinusoidal obstruction syndrome is caused by an injury to the liver induced either by accidental ingestion of pyrrolizidine alkaloid monocrotaline or by chemotherapeutic drug oxaliplatin used for the treatment of colorectal cancer. Sinusoidal obstruction syndrome is characterized by rounding and swelling of the sinusoidal endothelial cell, which leads to obstruction of blood vessels, leukocyte infiltration, and oxidative stress. Melatonin, a powerful antioxidant, prevents acute liver injury. We investig [...]

1816 48042

Open Access Review

Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Received: 05 December 2018;  Published: 17 July 2019;  doi: 10.21926/obm.transplant.1903073

Abstract

Background: Infants and children undergoing liver transplant require ongoing nutritional evaluation throughout the pre and post-transplant period. The pathophysiologic causes of chronic liver disease and acute liver failure are varied, and each present different and unique nutritional challenges. Methods: A review of the literature and Seattle Children's established guidelines for nutritional management of pediatric liver transplant patients was conducted. Results: We present guidelines of care to optimize nutritio [...]

2746 23241

Open Access Review

Single Cell Transcriptomic Analysis of Pancreatic β Cell Development and Differentiation from Pluripotent Stem Cells

Received: 06 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.transplant.1903072

Abstract

Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represent an ideal tissue type for single cell transcriptomic analysis. Adult human islets consist of five known endocrine cell types (α, β, δ, γ, ε) and multiple less well-defined non-endocrine cells. In this review, we discuss [...]

2140 15014

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Received: 12 June 2019;  Published: 16 July 2019;  doi: 10.21926/obm.geriatr.1903063

Abstract

Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a century of pharmacological failures in stopping or slowing the disease, there is a need to examine how the simplified cause evolved and to explore alternate approaches to understanding Alzheimer’s disease. Going beyond the nar [...]

2024 10409

Open Access Review

Therapeutic Strategies and Current Management for Hepatic Encephalopathy in Liver Cirrhosis

Received: 04 February 2019;  Published: 16 July 2019;  doi: 10.21926/obm.hg.1903027

Abstract

Hepatic encephalopathy (HE) is a neuropsychiatric syndrome showing a wide spectrum and one of the serious complications seen in patients with acute and chronic liver disease or spontaneous portal-systemic shunting. Recently, HE has been classified into two categories: covert HE, which involves minimal HE and is identified solely through psychometric or neurological tests, and overt HE (coma grade II-IV). Although recent therapies based on evidence-based results have improved the therapeutic outcomes of HE patients, [...]

1461 9037

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Received: 28 March 2019;  Published: 15 July 2019;  doi: 10.21926/obm.geriatr.1903062

Abstract

Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia benefit from reduction of their non-cognitive, behavioural changes, enhancement of their cognitive capacities and being socially active. Methods: The current study represents a narrative general literature review on availabl [...]

2497 18740

Open Access Communication

Photobiomodulation Therapy (PBMT) as a Complementary Medicine for Women to Adjust Their Autonomic Nervous Systems and Induce Specific Brain Waves - A Case Report

Received: 04 March 2019;  Published: 15 July 2019;  doi: 10.21926/obm.icm.1903046

Abstract

Sleep has played a critical role in maintaining the physical and psychological health of humans, especially for women. Many studies reveal that sleep disturbance can cause more inflammation, coagulation, insulin resistance, and psychosocial distress in women than in men. A lot of medications are used to treat sleep disorders, but they can cause various adverse effects. Photobiomodulation therapy (PBMT) has been proved as a safe and easy-to-use therapy. We propose two methods of affecting the autonomic nervous syste [...]

2055 12149

Open Access Review

Review of Current Evidence in Acute Pancreatitis

Received: 17 May 2019;  Published: 12 July 2019;  doi: 10.21926/obm.hg.1903026

Abstract

Acute pancreatitis (AP) is an inflammatory condition of the pancreas and is one of the most common ailments of the gastrointestinal system that results in significant morbidity and mortality. The main etiologic causes of AP are alcohol consumption, gallstones, hypertriglyceridemia, and biliary stones. The clinical signs and symptoms, and diagnostic criteria of AP are well established in the literature and multiple studies. Multiple scoring systems have been used to predict the severity, prognosis, and mortality a [...]

1292 6981

Open Access Review

Breath Practices for Survivor and Caregiver Stress, Depression, and Post-traumatic Stress Disorder: Connection, Co-regulation, Compassion

Received: 10 April 2019;  Published: 12 July 2019;  doi: 10.21926/obm.icm.1903045

Abstract

Does compassion itself benefit the healing process or does the activation of neurophysiological processes, from which the experience of compassion arises, trigger a cascade of physical and psychological changes that support health and well-being? Exploration of the neurological substrates of compassion reveals multiple healing pathways that can be activated by mind-body practices. Furthermore, these pathways affect physical health, emotion regulation, and how we perceive and relate to others. Physiological states a [...]

4354 42772

Open Access Original Research

Genes Coding for GPI Biosynthesis in Pneumocystis Experienced Relaxed Selection: A Follow-up Study

Received: 05 May 2019;  Published: 11 July 2019;  doi: 10.21926/obm.genet.1903083

Abstract

Background: Phylogenetic analysis shows that Pneumocystis have coevolved with their mammalian hosts for millions of years. As a result, infection by Pneumocystis is species specific (i.e. a given Pneumocystis species can infect only a single species of host). This specificity suggests the existence of a Red-Queen dynamic between Pneumocystis and its host. Evidence of this dynamic is provided by the molecular diversity and the elevated rate of non-synonymous versus synonymous (dN/dS) codon substitutions among Pneumo [...]

2162 11763

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Received: 19 February 2019;  Published: 09 July 2019;  doi: 10.21926/obm.geriatr.1903061

Abstract

Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on short notice and in emergencies. Methods: This study used city government survey results on service user satisfaction with the Japanese Long-Term Care Insurance (LTCI) system for a mid-sized, Japanese city. From this a range [...]

1840 14544

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Received: 27 March 2019;  Published: 09 July 2019;  doi: 10.21926/obm.transplant.1903071

Abstract

Background: The existing non-human primate diabetic models, particularly those induced by total pancreatectomy or streptozotocin (STZ) injection, have several disadvantages, including a lengthy surgical procedure, the need for continual supplementation of digestive enzymes, and delayed oral intake after total pancreatectomy, and severe hypoglycemia and hepatic/renal toxicity following injection of high-dose STZ. This study aimed to develop and optimize a non-human primate diabetic model that would avoid the disadva [...]

1757 12318

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Received: 30 March 2019;  Published: 08 July 2019;  doi: 10.21926/obm.geriatr.1903060

Abstract

The understanding of mental deterioration associated with old age has undergone several changes over the past two centuries, and has spurred major scientific debates. In the 19th century, this disorder was still considered an inevitable part of aging. The beginning of the 20th century offered a histological explanation for presenile dementia, and Alois Alzheimer was credited as the discoverer of a new disease that bears his name to date. In the last quarter of the 20th century, findings of Alois Alzheimer were appl [...]

1704 10871

Open Access Commentary

Compassion in Medical Practice

Received: 25 April 2019;  Published: 08 July 2019;  doi: 10.21926/obm.icm.1903044

Abstract

Compassion and kindness can be cultivated and enhanced. Over the years in medical practice I have witnessed many healthcare workers, after having worked with kind and caring practitioners, become progressively more humane. Those of us who are teachers need to be mindful of that. In educating new physicians, compassion should play a central role and we as practicing doctors are well placed to model a caring and empathetic approach to our patients. There is also a fundamental need to look after ourselves and main [...]

2127 9053

Open Access Review

Complementary and Alternative Medicine (CAM) Usage in Breast Cancer

Received: 27 February 2019;  Published: 05 July 2019;  doi: 10.21926/obm.icm.1903043

Abstract

Background: In particular, the women with breast cancer seek methods offered by complementary and alternative medicine (CAM). Unfortunately, the value of most of such methods remains unclear. Methods: The present review was aimed at identifying reasonable strategies for patients with breast cancer on the basis of the current literature. Results: The analyses revealed that there is no evidence of alternative medicine which might result in healing. However, several strategies are available which could improve patient [...]

2123 10010

Open Access Original Research

Assessing the Impact of a Game-Centered Mobile App on Community-Dwelling Older Adults’ Health Activation

Received: 11 April 2019;  Published: 04 July 2019;  doi: 10.21926/obm.icm.1903041

Abstract

Background: Older adults experience normative age-graded declines in physical and cognitive performance and many must manage one or more chronic conditions. Exercise programs can help to improve both their physical health and their knowledge, skill, and confidence in managing aspects of their own healthcare, yet a significant barrier is motivating them to adhere to such programs. The purpose of this investigation was to evaluate the impact of a game-centered mobile app (Bingocize®) on older adults' knowledge [...]

2525 14388

Open Access Original Research

Effect of Acute Moderate-Intensity Exercise on Autobiographical Episodic Memory and Semantic Memory

Received: 27 April 2019;  Published: 04 July 2019;  doi: 10.21926/obm.icm.1903042

Abstract

Background: The objective of this study was to evaluate the effects of acute moderate-intensity exercise on autobiographical episodic memory and semantic memory. Methods: A two-arm, parallel-group randomized controlled intervention was employed. The experimental group engaged in an acute bout of treadmill exercise for 15 minutes (70% of heart rate max), while the control group engaged in a time-matched seated activity. For episodic autobiographical memory, participants recalled as many personal memories of events f [...]

2084 10997

Open Access Research Article

Daytime Sleepiness and the Well-Being and Academic Attainment of University Students in the UK

Received: 02 April 2019;  Published: 02 July 2019;  doi: 10.21926/obm.neurobiol.1903032

Abstract

Background: Previous research suggests that insufficient daily sleep has negative effects on both well-being and academic attainment. Much of the research in this field has focused on adolescents and children rather than university students in the UK. Methods: The present study used the Student Well-Being Process Questionnaire and independent sleep questions to measure subjective well-being and levels of sleep in a student sample (N=345) who completed the survey online. Academic attainment was measured with exam an [...]

2053 13501

Open Access Review

Nonalcoholic Fatty Liver Disease and Inflammatory Bowel Disease: Complex Interactions, Evaluations, and Management Decisions

Received: 31 January 2019;  Published: 28 June 2019;  doi: 10.21926/obm.hg.1902025

Abstract

Diseases of the liver are commonly encountered in patients with Inflammatory Bowel Disease (IBD). While the differential for IBD patients with elevated liver associated enzymes is broad, it is similar to that of the general population. This differential includes including non-alcoholic fatty liver disease (NAFLD), the most common liver disease in North America. When initial work-up for elevated liver associated enzymes is negative and patients have steatosis on ultrasound, we counsel IBD patients aggressively about [...]

1202 7662

Open Access Case Report

Case Series of Multiple Health Benefits in Those Undertaking Extended Qigong Practice as a Complementary Self-care Practice in an Outpatient Pain Clinic

Received: 01 April 2019;  Published: 28 June 2019;  doi: 10.21926/obm.icm.1902040

Abstract

Background: Qigong, traditional Chinese mind-body practices, is currently receiving increasing attention with exploration of what it is and what it does. Common elements include postures and movement, attention to breathing, and mental instructions. There is a growing literature on the health benefits of qigong in chronic pain and other conditions, and an intervention that provides benefit in multiple domains is particularly important for clinical practice. In this report, we present a case series of six individual [...]

1864 10364

Open Access Communication

A Neurotransmitter Approach to the Trolley Problem

Received: 25 February 2019;  Published: 28 June 2019;  doi: 10.21926/obm.neurobiol.1902030

Abstract

Is it ethically permissible to sacrifice the life of one human being in order to save the lives of five others? This question forms the basis of the famous thought experiment called “the trolley problem.” Surveys have found that 90 percent of people agree it is permissible when the victim to be sacrificed is described as off in the distance, whereas the opposite result occurs if the victim is described as up close. No consistent ethical principle has been identified that account for these results. In this paper we [...]

2429 17689

Open Access Research Article

Autonomic Function Correlates with Microflora Compositions in a Small Cohort of Patients with Autism Spectrum Disorder: Preliminary Clinical Data and Discussion

Received: 05 March 2019;  Published: 28 June 2019;  doi: 10.21926/obm.neurobiol.1902031

Abstract

Background: Research into the effects of microflora on health and in disease has increased recently. Such enthusiasm seems well placed. Should the preliminary studies translate through the larger, more powerful studies, the medical community may well have an entirely new platform from which to intervene for health and against disease. Methods: Delineating the pathways involved in the microflora and host interaction is likely to yield further avenues for intervention. Here we examine autonomic function and correlate [...]

2070 8525

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Received: 20 August 2018;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902059

Abstract

Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) from VR scenes has not been adequately investigated. During this study, we used a novel rotating visual scene to study the effects of aging, prior experience with VR, and dementia on the accuracy of encoding categorical [...]

1894 10094

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Received: 31 January 2019;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902058

Abstract

Background: Quality or healthy aging refers to well-being in an older age. In the light of recent changes in the discourse on approaches on positive aging, we aimed to study the way “quality aging” is understood, expressed, and dealt with as a part of contemporary technology assessment (TA), since the nexus between demographic and technological changes has remained a staple topic in TA for at least three decades. Methods: A bottom-up qualitative content analysis was performed to identify the concepts of [...]

2133 12065

Open Access Review

Sleep and Help Seeking Behaviours in Australia: A Narrative Review

Received: 22 March 2019;  Published: 27 June 2019;  doi: 10.21926/obm.neurobiol.1902029

Abstract

Inadequate sleep is a largely under recognised problem in Australia despite researchers consistently highlighting it as a key component of health and wellbeing. Over a third of Australian adults now experience some form of inadequate sleep, which is consistently linked to a range of accompanying physical and mental health concerns. In addition to the health burden on the individual, the associated financial burden incurred by the community is extremely high with inadequate sleep costing over 66.3 billion annually i [...]

1638 12618

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Received: 05 November 2018;  Published: 27 June 2019;  doi: 10.21926/obm.transplant.1902070

Abstract

In recent years, the potential of hematopoietic stem cells, regulatory T-cells, and mesenchymal stem cells have brought about a variety of clinical tolerance trials. Every approach has yielded promising results; however, the riddle of transplant tolerance has not been solved as of yet. The results of the ongoing trials in this field will provide additional information regarding the risks and benefits of these therapy approaches.

1975 11403

Open Access Original Research

Individual Radiosensitivity in Lung Cancer Patients Assessed by G0 and Three Color Fluorescence in Situ Hybridization

Received: 27 July 2018;  Published: 26 June 2019;  doi: 10.21926/obm.genet.1902082

Abstract

Background: It is well known that radiosensitivity varies substantially from individual to individual. This may influence the tumor response and also cause side effects in normal tissues following the radiotherapy treatment for cancers. Therefore, we aimed to analyze the sensitivity of a lung cancer cohort to see whether patients display similar radiosensitivity distribution as compared to healthy individuals. Methods: Blood samples of healthy individuals (n = 244) and a small group of lung cancer patients (n= 38) [...]

2247 11711

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active GLP-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Received: 12 March 2019;  Published: 26 June 2019;  doi: 10.21926/obm.transplant.1902069

Abstract

Background: One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality β cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have been reported to maintain β cell mass and survival. Interestingly, human islets may secrete GLP-1 and they also express the enzyme DPP4 that proteolytically cleaves GLP-1 into an inactive form. The aim of [...]

1709 14992

Open Access Original Research

Experimental Effects of Acute Exercise in Attenuating Concurrent Memory Interference

Received: 13 April 2019;  Published: 25 June 2019;  doi: 10.21926/obm.icm.1902039

Abstract

Acute exercise may enhance episodic memory recall, or the retrospective recall of an event or episode due to exercise-induced neuronal excitability and ensuing long-term potentiation. Of interest to this paper is the potential effects of acute exercise on memory interference, when the interfering stimuli occurs at the same time as the target stimuli. A three-arm, parallel-group randomized controlled intervention was employed. Participants (N=50) were randomized into one of three groups, including 1) Interference + [...]

2029 8628

Open Access Review

The Autotaxin - Lysophosphatidic Acid Axis as a Novel Therapeutic Target for Liver Fibrosis

Received: 27 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.hg.1902024

Abstract

Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of liver function. Lysophosphatidic acid (LPA), a signaling molecule has shown to be involved in various biological processes, including wound healing process. Elevated plasma levels of LPA and its catalyst autotaxin (ATX), [...]

1530 8541

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Received: 11 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.transplant.1902068

Abstract

The ability to routinely and reproducibly obtain purified human islets has facilitated substantial progress in providing a safe and reliable treatment option for adult patients of type 1 diabetes. The availability of human islets for basic research has also significantly improved the understanding of the biology of human islets, and consequently the pathophysiology of diabetes. Presently, about 70 human islet isolation centers are known to exist around the world, in addition to multiple coordinated human islet dist [...]

2316 18116

Open Access Case Report

A De Novo Childhood Case of T-cell Lymphoblastic Leukemia with High Hyperdiploid Karyotype Carrying an Unreported Balanced Translocation t(X;5)(q26;q31.3~32) in A Male Patient

Received: 14 August 2018;  Published: 20 June 2019;  doi: 10.21926/obm.genet.1902081

Abstract

Background: The aggressive T-cell acute lymphoblastic leukemia (T-ALL) is one of the frequently occurring malignancies of the thymocytes. T-ALL is observed in 15% and 25% of all new diagnosed ALL cases in children and adults, respectively. Notably, T-ALL has a 3-fold higher incidence in males than in females. In nearly half of T-ALL cases, structural and/or numerical chromosomal abnormalities are detected, which have an important prognostic significance. A well-known genetic subtype of B-ALL, high hyperdiploidy (He [...]

2203 11069

Open Access Research Article

Preliminary Long-Term Results of Homeopathic Treatment of Atopic Diseases in Adult Patients

Received: 01 November 2018;  Published: 20 June 2019;  doi: 10.21926/obm.icm.1902038

Abstract

Aim: To study the effect of homeopathic treatment on adult patients with atopic diseases visited at the Homeopathic Clinic of Lucca (Italy) and long-term evolution of the disease over approximately an 8-year period. Materials and Methods: Data derive from an observational longitudinal study carried out on 563 atopic adult patients who were consecutively visited from 1998 to 2017; 202 (35.9%) suffered from atopic dermatitis, 204 (36.2%) from allergic rhinitis, and 157 (27.9%) from asthma. Moreover, a long-term study [...]

2322 15512

Open Access Opinion

Doing Brief Work, Slowly: Compassion as Intervention in Behavioral Medicine

Received: 20 March 2019;  Published: 18 June 2019;  doi: 10.21926/obm.icm.1902037

Abstract

Integration of behavioral health consultants and specialists into medical settings has accelerated the development of evidenced-based practices for an array of problems and concerns common to behavioral medicine. Though these treatments have shown to be beneficial for those that engage in protocols, attrition remains high. With an emphasis in directed problem solving and skill building, many brief treatments leave little room for compassion, validation, and understanding. This article explores this trend and advoca [...]

1986 8950

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Received: 09 March 2019;  Published: 18 June 2019;  doi: 10.21926/obm.transplant.1902067

Abstract

Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in donation after circulatory death (DCD), blood collection may delay delivery of preservation solutions resulting in longer warm ischaemic times for the heart and other organs. Banked blood (BB) is a potential alternative [...]

1873 10113

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Abstract

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

1835 10030

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Received: 20 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902056

Abstract

Alzheimer’s Disease is increasingly seen as the major health problem in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The pervasiveness of this view can mean that other perspectives and even the views of those most touched by the challenges of dementia remain unheard. Part of the cultural conversation around dementia is informed by [...]

1672 8567

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Received: 14 February 2019;  Published: 17 June 2019;  doi: 10.21926/obm.transplant.1902066

Abstract

In non-endemic regions of the world, human T-cell lymphotropic virus type-1 (HTLV-1) is an uncommon pathogen in the transplant host, but can be associated with significant morbidity and mortality. Careful assessment for risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timely recognition and management in the transplant host. The use of antiretroviral agents in the management of symptomatic disease due to HTLV-1 remains controversial [...]

1864 9961

Open Access Review

Zinc in Liver Fibrosis

Received: 15 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.hg.1902023

Abstract

Acute and in particular chronic liver disease of viral, alcoholic and non-alcoholic genesis is a large, often unnoticed health hazard around the world. It can lead to cirrhosis and hepatocellular carcinoma (HCC) in the course of decades. Liver fibrosis, conversion of functional parenchyma to connective tissue (scar tissue) as a consequence of chronic liver damage, is a connecting pathogenic process in all chronic liver diseases. Zinc is an essential micronutrient in human health, playing a fundamental role in cellu [...]

1559 9044

Open Access Perspective

Compassion in Preregistration Nurse Education: An Integrated Review

Received: 07 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.icm.1902036

Abstract

The evolving, dynamic and challenging healthcare landscape requires that the art and science of nursing equip preregistration nursing students with the knowledge and skills to positively respond to these changes. Central to these students’ ability to demonstrate competence in the fundamentals of nursing care are core nursing attributes to meaningfully engage and attend to patients’ in delivering compassionate care and meeting their needs. The literature identifies the process of delivering compassionate care as a h [...]

2162 14118

Open Access Case Report

Cancer and the Display of Lymph Nodes Using Potentized Remedies (Derivates of Iodine and Carbo Animalis)

Received: 10 May 2018;  Published: 10 June 2019;  doi: 10.21926/obm.icm.1902035

Abstract

(1) Background: The article provides insight into the mode of the immune system acting hierarchically when administering potentized remedies. Occasionally, this can be best seen in severe cases as available with cancer. (2) Methods: The careful anamnesis and subsequent prescription is based on Jan Scholten’s hierarchic classification of homeopathic mineral remedies. (3) Results: In such cases we find syndrome shifts of symptoms shifting from vital to less vital organs, from inside outside and from up downwards, e [...]

2426 46989

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Received: 18 February 2019;  Published: 10 June 2019;  doi: 10.21926/obm.transplant.1902065

Abstract

Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infections despite their association with increased morbidity and mortality. Various studies have linked respiratory viral infections with acute cellular rejection and chronic allograft dysfunction, and emerging data indicates a [...]

1615 10437

Open Access Review

Managing Acute Severe Necrotising Pancreatitis

Received: 25 February 2019;  Published: 05 June 2019;  doi: 10.21926/obm.hg.1902022

Abstract

Background: Severe necrotising pancreatitis (SNP) is characterised by high mortality, severe complications and bad prognosis despite progress in understanding of aetiology and progression of the disease. Traditionally, necrotic changes were removed by open necrosectomy but the paradigm has shifted towards more conservative management and minimally-invasive surgical procedures. However, there is still no consensus on the best management pathway. Minimally-invasive procedures percutaneous drainage, endoscopic transl [...]

1382 6648

Open Access Opinion

The Curing of Crohn’s Disease

Received: 06 January 2019;  Published: 04 June 2019;  doi: 10.21926/obm.hg.1902021

Abstract

Using the therapeutic intervention points identified by the Hruska Postulate, the probability of curing Crohn’s disease through destroying the anti-MAP template is discussed.

1356 6109

Open Access Case Report

Auriculotherapy for Intractable Hiccups-A Case Report

Received: 22 March 2019;  Published: 04 June 2019;  doi: 10.21926/obm.icm.1902034

Abstract

A 16 year old girl was evaluated for intractable hiccups for 6 six months, with a prior negative clinical and laboratory evaluation, and without any improvement with a variety of folk and medicinal therapies. A single treatment session of auriculotherapy produced a full clinical remission.

2135 11845

Open Access Editorial

The Landscape of Current Meditation Research: An Overview to the Special Issue on 'Health Benefits of Meditation'

Received: 29 May 2019;  Published: 31 May 2019;  doi: 10.21926/obm.icm.1902033

Abstract

The Landscape of Current Meditation Research: An Overview to the Special Issue on “Health Benefits of Meditation”

2207 12110

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Received: 29 January 2019;  Published: 24 May 2019;  doi: 10.21926/obm.geriatr.1902055

Abstract

The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Respect for the autonomy of older persons is highlighted as a cornerstone of care by medical professionals and family members. There remains the challenge, however, of caring for older people who do not have full decision-making cap [...]

3677 40050

Open Access Review

Meditation, Sleep, and Performance

Received: 12 February 2019;  Published: 24 May 2019;  doi: 10.21926/obm.icm.1902031

Abstract

Meditation describes a large variety of traditions that are extremely variable, but all include the conscious focus or awareness of attention. By maintaining their attention, meditators experience both acute and long-term changes in physiology, anatomy, and cognitive performance. The literature shows that the type of performance benefits may depend on the specific type of mental training. During meditation practice there is a documented increase in neuronal coordination and slowing of neuronal firing across many re [...]

2641 36615

Open Access Editorial

Highlights of Complementary and Alternative Medicine in Nervous System Conditions: An Interview with Dr. James David Adams, Jr.

Received: 24 May 2019;  Published: 24 May 2019;  doi: 10.21926/obm.icm.1902032

Abstract

Highlights of Complementary and Alternative Medicine in Nervous System Conditions: An Interview with Dr. James David Adams, Jr.

1308 7284

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Received: 29 March 2019;  Published: 24 May 2019;  doi: 10.21926/obm.transplant.1902064

Abstract

Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for translational research or pre-clinical studies. In this study, we successfully isolated islets from human research pancreata using enriched collagenase products supplemented with BP Protease (DE Collagenase 800 or Collagena [...]

1980 15501

Open Access Review

Airborne Interindividual Transmission of Pneumocystis jirovecii

Received: 17 December 2018;  Published: 22 May 2019;  doi: 10.21926/obm.genet.1902080

Abstract

Pneumocystis pneumonia (PCP) is the most frequent AIDS-defining disease among HIV-infected individuals in developed countries, and also affects immunocompromised non-HIV patients. Experimental studies on rodent models carried out in the early eighties have shown that Pneumocystis spp. can be transmitted via the airborne route. Unfortunately, this mode of acquisition and transmission has long been overlooked by physicians because PCP in immunosuppressed patients was considered to result from reactivation of a latent [...]

2136 11247

Open Access Research Article

NF-κB; the Critical Link between Immune and Metabolic Pathways: Could NF-κB be Used as a Novel Diagnostic and Prognostic Biomarker for Non-Alcoholic Steatohepatitis?

Received: 28 January 2019;  Published: 22 May 2019;  doi: 10.21926/obm.hg.1902020

Abstract

(1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or activators of nuclear factor-κappa B (NF-κB), which is a key transcription factor and plays a pivotal role in the homeostasis and the regulation of inflammatory signaling pathways in the liver. (2) Methods: Our study po [...]

1543 9336

Open Access Original Research

Empirical Examination of Caregiving Processes and Outcomes among Adult Siblings of Individuals with Intellectual and Developmental Disabilities

Received: 25 February 2019;  Published: 20 May 2019;  doi: 10.21926/obm.geriatr.1902054

Abstract

Background: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. Methods: In this study, we examined caregiving processes and outcomes among 322 adult sibling support providers (SSPs) with a range of support roles. Adapting a model of caregiving outcomes, we used structural equation modeling to assess relationships amo [...]

1805 11230

Open Access Review

The Changed Transcriptome of Muscular Dystrophy and Inflammatory Myopathy: Contributions of Non-Coding RNAs to Muscle Damage and Recovery

Received: 28 February 2019;  Published: 16 May 2019;  doi: 10.21926/obm.genet.1902079

Abstract

In order to successfully recover from damage, skeletal muscle tissue requires proper activation of a tightly orchestrated repair program. Non-coding RNAs actively participate in this complex process of demolition and rebuilding. In this review, the contribution of dysregulated non-coding RNA expression to disease-associated pathological changes is explored in hereditary muscular dystrophies and idiopathic inflammatory myopathies. Disturbances in spatiotemporal expression of non-coding RNAs appear to be key factors [...]

2254 10115

Open Access Review

Pneumocystis Species Co-evolution: State-of-the-Art Review

Received: 22 February 2019;  Published: 15 May 2019;  doi: 10.21926/obm.genet.1902078

Abstract

Pneumocystis spp. are a group of fungi that are known for causing opportunistic infections in immunocompromised individuals. It was only at the end of the 20th century that the scientific community challenged the notion of a unique species in the genus Pneumocystis (i.e., Pneumocystis carinii) that drastically changed the understanding of the natural history of pneumocystosis. It is now accepted that the Pneumocystis genus comprises a group of heterogenous fungi having multiple stenoxenic biological entities. These [...]

2206 11362

Open Access Case Report

Diagnosis of Fetal Kabuki Syndrome By Exome Sequencing Following Non-Specific Ultrasound Findings

Received: 11 March 2019;  Published: 15 May 2019;  doi: 10.21926/obm.genet.1902077

Abstract

Background: Fetal exome sequencing is becoming a crucial modality for genetic investigation whenever fetal malformations are documented in the context of normal chromosomal microarray analysis (CMA). When ultrasound findings are non-specific, the robustness of exome sequencing may be the only way to achieve a molecular diagnosis during pregnancy. Case: We describe a case of multiple non-specific fetal findings with the eventual diagnosis of fetal Kabuki Syndrome by exome sequencing. Conclusions: This case stresses [...]

2151 13992

Open Access Review

Organotin Polymers for the Control of Pancreatic Cancer

Received: 31 January 2019;  Published: 14 May 2019;  doi: 10.21926/obm.hg.1902019

Abstract

Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epithelioid carcinoma pancreatic cell line. Synthesis is rapid employing commercially available reactants and the interfacial polymerization that is employed in the commercial synthesis of aramids and polycarbonates.

1348 7731

Open Access Case Report

Changes in SPECT Brain Imaging in Pediatric Patients with Suspected Neuroborreliosis: A Series of 6 Cases

Received: 01 April 2019;  Published: 14 May 2019;  doi: 10.21926/obm.neurobiol.1902028

Abstract

Lyme disease is a spirochetal illness transmitted primarily through the bite of ticks. The disease has a broad spectrum of comorbid conditions including osteoarticular, cardiovascular, and neurological involvement. In addition, clinical variability depends on the age of affected individuals. The Center for Disease Control recognizes the disease as an epidemic and mentions it to be a major morbidity burden in our environment because of the frequent lack of diagnosis and early treatment. Scientific literature mention [...]

1500 9421

Open Access Review

Connections between Early-Life Neuroinflammation, Neural Stem Cells and Progenitors and Origins of Neuropsychiatric Disorders

Received: 13 February 2019;  Published: 13 May 2019;  doi: 10.21926/obm.neurobiol.1902027

Abstract

A number of studies have highlighted the connection between infections during pregnancy in mothers and increased risk for neuropsychiatric disorders later in life leading to the view that maternal immune activation is a significant contributor to psychiatric illnesses. Meta-analyses have revealed associations between the incidence of premature birth and perinatal inflammation with smaller total brain volumes, cognitive, motor and behavioral deficits in childhood and adolescents. In animal studies where inflammati [...]

2034 13269

Open Access Original Research

Liver Transplantation or Resection for Treatment of Hepatocellular Carcinoma in Patients with Well-Compensated Cirrhosis: A Decision Analysis Model

Received: 18 March 2019;  Published: 13 May 2019;  doi: 10.21926/obm.transplant.1902063

Abstract

Background: Hepatocellular carcinoma (HCC) is a lethal tumor, for which liver resection and transplantation are the only potentially curative treatments. No prospective, randomized study has compared survival in patients with compensated cirrhosis after the two operations Methods: Decision analysis modeling is an objective method to quantify risks and benefits. This study aimed to use decision analysis with a Markov model to estimate the impact of liver transplant and surgical resection on survival for patients wit [...]

1389 10214

Open Access Review

Admiral Nurse Case Management: A Model of Caregiver Support for Families Affected by Dementia

Received: 26 February 2019;  Published: 10 May 2019;  doi: 10.21926/obm.geriatr.1902053

Abstract

There has been a strong thrust to identify the needs of people with dementia against a background of person-centred care, however, people with dementia do not exist in isolation; they live within relational contexts with family members. Case management is a model of care that has its origins in supporting patients with a long term disease, however, a very practical approach to case management that can support the care needs of both the person with dementia and the family carers is emerging in the UK. Admiral Nursin [...]

2577 18344

Open Access Review

The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory Relationship

Received: 30 March 2019;  Published: 10 May 2019;  doi: 10.21926/obm.neurobiol.1902026

Abstract

Objective: The objective of this paper was to evaluate the extent to which exercise may influence long-term potentiation (LTP), a key cellular correlate of episodic memory function. Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar. Results: The computerized searches revealed 20 articles meeting the study criteria. Among these 20 evaluated articles, 17 were conducted in an animal model and 3 among humans. All 17 of these studies, with the exce [...]

2670 22363

Open Access Research Article

The Relationship between Caregiver Stress and Behavioural Changes in Dementia

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Abstract

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston Standardized Cognitive Asse [...]

2398 13636

Open Access Editorial

Editorial: “A New Era in Neuro-Oncology”

Received: 05 May 2019;  Published: 08 May 2019;  doi: 10.21926/obm.neurobiol.1902025

1417 7148

Newsletter  

TOP