OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 6 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Open Access Original Research

Views of Conventional Medicine and Integrative Medicine among Informal Dementia Caregivers and Healthcare Professionals in NW England

Garuth Eliot Chalfont, Jane Simpson, Fiona J R Eccles, Christine Milligan
Received: September 06, 2019; Published: January 21, 2020; doi:10.21926/obm.geriatr.2001102

Abstract: The urgent need for innovative approaches to dementia treatment that are acceptable, effective and affordable underlies this research. Growing evidence supports ‘integrative medicine’ as a potential treatment approach aligned with and including conventional medicine. However, success will depend on [...]

Open Access Book Review

Review of: Forgotten: Narratives of Age-Related Dementia and Alzheimer’s Disease in Canada. By Marlene Goldman. McGill-Queen’s Press, 2017

Julia Henderson
Received: November 05, 2019; Published: January 17, 2020; doi:10.21926/obm.geriatr.2001101

Abstract: none

Open Access Highlight

A Unified Model of Age-Related Disease

Michael Fossel
Received: January 14, 2020; Published: January 15, 2020; doi:10.21926/obm.geriatr.2001100

Abstract: none

Open Access Case Report

Implications of Clozapine Complications in Geriatric Patients with Type II Diabetes Mellitus

Charisse Chehovich, Tammie Lee Demler
Received: October 14, 2019; Published: January 10, 2020; doi:10.21926/obm.geriatr.2001099

Abstract: Second-generation antipsychotics, have known metabolic side effects; specifically, clozapine is implicated in worsening or causing hyperglycemia, hypercholesterolemia and weight gain. Recently, there has been an increased interest in the safe use of clozapine in patients with diabetes. In March 2018 [...]

Open Access Original Research

Using Mixed Methods to Explore Older Residents' Physical Activity and Experiences of Community Active Aging Friendliness

Deborah H. John, Patrick Abi Nader, Katherine Gunter
Received: October 29, 2018; Published: January 06, 2020; doi:10.21926/obm.geriatr.2001098

Abstract: Physical inactivity is the fourth leading risk factor for global mortality and as such, it is critical that physical activity guidelines for health consider equitable access to physical activity opportunities for all, including those aged 65 years and older. The purpose of this study was to examine [...]

Open Access Research Article

A Novel Approach to Fall Risk Reduction: Combining Education and Therapeutic Yoga

Em V. Adams, Marieke Van Puymbroeck, Heather S. Torphy, Brian C. Helsel, Karen A. Kemper, Cheryl Dye, Arlene A. Schmid
Received: October 03, 2019; Published: January 03, 2020; doi:10.21926/obm.geriatr.2001097

Abstract: Falls have negative consequences for older adults, but falls can be reduced through interventions that target the reduction of fall risk factors. Cognitive behavioral education programs and therapeutic yoga are two interventions that have independently been used as a means to reduce the risk of fall [...]

Open Access Review

Social Connectedness in Preventing Suicide among Older Adults

Malith Kadirappulli-Hewage, Rasika Jayasekara
Received: August 30, 2019; Published: January 02, 2020; doi:10.21926/obm.geriatr.2001096

Abstract: Social isolation and social disconnectedness have resulted in some older adults ending their lives by suicide; therefore, improving social connectedness has become an integral part of suicide prevention programmes. The purpose of this literature review was to assess the impact of social connectednes [...]

Open Access Review

Design Guidelines to Reduce Extrinsic Fall Risks in the Built Environment

Jeanneane Wood-Nartker, Emily Beuschel, Denise Guerin
Received: August 28, 2019; Published: December 16, 2019; doi:10.21926/obm.geriatr.1904095

Abstract: As people age, environments supporting changing needs can potentially impact their quality of life. Aging often leads to a decrease in the ability of people to interpret sensory cues within their environment. Using Pastalan’s Empathic Model as a framework, a list of guidelines was established to ad [...]

Open Access Original Research

Successful Aging and Positive Psychology: Two Empirically Related Perspectives

María Izal, Roberto Nuevo, Ignacio Montorio
Received: June 19, 2019; Published: December 12, 2019; doi:10.21926/obm.geriatr.1904094

Abstract: We analyze the confluence between two paradigms of health from different theoretical backgrounds: successful (or healthy) aging (SA) and positive psychology (PP). In this cross-sectional study, 169 healthy older adults completed several questionnaires to assess central constructs for successful agi [...]

Open Access Original Research

Women’s Perceptions of the Embodied Experience of Osteoporosis across the Lifecourse

Alyson Holland, Amanda Lorbergs
Received: October 29, 2019; Published: December 12, 2019; doi:10.21926/obm.geriatr.1904093

Abstract: Beliefs about the daily experience of a disease are used to identify risk and motivate participation in prevention. For osteoporosis, a disease that is affected by health behaviours throughout the lifecourse, individual perceptions of the disease can affect health decisions and future disease preval [...]

Open Access Original Research

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

Renate Verkaik, Iris van der Heide, Eugenie van Eerden, Peter Spreeuwenberg, Erik Scherder, Anneke L. Francke
Received: April 02, 2019; Published: December 11, 2019; doi:10.21926/obm.geriatr.1904092

Abstract: Background: Studies of the effectiveness of psychosocial interventions indicate that sensory stimulation is a promising approach to reduce psychological and behavioural disturbances in people with dementia. A relatively new approach is enriched multi-sensory stimulation. Enriched multi-sensory stimu [...]

Open Access Review

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Horst J. Koch
Received: August 06, 2019; Published: December 04, 2019; doi:10.21926/obm.geriatr.1904091

Abstract: The prevalence of Late-life Depression (LLD) is estimated between 10 and 15 % and therefore LLD is a considerable world-wide problem. The psychopathology is not substantially different from that of depressive episodes in young adults, but somatic complaints in combination of end-of-life perspective [...]

Open Access Review

The Association between Bone Turnover Markers and Fracture in People with Diabetes: A Systematic Review and Meta-Analysis

Katrine Hygum, Jakob Starup-Linde, Torben Harsløf, Bente Langdahl
Received: August 29, 2019; Published: December 04, 2019; doi:10.21926/obm.geriatr.1904090

Abstract: Background: The increased fracture risk in persons with diabetes is underestimated by conventional fracture predictors. The aims of this study were to conduct a systematic review and a meta-analysis to compare the levels of bone turnover markers (BTM) in persons with diabetes with and without fractu [...]

Open Access Original Research

Automated Movement Feedback for Recovering Independence in the Sit-to-Stand Movement in an Older Population: A Pilot Randomised Controlled Trial of a Novel System

Siu Fai Ho, Avril Thomson, Tricia Moylan, Julie McGuckin, Andrew Kerr
Received: September 23, 2019; Published: December 02, 2019; doi:10.21926/obm.geriatr.1904089

Abstract: Background The sit-to-stand (StS) movement is a frequently performed task critical to independent living that is both difficult to perform and associated with falls in older populations. Consequently, the recovery of this movement through supervised practice is a priority during the rehabilitation [...]

Open Access Case Report

Physical Illness and Emotional Expression in Late Life

Elizabeth Midlarsky
Received: August 18, 2019; Published: November 25, 2019; doi:10.21926/obm.geriatr.1904088

Abstract: Louise H., Ph.D was referred to me by her long-term primary care physician (PCP) who was certain that his patient was seriously depressed and in need of medication and possibly psychotherapy. My own assessment, in consultation with a neurologist, was that Louise’s problems with coping were primaril [...]

Open Access Research Article

Balance and Fall Rates are Associated with Chronic Pain, and Improve with Yoga

Arlene A. Schmid, Marieke Van Puymbroeck, Christine A. Fruhauf, Laura A. Swink, Jennifer D. Portz
Received: September 29, 2019; Published: November 25, 2019; doi:10.21926/obm.geriatr.1904087

Abstract: Background: Falls are relatively common in older adults and are associated with chronic pain. Chronic pain may even be a predictor of falls in older adults. However, this relationship has not been studied in adults <65 years of age. The purpose of this study was to examine the relationship betwee [...]

Open Access Original Research

Evaluation of the Prevalence of Screening for Dysphagia among Older People Admitted to Medical Services – An International Survey

David Smithard, Signe Westmark, Dorte Melgaard
Received: September 15, 2019; Published: November 15 , 2019; doi:10.21926/obm.geriatr.1904086

Abstract: Background: As the world’s population ages, so the number of old and frail people increases. Respiratory disease is a common reason for hospital admission for older people. Aspiration of saliva, which is probably infected, is the likely etiological agent. The presence of an abnormal swallow has been [...]

Open Access Editorial

Fragility Fractures in the Elderly Osteoporotic Patient and the Efficacy of Fracture Liaison Service Programs

Tarik Wasfie, Avery Jackson III, Cara Marie Brock, Stefanija Galovska, Jennifer Hille
Received: November 07, 2019; Published: November 13, 2019; doi:10.21926/obm.geriatr.1904085

Abstract: None.

Open Access Case Report

Qualitative Evaluation of Interdisciplinary Service Learning Experience to Assess and Manage Fall Risk in Community-Dwelling Older Adults

Susan Kane Patton, Jennifer Vincenzo, Holly B. Bennett, Michelle Gray, Leah Jean Henry, Alishia Ferguson, Ro Dibrezzo, Christopher S. Walter, Maryalice Kelly
Received: August 15, 2019; Published: October 29, 2019; doi:10.21926/obm.geriatr.1904084

Abstract: Aim: This case study reports on the planning and implementation of a fall risk assessment and prevention activity for older adults offered in multiple community settings by health professional faculty and students. Background: In the US, the percentage of adults 65 and older who fell was more than 2 [...]

Open Access Review

Ageing: The Role of Ageism

Sheri R. Levy, MaryBeth Apriceno
Received: June 20, 2019; Published: October 28, 2019; doi:10.21926/obm.geriatr.1904083

Abstract: Worldwide, people are living longer but not necessarily experiencing optimal health since healthy ageing stems from a combination of biological, psychological, and social factors. The growing interdisciplinary literature on ageism from education, medicine, psychology, and social work increasingly h [...]

Open Access Research Article

Using Health-Related Quality of Life (SF-36v2®) to Predict Falls in Community-Dwelling Older Adults

Elena Crooks, Kimberly Cleary
Received: September 14, 2019; Published: October 25, 2019; doi:10.21926/obm.geriatr.1904082

Abstract: Background: Falls are the leading cause of hospitalization and death among older adults; therefore, the ability to predict fall risk among older adults is critical. Several performance-based outcome measures exist to assess fall risk. Psychological factors are also associated with fall risk yet can [...]

Open Access Concept Paper

Admiral Nursing in Primary Care: Peri and Post-Diagnostic Support for Families Affected by Dementia within the UK Primary Care Network Model

Zena Aldridge, Karen Harrison Dening
Received: September 19, 2019; Published: October 18, 2019; doi:10.21926/obm.geriatr.1904081

Abstract: The UK population is ageing. In 2017 approximately 18% of the UK population were aged 65 years or over and projected to grow to almost 21% by 2027 according to the Office of National Statistics (ONS) (2018a). Increased age is the greatest risk factor for developing dementia (Van de Flier & Sche [...]

Open Access Original Research

Naming and Framing the Behavioural and Psychological Symptoms of Dementia (BPSD) Paradigm: Professional Stakeholder Perspectives

Emma Wolverson, Heather Birtles, Esme Moniz-Cook, Ian James, Dawn Brooker, Frances Duffy
Received: September 08, 2019; Published: October 11, 2019; doi:10.21926/obm.geriatr.1904080

Abstract: Background Behavioural and Psychological Symptoms of Dementia and Challenging Behaviour in dementia care are just two of a variety of terms for a complex paradigm that covers the most distressing and costly aspects of the condition. The terminology used to describe these aspects can influence what [...]

Open Access Perspective

Behavioral versus Biological Definitions of Dementia Symptoms: Recognizing that Worthwhile Interventions already Exist

Robert J. Brent
Received: July 31, 2019; Published: October 10, 2019; doi:10.21926/obm.geriatr.1904079

Abstract: Background: The 2018 Alzheimer’s Disease Facts and Figures special report includes two new guidelines for measuring dementia symptoms. The first requires that a biomarker (biological factor) be added to a doctor’s clinical judgment of the cause of symptoms when determining whether dementia is presen [...]

Open Access Research Article

GAPcare: The Geriatric Acute and Post-Acute Fall Prevention Intervention for Emergency Department Patients – A Qualitative Evaluation

Elizabeth M. Goldberg, Cameron J. Gettel, Kelsey Hayes, Renee R. Shield, Kate M. Guthrie
Received: August 21, 2019; Published: October 10, 2019; doi:10.21926/obm.geriatr.1904078

Abstract: Three million US emergency department (ED) visits occur for falls each year. The mortality of falls is increasing and only one fourth of older adults report their fall to their primary care provider, suggesting that valuable preventative opportunities are missed. A fall prevention intervention initi [...]

13th Clinical Trials on Alzheimer's Disease (CTAD)

November 4-7, 2020, Boston, USA

The development of the next generation of Alzheimer’s disease treatments is among the most important health needs worldwide, but presents huge challenges. The goal of the meeting is to bring together today’s worldwide leaders in the treatment of Alzheimer’s disease to discuss new results, candidate therapeutics, and methodological issues important to the development of the next generation of Alzheimer’s disease treatments.

Clinical trial teams from worldwide centers will report on their efforts to identify new biomarkers of disease as well as more sensitive clinical assessment tools to identify those at risk for AD, to predict progression, and assess the effectiveness of new treatments.

For more details, please visit: https://www.ctad-alzheimer.com/ctad-2020

Alzheimer's Association International Conference®

July 26-30, 2020, Amsterdam, Netherlands

AAIC 2020 will bring together international investigators, clinicians and care researchers to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

For more details, please visit: https://www.alz.org/aaic/overview.asp

Integrative Regen Group

February 29- March 2, 2020, Arizona Biltmore Resort, USA

Who: Providers of all disciplines who are passionate about or interested in regenerative medicine are encouraged to attend this event. The agenda will be packed full of actionable topics that most attendees will be able to put into effect immediately to continue to provide their patients with the most cutting-edge therapies.

What: Integrative Regen Group’s second conference will be bringing together experts in all areas of regenerative medicine, from stem cells to photobiomodulation, peptides to hormones, and everything in between. It is our goal that every person in attendance increase their knowledge base substantially.

For more details, please visit: https://www.intregengroup.com/

The 2nd Longevity Therapeutics

January 28-30, 2020, San Francisco CA, USA

With rapid advances in the understanding of the underlying biology and mechanisms of aging, ground-breaking research and technology are coming together to target aging pathways, in a way to prevent, reverse or delay the onset of age-related conditions, and consequently improve heathspan.

The 2nd Longevity Therapeutics 2020 Summit will once again bring together 80+ leading experts in aging-related research, including biotechs, pharma, academics and investors, who are committed to serving worldwide population with innovative drugs to prevent, delay and treat age-related conditions.

For more details, please visit: https://longevity-therapeutics.com/

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.



by Michael Fossel

OBM Geriatrics 2020

Published: 15 January 2020

Highlight from: A unified model of dementias and age‐related neurodegeneration.

Michael Fossel.

Alzheimer’s & Dementia.

doi: 10.1002/alz.12012.

Highly Accessed Articles

Case Report

by Garuth Chalfont et al.

OBM Geriatrics 2020

Published: 07 August 2019


by Robert Conder et al.

OBM Geriatrics 2020

Published: 20 March 2019


by Michael Fossel

OBM Geriatrics 2020

Published: 15 February 2019

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