OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Indexing: DOAJ-Directory of Open Access Journals.

Archiving: full-text archived in CLOCKSS.

Rapid publication: manuscripts are undertaken in 6 days from acceptance to publication (median values for papers published in this journal in the first half of 2019, 1-2 days of FREE language polishing time is also included in this period).

Open Access Original Research

Bone Mineral Density in Male Hospital Physicians over the Age of 65 Years

Noa Sylvetsky, Chen Futeran Shahar, Meir Frankel, Gabriel Munter
Received: April 01, 2020; Published: July 02, 2020; doi:10.21926/obm.geriatr.2003126

Abstract: Hospitalists are at risk for vitamin D deficiency during their active years due to indoor working conditions and insufficient sunlight exposure. The impairment of bone mineral density (BMD) in this group has not been studied. A total of 50 male hospitalists aged ≥ 65 years were enrolled. Their BMD w [...]

Open Access Original Research

The Effect of Live Bedside Music on Pain in Elderly Surgical Patients. A Unique Collaboration

Hanneke van der Wal- Huisman, Henk Groen, Erik Heineman, Barbara L. van Leeuwen
Received: April 08, 2020; Published: July 01, 2020; doi:10.21926/obm.geriatr.2003125

Abstract: Postoperative pain has a negative influence on physical and mental recovery and may result in a variety of postoperative complications. Listening to recorded music has been revealed to reduce pain, but in addition to that, live bedside music further offers the possibility to interact with the patien [...]

Open Access Original Research

On the Face of It: Social Heuristics Are Mediated by Age and Sex, But Not by Faciometrics

Julia M. Robertson, Barbara E. Kingsley
Received: February 16, 2020; Published: June 23, 2020; doi:10.21926/obm.geriatr.2002124

Abstract: The ability to situate individuals within social categories provides an important social function, allowing people to navigate problems of survival and reproduction within highly complex social structures. This categorization of people with apparently shared characteristics is facilitated by various [...]

Open Access Review

Bone Health in the Elderly with Type 2 Diabetes Mellitus–A Systematic Review

Zheer Al-Mashhadi, Rikke Viggers, Rasmus Fuglsang-Nielsen, Bente Langdahl, Peter Vestergaard, Søren Gregersen, Jakob Starup-Linde
Received: April 02, 2020; Published: June 18, 2020; doi:10.21926/obm.geriatr.2002123

Abstract: Type 2 diabetes mellitus (T2DM) and osteoporosis are two major public health concerns worldwide, contributing to morbidity and mortality in the elderly. Aging is one of the most significant risk factors for low bone mass, bone fragility, and fractures. Among the several comorbidities that affect the [...]

Open Access Research Article

Post-Mortem Comparison of the Incidence and the Distribution of Cerebrovascular Lesions Using Additional 7.0-Tesla Magnetic Resonance Imaging in Cognitive Normal Young, Middle-Aged, and Elderly Persons

Jacques De Reuck, Florent Auger, Nicolas Durieux, Claude-Alain Maurage, Vincent Deramecourt, Charlotte Cordonnier, Florence Pasquier, Didier Leys, Regis Bordet
Received: April 06, 2020; Published: June 04, 2020; doi:10.21926/obm.geriatr.2002122

Abstract: Regional brain atrophy and an escalation in vascular risk are associated to increasing age in normal cognitive healthy persons. The present post-mortem study compares the incidence of cerebrovascular lesions between young-aged, middle-aged, and elderly cognitive normal persons with additional 7.0-te [...]

Open Access Review

Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action

Nikita Francis
Received: March 15, 2020; Published: June 01, 2020; doi:10.21926/obm.geriatr.2002121

Abstract: Despite continuous efforts to combat neurodegenerative diseases, researchers have been unable to find an intervention that reverses degeneration and/or improves cognition in dementia or healthy aging. Therefore, it is considerably important to identify lifestyle factors that could potentially aid in [...]

Open Access Research Article

Association between Very Low Dietary Protein Intake and Subsequent Falls in Community-Dwelling Older Adults in the United States

Marika Haritos Paul, Mary Beth Arensberg, Judy R. Simon, Satya S. Jonnalagadda, Suzette L. Pereira, Jamie S. Partridge, Joseph A. Rosenthal
Received: April 10, 2020; Published: May 22, 2020; doi:10.21926/obm.geriatr.2002120

Abstract: Poor nutrition is linked to frailty and both poor nutrition and frailty are recognized risk factors for falls. This study examined the association between dietary protein intake and subsequent reported falls in community-dwelling older Americans with a history of falls. Other nutritional, functional [...]

Open Access Research Article

Adoption of a Patient-Tailored Fall Prevention Program in Academic Health Systems: A Qualitative Study of Barriers and Facilitators

Eileen J. Carter, Srijesa Khasnabish, Jason S. Adelman, Michael Bogaisky, Mary Ellen Lindros, Lois Alfieri, Maureen Scanlan, Ann Hurley, Megan Duckworth, Alexandra Shelley, Kenrick Cato, Shao P Yu, Dianne L Carroll, Emily Jackson, Stuart Lipsitz, David W Bates, Patricia C. Dykes
Received: March 23, 2020; Published: May 18, 2020; doi:10.21926/obm.geriatr.2002119

Abstract: Falls represent a persistent and costly patient safety issue. Fall TIPS (Tailored Interventions for Patient Safety) is a patient-centered and clinical decision-supported, fall prevention program that has led to fewer falls and related injuries among hospitalized patients. We aimed to identify domina [...]

Open Access Research Article

Towards Positive Aging: Links between Forgiveness and Health

Noah J. Webster, Kristine J. Ajrouch, Toni C. Antonucci
Received: December 05, 2018; Published: May 12, 2020; doi:10.21926/obm.geriatr.2002118

Abstract: Forgiveness may serve as an essential positive resource to help individuals cope emotionally with stressful events, ultimately influencing health. Examination of how individuals forgive within the context of close relationships can provide useful information about positive aging. In this study, we e [...]

Open Access Review

Glial Alterations in Aging and Alzheimer’s Disease: A Novel Basis to Understand, Prevent and Treat the Degenerative Process

Adolfo Toledano-Díaz, Ma Isabel Álvarez, Adolfo Toledano
Received: December 18, 2019; Published: May 09, 2020; doi:10.21926/obm.geriatr.2002117

Abstract: Neurons, from the time of their birth until their death, are always accompanied by neuroglial cells, maintaining very close morphological and functional relationships among themselves. Classically three main neuroglial families have been considered within the central nervous system (CNS): astroglia, [...]

Open Access Review

New Horizons in Alzheimer Research from Amyloid and Beyond

Jeffrey T. Apter, Kaylee M. White
Received: December 01, 2019; Published: April 29, 2020; doi:10.21926/obm.geriatr.2002116

Abstract: The Amyloid and Tau Hypothesis of Alzheimer’s disease once thought to be the key have shown marginal results but are bolstered by the recent revival of the Aducanumab study and some positive data on some anti-Tau drugs. It still behoves us to look at other mechanisms which include whole blood transf [...]

Open Access Case Report

Intestinal Necrosis Due to Digoxin Intoxication

Line L. Olesen
Received: February 01, 2020; Published: April 21, 2020; doi:10.21926/obm.geriatr.2002115

Abstract: The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardize [...]

Open Access Original Research

Using a Rocking Chair in the Care of People with Dementia: A Single-Case Research Study

Annelie K Gusdal, Christine Gustafsson
Received: November 09, 2019; Published: April 07, 2020; doi:10.21926/obm.geriatr.2002114

Abstract: The people with dementia experience a progressive loss of cognition, while more than 90% of them develop behavioral and psychological symptoms of dementia (BPSD). BPSD may result in physical injuries and psychological distress among people with dementia and their family/caregivers. First-line care s [...]

Open Access Review

Management of Older People With Diabetes - A Focus On Mental Functions

Ahmed H Abdelhafiz
Received: March 05, 2020; Published: April 01, 2020; doi:10.21926/obm.geriatr.2002113

Abstract: The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have b [...]

Open Access Editorial

Geriatric Cardiac Diseases

Giuseppe Cocco
Received: March 20, 2020; Published: April 01, 2020; doi:10.21926/obm.geriatr.2002112

Open Access Review

Known–Unknowns in Geriatric Cardiology

Giuseppe Cocco, Philipp Amiet
Received: February 05, 2020; Published: March 19, 2020; doi:10.21926/obm.geriatr.2001111

Abstract: The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly pa­tients dealing with the prevention of arte [...]

Open Access Review

Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways

Joseph S. D'Arrigo
Received: December 26, 2019; Published: February 28, 2020; doi:10.21926/obm.geriatr.2001110

Abstract: Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. [...]

Open Access Review

Dysphagia and Oral Health in Older People

Sima Farpour, David Smithard, Hamid Reza Farpour
Received: November 14, 2019; Published: February 20, 2020; doi:10.21926/obm.geriatr.2001109

Abstract: Dysphagia is a term that is used for the difficulty in moving liquid/food from mouth to the stomach. Dysphagia is very common in elders, which makes them susceptible to malnutrition, infection, institutionalization, and death. Consequently, it is categorized as a geriatric syndrome. Therefore, multi [...]

Open Access Original Research

Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial

Akemi Hirano, Yusuke Suzuki, Hiroyuki Umegaki, Toshio Hayashi, Koichiro Ina, Joji Onishi, Jun Hasegawa, Masafumi Kuzuya
Received: October 13, 2019; Published: February 19, 2020; doi:10.21926/obm.geriatr.2001108

Abstract: The incidence of vascular diseases among caregivers of dementia patients is high, and one potential cause is the exacerbation of blood coagulability due to mental strain from caregiving. This study aimed to examine the effects of aerobic exercise on blood coagulability, from the perspective of impro [...]

Open Access Short Review

Alzheimer's Disease: Parsing the Pathways Leading to the Disease Based on the Spirochete/Biofilm Hypothesis

Herbert B. Allen
Received: December 31, 2019; Published: February 19, 2020; doi:10.21926/obm.geriatr.2001107

Abstract: A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. Th [...]

Open Access Review

Problems Associated with the Measurement of Neuropsychiatric Symptoms of Dementia

Natalie G. Regier
Received: December 04, 2019; Published: February 17, 2020; doi:10.21926/obm.geriatr.2001106

Abstract: Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfor [...]

Open Access Review

Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease

Marcel Ruiz-Mejias, Patricia Castano-Prat, Tony Donegan, Maria V. Sanchez-Vives
Received: December 31, 2019; Published: February 14, 2020; doi:10.21926/obm.geriatr.2001105

Abstract: Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) eme [...]

Open Access Review

Behaviors of Persons with Dementia: A Review and New Perspective for Future Research

Morgan J. Minyo, Katherine S. Judge
Received: July 30, 2019; Published: February 07, 2020; doi:10.21926/obm.geriatr.2001104

Abstract: Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review cons [...]

Open Access Perspective

Target Tau, not Amyloid, to Prevent and Treat Alzheimer’s Disease

Margaret M Esiri
Received: November 17, 2019; Published: February 04, 2020; doi:10.21926/obm.geriatr.2001103

Abstract: In this article I wish to put the case for a change of emphasis in the approach to finding a prevention/treatment for Alzheimer’s disease from a focus on beta amyloid to one on tau. In particular, I make the case for aiming to prevent the spread of abnormal tau from the medial temporal lobe to wides [...]

Open Access Original Research

Views of Conventional Medicine and Integrative Medicine among Informal Dementia Caregivers and Healthcare Professionals in NW England

Garuth Eliot Chalfont, Jane Simpson, Fiona J R Eccles, Christine Milligan
Received: September 06, 2019; Published: January 21, 2020; doi:10.21926/obm.geriatr.2001102

Abstract: The urgent need for innovative approaches to dementia treatment that are acceptable, effective and affordable underlies this research. Growing evidence supports ‘integrative medicine’ as a potential treatment approach aligned with and including conventional medicine. However, success will depend on [...]

13th Clinical Trials on Alzheimer's Disease (CTAD)

November 4-7, 2020, Boston, USA

The development of the next generation of Alzheimer’s disease treatments is among the most important health needs worldwide, but presents huge challenges. The goal of the meeting is to bring together today’s worldwide leaders in the treatment of Alzheimer’s disease to discuss new results, candidate therapeutics, and methodological issues important to the development of the next generation of Alzheimer’s disease treatments.

Clinical trial teams from worldwide centers will report on their efforts to identify new biomarkers of disease as well as more sensitive clinical assessment tools to identify those at risk for AD, to predict progression, and assess the effectiveness of new treatments.

For more details, please visit: https://www.ctad-alzheimer.com/ctad-2020

Alzheimer's Association International Conference®

July 26-30, 2020, Amsterdam, Netherlands

AAIC 2020 will bring together international investigators, clinicians and care researchers to discuss the latest studies, theories and discoveries that will help bring the world closer to breakthroughs in dementia science.

For more details, please visit: https://www.alz.org/aaic/overview.asp

Integrative Regen Group

February 29- March 2, 2020, Arizona Biltmore Resort, USA

Who: Providers of all disciplines who are passionate about or interested in regenerative medicine are encouraged to attend this event. The agenda will be packed full of actionable topics that most attendees will be able to put into effect immediately to continue to provide their patients with the most cutting-edge therapies.

What: Integrative Regen Group’s second conference will be bringing together experts in all areas of regenerative medicine, from stem cells to photobiomodulation, peptides to hormones, and everything in between. It is our goal that every person in attendance increase their knowledge base substantially.

For more details, please visit: https://www.intregengroup.com/

The 2nd Longevity Therapeutics

January 28-30, 2020, San Francisco CA, USA

With rapid advances in the understanding of the underlying biology and mechanisms of aging, ground-breaking research and technology are coming together to target aging pathways, in a way to prevent, reverse or delay the onset of age-related conditions, and consequently improve heathspan.

The 2nd Longevity Therapeutics 2020 Summit will once again bring together 80+ leading experts in aging-related research, including biotechs, pharma, academics and investors, who are committed to serving worldwide population with innovative drugs to prevent, delay and treat age-related conditions.

For more details, please visit: https://longevity-therapeutics.com/

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.



by Michael Fossel

OBM Geriatrics 2020

Published: 15 January 2020

Highlight from: A unified model of dementias and age‐related neurodegeneration.

Michael Fossel.

Alzheimer’s & Dementia.

doi: 10.1002/alz.12012.

Highly Accessed Articles

Case Report

by Garuth Chalfont et al.

OBM Geriatrics 2020

Published: 07 August 2019


by Robert Conder et al.

OBM Geriatrics 2020

Published: 20 March 2019


by Michael Fossel

OBM Geriatrics 2020

Published: 15 February 2019

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