OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Free Publication in 2019

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Mario D. Garrett
Received: June 12, 2019; Published: July 16, 2019; doi:10.21926/obm.geriatr.1903063

Abstract: Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a centur [...]

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Tracy Harwood, John Maltby, Elizabeta B. Mukaetova-Ladinska
Received: March 28, 2019; Published: July 15, 2019; doi:10.21926/obm.geriatr.1903062

Abstract: Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia bene [...]

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Yoko Moriyama, Timothy Bolt, Marilyn Luptak, Nanako Tamiya
Received: February 19, 2019; Published: July 09, 2019; doi:10.21926/obm.geriatr.1903061

Abstract: Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on shor [...]

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Pavel Kalvach, Martin Vogner
Received: March 30, 2019; Published: July 08, 2019; doi:10.21926/obm.geriatr.1903060

Abstract: Our understanding of the mental deterioration associated with old-age have undergone a number of changes over the past two centuries and have spurred major scientific debates. In the 19th century, this disorder was still considered to be an inevitable feature of aging. The dawn of the 20th century o [...]

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Omid Ranjbar Pouya, Ahmad Byagowi, Debbie M. Kelly, Zahra Moussavi
Received: August 20, 2018; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902059

Abstract: Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) [...]

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Niklas Gudowsky, Ulrike Bechtold, Leo Capari, Mahshid Sotoudeh
Received: January 31, 2019; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902058

Abstract: (1) Background: In the light of recent changes in the discourse on positive ageing approaches, we take a closer look at the way “quality ageing” is understood, expressed and dealt with in technology assessment (TA) that investigates desirable frameworks and futures for an ageing society from a citiz [...]

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Joseph S. D'Arrigo
Received: December 27, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902057

Abstract: Much evidence has been reported which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorpor [...]

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Michael Chapman, Jennifer Philip, Paul Komesaroff
Received: December 20, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902056

Abstract: Alzheimer’s Disease is increasingly seen as the major health in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The perva [...]

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Terence Seedsman
Received: January 29, 2019; Published: May 24, 2019; doi:10.21926/obm.geriatr.1902055

Abstract: The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Research inv [...]

Open Access Original Research

Empirical Examination of Caregiving Processes and Outcomes among Adult Siblings of Individuals with Intellectual and Developmental Disabilities

Mamta Saxena, Anne F. Farrell, Kari Adamsons
Received: February 25, 2019; Published: May 20, 2019; doi:10.21926/obm.geriatr.1902054

Abstract: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. In this study, we examined caregiving processes [...]

Open Access Review

Admiral Nurse Case Management: A Model of Caregiver Support for Families Affected by Dementia

Karen Harrison Dening, Zena Aldridge
Received: February 26, 2019; Published: May 10, 2019; doi:10.21926/obm.geriatr.1902053

Abstract: People with dementia do not exist in isolation and whilst there has been a strong thrust to identify the needs of people with dementia against a background of person centred care, they live within relational contexts with family members. Case management is a model of care that can support the care [...]

Open Access Research Article

The Relationship between Caregiver Stress and Behavioural Changes in Dementia

Lindy A. Kilik, Robert W. Hopkins
Received: March 01, 2019; Published: May 09, 2019; doi:10.21926/obm.geriatr.1902052

Abstract: Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston [...]

Open Access Concept Paper

Biological Age versus Chronological Age in the Prevention of Age Associated Diseases

Gian Andrea Rollandi, Aldo Chiesa, Nicoletta Sacchi, Mauro Castagnetta, Matteo Puntoni, Adriana Amaro, Barbara Banelli, Ulrich Pfeffer
Received: January 31, 2019; Published: May 05, 2019; doi:10.21926/obm.geriatr.1902051

Abstract: Aging is associated with an increasing incidence of major diseases among which cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome and quality of life and are commonly appl [...]

Open Access Project Report

An Evaluation of a Community-Based Psychoeducation Program for Successful Ageing

Claire L. Thompson , Daniela Calafiore, Julijana Chochovski, Steven Trawley, Kathryn von Treuer
Received: October 29, 2018; Published: April 26, 2019; doi:10.21926/obm.geriatr.1902050

Abstract: (1) Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to [...]

Open Access Original Research

Moderators of Treatment Outcomes from Family Caregiver Skills Training: Secondary Analysis of a Randomized Controlled Trial

Michael P. Cary, Jr., Valerie A. Smith, Megan Shepherd-Banigan, Jennifer H. Lindquist, Jennifer G. Chapman, Susan N. Hastings, Courtney H. Van Houtven
Received: February 22, 2019; Published: April 18, 2019; doi:10.21926/obm.geriatr.1902049

Abstract: Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and care [...]

Open Access Case Report

Daily Observations of Preserved Cognition and Quality of Life after Multiple Therapies for Postmortem-Verified Severe Alzheimer’s

Keith A. Wollen, John W. Hoyt
Received: February 15, 2019; Published: April 18, 2019; doi:10.21926/obm.geriatr.1902048

Abstract: Abstract Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This stud [...]

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Joseph V. Pergolizzi, Jr., Jo Ann LeQuang
Received: November 13, 2018; Published: April 17, 2019; doi:10.21926/obm.geriatr.1902047

Abstract: As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug dispos [...]

Open Access Review

Engagement and Utilization of Advance Care Planning and Hospice in Different Older Asian American Populations

Kristy Lui, Darlene Yee-Melichar, Emiko Takagi
Received: October 31, 2018; Published: April 08, 2019; doi:10.21926/obm.geriatr.1902046

Abstract: This research review intended to examine the patterns of engagement in advance care planning (ACP) and utilization of end-of-life (EoL) care treatment services including, but not limited to hospice care, in distinct older Asian American ethnic groups. The research analysis suggested evidence that st [...]

Open Access Comment

hTERT Promoter Regulation by Differentiation Mechanisms vs Telomerase Activity in Somatic, Embryonic, and Cancerous Cells

Steve Liebich
Received: February 02, 2019; Published: April 04, 2019; doi:10.21926/obm.geriatr.1902045

Abstract: Telomere shortening in the somatic cells is one of the most well-documented factors of cellular ageing. Telomeres are composed of tandem hexanucleotide repeats that protect cells from unwanted recombination mechanisms, secure the ends of chromosomes and their stability, and are responsible for limit [...]

Open Access Research Article

Examining the Effectiveness of Two Types of Forgiveness Intervention to Enhance Well-Being in Adults from Young to Older Adulthood

Olga Zichnali, Despina Moraitou, Christos Pezirkianidis, Anastasios Stalikas
Received: October 30, 2018; Published: April 03, 2019; doi:10.21926/obm.geriatr.1902044

Abstract: Background: The present study examined the efficacy of two self-guided interventions, which aimed at enhancing adults’ wellbeing through the cultivation of forgiveness skills. Methods: A total of 11 men and 31 women aged 34-80 years were involved (M = 56.57, S.D. = 13.44). The participants were asked [...]

Open Access Original Research

The Positive Power of Perception in Late Life: A Study on Subjective Aging and Health among Ethnic Minorities

Ana Jessica Alfaro, Soledad Argüelles-Borge, Ashley M. Stripling, Paula M. Brochu
Received: September 17, 2018; Published: March 29, 2019; doi:10.21926/obm.geriatr.1901043

Abstract: The main objective of this empirical study was to investigate subjective aging in late life among ethnic minorities in the United States. Specifically, this study examined age identity, or how old one feels, in relation to psychological well-being (PWB) and functional health. The aims were trifold: [...]

Open Access Editorial

Depression and Aging: Role of Social Support

Ray Marks
Received: March 25, 2019; Published: March 28, 2019; doi:10.21926/obm.geriatr.1901042

Abstract: Depression and Aging: Role of Social Support

Open Access Review

Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and Hostility

Lei Zhang, Xian-Zhang Hu, Xiaoxia Li, Jacob Dohl, Tianzheng Yu, Robert J. Ursano
Received: December 28, 2018; Published: March 21, 2019; doi:10.21926/obm.geriatr.1901041

Abstract: Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to [...]

Open Access Review

Does Dementia Increase the Risk of Dental Decay?

Robert J Emanuel
Received: January 09, 2019; Published: March 21, 2019; doi:10.21926/obm.geriatr.1901040

Abstract: The amount of patients who suffer with dementia is set to rise with an ageing population living longer. As well as living longer, patients will be retaining their natural teeth longer and will be less reliant on dentures. From both the current evidence available in the literature, and anecdotally [...]

Open Access Perspective

Behavioural and Complementary Interventions for Healthy Neurocognitive Aging

Robert L. Conder, Jr., Christopher Friesen, Alanna A. Conder
Received: November 30, 2018; Published: March 20, 2019; doi:10.21926/obm.geriatr.1901039

Abstract: Background: While the percent of persons 65 and older is expected to increase to 17% of the world’s population by 2050, this increase in longevity does not necessarily suggest a parallel increase in health status. While aging is an inevitable aspect of living, there are factors which can accelerate [...]

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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