OBM Geriatrics

(ISSN 2638-1311)

OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes. There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Free Publication in 2019

Open Access Review

Facilitation of Social Support through Negative Allosteric Modulation of α5-Associated GABAA Receptors: A Novel Mechanism for the Treatment of Depression, Agitation, and Aggression in the Elderly

Jeffrey M. Witkin, Lalit K. Golani, Rok Cerne, Md. Toufiqur Rahman, Guanguan Li, Michael M. Poe, James M. Cook, Jodi L. Smith
Received: May 05, 2019; Published: August 26, 2019; doi:10.21926/obm.geriatr.1903073

Abstract: Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Recent and accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modul [...]

Open Access Original Research

Wisdom of the Elders: Narratives Enhancing Trainees’ Attitudes Towards Aging

James S. Powers, Destiny O. Birdsong, Kemberlee R. Bonnet, Neena R. Kapoor, Jamaria J. Southward, Ifeoma Nwankwo, David G. Schlundt
Received: April 25, 2019; Published: August 26, 2019; doi:10.21926/obm.geriatr.1903072

Abstract: Background: Narratives encompass written reflection experiences and hold the potential to display valuable insights into trainees’ thinking. We analyzed narratives from graduate students trained in aging themes, who then interviewed older hospitalized adults (senior partners) about their life exper [...]

Open Access Original Research

Atrial Fibrillation, Anticoagulation, and Major Bleeding Episodes in Geriatric Patients at the Risk of Falling

Lennaert Zwart, Tjeerd Germans, Suat Simsek, Jaap Ruiter, René Jansen
Received: May 22, 2019; Published: August 26, 2019; doi:10.21926/obm.geriatr.1903071

Abstract: Background: Geriatric patients are at risk for atrial fibrillation (AF), stroke, and the risk of anticoagulation (OAC) related bleeding is presumed to be higher. Detailed knowledge about the prevalence of AF and bleeding pattern in this population is scarce. This study sought to assess the prevalenc [...]

Open Access Review

Shedding Light on Manic Syndromes and Dementia

Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Claudio Lucetti, Angelo Nuti, Mario Di Fiorino
Received: March 27, 2019; Published: August 16, 2019; doi:10.21926/obm.geriatr.1903070

Abstract: Background. Mania in older adults is associated with a high rate of medical and neurological disease. Objective. The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods. Medline and Google Scholar searches were conducted for relevant artic [...]

Open Access Original Research

Intranasal Insulin in Alzheimer’s Disease: A Pragmatic Account

Sara Schatz, Melvin Gonzalez Rivera
Received: March 15, 2019; Published: August 13, 2019; doi:10.21926/obm.geriatr.1903069

Abstract: Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and ear [...]

Open Access Review

The Value Given and Presupposed in Person-Centred Dementia Care

Stephen Ames
Received: April 08, 2019; Published: August 13, 2019; doi:10.21926/obm.geriatr.1903068

Abstract: Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the stand [...]

Open Access Original Research

Differential Effects of Social Network on Health in Later Life and the Moderating Role of Depression

Shira Peleg, Howard Litwin
Received: March 23, 2019; Published: August 12, 2019; doi:10.21926/obm.geriatr.1903067

Abstract: Background: We studied the differential effects of social network characteristics on limitations with activities (LWA) and quality of life (QOL) among older adults, and the moderating role of depression. Methods: Data from two consecutive waves of the Survey of Health, Aging and Retirement in Europe [...]

Open Access Case Report

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Garuth Chalfont, Jane Simpson, Sarah Davies, David Morris, Ruth Wilde, Leigh Willoughby, Christine Milligan
Received: April 08, 2019; Published: August 07, 2019; doi:10.21926/obm.geriatr.1903066

Abstract: The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a ‘personalised medicine’ approach challenges this view. This paper reviews the current evidence for dementia prevention utili [...]

Open Access Review

A Model for Understanding Hispanic/Latino Family Caregiving for Older Adults

Hsueh-Fen S. Kao, Maria A. Amaya
Received: May 19, 2019; Published: August 07, 2019; doi:10.21926/obm.geriatr.1903065

Abstract: Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families [...]

Open Access Review

Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5

Ian Macreadie, Sudip Dhakal
Received: May 05, 2019; Published: July 17, 2019; doi:10.21926/obm.geriatr.1903064

Abstract: The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided many insights into molecular and cellular biology, as well as insights into many human diseases. In this paper we present some insights on how yeast studies are contributing to knowledge about the role of oxidative damage to cel [...]

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Mario D. Garrett
Received: June 12, 2019; Published: July 16, 2019; doi:10.21926/obm.geriatr.1903063

Abstract: Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a centur [...]

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Tracy Harwood, John Maltby, Elizabeta B. Mukaetova-Ladinska
Received: March 28, 2019; Published: July 15, 2019; doi:10.21926/obm.geriatr.1903062

Abstract: Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia bene [...]

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Yoko Moriyama, Timothy Bolt, Marilyn Luptak, Nanako Tamiya
Received: February 19, 2019; Published: July 09, 2019; doi:10.21926/obm.geriatr.1903061

Abstract: Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on shor [...]

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Pavel Kalvach, Martin Vogner
Received: March 30, 2019; Published: July 08, 2019; doi:10.21926/obm.geriatr.1903060

Abstract: Our understanding of the mental deterioration associated with old-age have undergone a number of changes over the past two centuries and have spurred major scientific debates. In the 19th century, this disorder was still considered to be an inevitable feature of aging. The dawn of the 20th century o [...]

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Omid Ranjbar Pouya, Ahmad Byagowi, Debbie M. Kelly, Zahra Moussavi
Received: August 20, 2018; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902059

Abstract: Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) [...]

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Niklas Gudowsky, Ulrike Bechtold, Leo Capari, Mahshid Sotoudeh
Received: January 31, 2019; Published: June 27, 2019; doi:10.21926/obm.geriatr.1902058

Abstract: (1) Background: In the light of recent changes in the discourse on positive ageing approaches, we take a closer look at the way “quality ageing” is understood, expressed and dealt with in technology assessment (TA) that investigates desirable frameworks and futures for an ageing society from a citiz [...]

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Joseph S. D'Arrigo
Received: December 27, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902057

Abstract: Much evidence has been reported which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorpor [...]

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Michael Chapman, Jennifer Philip, Paul Komesaroff
Received: December 20, 2018; Published: June 17, 2019; doi:10.21926/obm.geriatr.1902056

Abstract: Alzheimer’s Disease is increasingly seen as the major health in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The perva [...]

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Terence Seedsman
Received: January 29, 2019; Published: May 24, 2019; doi:10.21926/obm.geriatr.1902055

Abstract: The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Research inv [...]

Open Access Original Research

Empirical Examination of Caregiving Processes and Outcomes among Adult Siblings of Individuals with Intellectual and Developmental Disabilities

Mamta Saxena, Anne F. Farrell, Kari Adamsons
Received: February 25, 2019; Published: May 20, 2019; doi:10.21926/obm.geriatr.1902054

Abstract: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. In this study, we examined caregiving processes [...]

Open Access Review

Admiral Nurse Case Management: A Model of Caregiver Support for Families Affected by Dementia

Karen Harrison Dening, Zena Aldridge
Received: February 26, 2019; Published: May 10, 2019; doi:10.21926/obm.geriatr.1902053

Abstract: People with dementia do not exist in isolation and whilst there has been a strong thrust to identify the needs of people with dementia against a background of person centred care, they live within relational contexts with family members. Case management is a model of care that can support the care [...]

Open Access Research Article

The Relationship between Caregiver Stress and Behavioural Changes in Dementia

Lindy A. Kilik, Robert W. Hopkins
Received: March 01, 2019; Published: May 09, 2019; doi:10.21926/obm.geriatr.1902052

Abstract: Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston [...]

Open Access Concept Paper

Biological Age versus Chronological Age in the Prevention of Age Associated Diseases

Gian Andrea Rollandi, Aldo Chiesa, Nicoletta Sacchi, Mauro Castagnetta, Matteo Puntoni, Adriana Amaro, Barbara Banelli, Ulrich Pfeffer
Received: January 31, 2019; Published: May 05, 2019; doi:10.21926/obm.geriatr.1902051

Abstract: Aging is associated with an increasing incidence of major diseases among which cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome and quality of life and are commonly appl [...]

Open Access Project Report

An Evaluation of a Community-Based Psychoeducation Program for Successful Ageing

Claire L. Thompson , Daniela Calafiore, Julijana Chochovski, Steven Trawley, Kathryn von Treuer
Received: October 29, 2018; Published: April 26, 2019; doi:10.21926/obm.geriatr.1902050

Abstract: (1) Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to [...]

Open Access Original Research

Moderators of Treatment Outcomes from Family Caregiver Skills Training: Secondary Analysis of a Randomized Controlled Trial

Michael P. Cary, Jr., Valerie A. Smith, Megan Shepherd-Banigan, Jennifer H. Lindquist, Jennifer G. Chapman, Susan N. Hastings, Courtney H. Van Houtven
Received: February 22, 2019; Published: April 18, 2019; doi:10.21926/obm.geriatr.1902049

Abstract: Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and care [...]

OBM Geriatrics welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

Register and Submit now.

Newsletter

TOP