The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage
Hideki Kanamaru , Fumihiro Kawakita , Reona Asada , Hidenori Suzuki *
Department of Neurosurgery, Mie University Graduate School of Medicine, 745-54 Edobashi, Tsu, Mie 514-8507, Japan
* Correspondence: Hidenori Suzuki
Academic Editors: Lynne Ann Barker and Leanne Greene
Special Issue: New Developments in Brain Injury
Received: May 07, 2019 | Accepted: July 18, 2019 | Published: July 29, 2019
OBM Neurobiology 2019, Volume 3, Issue 3, doi:10.21926/obm.neurobiol.1903035
Recommended citation: Kanamaru H, Kawakita F, Asada R, Suzuki H. The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage. OBM Neurobiology 2019; 3(3): 035; doi:10.21926/obm.neurobiol.1903035.
© 2019 by the authors. This is an open access article distributed under the conditions of the Creative Commons by Attribution License, which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is correctly cited.
Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury, and its mechanisms have not been completely unraveled so far. The causative factors for the brain injury initiated by an aneurysm rupture, which is referred to as the early brain injury (EBI), include elevated intracranial pressure, cerebral hypoperfusion, and blood contents that are directly exposed to the brain surface. At Day 4–14 post aSAH, delayed cerebral ischemia (DCI) often develops, which may worsen the neurological outcomes critically. DCI may be a consequence of EBI. Understanding the complex mechanisms underlying the post-aSAH brain injury (EBI and DCI) is, therefore, important in order to improve the neurological outcomes. In addition, several biomarkers possibly associated with EBI, DCI, and neurological outcome have been investigated, although none of these has been conclusive. A matricellular protein periostin has emerged as an important potential contributor to EBI and DCI, and may serve as the biomarker and a therapeutic molecular target for EBI and DCI. In the present report, the possible role of periostin in aSAH has been reviewed.
Periostin; subarachnoid hemorrhage; early brain injury; delayed cerebral ischemia; biomarker
1.1 Epidemiology of Subarachnoid Hemorrhage (SAH)
Aneurysmal SAH (aSAH) is one among several hemorrhagic strokes, which often results in severe neurological disorder, and even death . Aneurysm rupture causes the blood components to spread into the subarachnoid space and initiates various pathological conditions . The incidence of aSAH, which varies with region, falls in the range of 2–16 cases per 100,000 people . The risk factors for aSAH are older age, residing in particular regions (especially in Finland and Japan), female sex, family history, certain genetic syndromes, history of hypertension, use of tobacco, alcohol abuse, sympathomimetic drugs such as cocaine, and the association of unruptured intracranial aneurysms . Larger size, a particular location (such as anterior and posterior communicating arteries), and irregular shape of the unruptured intracranial aneurysms constitute the positive factors for the risk of rupture [1,4,5]. The major predictors of poor outcome in aSAH are initial clinical severity—which is evaluated using a clinical scale such as Hunt and Hess scale or using the World Federation of Neurological Surgeons grades—and rebleeding or premature rupture prior to aneurysmal obliteration through clipping or endovascular coiling . Other clinical factors associated with poor outcome in aSAH include older age, a previous medical history, cerebral vasospasm, delayed cerebral infarction, and systemic complications [1,6]. Therefore, providing intensive care for managing these clinical factors is crucial in aSAH treatment.
1.2 Early Brain Injury (EBI) and Delayed Cerebral Ischemia (DCI) in aSAH
Aneurysm rupture causes multiple pathological changes in the brain environment [7,8]. Elevation in the intracranial pressure, cerebral hypoperfusion, global cerebral ischemia, and spreading of the blood contents into the subarachnoid space occur after the aneurysm rupture, and these events, whether transient or persistent, induce EBI . EBI further activates multiple cellular and molecular events, including the inflammatory, apoptotic, or necrotic cell death pathways, in the brain capillary endothelial, glial, and neuronal cells . Apoptosis of the brain capillary endothelial cells, along with the other causes of neurovascular unit injury, leads to disruption of the blood-brain barrier, which exposes the brain tissues directly to harmful blood contents and immune cells, exacerbating the EBI further . Since the aneurysmal rebleeding worsens the brain damage and neurological outcomes, early aneurysmal obliteration through clipping or endovascular coiling is the crucial first step in aSAH treatment. However, even if the aneurysmal obliteration is performed successfully and the patient is having good initial clinical conditions, delayed neurological disorder may occur. Delayed neurological disorder comprises DCI and other conditions such as hydrocephalus and systemic complications. The latter may be diagnosed using clinical assessments, including chest X-ray, brain computed tomography, magnetic resonance imaging, and laboratory examinations . The already-known pathogeneses of DCI include cerebral vasospasm, inflammation, microthrombosis, and cortical spreading ischemia , and a measure of intracranial hematoma is one of the strong predictors of DCI . Cerebral vasospasm has been considered as the main player in DCI for a long time, although the drugs targeting cerebral vasospasm have failed to cause any improvement in the neurological outcomes . Therefore, nowadays, cerebral vasospasm is believed to be only a part of DCI, and EBI and the non-vasospastic causes of DCI are recognized as the more important determinants of neurological outcomes [5,14]. In order to predict or understand DCI, several biomarkers, such as the inflammatory, metabolic, vascular, coagulation cascade-related, genetic, oxidative stress-related, ischemic, hemoglobin breakdown products, brain injury-related, and diverse pathways-related ones, have been investigated, although the evidence levels have been low . Recently, machine learning analyses have demonstrated that the measurement of plasma periostin at an acute stage is the most important feature for the prediction of DCI among the various clinical factors including the established predictors according to the World Federation of Neurological Surgeons and Fisher grades .
The extracellular matrix (ECM) proteins are part of a dynamic structural network, and modulate the tissue microenvironment and maintain homeostasis [17,18]. Periostin is one of the several matricellular proteins, which are a group of secretory non-structural ECM proteins [17,18]. Matricellular proteins including periostin are present in low levels in most of the adult tissues in normal conditions and are highly expressed in the injured or inflamed tissues [17,18]. Periostin, a protein approximately 90 kDa in size, was originally reported in 1993 as an osteoblast-specific factor-2 in a mouse osteoblastic cell line . Periostin has a typical sequence, consisting of an amino-terminal cysteine-rich EMI domain, a tandem repeat of four Fasciclin-1 domains, and a carboxyl-terminal hydrophilic domain (Figure 1) . The EMI domain potentially binds to other ECM proteins such as collagen (types I and V), fibronectin, and a matricellular protein βig-h3 (also known as keratoepithelin, RGD-CAP, or transforming growth factor [TGF]-β-induced protein), and it is essential for the multimerization of periostin from a dimer to a hexamer [20,21,22]. The four Fasciclin-1 domains bind to a pro-collagen C-proteinase (i.e., bone morphogenetic protein (BMP)-1), matricellular proteins tenascin-C, cellular communication network factor 3 (also referred to nephroblastoma overexpressed), and integrins [21,22,23,24,25]. The carboxyl-terminal domain binds to heparin and proteoglycan . The gene that codes for the carboxyl-terminal domain comprises 9 exons (exon 15 to exon 23) and the alternative splicing that deletes certain exons occurs between exons 17 and 21 . The carboxyl-terminal domain inhibits the interaction of the Fasciclin-1 domains with tenascin-C . This interaction requires the cleavage of the carboxyl-terminal domain by the matrix metalloproteases (MMPs) MMP-2 and MMP-9 . The variations in the cleavage allow periostin to have different functional roles [26,27].
Periostin is known to be induced by various stimuli, such as interleukin (IL)-4, IL-13, TGF-β1, TGF-β3, fibroblast growth factor 1, connective tissue growth factor 2, angiotensin II, BMP-2, platelet-derived growth factor, and mechanical stretch and cancer-derived factors. Periostin is also known to activate downstream signals, including focal adhesion kinase (FAK), phosphoinositide 3-kinase, protein kinase B (Akt), extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38, nuclear factor (NF)-κB, signal transducers and activator of transcription (STAT) 3, and mammalian target of rapamycin (mTOR), possibly via integrins (αvβ1, αvβ3, αvβ5, α6β4, and αMβ2) [18,20,22,24,28], resulting in the regulation of cell adhesion, migration, proliferation, signaling, and phenotype [25,29]. Additionally, periostin is known to remodel the local tissue microenvironment through the recruitment of Wnt, Notch1, or other ligands, leading to the modulation of their signaling .
Figure 1 The structure and binding partners of periostin. BMP: bone morphogenetic protein; CCN: cellular communication network factor; FAS: fasciclin.
2.1 Periostin in Various Disorders
Recently, investigations regarding periostin have revealed that it plays important roles in a diverse set of diseases, by contributing to tissue injury, inflammation, fibrosis, and tumor progression (Figure 2) [18,30]. The investigations regarding periostin may assist in understanding the functions and mechanisms of periostin, and therefore, in developing novel therapies for the associated pathologies. For instance, periostin has been implicated in the process of skin wound healing by serving as both an ECM and a matricellular protein [28,29]. Periostin has also been reported to be upregulated and deposited in chronic inflammation sites associated with fibrosis, and to further augment the inflammatory reactions through the activation of both immune and non-immune cells by serving as a matricellular protein. Periostin is a critical player in the inflammatory microenvironment in various diseases such as asthma , atopic dermatitis , chronic rhinosinusitis with nasal polyp , allergic conjunctivitis , atherosclerosis , scleroderma , and pulmonary fibrosis . Izuhara et al. reported that ILs-4 and ILs-13 were able to activate the NF-κB pathway in the fibroblasts and promote periostin expression . As NF-κB is expressed extensively along with multiple inflammatory cytokines in aSAH , it is compatible that periostin is upregulated with the NF-κB activation in aSAH as in other pathologies [2,39]. In order to conduct the mechanisms underlying the fibrotic diseases with inflammation, the cross-talk between periostin and TGF-β or the pro-inflammatory cytokines may be important . In the process of development of atherosclerosis, periostin is mainly secreted by the infiltrating inflammatory cells and myofibroblasts. This, in turn, causes the advancement of the atherosclerotic degeneration and progression by promoting angiogenesis via Akt and FAK pathways, by upregulating MMP-2, MMP-9, and MMP-13, as well as by facilitating vascular smooth muscle cell migration through the activation of FAK by binding to the αvβ3 and αvβ5 integrins . Periostin may serve as a marker of tumor progression, metastasis, angiogenesis, and poor prognosis in several types of human cancers or malignancies, including carcinomas of liver , head/neck , pancreas , breast , colon , esophagus , and ovary , and is believed to promote a tumor-supportive microenvironment [18,25,47]. For instance, periostin may cooperate with mutant p53 in case of tumor invasion through the STAT1 pathway in esophageal tumor , and binds to integrins α5 and β1 in order to activate the phosphoinositide 3-kinase/Akt pathway to promote tumor cell survival, migration, invasion, and angiogenesis in case of invasion by cholangiocarcinoma . Periostin also plays an important role in diseases associated with the cardiovascular and central nervous systems. In cardiac diseases, periostin has been demonstrated to activate the integrin-associated p38, FAK, and phosphoinositide 3-kinase/Akt and Wnt/β-catenin signaling cascades in fibroblasts and vascular smooth muscle cells . In addition, TGF-β in association with the subunits of the αv integrin is released as a result of mechanical stress, rendering the integrins available for interaction with periostin, which in turn may initiate a feed-forward loop of periostin signaling . In a rat model of acute myocardial infarction, overexpression of full-length periostin was reported to be associated with ventricular dilatation along with collagen deposition, while the splicing variants of periostin (a variant of periostin lacking exon 17 and another one lacking exons 17 and 21) were reported to be associated with myocardial repair . In a mouse model of cerebral ischemia, the administration of exogenous periostin lacking exon 2 was demonstrated to provide neuroprotection . Owing to the findings stated above, periostin has received great attention as a biomarker for the prediction or monitoring of disease progression and treatment effects, and as a therapeutic target against several diseases . The matricellular protein periostin may serve as an ideal biomarker because of its involvement in the pathogenesis of a disease, and the ability to conveniently measure its levels in the peripheral blood similar to other matricellular proteins [52,53,54]. In patients with severe traumatic brain injury, detection of higher levels of serum periostin at admission predicted 30-day mortality with high sensitivity and high specificity . Serum periostin levels were also measured in acute spontaneous intracerebral hemorrhage patients, in which increased periostin levels correlated well with the hematoma volume and neurological severity .
Figure 2 Potential roles of periostin in various diseases. FAK: focal adhesion kinase; IL: interleukin; MMP: matrix metalloprotease; NF: nuclear factor; PI3K: phosphoinositide 3-kinase; STAT: signal transducers and activator of transcription; TGF: transforming growth factor; VSMC: vascular smooth muscle cell.
2.2 Periostin in SAH in Experimental and Clinical Settings
Inflammatory reactions have been implicated in both EBI and DCI in consequence to aSAH [2,7]. After the rupture of a cerebral aneurysm, transient global cerebral ischemia and extravasation of blood components occur, inducing several inflammatory cascades, which may cause and aggravate EBI, and possibly lead to the development of DCI [2,7]. It is believed that the endogenous ligands having damage-associated molecular patterns, such as heme, fibrinogen, and intracellular components released at the site of tissue injuries, activate a pattern recognition receptor named Toll-like receptor (TLR)-4, as an initial step of the inflammatory cascades induced in response to brain injuries (EBI and subsequently DCI) after SAH. TLR-4 is expressed in most of the cells in the brain and the cerebral arterial wall, as well as in the inflammatory cells and platelets, and has been reported to induce maximal inflammatory response among all the TLR family members (Figure 3) [2,7,57]. TLR-4 activates both NF-κΒ and mitogen-activated protein kinase (p38, ERK, and JNK) pathways, and induces various pro-inflammatory factors such as ILs, MMP-9, reactive oxygen species, and matricellular proteins including tenascin-C and periostin [2,7,58]. Among the matricellular proteins, periostin and tenascin-C positively affect each other’s function and expression levels , and tenascin-C and galectin-3 are known to be the ligands of TLR-4 [7,60]. Therefore, the matricellular proteins including periostin may be playing at least partial roles, if not complete roles, in forming positive feedback loops for further activation of TLR-4 signaling. Certain experimental studies have demonstrated that TLR-4 is involved in neuroinflammation, blood-brain barrier disruption, neuronal apoptosis, and cerebral vasospasm, all of which are potential pathologies underlying EBI and/or DCI after SAH [2,58,60,61].
In a previous study conducted by our research group on mice, it was demonstrated that the periostin expression was remarkably increased in the neurons and brain capillary endothelial cells post-SAH through the endovascular perforation, which is believed to simulate clinical SAH . In that study, immunohistochemical analyses were not performed, and therefore, periostin expression in the other cells was not examined, although several other cells including microglia, astrocytes, endothelial and smooth muscle cells of cerebral arteries, and the peripheral blood cells such as leukocytes, macrophages, and platelets were observed to be potentially involved in the pathophysiology of post-SAH EBI and DCI, reflecting the complex mechanisms underlying these conditions [2,7,8]. In regard to the potential involvement of other cells in relation to periostin expression, further studies are required. Neutralization of full-length periostin was reported to inhibit the post-SAH activation of p38 and ERK1/2, as well as the post-SAH upregulation of MMP-9 and tenascin-C, resulting in a less severe form of EBI in terms of neuroscore, brain edema, and blood-brain barrier permeability . In the same study, JNK activation was not observed , while the other studies conducted using the same model reported the involvement of JNK in blood-brain barrier disruption . Since the administration of recombinant full-length periostin was reported to reaggravate EBI , it was believed that periostin at least caused blood-brain barrier disruption through MMP-9 activation, and also the resultant degradation of the ECM proteins, which comprised the components of blood-brain barrier, through the activation of p38 and ERK1/2 [59,62]. In addition, periostin and tenascin-C were observed to regulate the expression levels of each other, in correlation with the severity of the post-SAH blood-brain barrier disruption . Tenascin-C has been repeatedly reported to contribute to the development of neuroinflammation, blood-brain barrier disruption, neuronal apoptosis, and cerebral vasospasm after experimental SAH [62,63,64,65]. The aforementioned findings suggest that either periostin causes EBI and DCI through the regulation of tenascin-C expression, and the converse is also true, or that both periostin and tenascin-C separately cause these conditions.
In clinical settings, Luo et al. measured the serum periostin levels at admission and reported that higher levels of serum periostin were associated with a poorer clinical grade at admission, higher frequency of development of DCI, and worse neurological outcomes in the aSAH patients . In a recent study conducted by our research group, plasma periostin levels were chronologically measured 4 times during the period between the post-operative or post-interventional Day 1 and post-aSAH Day 12; the plasma periostin levels were observed to peak at Day 4–6 after onset, and later, development of DCI was observed . Although periostin is a kind of inflammatory marker , the study revealed that the plasma periostin levels exhibited no correlation with the serum levels of a systemic inflammatory marker named C-reactive protein . However, cerebrospinal fluid drainage was observed to significantly lower the plasma periostin levels at all time points of measurement, possibly because the drainage of cerebrospinal fluid removed periostin before the latter moved from the brain extracellular fluid or the cerebrospinal fluid to peripheral blood . Multivariate logistic regression analyses conducted using all the clinical variables by Day 3 post-aSAH demonstrated that the plasma periostin levels at Days 1-3 post-aSAH (post-operative or post-interventional Day 1) served as an independent predictor of DCI, irrespective of the subsequent development of cerebral vasospasm . At present, the commercially available enzyme-linked immunosorbent assay kits are able to measure the concentration of four well-known splicing variants of periostin (a full-length variant containing all 9 exons; a variant lacking exon 17; a variant lacking exon 21; and a variant lacking exons 17 and 21) together, although a separate measurement is not possible with these kits yet .
Figure 3 Toll-like receptor (TLR) 4-mediated inflammatory reactions in early brain injury (EBI) and delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). IL: interleukin; MCP: matricellular protein; MAPK: mitogen-activated protein kinase; MMP: matrix metalloprotease; NF: nuclear factor; ROS: reactive oxygen species.
3. Potential Limitations
Severe aSAH is well-known for causing systemic inflammatory response syndrome and extracerebral multiple organ dysfunction including respiratory, renal, hepatic, cardiovascular, and hematologic organ dysfunctions occurring due to sympathetic storm and catecholamine surge [67,68,69]. aSAH has also been reported to be probably associated with intracranial as well as systemic infections . The severity of complications, such as extracerebral organ system dysfunctions and inflammation, has been reported to be correlated with the degree of neurological impairments in a graded fashion . The extracranial complications not only exert direct effects on the clinical outcomes, but they may also exacerbate the intracranial complications including brain injuries . Therefore, it is important to monitor, recognize, and manage these complications in parallel with the intracranial complications, thereby allowing the optimization of the management of aSAH patients, leading to improvement in the overall outcomes. However, as described earlier in the present report, since periostin may be upregulated by a number of stimuli and interacts with several molecules [20,21,22,23,24,25], it may be difficult to identify the tissues or pathologies from which the observed increases in the plasma periostin levels might be originating. This implies potential limitations such as determining the specificity when applying periostin as a biomarker for predicting or monitoring the clinical events in the aSAH patients. In order to overcome these issues, it may become necessary to clarify the different roles of each isoform of periostin along with its distribution in tissues after aSAH, and to develop the methods that can detect the different isoforms of periostin in the peripheral blood. Using combinations of periostin isoforms and the other biomarkers reflecting different pathologies might prove to be reliable biomarkers for the diagnosis of complex intracranial and extracranial complications associated with aSAH in the near future.
The role of periostin in aSAH is not well understood so far. Nonetheless, the information available in the literature suggests important roles of periostin in aSAH. Recently, it has become apparent that the pathogenesis underlying EBI and DCI is complex, and includes multiple pathophysiologies. However, in aSAH patients, no established methods, other than angiographic vasospasm and cortical spreading depolarization, are available for the diagnosis or prediction of individual pathophysiology in a clinical setting . Recently, in preclinical studies, positron emission tomography (PET) was used to detect the relationships between the brain metabolisms and EBI after SAH or ischemic brain injury [70,71]. In addition, a PET tracer specifically targeting periostin was developed, which allowed the specific imaging of periostin in the mouse models of esophageal squamous cell carcinoma [30,72]. In the near future, detection of periostin in the post-SAH brain using PET could assist in the early detection, follow-up, and in-situ characterization of EBI and DCI.
Although further investigations are required, it would be useful if the plasma periostin levels could be utilized to predict the individual etiology of EBI and DCI, to diagnose the ongoing ones, and to monitor the effects of the treatments applied for them. In particular, the post-aSAH roles of periostin isoforms resulting from alternative splicing or cleavage by a protease have never been examined. Since the different isoforms may be having opposite functions, further studies including the time course of induction of each isoform and the relationships of these isoforms with the underlying mechanisms of EBI and DCI are required to provide novel insights into the matter . Periostin is also interesting as a therapeutic target. The treatment target could be periostin itself, or the receptor integrins and the related molecules. In order to inhibit the post-aSAH induction of a representative of the periostin-related protein tenascin-C, cilostazol was used in a clinical setting of aSAH and promising efficacy was found [73,74]. In consideration of the diverse signal transduction associated with periostin, it is believed that periostin may be involved in multiple pathophysiologies other than the blood-brain barrier disruption in aSAH. Since there is no doubt that periostin is one of the critical regulators of the mechanisms underlying EBI and DCI, further experimental and clinical studies would lead to the development of novel therapies that would improve the neurological outcomes after aSAH.
We thank Ms. Chiduru Nakamura (Department of Neurosurgery, Mie University Graduate School of Medicine) for her administrative help.
HK, FK, RA and HS wrote, reviewed and approved the final version of the manuscript.
This work was funded by a grant-in-aid for Scientific Research from Japan Society for the Promotion of Science (grant number: 17K10825) to Dr. Suzuki.
The authors have declared that no competing interests exist.
- Connolly ES Jr., Rabinstein AA, Carhuapoma JR, Derdeyn CP, Dion J, Higashida RT, et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2012; 43: 1711-1737. [CrossRef]
- Okada T, Suzuki H. Toll-like receptor 4 as a possible therapeutic target for delayed brain injuries after aneurysmal subarachnoid hemorrhage. Neural Regen Res. 2017; 12: 193-196. [CrossRef]
- Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: A systematic review. Lancet Neurol. 2009; 8: 355-369. [CrossRef]
- Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, Hashimoto N, et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012; 366: 2474-2482. [CrossRef]
- Kanamaru H, Suzuki H. Potential therapeutic molecular targets for blood-brain barrier disruption after subarachnoid hemorrhage. Neural Regen Res. 2019; 14: 1138-1143. [CrossRef]
- Suzuki H, Shiba M, Nakatsuka Y, Nakano F, Nishikawa H. Higher cerebrospinal fluid pH may contribute to the development of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Transl Stroke Res. 2017; 8: 165-173. [CrossRef]
- Suzuki H, Fujimoto M, Kawakita F, Liu L, Nakatsuka Y, Nakano F, et al. Tenascin-C in brain injuries and edema after subarachnoid hemorrhage: findings from basic and clinical studies. J Neurosci Res. 2018. doi: 10.1002/jnr.24330. [CrossRef]
- Nishikawa H, Suzuki H. Possible role of inflammation and galectin-3 in brain injury after subarachnoid hemorrhage. Brain Sci. 2018; 8: 30. [CrossRef]
- Sabri M, Lass E, Macdonald RL. Early brain injury: A common mechanism in subarachnoid hemorrhage and global cerebral ischemia. Stroke Res Treat. 2013; 2013: 394036. [CrossRef]
- Vergouwen MD, Vermeulen M, van Gijn J, Rinkel GJ, Wijdicks EF, Muizelaar JP, et al. Definition of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage as an outcome event in clinical trials and observational studies: Proposal of a multidisciplinary research group. Stroke. 2010; 41: 2391-2395. [CrossRef]
- Vergouwen MD, Vermeulen M, Coert BA, Stroes ES, Roos YB. Microthrombosis after aneurysmal subarachnoid hemorrhage: An additional explanation for delayed cerebral ischemia. J Cereb Blood Flow Metab. 2008; 28: 1761-1770. [CrossRef]
- van der Steen WE, Zijlstra IA, Verbaan D, Boers AMM, Gathier CS, van den Berg R, et al. Association of quantified location-specific blood volumes with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. AJNR Am J Neuroradiol. 2018; 39: 1059-1064. [CrossRef]
- Suzuki H, Nakano F. To improve translational research in subarachnoid hemorrhage. Transl Stroke Res. 2018; 9: 1-3. [CrossRef]
- Nakano F, Kawakita F, Liu L, Nakatsuka Y, Nishikawa H, Okada T, et al. Anti-vasospastic effects of epidermal growth factor receptor inhibitors after subarachnoid hemorrhage in mice. Mol Neurobiol. 2019: 56: 4730-4740. [CrossRef]
- Jabbarli R, Pierscianek D, Darkwah Oppong M, Sato T, Dammann P, Wrede KH, et al. Laboratory biomarkers of delayed cerebral ischemia after subarachnoid hemorrhage: A systematic review. Neurosurg Rev. 2018: 1-9. [CrossRef]
- Tanioka S, Ishida F, Nakano F, Kawakita F, Kanamaru H, Nakatsuka Y, et al. Machine learning analysis of matricellular proteins and clinical variables for early prediction of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Mol Neurobiol. 2019. doi: 10.1007/s12035-019-1601-7. [CrossRef]
- Kii I. Periostin functions as a scaffold for assembly of extracellular proteins. Adv Exp Med Biol. 2019; 1132: 23-32. [CrossRef]
- Liu AY, Zheng H, Ouyang G. Periostin, a multifunctional matricellular protein in inflammatory and tumor microenvironments. Matrix Biol. 2014; 37: 150-156. [CrossRef]
- Takeshita S, Kikuno R, Tezuka K, Amann E. Osteoblast-specific factor 2: Cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I. Biochem J. 1993; 294: 271-278. [CrossRef]
- Kudo A. Introductory review: Periostin-gene and protein structure. Cell Mol Life Sci. 2017; 74: 4259-4268. [CrossRef]
- Kii I, Nishiyama T, Li M, Matsumoto K, Saito M, Amizuka N, et al. Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture. J Biol Chem. 2010; 285: 2028-2039. [CrossRef]
- Kii I, Ito H. Periostin and its interacting proteins in the construction of extracellular architectures. Cell Mol Life Sci. 2017; 74: 4269-4277. [CrossRef]
- Suresh A, Biswas A, Perumal S, Khurana S. Periostin and integrin signaling in stem cell regulation. Adv Exp Med Biol. 2019; 1132: 163-176. [CrossRef]
- Kudo A, Kii I. Periostin function in communication with extracellular matrices. J Cell Commun Signal. 2018; 12: 301-308. [CrossRef]
- Viloria K, Hill NJ. Embracing the complexity of matricellular proteins: The functional and clinical significance of splice variation. Biomol Concepts. 2016; 7: 117-132. [CrossRef]
- Hoersch S, Andrade-Navarro MA. Periostin shows increased evolutionary plasticity in its alternatively spliced region. BMC Evol Biol. 2010; 10: 30. [CrossRef]
- Nishikawa H, Suzuki H. Implications of periostin in the development of subarachnoid hemorrhage-induced brain injuries. Neural Regen Res. 2017; 12: 1982-1984. [CrossRef]
- Izuhara K, Nunomura S, Nanri Y, Ogawa M, Ono J, Mitamura Y, et al. Periostin in inflammation and allergy. Cell Mol Life Sci. 2017; 74: 4293-4303. [CrossRef]
- Walker JT, McLeod K, Kim S, Conway SJ, Hamilton DW. Periostin as a multifunctional modulator of the wound healing response. Cell Tissue Res. 2016; 365: 453-465. [CrossRef]
- Kii I. Practical application of periostin as a biomarker for pathological conditions. Adv Exp Med Biol. 2019; 1132: 195-204. [CrossRef]
- Matsusaka M, Kabata H, Fukunaga K, Suzuki Y, Masaki K, Mochimaru T, et al. Phenotype of asthma related with high serum periostin levels. Allergol Int. 2015; 64: 175-180. [CrossRef]
- Kou K, Okawa T, Yamaguchi Y, Ono J, Inoue Y, Kohno M, et al. Periostin levels correlate with disease severity and chronicity in patients with atopic dermatitis. Br J Dermatol. 2014; 171: 283-291. [CrossRef]
- Wang M, Wang X, Zhang N, Wang H, Li Y, Fan E, et al. Association of periostin expression with eosinophilic inflammation in nasal polyps. J Allergy Clin Immunol. 2015; 136: 1700-1703.e9. [CrossRef]
- Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, et al. The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. J Allergy Clin Immunol. 2016; 138: 459-467.e2. [CrossRef]
- Schwanekamp JA, Lorts A, Vagnozzi RJ, Vanhoutte D, Molkentin JD. Deletion of periostin protects against atherosclerosis in mice by altering inflammation and extracellular matrix remodeling. Arterioscler Thromb Vasc Biol. 2016; 36: 60-68. [CrossRef]
- Yamaguchi Y, Ono J, Masuoka M, Ohta S, Izuhara K, Ikezawa Z, et al. Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. Br J Dermatol. 2013; 168: 717-725. [CrossRef]
- Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, et al. Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012; 46: 677-686. [CrossRef]
- Pang J, Chen Y, Kuai L, Yang P, Peng J, Wu Y, et al. Inhibition of blood-brain barrier disruption by an apolipoprotein E-mimetic peptide ameliorates early brain injury in experimental subarachnoid hemorrhage. Transl Stroke Res. 2017; 8: 257-272. [CrossRef]
- Kanamaru H, Kawakita F, Nakano F, Miura Y, Shiba M, Yasuda R, et al. Plasma periostin and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Neurotherapeutics. 2019; 16: 480-490. [CrossRef]
- Lv Y, Wang W, Jia WD, Sun QK, Huang M, Zhou HC, et al. High preoparative levels of serum periostin are associated with poor prognosis in patients with hepatocellular carcinoma after hepatectomy. Eur J Surg Oncol. 2013; 39: 1129-1135. [CrossRef]
- Kudo Y, Ogawa I, Kitajima S, Kitagawa M, Kawai H, Gaffney PM, et al. Periostin promotes invasion and anchorage-independent growth in the metastatic process of head and neck cancer. Cancer Res. 2006; 66: 6928-6935. [CrossRef]
- Erkan M, Kleeff J, Gorbachevski A, Reiser C, Mitkus T, Esposito I, et al. Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology. 2007; 132: 1447-1464. [CrossRef]
- Shao R, Bao S, Bai X, Blanchette C, Anderson RM, Dang T, et al. Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. Mol Cell Biol. 2004; 24: 3992-4003. [CrossRef]
- Bao S, Ouyang G, Bai X, Huang Z, Ma C, Liu M, et al. Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway. Cancer Cell. 2004; 5: 329-339. [CrossRef]
- Wong GS, Lee JS, Park YY, Klein-Szanto AJ, Waldron TJ, Cukierman E, et al. Periostin cooperates with mutant p53 to mediate invasion through the induction of STAT1 signaling in the esophageal tumor microenvironment. Oncogenesis. 2013; 2: e59. [CrossRef]
- Gillan L, Matei D, Fishman DA, Gerbin CS, Karlan BY, Chang DD. Periostin secreted by epithelial ovarian carcinoma is a ligand for αVβ3 and αVβ5 integrins and promotes cell motility. Cancer Res. 2002; 62: 5358-5364.
- Hu F, Shang XF, Wang W, Jiang W, Fang C, Tan D, et al. High-level expression of periostin is significantly correlated with tumour angiogenesis and poor prognosis in osteosarcoma. Int J Exp Pathol. 2016; 97: 86-92. [CrossRef]
- Utispan K, Sonongbua J, Thuwajit P, Chau-In S, Pairojkul C, Wongkham S, et al. Periostin activates integrin α5β1 through a PI3K/AKT-dependent pathway in invasion of cholangiocarcinoma. Int J Oncol. 2012; 41: 1110-1118. [CrossRef]
- Landry NM, Cohen S, Dixon IMC. Periostin in cardiovascular disease and development: A tale of two distinct roles. Basic Res Cardiol. 2018; 113: 1. [CrossRef]
- Taniyama Y, Katsuragi N, Sanada F, Azuma J, Iekushi K, Koibuchi N, et al. Selective blockade of periostin exon 17 preserves cardiac performance in acute myocardial infarction. Hypertension. 2016; 67: 356-361. [CrossRef]
- Shimamura M, Taniyama Y, Katsuragi N, Koibuchi N, Kyutoku M, Sato N, et al. Role of central nervous system periostin in cerebral ischemia. Stroke. 2012; 43: 1108-1114. [CrossRef]
- Nishikawa H, Nakatsuka Y, Shiba M, Kawakita F, Fujimoto M, Suzuki H. Increased plasma galectin-3 preceding the development of delayed cerebral infarction and eventual poor outcome in non-severe aneurysmal subarachnoid hemorrhage. Transl Stroke Res. 2018; 9: 110-119. [CrossRef]
- Nakatsuka Y, Shiba M, Nishikawa H, Terashima M, Kawakita F, Fujimoto M, et al. Acute-phase plasma osteopontin as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage. Mol Neurobiol. 2018; 55: 6841-6849. [CrossRef]
- Suzuki H, Nishikawa H, Kawakita F. Matricellular proteins as possible biomarkers for early brain injury after aneurysmal subarachnoid hemorrhage. Neural Regen Res. 2018; 13: 1175-1178. [CrossRef]
- Dong XQ, Yu WH, Du Q, Wang H, Zhu Q, Yang DB, et al. Serum periostin concentrations and outcomes after severe traumatic brain injury. Clin Chim Acta. 2017; 471: 298-303. [CrossRef]
- Ji WJ, Chou XM, Wu GQ, Shen YF, Yang XG, Wang ZF, et al. Association between serum periostin concentrations and outcome after acute spontaneous intracerebral hemorrhage. Clin Chim Acta. 2017; 474: 23-27. [CrossRef]
- Suzuki H. Inflammation: A good research target to improve outcomes of poor-grade subarachnoid hemorrhage. Transl Stroke Res. 2019. doi: 10.1007/s12975-019-00713-y. [CrossRef]
- Okada T, Kawakita F, Nishikawa H, Nakano F, Liu L, Suzuki H. Selective Toll-like receptor 4 antagonists prevent acute blood-brain barrier disruption after subarachnoid hemorrhage in mice. Mol Neurobiol. 2019; 56: 976-985. [CrossRef]
- Liu L, Kawakita F, Fujimoto M, Nakano F, Imanaka-Yoshida K, Yoshida T, et al. Role of periostin in early brain injury after subarachnoid hemorrhage in mice. Stroke. 2017; 48: 1108-1111. [CrossRef]
- Nishikawa H, Liu L, Nakano F, Kawakita F, Kanamaru H, Nakatsuka Y, et al. Modified citrus pectin prevents blood-brain barrier disruption in mouse subarachnoid hemorrhage by inhibiting galectin-3. Stroke. 2018; 49: 2743-2751. [CrossRef]
- Kawakita F, Fujimoto M, Liu L, Nakano F, Nakatsuka Y, Suzuki H. Effects of Toll-like receptor 4 antagonists against cerebral vasospasm after experimental subarachnoid hemorrhage in mice. Mol Neurobiol. 2017; 54: 6624-6633. [CrossRef]
- Fujimoto M, Shiba M, Kawakita F, Liu L, Shimojo N, Imanaka-Yoshida K, et al. Deficiency of tenascin-C and attenuation of blood-brain barrier disruption following experimental subarachnoid hemorrhage in mice. J Neurosurg. 2016; 124: 1693-1702. [CrossRef]
- Fujimoto M, Shiba M, Kawakita F, Liu L, Shimojo N, Imanaka-Yoshida K, et al. Effects of tenascin-C knockout on cerebral vasospasm after experimental subarachnoid hemorrhage in mice. Mol Neurobiol. 2018; 55: 1951-1958. [CrossRef]
- Liu L, Fujimoto M, Nakano F, Nishikawa H, Okada T, Kawakita F, et al. Deficiency of tenascin-C alleviates neuronal apoptosis and neuroinflammation after experimental subarachnoid hemorrhage in mice. Mol Neurobiol. 2018; 55: 8346-8354. [CrossRef]
- Shiba M, Suzuki H. Lessons from tenascin-C knockout mice and potential clinical application to subarachnoid hemorrhage. Neural Regen Res. 2019; 14: 262-264. [CrossRef]
- Luo W, Wang H, Hu J. Increased concentration of serum periostin is associated with poor outcome of patients with aneurysmal subarachnoid hemorrhage. J Clin Lab Anal. 2018; 32: e22389. [CrossRef]
- Nasr DM, Tomasini S, Prasad A, Rabinstein AA. Acute brain diseases as triggers for stress cardiomyopathy: Clinical characteristics and outcomes. Neurocrit Care. 2017; 27: 356-361. [CrossRef]
- Gruber A, Reinprecht A, Illievich UM, Fitzgerald R, Dietrich W, Czech T, et al. Extracerebral organ dysfunction and neurologic outcome after aneurysmal subarachnoid hemorrhage. Crit Care Med. 1999; 27: 505-514. [CrossRef]
- Hall A, O'Kane R. The extracranial consequences of subarachnoid hemorrhage. World Neurosurg. 2018; 109: 381-392. [CrossRef]
- Song J, Li P, Chaudhary N, Gemmete JJ, Thompson BG, Xi G, et al. Correlating cerebral (18)FDG PET-CT patterns with histological analysis during early brain injury in a rat subarachnoid hemorrhage model. Transl Stroke Res. 2015; 6: 290-295. [CrossRef]
- Kuge Y, Yokota C, Tagaya M, Hasegawa Y, Nishimura A, Kito G, et al. Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke. J Cereb Blood Flow Metab. 2001; 21: 202-210. [CrossRef]
- Heidari P, Esfahani SA, Turker NS, Wong G, Wang TC, Rustgi AK, et al. Imaging of secreted extracellular periostin, an important marker of invasion in the tumor microenvironment in esophageal cancer. J Nucl Med. 2015; 56: 1246-1251. [CrossRef]
- Suzuki H, Nakatsuka Y, Yasuda R, Shiba M, Miura Y, Terashima M, et al. Dose-dependent inhibitory effects of cilostazol on delayed cerebral infarction after aneurysmal subarachnoid hemorrhage. Transl Stroke Res. 2019; 10: 381-388. [CrossRef]
- Nakatsuka Y, Kawakita F, Yasuda R, Umeda Y, Toma N, Sakaida H, et al. Preventive effects of cilostazol against the development of shunt-dependent hydrocephalus after subarachnoid hemorrhage. J Neurosurg. 2017; 127: 319-326. [CrossRef]