OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Free Publication in 2019

Open Access Review

Infectious Considerations for Patients on Immune Checkpoint Inhibitors

Anita Modi, Sherif Beniameen Mossad
Received: July 07, 2019; Published: September 06, 2019; doi:10.21926/obm.transplant.1903085

Abstract: Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of m [...]

Open Access Review

Benefits of Combined Liver Transplant: Protection or Tolerance?

Salim Hamdani, Daniel Azoulay
Received: April 18, 2019; Published: September 04, 2019; doi:10.21926/obm.transplant.1903084

Abstract: The privileged liver by its immunological status is described as a tolerogenic organ. However, these alone do not explain the installation of a tolerance after single or combined liver transplantation (kidney, heart, pancreas, intestine). Other factors appear to be involved in the identification of [...]

Open Access Research Article

Characterization of Early Indicators of Cardiac Allograft Vasculopathy Lesions in a Rat Model Using Non-Invasive Cellular MR

Qing Ye, Yijen L. Wu, Lesley M. Foley, Parker H. Mills, Fang-Cheng Yeh, Haosen Zhang, Danielle F. Eytan, Li Liu, T. Kevin Hitchens, Chien Ho
Received: January 07, 2019; Published: August 29, 2019; doi:10.21926/obm.transplant.1903083

Abstract: Background: Cardiac allograft vasculopathy (CAV) remains a major obstacle to long-term heart allograft survival. A number of studies show that immune mechanisms involved in CAV. Using non-invasive cellular MRI (CMRI) to explore indicators of CAV lesions and characterize its development could provi [...]

Open Access Short Report

Estradiol 17-β Induces Pancreatic Beta-Cell Proliferation through Distinct Estrogen Receptors in a Glucose Dependent Manner

Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Gaby Shefer, Dalia Somjen, Naftali Stern
Received: April 17, 2019; Published: August 27, 2019; doi:10.21926/obm.transplant.1903082

Abstract: Background: Estradiol 17-beta (E2) enhances the function and survival of pancreatic beta-cells but its clinical use has been questioned due to concerns regarding oncogenic potential and feminizing effects in males. The G-protein coupled estrogen receptor (GPER), expressed in pancreatic islets, exhib [...]

Open Access Review

Viral Infections in Allogeneic Hematopoietic Stem Cell Transplant Recipients: Literature Review

Shruthi Kodad, Waleed Sabry, Assem Elsayed, Hadi Goubran, Mohamed Elemary
Received: June 25, 2019; Published: August 26, 2019; doi:10.21926/obm.transplant.1903081

Abstract: Hematopoietic stem cell transplant (HSCT) recipients are at an increased risk of bacterial, viral, fungal and parasitic infections. Past exposures to infections, the degree of immunosuppression, prolonged neutropenia and presence of graft versus host disease (GVHD) are some of the factors which make [...]

Open Access Review

Induction of Tolerance towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models

Scott S. Graves, David W. Mathes, Rainer Storb
Received: November 23, 2018; Published: August 23, 2019; doi:10.21926/obm.transplant.1903080

Abstract: Background: The application of hematopoietic cell transplantation for induction of immune tolerance has been limited by toxicities associated with conditioning regimens and to graft-versus-host disease (GVHD). Decades of animal studies have culminated into sufficient control of these two problems, m [...]

Open Access Original Research

Alemtuzumab Treatment Leads to Delayed Recovery of T Follicular Regulatory Cells, and May Therefore Predispose Patients to de novo Donor-Specific Antibody Formation

Elizabeth F. Wallin, Michelle A. Linterman, Kathryn J. Wood
Received: June 02, 2019; Published: August 19, 2019; doi:10.21926/obm.transplant.1903079

Abstract: Background - T follicular helper (Tfh) and regulatory (Tfr) cells are key players in the formation of long-lived antibody responses. Their circulating counterparts, cTfh and cTfr, are often used as biomarkers because longitudinal sampling of secondary lymphoid tissues is unfeasible in clinical studi [...]

Open Access Research Article

Immunoprotective Encapsulation of Micro-Organs

Assaf Assis, Lena Sapozhnikov, Sandra Camargo, Eduardo Mitrani
Received: May 07, 2019; Published: August 14, 2019; doi:10.21926/obm.transplant.1903078

Abstract: Background: Cell encapsulation technology is most likely the ultimate solution for autologous cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct, is to consider not only the nature of the capsule but also how the cells should be incorporated into [...]

Open Access Original Research

Mortality Risk Factors in Patients who are in Heart Transplantation Waiting List

Petr A. Fedotov, Maria A. Simonenko, Yulia V. Sazonova, Mariya A. Bortsova, Artem N. Kostomarov, Mariya Yu. Sitnikova
Received: February 01, 2019; Published: August 05, 2019; doi:10.21926/obm.transplant.1903077

Abstract: Purpose: to estimate the survival of patients in a heart transplantation waiting list (HTxWL) at V.A.Almazov NMRC from 2010 to 2017 and to define risk factors for death among these patients. Materials and methods: A single-centre retrospective study of 151 patients with advanced chronic heart failur [...]

Open Access Research Article

Never Say Never: Unexpected Pulmonary Pathogens Found on Autopsy in Hematopoietic Cell Transplantation Recipients

Ashrit Multani, Libby S. Allard, Joanna K. Nelson
Received: June 03, 2019; Published: July 29, 2019; doi:10.21926/obm.transplant.1903076

Abstract: Hematopoietic cell transplantation is frequently complicated by infectious disease-related complications, especially pneumonia. Candida and enterococci are often overlooked as pulmonary pathogens with some clinicians firmly believing that these organisms never cause pneumonia. Here, we present a ser [...]

Open Access Review

Endemic Mycoses and Cryptococcus in Solid Organ Transplant Recipients

Omer Eugene Beaird, Deepa Nanayakkara, Pryce Gaynor, Joanna Schaenman
Received: April 05, 2019; Published: July 26, 2019; doi:10.21926/obm.transplant.1903075

Abstract: The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for a dimorphic life cycle, a specific geographic distribution, and typical infection via environmental exposure. Their nonspecific presentation, often mimicking othe [...]

Open Access Review

Our Steps toward Subcutaneous Transplantation of Macro-Encapsulated Islets

Shoichiro Sumi, Sin-Yu Yang, Priyadarshini Canning, Kai-Chiang Yang
Received: May 29, 2019; Published: July 24, 2019; doi:10.21926/obm.transplant.1903074

Abstract: Background: Diabetes mellitus (DM) can be cured or greatly ameliorated by adequate insulin secretion from a relatively small volume of insulin-producing cells. Cell encapsulation enables allo- and even xeno-geneic cell therapy without immunosuppression. However, micro-encapsulated islets used in rec [...]

Open Access Review

Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Melissa Mortensen, Christine Lundberg, Simon Horslen
Received: December 05, 2018; Published: July 17, 2019; doi:10.21926/obm.transplant.1903073

Abstract: Background: Infants and children undergoing liver transplant require ongoing nutritional evaluation throughout the pre and post-transplant period. The pathophysiologic causes of chronic liver disease and acute liver failure are varied, and each present different and unique nutritional challenges. Me [...]

Open Access Review

Single Cell Transcriptomic Analysis of Pancreatic β Cell Development and Differentiation from Pluripotent Stem Cells

Chunhui Xie, Lillian Ye, Yeh-Chuin Poh, George Harb
Received: May 06, 2019; Published: July 17, 2019; doi:10.21926/obm.transplant.1903072

Abstract: Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represen [...]

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Ibrahim Fathi, Takehiro Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi, Akiko Inagaki, Makiko Kikkawa, Fumiko Ono, Hiroo Iwata, Yohichi Yasunami, Masafumi Goto
Received: March 27, 2019; Published: July 09, 2019; doi:10.21926/obm.transplant.1903071

Abstract: BACKGROUND. Current non-human primate diabetic models, namely those induced by total pancreatectomy or streptozotocin (STZ) injection, suffer from several disadvantages, including a long surgical procedure, the need for continual digestive enzyme replacement, and a delayed oral intake after total pa [...]

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Abstract: In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the on [...]

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active Glp-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Abstract: Background One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality  cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have [...]

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Abstract: The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understand [...]

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Abstract: Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for tra [...]

Open Access Original Research

Liver Transplantation or Resection for Treatment of Hepatocellular Carcinoma in Patients with Well-Compensated Cirrhosis: A Decision Analysis Model

Amanda B. Cooper, Stephen M. Downs, Nicholas J Skill, Richard S. Mangus, Chandrashekhar A. Kubal, Mary A. Maluccio
Received: March 18, 2019; Published: May 13, 2019; doi:10.21926/obm.transplant.1902063

Abstract: Hepatocellular carcinoma (HCC) is a lethal tumor, for which liver resection and transplantation are the only potentially curative treatments. No prospective, randomized study has compared survival in patients with compensated cirrhosis after the two operations. Decision analysis modeling is an objec [...]

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062

Abstract: Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe [...]

Open Access Review

Update in the Use of Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy After Heart Transplantation

Richard Cheng, Jon Kobashigawa
Received: January 23, 2019; Published: April 09, 2019; doi:10.21926/obm.transplant.1902061

Abstract: Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generat [...]

OBM Transplantation welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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