OBM Transplantation

(ISSN 2577-5820)

OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.

OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.

We welcome original clinical studies as well as basic science, reviews, short reports/rapid communications, case reports, opinions, technical notes, book reviews as well as letters to the editor. 

Free Publication in 2019

Open Access Research Article

A Simple and Effective Non-Human Primate Diabetic Model Combining Sub-Total Pancreatectomy and Low-Dose Streptozotocin Injection

Ibrahim Fathi, Takehiro Imura, Kozue Imura, Megumi Goto, Yasuhiro Igarashi, Akiko Inagaki, Makiko Kikkawa, Fumiko Ono, Hiroo Iwata, Yohichi Yasunami, Masafumi Goto
Received: March 27, 2019; Published: July 09, 2019; doi:10.21926/obm.transplant.1903071

Abstract: BACKGROUND. Current non-human primate diabetic models, namely those induced by total pancreatectomy or streptozotocin (STZ) injection, suffer from several disadvantages, including a long surgical procedure, the need for continual digestive enzyme replacement, and a delayed oral intake after total pa [...]

Open Access Review

Clinical Tolerance Trials in Renal Transplantation – Where Do We Stand?

Joachim Andrassy, Antje Habicht
Received: November 05, 2018; Published: June 27, 2019; doi:10.21926/obm.transplant.1902070

Abstract: In recent years, the potential of hematopoietic stem cells, regulatory T-cells and mesenchymal stem cells resulted in a variety of clinical tolerance trials. Every approach has yielded promising results. However, the riddle of transplant tolerance has not been solved as of yet. The results of the on [...]

Open Access Research Article

The DPP4 Inhibitor Sitagliptin Increases Active Glp-1 Levels from Human Islets and May Increase Islet Cell Survival Prior to Transplantation

Scott A. Campbell, Matthew Hubert, Janyne Johnson, Nicole Salamon, Peter E. Light
Received: March 12, 2019; Published: June 26, 2019; doi:10.21926/obm.transplant.1902069

Abstract: Background One of the goals of clinical islet transplantation is to achieve a single-donor transplant that is dependent on obtaining enough quality  cell mass from one donor pancreas. Human islets are routinely cultured prior to transplantation, and pro-survival factors such as GLP-1 analogues have [...]

Open Access Review

Human Islet Isolation and Distribution Efforts for Clinical and Basic Research

Natasha Hui Jin Ng, Wei Xuan Tan, Ye Xin Koh, Adrian Kee Keong Teo
Received: March 11, 2019; Published: June 21, 2019; doi:10.21926/obm.transplant.1902068

Abstract: The ability to obtain purified human islets routinely and reproducibly has enabled substantial progress in providing a safe and reliable treatment option for adult Type 1 diabetes patients. The availability of human islets for basic research has also significantly impacted the progress of understand [...]

Open Access Original Research

Ex-Vivo Perfusion of Donor Hearts: The Feasibility of Banked Blood for Normothermic Machine Perfusion

Hong Chee Chew, Ling Gao, Jeanette E. Villaneuva, Aoife Doyle, Mark Hicks, Andrew Jabbour, Kumud K. Dhital, Peter S. Macdonald
Received: March 09, 2019; Published: June 18, 2019; doi:10.21926/obm.transplant.1902067

Abstract: Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in [...]

Open Access Review

Non-CMV Viral Infections Following Solid-Organ Transplantation – Focus on Human T-Cell Lymphotropic Virus Type-1 and Human Herpesviruses-6,-7 and -8

Katerina G. Oikonomou, Sarah Taimur
Received: February 14, 2019; Published: June 17, 2019; doi:10.21926/obm.transplant.1902066

Abstract: In non-endemic areas, HTLV-1 is an uncommon pathogen in the transplant host but can be associated with significant morbidity and mortality. Careful assessment of risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timel [...]

Open Access Review

Respiratory Viral Infections in Lung Transplant Recipients: Implications for Long Term Outcomes and Emerging Therapies

Sheila Krishnan, Chadi Hage, Raymond Coakley, David van Duin, Leonard Jason Lobo
Received: February 18, 2019; Published: June 10, 2019; doi:10.21926/obm.transplant.1902065

Abstract: Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infectio [...]

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Gopalakrishnan Loganathan, Michael G. Hughes, Gregory L. Szot, Kate E. Smith, Abid Hussain, Daniel R. Collins, Michael L. Green, Francis E. Dwulet, Stuart K. Williams, Klearchos K. Papas, Robert C. McCarthy, Appakalai N. Balamurugan
Received: March 29, 2019; Published: May 24, 2019; doi:10.21926/obm.transplant.1902064

Abstract: Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for tra [...]

Open Access Original Research

Liver Transplantation or Resection for Treatment of Hepatocellular Carcinoma in Patients with Well-Compensated Cirrhosis: A Decision Analysis Model

Amanda B. Cooper, Stephen M. Downs, Nicholas J Skill, Richard S. Mangus, Chandrashekhar A. Kubal, Mary A. Maluccio
Received: March 18, 2019; Published: May 13, 2019; doi:10.21926/obm.transplant.1902063

Abstract: Hepatocellular carcinoma (HCC) is a lethal tumor, for which liver resection and transplantation are the only potentially curative treatments. No prospective, randomized study has compared survival in patients with compensated cirrhosis after the two operations. Decision analysis modeling is an objec [...]

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Gianluca Donatini, Sébastien Giraud, Jean-Louis Kraimps, Jérôme Danion, Thierry Hauet
Received: April 08, 2019; Published: April 15, 2019; doi:10.21926/obm.transplant.1902062

Abstract: Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe [...]

Open Access Review

Update in the Use of Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy After Heart Transplantation

Richard Cheng, Jon Kobashigawa
Received: January 23, 2019; Published: April 09, 2019; doi:10.21926/obm.transplant.1902061

Abstract: Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generat [...]

Open Access Review

Right Heart Failure in Left Ventricular Assist Device Patients

James Farag, Silvana Marasco
Received: February 13, 2019; Published: April 08, 2019; doi:10.21926/obm.transplant.1902060

Abstract: Left ventricular assist devices (LVADs) improve quality of life in end-stage heart failure patients but a frequent complication is Right heart failure (RHF) causing significant morbidity and mortality. This review article discusses key issues that need to be considered in the assessment and clinical [...]

Open Access Review

Islet Autotransplantations for Total Pancreatectomy

Naoaki Sakata, Gumpei Yoshimatsu, Shohta Kodama  
Received: January 15, 2019; Published: April 03, 2019; doi:10.21926/obm.transplant.1902059

Abstract: Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease like chronic pancreatitis or pancreatic injury. However, it always abolishes the pancreatic exo- and endocrine functions and the nutritional condition of the patients is significantly impaired. [...]

Open Access Case Report

Secondary Antibody Deficiency in a Heart Recipient with Systemic Aspergillosis

Javier Carbone, Juan Fernandez-Yañez, Iago Sousa, Patricia Muñoz, Elizabeth Sarmiento
Received: November 23, 2018; Published: March 22, 2019; doi:10.21926/obm.transplant.1901058

Abstract: Secondary antibody deficiency has been associated with risk of invasive fungal infections in solid organ transplantation. Single center, multicenter and metanalysis studies have tested this association. Therapy of these infectious complications in the presence of a secondary antibody deficiency afte [...]

Open Access Case Report

Prolonged and Resistant Cutaneous Infection in Newly Transplanted Renal Patient

Sofia Oliveira Correia, Catarina Eusébio, Ana Sofia Cipriano, Virgínia Lopes, Ramon Vizcaíno, António Cabrita, Manuela Almeida, Sofia Pedroso, Leonidio Dias, La Salete Martins, António Castro Henriques
Received: October 18, 2018; Published: March 07, 2019; doi:10.21926/obm.transplant.1901057

Abstract: We present a case of a renal transplant patient with surgical wound infection 20 1days after kidney transplant.

Open Access Research Article

The Contribution of Psychotherapists to Patient Care in Multidisciplinary Heart Transplantation Care Teams

Katharina Tigges-Limmer, Stephan Ensminger, Yvonne Brocks, Scott Stock Gissendanner, Jan Gummert
Received: October 28, 2018; Published: March 05, 2019; doi:10.21926/obm.transplant.1901056

Abstract: Background: The participation of mental health professionals in multidisciplinary care teams for heart transplantation has advanced to international standard practice. The contribution of mental health interventions to patient outcomes in this setting have not been the subject of systematic study. [...]

Open Access Review

Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function

Christine A. Beamish, Omaima M. Sabek
Received: November 08, 2018; Published: March 05, 2019; doi:10.21926/obm.transplant.1901055

Abstract: Islet transplantation is a promising technique for millions of patients with diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of the [...]

Open Access Review

Role of Procalcitonin in Management of Infection in Solid Organ Transplantation Recipients: Review

Dagan Coppock, Caytlin Deering, Shara Epstein, Dong Heun Lee
Received: December 23, 2018; Published: March 01, 2019; doi:10.21926/obm.transplant.1901054

Abstract: Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation [...]

Open Access Case Report

Candida auris and Heart Transplantation. Preoperative Attitude.

Raquel López-Vilella, Alba Cecilia Ruiz-Gaitán, José Ricardo Gimeno Costa, Elena Marqués-Sulé, Rosario Vicente Guillén, Javier Pemán García, Ignacio Sánchez-Lázaro, Luis Almenar Bonet
Received: October 15, 2018; Published: February 27, 2019; doi:10.21926/obm.transplant.1901053

Abstract: In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multi-resistant yeast that is associated with serious infections and with mortality rates as high as 70% with a mortality rate that can reach 70%. This problem is especially serious in patients who [...]

Open Access Review

Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases

David W. Scharp, Jayagowri Arulmoli, Kelly Morgan, Hannah Sunshine, Ergeng Hao
Received: October 15, 2018; Published: February 26, 2019; doi:10.21926/obm.transplant.1901052

Abstract: Background This presentation of a six-year study processing human islets for research and transplantation includes a review of multi-center transplant studies identifying key variables critical for successful islet processing and defines standardized processing procedures required to provide highly [...]

Open Access Research Article

Aspiration of Gastrointestinal Material and Induction of Fibronectin Expression in Lung Transplant Recipients: Implications for Early Airway Remodeling

Jill Gualdoni, Jeff Ritzenthaler, Ibrahim Elkhawas, Gerene Bauldoff, David Nunley, Jesse Roman
Received: November 29, 2018; Published: February 20, 2019; doi:10.21926/obm.transplant.1901051

Abstract: Background: Gastroesophageal reflux disease has been associated with allograft dysfunction in lung transplant (LTX) recipients. While the mechanisms are unclear it is postulated that microaspiration of gastrointestinal material (GIM) leads to inflammation and airway remodeling that culminates in ob [...]

Open Access Review

New Frontiers in Solid Organ Transplantation from Donors with Human Immunodeficiency Virus, Hepatitis C Virus Infection, and Multidrug Resistant Organisms

Jessica Lum, Sherif B. Mossad
Received: October 26, 2018; Published: February 14, 2019; doi:10.21926/obm.transplant.1901050

Abstract: Despite the advances that have been made in the field of solid organ transplantation (SOT), organ shortage remains a persistent problem and continues to worsen. In addition, the donor pool has been changing with the increase in drug overdose deaths each year with the ongoing opioid epidemic More d [...]

Open Access Editorial

Sex and Gender Issues in Heart Transplantation

Maria Simonenko, Petr Fedotov
Received: February 01, 2019; Published: February 13, 2019; doi:10.21926/obm.transplant.1901049

Abstract: Sex and gender issues in heart transplantation

Open Access Review

Tuberculosis Screening and Treatment in Solid Organ Transplantation

David J. Epstein, Aruna K. Subramanian
Received: November 18, 2018; Published: February 12, 2019; doi:10.21926/obm.transplant.1901048

Abstract: Background: Tuberculosis (TB) is a common infection with challenges in diagnosis and treatment. Management of TB in solid organ transplant (SOT) candidates and recipients poses unique challenges not seen in other populations. Questions and recommendations: Latent TB infection (LTBI) is important to [...]

Open Access Review

Challenges in Diagnosis and Management of Nontuberculous Mycobacteria in Solid Organ Transplantation

Joanna K. Nelson, Aruna Subramanian
Received: November 30, 2018; Published: February 01, 2019; doi:10.21926/obm.transplant.1901047

Abstract: Non-tuberculous mycobacteria (NTM) infections are relatively rare but carry significant morbidity in solid organ transplant (SOT) recipients. Given the rarity of disease and diagnostic limitations, a high index of suspicion is required for accurate diagnosis and initiation of appropriate treatment. [...]

OBM Transplantation welcomes the following types of articles: original research, review, communication, opinion, case report, comment, conference report, technical note, book review, etc. There is no restriction on the length of the papers, color figures, supplementary file types. More details please see Instructions for Authors.

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