Open Access Review

Lignocellulosic Biomass and Enzymes: Fundamentals, Emerging Technologies, and Applications

Received: 25 January 2025;  Published: 19 June 2025;  doi: 10.21926/cr.2502004

Abstract

Lignocelluloses are complex plant polysaccharides made of lignin, cellulose, and hemicellulose, and products made from these components find immense market potential. They can be effectively valorized to products related to bioenergy, bioplastics, food and nutrition, medication delivery systems, and other elements. Significant sources of lignocellulosic [...]

Open Access Case Report

Checkpoint Inhibition Followed by CAR-T Cell Therapy in Refractory PMLBCL: Immunologic Response and Fertility Preservation in a Young Patient

Received: 22 February 2025;  Published: 18 June 2025;  doi: 10.21926/obm.transplant.2502253

Abstract

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive B-cell malignancy that may exhibit resistance to standard chemoimmunotherapy. Novel immunotherapeutic strategies, including checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy, are being explored in cases that are refractory to treatment. We report the case of [...]

Open Access Review

Physicality of Spirituality: The Interplay of the Autonomic Nervous System, Prefrontal Cortex, and Spiritual Life in Light of Galatians 5:16-25

Received: 04 March 2025;  Published: 18 June 2025;  doi: 10.21926/obm.icm.2502025

Abstract

This article examines the complex relationship between the autonomic nervous system, the prefrontal cortex, and spiritual life, providing an interdisciplinary analysis in light of Galatians 5:16-25. Through a combination of theological reflection and insights from neuroscience, it explores how spiritual practices, such as meditation and prayer, influenc [...]

Open Access Editorial

In the Mirror of the Past, in the Light of the Future: The ISLA – A President Looks Back and Forward

Received: 15 June 2025;  Published: 18 June 2025;  doi: 10.21926/obm.icm.2502024

Abstract

This editorial for the 27th ISLA Congress in Beverungen in Germany reflects on the development, achievements, and challenges of the International Society for Medical Laser Applications (ISLA-transcontinental) from the perspective of its President for Science and Research, Univ.-Prof. DDr. Gerhard Litscher. It reviews the organization’s milestones [...]

Open Access Original Research

Modern UNOS Data Reveals Septuagenarians Have Inferior Heart Transplant Survival

Received: 10 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.transplant.2502252

Abstract

While heart transplantation is increasingly performed in the United States for elderly patients, survival outcomes have primarily been analyzed in single-center studies. The few existing long-term studies have indicated no difference in HTx outcomes between patients ≥70 years and 60-69 years age, but these studies only assessed to 5-years post-transpl [...]

Open Access Original Research

Dependence Levels and Oral Functionality in Older People

Received: 03 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.geriatr.2502316

Abstract

It has been suggested that an individual's overall functional capacity gradually declines with age. It has been reported that a decline in oral functionality increases the risk of sarcopenia and frailty, which contributes to the decrease in functional capacity. In Chile, the Preventive Medical Examination for Older Adults (EMPAM) is used to assess the [...]

Open Access Review

Chemical Neuroscience of Heterocyclic N-Amines: Implications for Pain Management, Mental Health, and Opioid Withdrawal

Received: 05 December 2024;  Published: 10 June 2025;  doi: 10.21926/obm.neurobiol.2502289

Abstract

This study reviews the biochemical mechanisms and clinical implications of N-heterocyclic amine drugs, particularly in the context of pain management, mental health, and opioid withdrawal. It highlights the structural diversity and receptor binding capabilities of these compounds, which enable them to target the nervous system and cross the blood-brain [...]

Open Access Original Research

Reciprocal Translocations in Prenatal Diagnosis: Latin America Data

by Luis A. Méndez-Rosado  , Luis A. Sotillo-Bent  , José Sotillo-Lindo  , Anduriña Barrios-Martínez  , Dulce Hechavarria-Estenoz  , Margarita Mayeta  , Jose Hernández-Gil  , Hector Pimentel-Benitez  , Maria Elena de la Torre  , Hibo Moreno  , Pedro Díaz-Véliz  , Alicia Vaglio  , Roberto Quadrelli  , Diana Sánchez-Peñarate  , Mabel Cerrillo-Hinojosa  , Pedro Carbonell-de la Torre  , Judith Pupo-Balboa  , Michel Soriano-Torres  , Marilyn del Sol  , Arlay Castelvi  , Enny Morales  , Damarys García  , Rocío Serrano-Hidalgo  , Catalina Obando  , Liz Pardo  , Laritza del Toro  , Miladys Martinez  , Conrado Uria-Gómez  , Maria G Arteaga Ontiveros  , Mayte Castro  , Odalys Rabelo  , Sahily Miñoso  , Deysi Licourt  , Irenia Blanco  , Roberto Lardoeyt-Ferrer  , Nereida Gonzalez  and Olga Quiñones-Masa
Received: 24 November 2024;  Published: 10 June 2025;  doi: 10.21926/obm.genet.2502296

Abstract

Generally, in reciprocal translocations there are no gains or losses of genetic material. From the clinical point of view, its primary importance lies in the fact that it can generate errors due to incorrect chromosome segregation during meiosis in carriers. On the other hand, other mutations are less frequent in the genome, specifically in the DNA [...]

Open Access Review

Integrating RNA-Seq Biomarkers and Diagnostic Algorithms to Improve Liver Transplant Outcomes: A Comprehensive Review

Received: 21 February 2025;  Published: 09 June 2025;  doi: 10.21926/obm.transplant.2502251

Abstract

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as liver biopsies and liver function tests (LFTs), often [...]

Open Access Original Research

The Effect of the Levonorgestrel-Releasing Intrauterine Device on Hypoactive Sexual Desire Disorder in Women

Received: 28 December 2024;  Published: 06 June 2025;  doi: 10.21926/obm.icm.2502023

Abstract

This research focused on the evaluation of the relationship between the levonorgestrel-releasing intrauterine device and Hypoactive Sexual Desire Disorder in women. Sexual desire disorder is part of a group of sexual dysfunctions. A group of 60 women with a diagnosis of hypoactive sexual desire were tested in the period from July 2023 to July 2024 at [...]

Open Access Review

Mechanisms of Action of Ready-to-Use Therapies in Hematologic Malignancies: From Clinical Impact to Future Directions

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Abstract

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection [...]

Open Access Research Article

Physicochemical Characterization of Fresh and Powdered Tomato in Arba Minch, Ethiopia

Received: 07 January 2025;  Published: 02 June 2025;  doi: 10.21926/rpn.2502013

Abstract

Tomato (Solanum lycopersicum L.) is the largest vegetable crop produced and consumed in the world. Tomatoes are a top source of Vitamin A and C, contain more dietary fibre, beta-carotene, iron, lycopene, magnesium, niacin, potassium, phosphorus, riboflavin, and thiamine. Tomatoes have a limited shelf life in ambient conditions and are highly perishable [...]

Open Access Review

Locked Plating Versus Retrograde Intramedullary Nailing in The Surgical Fixation of Periprosthetic Supra-condylar Knee Fractures: An Updated Systematic and Meta-Analysis Review

Received: 25 November 2024;  Published: 02 June 2025;  doi: 10.21926/obm.geriatr.2502315

Abstract

Meta-analysist to evaluate impact of Surgical Methods on Outcomes in periprosthetic supracondylar knee fracture management. This study examines the rate of functional outcomes and complications associated with two distinct surgical methods for the management of periprosthetic supracondylar knee fractures in patients treated with Low Contact Locking [...]

Open Access Review

Overview of Practical Applications of Healthcare Ethics for Older Adults

Received: 30 January 2025;  Published: 30 May 2025;  doi: 10.21926/obm.geriatr.2502314

Abstract

Identifying and addressing ethical issues in the care of older adults can be complex and challenging in clinical settings. This article reviews specific ethical principles including autonomy, beneficence, non-maleficence, dignity, and justice, and explores them in the context of interprofessional geriatric care. Situations and related ethical components [...]

Open Access Case Report

An Unusual Presentation of Pleural Effusion in an Elderly Woman Post-COVID-19 Infection: A Case Report

Received: 18 February 2025;  Published: 29 May 2025;  doi: 10.21926/obm.geriatr.2502313

Abstract

Pleural effusions are defined as accumulations of fluid in the pleural cavity surrounding the lungs. They are often secondary outcomes of underlying conditions, such as congestive heart failure, malignancy, or pneumonia. Acute cases of COVID-19 pneumonia have been linked to episodes of pleural effusion, but these cases are often rare. In this report [...]

Open Access Case Report

Best Care for the Dying, Right Plan at the Right Time: A Case Report

Received: 31 January 2025;  Published: 28 May 2025;  doi: 10.21926/obm.geriatr.2502312

Abstract

The growing number of individuals with palliative care needs has led to an increased demand for specialized palliative care teams.. However, these teams often struggle to meet the demand, requiring all nurses to recognize and provide appropriate care during a patient’s last hours and days of life (LHDL). This case report aims to highlight the importan [...]

Open Access Research Article

Development of Parametric Voronoi-Based Scaffolds for Trabecular Bone Tissue Replacement Using Additive Manufacturing

Received: 07 February 2025;  Published: 28 May 2025;  doi: 10.21926/rpm.2502010

Abstract

Tissue engineering is a technique for regenerating living tissue using portions of the patient's tissue, which are dissociated into cells and cultured on biological or synthetic supports before being transferred to the patient. In this context, the present study seeks to develop implant models (scaffolds) for replacing trabecular bone tissue, with requi [...]

Open Access Review

Emerging Progress in Nanotechnological Influence on Polymeric Textile Finishing

Received: 13 January 2025;  Published: 27 May 2025;  doi: 10.21926/rpm.2502009

Abstract

Nanotechnology has revolutionized the textile industry by introducing innovative finishing techniques that enhance the durability and performance of textile materials and the application of nanoscale/nanoparticles/nanomaterials and processes to improve the properties and performance of textiles. The synergism of textile technology and nanotechnological [...]

Open Access Original Research

The Relationship between Anger, Stress, Psychological Distress and Mood Disorders among Entrepreneurs

Received: 18 December 2024;  Published: 26 May 2025;  doi: 10.21926/obm.neurobiol.2502288

Abstract

The present study investigates the association between anger, stress, psychological distress and mood disorders among Egyptian entrepreneurs. Approach-wise, the study is quantitative, and its cross-sectional data were collected using a questionnaire. The study’s respondents are Egyptian entrepreneurs involved in several business activities. Hence [...]

Open Access Original Research

In Silico Evaluation of Anti-SARS-CoV-2 Bioactive Compounds from Jatropha curcas

Received: 12 March 2025;  Published: 25 May 2025;  doi: 10.21926/obm.genet.2502295

Abstract

Jatropha curcas L., a medicinal shrub renowned for its diverse phytochemicals, has been traditionally used to treat various ailments, including ulcers, neoplasms, and dermatological conditions. Despite its pharmacological promise, its potential against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) remains unexplored. This study investigat [...]

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