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Table of Content

Open Access Concept Paper

Biological Age versus Chronological Age in the Prevention of Age Associated Diseases

Received: 31 January 2019;  Published: 05 May 2019;  doi: 10.21926/obm.geriatr.1902051

Abstract

Aging is associated with an increased incidence of major diseases, including cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome, quality of life and are commonly applied as age-dependent indications based on evidence of efficacy for specific groups of the aging population. They likely contribute to the observed increase in life expectancy through the reduction of incidence and the retarda [...]

2773 18301

Open Access Review

FISHing for Unstable Cellular Genomes in the Human Brain

Received: 06 February 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902076

Abstract

The human brain has been repeatedly shown to exhibit intercellular/somatic genomic variations at the chromosomal level, which are involved in the neuronal diversity in health and disease. Brain-specific chromosomal mosaicism (aneuploidy) and chromosome instability play a role in the normal and pathological neurodevelopment, neurodegeneration and aging of the central nervous system. Regardless of achievements in somatic cell (single-cell) genomics, there is still no consensus on the amounts of chromosomally abnormal [...]

1900 9461

Open Access Opinion

The Link(s) between Compassion and Healing

Received: 30 January 2019;  Published: 30 April 2019;  doi: 10.21926/obm.icm.1902030

Abstract

While it may seem intuitive to suggest that compassion aids in the healing process, there is actual evidence to support that compassion changes physiology, which in turns affects emotional and physical healing. The focus of this opinion paper is on the use of compassion between health care providers and patients based on the use of compassion in the mental health field. Not only do patients benefit from compassion, but health care providers may also benefit. Creating compassionate relationships with patients may [...]

1747 7609

Open Access Editorial

Epigenetics is Here to Stay

Received: 24 April 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902075

Abstract

none

1580 8167

Open Access Review

Disturbed Ovarian Differentiation in XX;SRY-Negative Dogs

Received: 30 December 2018;  Published: 29 April 2019;  doi: 10.21926/obm.genet.1902074

Abstract

In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the g [...]

2153 14355

Open Access Research Article

Lifestyles and Complementary Medicine: A Survey in the Region of Tuscany

Received: 27 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902029

Abstract

Background: According to the international literature, users of Complementary Medicine (CM), Complementary and Alternative Medicine (CAM) and Complementary and Integrative Medicine (CIM) are physically more active, less overweight and have healthier lifestyles than the average Tuscan population. Aim: To evaluate the socio-demographic characteristics and lifestyles of patients of CM public clinics in the region of Tuscany and to define their profiles in terms of physical exercise, smoking habits, diet, intake of alc [...]

2223 11347

Open Access Original Research

Observational Study on Auriculotherapy in the Treatment of Chronic Musculoskeletal Pain: Preliminary Data

Received: 26 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902028

Abstract

Introduction: Pain in musculoskeletal disorders is a common problem that involves high social and individual costs. Systematic reviews and randomized controlled trials show that a number of treatments usually applied in this field are not effective. On the other hand, there is clinical evidence of the effectiveness of physical exercise, acupuncture, and auriculotherapy. Side effects of current medication limit their use. Aim: To evaluate the effectiveness of auriculotherapy on the pain of patients suffering from ch [...]

2432 18145

Open Access Opinion

Valued Applications of Lignin Nanoparticles

Received: 08 March 2019;  Published: 26 April 2019;  doi: 10.21926/rpm.1902001

Abstract

Technical lignins from the biorefinery, pulp, and paper industries are largely underutilized, even though this aromatic and randomly structured biopolymer could be an interesting raw material for advanced applications in addition to bulk daily goods. Recently, colloidal lignin particles (CLPs) have gained much of the research interests due to the attractive multi-functional properties of the biopolymer. Utilization of lignin in nanoparticulate morphology resolves most of the drawbacks when using lignin (heterogenei [...]

2929 17852

Open Access Project Report

An Evaluation of a Community-Based Psychoeducation Program for Successful Ageing

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

Abstract

Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their outcomes is essential. This study used mixed methods to evaluate cognitive and behavioural changes and to monitor psychological health and active ageing in participants of a longstanding positive ageing psycho [...]

1768 12161

Open Access Review

The Rational Use of Diuretics in the Management of Cirrhotic Ascites in Japan

Received: 04 February 2019;  Published: 25 April 2019;  doi: 10.21926/obm.hg.1902018

Abstract

In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body fluid volume in liver cirrhosis, and aldosterone antagonists and loop diuretics have been widely used until now. In Japan, tolvaptan, a vasopressin V2 receptor antagonists, became available in September 2013, expanding trea [...]

1539 15489

Open Access Review

Integrative Cancer Therapy with Special Focus on Add-On Homeopathy: The Experience at Lienz Hospital

Received: 02 March 2018;  Published: 25 April 2019;  doi: 10.21926/obm.icm.1902027

Abstract

The first part of this position paper focuses on the debate about the scientific status of homeopathy and presents some answers. The scientific debate however, does not represent the available scientific evidence, which actually supports our limited data. Thus, it seems important and we aim to present how homeopathy can be part of an integrated concept in cancer care and how this is approved by randomized controlled trials. We present some arguments which were helpful to us in the discussion with oncologists that d [...]

2111 9134

Open Access Review

The Role of Self-Compassion in Recovery from Substance Use Disorders

Received: 04 March 2019;  Published: 24 April 2019;  doi: 10.21926/obm.icm.1902026

Abstract

Background: A large body of empirical evidence has supported the notion that individuals with substance use disorders (SUDs) have difficulty regulating their negative emotions and employing emotion-regulation strategies. The aim of this article is to (a) explore the role of self-compassion in providing an emotion-regulation strategy for initiating a process of recovery from SUDs; (b) examine the role of self-compassion in building recovery capital (RC) to promote long-term recovery; and (c) examine the practice of [...]

5195 29894

Open Access Case Report

Daily Observations of Preserved Cognition and Quality of Life after Multiple Therapies for Postmortem-Verified Severe Alzheimer’s

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Abstract

Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows significant preservation of cognition and quality of life in the daily routine of a woman with severe Alzheimer’s who was given multiple therapeutic interventions. Alzheimer’s disease involves multiple d [...]

1543 9863

Open Access Original Research

Moderators of Treatment Outcomes from Family Caregiver Skills Training: Secondary Analysis of a Randomized Controlled Trial

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Abstract

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

2098 11484

Open Access Opinion

Compassion in Medicine – A Psychiatric Physician’s View

Received: 14 March 2019;  Published: 18 April 2019;  doi: 10.21926/obm.icm.1902025

Abstract

There are several definitions of sympathy, empathy, and compassion on the internet. I have chosen the above definitions to emphasize their salient differences, for the following reason: In medical school, in the early 1960s, we were taught not to sympathize with patients, but to empathize: By empathizing, one can retain some professional objectivity toward the patient, in order to be of some help. To sympathize, on the other hand, was to immerse oneself in the patient’s suffering and lose one’s professional per [...]

1722 8417

Open Access Case Report

Fluorescence in Situ Hybridisation (FISH) is the First Tool to Identify Hypodiploidy in Paediatric Acute Lymphoblastic Leukaemia

Received: 24 December 2018;  Published: 17 April 2019;  doi: 10.21926/obm.genet.1902073

Abstract

Hypodiploidy has a low incidence in childhood acute lymphoblastic leukaemia (ALL). Patients are usually stratified into three subgroups, to allocate the correct treatment according to their ploidy level: high hypodiploidy (40-45 chromosomes), low hypodiploidy (33-39 chromosomes) and near haploidy (23-29 chromosomes). In this paper, a case is presented of near-haploid childhood ALL where fluorescence in situ hybridisation (FISH) provided an insight into the near-haploidy chromosomal aberration initially missed on ro [...]

1916 13194

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

Abstract

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

1893 11798

Open Access Research Article

Integrated Medicine Strongly Improves Post-Stroke Rehabilitative Performance in a Public Health Facility in Italy

Received: 30 September 2018;  Published: 17 April 2019;  doi: 10.21926/obm.icm.1902024

Abstract

Since 2011, the Tuscany Regional Authority has been funding the use of Integrated Medicine (IM) in a clinical setting in Pitigliano Hospital, with the aim of testing the true efficacy of complementary and alternative medicine (CAM) in a hospital setting. The clinical setting also comprises the Manciano rehabilitation facility whose services include post-stroke rehabilitation. This study aims to establish if IM helps to improve the rehabilitation performance of stroke patients. The study compared 212 patients divide [...]

2024 17920

Open Access Case Report

Unexpected Long Survival of a Patient with Polycythemia Vera

Received: 16 January 2019;  Published: 16 April 2019;  doi: 10.21926/obm.icm.1902023

Abstract

This case reports of a 71-year-old patient with polycythemia vera (PCV). Homeopathic treatment began 15 years after his diagnosis at the age of 51. The frequency of phlebotomies was lowered significantly after the start of the homeopathic treatment; the patient survived another 16 years without chemotherapy, which he had rejected despite appropriate education. For someone with PCV who denied chemotherapy, this patient had a long survival time of more than 30 years, essentially enjoying good health and high quality [...]

2286 33789

Open Access Editorial

Pancreatic Islet Transplantation: State of the Art and Future Perspectives

Received: 08 April 2019;  Published: 15 April 2019;  doi: 10.21926/obm.transplant.1902062

Abstract

Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe hypoglycaemia events and impaired awareness of hypoglycaemia. Recent trials had demonstrated islet transplantation to be more effective than current medical treatment and improvements in outcomes also have been reported [...]

1743 8818

Open Access Review

Walled-Off Necrosis in Acute Pancreatitis: Clinical and Therapeutic Implications

Received: 07 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.hg.1902017

Abstract

Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic necrosis is a new entity of complications of acute pancreatitis. It is defined as a mature, encapsulated collection of pancreatic and/or peripancreatic necrosis which has developed a well-defined inflammatory wall. WON us [...]

1461 9200

Open Access Communication

The Process of Integration of Complementary Medicines in Public Healthcare Service of Tuscany (Italy)

Received: 22 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.icm.1902022

Abstract

Complementary Medicine (CM) is being increasingly used by European citizens in order to increase their overall state of health and well-being, as well as to treat various illnesses and diseases. The interest for these therapies has progressively risen also in Italy and in Tuscany as well. In response to the increasing demand in the past few years by the Tuscan citizens, the region of Tuscany has started their integration in the healthcare service. Since 1996, the Tuscan Regional Healthcare Plans (RHPs) have been co [...]

2244 14116

Open Access Review

Update in the Use of Percutaneous Coronary Intervention for Cardiac Allograft Vasculopathy After Heart Transplantation

Received: 23 January 2019;  Published: 09 April 2019;  doi: 10.21926/obm.transplant.1902061

Abstract

Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generation drug-eluting stents has been associated with high and unacceptable restenosis rates. However, second-generation drug-eluting stents are associated with favorable stent and lesion patency. Stent and lesion patency now [...]

1509 9132

Open Access Review

RNA Editors and DNA Mutators: Cancer Heterogeneity Through Sequence Diversification

Received: 03 December 2018;  Published: 08 April 2019;  doi: 10.21926/obm.genet.1902072

Abstract

Cancer development and progression is strongly associated with somatic mutations. From oncogenic hits that initiate the primary tumor formation to metastasis, the tumor mutational burden (TMB) plays a prominent role in the disease progression for the vast majority of cancer types. Not only are heterogeneous mutational loads or genetic heterogeneity causal to transcriptomic and proteomic discrepancies and to phenotypic diversity between individuals, they are also between tumor cells. But in addition to mutations, a [...]

1839 11738

Open Access Review

Engagement and Utilization of Advance Care Planning and Hospice in Different Older Asian American Populations

Received: 31 October 2018;  Published: 08 April 2019;  doi: 10.21926/obm.geriatr.1902046

Abstract

This research review sought to examine the patterns of engagement in advance care planning (ACP) and utilization of end-of-life (EoL) care treatment services including, but not limited to hospice care, in distinct older Asian American ethnic groups. The review of existing research suggested evidence that empirical studies about different older subpopulations of Asian Americans remains scarce. This research analysed 30 small-scale studies on older Asian Americans’ attitudes and engagement in EoL care planning. The r [...]

2244 15429

Open Access Review

Right Heart Failure in Left Ventricular Assist Device Patients

Received: 13 February 2019;  Published: 08 April 2019;  doi: 10.21926/obm.transplant.1902060

Abstract

Left ventricular assist devices (LVADs) improve quality of life in end-stage heart failure patients but a frequent complication is Right heart failure (RHF) causing significant morbidity and mortality. This review article discusses key issues that need to be considered in the assessment and clinical management of RHF in LVAD patients including the use of Right Ventricle (RV) support devices and off-label LVADs as temporary or permanent RV support.

1802 15615

Open Access Comment

hTERT Promoter Regulation by Differentiation Mechanisms vs Telomerase Activity in Somatic, Embryonic, and Cancerous Cells

Received: 02 February 2019;  Published: 04 April 2019;  doi: 10.21926/obm.geriatr.1902045

Abstract

Telomere shortening in the somatic cells is one of the most well-documented factors of cellular ageing. Telomeres are composed of tandem hexanucleotide repeats that protect cells from unwanted recombination mechanisms, secure the ends of chromosomes and their stability, and are responsible for limited division capacity. Telomerase is an enzymatic ribonucleoprotein complex, present in embryonic cells, adult stem cells, and germinal progenitors, whose function is to extend the telomeres length by adding the lost tand [...]

1654 13829

Open Access Research Article

Examining the Effectiveness of Two Types of Forgiveness Intervention to Enhance Well-Being in Adults from Young to Older Adulthood

Received: 30 October 2018;  Published: 03 April 2019;  doi: 10.21926/obm.geriatr.1902044

Abstract

Background: Interventions that facilitate positive actions and attitudes seem to play an important role in enhancing psychological health. This study examines the effectiveness of two self-guided interventions with the aim to enhance adults’ well-being through the cultivation of forgiveness skills. Methods: A total of 11 men and 31 women aged 34-80 years were involved (M = 56.57, S.D. = 13.44). All participants were Orthodox Christians, as the average Greeks are, without belonging to a closed religious community. T [...]

2227 23773

Open Access Research Article

Gluten-Free Diet for the Treatment of ADHD; Pilot Study

Received: 17 December 2018;  Published: 03 April 2019;  doi: 10.21926/obm.neurobiol.1902024

Abstract

Background: The association between Attention Deficit Hyperactivity Disorder (ADHD) and celiac disease has already been established. Non-celiac gluten sensitivity (NCGS), as well as celiac disease, has been associated with neuro-psychiatric disorders. Our objective is to assess if a proportion of pediatric ADHD patients are affected by NCGS and could consequently benefit from a gluten-free diet. Methods: Pilot study of 6 ADHD patients. Personal or family history suggestive of NCGS was investigated. The Conners Cont [...]

2414 28325

Open Access Review

Islet Autotransplantations for Total Pancreatectomy

Received: 15 January 2019;  Published: 03 April 2019;  doi: 10.21926/obm.transplant.1902059

Abstract

Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease such as chronic pancreatitis or pancreatic injury. However, because this surgery involves removal of the whole pancreas, both exocrine and endocrine pancreatic functions are abolished, significantly impairing the nutritional statuses of patients as well as having other detrimental outcomes. Thus, especially in benign cases additional treatment to recover endocrine function is recommended, as permanent endocrine [...]

1314 9452

Open Access Research Article

Prevalence of Viral Liver Disease and Oral Lichen Planus in Patients Who Visited Dental Clinics: A Study by the Ehime Dental Association

Received: 12 January 2019;  Published: 02 April 2019;  doi: 10.21926/obm.hg.1902016

Abstract

Background: The association between hepatitis C virus (HCV) infection and oral lichen planus (OLP), an extrahepatic manifestation, is well known. There are still patients with viral liver disease in this country who are not receiving appropriate treatment. This prospective study aimed to evaluate the prevalence of OLP and untreated hepatitis virus infection in patients who visited dental clinics in Ehime prefecture, in western Japan. Methods: Patients who visited 35 dental clinics in Japan from March 2018 to June 2 [...]

1233 7070

Open Access Original Research

Comparison of Respiratory Sinus Arrhythmia between Zen-meditation and Control Groups

Received: 30 July 2018;  Published: 01 April 2019;  doi: 10.21926/obm.icm.1902021

Abstract

Background: This research aims to develop new methods to investigate the cardiorespiratory interaction of Zen-meditation practitioners (Zen-meditation group) and healthy ordinary young people (control group) by quantitatively evaluating respiratory sinus arrhythmia (RSA) behavior. Methods: Twenty-five voluntary controls and seven Zen-meditation practitioners were recruited. The experimental protocol involved five sessions of different mental-stress levels (control group) and five sessions of Zen-meditation practice [...]

2284 17526

Open Access Review

Molecular Mechanisms of Canine Cancers

Received: 30 January 2019;  Published: 01 April 2019;  doi: 10.21926/obm.genet.1902071

Abstract

Cancer is the leading cause of death in dogs, and 50 percent of dogs over the age of 10 develop cancer at some point. The most common cancers in dogs include lymphoma, mast cell tumors, osteosarcoma, mammary gland tumors, and melanoma, and many of them share marked similarities with their human counterparts. Although canines are afflicted with many of the same types of cancers as humans, the genetic basis behind these cancers are not as well understood. Thus, the aim of this study is to elucidate some of the molecu [...]

2392 17449

Open Access Review

The Role of Mitochondria in Oocyte and Early Embryo Health

Received: 01 January 2019;  Published: 29 March 2019;  doi: 10.21926/obm.genet.1901070

Abstract

The mitochondria of the oocyte are a prominent source of energy metabolism as well as mitochondrial DNA that will later populate the cells of the offspring. Recent discoveries provided new insight into the physiology of the mitochondria and its unique genetics. The concept of heteroplasmy defined as the presence of more than one type of mitochondrial genome, is gaining increasing recognition as an important contributor to several complex morbidities, age-related reproductive dysfunction and aging. Understanding the [...]

2966 29770

Open Access Original Research

The Positive Power of Perception in Late Life: A Study on Subjective Aging and Health among Ethnic Minorities

Received: 17 September 2018;  Published: 29 March 2019;  doi: 10.21926/obm.geriatr.1901043

Abstract

Background: The world’s aging population is growing and diversifying at an unprecedented rate. In preparation for this, the National Institutes of Health and the Centers for Disease Control and Prevention have issued calls to improve the overall health of older adults. A promising avenue of research to improve health in late life has been dedicated to subjective aging; the way people perceive their own aging process. The main objective of this empirical study was to investigate subjective aging in late life among e [...]

2017 66588

Open Access Editorial

Depression and Aging: Role of Social Support

Received: 25 March 2019;  Published: 28 March 2019;  doi: 10.21926/obm.geriatr.1901042

Abstract

Depression and Aging: Role of Social Support

1986 11008

Open Access Original Research

Acupuncture for Chemo-Related Nausea and Vomiting

Received: 29 September 2018;  Published: 28 March 2019;  doi: 10.21926/obm.icm.1901020

Abstract

Background: In recent years, complementary and alternative medicine (CAM) techniques have become very widespread; among these, acupuncture can play an important role in the treatment of adverse effects related to chemotherapy. This role has been recognized by the National Institutes of Health after many clinical studies, thus allowing the official introduction of acupuncture in supportive therapy for oncological diseases, particularly to prevent nausea and vomiting. The aim of this paper is to describe the activity [...]

2378 12566

Open Access Review

Ischemic Brain Injury and Regulatory T Cells

Received: 13 January 2019;  Published: 27 March 2019;  doi: 10.21926/obm.neurobiol.1901023

Abstract

Inflammation and immune responses after stroke, including ischemic cerebral infarction, play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues, which subsequently regulate effector T cell activation and dendritic cell activation. Recently, Tregs that are present in tissues, called tissue Tregs, have been shown to exhibit tissue-specific functions in addition [...]

1944 13101

Open Access Review

Endoscopic Management of Crohn’s Disease Strictures

Received: 28 January 2019;  Published: 26 March 2019;  doi: 10.21926/obm.hg.1901015

Abstract

Crohn’s disease is a chronic inflammatory condition of the gastrointestinal tract which can result in luminal stenosis and up to 90% of patients requiring surgery during their lifetime. Medical management aims to reduce the inflammatory burden to prevent the development of inflammatory strictures, progression to fibro-stenosis and subsequent obstructive symptoms. Endoscopic balloon dilatation (EBD) is a well-established, safe technique in the management of short strictures to prevent patients having multiple surgic [...]

1221 9896

Open Access Case Report

Increase in Electrodermal Activity on Acupuncture Points of Lymphatic, Lung, Nervous, Endocrine and Heart Meridians after Running Exercise, a Single Case Study

Received: 10 December 2018;  Published: 25 March 2019;  doi: 10.21926/obm.icm.1901019

Abstract

Background: Electrodermal measurement of acupuncture points has been correlated to physiologic and pathologic conditions with clinical and laboratory studies. Emerging evidence indicates that in addition to therapeutic effect, acupuncture points may also have diagnostic properties. However, physiologic basis of this phenomenon is still unknown. Objective: To determine how electrodermal activity of acupuncture points on hands and feet responds to exercise-induced sympathetic stress and how electrodermal measurement [...]

2383 18083

Open Access Opinion

Clonal Heterogeneity in Non-Small Cell Lung Cancer and the Possible Role in Predicting Response to Treatment with Immune Checkpoint Inhibitors

Received: 15 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.genet.1901069

Abstract

Immune oncology treatment with immune checkpoint inhibitors (ICIs) is revolutionizing therapeutic approach for advanced non-small cell lung cancer (NSCLC) patients, in terms of longer survival and improved quality of life. To date, the widely used and approved biomarker is programmed death ligand 1 (PD-L1) expression on tumour cells, but it is considered not accurate and it is more likely that many factors, related to both cancer and host, may better predict response to ICI. Among those factors, great attention is [...]

1969 9435

Open Access Case Report

Secondary Antibody Deficiency in a Heart Recipient with Systemic Aspergillosis

Received: 23 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.transplant.1901058

Abstract

Secondary antibody deficiency has been associated with risk of invasive fungal infections in solid organ transplantation. Single center, multi-center and meta-analysis studies have tested this association. Therapy of these infectious complications in the presence of a secondary antibody deficiency after transplantation remain a challenge for transplant teams. Currently, there are no guidelines for the management of this combined clinical scenario. We report the case of a patient with severe secondary immunodeficien [...]

1727 8918

Open Access Review

Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and Hostility

Received: 28 December 2018;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901041

Abstract

Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to stressors show notable circulating inflammatory responses with high cortisol reactivity, which increases cell turnover and oxidative stress and may subsequently contribute to shortened TL. This review focuses on the most [...]

2306 13421

Open Access Review

Does Dementia Increase the Risk of Dental Decay?

Received: 09 January 2019;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901040

Abstract

The amount of patients who suffer with dementia is set to rise with an ageing population. As well as living longer, patients will be retaining their natural teeth into their later life and will be less reliant on dentures. From both the current evidence available in the literature, and anecdotally from clinicians experienced in treating patients with dementia, it can be concluded that on balance, patients with dementia appear to be at a greater risk from dental caries (dental decay). However, more research in this [...]

1974 17457

Open Access Short Review

The Effects of Aquatic Exercise on Cognitive Function: Systematic Review

Received: 07 February 2019;  Published: 21 March 2019;  doi: 10.21926/obm.icm.1901018

Abstract

The objective of this brief systematic review was to examine the effects of aquatic exercise on cognitive function. Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar. In total, 13 articles met the inclusionary criteria. Among the 13 studies, all 13 demonstrated beneficial cognitive effects from exercise. This included chronic aquatic exercise-induced improvements in global cognition, executive function, attention, learning and memory, cognitively-relat [...]

3637 16478

Open Access Perspective

Behavioural and Complementary Interventions for Healthy Neurocognitive Aging

Received: 30 November 2018;  Published: 20 March 2019;  doi: 10.21926/obm.geriatr.1901039

Abstract

Background: While the percent of persons 65 and older is expected to increase to 17% of the world’s population by 2050, this increase in longevity does not necessarily suggest a parallel increase in health status. While aging is an inevitable aspect of living, there are factors which can accelerate morbidity and mortality, as well as factors likely to promote a healthy transition into longevity. This paper addresses behavioural and complementary interventions for healthy neurocognitive aging. Specific evidence-base [...]

3749 22206

Open Access Technical Note

Interphase Quantitative Fluorescence in Situ Hybridization (IQ-FISH)

Received: 02 February 2019;  Published: 20 March 2019;  doi: 10.21926/obm.genet.1901067

Abstract

Fluorescence in situ hybridization (FISH) seems to be the most applicable and versatile molecular cytogenetic platform for visual interphase chromosome analysis offering a variety of opportunities for studying chromosomal structure and behaviour at the highest microscopic resolution and at all stages of the cell cycle. Quantitative assessment of FISH results has been repeatedly shown to increase the efficiency of FISH-based approaches. Here, we explore the potential of interphase quantitative FISH (IQ-FISH), which [...]

2022 11623

Open Access Review

FISH-Based Analysis of Mosaic Aneuploidy and Chromosome Instability for Investigating Molecular and Cellular Mechanisms of Disease

Received: 08 February 2019;  Published: 20 March 2019;  doi: 10.21926/obm.genet.1901068

Abstract

Recently, numerous studies have reported convincing data suggesting that chromosome instability may be not only a trigger of cancers but a possible mechanism for a wide spectrum of brain diseases. According to our original experience, chromosome instability is commonly observed during karyotyping of children with neuropsychiatric diseases and congenital malformations. To understand mechanisms of non-cancerous diseases potentially mediated by chromosome instability, which may represent an important target for molecu [...]

2001 11006

Open Access Research Article

New DNA Extraction Method for the Detection of Pneumocystis in Lung Tissue Samples of Colonized Individuals

Received: 30 January 2019;  Published: 18 March 2019;  doi: 10.21926/obm.genet.1901066

Abstract

Background: Pneumocystis jirovecii colonization in patients is associated with a low organism burden, which supports the need to use highly sensitive molecular techniques, such as nested-PCR to determine the presence of the organism. However, few studies have considered the effect of nucleic acid extraction methods on the detection of P. jirovecii. Here, we evaluate how pre-treatment affects microbial detection. Methods: Lung tissue samples from fifteen autopsied infants were processed using two different DNA extra [...]

1934 11034

Open Access Communication

Proposal for a Compassionate Emotional Accompaniment Technique (CEAT) Based on Mindfulness to Manage Disturbing Emotions

Received: 23 August 2018;  Published: 14 March 2019;  doi: 10.21926/obm.icm.1901017

Abstract

One of the objectives of psychological intervention is to help patients manage their emotions effectively by providing them with the necessary skills to accompany their own emotional states. To this regard, there seems to be a current lack of therapeutic resources aimed at helping patients assimilate and regulate emotions. This article proposes the application of a new technique which incorporates mindfulness, building on the premises of the model of psychological flexibility which defines "mindfulness" as a practi [...]

2144 12127

Open Access Review

New Insights to Prevent Liver Fibrosis by Targeting YB-1 and Collagen Genes

Received: 20 December 2018;  Published: 13 March 2019;  doi: 10.21926/obm.hg.1901014

Abstract

Liver fibrosis leading to cirrhosis and cancer affects millions of people and causes thousands of deaths all over the world. Many signaling pathways could be targeted to block fibrosis but these are not successful. Reviewing recent literature and from our own studies we identified novel target, such as YB-1, which is implicated in inflammation, angiogenesis and accumulation of extracellular matrix (ECM). In addition we observed and showed that the end product of fibrosis, collagen gene, itself is a direct target fo [...]

1367 6983

Open Access Review

Diffuse Intrinsic Pontine Glioma: Translation of Genomic Knowledge to Clinical Practice

Received: 29 November 2018;  Published: 12 March 2019;  doi: 10.21926/obm.neurobiol.1901022

Abstract

Pediatric brain tumors account for approximately 25% of all cancers in children and are currently the leading cause of cancer-related deaths in the pediatric population with an estimated incidence of 5.14 cases per 100,000 person years [1]. Up to 10-15% of all pediatric brain tumors arise in the brainstem, with the majority of these classified as the diffuse intrinsic pontine glioma (DIPG) subtype [2]. The outcome of children with DIPG remains dismal with a median survival of <1 year. Owing to the unique locatio [...]

1882 13499

Open Access Case Report

Prolonged and Resistant Cutaneous Infection in Newly Transplanted Renal Patient

Received: 18 October 2018;  Published: 07 March 2019;  doi: 10.21926/obm.transplant.1901057

Abstract

Mucormycosis is an angioinvasive and potentially fatal fungal infection caused by ubiquitous filamentous fungi. Cutaneous mucormycosis is an emerging infection and potentially lethal. Our aim was to review the literature on cutaneous mucormycosis. We present a case of a renal transplant patient with a surgical wound infection 20 days after kidney transplant. This case is an example on how early diagnosis is crucial and, since culture is less sensitive, microscopic evaluation of the characteristic broad hyphae is th [...]

1350 8076

Open Access Research Article

The Contribution of Psychotherapists to Patient Care in Multidisciplinary Heart Transplantation Care Teams

Received: 28 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.transplant.1901056

Abstract

Background: The participation of mental health professionals in multidisciplinary care teams for heart transplantation has become an international standard practice. The contribution of these professionals in this setting, which involves assessment and interventions, has not been the subject of systematic study. Methods: This paper explores how psychotherapists contribute to multidisciplinary decision making and care in transplant teams before, during, and after transplantation. To illustrate, it uses the case of a [...]

1898 10670

Open Access Review

Islet Identity in Transplantation Procedures: The Intersection of Cellular Maturity and Function

Received: 08 November 2018;  Published: 05 March 2019;  doi: 10.21926/obm.transplant.1901055

Abstract

Pancreatic islet transplantation holds promise for patients with insulin-dependent diabetes, but is severely limited by a shortage of cadaveric donor islets, and more so because of stringent inclusion criteria for organ donation including donor metabolic function, age, and comorbidities. The impact of these diverse factors on islet health has led to a broad investigation of global influences on islet biology, not least of all, characterization of mature, functional cellular identity and maintenance of appropriate e [...]

2036 10310

Open Access Original Research

Prediction of ADRs and Estimation of Polypharmacy in Older Patient’s Population: Retrospective Study in Russian Gerontology Center

Received: 10 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.geriatr.1901038

Abstract

Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. Prediction of ADRs is a valuable tool to improve pharmacotherapy and outcomes in this category of patients. Objective: Prediction of ADRs in patients ≥ 65 years old, based on GerontoNet risk score with emphasis on polypharmacy. Methods: Pharmacoepidemiological retrospective study of medical records of patients admitted to the Russian Gerontology Clinical Research Center (RGCRC) between 1 [...]

1921 12307

Open Access Research Article

Psychophysiological Coherence in Community Dynamics – A Comparative Analysis between Meditation and Other Activities

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901015

Abstract

Background: Psychophysiological coherence has been widely studied as a bodily state associated with general well-being and cognitive clarity. Heart Rate Variability (HRV) has been shown to be a good biomarker to assess psychophysiological coherence. This paper presents the first general set of results concerning a study that is part of a team effort between a body of researchers in 5 countries led by the HeartMath Institute under the name, International Heart Rate Variability Synchronization (IHRVS) Study. This stu [...]

2238 14151

Open Access Editorial

Compassion in Clinical Care

Received: 01 March 2019;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901016

Abstract

Compassion in Clinical Care

2008 8683

Open Access Review

Sporadic and Hereditary Hemangioblastoma: The Role of Endothelial Cells

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.neurobiol.1901021

Abstract

Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. Approximately 75% of HBs are sporadic, while 25% are associated with von Hippel–Lindau (VHL) disease. HBs consist of two main components: a rich capillary network composed of vascular endothelia and pericytes, within large vacuolated stromal cells, which harbor the genetic defect. The mechanism by which the VHL gene product (pVHL) causes HB is not completely clear. Wild-type pVHL is involved in the response to hypoxia, tar [...]

1723 12139

Open Access Research Article

New Tools in Cognitive Neurobiology: Biotin-Digoxigenin Detection of Overlapping Active Neuronal Populations by Two-Color c-fos Compartment Analysis of Temporal Activity by Fluorescent in situ Hybridization (catFISH) and c-Fos Immunohistochemistry

Received: 12 October 2018;  Published: 04 March 2019;  doi: 10.21926/obm.genet.1901065

Abstract

Background: The method of cellular compartment analysis of temporal activity by fluorescent in situ hybridization (catFISH) is widely used in cellular and behavioral neurobiology. This technique exploits stimulus-induced expression of immediate early genes (IEGs) and allows identification of two neuronal populations activated in the brain of the same animal in response to neural or behavioral events separated by 25–30 min. The differential labeling is based on the visualization of nuclear RNA and cytoplasmic [...]

2734 18670

Open Access Review

Role of Procalcitonin in Management of Infection in Solid Organ Transplantation Recipients: Review

Received: 23 December 2018;  Published: 01 March 2019;  doi: 10.21926/obm.transplant.1901054

Abstract

Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation of PCTs value in the different types of infections, transplanted organs, and post-operative courses can be challenging. We review the role of PCT in the management of infections in SOT recipients. First, the PCT level c [...]

2167 14841

Open Access Original Research

Exploring the Paradox of Care: Differences in Older Adult and Proxy Ratings of Health and Subjective Well-Being

Received: 27 August 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901037

Abstract

Background: The purpose of this study was to examine discrepancies in self-proxy agreement of biopsychosocial factors and the influence of objective well-being and psychosocial resources self and proxy appraisals of subjective well-being in older adults. Methods: Seventy-two older adult-proxy dyads rated the biopsychosocial health of non-cognitively impaired older adults. Results: Proxies underestimated functional ability, psychosocial factors, and overrated negative health outcomes compared to older adults. Older [...]

1750 11248

Open Access Technical Note

Improving the HealthCare of People with Dementia beyond the Diagnosis: The “Carlo Poma Dementia Care Pathway” Study Protocol

Received: 31 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901036

Abstract

The WHO global action plan on the public health response to dementia 2017-2025 stressed the need to have a comprehensive approach with deep interconnections and cross-cutting elements through several action areas. As the elderly population grows worldwide, the number of patients with dementia increases rapidly because age is an important risk factor for developing late-onset dementia. Currently, dementia syndrome represents a true emergency. Once a diagnosis of dementia was made, informal caregivers, patients and t [...]

1748 14204

Open Access Editorial

The Treatment of the Nervous System with Complementary and Alternative Medicine

Received: 25 February 2019;  Published: 27 February 2019;  doi: 10.21926/obm.icm.1901014

Abstract

The nervous system is everywhere in the body, especially in the skin. Ancient Chinese acupuncture charts show us that the nerves are all connected and can work together to promote health. This connection occurs through the brain and brain stem. It is clear that acupuncture is analgesic by inhibition of transient receptor potential cation channels in the skin [1]. The role of chemokines in pain is becoming understood. Chemokines promote pain in the skin and activate ascending neural pathways that regulate chemo [...]

1940 9012

Open Access Case Report

Candida auris and Heart Transplantation. Preoperative Attitude.

Received: 15 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.transplant.1901053

Abstract

In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multidrug-resistant yeast that is associated with serious infections and with a mortality rate that can reach 70%. This problem is especially serious in transplant recipients receiving intense immunosupressive therapy. There are no established criteria on the relevance of this colonization or on when the transplant should be contraindicated in these cases. Five cases of colonization and two of candidemia have been [...]

1994 11867

Open Access Hypothesis

Sporadic Alzheimer Disease and That Developing in Down’s Syndrome: The Immune System Attacking Self Rather Than Suppressing Infectious Disease Invaders, Toll Like Receptors Triggering Excessive Cytosolic Calcium, Excess Calcineurin Activation, Overexpression of Regulator of Calcineurin1, Runaway Beta-Amyloid Production, Synaptic Loss, Destructive Inflammation and Dementia

Received: 29 August 2018;  Published: 26 February 2019;  doi: 10.21926/obm.geriatr.1901035

Abstract

Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self-recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloid production (a component of the innate immune system) causing cytosolic calcium overload. Excessive cytosolic calcium may cause over activation of calcineurin and inactivation of cis-trans prolyl isomerase (Pin1), with [...]

1670 9911

Open Access Concept Paper

New Paradigm in International Ear Acupuncture

Received: 16 October 2018;  Published: 26 February 2019;  doi: 10.21926/obm.icm.1901013

Abstract

Background: In the international auriculotherapy practice there are relatively big differences in the exact localization of the same ear acupuncture point. On one hand, there are specialists who devote their efforts to find the active points. In that case it becomes intriguing that there may be another point (at 1-2 mm distance) near the point to be treated, indicating a relatively strong, even stronger activity than the one they were initially aiming to find. That point may be active because of another health prob [...]

3433 46033

Open Access Review

Advances in Human Islet Processing: Manufacturing Steps to Achieve Predictable Islet Outcomes from Research Pancreases

Received: 15 October 2018;  Published: 26 February 2019;  doi: 10.21926/obm.transplant.1901052

Abstract

Background: This presentation of a six-year study processing human islets for research and transplantation includes a review of multi-center transplant studies identifying key variables critical for successful islet processing and defines standardized processing procedures required to provide highly purified, functional Human Islets. Methods: Human islet processing methods are defined in detail with pancreas retrieval, shipping, trimming for processing, collagenase distension, controlled digestion by digestion/filt [...]

2343 17195

Open Access Case Report

Chronic Pain after Reported Whiplash Injury – A Patient Case Report

Received: 13 April 2018;  Published: 25 February 2019;  doi: 10.21926/obm.icm.1901012

Abstract

Chronic pain is notoriously multifactorial, multifaceted and difficult to manage. Twenty per cent of reported whiplash-injured persons go on to develop a Whiplash Associated Disorder (WAD) where persistent pain becomes chronic with no prospect of change [1]. Paucity of effective therapies to address the effect of WAD enforces new approaches. This case report, with a patient’s perspective, illustrates a novel therapy, Adapted Reflextherapy (AdRx), which is akin to reflexology and has been used, developed and revised [...]

2120 17397

Open Access Review

A Brief Primer on Learning and Memory-Based Strategies to Enhance Memory Function

Received: 17 December 2018;  Published: 21 February 2019;  doi: 10.21926/obm.icm.1901011

Abstract

Background: Learning and memory, unquestionably, are critical for many aspects of life, including acquisition and retention of educational material. The purpose of this brief narrative review is to provide a primer on empirical-based, learning and memory techniques. Methods: A narrative review approach is employed. Results: This review is structured by first discussing contextual factors that influence learning and memory, followed by addressing several specific techniques to help facilitate learning and memory ret [...]

2243 10823

Open Access Research Article

Aspiration of Gastrointestinal Material and Induction of Fibronectin Expression in Lung Transplant Recipients: Implications for Early Airway Remodeling

Received: 29 November 2018;  Published: 20 February 2019;  doi: 10.21926/obm.transplant.1901051

Abstract

Background: Gastroesophageal reflux disease has been associated with the development of chronic lung allograft dysfunction following lung transplantation. While the mechanisms are unclear, it is postulated that microaspiration of gastrointestinal material (GIM) leads to inflammation and airway remodeling that culminates in obliterative bronchiolitis. As the expression of the matrix glycoprotein fibronectin has been shown to be an early marker of this fibroproliferative process, its induction could suggest a causal [...]

1554 8828

Open Access Research Article

COMBO-FISH: A Versatile Tool Beyond Standard FISH to Study Chromatin Organization by Fluorescence Light Microscopy

Received: 14 September 2018;  Published: 19 February 2019;  doi: 10.21926/obm.genet.1901064

Abstract

Background: Fluorescence In Situ Hybridization (FISH) has become routine for bio-medical research and medical diagnosis, thereby offering a variety of probes and ready-to-use kits that fulfil requirements for many applications. However, conventional FISH relies on chemical and/or thermal denaturation to improve target accessibility and uses huge amounts of DNA that needs to be bonded to the target site. COMBinatorial Oligo-nucleotide FISH (COMBO-FISH) offers possibilities to circumvent these shortcomings. Methods: [...]

2391 15232

Open Access Review

Cell Senescence, Telomerase, and Senolytic Therapy

Received: 31 December 2018;  Published: 15 February 2019;  doi: 10.21926/obm.geriatr.1901034

Abstract

The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable attention, but both theoretical considerations and published data suggest that the clinical benefits will be transient and that senolytic therapies will likely accelerate long-term degenerative disease. We review the ove [...]

2532 37829

Open Access Technical Note

An Initial Investigation of Neural Changes in Overweight Adults with Food Cravings after Emotional Freedom Techniques

Received: 11 December 2018;  Published: 15 February 2019;  doi: 10.21926/obm.icm.1901010

Abstract

Background: This pilot randomised clinical trial investigated the effect of Clinical Emotional Freedom Techniques (EFT) on brain activation in response to food craving stimuli using functional magnetic resonance imaging. EFT is a brief stress reduction technique which involves stating a cognitive statement with stimulation of acupressure points with a tapping technique. Method: Fifteen overweight/obese adults were allocated to a four-week group EFT treatment or control condition and completed a measure of food crav [...]

3027 878397

Open Access Research Article

Effect of Six-Months Supplementation with Cholecalciferol on Glycemic and Blood Pressure Control in Elderly Type 2 Diabetic Patients with Vitamin D Deficiency: A Pilot Study

Received: 31 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.geriatr.1901033

Abstract

Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. Our aim was to evaluate in elderly uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-months vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels. Methods: In an open-label pilot study, thirty type 2 diabetic patients (age 71.5 ± 3.2 years, BMI [...]

1925 11134

Open Access Review

New Frontiers in Solid Organ Transplantation from Donors with Human Immunodeficiency Virus, Hepatitis C Virus Infection, and Multidrug Resistant Organisms

Received: 26 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.transplant.1901050

Abstract

Despite the advances that have been made in the field of solid organ transplant (SOT), organ shortage remains a persistent problem. In addition, the donor pool has been changing with the ongoing opioid epidemic and increase in deaths related to drug overdose each year. More donors are meeting the 2013 United States (U.S.) Public Health Service criteria for increased risk donors (IRDs), or donors who are at higher risk for transmission of Human Immunodeficiency Virus (HIV), Hepatitis C virus (HCV), and other multidr [...]

1790 9231

Open Access Editorial

Sex and Gender Issues in Heart Transplantation

Received: 01 February 2019;  Published: 13 February 2019;  doi: 10.21926/obm.transplant.1901049

Abstract

Sex and gender issues in heart transplantation

1921 10613

Open Access Review

Tuberculosis Screening and Treatment in Solid Organ Transplantation

Received: 18 November 2018;  Published: 12 February 2019;  doi: 10.21926/obm.transplant.1901048

Abstract

Background: Tuberculosis (TB) is a common infection with challenges in diagnosis and treatment. Management of TB in solid organ transplant (SOT) candidates and recipients poses unique challenges not seen in other populations. Questions and Recommendations: Latent TB infection (LTBI) is important to diagnose pre-transplant through history, physical examination, imaging, and laboratory tests. Tuberculin skin tests and interferon-gamma release assays are important tools but not sufficiently sensitive nor specific to d [...]

1818 13530

Open Access Research Article

Key Dimensions of Therapeutic Lies in Dementia Care: A New Taxonomy

Received: 12 December 2018;  Published: 11 February 2019;  doi: 10.21926/obm.geriatr.1901032

Abstract

Background: Research suggests that the use of lies and deception is prevalent within dementia care settings, despite ongoing debates raised about the ethics of this approach. There has been increasing exploration of when and why deceptive practices should be used, but the lack of clarity as to what constitutes a lie has caused difficulty in ensuring that lies are used ethically. The aim of this study was to widen our understanding of the key dimensions that underpin the use of lies, and further to use this informat [...]

2315 17744

Open Access Original Research

An Evaluation of a New Programme Training Mindfulness Teachers to Deliver Non-Eight Week Adapted Mindfulness-Based Interventions

Received: 13 October 2018;  Published: 02 February 2019;  doi: 10.21926/obm.icm.1901009

Abstract

Background: Training is generally not available for those wishing to deliver non 8 week Mindfulness Based Interventions (MBIs) adapted for specific contexts and populations. A new model for training in MBIs is developed with the following principle components: teaching on theory, participation in a practice, followed by teaching the practice and receiving feedback, and consultation and discussion of live mindfulness-based work. Methods: A quantitative and qualitative evaluation is presented of the experience of the [...]

2046 10073

Open Access Research Article

Integrated Oncology in an Integrated Medicine Hospital in Pitigliano (Grosseto, Italy)

Received: 29 September 2018;  Published: 01 February 2019;  doi: 10.21926/obm.icm.1901008

Abstract

Background: Complementary medicines (CM), including homeopathy, acupuncture, and traditional Chinese medicine, have been introduced for cancer patients undergoing chemotherapy and radiotherapy treatment in the Pitigliano Hospital Centre of Integrated Medicine in order to minimize the side effects of these treatments, which improves quality of life and adherence to conventional therapies. Methods: Cancer patients (240) were enrolled in an integrated care model offering a comprehensive protocol including homeopathy a [...]

1951 9581

Open Access Perspective

Solid Organ Transplantation in Older Adults. Infectious and Other Age-Related Considerations

Received: 30 November 2018;  Published: 01 February 2019;  doi: 10.21926/obm.transplant.1901046

Abstract

In the U.S., older adults aged 65 or above comprise nearly one quarter of the solid organ transplant (SOT) waitlists, and the number of transplants performed in this age group continues to increase. There are no specific guidelines for the assessment and follow up of the older SOT candidate or recipient. Older adults are at increased risk of infectious complications after SOT. Despite these complications and even with the use of suboptimal donors, overall outcomes are favorable. We provide an overview to specific c [...]

2100 11275

Open Access Review

Challenges in Diagnosis and Management of Nontuberculous Mycobacteria in Solid Organ Transplantation

Received: 30 November 2018;  Published: 01 February 2019;  doi: 10.21926/obm.transplant.1901047

Abstract

Nontuberculous mycobacteria (NTM) infections are relatively rare but carry significant morbidity in solid organ transplant (SOT) recipients. Given the rarity of disease and diagnostic limitations, a high index of suspicion is required for accurate diagnosis and initiation of appropriate treatment. We discuss the challenges in diagnosis and management of NTM infections specific to the SOT population.

1643 10375

Open Access Review

Is Self-Compassion Important for Health Care Practitioners?

Received: 25 November 2018;  Published: 31 January 2019;  doi: 10.21926/obm.icm.1901007

Abstract

The cornerstone of health care practice is the provision of competent, compassionate care. Compassion is generally considered an important component in the provision of health care; however, self-compassion may be of equal importance for health care practitioners (HCP) to observe and develop. Self-compassion promotes well-being and overall mental health and may reduce fatigue and “burn-out” for HCPs [1]. Estimates of burn out in physicians and nurses range from 35-50% and is associated with emotional exhaustion, hi [...]

2875 17636

Open Access Review

Innate Immune Determinants of Graft-Versus-Host Disease and Bidirectional Immune Tolerance in Allogeneic Transplantation

Received: 29 September 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901044

Abstract

The success of tissue transplantation from a healthy donor to a diseased individual (allo-transplantation) is regulated by the immune systems of both donor and recipient. Developing a state of specific non‐reactivity between donor and recipient, while maintaining the salutary effects of immune function in the recipient, is called “immune (transplantation) tolerance”. In the classic early post‐transplant period, minimizing bidirectional donor ←→ recipient reactivity requires the administration [...]

2052 14400

Open Access Case Report

Isolated Hepatic Mucormycosis in the Early Post-Transplant Period: A Case Report and Literature Review

Received: 08 October 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901045

Abstract

Mucormycosis is a rare fungal infection associated with high morbidity and mortality that typically afflicts immunocompromised hosts. We present a case of isolated hepatic mucormycosis with Rhizopus spp. that developed in the early post-transplant period. Initial presentation was concerning for allograft rejection, but definitive diagnosis was made with histopathology and fungal culture. The patient had a favourable outcome with surgical resection, a course of liposomal amphotericin B combined with micafungin, and [...]

1649 10038

Open Access Editorial

Telomere Editorial - Perspectives on Telomeres and Aging

Received: 29 January 2019;  Published: 30 January 2019;  doi: 10.21926/obm.geriatr.1901031

Abstract

Telomere Editorial-Perspectives on Telomeres and Aging

2082 12574

Open Access Original Research

Acupuncture in Palliative Care

Received: 14 October 2018;  Published: 30 January 2019;  doi: 10.21926/obm.icm.1901006

Abstract

Background: Acupuncture is an innovative and scientifically supported treatment for oncologic patients, as well as an effective palliative care option. At the Palliative Care Department of "Misericordia" Grosseto Hospital in Tuscany, real integration of acupuncture in palliative medicine has been possible. The objective of this work is to retrospectively evaluate patient treatment outcomes obtained using an integrated medical care approach administered within a palliative care unit. Methods: Medical records of onco [...]

5894 14672

Open Access Research Article

Magnetic Resonance Imaging Approaches for Predicting the Response to Hyperoxic Radiotherapy in Glioma-Bearing Rats

Received: 11 November 2018;  Published: 30 January 2019;  doi: 10.21926/obm.neurobiol.1901020

Abstract

Background: Despite important advances in multimodal therapeutic options, glioblastoma (GBM), the most frequent and aggressive form of all astrocytomas, remains with a median overall survival period of 15 months. A direct correlation between GBM hypoxia and higher aggressiveness, poor prognosis and greater resistance to different treatments has been established. However, because of intratumoral and interindividual heterogeneity, it has not been possible to assess accurately the hypoxia degree from physiopathologica [...]

1910 11374

Open Access Review

Targeting Acute Islet Inflammation to Preserve Graft Mass and Long-Term Function

Received: 21 November 2018;  Published: 29 January 2019;  doi: 10.21926/obm.transplant.1901043

Abstract

Islet transplantation is a minimally invasive cell based replacement therapy to prevent or reverse diabetes or hypoglycemia through natural hormonal responses to regulate blood glucose. However, extending the islet graft functional lifespan remains a challenge that prevents long-term success and widespread use of the procedure. Islets are subject to stress and damage and undergo immunological assault during transplantation procedures. Current treatments to prevent immune reactivity toward the graft come with toxic [...]

1599 11576

Open Access Opinion

Interphase FISH: A Helpful Assay in Prenatal Cytogenetics Diagnosis

Received: 01 October 2018;  Published: 28 January 2019;  doi: 10.21926/obm.genet.1901063

Abstract

Since its introduction around the end of the 1970s, interphase fluorescence in situ hybridization (FISH) supports both classical and recent techniques for determining fetal karyotypes during prenatal diagnosis, quickly providing relevant information for the management of pregnancy. Interphase FISH plays an important role in the study of pregnancies with malformations, in mosaicism conditions, in confirming or excluding aneuploidy detected by non-invasive prenatal testing, and in the diagnosis of contiguous gene syn [...]

2600 25077

Open Access Technical Note

Repli-FISH (Fluorescence in Situ Hybridization): Application of 3D-(Immuno)-FISH for the Study of DNA Replication Timing of Genetic Repeat Elements

Received: 22 July 2018;  Published: 25 January 2019;  doi: 10.21926/obm.genet.1901062

Abstract

Background: Genetic repeat elements (interspersed or tandem repeats) have diverse functions within cells and at different phases of the cell cycle. However, their investigation at a genome-wide scale is challenging due to their repetitive nature. Here, we describe a method to study the DNA replication kinetics of different repeat elements in single cells throughout the S-phase of the cell cycle. Methods: Mouse major satellite, minor satellite and telomere repeat elements as well as human LINE-1 and Alu repeats were [...]

2496 767553

Open Access Research Article

An Examination of How the ‘Household Model' of Care Can Contribute to Positive Ageing for Residents in the ‘Fourth Age’

Received: 15 November 2018;  Published: 24 January 2019;  doi: 10.21926/obm.geriatr.1901030

Abstract

Background: Promoting a good quality of life for the oldest members of society has become a top priority as evidenced in UK policy. The ‘household’ model is a departure from traditional approaches to care provision since it offers person-centred support - combing health and social care - to older people in specially-designed, small, homelike environments. Having gained increasing popularity in care homes across developed countries, the impact of this model of service delivery on residents’ quality of life and its c [...]

2454 15675

Open Access Review

Where’s Waldo? Extrahepatic Site Options for Islet Transplantation

Received: 29 October 2018;  Published: 24 January 2019;  doi: 10.21926/obm.transplant.1901042

Abstract

The current predominant location for allo- and auto-transplantation of islets is the liver. Despite the historical success of this site, recent studies have revealed multiple disadvantages. Portal hypertension, portal vein thrombosis, bleeding, low oxygen tension, instant blood mediated inflammatory reaction, inadequate alpha cell function, and delays in neovascularization are factors that continue to drive researchers to explore alternative sites for islet transplantation. Factors of an optimal site include: capac [...]

1760 11997

Open Access Original Research

Mindful Self-Compassion and Adult Learner Retention in Post-Compulsory Education

Received: 15 July 2018;  Published: 23 January 2019;  doi: 10.21926/obm.icm.1901004

Abstract

Background: Adult learners often engage in formal education because they want to create changes in their lives and are determined to succeed in their chosen field. However, they also come with emotional "baggage" of early educational experiences, frequently have to deal with a multitude of competing demands, have financial strain, may face a lack of support, illness and/or injury. In addition, they are often dealing with the challenges of unfamiliar academic work, competing deadlines and initially lack basic academ [...]

2342 15204

Open Access Review

Ashitaba (Angelica keiskei) Exerts Possible Beneficial Effects on Metabolic Syndrome

Received: 18 July 2018;  Published: 23 January 2019;  doi: 10.21926/obm.icm.1901005

Abstract

Metabolic syndrome is a serious health condition comprising a combination of glucose metabolism disorder, high blood pressure and obesity. The main underlying risk factors for metabolic syndrome are abdominal obesity and insulin resistance. Various studies have shown that herbal medicines can effectively reduce the risk of developing metabolic syndrome. Angelica keiskei Koidzumi (ashitaba), a large perennial herb native to the Southeast Pacific coast of Japan, has recently become a popular herbal medicine, dietary [...]

3072 30390

Open Access Short Report

The Usefulness of Preimplantation Genetic Testing for Chromosome Aneuploidy Informed by A Randomised Controlled Trial

Received: 29 October 2018;  Published: 22 January 2019;  doi: 10.21926/obm.genet.1901061

Abstract

United Kingdom guidelines recommend single embryo transfer (fresh or cryopreserved) in the first full assisted conception cycle for women under 40 years most at risk of having twins. Based on a recent randomized clinical trial for women aged 36 to 40 years, the hypothetical effect of preimplantation genetic testing for chromosome aneuploidy was extrapolated to single transfer of every morphologically transferable embryo available from a full cycle. Offering testing to every woman seems likely to result in fewer cli [...]

1810 9504

Open Access Research Article

KAS Turns Four: The State of Deceased Donor Kidney Allocation in the U.S.

Received: 14 December 2018;  Published: 22 January 2019;  doi: 10.21926/obm.transplant.1901041

Abstract

Background: This study examines very recent trends in deceased donor kidney transplantation to assess the performance of the kidney allocation system (KAS), implemented December 4, 2014, and whether bolus effects associated with KAS have stabilized nearly four years after implementation. Methods: The overall number of deceased donor kidney transplants, as well as the proportion of transplants by recipient and transplant characteristics, were calculated monthly from December 2013 through September 2018 and examined [...]

2272 19785

Open Access Review

Parvovirus B19 Infection in Solid Organ Transplantation: Report of A Case and A Review

Received: 05 November 2018;  Published: 20 January 2019;  doi: 10.21926/obm.transplant.1901040

Abstract

Infection with parvovirus B19 is common, with up to 55% of adults showing seropositive evidence of prior infection. Clinical disease can occur due to acute infection, chronic persistent viremia, rarely secondary infection, or possibly viral reactivation of latent virus. The clinical presentation of primary infection depends on age, the presence of a hematologic condition, and immune status. We report a renal transplant recipient who developed transfusion dependent anemia refractory to erythropoietin that responded [...]

2125 15009

Open Access Review

Genotyping Pneumocystis jirovecii: Impacting Our Understanding of Interhuman Transmission

Received: 04 December 2018;  Published: 17 January 2019;  doi: 10.21926/obm.genet.1901060

Abstract

Pneumocystis jirovecii is an atypical fungus transmitted via the airborne route between humans. This fungus is exclusively associated with humans and almost each individual has encountered it at least once before reaching the age of two. P. jirovecii can be cleared and spontaneously resolutive in immunocompetent, whereas it can be responsible for severe Pneumocystis pneumonia (PCP) in immunocompromised patients. In the next decades, the putative increase of the population of immunocompromised patients is likely to [...]

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