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Table of Content

Open Access Case Report

Anticoagulation Rationale in an Elderly Patient with Stroke, Cerebral Amyloid Angiopathy, and Antiphospholipid Syndrome: A Case Report

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

Abstract

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

1681 7755

Open Access Research Article

Perceived Psychosocial Benefits for Individuals with Parkinson’s Disease Following Therapeutic Yoga: A Qualitative Analysis

Received: 19 August 2020;  Published: 22 December 2020;  doi: 10.21926/obm.geriatr.2004144

Abstract

Using a qualitative approach, this study explored the perceived impacts of a therapeutic yoga intervention for individuals with Parkinson’s disease (PD), and examined the beneficial components of the intervention. Eighteen individuals with PD who completed an eight-week yoga intervention participated in focus groups to determine the general effects, transference of effects, and psychosocial impact of the intervention. Additionally, programmatic aspects of the intervention were explored. A conventional content analy [...]

1740 10802

Open Access Research Article

Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Amyotrophic Lateral Sclerosis

Received: 12 October 2020;  Published: 17 December 2020;  doi: 10.21926/obm.geriatr.2004143

Abstract

Amyotrophic lateral sclerosis (ALS) is reported to be probably linked to frontotemporal lobar degeneration (FTLD). Since FTLD is characterized by severe frontotemporal degeneration along with hippocampal atrophy (HA), the present study used post-mortem 7.0-tesla magnetic resonance imaging to investigate whether a certain degree of HA occurs in the ALS brains as well. The examined post-mortem brain samples comprised 9 from the ALS cases and 17 from the age-matched controls. The hippocampus samples were examined on t [...]

1346 8508

Open Access Research Article

Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy

Received: 24 September 2020;  Published: 10 December 2020;  doi: 10.21926/obm.geriatr.2004142

Abstract

The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. The examined post-mortem brains included 30 AD-CAA cases and 20 AD [...]

1377 7495

Open Access Short Communication

An Algorithm to Optimize Pain Detection and Management in Older Patients in Routine Practice

Received: 09 July 2020;  Published: 07 December 2020;  doi: 10.21926/obm.geriatr.2004141

Abstract

Acute or persistent pain is a common occurrence and is often undertreated in older patients, especially those with an inability to communicate verbally (ICV). Regular comprehensive pain assessment, including self-rating and/or behavior scales, is critical but difficult to implement in routine clinical practice. The choice of the most appropriate scale for each patient is not easy, even for trained and skilled medical personnel. Indeed, the use of scales for short pain-behavior exposes to pain under-detection due to [...]

1768 11068

Open Access Original Research

Bridging Biomedical and Person-centered Care Approaches via Namaste Care with Family Participation: An Asian Experience in Advanced Dementia Treatment

Received: 27 October 2020;  Published: 04 December 2020;  doi: 10.21926/obm.geriatr.2004140

Abstract

A locally-adapted, multisensory, psychosocial intervention called Namaste Care program was developed to improve the daily life of persons with advanced dementia (PwAD) through arranging meaningful activities and physical interactions by healthcare staff (Namaste Carers). Congruent with Asian values, the families of PwAD were invited to participate in Namaste Care sessions. The study aimed to explore the influence of Namaste Care on cognitive status and quality of life (QOL) of PwAD, and perceptions and attitudes of [...]

2143 13696

Open Access Review

Rheumatic Diseases in the Elderly

Received: 13 August 2020;  Published: 18 November 2020;  doi: 10.21926/obm.geriatr.2004139

Abstract

Musculoskeletal conditions represent one-third to more than one-half of all non-communicable disease multimorbidities in the elderly, worsening their disability because of pain and limited physical function, often concurring with their mental decline. Musculoskeletal conditions significantly contribute to frailty and global disability, second only to mental health conditions. Furthermore, premature mortality, generally due to an increased risk of developing cardiovascular disease, has been documented in several rhe [...]

2321 17547

Open Access Research Article

Effects of a Six-Week Progressive Resistance Training Program on Functional Fitness among Community-Dwelling Older Adults

Received: 06 May 2020;  Published: 16 November 2020;  doi: 10.21926/obm.geriatr.2004138

Abstract

Research has indicated that older adult participation in resistance training provides foundational strength for performance of activities of daily living. The purpose of this study was to investigate the effects of a six-week progressive resistance training intervention on functional fitness among community-dwelling older adults. From 2010–2015, twelve sessions of a six-week resistance training intervention included 95 community-dwelling older adult participants (37 male, 58 female; Mage=73.5+7.2). Resistance [...]

1824 9894

Open Access Research Article

Feasibility of an 8-week Yoga Intervention among Middle-aged and Older Adults

Received: 13 August 2020;  Published: 06 November 2020;  doi: 10.21926/obm.geriatr.2004137

Abstract

Feasibility studies play a critical role in determining whether the target population is likely to engage with larger scale efficacy and effectiveness trials. Feasibility data for yoga interventions designed and conducted with older adults is limited. In this paper we present feasibility and acceptability data from an 8-week randomized controlled trial (RCT) conducted with middle aged and older adults. Participants n=118 (Mean age: 62.0 years) were randomized to either a Hatha yoga or Stretching Control group with [...]

1612 10881

Open Access Review

Aspiration Pneumonia and the Traditional Chinese Medicine Banxia Houpu Tang

Received: 24 August 2020;  Published: 27 October 2020;  doi: 10.21926/obm.geriatr.2004136

Abstract

Aspiration pneumonia is one of the most common reasons for death in stroke patients. Recently, a traditional herbal medicine banxia houpu tang is remarked to prevent the aspiration pneumonia. This review tells the history of study of banxia houpu tang for prevent aspiration pneumonia.

2473 11463

Open Access Research Article

Yoga to Reduce Leisure Constraints for Residents of Assisted Living Facilities

Received: 19 August 2020;  Published: 20 October 2020;  doi: 10.21926/obm.geriatr.2004135

Abstract

Residents of assisted living facilities face leisure constraints (barriers to leisure activities) at higher rates than their community-dwelling peers. Past research suggests yoga may be an effective intervention to decrease leisure constraints to physical activity. Therefore, the purpose of this study was to evaluate the impact of an eight-week yoga intervention on the leisure constraints of residents of assisted living facilities. The study employed a convergent mixed methods design to assess the impact of a 50-mi [...]

1766 10816

Open Access Research Article

What Makes Us Walk: Predictors and the Interplay of Physical and Cognitive Factors on Gait Speed in Community Dwelling Older Adults

Received: 03 April 2020;  Published: 27 September 2020;  doi: 10.21926/obm.geriatr.2003134

Abstract

This study investigated the predictors of gait speed in community dwelling older adults while examining interplay between physical performance and cognition on comfortable and fast gait speed. Sixty-six community-dwelling older adults (mean age 80.8 71% female) completed the following: 30-Second Chair Stand (30-SCS), Functional Reach (FR), Flanker Task, Digit Symbol Substitution Test (DSST), and gait speed (comfortable and fast). Hierarchical linear regression examined the relationship of comfortable and fast gait [...]

2024 9449

Open Access Review

Physical Activity’s Impact on Quality of Life in Older Adults with Dementia: A Systematic Review

Received: 04 June 2020;  Published: 23 September 2020;  doi: 10.21926/obm.geriatr.2003133

Abstract

Individuals with dementia frequently report poor quality of life (QOL), which declines as their disease progresses. Some evidence suggests that physical activity may help maintain cognitive function in older age, but it is unclear whether physical activity affects quality of life in older adults with dementia. The purpose of this review paper is to explore whether and how physical activity impacts QOL in patients with diagnosed dementia in different residential settings. To conduct this systematic review, the follo [...]

1454 12717

Open Access Editorial

Immune Senescence and Covid-19 Pandemic

Received: 05 September 2020;  Published: 10 September 2020;  doi: 10.21926/obm.geriatr.2003132

Abstract

Covid-19 pandemic has been infecting a substantial portion of the world population, thereby revealing quality deficits in health care in the majority of the countries around the globe. Severe illness and mortality from Covid-19 infection are present predominantly in minorities; especially they are more frequent in geriatric patients. Unfortunately, our knowledge is limited about what accounts for the variability in immune response from one person to another. This question is far from being merely academic, and find [...]

1630 7965

Open Access Research Article

Parkinson’s Disease Motor and Non-Motor Features Accompanying Insomnia and Excessive Daytime Sleepiness Symptoms, a Large Population-Based Study

Received: 30 June 2020;  Published: 26 August 2020;  doi: 10.21926/obm.geriatr.2003131

Abstract

Insomnia and excessive daytime sleepiness are the most common sleep disturbances in Parkinson’s disease. This study aims at better understanding how severity of PD motor and non-motor features and dopaminergic treatments contribute to these sleep symptoms in the first decade of PD. Data from a community-based cohort of PD patients was used to model cross-sectional PD-related risk factors for insomnia and EDS sleep scores using linear regression models adjusted for age, gender, and PD duration. Longitudinal changes [...]

1580 9472

Open Access Editorial

Driving Skills in Older Adults

Received: 11 August 2020;  Published: 19 August 2020;  doi: 10.21926/obm.geriatr.2003130

1296 7348

Open Access Research Article

Establishing a Method for Quantifying Spinal Curvature during Videofluoroscopic Swallow Studies: Applying the Modified Cobb Angle to Healthy Young and Older Adults

Received: 02 June 2020;  Published: 29 July 2020;  doi: 10.21926/obm.geriatr.2003129

Abstract

The Cobb angle is traditionally used for quantifying the degree of spinal curvature through evaluation of the full spinal cord. When conducting measurements on videofluoroscopy swallowing studies (VFSS), the Cobb angle can measure degree of cervical vertebrae curvature, which may have implications for swallowing. Given that this measure may have utility in dysphagia research, the reliability of this measure taken from C2-C4 and establishing the presence of changes with age were the focus of the current, proof-of-pr [...]

1980 11373

Open Access Review

A Delirium Monitoring Program for Hospitalized Older Adults: An Approach to Age-Friendly Health Systems

Received: 05 May 2020;  Published: 13 July 2020;  doi: 10.21926/obm.geriatr.2003128

Abstract

Delirium is an acute change in mental status with key features of inattention and disorganized thinking. It is particularly common in older adults, with multiple and varied causes. Delirium increases the risk of morbidity, mortality, institutionalization, and healthcare costs; however, it is often missed because it is difficult to recognize without the use of a validated screening tool. The Age-Friendly Health Systems (AFHS) initiative highlights the need for implementation of a delirium monitoring program in hospi [...]

2129 15067

Open Access Review

Ageing, Comorbidity and Frailty-Synergistic Risk Factors for Covid-19 Adverse Outcomes

Received: 31 May 2020;  Published: 10 July 2020;  doi: 10.21926/obm.geriatr.2003127

Abstract

With life-expectancy rising globally, the prevalence of ageing, comorbidity and frailty is likely to increase especially in the low and middle income countries. The emergence of the new COVID-19 pandemic has been concentrated in this group of patients and has led to worse outcomes compared to younger and less comorbid populations. This group of patients is at an increased risk of multi-organ consequences of systemic disease. Therefore, systemic assessment of these patients from the outset and optimisation of their [...]

1882 12308

Open Access Original Research

Bone Mineral Density in Male Hospital Physicians over the Age of 65 Years

Received: 01 April 2020;  Published: 02 July 2020;  doi: 10.21926/obm.geriatr.2003126

Abstract

Hospitalists are at risk for vitamin D deficiency during their active years due to indoor working conditions and insufficient sunlight exposure. The impairment of bone mineral density (BMD) in this group has not been studied. A total of 50 male hospitalists aged ≥ 65 years were enrolled. Their BMD was measured at the femoral neck (FN), lumbar spine (LS), and distal radius (DR), and their medical history and risk factors were assessed through a detailed questionnaire. The FRAX® (Fracture risk assessment tool) [...]

1626 8382

Open Access Original Research

The Effect of Live Bedside Music on Pain in Elderly Surgical Patients. A Unique Collaboration

Received: 08 April 2020;  Published: 01 July 2020;  doi: 10.21926/obm.geriatr.2003125

Abstract

Postoperative pain has a negative influence on physical and mental recovery and may result in a variety of postoperative complications. Listening to recorded music has been revealed to reduce pain, but in addition to that, live bedside music further offers the possibility to interact with the patient, respond to their emotions, and help them in adapting their conditions. It, therefore, seems appropriate for older surgical patients. This study examines the effect of live bedside music on postoperative elderly patien [...]

1550 9989

Open Access Original Research

On the Face of It: Social Heuristics Are Mediated by Age and Sex, But Not by Faciometrics

Received: 16 February 2020;  Published: 23 June 2020;  doi: 10.21926/obm.geriatr.2002124

Abstract

The ability to situate individuals within social categories provides an important social function, allowing people to navigate problems of survival and reproduction within highly complex social structures. This categorization of people with apparently shared characteristics is facilitated by various cues, one of the most important being facial information. There has been a wealth of literature that reports on perceptions of characteristics informed by faciometrics (or the measurement of facial features and associat [...]

1707 9106

Open Access Review

Bone Health in the Elderly with Type 2 Diabetes Mellitus–A Systematic Review

Received: 02 April 2020;  Published: 18 June 2020;  doi: 10.21926/obm.geriatr.2002123

Abstract

Type 2 diabetes mellitus (T2DM) and osteoporosis are two major public health concerns worldwide, contributing to morbidity and mortality in the elderly. Aging is one of the most significant risk factors for low bone mass, bone fragility, and fractures. Among the several comorbidities that affect the elderly with diabetes, increased fracture risk is a relatively recently discovered complication. Generally, individuals with T2DM exhibit higher bone mineral density, which complicates the assessment of fracture risk. D [...]

1720 12508

Open Access Research Article

Post-Mortem Comparison of the Incidence and the Distribution of Cerebrovascular Lesions Using Additional 7.0-Tesla Magnetic Resonance Imaging in Cognitive Normal Young, Middle-Aged, and Elderly Persons

Received: 06 April 2020;  Published: 04 June 2020;  doi: 10.21926/obm.geriatr.2002122

Abstract

Regional brain atrophy and an escalation in vascular risk are associated to increasing age in normal cognitive healthy persons. The present post-mortem study compares the incidence of cerebrovascular lesions between young-aged, middle-aged, and elderly cognitive normal persons with additional 7.0-tesla MRI). The patients consisted of 10 young adults, 20 middle-aged adults, and 14 elderly ones. In addition to the macroscopic visible cerebrovascular lesions, a whole coronal section of a cerebral hemisphere was taken [...]

1465 9172

Open Access Review

Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action

Received: 15 March 2020;  Published: 01 June 2020;  doi: 10.21926/obm.geriatr.2002121

Abstract

Despite continuous efforts to combat neurodegenerative diseases, researchers have been unable to find an intervention that reverses degeneration and/or improves cognition in dementia or healthy aging. Therefore, it is considerably important to identify lifestyle factors that could potentially aid in healthy brain aging and prevent or delay neurodegenerative diseases. The emerging interest in the ancient practice of fasting has inclined researchers to study the physiological and behavioral effects of this practice. [...]

2364 32116

Open Access Research Article

Association between Very Low Dietary Protein Intake and Subsequent Falls in Community-Dwelling Older Adults in the United States

Received: 10 April 2020;  Published: 22 May 2020;  doi: 10.21926/obm.geriatr.2002120

Abstract

Poor nutrition is linked to frailty and both poor nutrition and frailty are recognized risk factors for falls. This study examined the association between dietary protein intake and subsequent reported falls in community-dwelling older Americans with a history of falls. Other nutritional, functional, and sociodemographic-related variables were also considered in our model. This was a retrospective analysis using data from the U.S. Health and Retirement Study (HRS) and Health Care and Nutrition Study (HCNS), both fu [...]

1354 68246

Open Access Research Article

Adoption of a Patient-Tailored Fall Prevention Program in Academic Health Systems: A Qualitative Study of Barriers and Facilitators

Received: 23 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.geriatr.2002119

Abstract

Falls represent a persistent and costly patient safety issue. Fall TIPS (Tailored Interventions for Patient Safety) is a patient-centered and clinical decision-supported, fall prevention program that has led to fewer falls and related injuries among hospitalized patients. We aimed to identify dominant facilitators and barriers to Fall TIPS adoption. This multisite qualitative study was conducted in 11 hospitals representing three academic health systems, where Fall TIPS had been implemented for at least one year. I [...]

2762 32922

Open Access Research Article

Towards Positive Aging: Links between Forgiveness and Health

Received: 05 December 2018;  Published: 12 May 2020;  doi: 10.21926/obm.geriatr.2002118

Abstract

Forgiveness may serve as an essential positive resource to help individuals cope emotionally with stressful events, ultimately influencing health. Examination of how individuals forgive within the context of close relationships can provide useful information about positive aging. In this study, we examine how the severity of a recent transgression committed by a spouse/partner or other close social relationship is associated with self-reported physical health among older adults. We also examine how state forgivenes [...]

1831 11523

Open Access Review

Glial Alterations in Aging and Alzheimer’s Disease: A Novel Basis to Understand, Prevent and Treat the Degenerative Process

Received: 18 December 2019;  Published: 09 May 2020;  doi: 10.21926/obm.geriatr.2002117

Abstract

Neurons, from the time of their birth until their death, are always accompanied by neuroglial cells, maintaining very close morphological and functional relationships among themselves. Classically three main neuroglial families have been considered within the central nervous system (CNS): astroglia, oligodendroglia, and microglia. However, using morphological and immuno-cytochemical criteria, several different types/subtypes of neuroglial cells have been identified, each exerting specific physiological and patholog [...]

1575 10122

Open Access Review

New Horizons in Alzheimer Research from Amyloid and Beyond

Received: 01 December 2019;  Published: 29 April 2020;  doi: 10.21926/obm.geriatr.2002116

Abstract

The Amyloid and Tau Hypothesis of Alzheimer’s disease once thought to be the key have shown marginal results but are bolstered by the recent revival of the Aducanumab study and some positive data on some anti-Tau drugs. It still behoves us to look at other mechanisms which include whole blood transfusions, an Epigenetic approach, a-derivative of a Parkinson's drug a low dose of an anti-epileptic drug, an antibiotic against P Gingivitis and many new approaches not directly involving Amyloid and Tau. Other newer appr [...]

2013 69041

Open Access Case Report

Intestinal Necrosis Due to Digoxin Intoxication

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

Abstract

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

1848 10824

Open Access Original Research

Using a Rocking Chair in the Care of People with Dementia: A Single-Case Research Study

Received: 09 November 2019;  Published: 07 April 2020;  doi: 10.21926/obm.geriatr.2002114

Abstract

The people with dementia experience a progressive loss of cognition, while more than 90% of them develop behavioral and psychological symptoms of dementia (BPSD). BPSD may result in physical injuries and psychological distress among people with dementia and their family/caregivers. First-line care strategies in dementia care should not unthinkingly involve pharmacological interventions to avert or reduce the behavior, and should rather consider the person and their unique requirements. Therefore, a combination of p [...]

2459 17878

Open Access Review

Management of Older People With Diabetes - A Focus On Mental Functions

Received: 05 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002113

Abstract

The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk factor and, at the same time, as a consequence of diabetes. To break the vicious circle of this complex reciprocal relationship between diabetes and mental dysfunction, early id [...]

1493 10290

Open Access Editorial

Geriatric Cardiac Diseases

Received: 20 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002112

1176 7891

Open Access Review

Known–Unknowns in Geriatric Cardiology

Received: 05 February 2020;  Published: 19 March 2020;  doi: 10.21926/obm.geriatr.2001111

Abstract

The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly pa­tients dealing with the prevention of arterial hypertension, bradycardic arrhythmias, atrial fibrillation, coronary artery syndromes, valve heart diseases, and heart failure. Progress in the field of medicine has rendered possible to treat lethal cardiac diseases in the [...]

1607 9424

Open Access Review

Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways

Received: 26 December 2019;  Published: 28 February 2020;  doi: 10.21926/obm.geriatr.2001110

Abstract

Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. These pathological cascades lead to neuronal Ca2+ increase, neurodegeneration, gradual cognitive/memory decline, and eventually Alzheimer's disease. In particular, more recent research indicates that chronic inflamm [...]

1461 9491

Open Access Review

Dysphagia and Oral Health in Older People

Received: 14 November 2019;  Published: 20 February 2020;  doi: 10.21926/obm.geriatr.2001109

Abstract

Dysphagia is a term that is used for the difficulty in moving liquid/food from mouth to the stomach. Dysphagia is very common in elders, which makes them susceptible to malnutrition, infection, institutionalization, and death. Consequently, it is categorized as a geriatric syndrome. Therefore, multidisciplinary teams need to work together to determine the correct etiology and implement an appropriate care plan. Oral care is crucial in managing dysphagia and dental hygienists and dentists serve as the key members. I [...]

2095 16585

Open Access Original Research

Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial

Received: 13 October 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001108

Abstract

The incidence of vascular diseases among caregivers of dementia patients is high, and one potential cause is the exacerbation of blood coagulability due to mental strain from caregiving. This study aimed to examine the effects of aerobic exercise on blood coagulability, from the perspective of improving the health of caregivers. Thirty-one healthy elderly caregivers, residing with patients suffering from Alzheimer’s-type dementia, were randomly divided into two groups. In the intervention group, moderate walk [...]

1390 10376

Open Access Short Review

Alzheimer's Disease: Parsing the Pathways Leading to the Disease Based on the Spirochete/Biofilm Hypothesis

Received: 30 December 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001107

Abstract

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. This current work will show putative and plausible individual pathways that were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta amyloid; this has been shown in v [...]

1467 9009

Open Access Review

Problems Associated with the Measurement of Neuropsychiatric Symptoms of Dementia

Received: 04 December 2019;  Published: 17 February 2020;  doi: 10.21926/obm.geriatr.2001106

Abstract

Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfortunately, these efforts are hindered by inconsistent operational definitions and measurement tools for numerous neuropsychiatric symptoms. This review examines agitation, aggression, restlessness, and rejection of care a [...]

1864 11727

Open Access Review

Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease

Received: 31 December 2019;  Published: 14 February 2020;  doi: 10.21926/obm.geriatr.2001105

Abstract

Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) emergent rhythmic activity integrates cellular and network properties of these underlying circuits; and (ii) alterations in rhythmic patterns reflect the functional impact of changes on the network induced by the pathophysiology of the [...]

1319 10277

Open Access Review

Behaviors of Persons with Dementia: A Review and New Perspective for Future Research

Received: 30 July 2019;  Published: 07 February 2020;  doi: 10.21926/obm.geriatr.2001104

Abstract

Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review considers the illness experience and the need for more research using self-report methodology with persons with dementia in order to address the current gaps within the behaviour literature. With three main objectives, this [...]

1753 15429

Open Access Perspective

Target Tau, not Amyloid, to Prevent and Treat Alzheimer’s Disease

Received: 27 November 2019;  Published: 04 February 2020;  doi: 10.21926/obm.geriatr.2001103

Abstract

In this article I wish to put the case for a change of emphasis in the approach to finding a prevention/treatment for Alzheimer’s disease from a focus on beta amyloid to one on tau. In particular, I make the case for aiming to prevent the spread of abnormal tau from the medial temporal lobe to widespread areas of association cortex that are anatomically linked to this critical region. I pose an analogy with cardiovascular disease in which the initiating pathology, lipid streaks, are left untreated until they are so [...]

1499 9211

Open Access Original Research

Views of Conventional Medicine and Integrative Medicine among Informal Dementia Caregivers and Healthcare Professionals in NW England

Received: 06 September 2019;  Published: 21 January 2020;  doi: 10.21926/obm.geriatr.2001102

Abstract

The urgent need for innovative approaches to dementia treatment that are acceptable, effective and affordable underlies this research. Growing evidence supports ‘integrative medicine’ as a potential treatment approach aligned with and including conventional medicine. However, success will depend on addressing barriers, recognising needs of diverse communities and involving people in co-creating desired interventions. The three aims of this study were to, 1) describe conventional allopathic medicine and integrative [...]

1549 12620

Open Access Book Review

Review of: Forgotten: Narratives of Age-Related Dementia and Alzheimer’s Disease in Canada. By Marlene Goldman. McGill-Queen’s Press, 2017

Received: 05 November 2019;  Published: 17 January 2020;  doi: 10.21926/obm.geriatr.2001101

Abstract

none

1124 7294

Open Access Highlight

A Unified Model of Age-Related Disease

Received: 14 January 2020;  Published: 15 January 2020;  doi: 10.21926/obm.geriatr.2001100

Abstract

none

1272 13312

Open Access Case Report

Implications of Clozapine Complications in Geriatric Patients with Type II Diabetes Mellitus

Received: 14 October 2019;  Published: 10 January 2020;  doi: 10.21926/obm.geriatr.2001099

Abstract

Second-generation antipsychotics, have known metabolic side effects; specifically, clozapine is implicated in worsening or causing hyperglycemia, hypercholesterolemia and weight gain. Recently, there has been an increased interest in the safe use of clozapine in patients with diabetes. In March 2018, a 65-year-old female with a diagnosis of schizophrenia was admitted for inpatient hospitalization to a psychiatric hospital in Buffalo, NY for further stabilization after receiving two months of treatment at a comprehe [...]

1455 10887

Open Access Original Research

Using Mixed Methods to Explore Older Residents' Physical Activity and Experiences of Community Active Aging Friendliness

Received: 29 October 2018;  Published: 06 January 2020;  doi: 10.21926/obm.geriatr.2001098

Abstract

Physical inactivity is the fourth leading risk factor for global mortality and as such, it is critical that physical activity guidelines for health consider equitable access to physical activity opportunities for all, including those aged 65 years and older. The purpose of this study was to examine the intersections of attributes of older people (e.g. income, gender, age, health, physical activity) and attributes of the places they live (e.g. rurality, public transit, sidewalks, parks, community centre) to explain [...]

1471 9463

Open Access Research Article

A Novel Approach to Fall Risk Reduction: Combining Education and Therapeutic Yoga

Received: 03 October 2019;  Published: 03 January 2020;  doi: 10.21926/obm.geriatr.2001097

Abstract

Falls have negative consequences for older adults, but falls can be reduced through interventions that target the reduction of fall risk factors. Cognitive behavioral education programs and therapeutic yoga are two interventions that have independently been used as a means to reduce the risk of falls. The purpose of this study was to determine if adding therapeutic yoga following an education intervention improved well known fall risk factors. Potential participants were recruited through a senior center for a 12-w [...]

1863 10521

Open Access Review

Social Connectedness in Preventing Suicide among Older Adults

Received: 30 August 2019;  Published: 02 January 2020;  doi: 10.21926/obm.geriatr.2001096

Abstract

Social isolation and social disconnectedness have resulted in some older adults ending their lives by suicide; therefore, improving social connectedness has become an integral part of suicide prevention programmes. The purpose of this literature review was to assess the impact of social connectedness interventions for preventing suicide in older adults. It is evident that interventions aimed at promoting social connectedness are intended to alleviate stress and depressive symptoms due to social separation and traum [...]

2085 12251

Open Access Review

Design Guidelines to Reduce Extrinsic Fall Risks in the Built Environment

Received: 28 August 2019;  Published: 16 December 2019;  doi: 10.21926/obm.geriatr.1904095

Abstract

As people age, environments supporting changing needs can potentially impact their quality of life. Aging often leads to a decrease in the ability of people to interpret sensory cues within their environment. Using Pastalan's Empathic Model as a framework, a list of guidelines for the physical environment was established to address the extrinsic risk factors affecting falls. Attention to these items may not prevent all falls but will mitigate some of the external risks that cause falls for older adults. It is the g [...]

1559 12352

Open Access Original Research

Successful Aging and Positive Psychology: Two Empirically Related Perspectives

Received: 19 June 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904094

Abstract

Background: In the last two decades, successful aging (SA) and positive psychology (PP), the two paradigms of health have received great attention. They originate from different approaches, theoretical background, and objectives. Although they share many characteristics, their association remains understudied. This article aims to empirically analyze their possible interrelation. Methods: In this cross-sectional study, 169 healthy, old adults completed several questionnaires to assess the central framework for succ [...]

2240 16743

Open Access Original Research

Women’s Perceptions of the Embodied Experience of Osteoporosis across the Lifecourse

Received: 29 October 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904093

Abstract

Beliefs about the daily experience of a disease are used to identify risk and motivate participation in prevention. For osteoporosis, a disease that is affected by health behaviours throughout the lifecourse, individual perceptions of the disease can affect health decisions and future disease prevalence. Understanding how the experience of osteoporosis is perceived by women at different stages of life can illuminate factors that influence engagement in prevention. Women representing three life stages - young adults [...]

1270 8591

Open Access Original Research

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.geriatr.1904092

Abstract

Background: Studies conducted on the effectiveness of psychosocial interventions have indicated that sensory stimulation represents a promising approach to reduce the psychological and behavioral disturbances in people with dementia. Multi-sensory stimulation involves the simultaneous stimulation of multiple senses, through the use of various methods, for example, by using a variety of lights, gentle stimulating music, aromas, and tactile objects, among others. A relatively novel approach is the enriched thematic m [...]

2334 13524

Open Access Review

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Received: 06 August 2019;  Published: 04 December 2019;  doi: 10.21926/obm.geriatr.1904091

Abstract

The prevalence of Late-life Depression (LLD) has been estimated between 10% and 15%. Therefore, it is a considerable worldwide problem. The psychopathology is not substantially different from that of depressive episodes in young adults but somatic complaints in combination with end-of-life perspective leave an imprint on emotional experience. The frequent suicidal tendency, especially in old unmated men, remains a particular challenge. It is important to combine psychiatric and somatic diagnostics using modern meth [...]

1591 12080

Open Access Review

The Association between Bone Turnover Markers and Fracture in People with Diabetes: A Systematic Review and Meta-Analysis

Received: 29 August 2019;  Published: 04 December 2019;  doi: 10.21926/obm.geriatr.1904090

Abstract

Background: The increased risk of fractures in individuals with diabetes has been underestimated by conventional fracture predictors such as the bone mineral density T-score or the Fracture Risk Assessment Tool. The present study conducted a systematic review and a meta-analysis to investigate the association between the levels of bone turnover markers (BTMs) and fractures in patients with diabetes. Methods: We conducted a systematic literature search. Eligibility criteria were studies investigating BTMs in patient [...]

1297 9346

Open Access Original Research

Automated Movement Feedback for Recovering Independence in the Sit-to-Stand Movement in an Older Population: A Pilot Randomised Controlled Trial of a Novel System

Received: 23 September 2019;  Published: 02 December 2019;  doi: 10.21926/obm.geriatr.1904089

Abstract

Background: The sit-to-stand (StS) movement is a frequently performed task critical to independent living that is both difficult to perform and associated with falls in older populations. Consequently, the recovery of this movement through supervised practice is a priority during the rehabilitation of older people. Technology may enable self-practice, potentially improving rehabilitation outcomes. The purpose of this study was to evaluate the clinical feasibility and effectiveness of an automated movement feedback [...]

1795 11270

Open Access Case Report

Physical Illness and Emotional Expression in Late Life

Received: 14 August 2019;  Published: 25 November 2019;  doi: 10.21926/obm.geriatr.1904088

Abstract

Louise H., Ph.D was referred to me by her long-term primary care physician (PCP) who was certain that his patient was seriously depressed and in need of medication and possibly psychotherapy. My own assessment, in consultation with a neurologist, was that Louise’s problems with coping were primarily neurological, and that her issues were due to serious (and in one case embarrassing) symptoms. Her neurological problems (mild Parkinsonism and PseudoBulbar Affect, or PBA) are currently being addressed by the neurologi [...]

1237 8077

Open Access Research Article

Balance and Fall Rates are Associated with Chronic Pain, and Improve with Yoga

Received: 29 September 2019;  Published: 25 November 2019;  doi: 10.21926/obm.geriatr.1904087

Abstract

Background: Falls are relatively common in older adults and are associated with chronic pain. Chronic pain may even be a predictor of falls in older adults. However, this relationship has not been studied in adults

1647 9463

Open Access Original Research

Evaluation of the Prevalence of Screening for Dysphagia among Older People Admitted to Medical Services – An International Survey

Received: 15 September 2019;  Published: 15 November 2019;  doi: 10.21926/obm.geriatr.1904086

Abstract

Background: With the increasing age of the world population, the number of old and frail people is increasing. Respiratory disease is a common reason for hospital admission for older people. Aspiration of saliva, which is probably infected, is the likely etiological agent. The incidence of an abnormal swallow is high in frail older people. Despite the high incidence of swallow problems among older people, many hospital services do not routinely screen older people for dysphagia. Methods: A survey, using Research El [...]

2277 29341

Open Access Editorial

Fragility Fractures in the Elderly Osteoporotic Patient and the Efficacy of Fracture Liaison Service Programs

Received: 07 November 2019;  Published: 13 November 2019;  doi: 10.21926/obm.geriatr.1904085

Abstract

None.

1474 8826

Open Access Case Report

Qualitative Evaluation of Interdisciplinary Service Learning Experience to Assess and Manage Fall Risk in Community-Dwelling Older Adults

Received: 15 August 2019;  Published: 29 October 2019;  doi: 10.21926/obm.geriatr.1904084

Abstract

Aim: The purpose of this study was to evaluate faculty and student perceptions of a fall risk assessment and prevention activity for older adults offered in multiple community settings by health professional faculty and students. Background: In the US, the percentage of adults 65 and older who fell was more than 29% in 2018. Among states, Arkansas ranks 48th with 35.2% of older adults reporting a fall (CDC Behavioral Risk Factor Surveillance System, 2018). Methods: Four senior centers in Northwest Arkansas hosted a [...]

1629 10401

Open Access Review

Ageing: The Role of Ageism

Received: 20 June 2019;  Published: 28 October 2019;  doi: 10.21926/obm.geriatr.1904083

Abstract

Worldwide, people are living longer but not necessarily experiencing optimal health since healthy ageing stems from a combination of biological, psychological, and social factors. The growing interdisciplinary literature on ageism from fields such as education, medicine, psychology, and social work increasingly highlights the pivotal role that ageism plays in ageing. Ageism is generally an overlooked factor in understanding and fostering healthy ageing. Ageism creates a negative view of the ageing process as marked [...]

4307 34599

Open Access Research Article

Using Health-Related Quality of Life (SF-36v2®) to Predict Falls in Community-Dwelling Older Adults

Received: 14 September 2019;  Published: 25 October 2019;  doi: 10.21926/obm.geriatr.1904082

Abstract

Background: Falls are the leading cause of hospitalization and death among older adults; therefore, the ability to predict fall risk among older adults is critical. Several performance-based outcome measures exist to assess fall risk. Psychological factors are also associated with fall risk yet can be difficult to assess and are often overlooked. In this study, we investigated whether the Short Form 36 Item Health Survey (SF-36v2®), a measure of health-related quality of life (HRQOL), predicted future falls in [...]

1566 10763

Open Access Concept Paper

Admiral Nursing in Primary Care: Peri and Post-Diagnostic Support for Families Affected by Dementia within the UK Primary Care Network Model

Received: 19 September 2019;  Published: 18 October 2019;  doi: 10.21926/obm.geriatr.1904081

Abstract

The population of the United Kingdom is ageing. In 2017 approximately 18% of the UK population were aged 65 years or over and projected to grow to almost 21% by 2027 according to the Office of National Statistics. Increased age is the greatest risk factor for developing dementia. It is estimated that there are 850,000 people living with dementia in the UK and if current figures relating to incidence and prevalence are realised, this will increase to 1 million people by 2025 and 2 million by 2051. The National Healt [...]

1664 14354

Open Access Original Research

Naming and Framing the Behavioural and Psychological Symptoms of Dementia (BPSD) Paradigm: Professional Stakeholder Perspectives

Received: 08 September 2019;  Published: 11 October 2019;  doi: 10.21926/obm.geriatr.1904080

Abstract

Background: Behavioural and Psychological Symptoms of Dementia and Challenging Behaviour in dementia are just two of a variety of terms for a complex paradigm that covers the most distressing and costly aspects of the condition. The terminology used to describe these aspects can influence what is measured as outcomes and what is considered as evidence of improvement. Unhelpful or outmoded narratives could be a barrier to developing innovative interventions or in determining what works for whom. This UK study explor [...]

2299 18939

Open Access Perspective

Behavioral versus Biological Definitions of Dementia Symptoms: Recognizing that Worthwhile Interventions already Exist

Received: 31 July 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904079

Abstract

Background: The 2018 Alzheimer's Disease Facts and Figures special report includes two new guidelines for measuring dementia symptoms. The first requires that a biomarker (biological factor) be added to a doctor's clinical judgment of the cause of symptoms when determining whether dementia is present. The second involves identifying four stages of dementia: normal cognition, preclinical, MCI and dementia. Now only those with defining brain pathologies and significant symptoms will be judged to be persons with stage [...]

2979 14222

Open Access Research Article

GAPcare: The Geriatric Acute and Post-Acute Fall Prevention Intervention for Emergency Department Patients – A Qualitative Evaluation

Received: 21 August 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904078

Abstract

Background: Three million US emergency department (ED) visits occur for falls each year. The mortality of falls is increasing and only one fourth of older adults report their fall to their primary care provider, suggesting that valuable preventative opportunities are missed. A fall prevention intervention initiated in the ED immediately after a fall has the potential to reduce subsequent falls, but ED providers lack the time and resources to complete fall risk assessments on their patients. GAPcare, the Geriatric A [...]

2944 14009

Open Access Review

Aging in A Changing World – the Impact of Social Contact and Physical Activity on Health-Related Quality among Older People from Austria – A Biological Perspective

Received: 23 June 2019;  Published: 08 October 2019;  doi: 10.21926/obm.geriatr.1904077

Abstract

Background: All over the world we are confronted with an absolute and relative increase in the proportion of older people. In order to develop strategies to keep older people healthy and independent as long as possible, analyses of factors influencing health related quality of life (HRQL) during old age are necessary. The aim of this review is to present the results of three projects carried out in Austria by the author focusing on the impact of social contact and physical activity on HRQL. Methods: The standardize [...]

1590 10091

Open Access Concept Paper

The “PRIMING, TIMING, MIMING” Model of Individualized Behavioural Care Planning for Residents with Dementia

Received: 30 July 2019;  Published: 29 September 2019;  doi: 10.21926/obm.geriatr.1903076

Abstract

The current paper introduces the “Priming/Timing/Miming” Model of Behavioural Care Planning for persons with Dementia. This simple heuristic provides a quick, easy and systematic way to select from the vast number of behavioural strategies offered in the BPSD literature and to organize these in a way that can be incorporated into an individualized Behaviour Care Plan to deliver personal care to persons with dementia and also to develop a larger plan of care. An entire care plan is captured on one double-sided sheet [...]

1622 13105

Open Access Original Research

Sleep Symptoms Differentially Predict Cognition in Younger and Older-Onset Parkinson's Disease

Received: 13 May 2019;  Published: 23 September 2019;  doi: 10.21926/obm.geriatr.1903075

Abstract

Background: Both disrupted sleep and cognitive impairment are frequent in Parkinson’s disease (PD), but the evidence for a relationship between self-reported sleep disturbance and cognitive symptoms has been equivocal. If sleep symptoms differentially predict cognition in different subtypes, effects may be obscured in a general PD sample. Objective: First, to determine whether the associations between participant and disease variables, sleep symptoms and cognitive performance vary by subtype (younger and olde [...]

1913 11314

Open Access Review

Management of Neuropsychiatric Symptoms of Dementia: A Comprehensive Review of the Current Literature

Received: 14 May 2019;  Published: 16 September 2019;  doi: 10.21926/obm.geriatr.1903074

Abstract

Background: Dementia is a progressive and debilitating condition that affects millions of patients in the United States with an enormous impact on healthcare costs, caregivers, and society. Patients with dementia often experience dementia-related neuropsychiatric disturbances, commonly known as Behavioral and Psychological Symptoms of Dementia (BPSD) and more recently Neuropsychiatric symptoms (NPS) in dementia. These symptoms include verbal and physical agitation, aggression, disinhibition, affect lability, apathy [...]

1775 13204

Open Access Review

Facilitation of Social Support through Negative Allosteric Modulation of α5-Associated GABAA Receptors: A Novel Mechanism for the Treatment of Depression, Agitation, and Aggression in the Elderly

Received: 05 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903073

Abstract

Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of α5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also [...]

1644 10557

Open Access Original Research

Wisdom of the Elders: Narratives Enhancing Trainees’ Attitudes Towards Aging

Received: 25 April 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903072

Abstract

Background: Narratives encompass written reflection experiences and hold the potential to display valuable insights into trainees’ thinking. We analyzed narratives from graduate students trained in aging themes, who then interviewed older hospitalized adults (senior partners) about their life experiences. Methods: Three Discovery & Learning Fellows trained on open-ended interviewing, empathy, and aging themes performed semi-structured interviews. Senior partners were hospitalized older veterans. After the [...]

1461 9285

Open Access Original Research

Atrial Fibrillation, Anticoagulation, and Major Bleeding Episodes in Geriatric Patients at the Risk of Falling

Received: 22 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903071

Abstract

Background: Geriatric patients are at risk of atrial fibrillation (AF) and stroke, and the risk of oral anticoagulation (OAC) related bleeding is also presumed to be higher. Detailed knowledge about the prevalence of AF and bleeding pattern in this population is scarce. This study sought to assess the prevalence of AF, use of OAC, and the rate of major bleeding in geriatric patients who are prone to frequent falls. We expect to find a higher prevalence of AF among geriatric patients compared to elderly people of co [...]

1421 9815

Open Access Review

Shedding Light on Manic Syndromes and Dementia

Received: 27 March 2019;  Published: 16 August 2019;  doi: 10.21926/obm.geriatr.1903070

Abstract

Background: Mania in older adults is associated with a high rate of medical and neurological disease. Objective: The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, late-onset, mania, and elderly. Publications found through this indexed search were reviewed for further relevant references. Resultsan [...]

1930 34488

Open Access Original Research

Intranasal Insulin in Alzheimer’s Disease: A Pragmatic Account

Received: 15 March 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903069

Abstract

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and early to moderate Alzheimer’s Disease (AD) in the domains of jokes, self-expression and empathy after extended, targeted intranasal insulin therapy. In this paper it is argued that extended intra-nasal insulin treatment can [...]

1784 10315

Open Access Review

The Value Given and Presupposed in Person-Centred Dementia Care

Received: 08 April 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903068

Abstract

Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the standing or status bestowed on one human being by others in the context of relationships and social being and held that respect for the absolute value of each person is a key theme in Western ethical discourse. He was clear thi [...]

2122 18474

Open Access Original Research

Differential Effects of Social Network on Health in Later Life and the Moderating Role of Depression

Received: 23 March 2019;  Published: 12 August 2019;  doi: 10.21926/obm.geriatr.1903067

Abstract

Background: Differential effects of the characteristics of social network on limitations with activities (LWA) and the quality of life (QOL) among older adults, and the moderating role of depression were studied. Methods: The data obtained from two consecutive waves of the Survey of Health, Aging, and Retirement in Europe (SHARE) was examined. Results: Emotional closeness, satisfaction with the social network, and contact frequency were able to predict the QOL and not LWA. Moreover, depression was observed to moder [...]

1403 10546

Open Access Case Report

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Received: 08 April 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903066

Abstract

The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a ‘personalised medicine’ approach challenges this view. This paper reviews the current evidence for dementia prevention utilising such treatments and explains the logic of applying personalised medicine. The functional medicine treatment approach to ‘root cause’ analysis is presented as currently practiced with patients experiencing cognitive [...]

2455 30760

Open Access Review

A Model for Understanding Hispanic/Latino Family Caregiving for Older Adults

Received: 19 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903065

Abstract

Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families for care. Methods: Review published caregiving models for older adults in H/L populations. Results: Gradual and inevitable acculturation of H/L caregivers to U.S. social customs, and the mutual relationship within the [...]

1613 12706

Open Access Review

Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5

Received: 05 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.geriatr.1903064

Abstract

The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided much understanding of molecular and cellular biology, as well as insights into many human diseases. In this paper we review how yeast studies are contributing to knowledge about the role of oxidative damage to cell health, and how one of the key players in Alzheimer’s disease, amyloid beta (Aβ) is linked to the reactive oxygen species response involving AHP1, which encodes an alkyl hydroperoxidase, Ahp1p, a protein involved in protect [...]

1742 9475

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Received: 12 June 2019;  Published: 16 July 2019;  doi: 10.21926/obm.geriatr.1903063

Abstract

Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a century of pharmacological failures in stopping or slowing the disease, there is a need to examine how the simplified cause evolved and to explore alternate approaches to understanding Alzheimer’s disease. Going beyond the nar [...]

1807 9610

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Received: 28 March 2019;  Published: 15 July 2019;  doi: 10.21926/obm.geriatr.1903062

Abstract

Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia benefit from reduction of their non-cognitive, behavioural changes, enhancement of their cognitive capacities and being socially active. Methods: The current study represents a narrative general literature review on availabl [...]

2146 17260

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Received: 19 February 2019;  Published: 09 July 2019;  doi: 10.21926/obm.geriatr.1903061

Abstract

Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on short notice and in emergencies. Methods: This study used city government survey results on service user satisfaction with the Japanese Long-Term Care Insurance (LTCI) system for a mid-sized, Japanese city. From this a range [...]

1628 13366

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Received: 30 March 2019;  Published: 08 July 2019;  doi: 10.21926/obm.geriatr.1903060

Abstract

The understanding of mental deterioration associated with old age has undergone several changes over the past two centuries, and has spurred major scientific debates. In the 19th century, this disorder was still considered an inevitable part of aging. The beginning of the 20th century offered a histological explanation for presenile dementia, and Alois Alzheimer was credited as the discoverer of a new disease that bears his name to date. In the last quarter of the 20th century, findings of Alois Alzheimer were appl [...]

1523 10171

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Received: 20 August 2018;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902059

Abstract

Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) from VR scenes has not been adequately investigated. During this study, we used a novel rotating visual scene to study the effects of aging, prior experience with VR, and dementia on the accuracy of encoding categorical [...]

1578 9541

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Received: 31 January 2019;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902058

Abstract

Background: Quality or healthy aging refers to well-being in an older age. In the light of recent changes in the discourse on approaches on positive aging, we aimed to study the way “quality aging” is understood, expressed, and dealt with as a part of contemporary technology assessment (TA), since the nexus between demographic and technological changes has remained a staple topic in TA for at least three decades. Methods: A bottom-up qualitative content analysis was performed to identify the concepts of [...]

1910 11419

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Abstract

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

1555 9386

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Received: 20 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902056

Abstract

Alzheimer’s Disease is increasingly seen as the major health problem in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The pervasiveness of this view can mean that other perspectives and even the views of those most touched by the challenges of dementia remain unheard. Part of the cultural conversation around dementia is informed by [...]

1475 8104

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Received: 29 January 2019;  Published: 24 May 2019;  doi: 10.21926/obm.geriatr.1902055

Abstract

The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Respect for the autonomy of older persons is highlighted as a cornerstone of care by medical professionals and family members. There remains the challenge, however, of caring for older people who do not have full decision-making cap [...]

2905 36013

Open Access Original Research

Empirical Examination of Caregiving Processes and Outcomes among Adult Siblings of Individuals with Intellectual and Developmental Disabilities

Received: 25 February 2019;  Published: 20 May 2019;  doi: 10.21926/obm.geriatr.1902054

Abstract

Background: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. Methods: In this study, we examined caregiving processes and outcomes among 322 adult sibling support providers (SSPs) with a range of support roles. Adapting a model of caregiving outcomes, we used structural equation modeling to assess relationships amo [...]

1541 10471

Open Access Review

Admiral Nurse Case Management: A Model of Caregiver Support for Families Affected by Dementia

Received: 26 February 2019;  Published: 10 May 2019;  doi: 10.21926/obm.geriatr.1902053

Abstract

There has been a strong thrust to identify the needs of people with dementia against a background of person-centred care, however, people with dementia do not exist in isolation; they live within relational contexts with family members. Case management is a model of care that has its origins in supporting patients with a long term disease, however, a very practical approach to case management that can support the care needs of both the person with dementia and the family carers is emerging in the UK. Admiral Nursin [...]

2182 17233

Open Access Research Article

The Relationship between Caregiver Stress and Behavioural Changes in Dementia

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Abstract

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston Standardized Cognitive Asse [...]

2177 12781

Open Access Concept Paper

Biological Age versus Chronological Age in the Prevention of Age Associated Diseases

Received: 31 January 2019;  Published: 05 May 2019;  doi: 10.21926/obm.geriatr.1902051

Abstract

Aging is associated with an increased incidence of major diseases, including cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome, quality of life and are commonly applied as age-dependent indications based on evidence of efficacy for specific groups of the aging population. They likely contribute to the observed increase in life expectancy through the reduction of incidence and the retarda [...]

2353 16802

Open Access Project Report

An Evaluation of a Community-Based Psychoeducation Program for Successful Ageing

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

Abstract

Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their outcomes is essential. This study used mixed methods to evaluate cognitive and behavioural changes and to monitor psychological health and active ageing in participants of a longstanding positive ageing psycho [...]

1561 11428

Open Access Original Research

Moderators of Treatment Outcomes from Family Caregiver Skills Training: Secondary Analysis of a Randomized Controlled Trial

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Abstract

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

1926 10988

Open Access Case Report

Daily Observations of Preserved Cognition and Quality of Life after Multiple Therapies for Postmortem-Verified Severe Alzheimer’s

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Abstract

Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows significant preservation of cognition and quality of life in the daily routine of a woman with severe Alzheimer’s who was given multiple therapeutic interventions. Alzheimer’s disease involves multiple d [...]

1374 9270

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

Abstract

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

1617 11069

Open Access Review

Engagement and Utilization of Advance Care Planning and Hospice in Different Older Asian American Populations

Received: 31 October 2018;  Published: 08 April 2019;  doi: 10.21926/obm.geriatr.1902046

Abstract

This research review sought to examine the patterns of engagement in advance care planning (ACP) and utilization of end-of-life (EoL) care treatment services including, but not limited to hospice care, in distinct older Asian American ethnic groups. The review of existing research suggested evidence that empirical studies about different older subpopulations of Asian Americans remains scarce. This research analysed 30 small-scale studies on older Asian Americans’ attitudes and engagement in EoL care planning. The r [...]

1995 14278

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