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Table of Content

Open Access Review

Intermittent Fasting and Brain Health: Efficacy and Potential Mechanisms of Action

Received: 15 March 2020;  Published: 01 June 2020;  doi: 10.21926/obm.geriatr.2002121

Abstract

Despite continuous efforts to combat neurodegenerative diseases, researchers have been unable to find an intervention that reverses degeneration and/or improves cognition in dementia or healthy aging. Therefore, it is considerably important to identify lifestyle factors that could potentially aid in healthy brain aging and prevent or delay neurodegenerative diseases. The emerging interest in the ancient practice of fasting has inclined researchers to study the physiological and behavioral effects of this practice. [...]

2292 31388

Open Access Research Article

Association between Very Low Dietary Protein Intake and Subsequent Falls in Community-Dwelling Older Adults in the United States

Received: 10 April 2020;  Published: 22 May 2020;  doi: 10.21926/obm.geriatr.2002120

Abstract

Poor nutrition is linked to frailty and both poor nutrition and frailty are recognized risk factors for falls. This study examined the association between dietary protein intake and subsequent reported falls in community-dwelling older Americans with a history of falls. Other nutritional, functional, and sociodemographic-related variables were also considered in our model. This was a retrospective analysis using data from the U.S. Health and Retirement Study (HRS) and Health Care and Nutrition Study (HCNS), both fu [...]

1248 67895

Open Access Research Article

Adoption of a Patient-Tailored Fall Prevention Program in Academic Health Systems: A Qualitative Study of Barriers and Facilitators

Received: 23 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.geriatr.2002119

Abstract

Falls represent a persistent and costly patient safety issue. Fall TIPS (Tailored Interventions for Patient Safety) is a patient-centered and clinical decision-supported, fall prevention program that has led to fewer falls and related injuries among hospitalized patients. We aimed to identify dominant facilitators and barriers to Fall TIPS adoption. This multisite qualitative study was conducted in 11 hospitals representing three academic health systems, where Fall TIPS had been implemented for at least one year. I [...]

2655 32193

Open Access Research Article

Towards Positive Aging: Links between Forgiveness and Health

Received: 05 December 2018;  Published: 12 May 2020;  doi: 10.21926/obm.geriatr.2002118

Abstract

Forgiveness may serve as an essential positive resource to help individuals cope emotionally with stressful events, ultimately influencing health. Examination of how individuals forgive within the context of close relationships can provide useful information about positive aging. In this study, we examine how the severity of a recent transgression committed by a spouse/partner or other close social relationship is associated with self-reported physical health among older adults. We also examine how state forgivenes [...]

1788 11348

Open Access Review

Glial Alterations in Aging and Alzheimer’s Disease: A Novel Basis to Understand, Prevent and Treat the Degenerative Process

Received: 18 December 2019;  Published: 09 May 2020;  doi: 10.21926/obm.geriatr.2002117

Abstract

Neurons, from the time of their birth until their death, are always accompanied by neuroglial cells, maintaining very close morphological and functional relationships among themselves. Classically three main neuroglial families have been considered within the central nervous system (CNS): astroglia, oligodendroglia, and microglia. However, using morphological and immuno-cytochemical criteria, several different types/subtypes of neuroglial cells have been identified, each exerting specific physiological and patholog [...]

1497 9885

Open Access Review

New Horizons in Alzheimer Research from Amyloid and Beyond

Received: 01 December 2019;  Published: 29 April 2020;  doi: 10.21926/obm.geriatr.2002116

Abstract

The Amyloid and Tau Hypothesis of Alzheimer’s disease once thought to be the key have shown marginal results but are bolstered by the recent revival of the Aducanumab study and some positive data on some anti-Tau drugs. It still behoves us to look at other mechanisms which include whole blood transfusions, an Epigenetic approach, a-derivative of a Parkinson's drug a low dose of an anti-epileptic drug, an antibiotic against P Gingivitis and many new approaches not directly involving Amyloid and Tau. Other newer appr [...]

1923 68812

Open Access Case Report

Intestinal Necrosis Due to Digoxin Intoxication

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

Abstract

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

1738 10598

Open Access Original Research

Using a Rocking Chair in the Care of People with Dementia: A Single-Case Research Study

Received: 09 November 2019;  Published: 07 April 2020;  doi: 10.21926/obm.geriatr.2002114

Abstract

The people with dementia experience a progressive loss of cognition, while more than 90% of them develop behavioral and psychological symptoms of dementia (BPSD). BPSD may result in physical injuries and psychological distress among people with dementia and their family/caregivers. First-line care strategies in dementia care should not unthinkingly involve pharmacological interventions to avert or reduce the behavior, and should rather consider the person and their unique requirements. Therefore, a combination of p [...]

2338 17401

Open Access Review

Management of Older People With Diabetes - A Focus On Mental Functions

Received: 05 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002113

Abstract

The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk factor and, at the same time, as a consequence of diabetes. To break the vicious circle of this complex reciprocal relationship between diabetes and mental dysfunction, early id [...]

1421 9912

Open Access Editorial

Geriatric Cardiac Diseases

Received: 20 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002112

1114 7729

Open Access Review

Known–Unknowns in Geriatric Cardiology

Received: 05 February 2020;  Published: 19 March 2020;  doi: 10.21926/obm.geriatr.2001111

Abstract

The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly pa­tients dealing with the prevention of arterial hypertension, bradycardic arrhythmias, atrial fibrillation, coronary artery syndromes, valve heart diseases, and heart failure. Progress in the field of medicine has rendered possible to treat lethal cardiac diseases in the [...]

1521 9209

Open Access Review

Biomaterial to Improve Drug Delivery in Alzheimer's Disease: Linking Major Pathogenic Pathways

Received: 26 December 2019;  Published: 28 February 2020;  doi: 10.21926/obm.geriatr.2001110

Abstract

Aging, hypertension, diabetes, obesity, atherosclerosis, traumatic brain injury, and other factors can all synergistically promote diverse pathological mechanisms. These risk factors trigger widespread inflammation and oxidative stress, both of which can lead to blood-brain barrier (BBB) disruption. These pathological cascades lead to neuronal Ca2+ increase, neurodegeneration, gradual cognitive/memory decline, and eventually Alzheimer's disease. In particular, more recent research indicates that chronic inflamm [...]

1370 9299

Open Access Review

Dysphagia and Oral Health in Older People

Received: 14 November 2019;  Published: 20 February 2020;  doi: 10.21926/obm.geriatr.2001109

Abstract

Dysphagia is a term that is used for the difficulty in moving liquid/food from mouth to the stomach. Dysphagia is very common in elders, which makes them susceptible to malnutrition, infection, institutionalization, and death. Consequently, it is categorized as a geriatric syndrome. Therefore, multidisciplinary teams need to work together to determine the correct etiology and implement an appropriate care plan. Oral care is crucial in managing dysphagia and dental hygienists and dentists serve as the key members. I [...]

2006 16223

Open Access Original Research

Exploring the Effects of Aerobic Exercise on Blood Coagulability in Caregivers of Patients with Dementia: A Randomized Controlled Trial

Received: 13 October 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001108

Abstract

The incidence of vascular diseases among caregivers of dementia patients is high, and one potential cause is the exacerbation of blood coagulability due to mental strain from caregiving. This study aimed to examine the effects of aerobic exercise on blood coagulability, from the perspective of improving the health of caregivers. Thirty-one healthy elderly caregivers, residing with patients suffering from Alzheimer’s-type dementia, were randomly divided into two groups. In the intervention group, moderate walk [...]

1319 10194

Open Access Short Review

Alzheimer's Disease: Parsing the Pathways Leading to the Disease Based on the Spirochete/Biofilm Hypothesis

Received: 30 December 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001107

Abstract

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. This current work will show putative and plausible individual pathways that were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta amyloid; this has been shown in v [...]

1402 8825

Open Access Review

Problems Associated with the Measurement of Neuropsychiatric Symptoms of Dementia

Received: 04 December 2019;  Published: 17 February 2020;  doi: 10.21926/obm.geriatr.2001106

Abstract

Neuropsychiatric symptoms (NPS) affect nearly all persons living with dementia (PLWD) at some point during the course of the disease. Given the absence of a cure or effective pharmacotherapy for dementia, it is particularly important to prevent, measure, track, and manage NPS in dementia care. Unfortunately, these efforts are hindered by inconsistent operational definitions and measurement tools for numerous neuropsychiatric symptoms. This review examines agitation, aggression, restlessness, and rejection of care a [...]

1776 11467

Open Access Review

Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s Disease

Received: 31 December 2019;  Published: 14 February 2020;  doi: 10.21926/obm.geriatr.2001105

Abstract

Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) emergent rhythmic activity integrates cellular and network properties of these underlying circuits; and (ii) alterations in rhythmic patterns reflect the functional impact of changes on the network induced by the pathophysiology of the [...]

1227 10039

Open Access Review

Behaviors of Persons with Dementia: A Review and New Perspective for Future Research

Received: 30 July 2019;  Published: 07 February 2020;  doi: 10.21926/obm.geriatr.2001104

Abstract

Through the assessment of previous and current literature on the behaviors experienced by persons with dementia, this review discusses the terminology, conceptual models, measurement techniques, and non-pharmacological interventions employed within behavioral research. Additionally, this review considers the illness experience and the need for more research using self-report methodology with persons with dementia in order to address the current gaps within the behaviour literature. With three main objectives, this [...]

1693 15031

Open Access Perspective

Target Tau, not Amyloid, to Prevent and Treat Alzheimer’s Disease

Received: 27 November 2019;  Published: 04 February 2020;  doi: 10.21926/obm.geriatr.2001103

Abstract

In this article I wish to put the case for a change of emphasis in the approach to finding a prevention/treatment for Alzheimer’s disease from a focus on beta amyloid to one on tau. In particular, I make the case for aiming to prevent the spread of abnormal tau from the medial temporal lobe to widespread areas of association cortex that are anatomically linked to this critical region. I pose an analogy with cardiovascular disease in which the initiating pathology, lipid streaks, are left untreated until they are so [...]

1396 9025

Open Access Original Research

Views of Conventional Medicine and Integrative Medicine among Informal Dementia Caregivers and Healthcare Professionals in NW England

Received: 06 September 2019;  Published: 21 January 2020;  doi: 10.21926/obm.geriatr.2001102

Abstract

The urgent need for innovative approaches to dementia treatment that are acceptable, effective and affordable underlies this research. Growing evidence supports ‘integrative medicine’ as a potential treatment approach aligned with and including conventional medicine. However, success will depend on addressing barriers, recognising needs of diverse communities and involving people in co-creating desired interventions. The three aims of this study were to, 1) describe conventional allopathic medicine and integrative [...]

1477 12424

Open Access Book Review

Review of: Forgotten: Narratives of Age-Related Dementia and Alzheimer’s Disease in Canada. By Marlene Goldman. McGill-Queen’s Press, 2017

Received: 05 November 2019;  Published: 17 January 2020;  doi: 10.21926/obm.geriatr.2001101

Abstract

none

1058 7155

Open Access Highlight

A Unified Model of Age-Related Disease

Received: 14 January 2020;  Published: 15 January 2020;  doi: 10.21926/obm.geriatr.2001100

Abstract

none

1221 13117

Open Access Case Report

Implications of Clozapine Complications in Geriatric Patients with Type II Diabetes Mellitus

Received: 14 October 2019;  Published: 10 January 2020;  doi: 10.21926/obm.geriatr.2001099

Abstract

Second-generation antipsychotics, have known metabolic side effects; specifically, clozapine is implicated in worsening or causing hyperglycemia, hypercholesterolemia and weight gain. Recently, there has been an increased interest in the safe use of clozapine in patients with diabetes. In March 2018, a 65-year-old female with a diagnosis of schizophrenia was admitted for inpatient hospitalization to a psychiatric hospital in Buffalo, NY for further stabilization after receiving two months of treatment at a comprehe [...]

1336 10546

Open Access Original Research

Using Mixed Methods to Explore Older Residents' Physical Activity and Experiences of Community Active Aging Friendliness

Received: 29 October 2018;  Published: 06 January 2020;  doi: 10.21926/obm.geriatr.2001098

Abstract

Physical inactivity is the fourth leading risk factor for global mortality and as such, it is critical that physical activity guidelines for health consider equitable access to physical activity opportunities for all, including those aged 65 years and older. The purpose of this study was to examine the intersections of attributes of older people (e.g. income, gender, age, health, physical activity) and attributes of the places they live (e.g. rurality, public transit, sidewalks, parks, community centre) to explain [...]

1357 9249

Open Access Research Article

A Novel Approach to Fall Risk Reduction: Combining Education and Therapeutic Yoga

Received: 03 October 2019;  Published: 03 January 2020;  doi: 10.21926/obm.geriatr.2001097

Abstract

Falls have negative consequences for older adults, but falls can be reduced through interventions that target the reduction of fall risk factors. Cognitive behavioral education programs and therapeutic yoga are two interventions that have independently been used as a means to reduce the risk of falls. The purpose of this study was to determine if adding therapeutic yoga following an education intervention improved well known fall risk factors. Potential participants were recruited through a senior center for a 12-w [...]

1809 10338

Open Access Review

Social Connectedness in Preventing Suicide among Older Adults

Received: 30 August 2019;  Published: 02 January 2020;  doi: 10.21926/obm.geriatr.2001096

Abstract

Social isolation and social disconnectedness have resulted in some older adults ending their lives by suicide; therefore, improving social connectedness has become an integral part of suicide prevention programmes. The purpose of this literature review was to assess the impact of social connectedness interventions for preventing suicide in older adults. It is evident that interventions aimed at promoting social connectedness are intended to alleviate stress and depressive symptoms due to social separation and traum [...]

1969 11954

Open Access Review

Design Guidelines to Reduce Extrinsic Fall Risks in the Built Environment

Received: 28 August 2019;  Published: 16 December 2019;  doi: 10.21926/obm.geriatr.1904095

Abstract

As people age, environments supporting changing needs can potentially impact their quality of life. Aging often leads to a decrease in the ability of people to interpret sensory cues within their environment. Using Pastalan's Empathic Model as a framework, a list of guidelines for the physical environment was established to address the extrinsic risk factors affecting falls. Attention to these items may not prevent all falls but will mitigate some of the external risks that cause falls for older adults. It is the g [...]

1507 12103

Open Access Original Research

Successful Aging and Positive Psychology: Two Empirically Related Perspectives

Received: 19 June 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904094

Abstract

Background: In the last two decades, successful aging (SA) and positive psychology (PP), the two paradigms of health have received great attention. They originate from different approaches, theoretical background, and objectives. Although they share many characteristics, their association remains understudied. This article aims to empirically analyze their possible interrelation. Methods: In this cross-sectional study, 169 healthy, old adults completed several questionnaires to assess the central framework for succ [...]

2096 16202

Open Access Original Research

Women’s Perceptions of the Embodied Experience of Osteoporosis across the Lifecourse

Received: 29 October 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904093

Abstract

Beliefs about the daily experience of a disease are used to identify risk and motivate participation in prevention. For osteoporosis, a disease that is affected by health behaviours throughout the lifecourse, individual perceptions of the disease can affect health decisions and future disease prevalence. Understanding how the experience of osteoporosis is perceived by women at different stages of life can illuminate factors that influence engagement in prevention. Women representing three life stages - young adults [...]

1185 8407

Open Access Original Research

Effects of Enriched Thematic Multi-Sensory Stimulation on BPSD in A Beach Room: A Pilot Study among Nursing-Home Residents with Dementia

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.geriatr.1904092

Abstract

Background: Studies conducted on the effectiveness of psychosocial interventions have indicated that sensory stimulation represents a promising approach to reduce the psychological and behavioral disturbances in people with dementia. Multi-sensory stimulation involves the simultaneous stimulation of multiple senses, through the use of various methods, for example, by using a variety of lights, gentle stimulating music, aromas, and tactile objects, among others. A relatively novel approach is the enriched thematic m [...]

2203 13127

Open Access Review

Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment Options

Received: 06 August 2019;  Published: 04 December 2019;  doi: 10.21926/obm.geriatr.1904091

Abstract

The prevalence of Late-life Depression (LLD) has been estimated between 10% and 15%. Therefore, it is a considerable worldwide problem. The psychopathology is not substantially different from that of depressive episodes in young adults but somatic complaints in combination with end-of-life perspective leave an imprint on emotional experience. The frequent suicidal tendency, especially in old unmated men, remains a particular challenge. It is important to combine psychiatric and somatic diagnostics using modern meth [...]

1490 11721

Open Access Review

The Association between Bone Turnover Markers and Fracture in People with Diabetes: A Systematic Review and Meta-Analysis

Received: 29 August 2019;  Published: 04 December 2019;  doi: 10.21926/obm.geriatr.1904090

Abstract

Background: The increased risk of fractures in individuals with diabetes has been underestimated by conventional fracture predictors such as the bone mineral density T-score or the Fracture Risk Assessment Tool. The present study conducted a systematic review and a meta-analysis to investigate the association between the levels of bone turnover markers (BTMs) and fractures in patients with diabetes. Methods: We conducted a systematic literature search. Eligibility criteria were studies investigating BTMs in patient [...]

1251 9114

Open Access Original Research

Automated Movement Feedback for Recovering Independence in the Sit-to-Stand Movement in an Older Population: A Pilot Randomised Controlled Trial of a Novel System

Received: 23 September 2019;  Published: 02 December 2019;  doi: 10.21926/obm.geriatr.1904089

Abstract

Background: The sit-to-stand (StS) movement is a frequently performed task critical to independent living that is both difficult to perform and associated with falls in older populations. Consequently, the recovery of this movement through supervised practice is a priority during the rehabilitation of older people. Technology may enable self-practice, potentially improving rehabilitation outcomes. The purpose of this study was to evaluate the clinical feasibility and effectiveness of an automated movement feedback [...]

1705 11062

Open Access Case Report

Physical Illness and Emotional Expression in Late Life

Received: 14 August 2019;  Published: 25 November 2019;  doi: 10.21926/obm.geriatr.1904088

Abstract

Louise H., Ph.D was referred to me by her long-term primary care physician (PCP) who was certain that his patient was seriously depressed and in need of medication and possibly psychotherapy. My own assessment, in consultation with a neurologist, was that Louise’s problems with coping were primarily neurological, and that her issues were due to serious (and in one case embarrassing) symptoms. Her neurological problems (mild Parkinsonism and PseudoBulbar Affect, or PBA) are currently being addressed by the neurologi [...]

1144 7890

Open Access Research Article

Balance and Fall Rates are Associated with Chronic Pain, and Improve with Yoga

Received: 29 September 2019;  Published: 25 November 2019;  doi: 10.21926/obm.geriatr.1904087

Abstract

Background: Falls are relatively common in older adults and are associated with chronic pain. Chronic pain may even be a predictor of falls in older adults. However, this relationship has not been studied in adults

1576 9120

Open Access Original Research

Evaluation of the Prevalence of Screening for Dysphagia among Older People Admitted to Medical Services – An International Survey

Received: 15 September 2019;  Published: 15 November 2019;  doi: 10.21926/obm.geriatr.1904086

Abstract

Background: With the increasing age of the world population, the number of old and frail people is increasing. Respiratory disease is a common reason for hospital admission for older people. Aspiration of saliva, which is probably infected, is the likely etiological agent. The incidence of an abnormal swallow is high in frail older people. Despite the high incidence of swallow problems among older people, many hospital services do not routinely screen older people for dysphagia. Methods: A survey, using Research El [...]

2183 29075

Open Access Editorial

Fragility Fractures in the Elderly Osteoporotic Patient and the Efficacy of Fracture Liaison Service Programs

Received: 07 November 2019;  Published: 13 November 2019;  doi: 10.21926/obm.geriatr.1904085

Abstract

None.

1406 8660

Open Access Case Report

Qualitative Evaluation of Interdisciplinary Service Learning Experience to Assess and Manage Fall Risk in Community-Dwelling Older Adults

Received: 15 August 2019;  Published: 29 October 2019;  doi: 10.21926/obm.geriatr.1904084

Abstract

Aim: The purpose of this study was to evaluate faculty and student perceptions of a fall risk assessment and prevention activity for older adults offered in multiple community settings by health professional faculty and students. Background: In the US, the percentage of adults 65 and older who fell was more than 29% in 2018. Among states, Arkansas ranks 48th with 35.2% of older adults reporting a fall (CDC Behavioral Risk Factor Surveillance System, 2018). Methods: Four senior centers in Northwest Arkansas hosted a [...]

1555 10164

Open Access Review

Ageing: The Role of Ageism

Received: 20 June 2019;  Published: 28 October 2019;  doi: 10.21926/obm.geriatr.1904083

Abstract

Worldwide, people are living longer but not necessarily experiencing optimal health since healthy ageing stems from a combination of biological, psychological, and social factors. The growing interdisciplinary literature on ageism from fields such as education, medicine, psychology, and social work increasingly highlights the pivotal role that ageism plays in ageing. Ageism is generally an overlooked factor in understanding and fostering healthy ageing. Ageism creates a negative view of the ageing process as marked [...]

4096 33815

Open Access Research Article

Using Health-Related Quality of Life (SF-36v2®) to Predict Falls in Community-Dwelling Older Adults

Received: 14 September 2019;  Published: 25 October 2019;  doi: 10.21926/obm.geriatr.1904082

Abstract

Background: Falls are the leading cause of hospitalization and death among older adults; therefore, the ability to predict fall risk among older adults is critical. Several performance-based outcome measures exist to assess fall risk. Psychological factors are also associated with fall risk yet can be difficult to assess and are often overlooked. In this study, we investigated whether the Short Form 36 Item Health Survey (SF-36v2®), a measure of health-related quality of life (HRQOL), predicted future falls in [...]

1498 10538

Open Access Concept Paper

Admiral Nursing in Primary Care: Peri and Post-Diagnostic Support for Families Affected by Dementia within the UK Primary Care Network Model

Received: 19 September 2019;  Published: 18 October 2019;  doi: 10.21926/obm.geriatr.1904081

Abstract

The population of the United Kingdom is ageing. In 2017 approximately 18% of the UK population were aged 65 years or over and projected to grow to almost 21% by 2027 according to the Office of National Statistics. Increased age is the greatest risk factor for developing dementia. It is estimated that there are 850,000 people living with dementia in the UK and if current figures relating to incidence and prevalence are realised, this will increase to 1 million people by 2025 and 2 million by 2051. The National Healt [...]

1585 14090

Open Access Original Research

Naming and Framing the Behavioural and Psychological Symptoms of Dementia (BPSD) Paradigm: Professional Stakeholder Perspectives

Received: 08 September 2019;  Published: 11 October 2019;  doi: 10.21926/obm.geriatr.1904080

Abstract

Background: Behavioural and Psychological Symptoms of Dementia and Challenging Behaviour in dementia are just two of a variety of terms for a complex paradigm that covers the most distressing and costly aspects of the condition. The terminology used to describe these aspects can influence what is measured as outcomes and what is considered as evidence of improvement. Unhelpful or outmoded narratives could be a barrier to developing innovative interventions or in determining what works for whom. This UK study explor [...]

1999 18203

Open Access Perspective

Behavioral versus Biological Definitions of Dementia Symptoms: Recognizing that Worthwhile Interventions already Exist

Received: 31 July 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904079

Abstract

Background: The 2018 Alzheimer's Disease Facts and Figures special report includes two new guidelines for measuring dementia symptoms. The first requires that a biomarker (biological factor) be added to a doctor's clinical judgment of the cause of symptoms when determining whether dementia is present. The second involves identifying four stages of dementia: normal cognition, preclinical, MCI and dementia. Now only those with defining brain pathologies and significant symptoms will be judged to be persons with stage [...]

2808 13906

Open Access Research Article

GAPcare: The Geriatric Acute and Post-Acute Fall Prevention Intervention for Emergency Department Patients – A Qualitative Evaluation

Received: 21 August 2019;  Published: 10 October 2019;  doi: 10.21926/obm.geriatr.1904078

Abstract

Background: Three million US emergency department (ED) visits occur for falls each year. The mortality of falls is increasing and only one fourth of older adults report their fall to their primary care provider, suggesting that valuable preventative opportunities are missed. A fall prevention intervention initiated in the ED immediately after a fall has the potential to reduce subsequent falls, but ED providers lack the time and resources to complete fall risk assessments on their patients. GAPcare, the Geriatric A [...]

2807 13709

Open Access Review

Aging in A Changing World – the Impact of Social Contact and Physical Activity on Health-Related Quality among Older People from Austria – A Biological Perspective

Received: 23 June 2019;  Published: 08 October 2019;  doi: 10.21926/obm.geriatr.1904077

Abstract

Background: All over the world we are confronted with an absolute and relative increase in the proportion of older people. In order to develop strategies to keep older people healthy and independent as long as possible, analyses of factors influencing health related quality of life (HRQL) during old age are necessary. The aim of this review is to present the results of three projects carried out in Austria by the author focusing on the impact of social contact and physical activity on HRQL. Methods: The standardize [...]

1514 9888

Open Access Concept Paper

The “PRIMING, TIMING, MIMING” Model of Individualized Behavioural Care Planning for Residents with Dementia

Received: 30 July 2019;  Published: 29 September 2019;  doi: 10.21926/obm.geriatr.1903076

Abstract

The current paper introduces the “Priming/Timing/Miming” Model of Behavioural Care Planning for persons with Dementia. This simple heuristic provides a quick, easy and systematic way to select from the vast number of behavioural strategies offered in the BPSD literature and to organize these in a way that can be incorporated into an individualized Behaviour Care Plan to deliver personal care to persons with dementia and also to develop a larger plan of care. An entire care plan is captured on one double-sided sheet [...]

1555 12962

Open Access Original Research

Sleep Symptoms Differentially Predict Cognition in Younger and Older-Onset Parkinson's Disease

Received: 13 May 2019;  Published: 23 September 2019;  doi: 10.21926/obm.geriatr.1903075

Abstract

Background: Both disrupted sleep and cognitive impairment are frequent in Parkinson’s disease (PD), but the evidence for a relationship between self-reported sleep disturbance and cognitive symptoms has been equivocal. If sleep symptoms differentially predict cognition in different subtypes, effects may be obscured in a general PD sample. Objective: First, to determine whether the associations between participant and disease variables, sleep symptoms and cognitive performance vary by subtype (younger and olde [...]

1808 11058

Open Access Review

Management of Neuropsychiatric Symptoms of Dementia: A Comprehensive Review of the Current Literature

Received: 14 May 2019;  Published: 16 September 2019;  doi: 10.21926/obm.geriatr.1903074

Abstract

Background: Dementia is a progressive and debilitating condition that affects millions of patients in the United States with an enormous impact on healthcare costs, caregivers, and society. Patients with dementia often experience dementia-related neuropsychiatric disturbances, commonly known as Behavioral and Psychological Symptoms of Dementia (BPSD) and more recently Neuropsychiatric symptoms (NPS) in dementia. These symptoms include verbal and physical agitation, aggression, disinhibition, affect lability, apathy [...]

1715 12637

Open Access Review

Facilitation of Social Support through Negative Allosteric Modulation of α5-Associated GABAA Receptors: A Novel Mechanism for the Treatment of Depression, Agitation, and Aggression in the Elderly

Received: 05 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903073

Abstract

Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of α5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also [...]

1551 10331

Open Access Original Research

Wisdom of the Elders: Narratives Enhancing Trainees’ Attitudes Towards Aging

Received: 25 April 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903072

Abstract

Background: Narratives encompass written reflection experiences and hold the potential to display valuable insights into trainees’ thinking. We analyzed narratives from graduate students trained in aging themes, who then interviewed older hospitalized adults (senior partners) about their life experiences. Methods: Three Discovery & Learning Fellows trained on open-ended interviewing, empathy, and aging themes performed semi-structured interviews. Senior partners were hospitalized older veterans. After the [...]

1391 9114

Open Access Original Research

Atrial Fibrillation, Anticoagulation, and Major Bleeding Episodes in Geriatric Patients at the Risk of Falling

Received: 22 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903071

Abstract

Background: Geriatric patients are at risk of atrial fibrillation (AF) and stroke, and the risk of oral anticoagulation (OAC) related bleeding is also presumed to be higher. Detailed knowledge about the prevalence of AF and bleeding pattern in this population is scarce. This study sought to assess the prevalence of AF, use of OAC, and the rate of major bleeding in geriatric patients who are prone to frequent falls. We expect to find a higher prevalence of AF among geriatric patients compared to elderly people of co [...]

1344 9632

Open Access Review

Shedding Light on Manic Syndromes and Dementia

Received: 27 March 2019;  Published: 16 August 2019;  doi: 10.21926/obm.geriatr.1903070

Abstract

Background: Mania in older adults is associated with a high rate of medical and neurological disease. Objective: The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, late-onset, mania, and elderly. Publications found through this indexed search were reviewed for further relevant references. Resultsan [...]

1838 33612

Open Access Original Research

Intranasal Insulin in Alzheimer’s Disease: A Pragmatic Account

Received: 15 March 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903069

Abstract

Pragmatic competence includes the capacity to express illocutionary force and successfully achieve perlocutionary effects, in order to guarantee fully functional communication exchanges. Improved pragmatic competence in patients has been found in patients with Mild Cognitive Impairment (MCI) and early to moderate Alzheimer’s Disease (AD) in the domains of jokes, self-expression and empathy after extended, targeted intranasal insulin therapy. In this paper it is argued that extended intra-nasal insulin treatment can [...]

1699 10108

Open Access Review

The Value Given and Presupposed in Person-Centred Dementia Care

Received: 08 April 2019;  Published: 13 August 2019;  doi: 10.21926/obm.geriatr.1903068

Abstract

Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the standing or status bestowed on one human being by others in the context of relationships and social being and held that respect for the absolute value of each person is a key theme in Western ethical discourse. He was clear thi [...]

1948 17429

Open Access Original Research

Differential Effects of Social Network on Health in Later Life and the Moderating Role of Depression

Received: 23 March 2019;  Published: 12 August 2019;  doi: 10.21926/obm.geriatr.1903067

Abstract

Background: Differential effects of the characteristics of social network on limitations with activities (LWA) and the quality of life (QOL) among older adults, and the moderating role of depression were studied. Methods: The data obtained from two consecutive waves of the Survey of Health, Aging, and Retirement in Europe (SHARE) was examined. Results: Emotional closeness, satisfaction with the social network, and contact frequency were able to predict the QOL and not LWA. Moreover, depression was observed to moder [...]

1313 10381

Open Access Case Report

Personalised Medicine for Dementia: Collaborative Research of Multimodal Non-pharmacological Treatment with the UK National Health Service (NHS)

Received: 08 April 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903066

Abstract

The dominant narrative around dementia argues that progression cannot be halted or reversed. However, evidence on multimodal non-pharmacological treatments formulated around a ‘personalised medicine’ approach challenges this view. This paper reviews the current evidence for dementia prevention utilising such treatments and explains the logic of applying personalised medicine. The functional medicine treatment approach to ‘root cause’ analysis is presented as currently practiced with patients experiencing cognitive [...]

2391 30465

Open Access Review

A Model for Understanding Hispanic/Latino Family Caregiving for Older Adults

Received: 19 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903065

Abstract

Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families for care. Methods: Review published caregiving models for older adults in H/L populations. Results: Gradual and inevitable acculturation of H/L caregivers to U.S. social customs, and the mutual relationship within the [...]

1510 12417

Open Access Review

Insights from Yeast on Oxidative Stress in Alzheimer’s Disease, Focusing on Ahp1p/Prx5

Received: 05 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.geriatr.1903064

Abstract

The yeast, Saccharomyces cerevisiae, the model eukaryote, has provided much understanding of molecular and cellular biology, as well as insights into many human diseases. In this paper we review how yeast studies are contributing to knowledge about the role of oxidative damage to cell health, and how one of the key players in Alzheimer’s disease, amyloid beta (Aβ) is linked to the reactive oxygen species response involving AHP1, which encodes an alkyl hydroperoxidase, Ahp1p, a protein involved in protect [...]

1689 9342

Open Access Review

Curing Alzheimer’s Disease: Myriad Causes and Myriad Cures Await

Received: 12 June 2019;  Published: 16 July 2019;  doi: 10.21926/obm.geriatr.1903063

Abstract

Simplifying the cause of Alzheimer’s disease has lulled the public into believing that the search for a cure is within reach. The disease has captured the attention of researchers worldwide, catapulting the disease as the third most funded research interest (after cancer and HIV). But after a century of pharmacological failures in stopping or slowing the disease, there is a need to examine how the simplified cause evolved and to explore alternate approaches to understanding Alzheimer’s disease. Going beyond the nar [...]

1727 9390

Open Access Review

Role of Artificial Intelligence (AI) Art in Care of Ageing Society: Focus on Dementia

Received: 28 March 2019;  Published: 15 July 2019;  doi: 10.21926/obm.geriatr.1903062

Abstract

Background: Art enhances both physical and mental health wellbeing. The health benefits include reduction in blood pressure, heart rate, pain perception and briefer inpatient stays, as well as improvement of communication skills and self-esteem. In addition to these, people living with dementia benefit from reduction of their non-cognitive, behavioural changes, enhancement of their cognitive capacities and being socially active. Methods: The current study represents a narrative general literature review on availabl [...]

1978 16755

Open Access Original Research

Estimating Potential Cost Containment through Provision of Unplanned Institutional Respite Services to Support Home-Based Care within Japan’s Long-Term Care Insurance System

Received: 19 February 2019;  Published: 09 July 2019;  doi: 10.21926/obm.geriatr.1903061

Abstract

Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on short notice and in emergencies. Methods: This study used city government survey results on service user satisfaction with the Japanese Long-Term Care Insurance (LTCI) system for a mid-sized, Japanese city. From this a range [...]

1545 12941

Open Access Review

Parting with the Concept of Alzheimer’s Disease in Senium

Received: 30 March 2019;  Published: 08 July 2019;  doi: 10.21926/obm.geriatr.1903060

Abstract

The understanding of mental deterioration associated with old age has undergone several changes over the past two centuries, and has spurred major scientific debates. In the 19th century, this disorder was still considered an inevitable part of aging. The beginning of the 20th century offered a histological explanation for presenile dementia, and Alois Alzheimer was credited as the discoverer of a new disease that bears his name to date. In the last quarter of the 20th century, findings of Alois Alzheimer were appl [...]

1485 10004

Open Access Research Article

Comparisons of Target Localization Abilities during Physical and Virtual Rotating Scenes by Cognitively-Intact and Cognitively Impaired Older Adults

Received: 20 August 2018;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902059

Abstract

Background: Previous studies have reported that coordinate information (i.e. distance between any two objects in a specific direction) is encoded differently from Virtual Reality (VR) and physical scenes. However, the accuracy of encoding categorical information (i.e. relative positions of objects) from VR scenes has not been adequately investigated. During this study, we used a novel rotating visual scene to study the effects of aging, prior experience with VR, and dementia on the accuracy of encoding categorical [...]

1492 9344

Open Access Research Article

Wrinkles and Smiles — What is Good Aging? A Technology Assessment Perspective

Received: 31 January 2019;  Published: 27 June 2019;  doi: 10.21926/obm.geriatr.1902058

Abstract

Background: Quality or healthy aging refers to well-being in an older age. In the light of recent changes in the discourse on approaches on positive aging, we aimed to study the way “quality aging” is understood, expressed, and dealt with as a part of contemporary technology assessment (TA), since the nexus between demographic and technological changes has remained a staple topic in TA for at least three decades. Methods: A bottom-up qualitative content analysis was performed to identify the concepts of [...]

1812 11178

Open Access Review

Treating Dementia Early: Limiting Cellular Damage in Brain Tissue

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Abstract

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

1486 9178

Open Access Communication

Making Sense of Senselessness: Contemporary Literary Commentaries on Dementia

Received: 20 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902056

Abstract

Alzheimer’s Disease is increasingly seen as the major health problem in developed countries supplanting cancer and heart disease. The terror with which we respond to dementia, is grounded in a view of dementia as a monstrous descent, ambushing our healthy ageing through an incursion of pathology. The pervasiveness of this view can mean that other perspectives and even the views of those most touched by the challenges of dementia remain unheard. Part of the cultural conversation around dementia is informed by [...]

1391 7927

Open Access Review

Aging, Informed Consent and Autonomy: Ethical Issues and Challenges Surrounding Research and Long-Term Care

Received: 29 January 2019;  Published: 24 May 2019;  doi: 10.21926/obm.geriatr.1902055

Abstract

The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Respect for the autonomy of older persons is highlighted as a cornerstone of care by medical professionals and family members. There remains the challenge, however, of caring for older people who do not have full decision-making cap [...]

2780 34908

Open Access Original Research

Empirical Examination of Caregiving Processes and Outcomes among Adult Siblings of Individuals with Intellectual and Developmental Disabilities

Received: 25 February 2019;  Published: 20 May 2019;  doi: 10.21926/obm.geriatr.1902054

Abstract

Background: Most individuals with disabilities in the US live in family settings; in some families, siblings are default long-term support providers. Although researchers have explored the roles of parent caregivers, the roles of sibling caregivers need attention. Methods: In this study, we examined caregiving processes and outcomes among 322 adult sibling support providers (SSPs) with a range of support roles. Adapting a model of caregiving outcomes, we used structural equation modeling to assess relationships amo [...]

1468 10255

Open Access Review

Admiral Nurse Case Management: A Model of Caregiver Support for Families Affected by Dementia

Received: 26 February 2019;  Published: 10 May 2019;  doi: 10.21926/obm.geriatr.1902053

Abstract

There has been a strong thrust to identify the needs of people with dementia against a background of person-centred care, however, people with dementia do not exist in isolation; they live within relational contexts with family members. Case management is a model of care that has its origins in supporting patients with a long term disease, however, a very practical approach to case management that can support the care needs of both the person with dementia and the family carers is emerging in the UK. Admiral Nursin [...]

2076 16897

Open Access Research Article

The Relationship between Caregiver Stress and Behavioural Changes in Dementia

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Abstract

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston Standardized Cognitive Asse [...]

2125 12588

Open Access Concept Paper

Biological Age versus Chronological Age in the Prevention of Age Associated Diseases

Received: 31 January 2019;  Published: 05 May 2019;  doi: 10.21926/obm.geriatr.1902051

Abstract

Aging is associated with an increased incidence of major diseases, including cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome, quality of life and are commonly applied as age-dependent indications based on evidence of efficacy for specific groups of the aging population. They likely contribute to the observed increase in life expectancy through the reduction of incidence and the retarda [...]

2233 16357

Open Access Project Report

An Evaluation of a Community-Based Psychoeducation Program for Successful Ageing

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

Abstract

Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their outcomes is essential. This study used mixed methods to evaluate cognitive and behavioural changes and to monitor psychological health and active ageing in participants of a longstanding positive ageing psycho [...]

1448 11150

Open Access Original Research

Moderators of Treatment Outcomes from Family Caregiver Skills Training: Secondary Analysis of a Randomized Controlled Trial

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Abstract

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

1859 10821

Open Access Case Report

Daily Observations of Preserved Cognition and Quality of Life after Multiple Therapies for Postmortem-Verified Severe Alzheimer’s

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Abstract

Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows significant preservation of cognition and quality of life in the daily routine of a woman with severe Alzheimer’s who was given multiple therapeutic interventions. Alzheimer’s disease involves multiple d [...]

1313 9091

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

Abstract

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

1505 10792

Open Access Review

Engagement and Utilization of Advance Care Planning and Hospice in Different Older Asian American Populations

Received: 31 October 2018;  Published: 08 April 2019;  doi: 10.21926/obm.geriatr.1902046

Abstract

This research review sought to examine the patterns of engagement in advance care planning (ACP) and utilization of end-of-life (EoL) care treatment services including, but not limited to hospice care, in distinct older Asian American ethnic groups. The review of existing research suggested evidence that empirical studies about different older subpopulations of Asian Americans remains scarce. This research analysed 30 small-scale studies on older Asian Americans’ attitudes and engagement in EoL care planning. The r [...]

1910 13971

Open Access Comment

hTERT Promoter Regulation by Differentiation Mechanisms vs Telomerase Activity in Somatic, Embryonic, and Cancerous Cells

Received: 02 February 2019;  Published: 04 April 2019;  doi: 10.21926/obm.geriatr.1902045

Abstract

Telomere shortening in the somatic cells is one of the most well-documented factors of cellular ageing. Telomeres are composed of tandem hexanucleotide repeats that protect cells from unwanted recombination mechanisms, secure the ends of chromosomes and their stability, and are responsible for limited division capacity. Telomerase is an enzymatic ribonucleoprotein complex, present in embryonic cells, adult stem cells, and germinal progenitors, whose function is to extend the telomeres length by adding the lost tand [...]

1424 10363

Open Access Research Article

Examining the Effectiveness of Two Types of Forgiveness Intervention to Enhance Well-Being in Adults from Young to Older Adulthood

Received: 30 October 2018;  Published: 03 April 2019;  doi: 10.21926/obm.geriatr.1902044

Abstract

Background: Interventions that facilitate positive actions and attitudes seem to play an important role in enhancing psychological health. This study examines the effectiveness of two self-guided interventions with the aim to enhance adults’ well-being through the cultivation of forgiveness skills. Methods: A total of 11 men and 31 women aged 34-80 years were involved (M = 56.57, S.D. = 13.44). All participants were Orthodox Christians, as the average Greeks are, without belonging to a closed religious community. T [...]

1811 19507

Open Access Original Research

The Positive Power of Perception in Late Life: A Study on Subjective Aging and Health among Ethnic Minorities

Received: 17 September 2018;  Published: 29 March 2019;  doi: 10.21926/obm.geriatr.1901043

Abstract

Background: The world’s aging population is growing and diversifying at an unprecedented rate. In preparation for this, the National Institutes of Health and the Centers for Disease Control and Prevention have issued calls to improve the overall health of older adults. A promising avenue of research to improve health in late life has been dedicated to subjective aging; the way people perceive their own aging process. The main objective of this empirical study was to investigate subjective aging in late life among e [...]

1674 65544

Open Access Editorial

Depression and Aging: Role of Social Support

Received: 25 March 2019;  Published: 28 March 2019;  doi: 10.21926/obm.geriatr.1901042

Abstract

Depression and Aging: Role of Social Support

1718 10300

Open Access Review

Association of Telomere Length, a Cellular Aging Marker, with Depression, PTSD and Hostility

Received: 28 December 2018;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901041

Abstract

Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to stressors show notable circulating inflammatory responses with high cortisol reactivity, which increases cell turnover and oxidative stress and may subsequently contribute to shortened TL. This review focuses on the most [...]

2017 12248

Open Access Review

Does Dementia Increase the Risk of Dental Decay?

Received: 09 January 2019;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901040

Abstract

The amount of patients who suffer with dementia is set to rise with an ageing population. As well as living longer, patients will be retaining their natural teeth into their later life and will be less reliant on dentures. From both the current evidence available in the literature, and anecdotally from clinicians experienced in treating patients with dementia, it can be concluded that on balance, patients with dementia appear to be at a greater risk from dental caries (dental decay). However, more research in this [...]

1715 16239

Open Access Perspective

Behavioural and Complementary Interventions for Healthy Neurocognitive Aging

Received: 30 November 2018;  Published: 20 March 2019;  doi: 10.21926/obm.geriatr.1901039

Abstract

Background: While the percent of persons 65 and older is expected to increase to 17% of the world’s population by 2050, this increase in longevity does not necessarily suggest a parallel increase in health status. While aging is an inevitable aspect of living, there are factors which can accelerate morbidity and mortality, as well as factors likely to promote a healthy transition into longevity. This paper addresses behavioural and complementary interventions for healthy neurocognitive aging. Specific evidence-base [...]

3364 20567

Open Access Original Research

Prediction of ADRs and Estimation of Polypharmacy in Older Patient’s Population: Retrospective Study in Russian Gerontology Center

Received: 10 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.geriatr.1901038

Abstract

Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. Prediction of ADRs is a valuable tool to improve pharmacotherapy and outcomes in this category of patients. Objective: Prediction of ADRs in patients ≥ 65 years old, based on GerontoNet risk score with emphasis on polypharmacy. Methods: Pharmacoepidemiological retrospective study of medical records of patients admitted to the Russian Gerontology Clinical Research Center (RGCRC) between 1 [...]

1650 11378

Open Access Original Research

Exploring the Paradox of Care: Differences in Older Adult and Proxy Ratings of Health and Subjective Well-Being

Received: 27 August 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901037

Abstract

Background: The purpose of this study was to examine discrepancies in self-proxy agreement of biopsychosocial factors and the influence of objective well-being and psychosocial resources self and proxy appraisals of subjective well-being in older adults. Methods: Seventy-two older adult-proxy dyads rated the biopsychosocial health of non-cognitively impaired older adults. Results: Proxies underestimated functional ability, psychosocial factors, and overrated negative health outcomes compared to older adults. Older [...]

1523 10341

Open Access Technical Note

Improving the HealthCare of People with Dementia beyond the Diagnosis: The “Carlo Poma Dementia Care Pathway” Study Protocol

Received: 31 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901036

Abstract

The WHO global action plan on the public health response to dementia 2017-2025 stressed the need to have a comprehensive approach with deep interconnections and cross-cutting elements through several action areas. As the elderly population grows worldwide, the number of patients with dementia increases rapidly because age is an important risk factor for developing late-onset dementia. Currently, dementia syndrome represents a true emergency. Once a diagnosis of dementia was made, informal caregivers, patients and t [...]

1456 13297

Open Access Hypothesis

Sporadic Alzheimer Disease and That Developing in Down’s Syndrome: The Immune System Attacking Self Rather Than Suppressing Infectious Disease Invaders, Toll Like Receptors Triggering Excessive Cytosolic Calcium, Excess Calcineurin Activation, Overexpression of Regulator of Calcineurin1, Runaway Beta-Amyloid Production, Synaptic Loss, Destructive Inflammation and Dementia

Received: 29 August 2018;  Published: 26 February 2019;  doi: 10.21926/obm.geriatr.1901035

Abstract

Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self-recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloid production (a component of the innate immune system) causing cytosolic calcium overload. Excessive cytosolic calcium may cause over activation of calcineurin and inactivation of cis-trans prolyl isomerase (Pin1), with [...]

1442 9209

Open Access Review

Cell Senescence, Telomerase, and Senolytic Therapy

Received: 31 December 2018;  Published: 15 February 2019;  doi: 10.21926/obm.geriatr.1901034

Abstract

The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable attention, but both theoretical considerations and published data suggest that the clinical benefits will be transient and that senolytic therapies will likely accelerate long-term degenerative disease. We review the ove [...]

2196 35219

Open Access Research Article

Effect of Six-Months Supplementation with Cholecalciferol on Glycemic and Blood Pressure Control in Elderly Type 2 Diabetic Patients with Vitamin D Deficiency: A Pilot Study

Received: 31 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.geriatr.1901033

Abstract

Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. Our aim was to evaluate in elderly uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-months vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels. Methods: In an open-label pilot study, thirty type 2 diabetic patients (age 71.5 ± 3.2 years, BMI [...]

1755 10408

Open Access Research Article

Key Dimensions of Therapeutic Lies in Dementia Care: A New Taxonomy

Received: 12 December 2018;  Published: 11 February 2019;  doi: 10.21926/obm.geriatr.1901032

Abstract

Background: Research suggests that the use of lies and deception is prevalent within dementia care settings, despite ongoing debates raised about the ethics of this approach. There has been increasing exploration of when and why deceptive practices should be used, but the lack of clarity as to what constitutes a lie has caused difficulty in ensuring that lies are used ethically. The aim of this study was to widen our understanding of the key dimensions that underpin the use of lies, and further to use this informat [...]

1943 15941

Open Access Editorial

Telomere Editorial - Perspectives on Telomeres and Aging

Received: 29 January 2019;  Published: 30 January 2019;  doi: 10.21926/obm.geriatr.1901031

Abstract

Telomere Editorial-Perspectives on Telomeres and Aging

1742 11617

Open Access Research Article

An Examination of How the ‘Household Model' of Care Can Contribute to Positive Ageing for Residents in the ‘Fourth Age’

Received: 15 November 2018;  Published: 24 January 2019;  doi: 10.21926/obm.geriatr.1901030

Abstract

Background: Promoting a good quality of life for the oldest members of society has become a top priority as evidenced in UK policy. The ‘household’ model is a departure from traditional approaches to care provision since it offers person-centred support - combing health and social care - to older people in specially-designed, small, homelike environments. Having gained increasing popularity in care homes across developed countries, the impact of this model of service delivery on residents’ quality of life and its c [...]

2102 14264

Open Access Research Article

Aging and the Art of Happiness: Time Effects of A Positive Psychology Program with Older Adults

Received: 31 October 2018;  Published: 10 January 2019;  doi: 10.21926/obm.geriatr.1901029

Abstract

Background: Research has shown that positive psychology interventions can enhance subjective well-being and reduce depression. However, the efficacy of these programs with older adult populations has been minimally studied. The present study studied the short and long term impact of an intervention enhancing happiness and overall mental well-being in older adults. Methods: The Art of Happiness is an 8-week program conducted at 2 senior centers in the state of Delaware. Each 90-minute class examined a different topi [...]

1950 15635

Open Access Research Article

Acceptance of Information and Communication Technologies for Healthy and Active Aging: Results from Three Field Studies

Received: 31 October 2018;  Published: 04 January 2019;  doi: 10.21926/obm.geriatr.1901028

Abstract

Background: Information and Communication Technologies (ICTs) have the potential to promote healthy aging and increase the quality of life of older adults. However, several barriers like access, performance, psychological, and privacy issues still exist against fully deploying ICT solutions for older adults. To determine useful methods to overcome such barriers, this work investigated the possible factors that prevent elders from directly accepting ICT services based on three field studies. Methods: The Unified The [...]

1630 9807

Open Access Review

What Activities Count as Active Aging? The Challenge of Classifying Diversity

Received: 07 November 2018;  Published: 26 December 2018;  doi: 10.21926/obm.geriatr.1804027

Abstract

Active aging is a concept used to describe and promote lifestyles that contribute to a healthy aging process. However, these lifestyles vary widely, and the concept of active aging encompasses many activities. This paper considers two axes to classify the range of activities that can contribute to active aging: the resources needed to carry out such activities (low and high-resource needs) and the main orientation of the activities (self-oriented vs. activity with others). To illustrate this classification, three t [...]

1826 11680

Open Access Concept Paper

Understanding the Functional Roles of Multi-Modal Processing and Gc Activation In Older People's Performance in Caregiving Training

Received: 05 October 2018;  Published: 25 December 2018;  doi: 10.21926/obm.geriatr.1804026

Abstract

The current article addresses the working memory constraints experienced by older people in caregiving training. Two different approaches aiming to free the older people’s working memory space were discussed. They include multi-modal visual processing and Gc activation. The emphasis was on the theoretical underpinnings of both approaches with empirical evidence from the research and literature to demonstrate their effectiveness in older people’s caregiving training. Further discussion was made with respect to the t [...]

1638 10877

Open Access Research Article

Wisdom and Curiosity Among Older Learners: Elucidating Themes of Well-Being from Beautiful Questions in Older Adulthood

Received: 30 October 2018;  Published: 24 December 2018;  doi: 10.21926/obm.geriatr.1804025

Abstract

Background: Wisdom and curiosity require greater attention in the lifelong learning literature pertaining to older adulthood. Lifelong learning can assist older adults in amalgamating wisdom and pursuing their curiosities, but how wisdom is amalgamated and how curiosity is pursued in older adulthood needs more exploration. Methods: This qualitative study investigates subthemes of wisdom amalgamation and curiosity pursuits elucidated from interviews of older adults who participated in a university-based lifelong lea [...]

2078 18906

Open Access Original Research

Simplifying Caregiver Resources in Eldercare: Identifying the Support Needs of Caregiving Employees

Received: 26 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.geriatr.1804024

Abstract

Background: The majority of long-term care provided to older adults and persons with disabilities is provided by unpaid family caregivers and friends. Employers have a stake in long-term care services as well since 60% of caregivers are employed outside the home, 49% have gone in late, left early, or taken time off during the day to deal with caregiving issues, and 15% have taken a prolonged leave of absence. Additionally, 87% of employed caregivers make telephone calls for caregiving from work. Presenteeism, the s [...]

1608 11181

Open Access Original Research

25-hydroxyvitamin D Levels are Associated with Cognitive Dysfunction in Type 2 Diabetes and the Metabolic Syndrome: A Preliminary Examination

Received: 01 August 2018;  Published: 05 December 2018;  doi: 10.21926/obm.geriatr.1804023

Abstract

Background: Type 2 diabetes (T2DM) and metabolic syndrome are linked to pathological changes in the brain and increased likelihood of cognitive impairment. 25-hydroxyvitamin D insufficiency is commonly found in this population and is associated with cognitive dysfunction in other patient groups. This preliminary study sought to examine whether 25-hydroxyvitamin D levels are is associated with cognitive deficits in this population. Methods: Twenty individuals with T2DM and metabolic syndrome (n = 20, aged 45 to 72) [...]

1529 11383

Open Access Review

A Call to Arms for the Aged Care Sector: A Spotlight on Systematic Abuse and Neglect of Older Disabled Persons

Received: 17 July 2018;  Published: 28 November 2018;  doi: 10.21926/obm.geriatr.1804022

Abstract

With rapidly aging populations worldwide there will be an increasing need to focus attention on the expected increase in disability with advancing age. Drawing upon established literature this paper aims to highlight the contribution of anthropology including selected research findings and contemporary understandings surrounding ageism, abuse and exploitation of older disabled persons. Health care providers within the context of the aged care sector are challenged to unburden themselves with negative images and pra [...]

1879 13467

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