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Open Access Original Research

Preliminary Comparative Sodium Analysis of Different Tempeh Types in Indonesia and Its Benefits for Hemodialysis

Received: 01 April 2025;  Published: 19 September 2025;  doi: 10.21926/rpn.2503020

Abstract

Hemodialysis patients require a diet rich in protein that is easily digestible, such as tempeh. Tempeh is a local Indonesian food product that can be purchased at a low price. Tempeh has a low sodium content, but there has never been an analysis related to the difference in sodium content in local Indonesian soybean tempeh products and imported soybean tempeh. This study was to compare the sodium analysis of different tempeh types in Indonesia as a preliminary study for the subsequent research to fulfill a high-pro [...]

762 3826

Open Access Review

Importance of SLAPE Solar Panels, Electrochemical CO2 Reduction, Alkaline Electrolyzers and Alkaline Fuel Cells Development to Achieve United Nations Sustainable Development Goals

Received: 31 July 2025;  Published: 17 September 2025;  doi: 10.21926/rpse.2503013

Abstract

The United Nations Organization (UNO) in the year 2015 formulated seventeen sustainable development goals (UNO’s 17 SDGs) to be achieved by the end of the year 2030. The so far achieved progress indicates that none of these UNO’s 17 SDGs can be achieved before the deadline. In fact, all these goals can be achieved by developing suitable technologies to fully capture and utilize all the renewable energy resources available on earth to meet all the energy needs of society without any backup from fossil fu [...]

1190 6817

Open Access Original Research

Bioremediation of Organic Compounds and Trace Metals from Landfill Leachate Using Lactobacillus kefiri Strains: A Sustainable Approach Based on Facultative Treatment

Received: 09 November 2023;  Published: 16 September 2025;  doi: 10.21926/rpm.2503014

Abstract

The sustainable management of water resources is increasingly recognized as a critical component of environmental conservation and socio-economic development. Among the most challenging aspects of wastewater treatment is the effective remediation of landfill leachate, a complex and highly polluted effluent characterized by high levels of organic matter, ammonia, turbidity, and heavy metals. This study investigates an integrated treatment approach that combines chemical coagulation using aluminum sulfate with a subs [...]

854 4152

Open Access Original Research

Annual Costs and Nursing Care Interventions to Prevent Falls Over 1 Year in a Long Term Care Facility

Received: 11 March 2025;  Published: 16 September 2025;  doi: 10.21926/obm.geriatr.2503327

Abstract

Evidence shows the use of interventions to prevent falls are costly to healthcare facilities. Using a sample of older adult patients who fell at least once during the intervention year of a three-year cohort study in one long term care nursing facility, at a continuing care community providing skilled nursing and assisted living, we provide detailed evidence of the number and costs of durable medical equipment and number and type of non- durable medical nursing care interventions utilized to prevent subsequent fall [...]

1011 4836

Open Access Case Report

Mindfulness Training to Reduce Anxiety in Socially Isolated Individuals with Schizophrenia: A Case Study

Received: 17 May 2025;  Published: 15 September 2025;  doi: 10.21926/obm.neurobiol.2503301

Abstract

This article aims to evaluate the impact of mindfulness training on Mr. A, a 17-year-old adolescent with schizophrenia experiencing social isolation and severe anxiety. The subject, Mr. A, is a 17-year-old male who presented with significant anxiety symptoms, including excessive worry, restlessness, difficulty concentrating, irritability, heart palpitations, rapid breathing, and sleep disturbances. These symptoms were accompanied by behaviors of social withdrawal, emotional detachment, and reluctance to communicate [...]

903 4022

Open Access Case Report

Netherton Syndrome in a 9-Month-Old Child: Unraveling a Complex Dermatologic Disorder

Received: 05 June 2025;  Published: 15 September 2025;  doi: 10.21926/obm.genet.2503311

Abstract

Netherton syndrome is a rare autosomal recessive disorder caused by mutations in the SPINK5 gene, leading to LEKTI protein dysfunction, impaired skin barrier function, and immune dysregulation. It manifests as a triad of ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), and atopic diathesis, often mimicking other inflammatory dermatoses. We report a 9-month-old Javanese Indonesian male infant presenting with extensive erythematous, scaly skin lesions and severe pruritus. Laboratory tests revealed [...]

817 3535

Open Access Original Research

Health Outcomes Associated with Community Senior Center Fitness Classes: Influence of Activity Type and Baseline Physical Activity Level

Received: 09 June 2025;  Published: 12 September 2025;  doi: 10.21926/obm.geriatr.2503326

Abstract

Senior centers serve as community anchors for the approximately 57.8 million older adults in the U.S., offering a range of health promotion programs, including exercise classes. This study examined how the type of exercise programs at senior centers influences older adults’ health (mental, physical, and quality of life) and how baseline physical activity levels may influence these changes as part of a statewide health promotion program evaluation in senior centers in Delaware. The exercise programs offered were bas [...]

1232 5266

Open Access Original Research

Association of Dopamine D2 Receptor (DRD2) C939T and a Lack of Association of Tumor Necrosis Factor-β (TNF-β) +A252G Polymorphisms with Susceptibility to Migraine in A Northern Iranian Population

Received: 09 June 2025;  Published: 11 September 2025;  doi: 10.21926/obm.genet.2503310

Abstract

Genetic factors including TNF-β and DRD2 have been considered as essential components in the etiology of migraine. Several studies have investigated the association between TNF-β +A252G or DRD2 C939T polymorphisms and migraine risk, with debatable results. We aimed to examine whether TNF-β +A252G and DRD2 C939T polymorphisms confer genetic susceptibility to migraine in a Northern Iranian case-control sample. In total, 151 migraineurs (105 with MO 46 with MA) and 144 healthy control subjects were included in this st [...]

1405 4437

Open Access Original Research

Photon Recycling for Indoor Energy Harvesting: Optical Optimization of LED-Driven Silicon Photovoltaic Systems

Received: 06 July 2025;  Published: 11 September 2025;  doi: 10.21926/jept.2503013

Abstract

Indoor environments offer a unique opportunity for photon recycling using LED-based illumination, particularly to address energy limitations of solar photovoltaic (PV) systems during nighttime or in low-light conditions. This study presents an optical and electrical performance evaluation of silicon-based photovoltaic (SPV) panels operating under controlled indoor LED lighting. Despite the low irradiance (~1.4 mW/cm2), significant power output was achieved through engineered panel configurations and optimized light [...]

1241 5688

Open Access Concept Paper

Toward a Unifying Transcultural Perspective on Illness, Health and Wellbeing: A Theoretical Proposition

Received: 04 March 2025;  Published: 11 September 2025;  doi: 10.21926/obm.icm.2503038

Abstract

This paper presents a unifying transcultural perspective on human illness, health and wellbeing by integrating insights from cognitive psychology, existential psychotherapy, Zen philosophy, Traditional Chinese Medicine (TCM), and quantum consciousness theory. Kahneman and Tversky’s work on heuristics and biases highlights cognitive constraints shaping decision-making, while Yalom’s existential therapy explores fundamental struggles with death, freedom, and meaning. Watts’ Zen philosophy critiques the illusion of eg [...]

964 3959

Open Access Review

The Cellular Mechanism of Aging as Programmed Epigenetic Phenomenon: From Hypothesis to Scientific Evidence

Received: 04 December 2024;  Published: 10 September 2025;  doi: 10.21926/obm.geriatr.2503325

Abstract

There is a main difference between theories explaining aging as an adaptive phenomenon that is determined and modulated by genes (i.e., the result of a specific “program”) and theories explaining aging as a non-adaptive phenomenon caused by the accumulation of random degenerative events. In fact, for adaptive theories, a genetically determined and modulated program determining aging is indispensable, while for non-adaptive theories, such a program cannot exist. However, there appears to be strong evidence to suppor [...]

1480 5969

Open Access Perspective

Atimiaphobia: A Phenomenological Account of the Fear of Losing Honor or Being Labeled Shameless due to the Sexual Values Assigned to Femininity

Received: 30 May 2025;  Published: 10 September 2025;  doi: 10.21926/obm.icm.2503037

Abstract

Honor and shame function as moral currencies in many collectivistic cultures, shaping individual behavior, gender roles, and psychosocial well-being. This paper introduces Atimiaphobia—a newly proposed specific phobia defined as the intense and persistent fear of losing honor (particularly for men) or being labeled as shameless (particularly for women). Rooted in patriarchal, collectivist, and honor-based cultures, atimiaphobia manifests through intrusive thoughts, hypervigilance, emotional turmoil, and compu [...]

1049 5260

Open Access Review

Antibody-Mediated Rejection in Kidney Transplantation: Immunopathogenesis, Innate–Adaptive Crosstalk, and Therapeutic Advances

Received: 17 April 2025;  Published: 10 September 2025;  doi: 10.21926/obm.transplant.2503258

Abstract

Antibody-mediated rejection (ABMR) remains a major barrier to long-term graft survival in kidney transplantation. Defined by the presence of donor-specific antibodies (DSAs) and characteristic histological changes, such as C4d deposition in peritubular capillaries, ABMR can present acutely, chronically, or subclinically, often manifesting as graft dysfunction. Recent advances in genomic profiling and diagnostic assays have improved our understanding of its pathophysiology, yet therapeutic strategies remain limited. [...]

1989 19118

Open Access Review

The Role of Telomeres in Senescence, Aging and Disease: Fiction and Reality

Received: 21 May 2025;  Published: 09 September 2025;  doi: 10.21926/obm.geriatr.2503324

Abstract

Telomeres are repetitive structures at the ends of linear chromosomes. Due to incomplete DNA replication at the end of linear DNA molecules, the so called “end replication problem”, telomeres shorten consecutively during cell division. In addition, telomere sequences are highly susceptible to oxidative stress damaging telomeres and resulting in their dysfunction even in non-dividing cells. Telomere shortening has been identified as one of the underlying causes for replicative senescence that can also contribute to [...]

1265 14471

Open Access Review

Precision Medicine in Liver and Lung Transplantation: Integrating Immunology, Regenerative Therapies, and Computational Advances

Received: 25 May 2025;  Published: 09 September 2025;  doi: 10.21926/obm.transplant.2503257

Abstract

Liver and lung transplantation remain among the most intricate and resource-intensive arenas in modern medicine, challenged by organ scarcity, immunological complexities, and the persistent threat of rejection. According to recent WHO and UNOS reports, approximately 100,000 patients globally await liver transplants annually, with only 30-40% receiving transplants, resulting in waitlist mortality rates of 15-20%. Similarly, lung transplant demand exceeds supply by a factor of 4:1, with 5-year survival rates remainin [...]

1161 5055

Open Access Review

Medical Digital Technologies in Older Patients with Cardiac Disease Achievements and Drawbacks

Received: 17 February 2025;  Published: 09 September 2025;  doi: 10.21926/obm.geriatr.2503323

Abstract

Older adults are a growing population characterized by a high prevalence of multimorbidity and age-related conditions, such as organ and pharmacokinetic dysfunction. Medical digital technologies have emerged through the combined use of wearable, implantable, and insertable medical devices with digital systems. Gerontology aims to help older patients with disabilities utilize these technologies. These technologies are used in high-tech medical centers, particularly among older cardiac patients. Many cardiac societie [...]

880 3559

Open Access Original Research

Effect of Oil Palm Broom Fiber on the Mechanical Properties of Rice Husk Ash–Blended Concrete

Received: 04 June 2025;  Published: 04 September 2025;  doi: 10.21926/rpm.2503013

Abstract

The high carbon footprint of cement production and the cost and environmental impact of steel reinforcement make conventional concrete unsustainable for long-term use. Reducing cement consumption and identifying sustainable, cost-effective alternatives to steel are critical for lowering construction’s ecological and economic burden. Bio-based supplementary cementitious materials (SCMs), such as rice husk ash (RHA), and natural plant fibers show promise, but prior studies have mostly tested them separately or with v [...]

3018 12577

Open Access Review

The Essentials of Cell-Mediated Immunity Assays for the Management of CMV Infection after Solid Organ Transplantation

Received: 12 March 2025;  Published: 04 September 2025;  doi: 10.21926/obm.transplant.2503256

Abstract

Provided that cell-mediated immunity (CMI) is known to be vital in managing CMV infection post-transplant along with improving methods to predict the development of cytomegalovirus (CMV) following transplant, CMV-specific-cell-mediated immunoassays have been developed, commercially and research based, to be used in conjunction with pre-transplant CMV serological testing and prophylaxis to help tailor an individual care plan post-transplant. In this review, we assess the status of CMV CMI assays, and their potential [...]

850 4258

Open Access Case Report

The Homozygous c.612C>G Mutation in C1QBP is Associated with Late-Onset Progressive External Ophthalmoplegia

Received: 30 November 2024;  Published: 04 September 2025;  doi: 10.21926/obm.genet.2503309

Abstract

Biallelic pathogenic variants in C1QBP are an infrequent, yet increasingly recognised, cause of progressive external ophthalmoplegia (PEO). Although most published cases include cardiomyopathy, isolated late‑onset PEO without cardiac disease remains exceptional. To characterise, for the first time, a Moldavian‑Ukrainian pedigree in which homozygous c.612C>G (p.Phe204Leu) in C1QBP causes autosomal‑recessive PEO in the absence of cardiomyopathy, thereby expanding the phenotypic spectrum of C1QBP‑related disease. W [...]

753 3759

Open Access Perspective

Therapeutic Carbohydrate Reduction for Lipedema: Guidelines for a Patient-Centered, Holistic Approach

Received: 31 May 2025;  Published: 03 September 2025;  doi: 10.21926/rpn.2503019

Abstract

Lipedema is a chronic, often misdiagnosed disease characterized by painful, disproportionate fat accumulation in the extremities. Commonly mistaken for obesity or lymphedema, lipedema primarily affects women and has long been thought to be resistant to dietary intervention, a belief originating from its initial description by Allen and Hines at the Mayo Clinic in 1940. However, emerging research challenges this notion, revealing that individuals with lipedema often respond positively to therapeutic carbohydrate (CH [...]

4182 34479

Open Access Original Research

Psychometric Properties of the Persian Version of the Interpersonal Mindfulness Scale (IMS) among Iranian Adolescents

Received: 11 February 2025;  Published: 01 September 2025;  doi: 10.21926/obm.neurobiol.2503300

Abstract

Interpersonal mindfulness, involving present-moment awareness and acceptance during social interactions, is crucial for emotional regulation and adaptive interpersonal functioning. This study examined the psychometric properties of the Persian version of the Interpersonal Mindfulness Scale (IMS), a 27-item instrument with four subscales: presence, awareness of self and others, nonjudgmental acceptance, and nonreactivity. The cross-sectional sample included 15- to 17-year-old Iranian adolescents (2023–2024), r [...]

1120 6046

Open Access Original Research

Neural Network of Alpha Rhythm rs-EEG Activity for the Assessment of Consciousness in Psychopathology

Received: 18 December 2024;  Published: 29 August 2025;  doi: 10.21926/obm.neurobiol.2503299

Abstract

Consciousness is an integrative process that combines several executive functions, as well as the analytical and synthetic activity of the brain. In some psychopathological conditions, in particular, in schizophrenia, low-information "borderline" disorders of the executive functions and consciousness are often formed at the onset. The present study was aimed at assessing the integration of the bran alpha regulatory system and the modulation of consciousness based on the data of recording the alpha rhythm of resting [...]

957 4704

Open Access Review

Engaging with an Industrial Pandemic: Drivers of and Responses to the Expansion of Ultra-Processed Foods in East and Southern Africa

Received: 14 January 2025;  Published: 29 August 2025;  doi: 10.21926/rpn.2503018

Abstract

Intensified marketing and expanding consumption of ultra-processed foods (UPFs) that contain high sugar, salt, trans-fats and other additives and sugar sweetened beverages in Sub-Saharan Africa (SSA) are associated with rising obesogenic environments and non-communicable diseases, termed by some an ‘industrial pandemic’ due to its commercial drivers and cross border nature. This review paper addresses the question of how far SSA, positioned at an early point of a rising wave, is controlling this growing health chal [...]

1527 5926

Open Access Interview

An Interview with Prof. Rosita Gabbianelli

Received: 24 August 2025;  Published: 27 August 2025;  doi: 10.21926/rpn.2503017

Abstract

An Interview with Prof. Rosita Gabbianelli

607 2635

Open Access Original Research

Duration of Hospitalization is Associated with the Gut Microbiome in Patients Undergoing Hematopoietic Stem Cell Transplantation: Early Results from a Randomized Trial of Home Versus Hospital Transplantation

Received: 24 April 2025;  Published: 25 August 2025;  doi: 10.21926/obm.transplant.2503255

Abstract

Home-based hematopoietic stem cell transplantation (HCT) is an innovative care model with growing interest, but its impact on the gut microbiome remains unexplored in a randomized setting. We present interim results from the first randomized controlled trials (RCT) evaluating the effect of HCT location—home versus hospital—on gut microbial diversity and antimicrobial resistance (AMR) gene carriage. We hypothesize that patients randomized to undergo home HCT would have higher gut taxonomic diversity and lower AMR ge [...]

2143 5563

Open Access Original Research

Fairness and Reasonableness Tariff Indicator (FRTI) to Meter and Compare Rate Policy in the Electricity Regimes. The Case of Argentina in 2022

Received: 01 May 2025;  Published: 25 August 2025;  doi: 10.21926/jept.2503012

Abstract

The tariff policy for energy services is a fundamental issue for today's societies, especially for end users, including residential, commercial, and industrial. The main objective of this paper is to propose a statistical method to calculate, compare, and evaluate policies of this nature. To this end, firstly, it is intended to rethink an old concept on this type of policy, the principle of fairness and reasonableness, through the linkage with the perspective of human rights, specifically with the right to energy, [...]

1113 5731

Open Access Review

Physiological Impact of Milk on Multiple Health Outcomes in Human

Received: 19 December 2024;  Published: 20 August 2025;  doi: 10.21926/rpn.2503016

Abstract

Milk is best known as a nutrient-rich fluid produced by the mammary glands of mammals, designed primarily to feed young. In the human diet, cow milk is most prevalent, but milk of other mammals and plant milk are common too. This study aims to investigate milk's nutritional value in various age groups and review opposing evidence of its effect on cardiovascular diseases in adults. It is a literature-based strategy to synthesize information from observational and meta-analytic studies. The milk content—macronutrient [...]

2334 13355

Open Access Review

A Review on the Ethnomedicinal Plants Used in Zimbabwe for the Treatment and Management of Skin Conditions: Perspectives on Pharmacological and Toxicological Evaluation

Received: 05 March 2025;  Published: 19 August 2025;  doi: 10.21926/obm.icm.2503036

Abstract

Medicinal plants remain central to healthcare in Africa, where up to 80% of the population relies on traditional remedies to manage a range of health conditions, including skin ailments. In Zimbabwe, the country's rich biodiversity and favourable agroecological zones support a diverse range of ethnomedicinal plants. However, much of the knowledge surrounding these plants remains dispersed and scientifically under-evaluated. This review consolidates evidence from ethnobotanical surveys, peer-reviewed research, and g [...]

2156 14601

Open Access Review

Plant-Derived Nanoparticles in Cancer Therapy: A Comprehensive Review of Recent Advances and Future Prospects

Received: 04 July 2025;  Published: 18 August 2025;  doi: 10.21926/obm.genet.2503308

Abstract

Cancer continues to be one of the leading causes of global death, and conventional therapies have limited efficacy because of their toxicity, drug resistance, and off-target effects. Plant-derived nanoparticles (PDNPs) have emerged as suitable alternatives as they have biocompatibility, biodegradability, and multifunctional therapy. In this review, we discussed the recent advancements in PDNPs for cancer therapy, including the green synthesis of PDNPs using phytochemical (flavonoids, terpenoids) reducing and cappin [...]

1605 8474

Open Access Review

Trends in Breast Cancer Epigenetics Research from 1993 to 2023: A Bibliometric Analysis

Received: 12 January 2025;  Published: 15 August 2025;  doi: 10.21926/obm.genet.2503307

Abstract

Breast cancer is a significant health problem. Epigenetic alterations that influence gene expression were implicated in breast cancer pathogenesis. Bibliometric analysis can be done to evaluate the existing literature and identify gaps and emerging trends. This bibliometric analysis aims to provide an overview of the current landscape of global breast cancer epigenetics research, identify existing networks of countries and authors’ keywords, and assess the association of a country’s socioeconomic indica [...]

871 5173

Open Access Review

A Systematic Literature Review on the Application of Explainable AI Approaches in the Assessment of Autism Spectrum Disorder

Received: 16 January 2025;  Published: 15 August 2025;  doi: 10.21926/obm.neurobiol.2503298

Abstract

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with significant heterogeneity in symptoms and comorbid conditions. Studies have shown the value of early and accurate diagnosis in mitigating the associated social and behavioral challenges. Recently, studies have demonstrated the potential of machine learning (ML) models in identifying ASD patterns from neuroimaging, genetic, and behavioral data. However, the limited interpretability of these models poses a barrier to their clinical adopti [...]

1120 8154

Open Access Short Review

Loneliness or Solitude: How Are They Different?

Received: 08 May 2025;  Published: 14 August 2025;  doi: 10.21926/obm.neurobiol.2503297

Abstract

Loneliness, social isolation, aloneness, and solitude may be used interchangeably by some who may miss the difference between them. Loneliness is the experience of being alone, or perceiving that one is alone and unimportant to others. Solitude is being geographically isolated out of one’s choice. Loneliness is not a feeling, but a multidimensional construct which is expressed cognitively, behaviorally and affectively. solitude is also reviewed and a clear distinction between loneliness and solitude is established. [...]

1970 13326

Open Access Original Research

Lithium Stable Flexible Polyethylene Oxide-Based Composite Electrolyte with High Lithium-Ion Conducting NASICON-Type Solid Electrolyte for Lithium Batteries

Received: 28 April 2025;  Published: 13 August 2025;  doi: 10.21926/jept.2503011

Abstract

Solid lithium-ion conducting polymer electrolytes are attractive candidates for battery applications because they are flexible and less flammable, and can be easily prepared as large-sized thin films. However, the room temperature conductivity of conventional polymer electrolytes is relatively low, and detrimental lithium dendrite formation is observed at high current density. In this study, a composite polymer electrolyte of polyethylene oxide (PEO) with lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) and a hi [...]

1073 6066

Open Access Case Report

Feasibility and Physiological Effects of a Home-Based Swallow Exercise Program Using sEMG Biofeedback in Prefrail Older Adults: A Case Series

Received: 28 April 2025;  Published: 13 August 2025;  doi: 10.21926/obm.geriatr.2503322

Abstract

Age-related decline in swallowing function increases the risk of dysphagia in older adults. Strengthening the muscles involved in swallowing through proactive training may help prevent such decline, particularly in prefrail individuals. This case series evaluated the feasibility and physiological effects of a home-based effortful swallow training program in three prefrail older adults without swallowing impairments. The intervention used a wearable surface electromyography biofeedback device (Mobili-T®) to provide [...]

1115 6277

Open Access Review

Applications of Generative Large Language Models in Environmental Science: A Systematic Review

Received: 07 April 2025;  Published: 12 August 2025;  doi: 10.21926/aeer.2503028

Abstract

Environmental science addresses critical global challenges, including climate change, biodiversity loss, and sustainability. These complex topics generate a vast amount of both structured and unstructured data, from remote sensing output to policy documents, guidelines, and scientific literature. Effectively processing and utilizing this information is essential for advancing research and supporting decision-making. Large Language Models (LLMs) have shown remarkable capabilities in natural language understanding an [...]

2669 12880

Open Access Original Research

Transforming Community Strategy from Population Health to Quality Aging — The Role of Digital Technologies

Received: 03 March 2025;  Published: 11 August 2025;  doi: 10.21926/obm.geriatr.2503321

Abstract

Aging is a multifaceted journey shaped by diverse life-course experiences, which contribute both to the challenges populations face in achieving their health goals and to the competencies they can bring to sustain health and aging. Community strategies designed to support population health—by leveraging technology and external partners—require transformation to effectively extend their focus to aging-related goals. In this paper, we adopt a service lens to examine how these community strategies, which co-produce pr [...]

1034 6157

Open Access Short Review

Maximal 4-Second Cycle Accelerations Attenuate Sarcopenia and Improve Cardiovascular Function in Older Adults

Received: 20 February 2025;  Published: 08 August 2025;  doi: 10.21926/obm.geriatr.2503320

Abstract

The shrinkage of muscles with age, beginning at 30 y and accelerating in old age, is due largely to atrophy of fast-twitch muscle fibers (FT) partly from disuse. It was our purpose to develop an exercise program that is effective and time efficient at stimulating FT, as well as slow-twitch fibers (ST), to offset their atrophy. FT are recruited during movements requiring very high force and/or high velocity. We developed a safe exercise cycle that allows a person to ‘accelerate’ with the maximal effort needed to rec [...]

1068 5192

Open Access Original Research

Treatment Choices and Healthcare Services Utilization Amongst Lumbosacral Radiculopathy Patients: Results from a Randomized Controlled Trial

Received: 06 January 2025;  Published: 07 August 2025;  doi: 10.21926/obm.icm.2503035

Abstract

Lumbosacral radicular pain (LRP) is a common sequelae of low back pain, the world’s leading cause of years lived with disability. LRP typically causes numbness, weakness, and tingling into the lower extremity and is associated with high rates of pain and impaired function. Despite its prevalence, there is significant heterogeneity among clinical practice guidelines for the treatment of LRP, which may contribute to poor patient outcomes. The aim of the present study was to identify treatments that participants [...]

2303 5953

Open Access Original Research

Morpho-Biochemical Characterization and Genetic Analyses of the Traits of Mungbean Genotypes Confined with Yield Attributing Traits and Salinity Stress Tolerance

Received: 31 May 2025;  Published: 07 August 2025;  doi: 10.21926/obm.genet.2503306

Abstract

Low phenotypic and genotypic variability for yield-attributing traits and susceptibility to salinity stress are constraints of mungbean productivity. The objectives of the study are to phenotype a set of exotic mungbean genotypes for yield-attributing traits and salinity tolerance, as well as to conduct genetic analysis of these traits for efficient selection. Three consecutive experiments were conducted to fulfill these objectives. In the first experiment, 26 mungbean genotypes were evaluated for yield traits unde [...]

1348 6597

Open Access Review

Exercise Training and Cardioprotection in Cardiovascular Disease: A Review of Mechanisms

Received: 27 November 2024;  Published: 05 August 2025;  doi: 10.21926/obm.icm.2503034

Abstract

Cardiovascular disease remains the leading cause of death worldwide, prompting extensive research into effective methods for treatment and prevention. Among these, exercise training and physical activity are widely recognized as the safest and most effective strategies for improving health. Specifically, exercise training has been explored for its role in cardioprotection, particularly in reducing damage caused by ischemia-reperfusion (I/R) injury and myocardial infarction (MI). Both high-intensity interval trainin [...]

921 4833

Open Access Review

Advancing Objective Pain Measurement: Exploring the Potential of Electroencephalography Biomarkers

Received: 26 February 2025;  Published: 05 August 2025;  doi: 10.21926/obm.neurobiol.2503296

Abstract

Chronic pain involves complex cortical and subcortical changes, suggesting that brain electrical activity may be a potential biomarker for nociceptive processing. Pain leaves its signature in the brain's oscillatory patterns, yet limited studies have explored the neurophysiological alterations associated with chronic pain. This review examines the pain detection method currently used in clinical settings, the potential of neurophysiological features to become brain oscillatory brain biomarkers, and their use in fut [...]

1626 9419

Open Access Review

Maladjustment in Minority Youth from Community Network Disparities in the COVID-19 Lockdown Environment

Received: 17 April 2024;  Published: 04 August 2025;  doi: 10.21926/obm.neurobiol.2503295

Abstract

Pandemic lockdown orders resulted in closures to critical community networks. One such infrastructure was community recreation centers/parks. This infrastructure serves a critical role in building psychosocial wellness for youth. Socioeconomic minority youth face baseline disparity in center/park distribution and services. Youth recreation activity declined 50% as result of lockdown orders with corresponding decline in youth mental health status. Despite overall youth activity decline, White and high socioeconomic [...]

672 3303

Open Access Editorial

Advances in Photocatalytic Methods for Organic Pollutant Removal

Received: 01 July 2025;  Published: 03 August 2025;  doi: 10.21926/cr.2503007

1687 5266

Open Access Review

Quantum Diamonds and the Future of Advanced Processors, Review on Benefits and Challenges

Received: 09 April 2025;  Published: 03 August 2025;  doi: 10.21926/rpm.2503012

Abstract

Nowadays, the development of advanced processors plays a key role in the progress of humanity and the discovery of new sciences, and quantum computers play an essential role in this regard. In this regard, the development of new generation processors is necessary for the development of quantum computers. Quantum diamonds, with their astonishing properties, especially the presence of nitrogen-vacancy (NV) centers in their crystalline structure, are among the most advanced emerging technologies in the field of quantu [...]

3907 13056

Open Access Original Research

“At My Age, Its Perhaps the End of My Walking or the End of a Lot of My Life”: A Phenomenological Study of the Lived Experiences of a Serious Fall to Independent Older Adults

Received: 04 February 2025;  Published: 01 August 2025;  doi: 10.21926/obm.geriatr.2503319

Abstract

The purpose of this original research was to describe the lived experience and meaning of a serious fall to independently residing older adults. A qualitative phenomenological approach was utilized with a purposive sample of 19, independent, high-level functioning older adult residents of a Continuing Care Retirement Community to describe their most serious fall and its personal meaning. Traced through multiple data sources, interpretive analysis of the language expressed by older adults were integrated to support [...]

969 4351

Open Access Original Research

How Can Architectural Acoustics Reflect Levels of Stress and Relaxation in Indoor Environments? An EEG-Based Experimental Study

Received: 11 April 2025;  Published: 31 July 2025;  doi: 10.21926/obm.neurobiol.2503294

Abstract

The acoustic design of indoor environments encompassing spatial configuration, material properties, and sound absorption significantly influences auditory perception and psychological well-being. This study examines the interaction between architectural acoustics, musical stimuli, and neural responses within a controlled therapeutic context, focusing on their effects on stress reduction and relaxation. Electroencephalography (EEG) was utilized to measure brain activity in 24 participants exposed to six musical inst [...]

1470 8936

Open Access Original Research

Protective Effects of Teucrium polium Extract Against LPS-Induced Oxidative Stress in BV-2 Microglia: Insights from Wild-Type and Acox1⁻/⁻ Models

Received: 20 May 2025;  Published: 30 July 2025;  doi: 10.21926/obm.neurobiol.2503293

Abstract

Microglial activation and the associated oxidative or inflammatory responses play a crucial role in the development of neurodegenerative diseases. In this study, we evaluated the antioxidant, cytotoxic, and anti-inflammatory properties of Teucrium polium (TP) ethanolic extract in murine BV-2 microglial cells, including wild-type (Wt) and peroxisomal β-oxidation-deficient Acox1-/- cell lines. The TP extract exhibited high antioxidant activity as assessed via the DPPH test, with an IC50 value of 73.89 μ [...]

747 3804

Open Access Perspective

Performance Art as Lifestyle: Art in Action for Health Promotion

Received: 11 May 2025;  Published: 28 July 2025;  doi: 10.21926/obm.icm.2503033

Abstract

Performance art is both a visual arts practice and kinaesthetic approach to place-based health. The perspective of this commentary is to promote the attributes of performance art to showcase its capacity to extend people into new configurations of cultural engagement with beneficial effects. Performance art is an opportunity to engage both mind and body in actions that transform predictability and encourage wellness within the context of people’s life studios (their everyday lives). Wellness is defined here in rela [...]

705 3988

Open Access Original Research

Germination-Induced Starch Influence on Structural Characteristics of Water-Soluble Extracts from Purple Pericarp Creole Corn

Received: 14 October 2024;  Published: 28 July 2025;  doi: 10.21926/rpn.2503015

Abstract

Germination is a viable, cost-effective, and environmentally friendly biotechnological process that enhances the industrial applications of cereals. This study evaluated the impact of germination (86 hours at 30°C) on soluble solids, proximate composition, and total phenolic compounds (TPC) in water-soluble extracts. It also included imaging analyses using scanning electron microscopy (SEM), X-ray diffraction (XRD), apparent amylose content, and starch pasting properties of purple pericarp Creole corn (PPCC) fr [...]

1124 4790

Open Access Review

An Overview of Circular Economy Approaches for Plastics

Received: 28 February 2025;  Published: 28 July 2025;  doi: 10.21926/rpm.2503011

Abstract

Plastic pollution has received worldwide attention due to its extensive environmental and health implications. The circular economy has emerged as a potential solution to plastic pollution. This overview comprehensively presents different plastic circular economy approaches and discusses their advantages, disadvantages, and implementation challenges. It highlights that the current plastic circular economy approaches primarily comprise mechanical recycling, chemical recycling, bio-based and biodegradable plastics, e [...]

3439 30318

Open Access Review

Evidence-Based Rapid Review of Clean Cooking: Lessons for Nigeria and Other Developing Economies

Received: 08 December 2024;  Published: 25 July 2025;  doi: 10.21926/aeer.2503027

Abstract

Biomass-fuel use by over 2 billion of the world’s population contributes to their poor respiratory health and climate change. This paper traces the history of clean cooking and explores strategies for its sustained adoption in developing countries, such as Nigeria, drawing on global lessons from past successes and failures. This study employed a rapid review methodology to synthesize evidence and inform decision-making on the adoption of clean cooking. The research was guided by a central question on how to p [...]

2180 12188

Open Access Original Research

Attenuation of Blood Glucose by the Ketone Monoester (R)-3-betahydroxybutyrate Glyceride in Healthy Male Sprague Dawley Rats in Response to a Standard Oral Glucose Tolerance Test

Received: 31 January 2025;  Published: 25 July 2025;  doi: 10.21926/rpn.2503014

Abstract

Efficient glucose uptake by peripheral tissue is important for individuals who desire to maintain optimal wellbeing. Various methods to regulate postprandial blood glucose have been reported in the research literature, however, few have examined the effect of ketone esters on blood glucose levels. The present study evaluated blood glucose following the administration of an oral glucose tolerance test, with and without ketone esters delivered at two different dosages, in a sample of healthy Sprague-Dawley rats. We h [...]

1263 6712

Open Access Original Research

Effects of Plastoquinone Derivative 10-(6'-Plastoquinonyl) Decyltriphenylphosphonium on Rice Seeds Grown under Complete Flooding Conditions

Received: 20 February 2025;  Published: 22 July 2025;  doi: 10.21926/obm.genet.2503305

Abstract

The present work aimed to study the effects of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) on rice (Oryza sativa) plants germinating under flooding conditions. The influence of different concentrations of SkQ1 (mitochondria-targeted antioxidant) on resistance to complete flooding was assessed on rice seedlings of the Kuboyar variety. The total level of reactive oxygen species (ROS), H2O2-induced chemiluminescence, and gene expression of antioxidant enzymes (OsSODA (superoxide dismutase A), OsSODB (s [...]

833 3813

Open Access Review

Integrating Neuroimaging, Biomarkers, and Rehabilitation Strategies for Optimized Diagnosis and Recovery in Traumatic Brain Injury

Received: 28 February 2025;  Published: 21 July 2025;  doi: 10.21926/obm.neurobiol.2503292

Abstract

This review examines a multimodal approach that integrates advanced neuroimaging, biofluid biomarkers, and innovative rehabilitation strategies for the optimized diagnosis and recovery of traumatic brain injury (TBI). TBI remains a critical public health challenge due to its high incidence and diverse, long-lasting morbidities. Conventional diagnostic methods often lack the sensitivity to detect subtle injuries, and current prognostic models are limited by the heterogeneity of TBI. Emerging neuroimaging techniques, [...]

2235 10489

Open Access Short Report

Donor-Derived Cell-Free DNA Assessment in a Predominantly Hispanic/Latino Lung Transplant Population: Single-Center Analysis

Received: 31 March 2025;  Published: 21 July 2025;  doi: 10.21926/obm.transplant.2503254

Abstract

The demographics of lung transplant (LT) recipients show an evolution towards increased minority racial/ethnic representation, thanks to an increased focus on inclusion in LT access, healthcare and outcomes. Herein we assess potential differences in LT allograft health in a predominantly Hispanic/Latino (HL) vs Non-Latino/White (NLW) cohort during surveillance for acute rejection by analyzing the fraction of donor-derived cell-free DNA (dd-cfDNA%), a plasma biomarker of allograft injury. Of 245 LT recipients, media [...]

811 3695

Open Access Original Research

The Multiple, Embodied Positive Effects of a Community-Based Aerial Sling Class: Improved Body Schema, Fitness, Mental Health, and Diet

Received: 06 April 2025;  Published: 17 July 2025;  doi: 10.21926/obm.icm.2503032

Abstract

Contrary to the dominant ultra-cognitive approach in public health whereby only thought processes are supposed to link to action (e.g., physical activity) and health, in this research an embodied (body-mind unison) philosophy was examined by showcasing the importance of holistic and performative movement experiences to health and well-being. Specifically, the purpose of this study was to comprehensively examine the interrelated, multiple, and embodied benefits of a community-based aerial sling class (“Flow”) on bod [...]

1044 5234

Open Access Review

An Exploration of the Psycho-Social Factors that Impact the Mental Wellbeing of Unaccompanied Asylum-Seeking Children in UK: A Narrative Review

Received: 23 January 2025;  Published: 17 July 2025;  doi: 10.21926/obm.icm.2503031

Abstract

Unaccompanied asylum-seeking children (UASC) are amongst the most vulnerable populations worldwide, facing significant psycho-social and mental health challenges influenced by pre-migration, migration, and post-migration experiences. This narrative review examines the structural, legal, and practical factors affecting UASC, focusing on their lived experiences within the UK’s asylum system. Key areas explored include trauma caused by forced migration (pre-, during and post-migration), ethical dilemmas surrounding ag [...]

719 5031

Open Access Review

Leveraging DNA Databases to Reconnect Families Separated by Conflicts and Humanitarian Crises

Received: 14 May 2025;  Published: 15 July 2025;  doi: 10.21926/obm.genet.2503304

Abstract

Ongoing global conflicts and humanitarian crises have led to unprecedented displacement, including millions of separated children, many of whom, especially infants, cannot be traced using traditional methods. This paper advocates for the establishment of a voluntary, privacy-protected global DNA database, managed by an extra-governmental entity, to facilitate family reunification. It presents a comprehensive socio-technical framework that synthesizes a novel operational model with the requisite legal and ethical sa [...]

1122 5487

Open Access Original Research

Treatment of Contaminated Water Collected from River Getsi Using Enhanced Natural Coagulant Prepared from Chrysophyllum Albidium Seeds

Received: 31 March 2025;  Published: 15 July 2025;  doi: 10.21926/aeer.2503026

Abstract

The high cost of chemical coagulants for water treatment leads most people in rural communities to resort to readily available surface water, which is usually of low quality, exposing them to various waterborne diseases. It is in this light, that research was conducted to assess the effectiveness of a cheap enhanced natural coagulant prepared from Chrysophyllum albidium seeds for the treatment of contaminated water sampled from River Getsi, which serves as a source of potable water for the society. The coagulants s [...]

1158 4460

Open Access Original Research

Impact of Normalization Methods on Metagenomic Characterization of Amaranthus Cruenthus var. Pribina-Associated Microbiomes Under Cadmium Stress

Received: 17 January 2025;  Published: 15 July 2025;  doi: 10.21926/obm.genet.2503303

Abstract

The study of endophytic and rhizosphere microbiota offers considerable potential for applications in agriculture, biotechnology, and bioremediation, given the phytoremediation capacity of Amaranthus cruentus var. Pribina performed a detailed analysis of the root and rhizosphere microbial communities under cadmium (Cd) stress. Although metagenomics provides powerful tools for microbial community profiling, the reproducibility and interpretability of the results are strongly influenced by the data processing strategi [...]

1259 4287

Open Access Original Research

Air Pollution Control Engineering in Urban and Congested Areas

Received: 04 February 2025;  Published: 11 July 2025;  doi: 10.21926/aeer.2503025

Abstract

The study aims to evaluate the progressive increase in energy systems pollutant emissions due to the efficiency loss and continuous deterioration in the energy conversion process. The paper analyzes the GHG, nitrous oxide, sulfur dioxide, and fine particle emissions from vehicles, residential and commercial heating systems, public buildings, health centers, and industrial conglomerates, with the servicing time and degradation level. The analysis applies to various emitting gases or small particle systems, which gen [...]

1151 4521

Open Access Editorial

Frank Bahr – A Life Dedicated to Energy Medicine-- In Memory of Prof. Dr. Frank Bahr (1944–2025)

Received: 07 July 2025;  Published: 10 July 2025;  doi: 10.21926/obm.icm.2503030

Abstract

With the passing of Prof. Dr. Frank Bahr, the field of complementary medicine has lost one of its most influential personalities. As a pioneer of auricular medicine in the German-speaking world, he helped shape the field of integrative medicine over many decades. This tribute by Prof. DDr. Gerhard Litscher honors Bahr's work, his convictions, and the legacy of a visionary whose impact on energy and spiritual medicine endures.

883 4638

Open Access Editorial

Catalysis for Biomass Conversion: Pioneering Emission Control and Sustainable Energy Futures

Received: 08 July 2025;  Published: 10 July 2025;  doi: 10.21926/cr.2503006

1569 5744

Open Access Review

Astrocyte-Neuron Interactions in the Neuroinflammatory Cascade of Traumatic Brain Injury

Received: 31 March 2025;  Published: 09 July 2025;  doi: 10.21926/obm.neurobiol.2503291

Abstract

Traumatic brain injury (TBI) is a significant public health concern, leading to substantial morbidity and mortality. While the primary injury is mechanical, the subsequent neuroinflammatory cascade plays a critical role in secondary injury and long-term neurological deficits. Astrocytes, the most abundant glial cells in the brain, play a key role in this cascade, interacting with neurons in a complex interplay that can both protect and exacerbate neuronal damage. This paper aims to provide a comprehensive overview [...]

1262 7045

Open Access Research Article

Lanthanum Uptake and Distribution in Agricultural and Wild Plants: Insights from Greenhouse and Field Studies in Uncontaminated Soils

Received: 24 March 2025;  Published: 08 July 2025;  doi: 10.21926/rpse.2503012

Abstract

Lanthanum (La) is widely used in various fields. As a consequence, it can accumulate in soil and thus pose a potential hazard to the environment, including a decrease of plant biomass and chlorophyll content. To date, most experimental studies on the biogeochemistry of La have focused on toxic effects resulting from its accumulation in plants growing in La-contaminated areas, while the behavior of La in plants growing in uncontaminated soils has been the subject of much less research. The primary objectives of this [...]

1561 5577

Open Access Original Research

Evaluation of Polylocus Spectra of DNA Fragments of the Genus Eguus Using ISSR-PCR Markers

Received: 16 April 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503302

Abstract

Characterization of the non-coding part of the transcriptome is a supplement to the annotation of the genome of living organisms. According to ISSR-fingerprinting data, information is obtained about ancient gene pools, modern gene pools, genetic variability and conservation of breeds and species of farm animals. The aim of the study is to study the molecular genetic component and phylogenetic relationships in the aboriginal Hutsul horse breed and fossil remains of ancient horses using ISSR-PCR markers. The polymorp [...]

815 3682

Open Access Original Research

Serum Shock Enhances Endogenous Melatonin Production and Mitochondrial Gene Regulation in U87-MG Glioblastoma Cells

Received: 14 March 2025;  Published: 07 July 2025;  doi: 10.21926/obm.genet.2503301

Abstract

Glioblastoma (GBM) is the most aggressive primary brain tumor, with a poor prognosis despite advancements in understanding its biology. Melatonin, a key regulator of metabolism and cellular homeostasis, is known for its neuroprotective and anti-cancer properties. While traditionally linked to pineal gland secretion, emerging evidence suggests that glioblastoma cells can produce melatonin within their mitochondria. This study investigates whether serum shock can influence endogenous melatonin production and mitochon [...]

1056 4658

Open Access Original Research

Exploring the Practice of One-to-One Therapeutic Viniyoga: A Qualitative Investigation Using Interpretative Phenomenological Analysis and Directed Content Analysis

Received: 07 April 2025;  Published: 03 July 2025;  doi: 10.21926/obm.icm.2503029

Abstract

Therapeutic Viniyoga is holistic and the treatment, starting point, progression, and goals are unique for each individual client. This study uses Interpretative Phenomenological Analysis (IPA) and directed content analysis, combining theory and application to offer a tangible, conceptually grounded window into the process and practice of one-to-one Therapeutic Viniyoga. How Viniyoga is applied therapeutically is explored through the lens of trained Viniyoga therapists. Fourteen Viniyoga therapists were interviewed, [...]

1140 5664

Open Access Original Research

Natural Neurostimulation for Chronic Pain Management: A Case Series of 3 Patients with Dysmenorrhea and Menstrual Migraine

Received: 09 February 2025;  Published: 03 July 2025;  doi: 10.21926/obm.neurobiol.2503290

Abstract

Accumulating evidence suggests that chronic pain occurs in various disorders due to correlated processes of spontaneous cortical reorganization and dysregulation of cortical excitability in consciousness-related networks. This case series tracks three patients with chronic pain associated with the menstrual cycle treated by a novel non-invasive brain stimulation technique that applies qualities of the mother-fetus neurocognitive model. Previous research has shown that a low-frequency pulsed electromagnetic field an [...]

1080 6180

Open Access Original Research

Gut Microbial Similarity Analysis in Mono and Dizygotic Twins Discordant for Down Syndrome

Received: 05 October 2024;  Published: 03 July 2025;  doi: 10.21926/obm.genet.2503300

Abstract

To investigate the potential impact of the additional chromosome 21 on the gut microbiome in patients with Down syndrome (DS), two monozygotic (MZ) and two dizygotic (DZ) twin pairs discordant for DS were studied. Whole-genome shotgun sequencing was conducted to analyze the taxonomic and functional profiles of the gut microbial community in the twins and assess whether the gut microbiome composition influences the development of psychological pathologies. Sequencing generated a total of 2,338,132 reads, combined ac [...]

832 4647

Open Access Interview

An Interview with Dr. Pietro Gareri

Received: 02 July 2025;  Published: 02 July 2025;  doi: 10.21926/obm.geriatr.2503318

808 2848

Open Access Editorial

Catalysis, Meet the Machine: From Models to Meaning

Received: 25 June 2025;  Published: 27 June 2025;  doi: 10.21926/cr.2502005

1116 4943

Open Access Review

Fall Prevention Knowledge and Attitude Tests-Surveys Used by Staff and Nurses: A Systematic Review of Current Literature

Received: 01 February 2025;  Published: 26 June 2025;  doi: 10.21926/obm.geriatr.2502317

Abstract

Falls are a serious global public health issue affecting individuals of all ages, resulting in serious injuries, fatalities, and extended hospital stays. While knowledge and attitude of healthcare staff toward fall prevention are understood to impact patient safety, less well known are the type and content of fall prevention surveys used to identify nurses’ knowledge of fall prevention. Until now, no study has systematically reviewed the universe of existing tests, surveys, and programs used to assess fall pr [...]

1589 10250

Open Access Original Research

Intensive Cognitive Behavioral Therapy for School Avoidance among Youth with Anxiety Disorders or OCD in the COVID-19 Pandemic

Received: 27 January 2025;  Published: 26 June 2025;  doi: 10.21926/obm.icm.2502028

Abstract

School avoidance is associated with a range of negative outcomes and has been increasing in youth in the past several decades. This study examined the efficacy of an intensive outpatient CBT program, for youth (N = 137, ages 8-19) with anxiety disorders or obsessive-compulsive disorder (OCD) and compared both baseline symptoms and outcomes for youth with school avoidance compared to those without. At admission, results indicated that parents of children with school avoidance reported higher levels of family accommo [...]

910 7044

Open Access Original Research

The Identification and Classification of Novel Genetic Variants in the MCPH1 Gene Suggest Association with Non-Syndromic Hearing Impairment

Received: 16 January 2025;  Published: 26 June 2025;  doi: 10.21926/obm.genet.2502299

Abstract

Human mouse orthologous hearing impairment genes were investigated in African patients for causal variants. A homozygous mutation in exon 13 of the microcephalin1 (MCPH1) gene, which encodes the BRCA1-carboxyl terminal 2 domain (BRCT2), was reported in non-syndromic hearing impairment (NSHI). The present study aims to investigate further the emerging roles of MCPH1 in the genetics of NSHI in African patients in the new and larger cohorts. This study screened multiplex families and isolated cases, including 90 patie [...]

880 4197

Open Access Original Research

A New Database on Constitutional Human Ring Chromosomes

Received: 20 April 2025;  Published: 26 June 2025;  doi: 10.21926/obm.genet.2502298

Abstract

Human ring chromosomes (RCs) constitute one of the rarest described inborn chromosomal rearrangements. At first, they seem to be just another subgroup of structural chromosomal aberrations like translocations, inversions, or insertions. However, RCs are more complex, as they almost always occur in conjunction with a mosaic karyotype constitution, resulting in mosaic monosomy of the affected chromosome. Most likely due to the latter effect, a genotype-phenotype correlation is still not available. To proceed with sol [...]

836 5113

Open Access Research Article

In Silico Evaluation of Bioactive Compounds (Flavonoids, Rosmarinic Acid) from Five Plants (Rosemary, Oregano, Pink Savory, Lemon Balm, and Saffron) and Their Role in Cardiovascular Health and Hypertension

Received: 22 January 2025;  Published: 25 June 2025;  doi: 10.21926/obm.icm.2502027

Abstract

Cardiovascular diseases and hypertension represent significant global health challenges, driving the need for innovative therapeutic solutions. In this study, we employed advanced in silico methods to investigate the molecular properties of two bioactive compounds, Flavonoids and Rosmarinic Acid, extracted from five medicinal plants: Rosemary, Oregano, Pink Savory, Lemon Balm, and Saffron. The bioactive compounds were evaluated against key biological targets associated with hypertension and cardiovascular diseases, [...]

1413 10120

Open Access Case Report

Papillon-Lefèvre Syndrome and Vitamin D Deficiency: An Intriguing Clinical Observation

Received: 06 April 2025;  Published: 24 June 2025;  doi: 10.21926/obm.genet.2502297

Abstract

We report the case of a 3-year-old girl from a consanguineous marriage, initially diagnosed with vitamin D deficiency–associated periodontitis following early tooth mobility. Despite supplementation, her condition worsened with the onset of palmoplantar hyperkeratosis. Further investigations revealed the diagnosis of Papillon-Lefèvre Syndrome (PLS), a rare genetic disorder causing severe periodontitis and palmoplantar keratosis. The patient was managed with vitamin D supplementation, dental extractions, and a remov [...]

772 5014

Open Access Review

Comparison of Compressed Air Flow Measurement Techniques for Industrial Energy Efficiency Enhancement

Received: 31 October 2024;  Published: 24 June 2025;  doi: 10.21926/aeer.2502024

Abstract

Across the industrial sector, compressed air is utilized as an easy-to-use and readily accessible tool in a variety of applications. This tool is commonly misunderstood as being more efficient than it is in reality. Air compression is energy intensive and thus both economically and environmentally costly. Compressed air typically only achieves around ~15% efficiency if judged by the energy delivered from the air, meaning approximately 5-6 kWh are wasted for every 1 kWh of useful work performed by compressed air. Du [...]

1638 9560

Open Access Research Article

Modeling the Mesoscopic-Scale Spatial Evolution of the Epileptic Pre-Ictal and Ictal Phases

Received: 13 December 2024;  Published: 23 June 2025;  doi: 10.21926/rpse.2502011

Abstract

The spatial evolution of the epileptiform regime in neural networks can be alternatively described in terms of a statistical approach, dealing with average smooth, differentiable fields rather than discrete neural elements. After a brief review of mathematical methods for modeling epilepsy (the condensed matter vs. the neural mass models) together with their pros and cons, we introduce our continuous-space model for the pre-ictal scalar field and the ictal epileptiform vector flux in the form of the diffusion equat [...]

1069 4329

Open Access Original Research

Barriers and Facilitators to Meditation: Empirical Research Qualitative

Received: 13 March 2025;  Published: 23 June 2025;  doi: 10.21926/obm.icm.2502026

Abstract

This study aims to investigate the barriers and facilitators to meditation in the general population. This research is significant because understanding these factors can inform the design of more effective public mental health interventions and support the integration of meditation into daily life. A qualitative thematic analysis was conducted on the qualitative component of wider survey responses. Participants were recruited from MeditationHQ, which offers weekly group meditation sessions on beaches around Austra [...]

2076 9041

Open Access Interview

An Interview with Dr. José Pinela

Received: 22 June 2025;  Published: 23 June 2025;  doi: 10.21926/rpse.2502010

687 6044

Open Access Review

Lignocellulosic Biomass and Enzymes: Fundamentals, Emerging Technologies, and Applications

Received: 25 January 2025;  Published: 19 June 2025;  doi: 10.21926/cr.2502004

Abstract

Lignocelluloses are complex plant polysaccharides made of lignin, cellulose, and hemicellulose, and products made from these components find immense market potential. They can be effectively valorized to products related to bioenergy, bioplastics, food and nutrition, medication delivery systems, and other elements. Significant sources of lignocellulosic biomass include sugarcane bagasse, corn cob, rice straw, potato haulms, cocoa pods, etc. Enzyme-based valorization processes find immense potential, as they are eco [...]

1720 12479

Open Access Case Report

Checkpoint Inhibition Followed by CAR-T Cell Therapy in Refractory PMLBCL: Immunologic Response and Fertility Preservation in a Young Patient

Received: 22 February 2025;  Published: 18 June 2025;  doi: 10.21926/obm.transplant.2502253

Abstract

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive B-cell malignancy that may exhibit resistance to standard chemoimmunotherapy. Novel immunotherapeutic strategies, including checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy, are being explored in cases that are refractory to treatment. We report the case of a 29-year-old patient with refractory PMLBCL who was treated with pembrolizumab as a bridging therapy followed by axicabtagene ciloleucel (CAR-T) after failing R-CHOP a [...]

869 4090

Open Access Review

Physicality of Spirituality: The Interplay of the Autonomic Nervous System, Prefrontal Cortex, and Spiritual Life in Light of Galatians 5:16-25

Received: 04 March 2025;  Published: 18 June 2025;  doi: 10.21926/obm.icm.2502025

Abstract

This article examines the complex relationship between the autonomic nervous system, the prefrontal cortex, and spiritual life, providing an interdisciplinary analysis in light of Galatians 5:16-25. Through a combination of theological reflection and insights from neuroscience, it explores how spiritual practices, such as meditation and prayer, influence emotional regulation, impulse control, and overall well-being. Studies in neuroscience have shown that regular spiritual practice can lead to measurable changes in [...]

873 11512

Open Access Editorial

In the Mirror of the Past, in the Light of the Future: The ISLA – A President Looks Back and Forward

Received: 15 June 2025;  Published: 18 June 2025;  doi: 10.21926/obm.icm.2502024

Abstract

This editorial for the 27th ISLA Congress in Beverungen in Germany reflects on the development, achievements, and challenges of the International Society for Medical Laser Applications (ISLA-transcontinental) from the perspective of its President for Science and Research, Univ.-Prof. DDr. Gerhard Litscher. It reviews the organization’s milestones and growth while outlining future strategies for innovation, research, and international collaboration in medical laser technologies. The full keynote presentation is avai [...]

1444 5126

Open Access Original Research

Modern UNOS Data Reveals Septuagenarians Have Inferior Heart Transplant Survival

Received: 10 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.transplant.2502252

Abstract

While heart transplantation is increasingly performed in the United States for elderly patients, survival outcomes have primarily been analyzed in single-center studies. The few existing long-term studies have indicated no difference in HTx outcomes between patients ≥70 years and 60-69 years age, but these studies only assessed to 5-years post-transplant and included data from the 1980-90s, introducing significant variance due to poorer outcomes in that era. We analyzed the UNOS database from 1987-2020, stratified [...]

993 4737

Open Access Original Research

Dependence Levels and Oral Functionality in Older People

Received: 03 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.geriatr.2502316

Abstract

It has been suggested that an individual's overall functional capacity gradually declines with age. It has been reported that a decline in oral functionality increases the risk of sarcopenia and frailty, which contributes to the decrease in functional capacity. In Chile, the Preventive Medical Examination for Older Adults (EMPAM) is used to assess the functionality of that population; however, this examination does not include an evaluation of oral functionality. To address this gap, the Preventive Dental Examinati [...]

1151 4283

Open Access Review

Chemical Neuroscience of Heterocyclic N-Amines: Implications for Pain Management, Mental Health, and Opioid Withdrawal

Received: 05 December 2024;  Published: 10 June 2025;  doi: 10.21926/obm.neurobiol.2502289

Abstract

This study reviews the biochemical mechanisms and clinical implications of N-heterocyclic amine drugs, particularly in the context of pain management, mental health, and opioid withdrawal. It highlights the structural diversity and receptor binding capabilities of these compounds, which enable them to target the nervous system and cross the blood-brain barrier effectively. The article discusses the role of opioids in pain relief, detailing their agonistic effects on opioid receptors and the subsequent risk of addic [...]

1327 7857

Open Access Original Research

Reciprocal Translocations in Prenatal Diagnosis: Latin America Data

by Luis A. Méndez-Rosado  , Luis A. Sotillo-Bent  , José Sotillo-Lindo  , Anduriña Barrios-Martínez  , Dulce Hechavarria-Estenoz  , Margarita Mayeta  , Jose Hernández-Gil  , Hector Pimentel-Benitez  , Maria Elena de la Torre  , Hibo Moreno  , Pedro Díaz-Véliz  , Alicia Vaglio  , Roberto Quadrelli  , Diana Sánchez-Peñarate  , Mabel Cerrillo-Hinojosa  , Pedro Carbonell-de la Torre  , Judith Pupo-Balboa  , Michel Soriano-Torres  , Marilyn del Sol  , Arlay Castelvi  , Enny Morales  , Damarys García  , Rocío Serrano-Hidalgo  , Catalina Obando  , Liz Pardo  , Laritza del Toro  , Miladys Martinez  , Conrado Uria-Gómez  , Maria G Arteaga Ontiveros  , Mayte Castro  , Odalys Rabelo  , Sahily Miñoso  , Deysi Licourt  , Irenia Blanco  , Roberto Lardoeyt-Ferrer  , Nereida Gonzalez  and Olga Quiñones-Masa
Received: 24 November 2024;  Published: 10 June 2025;  doi: 10.21926/obm.genet.2502296

Abstract

Generally, in reciprocal translocations there are no gains or losses of genetic material. From the clinical point of view, its primary importance lies in the fact that it can generate errors due to incorrect chromosome segregation during meiosis in carriers. On the other hand, other mutations are less frequent in the genome, specifically in the DNA breakpoints implied in these translocations. In Latin America there are no large-scale reports about this topic. To contribute to the study of reciprocal translocations [...]

1367 6803

Open Access Review

Integrating RNA-Seq Biomarkers and Diagnostic Algorithms to Improve Liver Transplant Outcomes: A Comprehensive Review

Received: 21 February 2025;  Published: 09 June 2025;  doi: 10.21926/obm.transplant.2502251

Abstract

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as liver biopsies and liver function tests (LFTs), often fail to identify abnormalities early and with accuracy. Genomic RNA sequencing (RNA-Seq) has recently emerged as a powerful approach for identifying molecular markers o [...]

1514 9298

Open Access Original Research

The Effect of the Levonorgestrel-Releasing Intrauterine Device on Hypoactive Sexual Desire Disorder in Women

Received: 28 December 2024;  Published: 06 June 2025;  doi: 10.21926/obm.icm.2502023

Abstract

This research focused on the evaluation of the relationship between the levonorgestrel-releasing intrauterine device and Hypoactive Sexual Desire Disorder in women. Sexual desire disorder is part of a group of sexual dysfunctions. A group of 60 women with a diagnosis of hypoactive sexual desire were tested in the period from July 2023 to July 2024 at the Institute of Sexology of the 1st Faculty of Medicine in Prague. These patients were examined for levels of prolactin, sex hormone binding globulin, total testoster [...]

708 8297

Open Access Review

Mechanisms of Action of Ready-to-Use Therapies in Hematologic Malignancies: From Clinical Impact to Future Directions

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Abstract

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global acces [...]

1001 4316

Open Access Research Article

Physicochemical Characterization of Fresh and Powdered Tomato in Arba Minch, Ethiopia

Received: 07 January 2025;  Published: 02 June 2025;  doi: 10.21926/rpn.2502013

Abstract

Tomato (Solanum lycopersicum L.) is the largest vegetable crop produced and consumed in the world. Tomatoes are a top source of Vitamin A and C, contain more dietary fibre, beta-carotene, iron, lycopene, magnesium, niacin, potassium, phosphorus, riboflavin, and thiamine. Tomatoes have a limited shelf life in ambient conditions and are highly perishable. It creates glut during the production season and becomes scanty during the off-season. Short shelf life, coupled with inadequate processing facilities results in he [...]

1645 7876

Open Access Review

Locked Plating Versus Retrograde Intramedullary Nailing in The Surgical Fixation of Periprosthetic Supra-condylar Knee Fractures: An Updated Systematic and Meta-Analysis Review

Received: 25 November 2024;  Published: 02 June 2025;  doi: 10.21926/obm.geriatr.2502315

Abstract

Meta-analysist to evaluate impact of Surgical Methods on Outcomes in periprosthetic supracondylar knee fracture management. This study examines the rate of functional outcomes and complications associated with two distinct surgical methods for the management of periprosthetic supracondylar knee fractures in patients treated with Low Contact Locking Plates (LCP) and Retrograde Intramedullary Nails (RIMN). With the growing prevalence of total knee replacements, the incidence of periprosthetic supracondylar knee fract [...]

1083 7878

Open Access Review

Overview of Practical Applications of Healthcare Ethics for Older Adults

Received: 30 January 2025;  Published: 30 May 2025;  doi: 10.21926/obm.geriatr.2502314

Abstract

Identifying and addressing ethical issues in the care of older adults can be complex and challenging in clinical settings. This article reviews specific ethical principles including autonomy, beneficence, non-maleficence, dignity, and justice, and explores them in the context of interprofessional geriatric care. Situations and related ethical components such as treatment in intensive care units, end-of-life care, dementia care, and aging with advancing technology are included. Case scenarios for each principle or s [...]

3446 24656

Open Access Case Report

An Unusual Presentation of Pleural Effusion in an Elderly Woman Post-COVID-19 Infection: A Case Report

Received: 18 February 2025;  Published: 29 May 2025;  doi: 10.21926/obm.geriatr.2502313

Abstract

Pleural effusions are defined as accumulations of fluid in the pleural cavity surrounding the lungs. They are often secondary outcomes of underlying conditions, such as congestive heart failure, malignancy, or pneumonia. Acute cases of COVID-19 pneumonia have been linked to episodes of pleural effusion, but these cases are often rare. In this report, we analyze a case of pleural effusion in a 71-year-old female patient who had been declining after a recent COVID-19 infection and later died in the hospital. It is no [...]

1191 6116

Open Access Case Report

Best Care for the Dying, Right Plan at the Right Time: A Case Report

Received: 31 January 2025;  Published: 28 May 2025;  doi: 10.21926/obm.geriatr.2502312

Abstract

The growing number of individuals with palliative care needs has led to an increased demand for specialized palliative care teams.. However, these teams often struggle to meet the demand, requiring all nurses to recognize and provide appropriate care during a patient’s last hours and days of life (LHDL). This case report aims to highlight the importance of identifying the LHDL and implementing individualized and adjusted care plans based on the 10/40 model of care. A descriptive-reflective case report following the [...]

1141 4760

Open Access Research Article

Development of Parametric Voronoi-Based Scaffolds for Trabecular Bone Tissue Replacement Using Additive Manufacturing

Received: 07 February 2025;  Published: 28 May 2025;  doi: 10.21926/rpm.2502010

Abstract

Tissue engineering is a technique for regenerating living tissue using portions of the patient's tissue, which are dissociated into cells and cultured on biological or synthetic supports before being transferred to the patient. In this context, the present study seeks to develop implant models (scaffolds) for replacing trabecular bone tissue, with requirements such as porosity and interconnected pores. All design development was aimed at the manufacturing of scaffolds using the material extrusion additive manufactu [...]

1393 7396

Open Access Review

Emerging Progress in Nanotechnological Influence on Polymeric Textile Finishing

Received: 13 January 2025;  Published: 27 May 2025;  doi: 10.21926/rpm.2502009

Abstract

Nanotechnology has revolutionized the textile industry by introducing innovative finishing techniques that enhance the durability and performance of textile materials and the application of nanoscale/nanoparticles/nanomaterials and processes to improve the properties and performance of textiles. The synergism of textile technology and nanotechnological advancements has propelled a paradigm shift, changed the narrative, and formed novel platforms for textile surface engineering at both atomically affiliated and mole [...]

2841 22175

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