by Yossi Ehrenreich

Received: 17 May 2022;  Published: 06 February 2023;  doi: 10.21926/obm.icm.2301012

This paper aims to introduce a relatively novel approach for Hypnosis to treat Depersonalization-derealization Disorder (DPRD). Depersonalization is conceptualized as a disrupted interoceptive process disorder. Based on this conceptualization, Hypnotic intervention is tailored to counter the flawed process. It is exemplified by a case of a young man suffering from depersonalization disorder who couldn't bear looking at himself in the mirror. The hypnotic intervention used in this case is then explained by predictiv [...]

by Niccolò Castellani Nicolini  , Jacopo Belfiore  and Giandomenico Biancofiore

Received: 14 May 2023;  Published: 13 October 2023;  doi: 10.21926/obm.transplant.2304198

Liver transplantation (LT) is a life-saving treatment representing the only viable option for patients suffering from end-stage liver disease (ESLD) or acute liver failure. Patients who undergo LT require a multidisciplinary approach to postoperative pain management. However, pain management in this context is often inadequately explored. Limited options exist for proper pain control in patients with hepatic failure, mainly due to the increased risk of kidney and multi-organ failure. In LT candidates, specific anal [...]

by Renate Verkaik  , Iris van der Heide  , Eugenie van Eerden  , Peter Spreeuwenberg  , Erik Scherder  and Anneke L. Francke

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.geriatr.1904092

Background: Studies conducted on the effectiveness of psychosocial interventions have indicated that sensory stimulation represents a promising approach to reduce the psychological and behavioral disturbances in people with dementia. Multi-sensory stimulation involves the simultaneous stimulation of multiple senses, through the use of various methods, for example, by using a variety of lights, gentle stimulating music, aromas, and tactile objects, among others. A relatively novel approach is the enriched thematic m [...]

by Muhammad Ismail

Received: 09 November 2022;  Published: 15 March 2023;  doi: 10.21926/cr.2301014

Silver nanoparticles have been utilized in an easy, sensitive, and effective approach through spectrophotometry and spectrofluorimetry to quantify urea in water samples. Here, 1,3-di-(1H-imidazole-1-yl) -2-propanol (DIPO) was employed to stabilize Ag NPs produced from the reduction of aqueous silver nitrate by sodium borohydride (NaBH4). Beer-Lambert's law was applied for determination using the complexation of Ag NPs with urea molecules. The results show urea can be assessed concurrently with good results and perc [...]

by Vincenzo Prisco  , Bernadette Donnarumma  and Lorenzo Prisco

Received: 02 December 2022;  Published: 22 March 2023;  doi: 10.21926/obm.geriatr.2301228

This paper discusses the history and the concept of somatization from masked depression to somatic symptoms and related disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM). Evaluating the evolution of these terms and concepts along the time course is very interesting. DSM 5 revision was intended to increase the relevance of these concepts in the primary care setting. “Masked depression” is a form of depression in which somatic symptoms or behavioral disturbances dominate the clinical pictur [...]

by Rui Wang  , Omar M. Basha  , Husain E. Ashkanani  , Bingyun Li  and Badie I. Morsi

Received: 19 August 2024;  Published: 21 November 2024;  doi: 10.21926/jept.2404022

CO2 capture processes using five chemical solvents were modeled in Aspen Plus V.12.1 for the capture of over 90% CO2 from a 456 ton/hour split flue gas stream containing 12.02 mol% CO2 emitted by the Longview 780 MW power plant (West Virginia, USA). Since the flue gas contained 33.10 ppmv SO2 and 35.47 ppmv NO2, a gas polishing process, using deionized water (DIW), was included in the model for complete scrubbing of SO2 and NO2 from the raw flue gas before the CO2 capture process. The five chemicals used for CO2 ca [...]

by K. Jason Crandall  , Matthew Shake  and Uta Ziegler

Received: 11 April 2019;  Published: 04 July 2019;  doi: 10.21926/obm.icm.1903041

Background: Older adults experience normative age-graded declines in physical and cognitive performance and many must manage one or more chronic conditions. Exercise programs can help to improve both their physical health and their knowledge, skill, and confidence in managing aspects of their own healthcare, yet a significant barrier is motivating them to adhere to such programs. The purpose of this investigation was to evaluate the impact of a game-centered mobile app (Bingocize®) on older adults' knowledge [...]

by Igor Val Danilov  and Sandra Mihailova

Received: 09 November 2022;  Published: 28 April 2023;  doi: 10.21926/obm.neurobiol.2302167

This expanded conference paper reports the results of a psychophysiological research study on shared intentionality conducted in 24 online experiments with 405 subjects (208 recipients and 197 contributor-confederates). In this research, we created a bioengineering system for assessing shared intentionality in human groups by modeling mother-neonate dyad properties in subjects during solving unintelligible multiple-choice puzzles. In this model, only the mother (contributor-confederate) knows the correct stimulus a [...]

by Elysa Nensy Irawan  , Sandro Sitompul  , Ken-Ichiro Yamashita  and Goro Fujita

Received: 05 October 2022;  Published: 02 January 2023;  doi: 10.21926/jept.2301001

This research aims to know the effect of the Rotor Radius Ratio on the performance of the hybrid Vertical Axis Wind Turbine Savonius-Darrieus NREL S809 model using the Computational Fluid Dynamics method. Two-bladed Savonius is used as an internal rotor, and three-bladed Darrieus NREL S809 as an external rotor. Turbine model performance is analyzed through the value of the Moment Coefficient and Power Coefficient. The result shows that the increase in the Rotor Radius Ratio value causes an increase in the initial M [...]

by Trenton Cersoli  , Muneer Barnawi  , Kerry Johnson  , Edward Burden  , Frank Li  , Eric MacDonald  and Pedro Cortes

Received: 17 February 2022;  Published: 29 April 2022;  doi: 10.21926/rpm.2202009

Shape memory polymers (SMPs) are smart materials that can respond to certain thermal, chemical or electrical stimuli by inducing a structural conformation change into a temporary shape. In this work, a 3D printing process based on a Vat Photo-polymerization of a shape memory polymer (SMP) was investigated to produce customized smart and complex morphable antennas. The mechanical and material properties were examined through a tensile, flexural and rheological testing for different polymer mixture ratios. It was obs [...]

by Abdol Aziz Shahraki

Received: 18 September 2021;  Published: 17 December 2021;  doi: 10.21926/aeer.2104035

This research suggests optimal planning and designing techniques for tourism complexes in urban master planning. Firstly, it explains the importance of the tourism industry through the theories of scholars and experts. It also emphasizes the connection between the development of urban economies and the tourism industry. This helps integrate the tourism industry and comprehensive regional/urban planning. It starts with planning and designing the tourism complexes in the early stages of the municipality’s master plan [...]

by Maryanna D. Klatt  , Emaline Wise  , Olivia Gabram  , Megan Huber  , Lai Wei  and Mira Katz

Received: 02 April 2019;  Published: 11 December 2019;  doi: 10.21926/obm.neurobiol.1904047

Background: The global principles of Mindfulness-Based Stress Reduction (MBSR) have led to the creation of Mindfulness-Based Interventions (MBIs), which are interventions that retrain the mind to modify its usual stress response to increase coping and resilience. Mindfulness in Motion (MIM) is an MBI that has shown significant biologic and positive psychosocial outcomes with adult working populations, but had not previously been tested in oncology populations and their caregivers. Utilizing MIM to improve sleep qua [...]

by Ami Rokach

Received: 09 November 2022;  Published: 17 May 2023;  doi: 10.21926/obm.geriatr.2302236

Social support has been shown to have many positive effects on our lives, health, and ability to grow and flourish. Lack, or diminished social support results in loneliness. This thematic review focuses on the elderly, and the loneliness that is part of the life of many of them. The review highlights the social connections and the expectations that the elderly may have of them, and how being connected to others may alleviate, loneliness. Loneliness is known to negatively affect one’s health, social life, familial r [...]

by Amrin Ahmed  , Alixe Ménard  , Alison C Novak  , Nancy Edwards  and Sarah Fraser

Received: 27 May 2024;  Published: 28 August 2024;  doi: 10.21926/obm.geriatr.2403286

Older adults are disproportionately susceptible to hospitalizations and fatalities due to stair-related falls. While many intrinsic risk factors, such as mobility and vision, may increase the likelihood of falls on stairs, features of the stairs that increase the risk of falls are understudied. This study aimed to capture older adults’ perspectives of stair falls, as well as introduce the Safer Steps app and explore its feasibility in this population. This m-health technology was designed to gather data on st [...]

by Cynthia M.A. Geppert  and Ronald W. Pies

Received: 17 March 2020;  Published: 23 March 2020;  doi: 10.21926/obm.icm.2001016

Cultural and religious competence is an essential component of palliative and end-of-life care. Because religious, ethnic and racial groups often differ in their values and preferences, including their attitudes toward palliative and end-of-life care, clinicians must maintain an open and respectful attitude toward these differences. Cultural and religious competence can improve palliative and end-of-life care, and strengthen the therapeutic alliance with patients and their families.

by Lucy Wyatt

Received: 24 November 2020;  Published: 22 January 2021;  doi: 10.21926/jept.2101005

This paper presents the case for the use of HF radar to provide wave, current and wind measurements and maps during the surveying, resource and impact assessment, construction, maintenance and performance assessment phases of an offshore fixed or floating wind farm or other marine renewable project. The data presented are from the Celtic Sea which is currently the focus of a lot of offshore wind interest. The data are from a dual radar system deployed at the Wave Hub site off the Cornwall coast since 2011, a single [...]

by Alberto Dionigi

Received: 16 February 2018;  Published: 31 May 2018;  doi: 10.21926/obm.icm.1802009

Clowning has a varied tradition and a long history. Recently, clowns have been adopted in the medical setting with the aim of decreasing the negative emotions that can be experienced during hospitalization and medical procedures, as well as inducing positive feelings in patients, their relatives, and the hospital staff. Due to an increase in the number of clowns working in hospitals and the large amount of interest shown in utilizing this approach, an increasing number of studies have focused on testing the efficac [...]

by Rita Payan-Carreira

Received: 30 December 2018;  Published: 29 April 2019;  doi: 10.21926/obm.genet.1902074

In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the g [...]

by Parisa Gazerani

Received: 09 May 2018;  Published: 10 October 2018;  doi: 10.21926/obm.genet.1804040

Interactions between genetic and environmental factors in migraine are well known and can potentially determine an individual’s susceptibility to disease and responsiveness to treatment. Consequently, several epigenetic studies have been conducted to determine if and how genes are activated or inactivated in response to a diverse range of environmental migraine triggers. The results, in turn, have helped elucidate how these factors can promote or inhibit migraine progression or therapeutic response and can guide de [...]

by Arpitha Shankar Bandi  and Prashant Kaushik

Received: 22 March 2022;  Published: 23 May 2022;  doi: 10.21926/obm.genet.2202154

India is home to several medicinal herbs including turmeric. Turmeric is one of the major produces of India, primarily due to its unique and valuable medicinal and therapeutic properties. However, the growth and yield of turmeric are greatly affected by salt stress in certain parts of the country, especially those near water bodies where significant yield losses have been reported. To mitigate these losses caused by salt stress, certain plant breeding methods, transgenic approaches, and candidate genes along with i [...]

by Kamyar Afshar  , Michelle Bremer  , Bharath Ravichandran  , Ashley A. Feist  , Eugene Golts  , Elizabeth H. Schonhoft  and Gordon Yung

Received: 14 July 2021;  Published: 15 October 2021;  doi: 10.21926/obm.transplant.2104153

Alpha-1 antitrypsin deficiency (AATD) accounts for approximately 5% of lung transplants (LTx) performed annually. No studies have addressed the potential benefit of ongoing alpha-1 proteinase inhibitor (A1-PI) replacement to AATD patients post-LTx. Our primary objective was to assess potential benefits of continually administering A1-PI from pre- to post-transplantation for AATD LTx recipients. A retrospective case series was performed on AATD LTx recipients between 2002 and 2018. Data reviewed included date of A1- [...]

by Kenneth Lundstrom

Received: 01 October 2019;  Published: 28 November 2019;  doi: 10.21926/obm.genet.1904099

Epidemiological data and meta-analysis have confirmed that there exists a strong association between nutrition and disease risk. In the context of cancer, it has been demonstrated that unhealthy diets increase the risk of disease. On the other hand, major dietary interventions and lifestyle changes have been demonstrated to provide therapeutic efficacy in cancer patients. Genetic mechanisms have been reported to be associated with cancer development induced by environmental and nutritional factors. Genetics plays a [...]

by Aleksandra Oledzka  and Lynne Ann Barker

Received: 05 March 2019;  Published: 06 May 2021;  doi: 10.21926/obm.neurobiol.2102093

Brain training apps are becoming increasingly popular for at home use and as an adjunct to more traditional therapies. There is uncertainty about whether the effects of brain training transfer to real-world cognition, or performance on other cognitive assessment tests, or is specific only to the brain training app. Executive functions (EF’s) are higher-order cognitive processes important for activities of everyday living and autonomous goal-directed behaviour [1]. EF’s are associated with frontal brain networks tha [...]

by Tanja Radu  , Vincent Smedley  , Dipti Yadav  , Richard Blanchard  , Sheik Aminur Rahaman  , P. Abdul Salam  and Chettiyappan Visvanathan

Received: 21 September 2022;  Published: 28 November 2022;  doi: 10.21926/jept.2204039

The implementation of community-level de-centralised anaerobic digestion (AD) systems offers a sustainable solution for organic waste management and energy provision, but there is currently a need for low-cost methods of system control and management at this scale. The problem becomes accentuated with increasing deployment, as greater complexities are created by the need to both monitor and control a wider network of smaller, community-scale plants. This paper describes research to design, deploy and test such a sy [...]

by Jeamichel Puente Torres  , Harold Crespo Sariol  , Thayset Mariño Peacok  , Ángel Brito Sauvanell  , Greet Cuyvers  , Guy Reggers  , Pieter Samyn  , Dries Vandamme  , Jan Yperman  , Peter Adriaensens  and Robert Carleer

Received: 25 October 2022;  Published: 21 April 2023;  doi: 10.21926/aeer.2302028

The chemical regeneration of exhausted granular activated carbon (GAC) from a water treatment plant to produce dialysis water used in hemodialysis treatments for chronic renal disease patients from a general Hospital of Ciego de Avila province, Cuba, was investigated. Activated carbon (AC) exhausted mainly by inorganics (Ca (Ca-chelates), Mg and Na) was regenerated using hydrochloric acid and acetic acid (one regeneration cycle). Solutions of 5%, 10%, 15% and 20%(v/v) as well as four contact times (2 h, 4 h, 6 h an [...]

by Marina Maier  , Amela Ajanovic  and Reinhard Haas

Received: 23 June 2024;  Published: 06 December 2024;  doi: 10.21926/aeer.2404026

The transport sector accounts for approximately 25% of CO2-emissions in the EU and Austria, primarily due to passenger car transport powered by fossil fuels. Replacing conventional cars with sustainable alternatives is crucial for reducing emissions, improving air quality, and mitigating climate change while decreasing vehicle kilometers driven. This study analyzes policy strategies for Austria’s road passenger transport sector up to 2050 to determine their potential for significant CO2 reduction. Four scenar [...]

by Gemechu Fanta Garuma

Received: 29 March 2022;  Published: 06 June 2022;  doi: 10.21926/aeer.2202022

An increase in global temperature will likely result in more intense and frequent heatwaves that would last longer. Simultaneously, the growth of urban population requires more areas of land incorporated into urbanization, because most people are expected to live in cities, which will increase the intensity and duration of urban heat islands. However, the extent of the link between global warming induced heatwaves and urbanization caused heat islands is barely understood. Understanding the link would give a new inf [...]

by Elaine Beaumont  , Chris Irons  and Sue McAndrew

Received: 25 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.icm.2203045

Self-guided, smartphone apps may be helpful in reducing symptoms associated with psychological distress and may boost wellbeing, and levels of compassion. To our knowledge this is the first study to examine the impact a 28-day app based on Compassion Focused Therapy and Compassionate Mind Training has on participant’s levels of compassion, wellbeing, and self-criticism. The Self-Compassion App includes exercises, meditations, quotes, a daily wisdom, and audios, all of which aim to help individuals develop com [...]

by Walter Hughes

Received: 12 September 2018;  Published: 06 December 2018;  doi: 10.21926/obm.genet.1804052

My experiences with the identification and development of the anti-Pneumocystis drugs trimethoprim-sulfamethoxazole, dapsone and atovaquone are recounted. Attention is drawn to certain often-overlooked aspects of these drugs, including their concomitant effects against infections other than Pneumocystis, matters of dosing and adverse effects. During the past four decades several million people worldwide received chemoprophylaxis and treatment with these drugs for Pneumocystis jirovecii pneumonia. The population of [...]

by Yoko Moriyama  , Timothy Bolt  , Marilyn Luptak  and Nanako Tamiya

Received: 19 February 2019;  Published: 09 July 2019;  doi: 10.21926/obm.geriatr.1903061

Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on short notice and in emergencies. Methods: This study used city government survey results on service user satisfaction with the Japanese Long-Term Care Insurance (LTCI) system for a mid-sized, Japanese city. From this a range [...]

by Chunhui Xie  , Lillian Ye  , Yeh-Chuin Poh  and George Harb

Received: 06 May 2019;  Published: 17 July 2019;  doi: 10.21926/obm.transplant.1903072

Single cell genomics is a powerful tool to study cellular heterogeneity and discover novel cell types. Recent studies used single cell RNA sequencing (scRNA-seq) to analyze the transcriptomes of individual pancreatic islet cells. Islets are a complex mixture of endocrine cells and therefore represent an ideal tissue type for single cell transcriptomic analysis. Adult human islets consist of five known endocrine cell types (α, β, δ, γ, ε) and multiple less well-defined non-endocrine cells. In this review, we discuss [...]

by Ashrit Multani  and Stanley Deresinski

Received: 31 October 2018;  Published: 27 December 2018;  doi: 10.21926/obm.transplant.1804035

Strongyloides stercoralis, an intestinal parasitic nematode (roundworm), infects more than 100 million people worldwide. While most infected immunocompetent persons are either asymptomatic or experience only mild, intermittent symptoms, immunosuppressed individuals, including those undergoing solid organ transplantation, are at increased risk for developing the frequently fatal hyperinfection syndrome. Donor-derived strongyloidiasis has recently become increasingly recognized and reported but current donor screenin [...]

by Vincenza Frisardi  , Sara Faroni  , Angela Bellani  , Felice Biagi  , Emanuela Galante  , Alida Balzanelli  , Erika Talassi  , Lorella Frittoli  , Giancarla Capiluppi  , Claudia D'angelis  , Antonella Taragnani  , Donatella Terzi  , Elena Podavini  , Graziana Gazzoni  , Graziana Simoncelli  , Carmine Matarazzo  , Mirko Avesani  , Antonio Ventura  , Consuelo Basili  , Maurizio Galavotti  , Carlo Maria Stucchi  , Maria Cristina Cilia  and Alfonso ciccone

Received: 31 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901036

The WHO global action plan on the public health response to dementia 2017-2025 stressed the need to have a comprehensive approach with deep interconnections and cross-cutting elements through several action areas. As the elderly population grows worldwide, the number of patients with dementia increases rapidly because age is an important risk factor for developing late-onset dementia. Currently, dementia syndrome represents a true emergency. Once a diagnosis of dementia was made, informal caregivers, patients and t [...]

by Suman Mishra  , Kerry Bentley-Hewitt  , Alex Lubransky  , Bernard Venn  , Duncan Hedderley  , Hannah Dinnan  , Sheridan Martell  , Jillian Haszard  and John Monro

Received: 22 December 2021;  Published: 25 February 2022;  doi: 10.21926/rpn.2201006

People with pre-diabetes may be reluctant to add fruit to their diets due to concerns around sugars. Our objective was to measure outcomes associated with potential adverse effects of ingesting fruit sugars while assessing metabolic benefits from eating nutrient-rich kiwifruit. Thirty-four people with pre-diabetes were randomized to receive two kiwifruit or 250 mL bottled water per day for 12-weeks; two people withdrew. The primary outcomes were between-group differences for glycated haemoglobin (HbA1c) and plasma [...]

by Carsten Unglaub  and Andreas Jess

Received: 27 June 2023;  Published: 12 September 2023;  doi: 10.21926/cr.2303022

Accumulation of wax inside the catalyst pores during transient cobalt-catalyzed Fischer-Tropsch synthesis (FTS) leads to unfavorable product distribution and low activity by imposing internal mass transfer limitations. The condensation of paraffin severely changes the apparent product stream that actually leaves the reactor before the catalyst pores are filled completely and the steady state is reached. Thus, the product distribution of the transient FTS is less complex than expected in comparison to the steady-sta [...]

by Edwin Meresh  , David Daniels  , Jack H. Owens  , David Thompson  , Sarah Mennella  , Michael Levy  and Brenda Swartz

Received: 10 November 2019;  Published: 10 January 2020;  doi: 10.21926/obm.neurobiol.2001048

Agitation is a common manifestation of acute brain injury. When not addressed, agitation can lead to slower recovery rates, including delayed admission to acute rehabilitation programs. Antipsychotics are commonly used to control agitation in acute brain injury in the ICU. However, there is no current consensus on the most "efficacious and safest strategy" for use of antipsychotics in acute TBI. Haloperidol is arguably the commonly used antipsychotic for agitation in ICU setting at present. Interestingly, there are [...]

by Timothy Rossow  , Elysa J Marco  , Molly Gerdes  and Teresa Tavassoli

Received: 28 July 2021;  Published: 25 October 2021;  doi: 10.21926/obm.neurobiol.2104110

Children with neurodevelopmental conditions (NDC) often have sensory reactivity differences, such as being overwhelmed by sounds, which can elicit distress in their everyday life. Furthermore, children with an NDC often present with a greater frequency of mental health symptoms compared to their typically developing peers. However little research has examined the relationship of these sensory reactivity differences on broader mental health. This study set out to explore the relationship between sensory reactivity a [...]

by Linda J. Larson-Prior  , Gohar Azhar  , David G. Davila  , Se-Ran Jun  , Aaron S. Kemp  , Intawat Nookaew  , Jeanne Y. Wei  and Trudy M. Wassenaar

Received: 22 February 2019;  Published: 12 April 2017;  doi: 10.21926/obm.neurobiol.1702003

(1) Background: The daily rhythms of life on earth are governed by a central clock located in the hypothalamus and entrained primarily by light. By virtue of its connections to a myriad of other clocks located both in the brain and in peripheral organs and cells, this clock provides a timing signal based on the light/dark cycle by which organismal physiology and behaviour are governed. Disturbances of these natural rhythms have multiple downstream effects, frequently resulting in dysregulations of sleep and wake cy [...]

by Joan Weiss  , Nina Tumosa  , Robert Espinoza  , Elizabeth Bragg  , Jennifer Craft Morgan  , Jason D. Flatt  , Eleanor S. McConnell  and Grace Whiting

Received: 12 November 2020;  Published: 16 March 2021;  doi: 10.21926/obm.geriatr.2101162

This policy paper presents workforce development recommendations for research, clinical care and public stakeholders as they plan future research activities to strengthen the workforce to support the healthcare and social needs of persons living with dementia and their families and caregivers. To create these recommendations, the 2020 National Research Summit on Care, Services and Supports for Persons with Dementia and Their Caregivers (2020 Summit) convened a Workforce Development Stakeholder Workgroup. The Stakeh [...]

by Shuji Takabayashi  , Takuya Aoshima  , Yukari Kobayashi  , Hisayoshi Takagi  , Eri Akasaka  and Masahiro Sato

Received: 23 September 2020;  Published: 03 December 2020;  doi: 10.21926/obm.genet.2004121

Improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) was developed for in situ genome editing of the preimplantation embryos present within the oviductal lumen of mice. This method is based on intra-oviductal instillation of genome editing components and subsequent in vivo electroporation (EP) in the entire oviduct. Therefore, i-GONAD differs from the previous methods (i.e., zygote microinjection and in vitro EP) in producing genome-edited mice, which relied on ex vivo handling of preimplantation [...]

by Pras Ramluggun  and Sanj Nathoo

Received: 07 March 2019;  Published: 13 June 2019;  doi: 10.21926/obm.icm.1902036

The evolving, dynamic and challenging healthcare landscape requires that the art and science of nursing equip preregistration nursing students with the knowledge and skills to positively respond to these changes. Central to these students’ ability to demonstrate competence in the fundamentals of nursing care are core nursing attributes to meaningfully engage and attend to patients’ in delivering compassionate care and meeting their needs. The literature identifies the process of delivering compassionate care as a h [...]

by Laxminarayan Sahoo  , Payal Murmu  , Mohan Krishna Ghanta  and LVKS Bhaskar

Received: 28 June 2025;  Published: 30 October 2025;  doi: 10.21926/obm.genet.2504314

Ebstein's anomaly (EA) is a rare form of congenital heart disease (CHD), characterized by abnormal cardiac anatomy involving a defective tricuspid valve (TV), resulting in tricuspid regurgitation (TR) and cyanosis. EA is represented in different case scenarios with varying degrees of complexity across various age groups. It usually affects 0.2-0.7 out of 10,000 live births and accounts for 0.3%-0.6% of all CHD cases. While its occurrence is mainly sporadic, evidence from multiple studies suggests that EA can be ass [...]

by Sumita Jain  , Noufa Khan  , Yena Park  , Densen Cao  and Daniel CN Chan

Received: 02 May 2022;  Published: 15 June 2023;  doi: 10.21926/rpm.2302024

Zinc pyrithione (ZPT) is used to prevent microbial degradation and deterioration of manufacturing starting materials such as plastics, polymers, and latexes. The main objective of this study was to evaluate the anti-bacterial properties of ZPT. Currently, there is insufficient data on the effect of ZPT on viability of commonly encountered bacterial pathogens. We tested the efficacy of ZPT manufactured in the form of film rolls as an anti-bacterial protective layer by using the ASTM–recommended protocol on gro [...]

by Jaclyn B. Murry  and Ying S. Zou

Received: 30 June 2022;  Published: 07 November 2022;  doi: 10.21926/obm.genet.2204168

Double aneuploidy is the co-occurrence of aneuploidy of two different chromosomes within the same individual. Genomic imbalance associated with two aneuploidies in humans is associated with early lethality, and observation in live-born humans is rare. In isolation, trisomy of chromosomes 13, 18, 21, X, and Y may be better tolerated, whereas monosomy of X is the only such type of aberration that may be compatible with life. It is hypothesized that two successive malsegregation events must occur in early development [...]

by Dmitriy Melkonian

Received: 17 July 2020;  Published: 27 January 2021;  doi: 10.21926/obm.neurobiol.2101084

The probabilistic formalism of quantum mechanics is used to quantitatively link the electroencephalogram (EEG) with the underlying microscale activity of cortical neurons. Previous approaches applied methods of classic physics to reconstruct the EEG in terms of explicit physical models of cortical neurons and the volume conductor. However, the multiplicity of cellular processes with extremely intricate mixtures of deterministic and random factors prevented the creation of consistent biophysical parameter sets. To a [...]

by Katherine Satrom  , Tate Gisslen  and Raghavendra Rao

Received: 29 May 2019;  Published: 29 August 2019;  doi: 10.21926/obm.neurobiol.1903038

Hyperglycemia soon after birth is common in extremely preterm infants. Hyperglycemia is associated with severe intraventricular hemorrhage and impaired neurodevelopmental outcome in these infants. Recent data in human infants and animal models demonstrate that hyperglycemia leads to decreased white matter content, abnormal synaptogenesis, microgliosis, and functional deficits in the absence of intraventricular hemorrhage. Data suggest that oxidative stress, inflammation, and abnormal substrate metabolism are respon [...]

by Haywantee Ramkissoon

Received: 23 February 2021;  Published: 27 April 2021;  doi: 10.21926/obm.icm.2102016

The SARS-COV-2 virus has changed people’s lives and caused significant public health issues. The lockdown implemented by several governments across the globe has raised serious concerns on mental and physical wellbeing. Doctors, nurses and other COVID-19 frontline workers being put under extreme pressure to attend to patients’ health are being impacted by high stress levels which can result in burn-out and the inability to cope with the situation. This paper draws on multi-disciplinary research including complement [...]

by Rolf R. Gerhardts

Received: 11 November 2019;  Published: 17 March 2020;  doi: 10.21926/rpm.2001007

We summarize and discuss a self-consistent screening and magneto-transport theory, developed to understand the results of scanning-force-microscope experiments on the current distribution in a two-dimensional electron system (2DES), located in a narrow Hall bar under the conditions of the integer quantum Hall effect (IQHE) and its breakdown. The theory explains why, at low temperatures, at certain intervals of the applied perpendicular magnetic field, the current density is confined to “incompressible stripes” (ISs [...]

by Nidhi Sharma  and Yvonne Efebera

Received: 26 October 2020;  Published: 25 March 2021;  doi: 10.21926/obm.transplant.2101139

Graft-versus host disease is one of the major causes of death in patients undergoing allogeneic hematopoietic stem cell transplantation. Major contributing factors to severity of graft-versus host disease include HLA mismatch, conditioning regimen intensity, age of donor and recipient, source of stem cell, and donor type. Strategies and clinical trials are ongoing to reduce the incidence of graft-versus host disease, and to improve on the survival outcome of patients with graft-versus host disease, Research efforts [...]

by Nathan S. Jiang  , Byron Newton  and Xuezhi Jiang

Received: 28 June 2021;  Published: 19 October 2021;  doi: 10.21926/obm.geriatr.2104181

Osteoporosis is one of the most common disorders around the world. Osteoporotic fracture especially hip fracture are associated with an increased mortality rate in elders. However, elders with osteoporosis or at high risk of fractures remain largely underdiagnosed and undertreated. The screening, diagnosis, and treatment of osteoporosis must be improved to maintain pace with its fast-growing prevalence. This review will cover risk factors of osteoporosis, screening and diagnosis tools, newfound advancements, curren [...]