by Agnes C. Nkele  , Imosobomeh L. Ikhioya  , Chinedu P. Chime  and Fabian I. Ezema

Received: 29 May 2023;  Published: 18 July 2023;  doi: 10.21926/jept.2303024

In recent times, renewable energy resources have been greatly researched because of the increasing concern to minimize global warming and meet energy demands. Energy storage systems have become useful tools for sustainability and meeting energy needs. Solar energy has proven in recent times to be the primary and most prevalent option due to its environmental friendliness, availability, and minimal pollution. Effective utilization of available energy resources has led to developing new alternative energy devices lik [...]

by Kathy Carter  , John Campbell  , Peyton Shoemaker  , Elisabeth Dichiara  , Neel Patel  and John Caruso

Received: 09 December 2021;  Published: 23 February 2022;  doi: 10.21926/rpn.2201005

Space flight imposes a myriad of adverse effects upon the human body. Improved in-flight nutritional strategies help mitigate those adverse effects. This review examines how space flight changes human physiology, and how improved in-flight nutritional strategies may address the unique dietary needs created by microgravity exposure. Dietary approaches and recommendations to address those needs are discussed. This review also describes food sustainability methods for long-term manned space flight, how precision nutri [...]

by Tania Re  and Giuseppe Vitiello

Received: 30 April 2020;  Published: 11 June 2020;  doi: 10.21926/obm.neurobiol.2002061

The present report discusses brain visual experiences in conditions of low degree of openness of the brain toward the environment, for example, while dreaming, during meditation, or in non-ordinary brain activity states such as under the effects of psychoactive substances, in the state of coma, or in other states of reduced sensory perception, among others. In the present report, for brevity, such states are referred to as brain-mind visual experiences, implying that such a visual activity is not one connected to t [...]

by Babkir Ali

Received: 30 May 2019;  Published: 07 August 2019;  doi: 10.21926/jept.1903002

The main objective of this paper is to study the sustainability of power generation from an abandoned oil and gas well in the province of Alberta, Canada. Economic and environmental indicators were used for the sustainability assessment. A conceptual design for a pilot plant was developed, and the main parameters were determined. An abandoned oil and gas well represents the thermal power source through circulating water into an organic Rankine cycle (ORC) unit to generate electricity. The thermal power is extracted [...]

by Glenn Baxter

Received: 22 October 2021;  Published: 15 December 2021;  doi: 10.21926/aeer.2104034

The present study used a detailed qualitative longitudinal research approach to examine the trends of water consumption, wastewater volumes, and drainage water volumes in Oslo Airport Gardermoen, which is Norway’s major hub airport, between the years 2005 and 2020. An overall upward trend was observed in the water consumption at Oslo Airport Gardermoen, which was consistent with the growth in air traffic and aircraft movements during the study period. The annual water consumption per enplaned passenger was observed [...]

by Amanda Baker

Received: 04 May 2020;  Published: 07 August 2020;  doi: 10.21926/obm.neurobiol.2003069

Psychiatry is seeking interventions that could reliably sustain weight gain and psychosomatic recovery of patients with severe anorexia nervosa (AN). Currently, patients with AN, even after receiving individually-tailored therapeutic interventions, often relapse following marginal weight restoration. Also, the evidence regarding the effectiveness of psychotropic medications in relieving and treating AN symptomology is limited. The research in the field is aiming to mitigate shortcomings associated with common pract [...]

by Daria Armani  and Antonella Petri

Received: 16 June 2023;  Published: 08 November 2023;  doi: 10.21926/cr.2304026

This paper will present some sectors in which enzymes can replace traditional catalysts in poly(butylene-succinate) industry, emphasizing the green chemistry aspects associated with these newer strategies.

by Anouk A. J. Hamers  , Sunil K. Joshi  and Asha B. Pillai

Received: 29 September 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901044

The success of tissue transplantation from a healthy donor to a diseased individual (allo-transplantation) is regulated by the immune systems of both donor and recipient. Developing a state of specific non‐reactivity between donor and recipient, while maintaining the salutary effects of immune function in the recipient, is called “immune (transplantation) tolerance”. In the classic early post‐transplant period, minimizing bidirectional donor ←→ recipient reactivity requires the administration [...]

by Alexandra Rose  , Max Tupper  and Chris Irons

Received: 15 November 2022;  Published: 17 February 2023;  doi: 10.21926/obm.icm.2301015

An individual’s wellbeing at work is now recognised as key, particularly for those in challenging environment’s such as health and social care. Focusing on the cultivation of (mindful) compassion has been shown to be an effective way of improving mental health. This service evaluation focused on a pilot drop-in group for council and NHS staff, informed by Compassionate Mind Training. It was facilitated during the COVID-19 pandemic, between April – August 2020. The group was evaluated by recording the number and cha [...]

by Andrew Hede

Received: 27 July 2018;  Published: 23 December 2018;  doi: 10.21926/obm.icm.1804037

Background: Meditation has developed over many centuries within a diverse range of religious traditions including Middle-Eastern, Indian, and East-Asian. Of these, mindfulness meditation from the Buddhist (Indian) tradition, has been the most extensively adopted in the Western secular world primarily with applications in health and well-being as pioneered by Jon Kabat-Zinn. Review: While originally developed to treat chronic pain and stress in the U.S., mindfulness training was later coupled with cognitive-behavior [...]

by Gina Sizemore  , Brandon Lucke-Wold  , Charles Rosen  , James W. Simpkins  , Sanjay Bhatia  and Dandan Sun

Received: 12 January 2018;  Published: 31 May 2018;  doi: 10.21926/obm.neurobiol.1802009

The brain is an integrated network of multiple variables that when compromised create a diseased state. The neuropathology of temporal lobe epilepsy (TLE), stroke, and traumatic brain injury (TBI) demonstrate both similarity and complexity that reflects this integrated variability; TLE with its live human tissue resection provides opportunity for translational science to demonstrate scale equivalent experimentation between the macroscopic world of clinical disease and the microscopic world of basic science. The ext [...]

by Michael Fossel

Received: 14 January 2020;  Published: 15 January 2020;  doi: 10.21926/obm.geriatr.2001100

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by Andrea P. Cuevas-Gómez  , Izlia J. Arroyo-Maya  and Humberto Hernández-Sánchez

Received: 26 April 2021;  Published: 22 June 2021;  doi: 10.21926/rpm.2102027

Whey protein is a byproduct of cheese, casein, and Greek yogurt produced in Europe, North America, and Australasia. It is a substantial source of functional proteins and peptides for the worldwide food industry. α-Lactalbumin (α-La) is a globular protein that can be isolated from WPI (whey protein isolates) using techniques such as chromatography/gel filtration, membrane separation, etc. α-La is used in the elaboration of functional foods and is a very good source of peptides with anticancer, antimicrobial, antivir [...]

by Liana Spytska

Received: 04 December 2024;  Published: 14 March 2025;  doi: 10.21926/obm.neurobiol.2501275

The relevance of studying the cognitive and behavioral dynamics of psychopathy lies in its importance for improving diagnosis, therapeutic interventions, and reducing crime, thereby contributing to public safety. This study aimed to investigate how cognitive and behavioral mechanisms influence psychopathy. A combination of methods was employed, including the Levenson Self-Report Psychopathy Scale, semi-structured interviews, and the analysis of non-verbal reactions. The sample consisted of eight participants (four [...]

by Preeti Chhabra  and Kenneth L. Brayman

Received: 20 September 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004125

Clinical islet allotransplantation represents a minimally invasive, efficacious alternative to pancreas transplantation for restoring glycemic control and insulin independence in select patients with type 1 diabetes that is complicated by intractable impaired hypoglycemia awareness and/or severe hypoglycemic events refractory to stabilization by other means. Over the last decade, islet transplantation outcomes have steadily improved in part due to refinements in the selection of optimal donors, islet isolation tech [...]

by Hagit Daum  , Simcha Yagel  and Mordechai Shohat

Received: 11 March 2019;  Published: 15 May 2019;  doi: 10.21926/obm.genet.1902077

Background: Fetal exome sequencing is becoming a crucial modality for genetic investigation whenever fetal malformations are documented in the context of normal chromosomal microarray analysis (CMA). When ultrasound findings are non-specific, the robustness of exome sequencing may be the only way to achieve a molecular diagnosis during pregnancy. Case: We describe a case of multiple non-specific fetal findings with the eventual diagnosis of fetal Kabuki Syndrome by exome sequencing. Conclusions: This case stresses [...]

by Sravanthi Nandavaram  , Hannah Twist  , Rickey Evans  , Sravanthi Paluri  , Ana Castellanos  and Andres Pelaez

Received: 31 January 2024;  Published: 10 April 2024;  doi: 10.21926/obm.transplant.2402211

Thrombotic Microangiopathy (TMA) is a syndrome characterized by microangiopathic hemolytic anemia (MAHA) and thrombocytopenia. The presence of schistocytes on peripheral smear, a negative Coombs test, elevated lactate dehydrogenase, increased reticulocyte count and low haptoglobin are often the clues for MAHA. The microvascular process often targets vasculature in kidneys, brain, gastrointestinal system, heart, and skin. A timely diagnosis and treatment are often crucial to prevent severe end organ damage and death [...]

by Peter Leary  , Peter Malin  , Graeme Saunders  and Charles Sicking

Received: 03 December 2019;  Published: 29 July 2020;  doi: 10.21926/jept.2003012

A core feature of convective geothermal resource production is wellbore energy flow Q ~ ρC x T x V. E.g., for wellbore fluid of volume heat capacity ρC ~ 4.3MJ/m3.oC, temperature T ~ 230oC, and volumetric flow V ~ 50L/s, wellbore heat energy production is Q~ 50MWth ~ 5MWe. Wellbore fluid flow V =2πr0ϕv0ℓ for open wellbore length ℓ is given in turn by the spatially variable product crustal porosity times crustal fluid velocity v ≡ ϕv0 at the wellbore rad [...]

by Damien Bouvier  and Yves Giguère

Received: 01 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903093

Newborn screening (NBS) for inborn errors of metabolism (IEM) was introduced more than 50 years ago with the testing of phenylketonuria (PKU) using blood spots deposited on a filter paper after heel prick. NBS aims to identify early after birth inherited disorders for which clinical management and pre-symptomatic treatment will significantly decrease morbidity and mortality. While NBS for a few other disorders was implemented in some specific jurisdictions over the following decades, it is with the introduction of [...]

by Niccolo Caldararo

Received: 19 October 2021;  Published: 11 January 2022;  doi: 10.21926/obm.genet.2201145

The evolution of hominins, members of the zoological tribe Hominini, has been a much-studied topic, and the construction of phylogenetic trees has been the key method in molecular evolutionary studies. How scientists determine the phylogenetic trees are governed by the assumptions they place on the construction of similarities and differences in morphological traits, the differences in the number of base pairs in the genomes, and the number of similar gene clusters that code for traits (haplotypes) or are error seq [...]

by Julia Tourtelot  , Ann Bourgès  and Emmanuel Keita

Received: 09 March 2021;  Published: 26 July 2021;  doi: 10.21926/rpm.2103031

Currently, the largest among the earth excavation sites in Europe are located in the Paris region. The soils excavated from these sites are often considered waste and are not valorized. With an increasing focus on sustainable development, the demand for low-carbon building materials is rising. Although construction using raw earth is a vernacular technique, the diversity in the behavior of the raw earth building materials warrants better control of their mechanical properties. The construction techniques differ dep [...]

by Kory Floyd  , Nathan Woo  , Benjamin Custer  , Dana Dinsmore  , Kaylin Duncan  and Jeannette Maré

Received: 07 January 2022;  Published: 19 April 2022;  doi: 10.21926/obm.neurobiol.2202119

Loneliness is a common condition that poses substantial risks to morbidity and mortality. Cacioppo and Cacioppo’s [1] evolutionary theory of loneliness (ETL) provides that loneliness serves a social signaling function and also manifests in hypervigilance to threat, which we propose can influence person perception. In this experiment, 480 observers evaluated videotaped self-presentation messages from speakers who scored either high or low on a measure of loneliness. On the basis of ETL, we hypothesized that observer [...]

by Ghazaleh Ramezani  , Theo G. M. van de Ven  and Ion Stiharu

Received: 20 September 2024;  Published: 21 January 2025;  doi: 10.21926/rpm.2501004

This study investigates the hypothesis that diverse synthesis techniques can yield cellulose-graphene hybrids with tailored properties for specific applications, enabling advancements in flexible electronics, energy storage, environmental remediation, and biomedical devices. We examined and compared multiple synthesis methods, including chemical reduction, in-situ synthesis, green synthesis using natural reducing agents, solvent-assisted approaches, hydrothermal and solvothermal techniques, mechanical and chemical [...]

by Ilir Deva  and Renata van der Weijden

Received: 15 October 2021;  Published: 23 December 2021;  doi: 10.21926/aeer.2104037

Due to climate change, flood-related disasters are expected to increase. Floods generate enormous amounts of waste, including electronic waste (e-waste). E-waste should be recovered not only because it can have detrimental effects on human health and the environment but also because of the valuable metals contained in it. In this study, a system dynamics model based on current practices and waste management was established using Vensim to determine the revenue that can be generated by e-waste recycling after floods [...]

by Cristina Bagacean  , Anne Bordron  , Tempescul Adrian  , Jean Christophe Ianotto  , Gaelle Guillerm  , Wesley H Brooks  , Marie-Anne Couturier  , Mihnea Zdrenghea  , Christian Berthou  and Yves Renaudineau

Received: 05 June 2018;  Published: 14 December 2018;  doi: 10.21926/obm.genet.1804054

Epigenetic dysregulation is present in both myeloid and lymphoid disorders, with important differences reported between myelodysplastic syndromes (MDS)/acute myeloid leukemia (AML), on one hand, and chronic lymphocytic leukemia (CLL), on the other. Qualitative differences are reported in MDS/AML with gene fusions (e.g. TET1/LCX) and somatic mutations in epigenetic regulators (e.g. DNMT3A, TET2, IDH1/2), while differences in CLL are predominantly quantitative (e.g. DNMT3A, TET2). Indeed, and as supported by studies [...]

by Ibikunle Olalekan OGUNDARI

Received: 08 September 2022;  Published: 03 April 2023;  doi: 10.21926/jept.2302013

This study examined the techno-economic specifications for a Waste-to-Suburban Cooking Energy critical infrastructure project in Southwestern Nigeria. Technological and project economic data for the W2E project were obtained from strategic sources and energy project foresight/analysis framework used. The results showed residential upgraded biogas-for-cooking demand of approximately 10,243 m3/month, and municipal solid waste (MSW) input of approximately 80 tonnes/month. The planned biogas plant had estimated costs o [...]

by Amy Spallone  , Udit Dhal  , Laila Woc-Colburn  and Marion Hemmersbach-Miller

Received: 21 October 2019;  Published: 28 February 2020;  doi: 10.21926/obm.transplant.2001103

We report two cases of histoplasmosis in orthotopic liver transplant (OLT) recipients to illustrate the variable presentations, complications encountered during treatment, the spectrum of diagnostic modalities, and case outcomes. Case 1 describes the insidious presentation of presumed gastrointestinal histoplasmosis 12 years after OLT, which was defined by months of intermittent diarrhea and focal colonic disease on colonoscopy. A diagnosis of Histoplasma capsulatum was ultimately made by broad range PCR performed [...]

by Phil Ayers  , Megan Harlow  and LeAnn Scott

Received: 30 December 2021;  Published: 15 February 2022;  doi: 10.21926/rpn.2201002

Parenteral nutrition (PN) is a complex medication administered to adult, pediatric, and neonatal patients. PN is recognized as a high-alert medication by the Institute for Safe Medication Practices (ISMP). The American Society for Parenteral and Enteral Nutrition (ASPEN) has published several key recommendations regarding safe use of PN. This manuscript will review several of the important PN papers published in 2020-2021 by ASPEN.

by Jeffery Jonathan Joshua (ישוע) Davis  , Florian Schübeler  and Robert Kozma

Received: 26 November 2018;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901015

Background: Psychophysiological coherence has been widely studied as a bodily state associated with general well-being and cognitive clarity. Heart Rate Variability (HRV) has been shown to be a good biomarker to assess psychophysiological coherence. This paper presents the first general set of results concerning a study that is part of a team effort between a body of researchers in 5 countries led by the HeartMath Institute under the name, International Heart Rate Variability Synchronization (IHRVS) Study. This stu [...]

by Christine Pham  , Brett J Pierce  , Simon W Yau  , Jihad Georges Youssef  , Ahmad Goodarzi  and Howard J Huang

Received: 09 July 2021;  Published: 30 August 2021;  doi: 10.21926/obm.transplant.2103152

Data supporting the use of belatacept in non-abdominal organs are limited to case series and small cohorts involving patients requiring conversion due to CNI intolerance or contraindication. Review articles summarizing the efficacy of belatacept salvage therapy in lung transplantation have previously been published, however, dosing regimens are highly variable and uniform guidance is lacking. In this article, indications and considerations for belatacept use in lung transplant recipients are reviewed with a specifi [...]

by Roland Bardy  , Helen Akolgo-Azupogo  and Arthur Rubens

Received: 29 April 2022;  Published: 26 September 2022;  doi: 10.21926/aeer.2203036

Regulating land use and the biodiversity of a region requires lasting accords between those who make the decisions and those who are affected by the rules and regulations. In Africa, these accords depend on the effectiveness of the collective efforts of the representatives of the legal authorities and the civil society (the traditional leaders in the tribal system). In this study, we investigated the role of tribal leaders in conserving biodiversity (which is a base for obtaining accords with statutory regulations) [...]

by Alejandro Ochoa-Ramirez  , Evelyn M. Kuhn  , Jitsupa Sirinit  and Theresa A. Mikhailov

Received: 11 October 2021;  Published: 26 January 2022;  doi: 10.21926/obm.icm.2201003

Many clinical, biochemical, and anthropometric factors have been used to determine the nutritional status of critically ill children. One of the most commonly used anthropometric measurements in children is the head circumference. It is used to assess their development, and in some instances, can be an indicator of chronic malnutrition. We aim to study the association between head circumference and the nutritional status of critically ill children under 2 years old. We retrospectively obtained the head circumferenc [...]

by Lucy Watts  , Joanna Smith  , Wilfred McSherry  , Michael Tatterton  and Alison Rodriguez

Received: 04 November 2019;  Published: 03 March 2020;  doi: 10.21926/obm.icm.2001012

In palliative and end of life care settings supporting people to make sense of their lives is as important as managing disease symptoms. Dignity Therapy is a validated psychotherapeutic intervention designed to bring about a sense of meaning and purpose for individuals at the end of life. Dignity Therapy has primarily been implemented and evaluated in adult palliative care settings. Prior to designing studies that evaluate Dignity Therapy for children and young people with life-limiting and life-threatening conditi [...]

by Jean-Lionel BAGOT

Received: 22 April 2022;  Published: 11 July 2022;  doi: 10.21926/obm.icm.2203026

The application of targeted therapies (TT) in oncology has prolonged survivals and even enabled complete remission of cancers previously considered incurable. With small therapeutic indices, the reduction in dosage or spacing out of the doses of TT due to side effects, represents a significant loss of treatment opportunity for the patients. In the absence of drug interaction and significant side effects, homeopathy used in supportive care improves the quality of life of patients, compliance with oncological treatme [...]

by Changiz Mohiyeddini  , Elizabeth Carlson  , Deena Sukhon  , Wesam Almarsi  , Marwa Saad  , Daniel Eshun  and Stephanie Baker

Received: 27 May 2024;  Published: 22 October 2024;  doi: 10.21926/obm.icm.2404062

Moral injury refers to a complex psychological condition that is assumed to emerge following exposure to distressing events that challenge the moral values or ethical beliefs of individuals by direct commission, omission, observation, or betrayal by a trusted leader. Moral injury can be found across various occupational domains, such as military, healthcare, and law enforcement. Symptoms of moral injury can include guilt, a sense of moral disorientation, struggle with spiritual or existential issues, and more. This [...]

by Janusz Włodarczyk  and Alicja Włodarczyk

Received: 26 October 2020;  Published: 18 August 2021;  doi: 10.21926/obm.geriatr.2103179

Zenker’s diverticulum is a cause of benign dysphagia. The main symptoms include dysphagia and regurgitation and require diagnostics to exclude neoplastic disease. Surgical treatment is recommended for symptomatic patients. The methods of treatment include endoscopic and open transcervical techniques. Thirty-eight patients treated using the open technique between 2000 and 2020 were analyzed. Patients were qualified for the procedure after a complete diagnosis that excluded the neoplastic process. All patients were a [...]

by Catriona J Cunningham  , Marc Vives Enrich  , Molly M Pickford  , William MacIntosh-Smith  and Wenlong Huang

Received: 26 October 2020;  Published: 14 December 2020;  doi: 10.21926/obm.neurobiol.2004080

There is currently no effective treatment for spinal cord injury leaving around 90% of patients with permanent disabilities. Stem cell therapies are showing promise in preclinical studies of central nervous system injury and there is increasing evidence suggesting the improvements in functional recovery are mediated by paracrine actions. In this systematic review and meta-analysis, we aimed to determine the overall efficacy of stem cell secretome therapies in promoting recovery in preclinical models of spinal cord [...]

by Parisa Gazerani  and Brian E Cairns

Received: 26 October 2020;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101082

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. DBS has also been investigated for the treatment of cluster and other primary headaches. Electrodes are surgically implanted into brain structures, for example the posterior hypothalamus in case of cluster headache. Hypot [...]

by Elisa Martinelli  , Angelo Di Stefano  , Pietro Gareri  , Pasqualina Sapone  , Rosaria Carlucci  , Massimo Brandino  , Ettore Maina  , Sara Piscioneri  , Giada Cagnoli  and Antonino Maria Cotroneo

Received: 05 March 2023;  Published: 19 September 2023;  doi: 10.21926/obm.geriatr.2303250

As the older population increases, there is an increase in age-related chronic diseases, especially heart failure. It affects 25% of over 75-year-old outpatients and represents the leading cause of hospitalization and death in older people. This review aimed to point out the main characteristics concerning heart failure in older people, taking into account clinical symptoms, diagnosis, and treatment. An extensive search on heart failure was made on PubMed and Google, using the keywords older people, heart failure, [...]

by Shanthi Mendis

Received: 28 January 2024;  Published: 16 August 2024;  doi: 10.21926/rpn.2403011

Promoting a healthy diet is an effective strategy for preventing cardiovascular disease (CVD). The characteristics of a healthy diet are known. However, an unhealthy diet has become a significant contributor to the global burden of diseases, mainly due to its effect on CVD, diabetes, and cancer. A healthy diet is not accessible and affordable to most people worldwide. Marketing influences food choices and promotes unhealthy diets that contribute to obesity, CVD, diabetes mellitus, and cancer. Governments are respon [...]

by Abbas Ishaq  and Gabriele Saretzki

Received: 13 April 2022;  Published: 05 July 2022;  doi: 10.21926/rpn.2203016

Accumulating evidence demonstrates that senescence and the associated inflammatory phenotype (SASP) also occur in post-mitotic cells such as mature adipocytes. Visceral adipose tissue in humans is susceptible to inflammation due to nutritional imbalance and ageing. However, while adipose tissue has been well researched in the context of obesity, senescence of differentiated adipocytes has not been investigated thoroughly. Our group recently demonstrated that ageing and normal ad libitum (AL) nutrition in mice resul [...]

by Masahiro Sato  , Hansol Jin  , Eri Akasaka  and Kazuchika Miyoshi

Received: 01 September 2020;  Published: 18 February 2021;  doi: 10.21926/obm.genet.2101123

The production of genetically modified (GM) pigs is considered valuable in biomedical research for the development of model animals for various diseases and pigs with resistance against viral infection. The porcine genome may be modified using several methods, such as somatic cell nuclear transfer (SCNT) using GM cells as the SCNT donor, direct injection of the transgene or the genome editing components (GEC) into fertilized eggs referred to as zygotes, the in vitro electroporation (EP) of the zygotes in the presen [...]

by Koji Naruishi

Received: 06 September 2018;  Published: 26 October 2018;  doi: 10.21926/obm.geriatr.1804016

In Japan, the amount of aged hospitalized patients has been steadily increasing. Elderly people are susceptible to poor health, and the rise of elderly patients increases medical care expenses, which can cause economic strain. Therefore, it is clinically and socially important to reduce the occurrence of geriatric diseases, such as aspiration pneumonia and cognitive impairment. The daily care by family members is considered to be effective for the prevention of geriatric diseases, however, early detection of the di [...]

by Melita Vidakovic  , Jessica Marinello  , Maija Lahtela-Kakkonen  , Daumantas Matulis  , Vaida Linkuvienė  , Benoît Y. Michel  , Ruta Navakauskiene  , Michael S. Christodoulou  , Danielle Passarella  , Saulius Klimasauskas  , Christophe Blanquart  , Muriel Cuendet  , Judit Ovadi  , Stéphane Poulain  , Fabien Fontaine-Vive  , Alain Burger  and Nadine Martinet

Received: 30 May 2018;  Published: 16 August 2018;  doi: 10.21926/obm.genet.1803029

Background: With their varied pharmacophores, natural products are interesting tools to open the drug discovery pipeline. Several plant secondary metabolites are components of the human diet and have reported epigenetic activities. In this study, we screened a small natural compound library for epigenetic activities. Methods: Seventy-one different natural products plus 17 controls collected from all collaborating laboratories were screened. Localized DNA methylation (DNAm) was studied on a stretch of the retinoic a [...]

by Ladislav Volicer

Received: 04 November 2018;  Published: 08 November 2018;  doi: 10.21926/obm.geriatr.1804019

Behavioral symptoms of dementia

by Lindy A. Kilik

Received: 30 July 2019;  Published: 29 September 2019;  doi: 10.21926/obm.geriatr.1903076

The current paper introduces the “Priming/Timing/Miming” Model of Behavioural Care Planning for persons with Dementia. This simple heuristic provides a quick, easy and systematic way to select from the vast number of behavioural strategies offered in the BPSD literature and to organize these in a way that can be incorporated into an individualized Behaviour Care Plan to deliver personal care to persons with dementia and also to develop a larger plan of care. An entire care plan is captured on one double-sided sheet [...]

by Tyrone Pretorius  and Anita Padmanabhanunni

Received: 01 May 2022;  Published: 17 August 2022;  doi: 10.21926/obm.neurobiol.2203132

An important mental health concern arising from the COVID-19 pandemic was the loneliness resulting from the lockdown measures taken by many countries due to the outbreak. Thus, loneliness needs to be studied in detail for intervention purposes. The UCLA Loneliness Scale is the most widely used measure of loneliness. However, the 20-item measure has some drawbacks, including questionnaire fatigue, especially when used with other measures, and a lack of accurate responses to all items. In this study, we evaluated two [...]

by Mikhail Batanov-Gaukhman

Received: 10 November 2023;  Published: 26 June 2024;  doi: 10.21926/rpm.2402014

The article aims to develop the stochastic interpretation of quantum mechanics by E. Nelson based on balancing the intra-systemic contradiction (i.e., antisymmetry) between “order” and “chaos”. For the set task, it is proposed to combine two mutually opposite system-forming principles: “the principle of least action” and “the principle of maximum entropy” into one, the “principle of averaged efficiency extremum”. In a detailed consideration of the averaged states of a chaotically wandering particle, the time-indepe [...]

by Hayden Cartmill  , Paul Dargusch  and Genia Hill

Received: 10 January 2022;  Published: 06 May 2022;  doi: 10.21926/aeer.2202019

One of the biggest challenges currently presented to organisations worldwide is their ability to identify and sustainably manage greenhouse gas emissions. ‘Carbon management’, as it is referred to, is the process of understanding how and where an organisation’s activities generate emissions, and extends beyond meeting regulation requirements to being strategically utilised within businesses for social licensing, financial planning and corporate decision-making. The aim of this research is to analy [...]

by Kianoush Hatami Dehnou  and Mohammad Jafar Hadianfard

Received: 14 December 2023;  Published: 03 May 2024;  doi: 10.21926/rpm.2402011

The use of silicone rubber as an implant is limited due to its weak properties. In this study, the impact of various reinforcements, such as TiO2 or SiO2 nanoparticles, carbon, or polypropylene fiber micro reinforcements, on the mechanical, thermal, and viscoelastic properties of silicone rubber composites with RTV-4125 matrix was investigated. The composites were evaluated through several tests, including tensile, compression, FTIR, TGA, DMTA, and water adsorption tests. It was found that the composites' tensi [...]