by Yan Yang  , Gerhard Litscher  , Zemin Sheng  and Lu Wang

Received: 12 February 2020;  Published: 20 March 2020;  doi: 10.21926/obm.icm.2001015

Pain could be directly related to autonomous imbalance. To date, only one scientific work examining heart rate variability (HRV) and heart rate (HR) as the important parameters of autonomous nervous system (ANS) in the context of clinical routine acupuncture treatments for lumbosacral pain conditions is available in the listed databases. The present study aimed to investigate the short-term effects of HRV and HR, during and after the acupuncture needle stimulation in patients with lower back pain. Eighteen patients [...]

by Mohsen Akbaribazm  , Elnaz Khordad  and Mohsen Rahimi

Received: 27 September 2023;  Published: 06 March 2024;  doi: 10.21926/obm.genet.2401221

Various factors contributing to male infertility include genetic determinants, hormonal/neurological imbalance, erectile/libido disorders, genital tract injuries, and toxic/ischemic testicular injuries. Herbs increase sperm count and quality parameters, as well as sexual performance in infertile men, through various mechanisms. For this purpose, efforts were made to investigate effective plants in treating infertility, focusing on those studied in animal research. In this review, we explored the latest findings fro [...]

by Ethan G. Lester  , Amy R. Murrell  and Dickson E. Dickson

Received: 19 June 2018;  Published: 14 October 2018;  doi: 10.21926/obm.icm.1804026

Background: Mindfulness meditation (MM) is an increasing area of interest for health professionals and the general public alike. Beneficial outcomes are associated with this practice; however, definitions of mindfulness and meditation are varied, and anecdotal accounts suggest that people hold conceptions about the constructs. Furthermore, mindfulness has been incorporated into therapeutic modalities without much consideration for context, including the client’s previous experiences with and understanding of MM. To [...]

by Phillip Aouad  , Nerissa Soh  and Kristin Stedal

Received: 05 May 2020;  Published: 18 August 2020;  doi: 10.21926/obm.neurobiol.2003070

Consensus for where along the eating disorder spectrum the pathological eating behaviour of Chew and Spit (CHSP) falls has been a point of contention in academic literature. Using the case of Mary1, a 30 year old female from Australia who has engaged in excessive restrictive behaviour, was diagnosed with anorexia nervosa (AN) and has been engaging in Chew and Spit (CHSP) behaviour for over 10 years, the current paper examines the similarities from a neurobiological perspective between restrictive behaviours (akin w [...]

by Rita Payan-Carreira

Received: 30 December 2018;  Published: 29 April 2019;  doi: 10.21926/obm.genet.1902074

In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the g [...]

by Xinying Hong  and Miao He

Received: 04 May 2022;  Published: 02 August 2022;  doi: 10.21926/obm.genet.2203161

Galactosemia is a group of hereditary disorders of galactose metabolism. Newborn screening for galactosemia type I is mandatory in all states in the US since timely intervention can prevent life-threatening sequela. The biochemical basis, clinical presentation, and potential treatment options for different types of galactosemia are described. This review has a focus on the screening methodologies, including the principle of the assay, the transition from the initial bacteria inhibition test to the modern fluorometr [...]

by Max F. Platzer  and Nesrin Sarigul-Klijn

Received: 28 January 2020;  Published: 29 April 2020;  doi: 10.21926/jept.2002005

The current status of a project is described which aims to demonstrate the technical and economic feasibility of converting the vast wind energy available over the globe’s oceans and lakes into storable energy. To this end, autonomous high-performance sailing ships are equipped with hydrokinetic turbines whose output is stored either in electric batteries or is fed into electrolysers to produce hydrogen which then is compressed and stored in tanks. In the present paper, the previous analytical studies which showed [...]

by Siavash Jafari  , Mariko Vaughan  , Souzan Baharlou  , Pooria Ghadiri  , Nazila Hassanabadi  and Ashkan Nasr

Received: 11 August 2019;  Published: 09 September 2019;  doi: 10.21926/obm.neurobiol.1903039

Objectives: The purpose of this systematic literature review is to investigate the impact of case management on the link between HIV/AIDS patients (HIV-infected persons) and HIV treatment, and to investigate the impact of case management on their morbidity and mortality. Methods: We searched PubMed, Current Contents, Scopus, EMBASE, MEDLINE, the Effect Review Summary Database and the ACP Journal Club until May 2018. A randomized clinical trial examined the impact of case management on the association of PLHA with c [...]

by Anita Verma  and Anil Dhawan

Received: 14 February 2020;  Published: 11 May 2020;  doi: 10.21926/obm.transplant.2002108

The infectious complications before and after liver transplant (LT) are affected by the severity of liver disease and immunosuppression intensity after transplantation. Both cirrhosis and immunosuppression contribute to dysfunction of defensive mechanisms of the host. When a patient is evaluated for transplantation, the opportunity arises to assess the individual’s risk for infection and how one may modify those risks through prophylactic and therapeutic strategies. Pretransplant infectious disease evaluation focus [...]

by Mohammad Jafari  and Zahra Malekjamshidi

Received: 13 June 2020;  Published: 05 August 2020;  doi: 10.21926/jept.2003014

In this paper, a topology of a residential hybrid renewable energy system based on a high-frequency multi-winding transformer is introduced and analyzed. The system includes a PV and a wind-turbine as renewable energy sources, a battery as energy storage and their energies are integrated through a high-frequency transformer. In fact, the transformer integrates the energies in a magnetic form and also isolates the system inputs and outputs. The integrated output from renewables and battery is a DC high-voltage and i [...]

by Tyrone Pretorius  and Anita Padmanabhanunni

Received: 01 May 2022;  Published: 17 August 2022;  doi: 10.21926/obm.neurobiol.2203132

An important mental health concern arising from the COVID-19 pandemic was the loneliness resulting from the lockdown measures taken by many countries due to the outbreak. Thus, loneliness needs to be studied in detail for intervention purposes. The UCLA Loneliness Scale is the most widely used measure of loneliness. However, the 20-item measure has some drawbacks, including questionnaire fatigue, especially when used with other measures, and a lack of accurate responses to all items. In this study, we evaluated two [...]

by George William Nyakairu  , Mariam Onize Usman  and Muhammad Ntale

Received: 24 February 2023;  Published: 24 May 2023;  doi: 10.21926/aeer.2302033

Developing adsorbents with appreciable morphology will create new approaches for better phosphate adsorption performance. This study aims to investigate the design of an adsorbent by impregnating silver nanoparticles (AgNPs) onto calcium oxide-activated carbon (CaO-AC). The Ag/CaO-AC nanocomposite was used as an adsorbent to remove phosphate. Batch adsorption studies were performed to evaluate the effects of adsorbent dose, initial phosphate concentration, contact time, and pH on removing phosphate from an aqueous [...]

by Emily Reeves  , Brigitte Liebig  and Eveline Degen

Received: 14 July 2020;  Published: 20 October 2020;  doi: 10.21926/obm.icm.2004041

High-quality care is an important aim of palliative care services. However, the quality of care is a complex phenomenon and is subjectively perceived by those who are closest to the services and are often evaluated poorly. Prior research has highlighted the difficulties in evaluating the quality of care because of different perspectives, and still, only a little is understood about the perception of the quality of care in palliative care services. Investigating the perspectives of key individuals involved in pallia [...]

by Cristóbal Coronel-Rodríguez  and Alejandro Rodríguez-Martínez

Received: 07 May 2020;  Published: 17 July 2020;  doi: 10.21926/obm.neurobiol.2003066

Gluten-related disorders (GRDs) represent a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. The most common and widely recognized diseases within this spectrum are celiac disease and non-celiac gluten sensitivity. The clinical manifestations are intestinal, but extraintestinal manifestations may also appear, such as neurological or psychiatric. This work will specifically review the neurological or psychiatric manifestations that are more freq [...]

by Oyovwi Mega Obukohwo  , Oyelere Abosede Oreoluwa  , Odewale O. Comfort  and Afolabi Opeyemi Olanike

Received: 24 March 2024;  Published: 20 June 2024;  doi: 10.21926/obm.genet.2402246

Infertility affects millions globally, with 10-15% of couples experiencing unexplained cases. Despite advancements in medicine, the cause remains unknown, causing emotional distress. Recent research suggests a genetic basis for this issue. This review aims to provide a better understanding of the underlying genetic factors contributing to unexplained infertility and potentially identify genetic markers that could aid in the diagnosis and treatment of this condition. A literature review was conducted to understand t [...]

by Em V. Adams  , Marieke Van Puymbroeck  , Heather S. Torphy  , Brian C. Helsel  , Karen A. Kemper  , Cheryl Dye  and Arlene A. Schmid

Received: 03 October 2019;  Published: 03 January 2020;  doi: 10.21926/obm.geriatr.2001097

Falls have negative consequences for older adults, but falls can be reduced through interventions that target the reduction of fall risk factors. Cognitive behavioral education programs and therapeutic yoga are two interventions that have independently been used as a means to reduce the risk of falls. The purpose of this study was to determine if adding therapeutic yoga following an education intervention improved well known fall risk factors. Potential participants were recruited through a senior center for a 12-w [...]

by Maya Kudo  , Misa Hayashi  , Peng Tian  , Danyang Liu  , Lili Wu  , Wei Li  , Zhaoyang Hong  , Yitang Zhao  , Toshiaki Nishigaki  , Masaaki Nishihara  , Kazuo Koike  , Tonghua Liu  and Ming Gao

Received: 13 April 2020;  Published: 09 July 2020;  doi: 10.21926/obm.icm.2003033

Increased body fat mass can lead to lifestyle diseases such as hypertension, diabetes, and hyperlipidemia. Metabolic syndrome is a cluster of conditions that increases the onset of multiple diseases, such as cardiovascular diseases, stroke, and type 2 diabetes, which are closely related to lipid metabolism; therefore, new prevention approaches and treatments are needed. Our study investigated the effects and mechanism of YNCRG on anti-obesity in metabolic syndrome model SHR.Cg-Leprcp/NDmcr (SHRCP) rats. Eight-week- [...]

by Yi-Chun Hsu  , Min-Ze Lu  and Chang-Ming Liaw

Received: 18 December 2020;  Published: 28 April 2021;  doi: 10.21926/jept.2102018

This paper proposes a Wind Turbine Emulator (WTE) using an Indirect Field Oriented (IFO) Induction Motor (IM). The IM drive can be controlled as a conventional prime mover in speed mode, or a wind turbine in torque-speed mode via robust observed torque control. This paper presents key issues for establishing a high-performance IFO IM drive. Further, this study develops a wind turbine load Interior Permanent-Magnet Synchronous Generator (IPMSG) followed by a three-phase Vienna Switch-Mode Rectifier (SMR). It receive [...]

by Berta Monleón López  , Valentina Della Torre  , Federico Bilotta  and Rafael Badenes

Received: 11 June 2019;  Published: 22 August 2019;  doi: 10.21926/obm.neurobiol.1903037

Purpose of review: The purpose of this review is to describe recent evidence regarding the use of Extracorporeal Membrane Oxygenation (ECMO) as rescue therapy for refractory cardiac or respiratory failure in patients with traumatic brain injury (TBI) when conventional treatments have failed. The characteristics of these patients, including the risk of bleeding and developing malignant intracranial hypertension, are generally considered as relative contraindications to ECMO treatment; however, recent evidence sugges [...]

by Evelyne El Masri  and Tat-Hean Gan

Received: 28 May 2020;  Published: 27 August 2020;  doi: 10.21926/rpm.2003020

Carbon fibre reinforced polymer (CFRP) systems as sheets or plates are commonly used to strengthen and retrofit damaged reinforced concrete beams. In general, the bond between the FRP element and concrete defines the effectiveness of the externally bonded FRP materials. In most cases, the interface bonding behaviour is usually tested via static loading conditions. In this paper, the bonding is verified under dynamic conditions. Wave propagation is modelled in delaminated CFRP strengthened reinforced concrete beam. [...]

by Alison Knoblauch  and Paul Dargusch

Received: 24 January 2022;  Published: 05 May 2022;  doi: 10.21926/aeer.2202018

The earth’s climate is warming, increasingly straining the Earth’s human and environmental systems. Organisations are increasingly committing to net zero emissions by mid-Century to set and communicate their ambition to limit global warming to the peak temperature goals of the Paris Agreement. However, for many companies, the pathway to delivering against this ambition remains unclear – and significant investment in technical, social and economic systems required before this target becomes a reality. This paper ana [...]

by Vincenza Rita Lo Vasco

Received: 01 October 2019;  Published: 18 May 2020;  doi: 10.21926/obm.neurobiol.2002058

Mechanisms leading to neuronal cell death in human pathology are far from being fully delineated. Understanding the molecules involved in neuronal death and the timing of their recruitment might help to explain the natural history of degenerative processes, including the morphological abnormalities observed in Alzheimer’s disease (AD). Moreover, it might help refine the diagnosis by defining new molecular markers as well as find effective therapies, especially for slow cognitive deficits, often associated wit [...]

by Mitsuro Chiba  , Masafumi Komatsu  , Satomi Watanabe  and Yoko Daimon

Received: 13 January 2021;  Published: 20 February 2021;  doi: 10.21926/obm.icm.2101006

The high prevalence of obesity is a global concern. However, obesity and inflammatory bowel disease have similarities in epidemiology, diet, and gut microbial dysbiosis. An omnivorous (westernized) diet replacement with a plant-based diet in inflammatory bowel disease achieved better outcomes in both the induction and quiescent phases. Educational hospitalization providing a plant-based diet was found effective in suppressing flare-up in ulcerative colitis. This case report was designed to assess whether a plant-ba [...]

by Sarah Kölling  and Annika Hof zum Berge

Received: 22 November 2019;  Published: 11 March 2020;  doi: 10.21926/obm.neurobiol.2001052

Self-reports and actigraphy are common methods of sleep monitoring. Portable polysomnography (p-PSG) may serve as a screening tool in natural environments. Common concerns with its use are that sleep and compliance might be affected. Further, dysfunctional beliefs of the subjects may contribute to sleep disturbances, which might manifest throughout sleep monitoring. This study examined the effect of monitoring sleep patterns and attitudes among healthy individuals. Sixty-eight physically active university students [...]

by Spinello Antinori  and Laura Milazzo

Received: 28 October 2018;  Published: 15 January 2019;  doi: 10.21926/obm.transplant.1901039

Solid organ transplantation (SOT) is increasingly employed worldwide to treat several diseases causing both acute and chronic organ failure. Recipients of SOT are at an increased risk to develop infections as a consequence of immunosuppressive therapy. Sometimes such infections may be acquired by the transplanted organ or by reactivation of a previously acquired latent infection. The globalization and the increase of international travel poses a risk for exposure to infections such as Chagas disease (CD), leishmani [...]

by Trevor R Norman

Received: 07 February 2021;  Published: 14 October 2021;  doi: 10.21926/obm.neurobiol.2104108

Depression in the elderly is a significant clinical problem which is likely to endure as an ongoing issue as the cohort of individuals aged over 65years continues to increase as a proportion of the total population. While there are a multiplicity of approaches to the treatment of depression, the mainstay for moderate to severe cases is pharmacotherapy. The majority of extant antidepressants have demonstrated efficacy, at least in short term (6-12weeks) clinical evaluations. There is demonstrable efficacy over and a [...]

by Sharon F. Clevenger

Received: 20 December 2020;  Published: 07 February 2021;  doi: 10.21926/obm.icm.2101004

Healthcare workers (HCWs) have been adapting to the changing needs of people worldwide in response to the COVID-19 pandemic. The purpose of this descriptive study was to evaluate how HCWs are managing dietary self-care needs during the increased stress-load of the COVID-19 pandemic and determine if nutritional changes are being made that could place them at higher risk for mental health problems. A cross-sectional epidemiological nonprobability snowball sampling design was used to expand access to participants. Occ [...]

by Diane B. Paul

Received: 29 March 2021;  Published: 14 May 2021;  doi: 10.21926/obm.genet.2102130

This article explores difficulties encountered by those with no personal experience of a chronic disease or disability in accurately evaluating the quality of life with a condition present from birth. In most countries, cost-effectiveness analysis relies on ratings of health states by members of the general population, who must try to imagine what life for those affected is like based on (usually brief) descriptions of the conditions. That task is challenging for reasons that have been well-discussed in the literat [...]

by Masahiro Sato  , Issei Saito  , Eri Akasaka  and Emi Inada

Received: 11 October 2020;  Published: 10 March 2021;  doi: 10.21926/obm.genet.2101126

Direct colony cloning of adherent mammalian cells using rings or dilution cloning has been used frequently for obtaining stable transfectants after gene delivery. As an alternative to these methods, successful isolation of the cells in a single colony is possible by placing a trypsin-immersed small paper disk onto the colony and subsequently picking up the paper with the assumption that it carries the trypsinized cells. However, the cloning success using this technique largely relies on the cell type used. In the p [...]

by Line L. Olesen

Received: 01 February 2020;  Published: 21 April 2020;  doi: 10.21926/obm.geriatr.2002115

The knowledge about digoxin, the associated cardiac and extracardiac effects, its pharmacokinetics and dynamics, indications, dosing, and side effects is important with the objective of deriving its maximum benefit without the risk of intoxication. Although the dosing of digoxin has been standardized and its usage has declined, digoxin intoxication still occurs frequently. Due to the risk of fatal complications, it has a negative prognosis. The knowledge about the etiology and symptoms of intoxication is critical f [...]

by Michael P. Cary  , Valerie A. Smith  , Megan Shepherd-Banigan  , Jennifer H. Lindquist  , Jennifer G. Chapman  , Susan N. Hastings  and Courtney H. Van Houtven

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

by Andrew Hede

Received: 27 July 2018;  Published: 23 December 2018;  doi: 10.21926/obm.icm.1804037

Background: Meditation has developed over many centuries within a diverse range of religious traditions including Middle-Eastern, Indian, and East-Asian. Of these, mindfulness meditation from the Buddhist (Indian) tradition, has been the most extensively adopted in the Western secular world primarily with applications in health and well-being as pioneered by Jon Kabat-Zinn. Review: While originally developed to treat chronic pain and stress in the U.S., mindfulness training was later coupled with cognitive-behavior [...]

by Dagan Coppock  , Caytlin Deering  , Shara Epstein  and Dong Heun Lee

Received: 23 December 2018;  Published: 01 March 2019;  doi: 10.21926/obm.transplant.1901054

Infections are a common cause of morbidity and mortality in solid organ transplantation (SOT) recipients. Procalcitonin (PCT) has garnered attention as an inflammatory marker that has been shown to be a valuable marker for early identification of systemic bacterial infection. However, interpretation of PCTs value in the different types of infections, transplanted organs, and post-operative courses can be challenging. We review the role of PCT in the management of infections in SOT recipients. First, the PCT level c [...]

by Estefanía Espina  , José M. Marbán  and Ana I. Maroto

Received: 29 May 2023;  Published: 23 October 2023;  doi: 10.21926/obm.neurobiol.2304191

Dyscalculia is a math learning disability that significantly interferes with students' academic performance and math-related aspects of their daily lives. Early diagnosis and the design of intervention programs adapted to the needs of each case are essential. In this sense, multiple technological resources are created to address both issues. Still, it is difficult to identify which characteristics they share and which are more relevant regarding didactic suitability. Given this situation, this research proposes cat [...]

by Gabrielle M Mey  and Jacob T Mey

Received: 24 August 2022;  Published: 16 November 2022;  doi: 10.21926/rpn.2204022

This narrative review highlights recent advances and ongoing trials using nutrition approaches for healthy aging. Focus will be placed on nutrition therapies that target cognition (“the mind”) and mobility (“the muscle”), both critical components to maintaining a high quality of life for older adults. For “the mind,” two seemingly incongruent therapies are being investigated to improve cognition–the MIND diet (high in carbohydrates and anti-oxidant fruits and vegetables) and the ketogenic diet (low in carbohydrates [...]

by Tina Rawal  , Jean W.M. Muris  , Vijay Kumar Mishra  , Monika Arora  , Nikhil Tandon  and Onno C.P. van Schayck

Received: 10 January 2022;  Published: 30 March 2022;  doi: 10.21926/rpn.2201010

COVID-19 greatly affected the lives of adolescents through restrictions such as less playtime, more screen time, and limited interaction with peers. In this study, we assessed the impact of the COVID-19 pandemic on the dietary and physical activity-related behavior of school students aged 10–16 years. This cross-sectional study was conducted with adolescents recruited from seven randomly selected private schools in Delhi, India, during 2021. A self-administered web-based survey was conducted to evaluate the behavio [...]

by Michael Mazzei  , Suresh Keshavamurthy  , Olga Timofeeva  and Yoshiya Toyoda

Received: 11 September 2020;  Published: 04 January 2021;  doi: 10.21926/obm.transplant.2101130

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means [...]

by Mateus Carvalho  , Ana Paula Oliveira  , Francieli Mayer  , Cesário Virgens  and Maria do Carmo Rangel

Received: 31 August 2022;  Published: 02 November 2022;  doi: 10.21926/cr.2204038

Catalytic pyrolysis is an attractive alternative for converting biomass into energy and chemicals to replace fossil sources. This has encouraged the search for efficient catalysts that can directly remove oxygenated products during pyrolysis, since they are the main problem in the processing and use of the products obtained. The catalytic and non-catalytic pyrolysis of medium density fiber (MDF) over beta zeolite-supported nickel (3 and 5%) was performed using the biomass/catalyst of 1.0/0.2 ratio. The thermokineti [...]

by Gary Stanton

Received: 22 March 2019;  Published: 04 June 2019;  doi: 10.21926/obm.icm.1902034

A 16 year old girl was evaluated for intractable hiccups for 6 six months, with a prior negative clinical and laboratory evaluation, and without any improvement with a variety of folk and medicinal therapies. A single treatment session of auriculotherapy produced a full clinical remission.

by Rama Jaiswal  , Melad Shaikh  and Kalluri V. S. Ranganath

Received: 01 June 2023;  Published: 21 November 2023;  doi: 10.21926/cr.2304028

A surface modification approach has prepared a nanostructured organic framework connecting two metal oxide NPs. The surface modifier attached two metal oxide NPs via molecular interaction to generate modular structures of fiber, rod, or sponge materials. Thus, obtained hybrid systems have been confirmed through FT-IR, TGA, PXRD, and SEM. Metal oxides such as Fe3O4 and MgO generated mixed materials via the surface modification approach. Thus, obtained materials have been successfully used to dehydrate biomass-derive [...]

by Omar Alelweet  , Sara Pavia  and Zehao Lei

Received: 28 September 2021;  Published: 29 November 2021;  doi: 10.21926/rpm.2104047

This paper investigates the composition, properties and reactivity of a red mud waste generated in Saudi Arabia with a view to find alternative materials to replace construction binders of high environmental impact. The phase transformation triggered by the sintering of the RM up to 1000°C is determined with thermal and X-Ray Diffraction analyses. Reactivity is investigated with chemical and physical methods including the Chapelle test, setting times, mechanical index and microscopy. The RM is clearly pozzol [...]

by Virginie Vignard  and Delphine Fradin

Received: 13 March 2018;  Published: 15 May 2018;  doi: 10.21926/obm.genet.1802020

Melanoma is a highly aggressive skin cancer with high incidence worldwide. There is growing evidence that aberrantly expressed non-coding RNAs (ncRNAs) play a role in the development, progression and dissemination of melanoma tumor cells. Among the many types of ncRNAs described in this review, the functions of micro- and long non-coding RNAs are described and related to the six hallmarks of cancer. Recently, ncRNAs discovered in body fluids have become known as one of the most promising groups of oncological bioma [...]

by Kwang Poo Chang  , Dennis K.P. Ng  , Chia-Kwung Fan  , Ramesh B. Batchu  and Bala K. Kolli

Received: 29 December 2019;  Published: 24 February 2020;  doi: 10.21926/obm.genet.2001103

The parasitic protozoa in the genus of Leishmania have exceptionally favorable attributes for exploitation as a vehicle for safe and effective delivery of transgenically incorporated vaccines against infectious and malignant diseases. A dual suicidal mechanism was installed in Leishmania via genetic and chemical engineering in vitro for accumulation of photosensitizers, rendering them sensitive to dim light for inactivation. Leishmania so inactivated are non-viable, but immunologically competent to deliver vaccines [...]

by Katie M. Hinsey  , Karen E. Atler  , Christine A. Fruhauf  , Ruby A. Bolster  , Marieke Van Puymbroeck  and Arlene A. Schmid

Received: 07 March 2018;  Published: 11 June 2018;  doi: 10.21926/obm.icm.1802010

Background: A fall prevention intervention was delivered to people with chronic stroke (Merged Yoga and Occupational Therapy intervention-MY-OT). All caregivers were invited to also attend the 8-week intervention and were included in these analyses. Methods: The aim of this study was to examine changes in caregiver burden, positive aspects of caring, and caregiver's experiences after participating in the MY-OT intervention. This was a secondary data analyses and the purpose of this mixed-methods study was to quanti [...]

by Mariette Kokolo  and Montse Bach-Elias

Received: 25 June 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004118

Non-coding RNAs (ncRNAs) have emerged as one of the most abundant regulatory molecules. However, their roles and functions are significantly different from those of proteins. Moreover, around 95% of the human genome contains non-coding DNA. ncRNAs contribute by far the majority of human transcriptional units, and the functions of the most are yet unknown. Here, we highlight that an important RNA sequence region, encompassing an exon-intron hairpin loop (also called IDX-rasISS1), of the H-Ras pre-mRNA may encode an [...]

by Christopher Lam

Received: 25 April 2019;  Published: 08 July 2019;  doi: 10.21926/obm.icm.1903044

Compassion and kindness can be cultivated and enhanced. Over the years in medical practice I have witnessed many healthcare workers, after having worked with kind and caring practitioners, become progressively more humane. Those of us who are teachers need to be mindful of that. In educating new physicians, compassion should play a central role and we as practicing doctors are well placed to model a caring and empathetic approach to our patients. There is also a fundamental need to look after ourselves and main [...]

by Parisa Gazerani  and Brian E Cairns

Received: 26 October 2020;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101082

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. DBS has also been investigated for the treatment of cluster and other primary headaches. Electrodes are surgically implanted into brain structures, for example the posterior hypothalamus in case of cluster headache. Hypot [...]

by Khalid Nawaz  , Iqra  , Muneeb Ullah  , Jin-Wook Yoo  , Umme Aiman  , Madiha Ghazanfar  and Muhammad Naeem

Received: 21 June 2024;  Published: 10 January 2025;  doi: 10.21926/rpn.2501002

The persistent inflammation of the intestinal mucosa is the main characteristic of inflammatory bowel disease (IBD), a lifelong illness that affects people of both genders. The exact etiology is still undefined while previously it was attributed to genetic components. Later, it was investigated that the environment has an equal effect on the development of IBD encompassing both Crohn’s disease (CD) and Ulcerative colitis (UC). Among environmental risk factors linked to IBD, diet, notably the transition toward the W [...]

by Vardan Apinyan

Received: 30 March 2023;  Published: 24 June 2023;  doi: 10.21926/rpm.2302026

This paper considers a finite-sized two-leg ladder of spin-1/2 particles with local inter-chain Ising interaction. We include the effects of an external magnetic field by incorporating a Zeeman-type coupling between the magnetic field and the spins localized on the lattice sites. To analyze the system, we utilize the transfer-matrix formalism to calculate the partition function. We compute the magnetization for different configurations by varying the system's parameters. We observe the presence 3of spontaneous magn [...]

by Gemechu Fanta Garuma

Received: 29 March 2022;  Published: 06 June 2022;  doi: 10.21926/aeer.2202022

An increase in global temperature will likely result in more intense and frequent heatwaves that would last longer. Simultaneously, the growth of urban population requires more areas of land incorporated into urbanization, because most people are expected to live in cities, which will increase the intensity and duration of urban heat islands. However, the extent of the link between global warming induced heatwaves and urbanization caused heat islands is barely understood. Understanding the link would give a new inf [...]