by Dietmar Payrhuber  , Piero Sangaletti  and Josef Muehlmann

Received: 10 May 2018;  Published: 10 June 2019;  doi: 10.21926/obm.icm.1902035

(1) Background: The article provides insight into the mode of the immune system acting hierarchically when administering potentized remedies. Occasionally, this can be best seen in severe cases as available with cancer. (2) Methods: The careful anamnesis and subsequent prescription is based on Jan Scholten’s hierarchic classification of homeopathic mineral remedies. (3) Results: In such cases we find syndrome shifts of symptoms shifting from vital to less vital organs, from inside outside and from up downwards, e [...]

by Istvan Széchenyi

Received: 16 October 2018;  Published: 26 February 2019;  doi: 10.21926/obm.icm.1901013

Background: In the international auriculotherapy practice there are relatively big differences in the exact localization of the same ear acupuncture point. On one hand, there are specialists who devote their efforts to find the active points. In that case it becomes intriguing that there may be another point (at 1-2 mm distance) near the point to be treated, indicating a relatively strong, even stronger activity than the one they were initially aiming to find. That point may be active because of another health prob [...]

by Shaikha Al-Ballam  , Hamidreza Karami  and Deepak Devegowda

Received: 27 September 2022;  Published: 14 November 2022;  doi: 10.21926/jept.2204036

Electrical Submersible Pumps (ESPs) are one of the most widely used artificial lift methods in the petroleum industry. However, ESP failures are unanticipated and common occurrences with significant financial impacts for the operators. Analysis of the ESP performance and failures are essential in its design and optimization. This paper presents a statistical approach for diagnosing and evaluating the root causes of ESP failures. The analysis is based on the field data gathered from the surface and downhole ESP moni [...]

by Yang Zhang  , Jiawen Chen  , Xiaowen Hu  , Wei Zhao  , Dirk J. Broer  and Guofu Zhou

Received: 17 August 2021;  Published: 01 November 2021;  doi: 10.21926/rpm.2104044

The reverse mode polymer dispersed liquid crystal (PDLC) is an emerging smart window technology. Unlike traditional PDLCs, a reverse mode PDLC can be transparent and opaque in the absence and presence of an external electric field. This report provides a brief introduction to several reverse modes PDLC smart window technologies, focusing on polymer-stabilized liquid crystals (PSLCs). The systems based on electrohydrodynamic instability (EHDI) of liquid crystals have also been discussed. The working principles, mode [...]

by Mohammad Harun-Ur-Rashid  and Abu Bin Imran

Received: 30 June 2024;  Published: 30 September 2024;  doi: 10.21926/rpm.2403024

Emerging Trends in Engineering Polymers signify a pivotal transformation in material engineering, marking a departure from traditional materials towards innovative, multifunctional, and sustainable polymers. This review delineates the forefront of advancements in polymer materials, including high-performance, bio-based, biodegradable, innovative, and functional polymers. Highlighting their enhanced mechanical properties, thermal stability, and chemical resistance showcases these materials' pivotal role in driving t [...]

by Sabine Neusatz Guilhen  , Tamires Watanabe  , Thalita Tieko Silva  , Suzimara Rovani  , Júlio Takehiro Marumo  , Jorge Alberto Soares Tenório  , Ondřej Mašek  and Leandro Goulart de Araujo

Received: 19 April 2022;  Published: 19 May 2022;  doi: 10.21926/rpm.2202010

The point of zero charge (PZC) is an inherent electrokinetic property of biochars (BC). It influences the adsorption process under certain pH conditions. Herein, we report the method of determination of the PZC values of ten standard BCs. We used the salt addition method to select the BCs with suitable properties for methylene blue (MB) removal from aqueous solutions. The standard BCs were obtained by pyrolyzing five different biomasses at two distinct temperatures (550°C and 700°C). The BCs derived from rice husk [...]

by Myllena R. Rodrigues dos Santos  , Daniela B. Battaglia Hirata  and Joelise A.F. de Alencar Figueira Angelotti

Received: 16 February 2022;  Published: 07 May 2022;  doi: 10.21926/cr.2202013

Enzymes are extensively used in biotechnological processes in several areas of industry. They are sustainable and safe, and their specificity is another characteristic that improves the performance in the process. Among enzymes, lipase is relevant due to the ability to play different roles in the industry and the possibility of collecting them from microbial sources that are found in industrial residues. This can reduce the costs of enzyme production. In relation to that, lipase immobilization is an interesting pro [...]

by Patricia L. Gerbarg  , Richard P. Brown  , Chris C. Streeter  , Martin Katzman  and Monica Vermani

Received: 10 April 2019;  Published: 12 July 2019;  doi: 10.21926/obm.icm.1903045

Does compassion itself benefit the healing process or does the activation of neurophysiological processes, from which the experience of compassion arises, trigger a cascade of physical and psychological changes that support health and well-being? Exploration of the neurological substrates of compassion reveals multiple healing pathways that can be activated by mind-body practices. Furthermore, these pathways affect physical health, emotion regulation, and how we perceive and relate to others. Physiological states a [...]

by Sydney Katras  , Dejian Ma  , Ayman al Dayeh  and David Tipton

Received: 31 March 2021;  Published: 12 August 2021;  doi: 10.21926/rpm.2103034

Bisphenol A (BPA) is a widely used synthetic compound that has been identified as an endocrine disruptor. It has been linked to adverse health effects such as developmental defects, infertility in both men and women, cardiovascular disease, and obesity. There has been increased interest in BPA’s effects on the developing fetus and data has revealed that doses below the presumed safe dose can produce harmful effects. Orthodontic clear aligner therapy is a popular treatment modality that involves the patient we [...]

by Mikhail Kipnis  , Elvira Volnina  , Igor Belostotsky  , Roman Galkin  , Natalya Zhilyaeva  , Ivan Levin  , Sergey Kottsov  and Alexander Ezhov

Received: 09 September 2021;  Published: 19 September 2022;  doi: 10.21926/cr.2203027

A precursor CuO/ZnO/Al2O3 catalyst for methanol synthesis has been prepared at room temperature by introducing a ternary salt solution into the excess of sodium carbonate solution following the reverse co-precipitation method. The catalyst was tested for the synthesis of methanol from synthesis gas. The composition (vol. %) has been presented: CO, 22; CO2, 5.8; N2, 5.5; H2, balance. The methanol productivity was recorded to be 2.7 kg kgcat–1 h–1 at a temperature of 260 °С, a pressure of 3 MPa, and a [...]

by David Feinstein

Received: 27 January 2022;  Published: 01 April 2022;  doi: 10.21926/obm.icm.2202015

The vague or controversial use of the term energy in the clinical subdiscipline known as "energy psychology" has been an obstacle to the field's acceptance. This paper discusses five forms of energy and explores the role of each in energy psychology treatments. While patterns in (a) electrical signaling, (b) brain waves, and (c) electromagnetic fields are presumably shifted in any form of effective psychotherapy, a strength of energy psychology interventions is shown to be in their ability to initiate such effects [...]

by Joshua C. Brown  and Jessica L. Broadway

Received: 01 December 2020;  Published: 20 April 2021;  doi: 10.21926/obm.neurobiol.2102091

Lamotrigine is generally accepted as a well-tolerated medication with few cognitive side effects. Here, we report a case of a 62-year old female with a severe, rapidly progressive dementia-like process which was completely reversed after reduction of lamotrigine. Associated findings included hyperreflexia with clonus, ataxia, Wernicke-like dysphasia, global cognitive impairment, burst suppression on electroencephalogram (EEG), and bilateral parietal hypo-metabolism on fluorodeoxyglucose-Positron Emission Tomography [...]

by Francesco E. Negro  and Francesco V. Marino

Received: 26 April 2021;  Published: 07 November 2021;  doi: 10.21926/obm.icm.2104045

The 19th century saw an explosion of serious epidemic diseases, such as smallpox and scarlet fever, which led to the development of an alternative system of medicine called homeopathy. Under this system, S. Hahnemann developed a rigorous methodology based on repeated observations on the field, leading to successful results. The aim of this work is to depict the birth and evolution of his thought. The correct understanding and application of this methodology became the reference model for subsequent generations of h [...]

by Peter Morrell

Received: 06 June 2018;  Published: 23 August 2018;  doi: 10.21926/obm.icm.1803016

This paper explores some of the conceptual issues that arise when comparing homeopathy with the mainstream medical system, both in terms of their underpinning philosophies and in their treatment methods, and especially when applied to the problem of cancer. A review is under-taken of the key concepts that underpin both medical approaches: the holistic approach of homeopathy and the reductionist approach of mainstream medicine. The article closes with a discussion of the emerging conflicts between classical homeopat [...]

by Terence Seedsman

Received: 29 January 2019;  Published: 24 May 2019;  doi: 10.21926/obm.geriatr.1902055

The history surrounding the notion of ‘informed consent’ is provided in the interest of setting a framework for the emergence of an ethics of aged care. Informed consent negligence is seen as a breach of duty involving potential litigation through the legal concept of ‘failure to warn’. Respect for the autonomy of older persons is highlighted as a cornerstone of care by medical professionals and family members. There remains the challenge, however, of caring for older people who do not have full decision-making cap [...]

by Salvador Vargas-Molina  , Jorge L. Petro  , Diego A. Bonilla  , Eneko Baz-Valle  , Leandro Carbone  , Roberto Cannataro  and Javier Benítez-Porres

Received: 25 November 2021;  Published: 09 March 2022;  doi: 10.21926/obm.icm.2201010

Cluster-set resistance training is focused on performance improvements of sports by increasing the repetition maximum, jump height, and efficiency in the sprint. In this commentary, we present relevant aspects to optimize the use of cluster training under the context of muscle hypertrophy. Therefore, we address intra-sets pauses, the number of repetitions per block, and strategies that benefit this methodology. During a cluster set resistance training program, not only the total number of repetitions could be highe [...]

by Panagiotis Kyriakopoulos  , Athanassios Giannopoulos  , Yannis G. Caouris  , Manolis Souliotis  and Mattheos Santamouris

Received: 04 September 2021;  Published: 06 December 2021;  doi: 10.21926/aeer.2104032

The hourly ambient air temperature information was analyzed for two Greek coastal Mediterranean cities: Patras (for the entire 2018 year) with ten urban and one rural stations, and Kalamata (for the entire 2019 and 2020 years) with eight urban and two rural stations. The heating and cooling Degree Hours (DH) and Degree Days (DD) were calculated, for base temperatures of 18 °C and 26 °C, respectively. The urban heating degree hours for the cities of Patras and Kalamata were observed to be 19.2% and 24%, respectively [...]

by Igor Travar  , Jean Noel Uwayezu  , Jurate Kumpiene  and Leo W.Y. Yeung

Received: 15 December 2020;  Published: 19 April 2021;  doi: 10.21926/aeer.2102006

The use of per-and poly-fluoroalkyl substances (PFAS) has resulted in the contamination of different environmental matrices. In EU countries, the sites contaminated with PFAS are usually remediated by excavating the soil and disposing of it in a landfill, as no in-situ or on-site techniques capable of treating large quantities of soil cost-effectively have been developed. Landfilling of PFAS-contaminated soil is one of the sources of PFAS in landfill leachate. In this paper, the physical and chemical treatment meth [...]

by Michael Fossel

Received: 31 December 2018;  Published: 15 February 2019;  doi: 10.21926/obm.geriatr.1901034

The consensus that cell senescence plays a role in age-related disease has prompted a number of potential clinical interventions, including attempts to reset cell senescence and attempts to remove senescent cells from aging tissues. The latter approach, senolytic therapy, has attracted considerable attention, but both theoretical considerations and published data suggest that the clinical benefits will be transient and that senolytic therapies will likely accelerate long-term degenerative disease. We review the ove [...]

by Sheri R. Levy  and MaryBeth Apriceno

Received: 20 June 2019;  Published: 28 October 2019;  doi: 10.21926/obm.geriatr.1904083

Worldwide, people are living longer but not necessarily experiencing optimal health since healthy ageing stems from a combination of biological, psychological, and social factors. The growing interdisciplinary literature on ageism from fields such as education, medicine, psychology, and social work increasingly highlights the pivotal role that ageism plays in ageing. Ageism is generally an overlooked factor in understanding and fostering healthy ageing. Ageism creates a negative view of the ageing process as marked [...]

by Binita Boro  , Shivam Porwal  , Dinesh Kumar  , Snehangshu Mishra  , Subrata Ghosh  , Sakshi Kansal  , Amreesh Chandra  and Trilok Singh

Received: 14 August 2022;  Published: 14 October 2022;  doi: 10.21926/cr.2204033

Solar cells based on organic-inorganic lead halide perovskites are popular in the photovoltaic community due to their high efficiency, low cost, and solution processability. Understanding the fundamentals of metal halide perovskite and its interfaces is extremely important for achieving high-quality materials and developing efficient devices using these materials with the necessary properties. Various methodologies have been used to evaluate the excellent optoelectronic properties, efficiency, and stability of PSCs [...]

by Alkyoni Athanasiou-Fragkouli  , Michael T Lynskey  , Anne Katrin Schlag  and David J Nutt

Received: 01 March 2024;  Published: 05 June 2024;  doi: 10.21926/obm.icm.2402032

Chronic pain is one of the most common conditions for which people seek treatment with cannabis-based medicinal products (CBMPs) and there is mounting real world evidence that CBMPs are safe and effective in treating pain. Many people with chronic pain also experience major depression and it is unknown whether pain patients with major depression derive equal benefit from CBMPs as those who are not depressed since comorbidities are usually an exclusion factor in RCTs. This study aimed to investigate whether patients [...]

by Sue Anne Fuller  and Peta Stapleton

Received: 17 June 2021;  Published: 26 October 2021;  doi: 10.21926/obm.icm.2104038

A 37-year-old female with a history of complex trauma, anxiety and depression was treated with Emotional Freedom Techniques (EFT) supplemented with guided imagery within the first 24 hours of having a stroke that affected the right side. CT scans indicated a haemorrhage and brain clot. Surgery was delayed as another seizure was expected. Interventions occurred during COVID-19 restrictions. The patient then engaged in 90 minutes of EFT every day over the course of a week while in hospital. After seven days she was d [...]

by Chingrishon Kathing  and Geeta Saini

Received: 15 October 2022;  Published: 30 December 2022;  doi: 10.21926/rpm.2204028

Wastewater generated by the textile industry has been a major environmental concern for a long. Production of fiber involves various steps and uses a lot of chemicals, dyes, and water. Therefore, the effluent produced from the textile industry needs proper purification before discharging into the water body. The current review summarizes various physical and chemical methods like ion exchange, coagulation-flocculation, membrane separation, membrane distillation, oxidation, ozonation, etc., for wastewater treatment. [...]

by Dean M. Cordingley  and Stephen M. Cornish

Received: 04 July 2022;  Published: 12 October 2022;  doi: 10.21926/rpn.2204021

Exercise induced muscle damage occurs following strenuous and unfamiliar exercise and results in biomarkers of muscle damage and inflammation in the circulation. Creatine (Cr) is a commonly utilized nutritional supplement which has been proposed to enhance post-exercise recovery and has been suggested to decrease exercise induced inflammation. Exercise is well recognized to be beneficial for older adults to maintain skeletal muscle mass and strength as well as promote health for other biological systems. However, o [...]

by Gabriele Cipriani  , Sabrina Danti  , Cecilia Carlesi  , Claudio Lucetti  , Angelo Nuti  and Mario Di Fiorino

Received: 27 March 2019;  Published: 16 August 2019;  doi: 10.21926/obm.geriatr.1903070

Background: Mania in older adults is associated with a high rate of medical and neurological disease. Objective: The goal of this review is to describe the phenomenon of manic episodes in patients suffering from dementia. Methods: Medline and Google Scholar searches were conducted for relevant articles, chapters, and books published before 2019. Search terms used included dementia, late-onset, mania, and elderly. Publications found through this indexed search were reviewed for further relevant references. Resultsan [...]

by Ernesto de Titto  and Atilio Savino

Received: 22 December 2023;  Published: 11 June 2024;  doi: 10.21926/aeer.2402014

Management of municipal solid waste (MSW) is frequently not properly performed. Whenever this happens, those working in the different stages of the process, as well as residents close to the dumps, face health risks. Here, we revised the documented evidence of emissions liberated during MSW management and associated health problems to investigate if systematic and reproducible relationships can be established. Besides substances released during collection and transportation, various toxic substances, predominantly [...]

by Karin Matko  , Holger C. Bringmann  and Peter Sedlmeier

Received: 08 March 2021;  Published: 13 September 2021;  doi: 10.21926/obm.icm.2103030

Traditional yoga encompasses a variety of practices, such as postures, breathing techniques, meditation, and ethical teachings. However, little is known about how different components of yoga contribute to its overall effect. In this meta-synthesis, we comprehensively summarized the current evidence on differential and incremental effects of various yoga components collected from available meta-analyses. For this meta-analysis, we searched Medline/PubMed, Scopus, PsychInfo, and the Cochrane Library in July 2021. We [...]

by Shih-Ang Hsu

Received: 21 December 2020;  Published: 24 March 2021;  doi: 10.21926/jept.2101014

In order to improve offshore wind power operation and maintenance (O&M), particularly during tropical and non-tropical cyclones, short-term forecasts or nowcasts up to 6 hours of meteorological and oceanographic (met-ocean) parameters including wind, waves, currents and turbulence intensity are needed. On the basis of numerous air-sea and wind-wave interaction experiments, datasets are analyzed including those from simultaneous measurements of wind and waves during Hurricane Wilma. Formulas are presented for nowcas [...]

by Eileen J. Carter  , Srijesa Khasnabish  , Jason S. Adelman  , Michael Bogaisky  , Mary Ellen Lindros  , Lois Alfieri  , Maureen Scanlan  , Ann Hurley  , Megan Duckworth  , Alexandra Shelley  , Kenrick Cato  , Shao P Yu  , Dianne L Carroll  , Emily Jackson  , Stuart Lipsitz  , David W Bates  and Patricia C. Dykes

Received: 23 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.geriatr.2002119

Falls represent a persistent and costly patient safety issue. Fall TIPS (Tailored Interventions for Patient Safety) is a patient-centered and clinical decision-supported, fall prevention program that has led to fewer falls and related injuries among hospitalized patients. We aimed to identify dominant facilitators and barriers to Fall TIPS adoption. This multisite qualitative study was conducted in 11 hospitals representing three academic health systems, where Fall TIPS had been implemented for at least one year. I [...]

by Reddy A Bharat  , Shetgaonkar Pundalik Prathmesh  , Fatma Sarsu  and Penna Suprasanna

Received: 24 December 2023;  Published: 29 April 2024;  doi: 10.21926/obm.genet.2402233

Induced mutagenesis has emerged as an essential field of plant breeding to address global food security challenges, offering tools to enhance crop productivity, resistance, and nutritional value. Among the mutation induction tools, the physical mutagen such as gamma rays holds promise for efficient mutation induction. Gamma rays, a type of high-energy electromagnetic radiation, possess unique characteristics that enable them to penetrate plant tissues and induce genetic mutations. The biological effects are influen [...]

by Argyrios V. Karatrantos  , Md Sharif Khan  , Chuanyu Yan  , Reiner Dieden  , Koki Urita  , Tomonori Ohba  and Qiong Cai

Received: 24 May 2021;  Published: 27 September 2021;  doi: 10.21926/jept.2103043

The performance of metal-ion batteries at low temperatures and their fast charge/discharge rates are determined mainly by the electrolyte (ion) transport. Accurate transport properties must be evaluated for designing and/or optimization of lithium-ion and other metal-ion batteries. In this review, we report and discuss experimental and atomistic computational studies on ion transport, in particular, ion diffusion/dynamics, transference number, and ionic conductivity. Although a large number of studies focusing on l [...]

by Lauren E. Guerriero  and Bruce F. O'Hara

Received: 12 February 2019;  Published: 24 May 2019;  doi: 10.21926/obm.icm.1902031

Meditation describes a large variety of traditions that are extremely variable, but all include the conscious focus or awareness of attention. By maintaining their attention, meditators experience both acute and long-term changes in physiology, anatomy, and cognitive performance. The literature shows that the type of performance benefits may depend on the specific type of mental training. During meditation practice there is a documented increase in neuronal coordination and slowing of neuronal firing across many re [...]

by Thomas Eggermann  , Deborah J.G. Mackay  and Zeynep Tümer

Received: 28 June 2018;  Published: 30 August 2018;  doi: 10.21926/obm.genet.1803031

Uniparental disomy (UPD), the inheritance of both homologues of a chromosome from only one parent, has been reported for nearly all human chromosomes. Depending on its mode of formation and time of occurrence, UPD can be present in all cells of an organism, or restricted to some cell lines as a mosaic UPD. Though its general frequency is unknown, it becomes clinically relevant when it produces homozygosity for recessive pathogenic variations or is associated with chromosomal imbalances. UPDs are well-known for thei [...]

by Esther Mbuci Kinyua  , George William Atwoki Nyakairu  , Emmanuel Tebandeke  and Oghenekaro Nelson Odume

Received: 19 February 2023;  Published: 20 July 2023;  doi: 10.21926/aeer.2303039

Recently, microplastics have emerged as a major environmental pollutant and have been documented globally. Several studies have shown that microplastics can accumulate heavy metals and persistent organic pollutants as they pass through the environment due to their functional groups interacting with and complex these substances. While conventional wastewater treatment methods can reduce a significant amount of microplastics, many still make their way into rivers and oceans worldwide from their effluents. One of the [...]

by Suheir Awadalla  , E Bethan Davies  and Cris Glazebrook

Received: 21 October 2024;  Published: 31 December 2024;  doi: 10.21926/obm.neurobiol.2404261

Numerous studies have explored the prevalence of depression and anxiety symptoms among university students worldwide. However, only a few have examined how these symptoms affect students' academic performance. This systematic review explores the relationship between depression, anxiety, and academic performance among undergraduate university students. Peer-reviewed articles published between 1997 and June 2020 were included if they: (a) were in English; (b) had a study population that was exclusively undergraduate [...]

by Nikita Francis

Received: 15 March 2020;  Published: 01 June 2020;  doi: 10.21926/obm.geriatr.2002121

Despite continuous efforts to combat neurodegenerative diseases, researchers have been unable to find an intervention that reverses degeneration and/or improves cognition in dementia or healthy aging. Therefore, it is considerably important to identify lifestyle factors that could potentially aid in healthy brain aging and prevent or delay neurodegenerative diseases. The emerging interest in the ancient practice of fasting has inclined researchers to study the physiological and behavioral effects of this practice. [...]

by Mykhailo Zhylin  , Viktoriia Mendelo  , Svitlana Bondarevych  , Yuliia Kokorina  and Andrii Tatianchykov

Received: 08 July 2024;  Published: 22 November 2024;  doi: 10.21926/obm.neurobiol.2404256

Emotional regulation (ER) is the process by which people change their physiology, expressions, and emotional experiences to operate in their daily lives. Deficits in emotion control may be connected to physical and mental health consequences. This review aims to identify genetic variants, understand neurobiological mechanisms, and explore behavioral phenotypes associated with ER. In our study, we included English studies from online databases such as Web of Science, Cochrane Library, Google Scholar, PubMed, and Sco [...]

by Paul A. Barclay  and Clint A. Bowers

Received: 27 July 2018;  Published: 07 October 2018;  doi: 10.21926/obm.icm.1804024

(1) Background: Meditation is a common intervention for college students suffering from issues with anxiety. Due to this popularity, several meditation-based video games have been released which can be used to supplement or motivate meditation practice. However, these tools are not often given scrutiny in a laboratory setting before being released to the public. Our lab conducted a brief feasibility pilot study to investigate Meditation Deathmatch, an open-source meditation video game aimed at stimulating meditatio [...]

by Gérald Lopez

Received: 25 November 2020;  Published: 25 February 2021;  doi: 10.21926/rpm.2101005

Polymers such as polyimides and fluoropolymers are widely used for insulating aeronautic wires. They are exposed to various changing factors such as temperature, pressure, moisture, vibration, chafing, etc. The electrification on the horizon can potentially increase the demand for these systems. Indeed, this impending evolution of technology pushes the boundaries of commonly-employed wires. Downsizing systems and enhancing the performance is an urgent requirement. A new generation of insulating materials capable of [...]

by Michael Frass  and Katharina Gaertner

Received: 16 January 2019;  Published: 16 April 2019;  doi: 10.21926/obm.icm.1902023

This case reports of a 71-year-old patient with polycythemia vera (PCV). Homeopathic treatment began 15 years after his diagnosis at the age of 51. The frequency of phlebotomies was lowered significantly after the start of the homeopathic treatment; the patient survived another 16 years without chemotherapy, which he had rejected despite appropriate education. For someone with PCV who denied chemotherapy, this patient had a long survival time of more than 30 years, essentially enjoying good health and high quality [...]

by Behzad Foroutan

Received: 02 January 2023;  Published: 03 July 2023;  doi: 10.21926/obm.genet.2303185

The main purpose of this paper was to generate a narrative review related to the current knowledge of the TP53 gene and its product, the p53 protein. It was also attempted to elucidate the different p53 reactivation strategies of great interest, as various small molecules are being studied to reactivate mutant p53. PubMed and ScienceDirect were searched for p53, mutant p53, and wild-type p53 limited by the title filter through the end of 2022. The collected articles were studied, evaluated and summarized. In the sh [...]

by Nicole A. Bailey  and Laura Mackay

Received: 12 May 2024;  Published: 16 August 2024;  doi: 10.21926/obm.genet.2403256

Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism with an incidence that varies throughout the world. PKU is caused by loss of function variants in the phenylalanine hydroxylase gene. This loss of function leads to the accumulation of an amino acid, phenylalanine (Phe), that can reach toxic levels in the blood. PKU is managed with a medical diet and sometimes with medication. If diagnosed early and with strict dietary control, neurocognitive deficits can be prevented. There is an important [...]

by Andrew Villamil  , Talya Vogel  , Elli Weisbaum  and Daniel J. Siegel

Received: 03 October 2018;  Published: 16 January 2019;  doi: 10.21926/obm.icm.1901003

Research on the physiological and emotional health benefits of meditative practices has grown exponentially over the last two decades, influencing both scientific literature and popular media. Research has highlighted three distinct components or pillars at the core of meditative practices and mind training. They are, focused attention, open awareness, and kind intention. Neuroimaging studies and recent research highlight that the repeated practice of directing attention and awareness can enhance neural connections [...]

by Sarah-Catherine Rodan  , Phillip Aouad  , Iain S McGregor  and Sarah Maguire

Received: 08 April 2021;  Published: 24 June 2021;  doi: 10.21926/obm.neurobiol.2102102

Anorexia Nervosa (AN) is a major health problem with one of the highest mortalities and treatment costs of any psychiatric condition. Cognitive behavioural therapy (CBT) is currently the most widely used treatment for AN in adults but provides remission rates ≤ 50%. Treatment drop-out is exceedingly high and those that persevere with treatment often relapse, causing increased risk of morbidity and mortality. There is an urgent need to find new interventions, especially as there are no approved pharmacological treat [...]

by Anupa Pathak  , Saurab Sharma  and Mark P. Jensen

Received: 30 December 2019;  Published: 05 February 2020;  doi: 10.21926/obm.icm.2001005

There is a growing body of research evaluating the effects of hypnosis for the management of clinical pain. A summary of the recent systematic review would help understand the quality of evidence regarding the efficacy of hypnosis, and provide directions for future research. We conducted a scoping review of systematic reviews and meta-analyses on the efficacy of hypnosis for management of clinical pain conditions published after 2013. We searched four databases and two reviewers independently screened studies. We e [...]

by Igor Val Danilov

Received: 20 June 2023;  Published: 05 October 2023;  doi: 10.21926/obm.neurobiol.2304185

The theoretical article aims to develop knowledge about the modulation of shared intentionality at the cellular level. A hypothesis about the neurobiological processes during shared intentionality argues that this pre-perceptual communication occurs through nonlocal neuronal coupling in an ecosystem that can be described as the mother-fetus communication model. The current theoretical study analyses literature to discuss recent findings on the effect of oscillations on neuronal temporal coordination to verify wheth [...]

by Kim Lawson

Received: 05 November 2019;  Published: 20 January 2020;  doi: 10.21926/obm.neurobiol.2001049

Fibromyalgia, characterised by persistent pain, sleep disturbance, fatigue and cognitive dysfunction, is a central sensitivity syndrome that also involves abnormality in peripheral generators and in the hypothalamic pituitary adrenal axis. Heterogeneity of clinical expression of fibromyalgia with a multifactorial aetiology has made the development of effective therapeutic strategies challenging. Non-restorative sleep associated with poor sleep quality is a characteristic of fibromyalgia which is linked to symptom s [...]

by Kate McKeown  , Emma Richards  , Jessica Richardson  and Andrea Tales

Received: 08 January 2021;  Published: 07 June 2021;  doi: 10.21926/obm.neurobiol.2102100

Information processing speed (Reaction time, RT) to a single administration of the Trails A and Trails B components of the Trail Making Test (TMT) is used in the assessment of brain and behavioural functional integrity across the lifespan in both clinical and research contexts. Although the clinical utility of such single trial-related and thus rapidly gained results, is recognised, it is possible that its administration as a single trial only, precludes its ability to provide a more in-depth and thus relevant repr [...]

by Jyoti Bhattacharjee  and Subhasis Roy

Received: 17 February 2024;  Published: 09 August 2024;  doi: 10.21926/cr.2403011

The evolution of nanomaterials has been critical in modifying materials at the nanoscale for specialized uses. Carbon nanotubes were initially viewed as promising for electronics, but their inability to discriminate between semiconducting and metallic phases led to the creation of quasi-two-dimensional (Q-2D) materials. Molybdenum nanoparticles are utilized as alloy additions in corrosive and high-vacuum environments. Their characteristics differ significantly from those of their bulk counterparts. This review anal [...]