Epigenetics of Sleep Disruption
Abstract
1909 21684
Epigenetics of Sleep DisruptionAbstract
Sleep plays an important role in maintaining brain function, memory consolidation, hormonal balance, immune system function, growth, and repair. The physiological and psychological effects of disruptions in sleep highlight its importance in human health and wellness. Epigenetic roles are proposed in sleep, and circadian regulation, but only a limited number of studies have determined the mechanism that underlies the epigenetics of environmental factors interacting with the sleep, particularly the ones related to sl [...] 1909 21684 |
Thai Ethnomedicinal Plants Used for Diabetes Treatmentby
Abstract
Background: Diabetes is a metabolic disorder and a serious global health problem. Over 400 million people suffer from diabetes and it is estimated that the number will dramatically increase in the future. The cost of diabetes treatment for individual patients is very high. However, traditional knowledge could be used to support conventional diabetes treatments. Here, we identify medicinal plants that have been used as treatments for diabetes based on Thai ethnobotanical knowledge. Methods: We present a literature r [...] 3044 21665 |
A Review of the Multi-Physical Characteristics of Plant Aggregates and Their Effects on the Properties of Plant-Based ConcreteAbstract
The use of plant aggregates obtained from agricultural co-products mixed with mineral binders to form eco-friendly insulating building materials has been initiated for a few years to bring environmentally friendly solutions to the construction sector. Several studies on different agro-resources have already been carried out, providing various information about the properties of plant aggregates and plant-based concrete. However, the characteristics of the agricultural co-product, which allow it to qualify as a plan [...] 2602 21642 |
Kidney Transplantation in Nigeria: A Single Centre’s Early Surgical Experience and Outcomesby
Abstract
With the rise in the population of patients with End-stage Renal Disease (ESRD) in Nigeria, there is an increased demand for Renal Replacement Therapy (RRT) including kidney transplantation (KT). We present our initial surgical experience and early outcomes with KT at a Nigerian transplant center over 2 years. A 2-year retrospective review of patients who underwent KT was done. Data of both kidney donors and recipients were recorded in designed proformas. Extracted information included demographic characteristics, [...] 2472 21524 |
Behavioural and Complementary Interventions for Healthy Neurocognitive AgingAbstract
Background: While the percent of persons 65 and older is expected to increase to 17% of the world’s population by 2050, this increase in longevity does not necessarily suggest a parallel increase in health status. While aging is an inevitable aspect of living, there are factors which can accelerate morbidity and mortality, as well as factors likely to promote a healthy transition into longevity. This paper addresses behavioural and complementary interventions for healthy neurocognitive aging. Specific evidence-base [...] 3605 21476 |
EnergyPlus-Towards the Selection of Right Simulation Tool for Building Energy and Power Systems ResearchAbstract
This article offers the summary of detailed literature review on the state of the art of simulation tools for building energy and power system research. The fundamental capabilities required for building energy and power system analysis tools are outlined. A comparative review of different energy simulation tools is presented, along with the summary of their strengths and weaknesses. A review of energy simulation tool rankings using evidence-based research is presented. A novel aspect of this article is the investi [...] 3781 21474 |
Optimizing Lymphedema Outcomes through Lifestyleby
Abstract
Lymphedema, a chronic incurable condition characterized by edema, inflammation, reactive fibrosis, adipose proliferation, and compromised immune function, affects over 250 million people worldwide [1]. Further, a comorbidity of obesity increases the risk of developing lymphedema and can result in irreversible damage to lymphatic function. Access to appropriate and timely lymphedema treatment, performance of proper self-management strategies, and implementation of healthy lifestyle practices are critical for optimal [...] 1451 21464 |
Does Intensive Mindfulness Training Strengthen Sustained Attention? Examining Individual Differences in Mind Wandering during the Sustained Attention to Response Taskby
Abstract
Mindfulness training (MT) has been shown to benefit sustained attention and mind wandering. Yet, few studies have examined whether benefits differ as a function of individual differences in mind wandering. The sustained attention to response task (SART) measured task accuracy (A'), response time variability (response time intraindividual coefficient of variation, ICV), and self-reported mind wandering in participants before (T1) and after (T2) a 1-month MT retreat (n = 56), as well as in a control group (n = 32) wh [...] 1687 21377 |
Examining the Effectiveness of Two Types of Forgiveness Intervention to Enhance Well-Being in Adults from Young to Older AdulthoodAbstract
Background: Interventions that facilitate positive actions and attitudes seem to play an important role in enhancing psychological health. This study examines the effectiveness of two self-guided interventions with the aim to enhance adults’ well-being through the cultivation of forgiveness skills. Methods: A total of 11 men and 31 women aged 34-80 years were involved (M = 56.57, S.D. = 13.44). All participants were Orthodox Christians, as the average Greeks are, without belonging to a closed religious community. T [...] 2035 21312 |
Interactions of Per- and Polyfluoralkyl Substances (PFAS) with Landfill Linersby
Abstract
This review synthesises the available published research on interactions of per- and polyfluoroalkyl substances (PFAS) with landfill liners, with the view to inform on the expected behaviour of these persistent environmental pollutants in landfills. The review addresses the nature and significant types of PFAS compounds that are destined for landfills, as well as their by-product. It discusses the known and anticipated interactions with separate landfill liner components, namely geomembranes, geosynthetic clay line [...] 4007 21308 |
Why the Quantum Brain?Abstract
This article reviews the modern approaches to the quantum brain hypothesis. The aim is to consider the hypothesis and its classical brain-machine alternative from a broad perspective, including physics, biology, computer science, cosmology, and metaphysics. My starting point is that asking whether consciousness can or cannot have free will is fundamentally incorrect. This aspect is challenged by both physics and neuroscience. The paper argues that the search for conscious free will, as it is typically tested in Lib [...] 2156 21299 |
Non-Invasive Brain Stimulation for Insomnia - A Review of Current Data and Future ImplicationsAbstract
Neuroimaging evidences point to the role of hyperarousal in the pathophysiology of insomnia. While actual treatments fail to directly target brain hyperarousal, emergent complementary therapies known as neuromodulation techniques aim to improve sleep in people with insomnia by targeting irregularities in their brain activity. In this paper, we narratively review the most relevant studies reporting the application of neuromodulation techniques to improve sleep in individuals with insomnia. Using a non-systematic app [...] 3172 21201 |
Fuel-Briquetting for Sustainable Development in Developing Countries-A ReviewAbstract
This review covered recent research products on fuel-briquette with emphasis on its production technologies and physical characteristics involving shapes, volumes, resiliencies, and mechanical compressive strengths; combustion properties such as high heating values, volatile matters, moisture contents, ash contents and fixed carbon; chemical analyses for the content of components such as nitrogen, hydrogen, sulfur, oxygen and carbon; emission characterization such as and economic potentials. This review provides op [...] 1859 21167 |
Developing Self-Compassion Online: Assessing the Efficacy and Feasibility of a Brief Online InterventionAbstract
The aim of the study was to assess the efficacy and feasibility of a newly designed online self-compassion training programme for the general public. Two hundred and forty-nine participants were randomly assigned to have either immediate or delayed access to a four-week online self-compassion training programme. This programme was based on Compassionate Mind Training and was made up of psychoeducational sessions and in-between session practices and readings. Out of the 179 participants who completed the pre-interve [...] 2504 21151 |
Dimensional, Mechanical and LCA Characterization of Terrazzo Tiles along with Glass and Construction and Demolition Waste (CDW)by
Abstract
In this work, two types of wastes were introduced, namely, glass from municipal waste and Construction and Demolition Waste (CDW). The latter, which was obtained from rubble generated by the seismic events occurred in Central Italy in 2016, was introduced in two configurations, the single-layer and the double-layer of the cement-based Terrazzo tiles. A maximum of 77% of waste introduction was proven to be possible, therefore creating the possibility of obtaining construction products including high quantities of se [...] 2547 21115 |
Take a Seat for Yoga with Seniors: A Scoping Reviewby
Abstract
Chair yoga is a specific form of yoga practiced while seated on a chair, or standing using a chair for support; this adaptation allows those with impaired standing ability to practice safely. The purpose of this scoping review was to analyze the published literature regarding the use of chair/adapted yoga with older adults. Two researchers performed the review. Data sources: PubMed Central, CINAHL, Medline Full Text, Nursing and Allied Health, SPORT discus and TRIP were accessed. Study selection: Inclusion criteria [...] 1800 21039 |
Kinetic Modeling of the Esterification of Oleic Acid and Methanol in Conventional and Adsorptive Reaction SystemsAbstract
Biodiesel is derived from renewable vegetable or animal sources and is either used as a standalone fuel or blended with oil-based diesel. The kinetic mechanism of the esterification of oleic acid was investigated in a conventional batch reactor and a batch reactor coupled to a water adsorption system. The esterification was performed with oleic acid and methanol at different temperatures (70 to 110 °C) and alcohol-to-oleic acid molar ratios (3:1 to 9:1), using sulfuric acid as a catalyst. A kinetic model was constr [...] 4370 21015 |
Wind Turbines for Decarbonization and Energy Transition of Buildings and Urban Areas: A Reviewby
Abstract
The recent tendencies of drastic variations of environmental conditions, inundations, severe winds, and gusts besides heavy and unexpected long-duration rains showed the world an image of what could happen if emissions and global warming are not adequately controlled. Implementing new energy solutions as fast as possible is essential to cope with climate change, one of the biggest threats to our survival. These alarming signs intensified research and development efforts to replace fossil-based activities with renew [...] 1607 20944 |
Engineering Bacterial Cellulose for Diverse Biomedical ApplicationsAbstract
Increasing interest in bacterial cellulose due to the huge potential which exists for the development of this new biomaterial for medical applications has been met with recent growth in research in engineering this unique microbial manufactured material. The mechanical properties, porosity, and biocompatibility of bacterial cellulose derived biomaterials are particularly attractive for use in wound healing, tissue engineering, and drug delivery applications. Advances in synthetic biology and soft materials engineer [...] 2962 20883 |
Newborn Screening for Classic Galactosemia: Biochemical Testings, Challenges, and Futureby
Abstract
Galactosemia is a group of hereditary disorders of galactose metabolism. Newborn screening for galactosemia type I is mandatory in all states in the US since timely intervention can prevent life-threatening sequela. The biochemical basis, clinical presentation, and potential treatment options for different types of galactosemia are described. This review has a focus on the screening methodologies, including the principle of the assay, the transition from the initial bacteria inhibition test to the modern fluorometr [...] 2007 20859 |
Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic PerspectiveAbstract
Progress in technologies, notably in vivo and in situ methods, has equipped scientists with the necessary skills to explore the living human body in increasingly minute detail. This has led to a better understanding of the dynamic interplay between the various elements that make up the living human body. To further understand the interplay, this research focuses on the insights and observations of the founders of osteopathy, who placed great importance on the role of fascia in the body. Modern anatomical investigat [...] 2081 20830 |
Quality Assurance/Quality Control of Fluorescence in Situ Hybridization Tests in Hematologic MalignanciesAbstract
Because of its’ simplicity, reliability and cost-effectiveness, fluorescence in situ hybridization (FISH) is a major technology that is widely applied in clinical diagnosis, especially for hematologic malignancies, even in the era of next-generation sequencing (NGS). In the Clinical Cytogenetics Laboratory at MD Anderson Cancer Center, over 15,000 FISH tests are performed each year, including approximately 1,000 BCR-ABL1 and 500 MYC FISH tests, respectively. In this chapter, we introduce the quality assurance/quali [...] 3133 20804 |
The Effects of Exercise on Long-Term Potentiation: A Candidate Mechanism of the Exercise-Memory RelationshipAbstract
Objective: The objective of this paper was to evaluate the extent to which exercise may influence long-term potentiation (LTP), a key cellular correlate of episodic memory function.
Methods: Studies were identified using electronic databases, including PubMed, PsychInfo, Sports Discus and Google Scholar.
Results: The computerized searches revealed 20 articles meeting the study criteria. Among these 20 evaluated articles, 17 were conducted in an animal model and 3 among humans. All 17 of these studies, with the exce [...] 2489 20802 |
Neuroplasticity and Central Sensitization in Orofacial Pain and TMDAbstract
Temporomandibular disorders (TMD) are a group of musculoskeletal and neuromuscular conditions that involve the temporomandibular joint (TMJ), the masticatory muscles, and branches of the trigeminal nerve. TMD is the most common chronic oral facial pain disorder. Pain associated with TMD can be clinically expressed as myogenous or arthrogenous in etiology. The myogenous variant of TMD is characterized by pain in the muscles of mastication. The arthrogenous form of TMD is caused by pain in the joint leading to synovi [...] 2229 20789 |
Neuroprotective Strategies in Glaucoma - Translation to Clinical TrialsAbstract
Neuroprotection in glaucoma is any medical treatment by which decline in visual function can be slowed or prevented by supporting the health and survival of neural cells, independent of lowering of intraocular pressure (IOP). This is achieved by targeting mechanisms to inhibit or delay retinal ganglion cell death and promote cell survival pathways. Despite demonstrating promising results in preclinical trials, many neuroprotective strategies have failed to show success in subsequent clinical trials. Of the clinical [...] 2271 20776 |
An 800V End to End SiC Powertrain to Accommodate Extremely Fast Chargingby
Abstract
Widespread adoption of electric vehicles has presented the challenges of short range and prolonged charging time. Going forward, extremely fast charging is the only solution to these problems. However, the typical Silicon power electronics supported 400 V electric vehicle powertrain cannot live up to this challenge. Limitations include the huge cable size, heating of equipment due to high current and user safety, to name a few. In this paper, we have analyzed an 800 V EV powertrain using power electronics based on [...] 3675 20774 |
Development of the Flash Ironmaking Technology (FIT) for Green Ironmaking with Low Energy ConsumptionAbstract
This article describes the development of a novel ironmaking technology based on flash reduction. The development started with the proof of the kinetic feasibility, considering that a typical flash reactor provides only a few seconds of residence time. This was followed by tests in a laboratory flash reactor and finally a pilot plant operation. The rate equations formulated in this work were developed considering the optimum combination of temperature, residence time, and reducing gas partial pressure to achieve [...] 3020 20722 |
The Safety of Oral Telomerase Activator in UV-Induced Skin Cancer with A Review of Telomerase in Aging and Skin CarcinogenesisAbstract
The supplement telomerase activator TA-65 (purified from Astragalus membranaceus) has been shown to retard cellular senescence, boost the aging immune system, and retard age-related symptoms. Lengthened telomeres retard aging, but because cancers often maintain longevity by lengthening telomeres, dietary telomerase activator might possibly increase tumorigenesis. This study investigated whether oral TA-65 effects the timing of onset and/or the incidence of skin cancers induced by UVB-irradiation and whether that po [...] 1331 20714 |
Obesity and Non-Alcoholic Fatty Liver - Therapies in Ayurvedic MedicinesAbstract
Ayurveda is an ancient Indian medicinal practice. The present review includes translational research characterizing obesity, non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).
We reviewed published research on improving function through Ayurvedic medicine by searching electronic databases (Medline, Embase) using terms such as: Ayurveda, obesity, NAFLD, NASH, the effect of exercise interventions in obesity, change in body composition. We aim to (1) determine the immuno-pathology of [...] 2145 20667 |
Electroporation-Based Non-Viral Gene Delivery to Adipose Tissue in Miceby
Abstract
Adipose tissue is distributed throughout the body as fat depots. The amount of adipose tissue increases with age. In mice, epididymal fat depots in males and gonadal fat depots in females are associated with the reproductive system. Regarding fat depots in females, the adipose tissue under the skin can be easily exposed via surgery when the ovary, oviduct, and uterus are pulled out and exposed. As handling adipose tissue is relatively easy, adipocytes might be good targets for genetic manipulation (including gene d [...] 2398 20609 |
The Beneficial and Adverse Effects of PhytoestrogensAbstract
The most well-known phytoestrogens (flavonoids, isoflavonoids, lignans, coumestans, stilbenes, and prenylflavonoids) are isoflavonoids, which are important active ingredients in medicinal and food plants. They are highly abundant in the Fabaceae family. More than 1,000 types of isoflavonoids have been isolated from nearly 300 kinds of plants, and more are being discovered through modern analytical methods. Glycosides O and C of isoflavonoids are poorly absorbed in the intestine. They are converted by bacterial este [...] 2525 20607 |
Toward Next Generation Plasmonic Nanopore Slit Platform with a ~10 nm Slit-Widthby
Abstract
We fabricated various nanoaperture plasmonic platforms for single-molecule detection. We fabricated nanoapertures like nanopores on a pyramid and nanoslits on an Au flat membrane using a Ga ion focused ion beam drilling technique, followed by irradiating with a high energy electron beam, dependent on the electron beam current density to obtain nanoapertures with a few nanometer sizes (circular nanopore, nanoslit pores). We examined their optical characteristics with varying aperture sizes and sample thicknesses. We [...] 7169 20569 |
Biomedical Applications of Wrinkling PolymersAbstract
Advancements in surface engineering and material fabrication techniques have enabled the creation and replication of naturally occurring surface topographies or the extrapolation of natural patterns to become achievable targets. Polymers are used extensively in the field of biomedical sciences for containment, handling, and as cell culture substrates. It is well established that several polymers exhibit good biocompatibility for cell culture, with properties that include exhibiting minimal to no cytotoxicity and be [...] 2670 20535 |
Open-Label Study to Evaluate the Response to Homeopathic Treatment of Psoriasisby
Abstract
Patients with psoriasis commonly opt for homeopathic treatment. However, no study has assessed the response to homeopathic treatment by using standardized disease-specific scales, and the findings are based on clinical assessments only. The objective of this study was to evaluate the response to the individualized homeopathic treatment of psoriasis with respect to changes in disease severity and quality of life based on Psoriasis Area and Severity Index (PASI) and Psoriasis Disability Index (PDI) scales, respective [...] 2294 20520 |
COVID-19 (Coronavirus Disease-19): Traditional Chinese Medicine including Acupuncture for Alleviation – A Report from Wuhan, Hubei Province in Chinaby
Abstract
Traditional Chinese Medicine (TCM) has been used to prevent and alleviate epidemic diseases for hundreds of years. The combination of TCM and Western medicine can effectively reduce fever; alleviate cough, fatigue, diarrhoea and other symptoms of patients with mild COVID-19 (Coronavirus disease-19). For the treatment of moderate and severe syndromes, the integrative approach can reduce lung exudation and inhibit the further development of the disease. However the risk of infection is a limit for example in needle a [...] 3234 20450 |
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Open Access Short Communication Topical Probiotics for Women’s Urogenital Health: Selection of an Oil-based CarrierAbstract
Vaginal care products are widely used by women to relieve discomfort such as pain, itching and malodour, all of which are commonly caused by conditions resulting from microbiota dysbiosis. Previous studies showed that probiotic strains Lacticaseibacillus (formerly Lactobacillus) rhamnosus GR-1 (LGR-1) and Limosilactobacillus (formerly Lactobacillus) reuteri RC-14 (LRC-14), can aid in restoring homeostasis in the vaginal microbiome when taken orally. A topical product containing these strains could be of value for r [...] 2096 20440 |
Using Additives to Control the Decomposition Temperature of Sodium BorohydrideAbstract
Hydrogen (H2) shows great promise as zero-carbon emission fuel, but there are several challenges to overcome in regards to storage and transportation to make it a more universal energy solution. Gaseous hydrogen requires high pressures and large volume tanks while storage of liquid hydrogen requires cryogenic temperatures; neither option is ideal due to cost and the hazards involved. Storage in the solid state presents an attractive alternative, and can meet the U.S. Department of Energy (DOE) constraints to find m [...] 4508 20420 |
Emerging Progress in Nanotechnological Influence on Polymeric Textile Finishingby
Abstract
Nanotechnology has revolutionized the textile industry by introducing innovative finishing techniques that enhance the durability and performance of textile materials and the application of nanoscale/nanoparticles/nanomaterials and processes to improve the properties and performance of textiles. The synergism of textile technology and nanotechnological advancements has propelled a paradigm shift, changed the narrative, and formed novel platforms for textile surface engineering at both atomically affiliated and mole [...] 2519 20416 |
Dysphagia in the Elderly, A Tough Issue to SwallowAbstract
Dysphagia in the geriatric population, age 65 or older, is increasingly common and a growing concern among healthcare providers. Not only can it critically impact quality of life, but it can also lead to clinically significant malnutrition, hospitalizations, increased length of stays, and has been shown to impact mortality. A multi-disciplinary approach to assess oral, pharyngeal, and esophageal etiologies is key to guiding targeted management, which can include behavioral modifications, medications, and endoscopic [...] 3622 20381 |
GIS-based MCDM Approach for Wind Farm Site Selection - A Case StudyAbstract
The objective of this study is the development and implementation of a geographic information system (GIS)-based methodology to determine suitable sites for wind farms by using multicriteria decision making (MCDM) techniques. Many eligibility criteria are considered in this approach, such as GIS analysis is performed in combination with MCDM techniques, both for the criteria weighting process (using the analytical hierarchical process) and for the standardization/classification of the criteria values into a common [...] 2202 20377 |
An Open Source LoRa Based, Low-Cost IoT Platform for Renewable Energy Generation Unit Monitoring and Supervisory ControlAbstract
SCADA provides real-time system monitoring by constant communication and data exchange between various system devices to achieve data visualization and logging. Presently, in industrial systems, commercial SCADA systems are being used for data monitoring and control. These systems can be expensive, and as such can only be afforded by select industries. Even at these costs, the commercial SCADA systems face some challenges, which include interoperability and scalability issues. Research has shown that these problems [...] 1785 20324 |
The Value Given and Presupposed in Person-Centred Dementia Careby
Abstract
Thirty years ago, Tom Kitwood proposed a change in the care of people with dementia, from ‘warehousing’ to ‘person-centred care’. The change had noticeable benefits for those with dementia. Kitwood set out his presuppositions for this change. For example, Kitwood understood personhood as the standing or status bestowed on one human being by others in the context of relationships and social being and held that respect for the absolute value of each person is a key theme in Western ethical discourse. He was clear thi [...] 2359 20290 |
The Use of Biomaterials in Internal Radiation TherapyAbstract
Radiotherapy has become one of the most prominent and effective modalities for cancer treatment and care. Ionising radiation, delivered either from external or internal sources, can be targeted to cancerous cells causing damage to DNA that can induce apoptosis. External beam radiotherapy delivers either photon radiation (x-rays or gamma rays) or particle radiation (neutrons or protons) in a targeted manner to specific tumour locations. Internal radiotherapy involves placing radioactive sources within the body to de [...] 2742 20284 |
Wisdom and Curiosity Among Older Learners: Elucidating Themes of Well-Being from Beautiful Questions in Older Adulthoodby
Abstract
Background: Wisdom and curiosity require greater attention in the lifelong learning literature pertaining to older adulthood. Lifelong learning can assist older adults in amalgamating wisdom and pursuing their curiosities, but how wisdom is amalgamated and how curiosity is pursued in older adulthood needs more exploration. Methods: This qualitative study investigates subthemes of wisdom amalgamation and curiosity pursuits elucidated from interviews of older adults who participated in a university-based lifelong lea [...] 2271 20272 |
The Effectiveness of Using Progressive Muscle Relaxation Techniques on Quality of Life, Stress, And Anxiety Among Acute Myocardial Infarction: A Systematic ReviewAbstract
The progressive muscle relaxation technique (PMRT) is an active method that is defined as a technique through which individuals gradually cause a feeling of quietness and coolness by actively contracting and loosening specific muscle groups. The purpose of this study was to review the effectiveness of using progressive muscle relaxation techniques on quality of life, stress, and anxiety levels among Acute Myocardial Infarction patients. A systematic review of randomized controlled trials (2013-2023). Databases of P [...] 2095 20238 |
Overview of Practical Applications of Healthcare Ethics for Older Adultsby
Abstract
Identifying and addressing ethical issues in the care of older adults can be complex and challenging in clinical settings. This article reviews specific ethical principles including autonomy, beneficence, non-maleficence, dignity, and justice, and explores them in the context of interprofessional geriatric care. Situations and related ethical components such as treatment in intensive care units, end-of-life care, dementia care, and aging with advancing technology are included. Case scenarios for each principle or s [...] 2823 20221 |
A Systematic Literature Review on the Efficacy of Emerging Computer Technologies in Inclusive Education for Students with Autism Spectrum Disorderby
Abstract
Including learners with autism spectrum disorder (ASD) in mainstream classrooms is associated with challenges that could impede their academic participation. However, studies have shown the value of inclusive education, especially when supported with computer technologies, learners with ASD can effectively learn alongside their non-autistic peers. Despite that, there has been minimal research on ASD inclusion with emerging computer technologies. This paper presents a systematic review of the literature on the appli [...] 2544 20216 |
Craniopharyngiomas: An Appropriate Surgical Treatment based on Topographical and Pathological Conceptsby
Abstract
The optimal treatment of craniopharyngiomas (CPs) represents a neurosurgical challenge, the major reason being their close relationship with the hypothalamus and the third ventricle (3V) boundaries. Nevertheless, CPs are generally defined as “suprasellar” lesions, an inexplicit and frequently defective term. Despite being heterogeneous lesions, CPs are actually characterized by repeating pathological patterns which depend on their point of origin along the pituitary-hypothalamic axis. Surgical plan in tailoring the [...] 2285 20178 |
Achieving Net Zero Through a Multi-Dimensional Approach to Carbon Management in Mining and Metals Processing–A Case Study of Rio Tintoby
Abstract
The earth’s climate is warming, increasingly straining the Earth’s human and environmental systems. Organisations are increasingly committing to net zero emissions by mid-Century to set and communicate their ambition to limit global warming to the peak temperature goals of the Paris Agreement. However, for many companies, the pathway to delivering against this ambition remains unclear – and significant investment in technical, social and economic systems required before this target becomes a reality. This paper ana [...] 1998 20174 |
Preimplantation Genetic Testing for HLA-matching: An Overview of Clinical Application and UtilityAbstract
Preimplantation Genetic Testing for HLA-matching (PGT-HLA) has been one of the most controversial PGT applications, first reported in 2001. The procedure aims to identify an embryo that is not only healthy but also HLA-matched with a sibling in the family in need of haematopoietic stem cell transplantation (HSCT), considering that sibling HSCT stands the highest chance of success in comparison to alternative approaches. HLA-typing can be performed with or without PGT-M for the exclusion of a single-gene disorder. T [...] 2135 20173 |
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