by Jacques Muzart

Received: 10 October 2019;  Published: 08 January 2020;  doi: 10.21926/acr.2001003

This article summarizes some surprising palladoreactions occurring in a transition metal environment, discovered by our team, and the proposed corresponding mechanisms.

by Xiaoli Li  , Kendall Brune  , Jean Keller  , Jennifer Stelter  and Stan Ingman

Received: 23 August 2022;  Published: 25 June 2023;  doi: 10.21926/obm.geriatr.2302239

Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A sur [...]

by Edwin Meresh  , Clinton Korneffel  , Bavani Rajah  and Ryan Bergren

Received: 23 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101089

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Symptoms lasted severa [...]

by Zaid Albayati  , Sally Heyworth  , Jane Moberly  , Derek Middleton  , Brian Flanagan  , Abdul Hammad  and Stephen E Christmas

Received: 10 October 2018;  Published: 14 December 2018;  doi: 10.21926/obm.transplant.1804032

Background:HLA-G is an immunosuppressive molecule with a potential role in allograft acceptance. Methods:Expression of HLA-G on leucocyte subpopulations was studied in a group of 21 renal transplant patients immediately prior to and 2 months post-transplantation. Results:Significant increases in proportions of total HLA-G+CD4+ T cells were seen (0.5+/-0.1% to 7.9+/-3.2%; p<0.01) and also for CD45RA+, CD45RO+ and CD69+ subsets. Increases in proportions of HLA-G+ cells were also seen in CD8+ T cells and their [...]

by Paola Romecín  , Joaquin García-Estañ  and Noemí M. Atucha

Received: 15 May 2019;  Published: 01 November 2019;  doi: 10.21926/obm.hg.1904039

(1) Background: Platelet function is commonly altered in liver cirrhosis. In experimenta models of liver cirrhosis we have analyzed the mechanisms of this defective function. (2) Methods: Experiments were performed in a model of liver cirrhosis by bile duct-ligation in washed platelets by means of fluorescence spectroscopy with fura-2. (3) Results: We have found several alterations compatible with the existence of a hyperaggregatory state. These alterations are related to a defective platelet calcium handling, spec [...]

by Aminata Bicego  , Pauline Delmal  , Didier Ledoux  , Marie-Elisabeth Faymonville  , Benoît Maertens de Noordhout  , Alfredo Cerasoli  , Héléna Cassol  , Olivia Gosseries  and Audrey Vanhaudenhuyse

Received: 29 June 2022;  Published: 09 September 2022;  doi: 10.21926/obm.icm.2203040

Phantom limb pain occurs in more than half of the people who have undergone an amputation. Hypnosis can alleviate pain effectively in experimental, procedural, and chronic pain. Thus, in this multiple-case study, we determined whether hypnosis might be a successful complementary approach to help patients with phantom limb pain in alleviating their pain quality (i.e., sensitive and affective), intensity, fatigue, and emotional distress (i.e., anxiety and depression). Seven patients experiencing phantom limb pain wer [...]

by Sheila Krishnan  , Chadi Hage  , Raymond Coakley  , David van Duin  and Leonard Jason Lobo

Received: 18 February 2019;  Published: 10 June 2019;  doi: 10.21926/obm.transplant.1902065

Lung transplant recipients are at greater risk of respiratory viral infections as compared to other solid organ transplant recipients due to constant exposure of the allograft to the external environment. There are no standardized methods for surveillance, prevention, or treatment of these infections despite their association with increased morbidity and mortality. Various studies have linked respiratory viral infections with acute cellular rejection and chronic allograft dysfunction, and emerging data indicates a [...]

by Masahiro Sato  , Yuki Kiyokawa  , Emi Inada  , Eri Akasaka  , Satoshi Watanabe  and Issei Saitoh

Received: 15 March 2021;  Published: 04 November 2021;  doi: 10.21926/obm.transplant.2104155

Although the aging process expands the adipose tissue habitation in mice and due to its close association with the female reproductive system, it can be easily exposed surgically under anesthesia when reproductive organs (including ovary, oviduct, and part of the uterus) are pulled and exposed onto the dorsal skin. This study aimed to consider the suitability of adipose tissue as a target for manipulation, particularly for the grafting of cells or small-sized tissue sections due to its ease of handling. Subsequentl [...]

by Fabio Robusto  , Giovanni Colucci  , Maria Zamparella  , Enrico Maria Pellegrini  , Brigida Martucci  , Pasquale Iacovazzo  , Enza Colucci  , Martino Minardi  , Cristina Giliberti  , Vito Bossone  , Vito Lepore  and Stefano Ivis

Received: 08 September 2021;  Published: 04 March 2022;  doi: 10.21926/obm.geriatr.2201192

Frailty is a chronic condition that increases the vulnerability to stressogenic factors and prevents the patient from returning to the preceding condition of homeostasis. This increases the risk of negative outcomes and progressively brings the patient toward disability, leading to higher use of healthcare resources. Clinical risk stratification systems can generally be useful for identifying frail patients from the standpoint of a healthcare system, though General Practitioners (GPs) assume a key and irreplaceable [...]

by Alyssa M. Krueger  , Kelsey Smith  , Arielle Pollock  , Christine Dunkel Schetter  and Nicole E. Mahrer

Received: 24 December 2023;  Published: 30 April 2024;  doi: 10.21926/obm.icm.2402025

Residential and nonresidential fathers are taking an increasingly greater role in their children’s lives, and father involvement predicts positive child outcomes across development. This study utilized data from a large sample of racially and ethnically diverse fathers of low to middle income (n = 1,112) to test if paternal stress is associated with lower father involvement in early infancy and whether perceived social support is protective. Exploratory analyses examined whether the effects of stress on father invo [...]

by Victoria Gómez-Dos-Santos  , Vital Hevia-Palacios  , Edurne Ramos-Muñoz  , María Laura García-Bermejo  , Esperanza Macarena Rodríguez-Serrano  , Ana Saiz-González  , Jose Manuel Del Rey-Sánchez  and Francisco Javier Burgos-Revilla

Received: 22 March 2018;  Published: 21 June 2018;  doi: 10.21926/obm.transplant.1802012

Background: Extended criteria donors and donation after cardiac death donors provide organs which tend to be more sensitive to the stress of preservation. There is a lack of evidence about the potential role of oxygen in preservation techniques, and literature comparing oxygenated and non-oxygenated techniques is very limited. The aim of the study was to compare HMP with oxygen versus HMP without oxygen in a pig model of kidney auto-transplantation (KT) reproducing conditions of DCD. We have also set up miRNAs expr [...]

by Jiarui Fang  , Ziheng Li  , Xiruo Bai  , Yichu Zhang  , Jiahui Liu  , Dan Wang  and Ye Yao

Received: 10 May 2022;  Published: 04 July 2022;  doi: 10.21926/cr.2203018

TiO2 (001) crystal plane exhibits molecular adsorption and photocatalytic activity. The loading capacity of reactive oxygen species present on crystal planes helps in the significant improvement of catalytic activity. The methods of synthesis and conditions of existence significantly affect the molecular adsorption properties of crystal planes, which in turn affects the ability of the system to load reactive oxygen species. Herein, we report the simulation of the molecular adsorption behavior on the TiO2 (001) usin [...]

by Andrey Nasledov  , Sergey Miroshnikov  , Liubov Tkacheva  and Sergey Fedorov

Received: 08 June 2023;  Published: 19 October 2023;  doi: 10.21926/obm.neurobiol.2304190

The study aims to reveal autism vectors that are inherent in 3-4-year-olds with ASD. Three hundred eighty-three children with ASD took part in the research. An online questionnaire developed earlier by our research group was used. In the first stage, with the repeated use of exploratory factor analysis, the task of identifying the simplest factor structure was solved. As a result, a 7-factor system was obtained, including from 9 to 14 items in each factor (78 items in total): 1) "Persistence on sameness" (Sam); 2) [...]

by Lin Xie  and Donald Kirk

Received: 09 June 2021;  Published: 16 September 2021;  doi: 10.21926/cr.2103003

Fe-rich alloys have been widely studied as catalyst materials for the cathodic oxygen reduction reaction (ORR) in hydrogen fuel cells, and many have shown high activities. The stability of Fe-rich catalysts has also been researched, and some studies have shown promising results using an accelerated stress test (AST), which uses a potential cycling method. However, for commercial fuel cell applications, such as standby power systems, the catalyst has to tolerate a high potential for a long period, which can not be r [...]

by Rebecca MacDonald  and Anna Zumbansen

Received: 26 February 2023;  Published: 13 June 2023;  doi: 10.21926/obm.icm.2302024

Group singing as a social musical activity can be used to improve the quality of life, well-being, and overall health of people with dementia and caregivers. Online choirs have gained awareness since the COVID-19 pandemic; however, singing in an online choir is an unsatisfying experience for most choir members in the general population. In order to report on the feasibility of creating an online choir for people with dementia, we studied a successful case of such a choir. This choir began and continued online for o [...]

by Claire Sanderson  and Paul D. Loprinzi

Received: 15 July 2019;  Published: 09 October 2019;  doi: 10.21926/obm.neurobiol.1904043

Objective: Reversal learning requires an individual to alter their behavior when previously learned reward-based contingencies are reversed. Reversal learning is heavily influenced by cognitive flexibility, which has been shown to be enhanced with acute exercise. However, minimal work has directly evaluated the effects of acute exercise on reversal learning, which was the purpose of this experiment. Methods: A between-subject randomized controlled intervention was employed. Participants (N=60) were randomized into [...]

by Ana Valado  , Polina Ponedilok  , Armando Caseiro  and Leonel Pereira

Received: 22 July 2023;  Published: 29 November 2023;  doi: 10.21926/rpn.2304024

Noncommunicable diseases (NCD), such as cardiovascular diseases (CVD), are responsible for the majority of annual deaths worldwide. Dyslipidemia, hypertension, diabetes, and obesity, among others, can enhance the onset of metabolic syndrome (MetS). The integration of natural products in the diet, such as marine macroalgae or hydrocolloids extracted from them, has been extensively studied. The application of these substances in the prevention of pathologies is expanding due to the high content of bioactive compounds [...]

by Sylvaine You  and Lucienne Chatenoud

Received: 25 September 2018;  Published: 09 November 2018;  doi: 10.21926/obm.transplant.1804025

Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in the induction and maintenance phases of immune tolerance. Intensive investigations have shed light on the tolerogenic networks underlying graft survival and have unraveled their complexity, which may depend on several p [...]

by Mahintaj Dara  , Negin Shafieipour  , Mahsa Saffar  , Mehdi Dianatpour  , Seyed-Mohammad-Bagher Tabei  and Seyed-Alireza Dastgheib

Received: 18 November 2024;  Published: 01 April 2025;  doi: 10.21926/obm.genet.2502289

Since the initial discovery of the CRISPR system in bacteria as an adaptive immune system, a deeper understanding of CRISPR structure and function has made it possible to perform gene editing, gene therapy, and revolutionize the diagnostic field. One of the exciting applications of the CRISPR-Cas system is used as a tool for the rapid diagnosis of infectious diseases and their treatment and the prevention of infection spread among people. The CRISPR-based diagnostic system could be the next-generation standard beca [...]

by Sofia Silva  , Alexandra Cravo  , João Rodrigues  , Cátia Correia  and Cristina M.M. Almeida

Received: 09 April 2021;  Published: 19 June 2021;  doi: 10.21926/aeer.2102015

The use of biomarkers in bivalves has gained significance as a reliable method for the assessment of the presence and effect of contaminants in aquatic ecosystems. However, it is important to note that the biomarkers respond not only to contaminant loadings and bioavailability but also to environmental stress. Therefore, the association between biomarkers and contamination/pollution should be conducted cautiously as the environmental factors also affect their response. These factors should be integrated into the as [...]

by Alina Wong  and Scott D Lee

Received: 09 May 2019;  Published: 16 August 2019;  doi: 10.21926/obm.hg.1903033

Crohn’s disease is characterized by chronic intestinal inflammation that can result in significant morbidity and loss of intestinal function over time. Many novel treatments for Crohn’s disease are being developed, but a significant portion of patients still requires surgical therapy for structuring or penetrating disease. While the utility of esophagogastroduodenoscopy and ileocolonoscopy in inflammatory bowel disease patients is well established, new endoscopic techniques are being developed to help evaluate prev [...]

by Meir Djaldetti  , Chiya Moshe Leibovitch  and Hanna Bessler

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased produc [...]

by Rolf Teschke  , Nguyen Xuan Chien  and Tran Dang Xuan

Received: 10 June 2025;  Published: 21 October 2025;  doi: 10.21926/rpn.2504023

Heavy metals are integral parts of our environment, originating initially from the universe and used in the industry, which may contribute to pollution. This book chapter aims to address the impact of heavy metals on the ecosystem and human health. Among the 32 heavy metals, eight belong to the group of essential ones: cobalt, copper, iron, manganese, molybdenum, nickel, selenium, and zinc. They were necessary in physiological amounts for the evolution of flora and fauna, including humans on earth, and are still ne [...]

by Marina Moguilevitch  and Tracey Straker

Received: 05 July 2020;  Published: 12 November 2020;  doi: 10.21926/obm.transplant.2004123

Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson’s disease is based on the combination of specific clinical findings, laboratory and genetic testing. There are different modalities of treatment available for this condition. Liv [...]

by Christine M. Bojanowski  , Ian Britton  and Kamyar Afshar

Received: 18 April 2018;  Published: 16 July 2018;  doi: 10.21926/obm.transplant.1803015

Here we present a case of a lung transplant recipient with alpha 1-antitrypsin deficiency as well as conducted a retrospective review of the United Network for Organ Sharing (UNOS) database from 1990 – 2016 specifically grouping patients with alpha-1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD).

by Anjali Singh  , Kashish Ujla  and Smriti Shrivastava

Received: 25 January 2025;  Published: 19 June 2025;  doi: 10.21926/cr.2502004

Lignocelluloses are complex plant polysaccharides made of lignin, cellulose, and hemicellulose, and products made from these components find immense market potential. They can be effectively valorized to products related to bioenergy, bioplastics, food and nutrition, medication delivery systems, and other elements. Significant sources of lignocellulosic biomass include sugarcane bagasse, corn cob, rice straw, potato haulms, cocoa pods, etc. Enzyme-based valorization processes find immense potential, as they are eco [...]

by Raffaele Pezzilli

Received: 07 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.hg.1902017

Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic necrosis is a new entity of complications of acute pancreatitis. It is defined as a mature, encapsulated collection of pancreatic and/or peripancreatic necrosis which has developed a well-defined inflammatory wall. WON us [...]

by Richard Cheng  and Jon Kobashigawa

Received: 23 January 2019;  Published: 09 April 2019;  doi: 10.21926/obm.transplant.1902061

Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generation drug-eluting stents has been associated with high and unacceptable restenosis rates. However, second-generation drug-eluting stents are associated with favorable stent and lesion patency. Stent and lesion patency now [...]

by Shibani Kanungo  , Samantha A. Vergano  , Thomas Clark  , Rami Madani  , Melissa Schott  , Kira Couch  , Rubie Villela  and Natalie White

Received: 07 September 2023;  Published: 12 January 2024;  doi: 10.21926/obm.genet.2401210

Krabbe disease (KD), a severe neurodegenerative disorder, has been controversial in the space of newborn screening (NBS) in the United States. Families continue to advocate for the addition of KD to the Recommended Uniform Screening Panel (RUSP) after being declined for the second time in February 2023. Even with significant progress in KD screening tests, uncertainty about the phenotypic presentations, and effectiveness of hematopoietic stem cell transplant (HSCT) seems to have impeded the addition of this conditi [...]

by Beom-Jin Lee  , Manal Hadi Ghaffoori Kanaan  , Sura Saad Abdullah  and Abdolmajid Ghasemian

Received: 04 July 2025;  Published: 18 August 2025;  doi: 10.21926/obm.genet.2503308

Cancer continues to be one of the leading causes of global death, and conventional therapies have limited efficacy because of their toxicity, drug resistance, and off-target effects. Plant-derived nanoparticles (PDNPs) have emerged as suitable alternatives as they have biocompatibility, biodegradability, and multifunctional therapy. In this review, we discussed the recent advancements in PDNPs for cancer therapy, including the green synthesis of PDNPs using phytochemical (flavonoids, terpenoids) reducing and cappin [...]

by Laura Alonso Canal  , María José Quiles Blanco  , David Jiménez Leiva  and María José González Iglesias

Received: 26 June 2019;  Published: 30 September 2019;  doi: 10.21926/obm.hg.1903037

Alopecia areata is an autoimmune disease of unknown origin. It has been proposed that it is a multifactorial disease with genetic, immunological, infectious, circulatory, and psychogenic factors being involved in its etiopathogenesis. Its association with other autoimmune diseases is frequent. The infection of Helicobacter pylori has been linked to multiple immuno-mediated extradigestive conditions including alopecia areata. There is scientific evidence of the usefulness of naltrexone in low doses (an opioid antago [...]

by Lara T. C. Mota  , Igor M. Figueredo  , F. Murilo T. Luna  , Rodrigo S. Vieira  , Célio L. Cavalcante Jr.  and M. Alexsandra S. Rios

Received: 26 September 2022;  Published: 22 December 2022;  doi: 10.21926/jept.2204042

In this study, the oxidative stability of the cottonseed oil biodiesel (CB) and soybean oil biodiesel (SB) was investigated by two methodologies, Rancimat and Differential Scanning Calorimetry (DSC), using samples fresh and aged (mid-term storage condition (100 days)). The biodiesel samples were synthesized by transesterification and characterized by specific mass, kinematic viscosity, acidity value, ester content, viscosity index, and peroxide value. The activation energy (Ea), Arrhenius pre-exponential factor (Z) [...]

by Zoi Portokalidou  , Anna Huysse-Gaytandjieva  and Madelon L. Peters

Received: 09 January 2022;  Published: 12 July 2022;  doi: 10.21926/obm.icm.2203027

Hashimoto thyroiditis (HT) is an autoimmune disease affecting mainly middle-aged women. Hormonal replacement is the most common therapy; however, it tackles only the functionality of the thyroid and not the autoimmunity components. Thus, patients experience persistent somatic and psychological symptoms, thereby affecting their quality of life. The cause of HT remains uncertain. Primary evidence suggests that adverse experiences in childhood are associated with autoimmune disease manifestation in adulthood; therefor [...]

by Hawi Jihad Kedir  , Birhanu Zeleke Tilinti  and Kasahun Tsegaye Mekonnen

Received: 07 January 2025;  Published: 02 June 2025;  doi: 10.21926/rpn.2502013

Tomato (Solanum lycopersicum L.) is the largest vegetable crop produced and consumed in the world. Tomatoes are a top source of Vitamin A and C, contain more dietary fibre, beta-carotene, iron, lycopene, magnesium, niacin, potassium, phosphorus, riboflavin, and thiamine. Tomatoes have a limited shelf life in ambient conditions and are highly perishable. It creates glut during the production season and becomes scanty during the off-season. Short shelf life, coupled with inadequate processing facilities results in he [...]

by Anita Modi  and Sherif Beniameen Mossad

Received: 07 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.transplant.1903085

Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of malignancy has led to markedly reduced tumor burden and improved patient survival, sparking curiosity about their potential role in the treatment of other chronic inflammatory states, including infectious diseases. While [...]

by Robin Junker

Received: 24 November 2022;  Published: 01 February 2023;  doi: 10.21926/obm.icm.2301011

Stress in teaching leads to many teachers suffering from burnout or leaving the profession. Therefore, it is important to identify specific correlates of teacher stress. The role of student age and social-emotional competence in teacher stress emergence is still unclear To further clarify this relationship, 284 teachers were surveyed using a questionnaire that measured teacher stress, student year grade, and student social-emotional competence. Results show a strong negative relationship between grade level and tea [...]

by Christin Deal  , Kara Coffey  and Hey Chong

Received: 02 June 2023;  Published: 04 August 2023;  doi: 10.21926/obm.genet.2303190

Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) has been successfully implemented in all 50 United States and Puerto Rico from 2008-2018. This life-saving screening tool has drastically improved overall survival of babies diagnosed with SCID from 74% to 96%. TREC is a stable, circular DNA molecule that is produced during the process of T-cell receptor (TCR) rearrangement and is the target of the quantitative PCR screen on Guthrie cards. Low TRECs are a marker of low naive T cell numbers. This ne [...]

by Dean M. Cordingley  and Stephen M. Cornish

Received: 29 April 2022;  Published: 07 July 2022;  doi: 10.21926/obm.icm.2203025

Sarcopenia is the age-related loss of muscle mass and strength which is associated with the loss of physical performance, lower quality of life, and other negative health outcomes. Resistance training (RT) is a recognized method to increase muscle strength and mass, however some older adults may be limited in their ability to perform RT with traditionally recommended higher-loads. Occluding blood flow to a limb, commonly referred to as muscle blood flow restriction (MBFR), has been investigated as an adjunct to RT [...]

by Jill Gualdoni  , Jeff Ritzenthaler  , Ibrahim Elkhawas  , Gerene Bauldoff  , David Nunley  and Jesse Roman

Received: 29 November 2018;  Published: 20 February 2019;  doi: 10.21926/obm.transplant.1901051

Background: Gastroesophageal reflux disease has been associated with the development of chronic lung allograft dysfunction following lung transplantation. While the mechanisms are unclear, it is postulated that microaspiration of gastrointestinal material (GIM) leads to inflammation and airway remodeling that culminates in obliterative bronchiolitis. As the expression of the matrix glycoprotein fibronectin has been shown to be an early marker of this fibroproliferative process, its induction could suggest a causal [...]

by Bradley Jorgensen

Received: 24 October 2022;  Published: 18 January 2023;  doi: 10.21926/aeer.2301009

The Contingent Valuation (CV) Method, like other stated preference techniques, seeks to measure economic preferences for public goods. Throughout the development and application of this non-market procedure, the accuracy of the measured preferences has been front-and-centre among practitioners and potential users. The most important issue of debate has been the extent to which the method can reliably measure economic preferences. In this article, a new methodology is described that enables multiple indicators of la [...]

by Assaf Assis  , Lena Sapozhnikov  , Sandra Camargo  and Eduardo Mitrani

Received: 07 May 2019;  Published: 14 August 2019;  doi: 10.21926/obm.transplant.1903078

Background: Cell encapsulation technology is most likely the ultimate solution for cell therapy based clinical approaches. A key issue when developing a functional encapsulated construct is to consider not only the nature of the capsule but also how the cells should be incorporated into the capsule in order to minimally compromise their function. Methods: We have developed a tissue engineering approach, composed of decellularized micro scaffolds and various types of cells in which fully functional "Engineered Micro [...]

by Nathir A. F. Al-Rawashdeh

Received: 01 July 2025;  Published: 03 August 2025;  doi: 10.21926/cr.2503007

by Srinivasan Periasamy  , Se-Ping Chien  , Chen Hsu  , Dur-Zong Hsu  and Ming-Yie Liu

Received: 10 March 2020;  Published: 18 May 2020;  doi: 10.21926/obm.hg.2002047

Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hyperglycemia and diabetes. We studied the role of metformin in reversing sleep deprivation-induced hyperglycemia and pancreatic and liver dysfunction in mice. Mice were kept in cages and fed water and food ad libitum. Mice wer [...]

by Gerald Jandl  , Rainer Horn  , Richard Schroeder  , Kai-Uwe Eckhardt  and Peter Leinweber

Received: 23 November 2022;  Published: 22 March 2023;  doi: 10.21926/jept.2301012

The increasing number of biogas plants with various digested organic materials and output of digestates calls for more detailed investigations of their suitability as soil amendments. In a trial in Northern Germany two replicate plots each were treated with fresh or prolonged fermented digestate to investigate the influence of digestates on the composition of soil organic matter (SOM). The relative proportions of relevant SOM compound classes were determined by pyrolysis-field ionization mass spectrometry (Py-FIMS) [...]

by Tülin Avcı Hansu

Received: 25 December 2023;  Published: 15 May 2024;  doi: 10.21926/cr.2402005

In this study, by producing bifunctional material, hydrolysis, and supercapacitor applications were investigated. The carbon nanotube-supported Pt catalyst was prepared using the sodium borohydride (NaBH4) reduction. Surface characterization of the synthesized Pt/CNT catalyst was performed using scanning electron microscopy-energy dıstrıbutıon X-ray spectrometer (SEM-EDX), X-ray diffraction (XRD), and transmission electron microscopy (TEM). Hydrolysis experiments were performed after deciding on the appropriate ato [...]

by Areen Omary  and Tameka Chambers

Received: 17 August 2021;  Published: 22 December 2021;  doi: 10.21926/obm.geriatr.2104185

The current study aimed to examine if sex can significantly predict risk for lifetime major depressive episodes among adults aged 65 and older with and without adjustment for covariate variables of race, education, marital status, health, and poverty. Secondary data was obtained from the National Survey on Drug Use and Health public-use data file to achieve study goals. The study participants were males and females aged 65 years or older. The unweighted sample included 3,969 adults aged 65 years or older, represent [...]

by Rohan R. Ravindranath  , Brian De La Franier  , Issaka Yougbare  , Jason E. Fish  and Michael Thompson

Received: 25 January 2020;  Published: 27 March 2020;  doi: 10.21926/rpm.2001008

Coronary artery disease is one of the major causes of morbidity and mortality worldwide. Coronary stents, tube-shaped medical implants that are placed in narrowed coronary arteries, have been used successfully in the management of this condition. However, re-narrowing (i.e. restenosis) of the artery can occur which is instigated by an immune response towards the implanted ‘foreign’ material. A new approach to prevent restenosis and reduce the stent-induced immune response has been proposed previously, which involve [...]

by Grace Douglas  , Andrew S Day  and Stephanie C Brown

Received: 23 August 2024;  Published: 13 December 2024;  doi: 10.21926/rpn.2404020

Dietary and nutritional interventions have been shown to have roles in managing active Crohn disease (CD), with exclusive enteral nutrition (EEN) being recommended as the preferred initial treatment in children following diagnosis. In recent years, other nutritional interventions such as the Crohn's disease exclusion diet (CDED) have been considered and evaluated for induction therapy. To date, the long-term benefits of CDED have not been established. This report highlights the outcomes of the prolonged use of CDED [...]

by Fathi M. Layas  , Vail Karakale  and Ramadan E. Suleiman

Received: 28 April 2023;  Published: 27 July 2023;  doi: 10.21926/rpm.2303029

In recent years, regional wars and terror activities have caused blast-loading effects on reinforced concrete buildings, resulting in catastrophic human and material damage. When a building is exposed to a blast load, a very high air pressure affects the building within a very short duration. To decide on the reconstruction or retrofit of a building exposed to blast loading, the behavior of the building under blast loading should be investigated. In this paper a case study of a RC building exposed to blast loading [...]

by Ousman Bajinka  , Mamtuti Panneh  , Sang Mendy  , Amadou Barrow  , Haddy Bah  , Lamarana Jallow  , Jarry Jallow  , Kaddy Drammeh  , Kaddijatou Kah  , Oulimatou Lateef  , Mariama A Bah  , Isatou K Sillah  , Fatoumata Bah  , Nyima Ceesay  , Mariama Jaiteh  and Yurong Tan

Received: 31 August 2024;  Published: 08 April 2025;  doi: 10.21926/rpn.2502006

The adverse effects of maternal passive smoking during pregnancy on offspring health remain understudied in sub-Saharan Africa, particularly in The Gambia, where smoke-free regulations are limited. To determine the prevalence of maternal passive smoking (MPS) during pregnancy and investigate its associations with adverse pregnancy outcomes and offspring health complications in The Gambia. A cross-sectional study was conducted in February 2023 among 401 mothers with children under 5 years in urban and rural regions [...]