Wind-Stress Variations from Deep to Shallow Water during Hurricanes for Air-Sea-Land Interaction Applications
Abstract
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Wind-Stress Variations from Deep to Shallow Water during Hurricanes for Air-Sea-Land Interaction Applicationsby
Abstract
In September 2020 Hurricane Sally impacted two National Data Buoy Center (www.ndbc.noaa.gov) buoys near its track: 42040 in the deep water and 42012 in the shallow. Using pertinent air-sea interaction formulas from the literature, analyses of these buoy data indicate that, under fully rough airflow and wind sea conditions, U* = a Hs2 /Tp3 + b, here U* is the friction velocity, Hs is the significant wave height, and Tp is the peak wave period. It is found that a = 28 and b = 0.12 for the deep water environment, a = [...] 1391 11438 |
Head Circumference as An Indicator of Nutritional Status in Critically Ill Children under 2 Years of AgeAbstract
Many clinical, biochemical, and anthropometric factors have been used to determine the nutritional status of critically ill children. One of the most commonly used anthropometric measurements in children is the head circumference. It is used to assess their development, and in some instances, can be an indicator of chronic malnutrition. We aim to study the association between head circumference and the nutritional status of critically ill children under 2 years old. We retrospectively obtained the head circumferenc [...] 1391 13518 |
Who Believes in Fake News: A Study on the Relationship between Affective Temperament, Cyberchondria and Problematic Use of the Internet during the COVID-19 Pandemicby
Abstract
The COVID-19 outbreak has been associated with various psychological problems, such as Cyberchondria, constant research for information online, to obtain health-related information. This was associated with problematic social media use and various psychological problems. This study aimed to measure the characteristics of fear and anxiety of COVID-19, the generalized approach to online searching and the use of the Internet about the perception of health, during a pandemic. The online survey was disseminated from Apr [...] 1391 9467 |
Kinetics and Thermodynamics of the Pyrolysis of Waste Polystyrene over Natural Clayby
Abstract
Due to the massive increase in polymer manufacture, there has been a remarkable increase in plastic waste. With fewer landfills being used to dump plastic waste each year, it is becoming increasingly important to use effective recycling methods for plastic waste decomposition. In the present work, waste polystyrene was degraded in the presence of natural clay (K0.02, Ca0.15 [Mg0.25, Al0.69, Fe0.06], [Si2.0, Al0.6] O6.8 (O10) nH2O). The waste polymer was pyrolyzed at different heating rates i.e., 5, 10, 15 and 20 [...] 1390 10561 |
Synthesis of a Solid Base Catalyst Formed from Zinc(II) Acetylacetonate and Consisting of MgO Modified with ZnOAbstract
Solid base catalysts consisting of MgO modified with 10 mol% ZnO (ZnO/MgO) were prepared by depositing zinc(II) acetylacetonate (Zn(acac)2) in polar and nonpolar organic solvents on the surface of MgO and Mg(OH)2. The process was followed by thermal decomposition in air at 773 K over a period of 3 h. The activity of MgO modified with Zn(acac)2 for base-catalyzed retroaldol reaction (the decomposition of diacetone alcohol (4-hydroxy-4-methyl-2-pentanone) to acetone) at 299 K was higher than the activity of unmodifie [...] 1389 9780 |
Holy be the Lay: A Way to Mindfulness Through Christian PoetryAbstract
Mindfulness practices have exploded in popularity in public awareness and in therapeutic applications. While mindfulness in a therapeutic context is presented as a secular practice, its primarily Buddhist heritage may make some Christian clients wary of engaging. Research indicates that both reflection (co-creation) on poetry and creation of poetry can be therapeutic, and that both Buddhist and secular/therapeutic mindfulness texts use poetry to convey meaning through key themes of nature, change/impermanence, stag [...] 1389 9899 |
Bioactive Properties of Sorghum-based Beverages from Whole or Refined GrainsAbstract
Sorghum-based beverages were developed and the effects of decortication on nutritional composition and biofunctional properties after a simulated gastrointestinal digestion were analyzed. For that, white sorghum flours from whole (WS) and decorticated (DS) grains were obtained and used to prepare sorghum beverages. They were analyzed regarding chemical composition, minerals, and phenolic acid contents. Moreover, the bioaccessibility of phenolics, proteins, and the potential bioactivity (ABTS+ scavenging, ACE-I inhi [...] 1389 8790 |
Influence of Teachers’ Secondary Traumatic Symptoms on Their Burnout, Compassion Fatigue, and Intentions to Resign in Low Socioeconomic Status SchoolsAbstract
The current study explored the adverse outcomes of secondary traumatic symptoms experienced by secondary school teachers on their compassion fatigue, burnout, sense of satisfaction, and intention to resign from the teaching profession in low SES schools in the United States context. The study was inspired by Ludick and Figley’s Compassion Fatigue and Resilience model and Figley’s work on Compassion Fatigue. A non-experimental design was employed, and data were gathered from a random sample of 131 teache [...] 1387 8615 |
Building New Nuclear in Finland: Crises Challenging Core Beliefs around Nuclear EnergyAbstract
This paper examines the building of a new nuclear plant as a greenfield operation in Pyhäjoki, Finland. A newly-founded energy company, Fennovoima, was granted a license by the Finnish parliament to build a new power plant in 2010. In the years following this Decision in Principle the project faced several obstacles. Through interviews with key actors, this paper identifies the interests and core beliefs associated with building the plant. It posits that, in Finland, the underlying ideas and values surrounding nucl [...] 1387 12886 |
Examining the Carbon Management Strategies of Diebold Nixdorfby
Abstract
Carbon management is imperative to curb global temperature increases and mitigating climate change impacts. This report explores the carbon management strategies employed by Diebold Nixdorf, a multinational financial and retail technology company. As of 2021, the company has not established specific reduction targets and has not committed to achieving net zero emissions. The company employs diverse carbon reduction strategies, such as carbon offsetting, solar energy, and fleet improvements, with notable projects li [...] 1386 8401 |
Gene Therapy Strategies for Muscular Dystrophies: Current Insights and Future DirectionsAbstract
Gene therapy, a groundbreaking method for addressing genetic mutations, includes strategies such as gene repair, replacement, inactivation, or the introduction of therapeutic genes, circumventing traditional surgical or pharmacological approaches. Delivery through viral or non-viral vectors presents trade-offs in efficiency and immune response. Recent gene-editing technologies like ZFNs, TALENs, and CRISPR facilitate precise genome modifications by inducing targeted double-strand breaks, with CRISPR/Cas9 recognized [...] 1385 20005 |
Mechanisms of Laser Acupuncture – Hypotheses and EvidenceAbstract
Laser acupuncture, a rising complementary therapy, applies a low-intensity laser to acupuncture points, yet its underlying mechanisms remain unclear. Proposed hypotheses include modulation of cellular signaling, tissue repair, and immune modulation. Laser acupuncture may stimulate energy flow, neurotransmitter release, cellular changes, immune regulation, and neuroendocrine activity. Additionally, the biophoton theory suggests an involvement of ultra-weak photon radiation from cells. Litscher et al. explore these m [...] 1384 8909 |
Optical, Charge Transport, Thermal, Magnetic, Plasmonic, and Quantum Mechanical Properties of Iridiumby
Abstract
Spectrophotometry has been widely used to retrieve the dielectric function of a bulk iridium sample using an extended version of the Drude–Lorentz model. The parameters of the model are optimized using a spectral-projected-gradient-method-assisted acceptance-probability-controlled simulated annealing approach. Furthermore, optimized values of Drude parameters corresponding to the optical response of electrons and holes (scattering frequency of electrons, the ratio between scattering frequencies of holes and electro [...] 1383 9126 |
Phenotypic Characterization of Advanced Breeding Lines of Rice (Oryza sativa L.) for Drought and Low Phosphorus Stress Toleranceby
Abstract
Drought and phosphorus (P) deficiency stress are two significant natural abiotic stresses restricting rice growth and yield worldwide. Developing rice varieties tolerant to drought and low P stress is crucial for sustainable agricultural production. To address these issues, two separate experiments were conducted using selected advanced rice breeding lines to study the impact of drought and low P stress on yield-attributing traits. The first experiment evaluated the drought stress tolerance of five advanced lines ( [...] 1382 8597 |
Cortical Activity and Rhythmic Patterns in Mouse Models of Aging and Alzheimer’s DiseaseAbstract
Aging and Alzheimer’s disease (AD) have been reported to induce changes in the cerebral cortex circuits. The present review aims to study these alterations by reviewing emergent cortical activity with a focus on the rhythmic patterns. The rationale for this approach was two-fold: (i) emergent rhythmic activity integrates cellular and network properties of these underlying circuits; and (ii) alterations in rhythmic patterns reflect the functional impact of changes on the network induced by the pathophysiology of the [...] 1382 10541 |
The Effect of Rake Angle and Cutting Edge Radius on the Orthogonal Cutting Process of Ti6Al4V AlloyAbstract
This paper investigates the effect of rake angle, α, cutting edge radius, r, and feed rate, f, on the cutting force and cutting zone temperature during orthogonal dry cutting of Ti6Al4V. A numerical model representative of the 2D orthogonal cutting process is developed using ABAQUS/Explicit software. Johnson-Cook, (JC) constitutive material model is used to describe material plasticity. JC damage model and energy-based fracture criterion are used to describe damage initiation and evolution. Using Minitab-19 softwar [...] 1382 7891 |
Whole Genome Sequencing in Era of Newborn ScreeningAbstract
After the completion of the human genome project, there have been many advances in the field of genetics. With next generation sequencing, patients can undergo genomic analysis through whole exome or whole genome testing. These comprehensive tests can shorten the diagnostic odyssey and guide medical management and thereby potentially reduce mortality and morbidity. To date, parents and physicians have reported positive perceptions of using these genomic testing even when a diagnosis is not made. Remaining challenge [...] 1381 10303 |
The COVID-19 Geropsychiatry Rounds: A Curriculum for Healthcare ProvidersAbstract
Older adults’ mental health needs significantly increased during the COVID-19 pandemic. Geriatric psychiatry is an area of extreme workforce shortage globally. A novel curriculum was developed to educate healthcare providers on COVID-19-related geriatric and geropsychiatry topics. Monthly lectures were presented from November 2020 to June 2021. Evaluations were collected after each lecture via an anonymous survey. Overall lecture quality and relevance for the participants’ clinical practices were rated on a 1-3 Lik [...] 1381 8817 |
The Impact of Wellbeing Interventions on the Anxiety Levels of Children Attending Low-Income Schools: A Systematic Literature ReviewAbstract
This systematic review examined the impact of wellbeing interventions on the anxiety levels of children attending low-income schools. Studies, published between January 2000 and April 2022, were included if they had samples of school aged children attending low-income schools who were given a universal school-based wellbeing intervention. Ten databases were searched systematically to identify 542 records. After title and abstract screening, 43 records remained for full text screening, and of these studies, 10 met i [...] 1381 7010 |
“Seeing Myself Through Someone Else’s Eyes”: Embodying the Perfect Nurturer in Compassion Focused TherapyAbstract
Compassion-focused chairwork has become a recent focus of empirical investigation. This study extended this area of research by exploring how participants with depression experienced the ‘compassionate other’ imagery exercise enacted via chairwork methods. Eight individuals from primary care NHS mental health services were interviewed about their experience of the practice. The resultant data were analysed using interpretive phenomenological analysis (IPA). Three group experiential themes were identified: care that [...] 1381 9212 |
Spinal Muscular Atrophy: An OverviewAbstract
Spinal muscular atrophy, a leading cause of infant death, is a neurodegenerative disease classified categorically based on age of onset and achieved motor function. The standard method of diagnosis is through molecular genetic testing, ideally through the newborn screen to facilitate early diagnosis and treatment. There are 4 types of spinal muscular atrophy, each with varying degrees of symptoms based on the number of survival motor neurons. Current treatment options include gene therapy and supportive care. Futur [...] 1380 10611 |
A Service Based Evaluation of Compassion Focused Group Therapy Within a Community Mental Health Team SettingAbstract
The current paper explores the impact of Compassion Focused Therapy (CFT) when delivered in a group setting to people with a range of diagnoses presenting to a Community Mental Health Team. In total five groups of 14 to 18 sessions were run with an average of five participants completing each group. A range of self-report measures examining global psychological distress, self-criticism, depression, anxiety and stress, emotion regulation, social comparison, shame and compassionate attributes and skills were administ [...] 1379 8695 |
Influence of Recycled Concrete Aggregate Type on Rheological Behaviour of Mixtures Proportioned Using the Equivalent Volume Methodby
Abstract
The ever-growing urgency to combat climate change has led the civil construction industry to develop and adopt sustainable construction materials and methods. The so-called recycled concrete aggregate (RCA) emerges as an alternative to decrease the carbon footprint of new concrete construction, the disposal of waste concrete, and the use of non-renewable natural resources such as cement and aggregates. RCA can be produced from crushing waste concrete; yet challenges remain when using RCA in concrete especially its [...] 1378 9150 |
Nature and City Sounds Influence Physiological and Psychological Markers in College StudentsAbstract
Worldwide, human population growth has led to a higher demand for urbanization. While this development is in accordance with our gregarious lifestyles, our availability and contact with nature has consequentially been minimized. The goal of this study was to evaluate whether sounds from nature versus urban environments affect vital signs (i.e., heart rate and respiration rate) and mood states of female college students. Emotional states were assessed using the Positive and Negative Affect Schedule (PANAS) questionn [...] 1377 7974 |
The Association between Uric Acid Level and Ischemic Strokeby
Abstract
Stroke is the second and third leading cause of death and disability, respectively, all over the world. It seriously affects patients' lives and brings huge burdens to their families. Ischemic stroke accounts for most of the stroke cases. In the absence of any effective treatment, prevention measures through controlling the risk factors for ischemic stroke become crucial. While uric acid has been reported as an essential risk factor for ischemic stroke, researchers hold inconsistent views regarding the specific ass [...] 1377 8373 |
Misinterpretation or Underestimation of the Appearance, Location, or Size of Non-bleeding Visible Vessels (Forrest Class IIa) as a Cause of Hemostasis FailureAbstract
(1) Background: Endoscopy has become the primary diagnostic and treatment technique for non-variceal upper gastrointestinal bleeding. Despite advancements in therapeutic methods and instrumentation, endoscopic hemostatic failure occurs in 10% of patients. This study aimed to analyze endoscopic findings in patients with failed hemostasis and to elucidate strategies for endoscopists and gastroenterologists to facilitate improved treatment outcomes.
(2) Methods: A total of 128 patients received hemostatic treatment fo [...] 1375 9157 |
Assessment of Agro Allied Chemical Pollution on Surface Water Quality of River Lamurde and Mayo-Gwoi, Jalingo, Taraba State, NigeriaAbstract
Water bodies have been severely degraded in recent years due to the indiscriminate use of agro-allied chemicals. The study assesses the agro-allied chemical pollution on the surface water quality in River Lamurde and Mayo Gwoi. Water samples were collected from twenty-one (21) sample locations along the River Lamurde and Mayo-Gwoi to determine the seasonal variation during the wet and dry seasons through field determination of water quality and laboratory-based analysis at Taraba State Rural Water Supply and Sanita [...] 1374 10317 |
Molecular Marker Applications in the Selection of Elite Genotypes for Plant Stress Tolerance and Genetic FidelityAbstract
Molecular markers play a crucial role in accelerating crop production for sustainable agriculture by identifying resistant traits and enhancing genetic diversity. In this review, we examine the impact of the molecular markers on advancing our understanding of stress tolerance mechanisms in plants, addressing the pressing imperative to bolster global food production to meet the escalating demands of the growing population. Additionally, the application of molecular markers to evaluate the genetic accuracy of plants [...] 1374 9868 |
Differences in Blame-Like and Forgiveness-Like Judgments between Young People, Healthy Older People, and Older People with DementiaAbstract
The objective of the present experimental study was to compare how young people, healthy older people, and older people with dementia cognitively integrated three factors (Intention, Consequence, and Apology) when making blame-like judgments (prosecution and revenge) and forgiveness-like judgments (resentment and reconciliation). Thirty-four young people (Mage = 22.12, SD = 3.44), 22 healthy older people (Mage = 71.82, SD = 8.69), and 18 older people with dementia (Mage = 75, SD = 10.06) participated in the study. [...] 1374 7148 |
Artificial Neural Networks and Gradient Boosted Machines Used for Regression to Evaluate Gasification Processes: A ReviewAbstract
Waste-to-Energy technologies have the potential to dramatically improve both the natural and human environment. One type of waste-to-energy technology that has been successful is gasification. There are numerous types of gasification processes and in order to drive understanding and the optimization of these systems, traditional approaches like computational fluid dynamics software have been utilized to model these systems. The modern advent of machine learning models has allowed for accurate and computationally ef [...] 1374 10236 |
Antibody-Mediated Rejection in Kidney Transplantation: Immunopathogenesis, Innate–Adaptive Crosstalk, and Therapeutic AdvancesAbstract
Antibody-mediated rejection (ABMR) remains a major barrier to long-term graft survival in kidney transplantation. Defined by the presence of donor-specific antibodies (DSAs) and characteristic histological changes, such as C4d deposition in peritubular capillaries, ABMR can present acutely, chronically, or subclinically, often manifesting as graft dysfunction. Recent advances in genomic profiling and diagnostic assays have improved our understanding of its pathophysiology, yet therapeutic strategies remain limited. [...] 1374 15030 |
Contributing Factors to Forest Loss in Conterminous U.S. for the 1990s and 2000sby
Abstract
While numerous studies have considered forest loss factors at local scales, there is a gap of comparative quantitative regional modeling at the U.S. national level. Here, we investigated statistical relationships between gross forest cover loss (GFCL) and numerous socioeconomic, biophysical and ownership variables between two decades, the 1990s and the 2000s. A spatial error model was employed to compensate for spatial autocorrelation effects. Models from the 2000s had stronger explanatory power than the 1990s mode [...] 1372 8809 |
Appropriate Vancomycin Use and Incidence of Vancomycin-Resistant Enterococci in Liver Transplant RecipientsAbstract
Liver transplant recipients (LTRs) are at risk for vancomycin-resistant Enterococcus (VRE) infections which can lead to significant morbidity or mortality. Antibiotic exposure, including vancomycin, is associated with greater risk of VRE infection. This study aimed to assess the appropriateness of vancomycin use and rates of VRE infection in this population. We performed a retrospective cohort study of 327 patients who underwent liver transplantation at our center from January 1, 2012 to June 30, 2017. Sixty (18.3% [...] 1372 8422 |
Rare Causes of Acute Pancreatitis: Drugs, Eosinophilia, and Autoimmunityby
Abstract
Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP).
Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February 2019 and those related to new drugs responsible for acute pancreatitis.
Results: we found about thirty reports of eosinophilic pancreatitis associated or not with hypereosinophilia and gastro-intestinal manifestations. [...] 1369 8835 |
Employee Support During COVID-19 Using Compassionate Mind TrainingAbstract
An individual’s wellbeing at work is now recognised as key, particularly for those in challenging environment’s such as health and social care. Focusing on the cultivation of (mindful) compassion has been shown to be an effective way of improving mental health. This service evaluation focused on a pilot drop-in group for council and NHS staff, informed by Compassionate Mind Training. It was facilitated during the COVID-19 pandemic, between April – August 2020. The group was evaluated by recording the number and cha [...] 1369 13650 |
Physicochemical Characterization and Mineral Composition of “UENF SD 08”: A Super-Sweet Corn Hybridby
Abstract
Sweet Corn (Zea mays L.) is possibly the most important commercial cereal originating in the Americas. Mutant genes are responsible for sweetness. The purpose of this study was to evaluate the physicochemical and mineral composition of the “UENF SD 08” cultivar, super-sweet corn developed at Darcy Ribeiro Northern Rio de Janeiro State University (UENF) and registered in the National Cultivar Register of the Ministry of Agriculture, Livestock, and Supply and to compare its content to commercial super-swe [...] 1369 8870 |
Restoration of Reservoir Caprock: Long-Term Wellbore Sealing and Abandonment through Zeolite Enhanced CementAbstract
Oil and gas wellbores that are drilled into the earth’s crust need to be plugged and abandoned, to restore the geological seals once they are no longer producing. The main aim of Plugging and abandonment (P&A) is to ensure that there is no leakage of hydrocarbons into the environment. Since offshore P&A is challenging due to subsurface temperature and pressure conditions, testing zeolite as an additive for improvement of cement properties is an intriguing research topic. This initial research aims to [...] 1368 9152 |
Strength Properties of Cellulosic Fibrous Mats Impregnated with Water Repellents Based on Reclaimed PolystyreneAbstract
Cellulosic fibrous mats were impregnated with various water-repellent formulations based on reclaimed polystyrene (5, 10, 15, and 20%), alkyd resin (5%), gum rosin (5%), and paraffin wax (0.5%). The mats were tested for their bursting strength and resistance to bending. They were also subjected to the ring crush test and short-span compression test. By increasing the concentration of total solid ingredients (5, 10, 15, 20, and 25.5%), the retention and grammage of the mats were increased, and all strength propertie [...] 1367 6363 |
Sleep Quality, Sleep Efficiency, and Perceived Stress after Synchronous Virtual Mindfulness Meditation Sessions for Higher Education StudentsAbstract
This study examined the effects of virtual mindfulness meditation programming on sleep efficiency using wearable tracking devices, as well as effects on sleep quality and perceived stress in higher education students. A one-group, pretest-posttest design with convenience sampling and rolling recruitment over a six-month period resulted in twenty-five participants who completed the study and were included in data analysis. Paired t-tests were used to determine statistical significance for sleep efficiency measured u [...] 1365 9385 |
The Origin of Natural Neurostimulation: A Narrative Review of Noninvasive Brain Stimulation TechniquesAbstract
This narrative review of the literature on noninvasive brain stimulation techniques observes four neurostimulation domains: light therapy, photobiomodulation, a group of techniques within transcranial electric current and magnetic field stimulations, low-frequency sound stimulations, including vibroacoustic therapy, and rhythmic auditory stimulation. The review aims to determine whether or not different brain stimulation approaches rely upon a similar physicochemical sequence of actions. The study identifies releva [...] 1365 12440 |
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Comparison Between How Narrative Therapy and Buddhist Mantra-Based Meditation Promote Mental HealingAbstract
This is a conceptual paper comparing how narrative therapy and Buddhist mantra-based meditation promote mental healing. Narrative therapy promotes mental healing by shifting families’ attention to their subjugated stories of strengths and personal agencies. Whilst Buddhist meditation has been integrated into psychotherapy developed in the West, the application is primarily the focus on breath as a way to help sufferers attain mindfulness. Mantra-based meditation uses the recitation of mantra as the focus inst [...] 1364 6952 |
Generalized Normal Distribution Optimization Algorithm for Economic Dispatch with Renewable Resources IntegrationAbstract
In an electric power system operation, the main goal of economic dispatch (ED) is to schedule the power outputs of committed generating units efficiently. This involves consideration of relevant system equality and inequality constraints to meet the required power demand at the lowest possible operational cost. This is a challenging optimization problem for power system operators that can be dealt with efficient meta-heuristic algorithms. This article uses a recent meta-heuristic approach named the generalized norm [...] 1363 9359 |
Effects of Coenzyme Q10 on H2O2-Induced Oxidative Stress of Human KeratinocytesAbstract
Keratinocytes are particularly vulnerable to oxidative stress due to their function as the primary natural protective barrier exposed to chemicals, rays, and pollution to stimulate the formation of free radicals in the body. Two factors of interest correlate with cellular senescence under oxidative stress. These include regulating antioxidant synthesis, which maintains free-radical homeostasis through the Nrf2 gene, and the prevention of telomere shortening, which involves the collaboration of human telomerase gene [...] 1362 8143 |
Gender-Dependent Effects of Endocrine Disrupting Chemicals on Retinoic Acid-Related Orphan Receptor Alpha [RORA] and Aromatase Genes on Human Progenitor NeuronsAbstract
Normally we encounter a myriad of chemicals in our daily lives. Endocrine disrupting chemicals [EDCs] are ubiquitous in our environment and upon bodily entry many be stored in adipose tissue and, in pregnant woman, can reach the developing fetal brain, disrupting normal fetal brain development. EDC-induced aberrant levels of sex hormones can alter sexual dimorphism [i.e. degree of feminization or masculinization; sex differences in brain and behavior] and may contribute to the differential susceptibility of males a [...] 1361 10014 |
Newborn Screening for Mucopolysaccharidosis Type I: Past, Present and FutureAbstract
Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder caused by a deficiency of the lysosomal hydrolase α-L-iduronidase. MPS I is characterized by a broad range of disease manifestations. This includes devastating neurocognitive and bone manifestations and a short life expectancy in severely affected MPS I patients. Neurocognitive manifestations are typically limited in more attenuated MPS I, but patients may still suffer from severe somatic and bone manifestations. Severe MPS I patients are primaril [...] 1361 9429 |
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