Assessment of Cytogenetic Abnormalities by FISH in Lymphocytes from a Victim Accidentally Exposed to Cobalt-60
Abstract
1620 8687
Assessment of Cytogenetic Abnormalities by FISH in Lymphocytes from a Victim Accidentally Exposed to Cobalt-60Abstract
Background: A radiation accident occurred on 14 June 2011 in an industrial facility in Bulgaria with a cobalt source (137 TBq) that was used to sterilize equipment. Five people received doses exceeding 1Gy, which led to the development of acute radiation syndrome. Biological dosimetry based on dicentric analysis was performed and the average acute whole-body doses estimated for the five patients ranged from 1.2 to 5.6 Gy. The purpose of this study was to evaluate induced chromosome aberrations in vivo four months af [...] 1620 8687 |
The Link(s) between Compassion and Healingby
Abstract
While it may seem intuitive to suggest that compassion aids in the healing process, there is actual evidence to support that compassion changes physiology, which in turns affects emotional and physical healing. The focus of this opinion paper is on the use of compassion between health care providers and patients based on the use of compassion in the mental health field. Not only do patients benefit from compassion, but health care providers may also benefit. Creating compassionate relationships with patients may [...] 1620 7241 |
Acknowlegement to Reviewers of OBM Integrative and Complementary Medicine in 2020Abstract
The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a [...] 1620 6634 |
Chasing Bodily-Self Ghost: Interoception-Aided Hypnosis in the Treatment for Depersonalization-A Case StudyAbstract
This paper aims to introduce a relatively novel approach for Hypnosis to treat Depersonalization-derealization Disorder (DPRD). Depersonalization is conceptualized as a disrupted interoceptive process disorder. Based on this conceptualization, Hypnotic intervention is tailored to counter the flawed process. It is exemplified by a case of a young man suffering from depersonalization disorder who couldn't bear looking at himself in the mirror. The hypnotic intervention used in this case is then explained by predictiv [...] 1619 14159 |
Measurements of Overwater Gust Factor from Near Surface to Beyond Common Hub Height: A Case Studyby
Abstract
In September 2020 Hurricane Sally affected the north central Gulf of Mexico. Making use of the anemometers data available at 4 oil rigs over the affected region, it is found that, when the atmospheric stability was near-neutral, the gust factor (G) decreases linearly with height from approximately 1.28 at 35m above the sea surface to 1.18 at 160 m. In other words, G decreases linearly at the rate around 8% per 100 m from the typical hub height to beyond common hub height. Based on the linear equation found in this [...] 1619 8304 |
A is for Autophagy and Alzheimer'sby
Abstract
Improved understanding of the underlying cellular dysfunction and resultant neuropathology of sporadic Alzheimer’s disease (AD) is needed to stem the anticipated public health crisis due to this increasingly common neurodegenerative disease. The four main risk factors for sporadic AD are age, female gender, genetic carriage of the APOE4 allele and type two diabetes mellitus (T2DM). Each of these four risk factors is associated with impaired and/or dysfunctional autophagy suggesting that perturbation of autophagy is [...] 1618 10230 |
Parting with the Concept of Alzheimer’s Disease in Seniumby
Abstract
The understanding of mental deterioration associated with old age has undergone several changes over the past two centuries, and has spurred major scientific debates. In the 19th century, this disorder was still considered an inevitable part of aging. The beginning of the 20th century offered a histological explanation for presenile dementia, and Alois Alzheimer was credited as the discoverer of a new disease that bears his name to date. In the last quarter of the 20th century, findings of Alois Alzheimer were appl [...] 1618 10524 |
Energy Storage and Installed Wind Capacity Requirements for the Substitution of Fossil Fuels in the Electricity Generation SectorAbstract
The impending adverse effects of Global Climate Change encourages the substitution of fossil fuels with non-carbon sources for electricity generation. However, while fossil fuel power plants may generate electric power at demand, the most abundant renewable energy sources-wind and solar-are intermittent or periodically variable. This necessitates the development of adequate energy storage at the utility/grid level. Using actual data for the hourly energy demand in the ERCOT electricity grid, this study examines the [...] 1618 11310 |
Narrative Review of Surgery for Myasthenia GravisAbstract
Myasthenia Gravis (MG) is a rare autoimmune disorder characterized by antibody mediated blockade of neuromuscular transmission. Up until the last decade, evidence suggesting benefit of thymectomy for myasthenia gravis has been based on non-randomized control studies. Our paper serves as an expert narrative review of new literature pertaining to surgical management of myasthenia gravis based on review of articles from PubMed and Cochrane database from date of inception through June 14, 2021. We used the MeSH search [...] 1617 12362 |
An Overview of Gratitude as a Mind-Body-Spirit Practice in Optimizing Health and Human FunctioningAbstract
This paper provides an overview of gratitude as a concept and as a mind-body-spirit practice, impacting health and human functioning throughout the lifespan, that can be integrated into daily life to great benefit at no cost. Current society is rife with increases in stress, anxiety, depression, lifestyle-related diseases, and social isolation. The practice of gratitude and its interrelated pro-social, health-enhancing, resilience-building effects suggest that promoting gratitude from childhood through adulthood ma [...] 1615 12430 |
The Use of Composite TiO2/Activated Carbon Fibers as a Photocatalyst in a Sequential Adsorption/Photocatalysis Process for the Elimination of CiprofloxacinAbstract
This work reports the performance of a sequential adsorption/photocatalysis process using activated carbon fibers with deposited TiO2 for the elimination of the antibiotic ciprofloxacin (CIP) in water. A commercial activated carbon fiber (ACF10) was selected as the support, and a TiO2 coating was synthesized using Metal Organic Chemical Vapor Deposition (MOCVD). Experiments were carried out using a photocatalytic reactor irradiated with monochromatic LEDs (365nm). Two different processes have been studied: adsorpti [...] 1614 11242 |
Sporadic and Hereditary Hemangioblastoma: The Role of Endothelial Cellsby
Abstract
Hemangioblastomas (HBs) are benign, highly vascularized tumors of the central nervous system. Approximately 75% of HBs are sporadic, while 25% are associated with von Hippel–Lindau (VHL) disease. HBs consist of two main components: a rich capillary network composed of vascular endothelia and pericytes, within large vacuolated stromal cells, which harbor the genetic defect. The mechanism by which the VHL gene product (pVHL) causes HB is not completely clear. Wild-type pVHL is involved in the response to hypoxia, tar [...] 1613 10822 |
Genetic, Social and Behavioral Risk Factors Associated with Alzheimer’s DiseaseAbstract
Alzheimer’s disease (AD) is a neurodegenerative condition which consists of stages of mental, memory, and cognitive decline. As it continues to stand as the sixth leading cause of death in the U.S., 44 million people worldwide are affected. The objective of this paper is to explore the risk factors for AD in an attempt to examine potential causes for the incidence of AD. We examined genetics, lifestyle, and pre-existing conditions as risk factors for AD. We found that there are various alleles, such as APP, P [...] 1613 10070 |
Lung Donor Selection and Management: An Updated Reviewby
Abstract
The shortage of donor lungs for transplantation is a major challenge, resulting in longer waitlist times for patients with a higher risk of waitlist mortality. It is crucial to continue promoting awareness about organ donation through legislation, public campaigns, and health care provider education. Only a small number of cadaveric donors meet the ideal criteria for lung donation, leaving many lungs unused. Donor lung utilization can be improved by carefully considering the extended-criteria donors, actively parti [...] 1613 17448 |
Cradle-to-Grave Life-Cycle Assessment of Cellulosic FiberboardAbstract
According to the United Nations Environment Programme (UNEP), the construction and operation of buildings accounted for nearly 38% of total global energy-related CO2 emissions in 2019. The construction sector has been striving to use more low-carbon footprint building products to mitigate climate change and enhance environmentally preferable purchasing. Over the last several decades, there has been substantial growth in engineered wood products for the construction industry. To assess these products used in constru [...] 1612 15520 |
Dietary Modulation of the Gut Microbiome in Inflammatory Bowel Diseaseby
Abstract
Inflammatory bowel disease (IBD), which includes ulcerative colitis, and Crohn’s disease, is a chronic relapsing-remitting inflammatory state of the gastrointestinal (GI) system. The cause of IBD is multifactorial, encompassing factors of genetics, environment, and the host immune system, initiating a complex interplay of maladaptive host immune responses and subsequent chronic inflammation. Aberrant host immune responses are at least in part due to changes in the commensal microbiome, which can in turn affect the [...] 1612 18694 |
Severe Hypercholesterolemia Associated with Steroid-Refractory Acute Liver GVHD: Unusual Complication of Allogeneic Hematopoietic Cell TransplantationAbstract
Severe hypercholesterolemia is an uncommon complication of allogenic hematopoietic cell transplantation (HCT). Treatment options for hypercholesterolemia due to liver graft-versus-host disease (GVHD) are limited because many antilipidemic medications are known to worsen hepatic functions. We report our experience on a case of a 38-year-old male with Philadelphia chromosome positive acute lymphoblastic leukemia presenting with steroid-refractory hepatic and lower gastrointestinal acute GVHD after matched sibling don [...] 1612 8336 |
Reaction Kinetics and Characterization of Slag-Based, High Strength, “Just-Add-Water” Type (One-Part) Alkali-Activated BindersAbstract
The influence of different levels of alkalinity, expressed using M2O-to-binder ratio (n) and activator SiO2-to-M2O ratio (Ms), (M being the Na+ or K+ cation) on the reaction kinetics, compressive strength development and the reaction product formation in slag-based systems activated using alkali powders are discussed. The fundamental idea is to better understand one-part, “just-add-water” type alkali activated binders that are easy-to-use than the systems that rely on liquid activators. The difference in the behavi [...] 1611 10995 |
Examination of Sustainable Water Management at Norway’s Major Hub Airport: The Case of Oslo Airport Gardermoenby
Abstract
The present study used a detailed qualitative longitudinal research approach to examine the trends of water consumption, wastewater volumes, and drainage water volumes in Oslo Airport Gardermoen, which is Norway’s major hub airport, between the years 2005 and 2020. An overall upward trend was observed in the water consumption at Oslo Airport Gardermoen, which was consistent with the growth in air traffic and aircraft movements during the study period. The annual water consumption per enplaned passenger was observed [...] 1610 13659 |
Wind Turbines for Decarbonization and Energy Transition of Buildings and Urban Areas: A Reviewby
Abstract
The recent tendencies of drastic variations of environmental conditions, inundations, severe winds, and gusts besides heavy and unexpected long-duration rains showed the world an image of what could happen if emissions and global warming are not adequately controlled. Implementing new energy solutions as fast as possible is essential to cope with climate change, one of the biggest threats to our survival. These alarming signs intensified research and development efforts to replace fossil-based activities with renew [...] 1610 20969 |
Addressing Uncertainty: The Emergence of the CRMS/CFSPID Diagnostic Category Following Newborn Screening for Cystic FibrosisAbstract
This article uses cystic fibrosis as a case study to examine how physicians and scientists have navigated uncertainty following newborn screening. Despite the many benefits of newborn screening, including earlier diagnosis, therapeutic intervention, and a reduced diagnostic odyssey, this public health approach also comes with challenges. For example, physicians began to document infants with indeterminate diagnoses - those with a positive screen who did not clearly fit into the cystic fibrosis or “normal” categorie [...] 1610 11853 |
ICM-OBM—There’s No Better Way to Publish Your Complementary Medical, Basic and Clinical Research ResultsAbstract
Integrative and Complementary Medicine (ICM-OBM) is an international peer-reviewed, open-access journal which covers all evidence-based scientific studies on integrative and complementary approaches to improving health and quality of life.
Integrative and complementary medicine comprises science-oriented “university” or academic medicine, but also experience-based medicine with all its complementary methods. It is not a special field in itself, but a signal for an all-encompassing medicine, open-minded about the p [...] 1609 10034 |
Self-Compassion-Based Interventions in Oncology: A Review of Current PracticesAbstract
Self-compassion consists of an attitude of self-support and self-benevolence. In the general population, increased self-compassion has been associated with well-being and decreased psychopathology. In oncology, higher self-compassion has also been linked with various benefits, such as lower emotional distress, fatigue, body-image disturbances, and sleep difficulties. Self-compassion also seems to foster treatment adherence. Various interventions based on self-compassion have recently been designed and tested in dif [...] 1609 12827 |
Identifying Novel Biomarkers of Frailty in Cirrhosis: Results from an Unbiased Proteomics Search from the Functional Assessment in Liver Transplantation (FrAILT) StudyAbstract
Background: Patients with cirrhosis suffer not only from commonly-diagnosed portal hypertensive complications such as ascites and hepatic encephalopathy but also from more insidious effects of chronic liver failure including muscle wasting, under-nutrition, and functional decline. These manifestations of physical frailty have been demonstrated to predict mortality in patients with cirrhosis independently of liver disease severity, but objective biomarkers associated with physical frailty in cirrhosis are needed. Th [...] 1608 10017 |
A Silent and Very Early Post-Liver Transplant Death by Candida ArteritisAbstract
Background: Graft site candidiasis is a serious complication after solid organ transplantation, often presenting as invasive arteritis leading to graft loss or even death.
Case Report: We report a case of anastomotic site candidiasis leading to arterial rupture and death at postoperative day 10 with no clinical warning signs. Preservation fluid cultures were negative and postoperative Doppler ultrasonography did not show vascular compromise. Postmortem examination revealed microscopic arterial wall abscesses harbou [...] 1608 9863 |
Kinetic Model for the Hydrolysis of Olive Oil by Lipase in Absence of EmulsifierAbstract
Lipase-catalyzed hydrolysis of olive oil has been studied in the absence of emulsifier. A simple mathematical model to predict the hydrolysis rate is derived from a proposed kinetic mechanism of the reaction. The hydrolytic reaction obeys Michaelis-Menten kinetics with a simultaneous second-order enzyme deactivation. The model predictions closely agree with the experimental results. 1606 9723 |
Influences of Household Processing Methods on Nutritional Composition, Anti-nutritional Factors and Antioxidant Activities of Foxtail Milletby
Abstract
The present investigation aims to study the influence of household processing methods, such as soaking, germination, and steam cooking, on nutritional composition (proximates, amino acids, minerals, and vitamins), antinutrient factors (phytochemicals: tannins, total phenols, phytic acid; enzyme inhibitors: trypsin and α-amylase inhibitors) and antioxidant properties of whole grains of foxtail millet. The contents of total ash (1.42%), fat (3.02 g/100 g), and mineral chromium (12.83 mg/100 g) were found to be [...] 1606 10431 |
Poly (Lactic Acid) (PLA)/Recycled Styrene Butadiene Rubber (rSBR) Compositesby
Abstract
Recycled styrene butadiene rubber (rSBR) from waste car tires was used as a filler in poly(lactic) acid (PLA) to modify its properties. The compounds were prepared via twin-screw extrusion and molded by injection with different rSBR contents (0 to 25% wt.). Additionally, recycled rubber particle size was controlled between 125 and 1000 μm to determine the effect of this parameter. From the samples produced, a series of morphological, physical and mechanical characterizations were performed. As expected, rSBR additi [...] 1605 10533 |
Determining the Band Alignment at the BiVO4|NiOOH Interface Using the Hybrid DFT TechniqueAbstract
It is important to understand the band offsets between semiconductors, which are crucial to determine the direction of electron transfer at the interfaces. Two methods are normally used to determine the direction from the first principles: alternating slabs put in contact (without empty spaces between them) and separate calculations for each material surface in the presence of vacuum spaces. The first method may introduce distortions due to insufficient epitaxial match, which may lead to bandgap changes, and the se [...] 1604 9867 |
Nb2O5: Percentage Effect of T/H Phase and Evaluation of Catalytic Activity, a Preliminary Studyby
Abstract
Due to its similar characteristics to titanium, niobium has become an attractive alternative in photocatalytic processes. Research indicates that titania has an optimal percentage of phases resulting in a commercial catalyst, P25, that contains more than 70% anatase with a minor amount of rutile and a small amount of amorphous phase. On the other hand, for Nb2O5, percentage optimization was little explored in the literature, which consists of studying the phases obtained via heat treatment individually and in diffe [...] 1603 8150 |
The Impact of Allograft CXCL9 during Respiratory Infection on the Risk of Chronic Lung Allograft Dysfunctionby
Abstract
Background: The long term clinical significance of respiratory infections after lung transplantation remains uncertain. Methods: In this retrospective single-center cohort study of 441 lung transplant recipients, we formally evaluate the association between respiratory infection and chronic lung allograft dysfunction (CLAD). We furthermore hypothesized that bronchoalveolar lavage fluid (BALF) CXCL9 concentrations are augmented during respiratory infections, and that episodes of infection with elevated BALF CXCL9 ar [...] 1603 10806 |
Carbon Footprint Study of Korean Green Tea Industry Using the Methods of the Life Cycle Assessment and Calculating Carbon Absorption in Agricultural LandAbstract
Due to recent global warming and climate change events, about 127 countries have declared themselves carbon neutral since the Paris Agreement was signed. Furthermore, agriculture is directly or indirectly affected by climate change. In particular, the importance of carbon neutrality is very high due to the high carbon absorption potential of forestry biomass. In the global beverage market, green tea is the second most consumed beverage after water, and the potential of tea tree biomass to absorb carbon during culti [...] 1601 11851 |
Enhancing University Students’ Mental Health under Artificial Intelligence: Principles of Behaviour TherapyAbstract
The increasing prevalence of mental health issues among university students has become a growing concern globally. This review explores the potential of Artificial Intelligence (AI) integrated with principles of behaviour therapy to address mental health challenges among university students. The paper examines how AI technologies, including chatbots, virtual reality, and machine learning algorithms, can be harnessed to provide accessible, personalized, and effective mental health interventions. Furthermore, it disc [...] 1600 16268 |
Early Nutrition during Critical Illness in Pediatric Patients Post-Hematopoietic Cell TransplantationAbstract
Background: Hematopoietic cell transplant (HCT) patients are a high-risk population for poor nutrition and decreased survival. There is little data on how nutrition in pediatric HCT patients affects need for critical care interventions and outcomes. Methods: We hypothesized that patients who did not meet goal nutrition by 72 hours post-admission to the pediatric intensive care unit (PICU) had increased in-hospital mortality and increased need for critical care interventions. We performed a retrospective cohort stud [...] 1598 8208 |
Homeopathy and Photobiomodulation for Healing Diabetic Wounds in vitroAbstract
Photobiomodulation (PBM), as well as plant extracts of Calendula officinalis (Calen), Hypericum perforatum (Hyper), and Echinacea purpurea (Echi-p), have been used to accelerate wound healing. However, the use of homeopathic preparations of these medicinal plants, in combination with PBM, is unknown. The objective of this study was to investigate the combined wound healing potential of these therapies in vitro. Various cell models were created in vitro in commercially available human skin fibroblasts (WS1). PBM was [...] 1597 16659 |
Sleep Disorders in Children with Central Nervous System TumorsAbstract
Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hypothalamus and surrounding regions are prone to excessive daytime sleepiness. Sleep-related breathing disorders, especially those involving abnormal control of breathing, may occur in patients with tumors of the brainste [...] 1596 12938 |
A Systematic Review of the Biological Processes Involved in Deep-Brain Stimulation for Parkinson's disease: A Focus on the Potential Disease-Modifying Effectsby
Abstract
Deep-Brain Stimulation (DBS) is an important treatment option for the management of Parkinson’s disease (PD) and is a common symptomatic treatment. However, an increasing number of studies have examined the biological processes to assess if DBS can also modify the natural history of PD by acting on its pathophysiological mechanisms. Relevant literature published up to November 2020 was systematically searched on databases such as PubMed, ISI Web of Knowledge, Academic Search Index, and Science Citation Index. The f [...] 1596 11083 |
Stress Analysis and Life Prediction of a Ceramic Matrix Composite Vane Using a Micromechanics-Based Approachby
Abstract
The results of stress analysis of a ceramic matrix composite (CMC) vane using a physics-based model developed for two-dimensional woven CMCs are presented. The model considers the inherent defects and micromechanical damage in woven CMCs along with time-dependent deformation of the constituents. Predictions include damage state under general load conditions and the global deformation response of the vane. Strain-gage data from burst tests are compared to strain predictions obtained using the model. Results from tim [...] 1594 10293 |
From Bioactive Molecules to Their Nutritional Effect, Biodynamic Interpretation Between Productional and Functional Aspects of NutrientsAbstract
In this article, the long journey from the production of food ingredients to their transformation into nutrients was described. The essential function of nutrients is to satisfy the primary needs of living organisms, namely energy, morphology and reproduction, through the consumption of food. Fulfilling its primary role, food must contain nutrients that are essential for the well-being of the living, along with others that are not essential but are still important for proper metabolism. These substances are known a [...] 1594 16473 |
Acetonitrile Combustion over Copper-Based Nanocatalysts: A Structure-Performance Relationship StudyAbstract
In this paper, the relationship between activity and structure of Cu2+ in different chemical environments of Cu-BETA, La2CuO4, and CuO nanocatalysts was systematically investigated for acetonitrile combustion. The study revealed that exchanged and octahedral species of Cu2+ coexist in Cu-BETA, while octahedral species are dominant in CuO and La2CuO4. All nanocatalysts achieved high conversion rates of acetonitrile, which rapidly increased with temperature. CuO and La2CuO4 led to the formation of undesired products [...] 1593 9806 |
Stenting of the esophagus in the course of the malignant dysphagia in elderly patientsAbstract
Esophageal cancer is a disease with difficult clinical management, and palliative therapy is the only predominant treatment. This retrospective study analyses the results of clinical management of elderly patients (>75 years of age) who were treated with esophageal stenting for malignant dysphagia due to primary esophageal cancer, including squamous cell carcinoma (SCC), esophageal adenocarcinoma (EAC), as well as secondary esophageal malignant strictures due to non-small cell lung cancer (NSCLC). Patients with [...] 1593 11523 |
Recruiting Perinatal Fathers to Interventions and Research: A Conceptual Model of Engagement and Integrative Review of Barriers Encountered and Strategies UsedAbstract
The perinatal period represents a unique developmental window for families and an opportunity to reach and engage fathers in research and preventive interventions. The distinctiveness of this period stems from the changes and stressors that parents experience which affect their openness to enroll in interventions (e.g., adaptive parenting, physical and mental health, relationship skills, and economic self-sufficiency) and participate in research. While long understudied, paternal research in the perinatal period ha [...] 1593 10824 |
A Combined Power and Ejector Refrigeration Cycle System for Thermal Energy Recovery from the Waste Heat of Internal Combustion EngineAbstract
In this paper, due to the importance of energy recovery from internal combustion engines and the increasing human growing need for power and refrigeration, a two-cycle power and refrigeration system consisting of an organic Rankine cycle and an ejector refrigeration cycle is investigated analytically. The proposed system with the ability to use the ejector as an effective and economical system, can produce simultaneous power and refrigeration by drawing thermal energy from the exhaust gas and engine coolant in the [...] 1592 9799 |
A Qualitative Study Exploring the Impact the Self-Compassion App Has on Levels of Compassion, Self-Criticism, and WellbeingAbstract
Self-guided, smartphone apps may be helpful in reducing symptoms associated with psychological distress and may boost wellbeing, and levels of compassion. To our knowledge this is the first study to examine the impact a 28-day app based on Compassion Focused Therapy and Compassionate Mind Training has on participant’s levels of compassion, wellbeing, and self-criticism. The Self-Compassion App includes exercises, meditations, quotes, a daily wisdom, and audios, all of which aim to help individuals develop com [...] 1591 13898 |
Dearomatization of the Kerosene Fraction: Kinetic StudiesAbstract
The kinetics of dearomatization of a kerosene fraction processed using a zeolite catalyst (0.9 HZSM-5) at different temperatures (160-200°C), the molar ratio between the aromatic hydrocarbons present in the kerosene fraction and n-decene (1:(0.5-4)), and the reaction time (1-3 h) were studied. Based on the obtained data, a kinetic model for kerosene dearomatization is proposed. It is assumed that the single-center Riedel mechanism is followed. The stage associated with the interaction between n-decene adsorbed on t [...] 1590 9139 |
Case Studies in the Ethics of Assisted Reproduction, by Louise P. King & Isabelle C. Band, Switzerland: Springer Cham, 152 Pages, Ebook, 978-3-031-41215-8Abstract
"Case Studies in the Ethics of Assisted Reproduction" explores the moral and ethical implications of assisted reproductive technologies (ART), such as in vitro fertilization (IVF), surrogacy, and genetic screening. These findings outline ethical dilemmas, including the importance of informed consent, and highlight a multidisciplinary approach involving law, bioethics, reproductive endocrinology, and reproductive biology. Using case studies, the findings address ethical challenges in ART practice, such as the transf [...] 1590 7262 |
Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALSby
Abstract
There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) intravenously and intrathecally. This is the first snapshot of pre-and post-stem cell transplantation in an ALS patient through transcriptomic, epigenomic, and proteomic follow-up elucidating the effect of stem cells in [...] 1590 11341 |
Single-Case Neuropsychological Assessment of a Patient with a Posterior Parietal Lesion Using Behavioral Testing and Resting-State fMRIby
Abstract
This study integrated functional connectivity measures using resting-state fMRI and behavioral data from a single-case observation of patient (PER) one year after right-hemispheric hemorrhage in the intraparietal sulcus and superior parietal lobule (IPS/SPL). PER showed no sign of clinical neglect. Her behavioral performance in the visuo-manual pointing task and in the letter discrimination task under conditions of endogenous and exogenous attentional cueing was compared between the left (affected) and right (unaff [...] 1590 10220 |
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