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Table of Content

Open Access Communication

In vitro Electroporation in the Presence of CRISPR/Cas9 Reagents as a Safe and Effective Method for Producing Biallelic Knock-Out Porcine Embryos

Received: 01 September 2020;  Published: 18 February 2021;  doi: 10.21926/obm.genet.2101123

Abstract

The production of genetically modified (GM) pigs is considered valuable in biomedical research for the development of model animals for various diseases and pigs with resistance against viral infection. The porcine genome may be modified using several methods, such as somatic cell nuclear transfer (SCNT) using GM cells as the SCNT donor, direct injection of the transgene or the genome editing components (GEC) into fertilized eggs referred to as zygotes, the in vitro electroporation (EP) of the zygotes in the presen [...]

2743 13959

Open Access Review

Migraine as a Common Extra-Intestinal Presentation of Celiac Disease

Received: 18 August 2020;  Published: 09 February 2021;  doi: 10.21926/obm.neurobiol.2101087

Abstract

Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcificat [...]

1966 17860

Open Access Project Report

Development of a Pediatric Integrative Oncology Program: Pearls, Barriers, and Future Directions

Received: 02 December 2020;  Published: 08 February 2021;  doi: 10.21926/obm.icm.2101005

Abstract

Children with cancer can experience intense suffering. Currently, despite our best efforts, symptoms associated with both cancer and its treatment result in physical, psychological, and emotional discomfort that can be difficult to manage with traditional Western medicine alone. Developing integrative services within a pediatric hematology-oncology program may help improve cancer-related symptoms by combining different modalities targeting overall health with traditional oncology care. This study details the initia [...]

2467 12898

Open Access Research Article

Umbilical Cord Blood as an Alternate Donor Sources for High Risk Elderly Patients Undergoing Allogeneic Stem Cell Transplantation for Hematological Malignancies

Received: 04 November 2020;  Published: 07 February 2021;  doi: 10.21926/obm.transplant.2101136

Abstract

Allogeneic stem cell transplantation remains the only curative option for many hematological malignancies. Umbilical cord blood (UCB) is an alternate donor source with potentially increased morbidity in elderly patients. We evaluated outcomes in alternate donor sources, prior to the initiation of haploidentical transplantation at our institution, of matched unrelated donor (MUD) and UCB in elderly patients (mean age 64, range 60-75). One hundred and eighty-four patients were included (MRD: 57; MUD: 69; UCB: 58). Th [...]

1678 10083

Open Access Original Research

Mental Health Effects of COVID-19 Pandemic on Healthcare Workers

Received: 20 December 2020;  Published: 07 February 2021;  doi: 10.21926/obm.icm.2101004

Abstract

Healthcare workers (HCWs) have been adapting to the changing needs of people worldwide in response to the COVID-19 pandemic. The purpose of this descriptive study was to evaluate how HCWs are managing dietary self-care needs during the increased stress-load of the COVID-19 pandemic and determine if nutritional changes are being made that could place them at higher risk for mental health problems. A cross-sectional epidemiological nonprobability snowball sampling design was used to expand access to participants. Occ [...]

2160 12268

Open Access Case Report

Dysphagia Aortica: A Case Report and Review of Treatment Options

Received: 29 October 2020;  Published: 05 February 2021;  doi: 10.21926/obm.geriatr.2101157

Abstract

A 64-year-old, cachectic man with body mass index (BMI)

1692 13815

Open Access Review

The Effects of Mediterranean Diet on the Human Gut Microbiota; a Brief Discussion of Evidence in Humans

Received: 09 November 2020;  Published: 05 February 2021;  doi: 10.21926/obm.hg.2101056

Abstract

The Mediterranean diet (MD) is considered one of the healthiest dietary patterns due to its rich provision of phytochemicals, antioxidants, vitamins, fiber, polyunsaturated, omega-3, and short-chain fatty acids through a variety of foods. The supply of such nutrients and bioactive components can support gut health and reduce systemic inflammation, with accumulating evidence from several human studies demonstrating the utility of the Mediterranean diet in the prevention of chronic and metabolic diseases. Further stu [...]

1431 8218

Open Access Original Research

Toward Next Generation Plasmonic Nanopore Slit Platform with a ~10 nm Slit-Width

Received: 22 December 2020;  Published: 05 February 2021;  doi: 10.21926/rpm.2101004

Abstract

We fabricated various nanoaperture plasmonic platforms for single-molecule detection. We fabricated nanoapertures like nanopores on a pyramid and nanoslits on an Au flat membrane using a Ga ion focused ion beam drilling technique, followed by irradiating with a high energy electron beam, dependent on the electron beam current density to obtain nanoapertures with a few nanometer sizes (circular nanopore, nanoslit pores). We examined their optical characteristics with varying aperture sizes and sample thicknesses. We [...]

7717 21340

Open Access Review

Telomerase and Cancer: A Complex Relationship

Received: 26 October 2020;  Published: 03 February 2021;  doi: 10.21926/obm.geriatr.2101156

Abstract

Telomere elongation is protective of genomic stability, whereas telomere shortening increases genomic instability and thereby increases cancer risk. Long telomeres lower the risk of clinical cancer, while short telomeres are part of a causal cascade of intracellular events that result in oncogenesis and, ultimately, clinical cancer. Telomerase therapy is not only unlikely to result in an increased risk of cancer but is likely to lower the risk of cancer compared to age-matched patients not treated with telomerase t [...]

1972 28535

Open Access Commentary

Deconstructing then Priming Gut Microbiota Resilience

Received: 11 December 2020;  Published: 01 February 2021;  doi: 10.21926/obm.hg.2101055

Abstract

The human intestinal microbiota represents a complex microbial community that plays an essential role in the maintenance of host health. Over the last decade, metagenomic and metabolomic analyses have revealed the influence of intestinal microbial diversity and composition on a range of biological functions in the host. While overall taxonomic composition of the intestinal microbiome is informative, changes in spatial dynamics within the community also have profound biological significance as microbial functions ar [...]

1433 8481

Open Access Case Report

Case Report of Lambert Eaton Myasthenic Syndrome in a Patient with Small Cell Lung Cancer on Immune Checkpoint Inhibitor Therapy

Received: 28 October 2020;  Published: 31 January 2021;  doi: 10.21926/obm.neurobiol.2101086

Abstract

Lambert Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder involving loss of functional pre-synaptic P/Q-type voltage-gated calcium channels. Many cases occur as a paraneoplastic disorder, often in small cell lung cancer (SCLC). Recently, immune checkpoint inhibitors (ICI) have emerged as treatment of choice for various malignancies. While generally well tolerated, certain ICI-treated patients experience neurologic immune-related adverse events (irAEs). Here, we explore therapeuti [...]

2444 18638

Open Access Original Research

Melting/Solidification Processes of PEG 1500 in Vertical and Horizontal Annular Enclosure

Received: 01 December 2020;  Published: 31 January 2021;  doi: 10.21926/jept.2101009

Abstract

In this paper, the primary aim is to look at the fundamental melting/solidification processes of polyethylene glycol 1500 (PEG 1500) for energy storage - insulation to prolong the cooling time of pipelines in unexpected shut-down conditions, prevent/minimize the wax deposition, and hydrate formation. Polyethylene glycol 1500 was selected because its melting temperature is >317 K making it a suitable candidate as lagging material to prevent wax deposition and hydrate formation in subsea oil pipelines. Experim [...]

2254 12047

Open Access Original Research

Modeling of Ceria Reduction in a Solar Thermochemical Reactor via DEM Method

Received: 09 November 2020;  Published: 30 January 2021;  doi: 10.21926/jept.2101008

Abstract

Solar thermochemical reactor provides an attractive approach that utilizes the most common solar radiation as the thermal driving force to motivate the reaction between CO2 and metal oxides, which is also called metal oxide redox pair-based thermochemical cycles. The CeO2/CeO2-δ is widely used in the two-step redox process due to its advantages including fast-redox kinetics, high crystallographic stability of a wide range of reacting oxygen non-stoichiometry, and relatively high oxygen solid-state conductivit [...]

2323 13567

Open Access Review

Prenatal and Preimplantation Genetic Diagnosis of Huntington's Disease

Received: 15 December 2020;  Published: 28 January 2021;  doi: 10.21926/obm.neurobiol.2101085

Abstract

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic te [...]

2460 20693

Open Access Opinion

Yoga: A Potential Adjunct Therapy to Current Rehabilitation Pathways in Cardiac Conditions and Stroke

Received: 06 August 2020;  Published: 28 January 2021;  doi: 10.21926/obm.geriatr.2101155

Abstract

Yoga is a form of movement-based mindfulness practice that enhances the mind-body connection to benefit overall health and well-being. Although the practices of yoga are ancient traditions in the Buddhist and Hindu philosophies, scientific research regarding the impacts of yoga among people with poor cardiovascular and cerebrovascular health has only recently been undertaken. In this article, we highlight the current evidence on the potential impact of yoga on physical and psychological well-being for older adults [...]

1757 10332

Open Access Original Research

Quantum Theory of EEG with Application to the Single-Trial ERP Analysis

Received: 17 July 2020;  Published: 27 January 2021;  doi: 10.21926/obm.neurobiol.2101084

Abstract

The probabilistic formalism of quantum mechanics is used to quantitatively link the electroencephalogram (EEG) with the underlying microscale activity of cortical neurons. Previous approaches applied methods of classic physics to reconstruct the EEG in terms of explicit physical models of cortical neurons and the volume conductor. However, the multiplicity of cellular processes with extremely intricate mixtures of deterministic and random factors prevented the creation of consistent biophysical parameter sets. To a [...]

1887 14565

Open Access Review

Ni-Silica-based Catalysts for CH4 Reforming by CO2 with Enhanced Stability: Recent Designs and the Impacts of Ni Confinement, Promoters, and Core-Shell Structures

Received: 01 September 2020;  Published: 26 January 2021;  doi: 10.21926/jept.2101007

Abstract

CO2 reforming of CH4, also referred to as the Dry Reforming of Methane (DRM), is considered an excellent method to produce H2 and CO (syngas), which are known to be used for the production of higher alkanes and oxygenates. Despite nickel’s moderate toxicity, Ni-based heterogeneous catalysts are considered excellent candidates for use in DRM due to their reasonable performances and economic advantages. However, these materials also present severe drawbacks, such as sintering of the active phase and coke (carbo [...]

3238 16437

Open Access Original Research

Quaternary Hydrides Pd1-y-zAgyCuzHx Embedded Atom Method Potentials for Hydrogen Energy Applications

Received: 10 November 2020;  Published: 25 January 2021;  doi: 10.21926/jept.2101006

Abstract

The Pd-H system has attracted extensive attention. Pd can absorb considerable amount of H at room temperature, this ability is reversible, so it is suitable for multiple energy applications. Pd-Ag alloys possess higher H permeability, solubility and narrower miscibility gap with better mechanical properties than pure Pd, but sulfur poisoning remains an issue. Pd-Cu alloys have excellent resistance to sulfur and carbon monoxide poisoning and hydrogen embrittlement, good mechanical properties, and broader temperature [...]

2258 13158

Open Access Research Article

Malignancies and Pediatric Liver Transplantation: Promising Management with the mTOR-inhibitor Everolimus

Received: 07 June 2020;  Published: 25 January 2021;  doi: 10.21926/obm.transplant.2101135

Abstract

Some malignancies such as hepatoblastoma may be an indication for liver transplantation (LT) or some, for example, post-transplant lymphoproliferative disease (PTLD) may develop after successful LT. An immunosuppressive therapy after LT can promote the recurrence of the primary malignancy. The mammalian target-of-rapamycin inhibitors (mTORi) are immunosuppressive agents with anti-tumor properties. We examined the impact of everolimus (EVL) together with calcineurin inhibitors on allograft outcome and patient surviv [...]

1683 10263

Open Access Technical Note

Spatio-Temporal Metocean Measurements for Offshore Wind Power

Received: 24 November 2020;  Published: 22 January 2021;  doi: 10.21926/jept.2101005

Abstract

This paper presents the case for the use of HF radar to provide wave, current and wind measurements and maps during the surveying, resource and impact assessment, construction, maintenance and performance assessment phases of an offshore fixed or floating wind farm or other marine renewable project. The data presented are from the Celtic Sea which is currently the focus of a lot of offshore wind interest. The data are from a dual radar system deployed at the Wave Hub site off the Cornwall coast since 2011, a single [...]

2448 14643

Open Access Original Research

Tribological Behaviour of Sputter Coated ZnO Thin Films

Received: 13 August 2020;  Published: 22 January 2021;  doi: 10.21926/rpm.2101003

Abstract

The tribological properties of ZnO thin film coated on an aluminium work piece by RF magnetron sputtering were studied as a function of deposition power, substrate coating temperature, heat treatment and rotation speed. The variation in the coefficient of friction of ZnO films produced under various levels of coating parameters and conditions were experimentally determined using a pin-on-disk tribometer. The results showed that with change in deposition conditions and heat treatment, there are significant microstru [...]

2088 12126

Open Access Review

Dysphagia in Inclusion Body Myositis, A Disease of the Elderly

Received: 11 November 2020;  Published: 21 January 2021;  doi: 10.21926/obm.geriatr.2101154

Abstract

Inclusion body myositis is one of the most common acquired myopathies seen in the aging population. The muscle weakness is of insidious onset, frequently starting in the legs, but over time gradually progresses to eventually involve all skeletal muscles of the limbs, face, swallowing and respiratory muscles, leading to significant morbidity and mortality. Complications resulting from dysphagia are the leading cause of poor quality of life and mortality, while highly prevalent, are still underappreciated and underre [...]

2663 20462

Open Access Editorial

Neuro-Photobiomodulation: Stimulation of the Brain Using Different Frequencies

Received: 18 January 2021;  Published: 20 January 2021;  doi: 10.21926/obm.icm.2101003

Abstract

Neuro-photobiomodulation (PBM) is a relatively novel optical stimulation method that is not yet generally accepted in conventional medicine. Therefore, evidence-based research in this sub-area, which is important for laser medicine, is necessary in order to provide appropriate scientific evidence for a better understanding of neuro-PBM. In this editorial, a summary of the recent results with stimulation using different frequencies (e.g., 40 Hz, 136.1 Hz) is presented. The contribution is intended to stimulate resea [...]

2075 10168

Open Access Research Article

Which Physiological Swallowing Parameters Change with Healthy Aging?

Received: 24 November 2020;  Published: 19 January 2021;  doi: 10.21926/obm.geriatr.2101153

Abstract

Research suggests there are age-related changes in swallowing that do not constitute impairment (“presbyphagia”). The goal of this study was to explore the influence of age on quantitative measures of healthy swallowing by controlling for the effects of sex and sip volume in order to determine the specific characteristics of presbyphagia. Videofluoroscopy recordings of thin liquid swallows from 76 healthy adults (38 male), aged 21-82 were analysed. Blinded duplicate ratings of swallowing safety, efficiency, kinemat [...]

4053 50298

Open Access Project Report

SOFC Stack and System Modeling, Fault Diagnosis and Control

Received: 31 July 2020;  Published: 18 January 2021;  doi: 10.21926/jept.2101004

Abstract

This report is an account of research and development activities undertaken by the Centre for Process Systems Computations, Department of Chemical Engineering at Curtin University, Western Australia in the area of solid oxide fuel cells. The focus of work of the group included 1)effect of cell macrostructure and microstructure on electrochemical performance with a view to optimise both macro- and micro-structure 2) electrochemistry modeling for simulating electrochemical performance 3) internal reforming aspects im [...]

3285 18093

Open Access Original Research

Deflection of a Concrete T-beam with Prestressed and Non-prestressed Fiber Reinforcement Polymers at Elevated Temperatures

Received: 15 November 2020;  Published: 15 January 2021;  doi: 10.21926/rpm.2101002

Abstract

Prestressed concrete members have gained popularity as an efficient and effective way of designing a structural member with the best engineering and material properties. The method of prestressing a structural concrete member has the capability of controlling increased service loads with less depth over longer spans. However, deflections from over-loading or loading over time give a disadvantage to the common steel reinforced concrete members by the effect of corrosion as the structural concrete develop cracks. To [...]

1913 13089

Open Access Research Article

Transmitted Donor Immunology Not Infection: Common Persistence of Donor Hepatitis C Antibody Production in Aviremic Lung Transplant Recipients

Received: 16 September 2020;  Published: 13 January 2021;  doi: 10.21926/obm.transplant.2101134

Abstract

Since 2018 The American Society of Transplant has recommended that Hepatitis C Virus seropositive positive, non-viremic donors (HCVAb+/NAT-) be considered non-infectious and safe for transplantation. This report describes clinical outcomes and HCV serological and virological outcomes following lung transplantation (LTx) utilizing such donors. This retrospective cohort study describes seven HCVAb+/NAT- donors used for bilateral LTx. Donor information was sourced from the national organ donation service and recipient [...]

2003 10143

Open Access Research Article

N-Type Calcium Channels Control GABAergic Transmission in Brain Areas related to Fear and Anxiety

Received: 13 September 2020;  Published: 12 January 2021;  doi: 10.21926/obm.neurobiol.2101083

Abstract

N-type (Cav2.2) calcium channels are key for action potential-evoked transmitter release in the peripheral and central nervous system. Previous studies have highlighted the functional relevance of N-type calcium channels at both the peripheral and central level. In the periphery, N-type calcium channels regulate nociceptive and sympathetic responses. At the central level, N-type calcium channels have been linked to aggression, hyperlocomotion, and anxiety. Among the areas of the brain that are involved in anxiety a [...]

2501 11407

Open Access Original Research

Online State of Charge Prediction in Next Generation Vehicle Batteries Using Deep Recurrent Neural Networks and Continuous Model Size Control

Received: 31 July 2020;  Published: 12 January 2021;  doi: 10.21926/jept.2101003

Abstract

This investigation presents a data-driven Long-short Term Memory battery model for predicting State of Charge for lithium-ion batteries LiFePO4 for next-generation vehicle operations. Our modified algorithm builds and updates a model using multivariate inputs that include physical properties, voltage, current, and ambient temperature during operations. The primary research goal is to improve prediction performance on future values from multiple training examples using an online learning scheme. Initial results demo [...]

2235 11663

Open Access Review

The Puzzle of Immunosuppressive Drugs

Received: 30 August 2020;  Published: 11 January 2021;  doi: 10.21926/obm.transplant.2101133

Abstract

Kidney transplantation has become the preferred treatment option in end-stage chronic renal failure as it provides significant improvements over dialysis in terms of both quality and duration of life. Even after several randomized studies conducted in the last 20 years, the combination of CNI, MMF, and steroids continues to be considered the gold standard for kidney transplantation. However, novel molecules aimed at minimizing renal and cardiovascular toxicity, particularly with CNI sparing, are being identified. T [...]

1797 10431

Open Access Original Research

Knowledge of Osteoporosis and Lifestyle Behaviours Impacting Peak Bone Mass among Young Adults

Received: 27 July 2020;  Published: 11 January 2021;  doi: 10.21926/obm.geriatr.2101152

Abstract

Osteoporosis is a major public health problem through its association with fragility fracture. Low peak bone mass (PBM) is a major contributor to later osteoporosis risk. Despite this, most studies concentrate on older people when the window of opportunity to impact PBM has passed. This study aimed to understand what adolescents and young adults understand about PBM, the risk of osteoporotic fracture and how lifestyle factors impact PBM. Such information may inform educational interventions to reduce future risk of [...]

1917 12322

Open Access Research Article

Stepping Out: A Pilot Program to Reduce Falls Risk in People with Mild Cognitive Impairment

Received: 14 September 2020;  Published: 08 January 2021;  doi: 10.21926/obm.geriatr.2101151

Abstract

Cognitive impairment significantly increases the risk of accidental falls in older adults, and falls outcomes are more severe in this population. However, few interventions exist to reduce falls among individuals with cognitive impairment. To address this gap, we developed Stepping Out, by modifying the evidenced-based falls prevention program, Stepping On, tailoring it to meet the cognitive needs of individuals with mild cognitive impairment (MCI) who are at risk for falls. Our objectives were to determine whether [...]

2060 11480

Open Access Case Report

Effect of Physical Exercise Training on Bullying and Depression in a Classroom: A Case Report

Received: 21 June 2020;  Published: 07 January 2021;  doi: 10.21926/obm.icm.2101002

Abstract

In a previous study conducted to assess the impact of physical exercise on the symptoms of depression and anxiety in preadolescents in the school environment, which included a subgroup of participants comprising eleven randomly selected teens (aged 9–11) and all enrolled in primary education, it was immediately observed that one participant referred to as Andy was being bullied and teased, and the teachers were completely unaware of this scenario. All the participants of the study were volunteers, and were subjecte [...]

2479 11407

Open Access Editorial

Acknowlegement to Reviewers of OBM Integrative and Complementary Medicine in 2020

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/obm.icm.2101001

Abstract

The editors of OBM Integrative and Complementary Medicine would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a [...]

1778 6901

Open Access Editorial

Acknowlegement to Reviewers of OBM Genetics in 2020

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/obm.genet.2101122

Abstract

The editors of OBM Genetics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition di [...]

1367 6373

Open Access Editorial

Acknowlegement to Reviewers of Journal of Energy and Power Technology in 2020

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/jept.2101002

Abstract

The editors of Journal of Energy and Power Technology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a cer [...]

1249 5773

Open Access Editorial

Acknowlegement to Reviewers of Recent Progress in Materials in 2020

Received: 07 January 2021;  Published: 07 January 2021;  doi: 10.21926/rpm.2101001

Abstract

The editors of Recent Progress in Materials would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate o [...]

1213 6817

Open Access Perspective

Relax into Yoga for Seniors: An Evidence-Informed Update for Enhancing Yoga Practice Benefits by Reducing Risk in a Uniquely Vulnerable Age Group

Received: 13 August 2020;  Published: 07 January 2021;  doi: 10.21926/obm.geriatr.2101150

Abstract

Teaching yoga to seniors is often considered an entry-level job for a yoga instructor since older adults are unlikely to attempt complicated, “advanced” postures. Unfortunately, this ill-informed attitude puts the most vulnerable students with the least-trained instructors who may unknowingly put their students at risk. Even experienced yoga instructors often do not understand the vulnerabilities of older adults, and many commonly taught yoga poses may present risks for seniors. This could explain why participants [...]

3456 140771

Open Access Editorial

Acknowlegement to Reviewers of Advances in Environmental and Engineering Research in 2020

Received: 04 January 2021;  Published: 06 January 2021;  doi: 10.21926/aeer.2101001

Abstract

The editors of Advances in Environmental and Engineering Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can do [...]

1212 6547

Open Access Editorial

Acknowlegement to Reviewers of OBM Geriatrics in 2020

Received: 04 January 2021;  Published: 06 January 2021;  doi: 10.21926/obm.geriatr.2101149

Abstract

The editors of OBM Geriatrics would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition [...]

1599 6951

Open Access Editorial

Acknowlegement to Reviewers of OBM Transplantation in 2020

Received: 04 January 2021;  Published: 06 January 2021;  doi: 10.21926/obm.transplant.2101132

Abstract

The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recogni [...]

1351 6377

Open Access Original Research

Assessment of Cu(In, Ga)Se2 Solar Cells Degradation due to Water Ingress Effect on The CdS Buffer Layer

Received: 28 October 2020;  Published: 06 January 2021;  doi: 10.21926/jept.2101001

Abstract

The effect of water ingress on the surface of the buffer layer of a Cu(In, Ga)Se2 (CIGS) solar cell was studied. Such degradation can occur either during the fabrication process, if it involves a chemical bath as is often the case for CdS, or while the modules are in the field and encapsulants degrade. To simulate the impact of this moisture ingress, devices with a structure sodalime glass/Mo/CIGS/CdS were immersed in deionized water. The thin films were then analyzed both pre and post water soaking. Dynamic second [...]

2311 1634961

Open Access Short Report

Pediatric Thoracoscopic Repair of Diaphragmatic Herniation Following Liver Transplantation

Received: 09 August 2020;  Published: 05 January 2021;  doi: 10.21926/obm.transplant.2101131

Abstract

Diaphragmatic Hernia (DH) after Liver Transplantation (LT) is a rare complication with unclear pathophysiology. Among 261 LT, we recognized six DH during the post transplant period (2.30%). All patients with DH had received a left lateral segment (LLS) reduced graft. The mean graft weight was 340g with a mean graft-to-recipient body weight ratio (GBWR) of 4.20%. LLS grafts, a GBWR > 4%, previous abdominal surgery and direct trauma during surgery can be enumerated as potential risk factors for DH post-LT. These chil [...]

1486 8576

Open Access Communication

Medical Hypothesis: Deep Brain Stimulation for Intractable Migraine

Received: 26 October 2020;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101082

Abstract

Deep Brain Stimulation (DBS) has been introduced as an innovative treatment for several neurological disorders, including Parkinson’s disease, essential tremor, and dystonia and it has been proven effective in helping individuals affected by these disorders; hence, enhancing their quality of life. DBS has also been investigated for the treatment of cluster and other primary headaches. Electrodes are surgically implanted into brain structures, for example the posterior hypothalamus in case of cluster headache. Hypot [...]

2111 13874

Open Access Editorial

Acknowlegement to Reviewers of OBM Neurobiology in 2020

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.neurobiol.2101081

Abstract

The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition di [...]

1059 6387

Open Access Editorial

Acknowlegement to Reviewers of OBM Hepatology and Gastroenterology in 2020

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/obm.hg.2101054

Abstract

The editors of OBM Hepatology and Gastroenterology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificat [...]

1131 5938

Open Access Editorial

Acknowlegement to Reviewers of Advances in Chemical Research in 2020

Received: 04 January 2021;  Published: 05 January 2021;  doi: 10.21926/acr.2101011

Abstract

The editors of Advances in Chemical Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of r [...]

686 5206

Open Access Review

Management of the Sensitized Cardiac Transplantation Recipient

Received: 11 September 2020;  Published: 04 January 2021;  doi: 10.21926/obm.transplant.2101130

Abstract

Preoperative sensitization of the cardiac transplant recipient, defined as the presence of anti-Human Leukocyte Antigen (HLA) antibodies before transplant, represents a significant management challenge for physicians. Sensitization prolongs the pre-transplant wait time and is associated with postoperative transplant complications and death. It is critical that sensitized heart transplant candidates be identified and optimized before surgery. In this review, we describe the risk for sensitization, discuss the means [...]

2107 11110

Open Access Research Article

Feasibility of Implementing Therapeutic Yoga in Assisted Living Facilities

Received: 19 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101148

Abstract

The purpose of this convergent mixed methods study was to explore the feasibility of implementing a chair yoga intervention in assisted living facilities (ALFs), evaluating reach, demand, acceptability, practicality, treatment fidelity, and safety. A yoga intervention was implemented twice a week for eight weeks at four different ALFs. Feasibility data were collected in the form of observational data, reflective field notes, and focus groups. Quantitative and qualitative data strands were compared to determine if r [...]

2223 11757

Open Access Research Article

Yoga Training Impacts Physical Function 12 Months Post Intervention for Care Partners of those with Mild Cognitive Impairment

Received: 30 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101147

Abstract

Physical exercise has been demonstrated to help maintain cognition in people with Mild Cognitive Impairment (pwMCI). We previously demonstrated yoga’s benefit in maintenance of memory related activities of daily living in pwMCI. Our research also has shown yoga helps sustain positive psychological well-being of care partners at 12 months. In this analysis, we sought to examine the impact of yoga training on physical performance in pwMCI and their care partners. In this multisite, randomized clinical trial, we enrol [...]

2013 11686

Open Access Review

Interactions of Per- and Polyfluoralkyl Substances (PFAS) with Landfill Liners

Received: 16 September 2020;  Published: 31 December 2020;  doi: 10.21926/aeer.2004007

Abstract

This review synthesises the available published research on interactions of per- and polyfluoroalkyl substances (PFAS) with landfill liners, with the view to inform on the expected behaviour of these persistent environmental pollutants in landfills. The review addresses the nature and significant types of PFAS compounds that are destined for landfills, as well as their by-product. It discusses the known and anticipated interactions with separate landfill liner components, namely geomembranes, geosynthetic clay line [...]

4373 22219

Open Access Research Article

Transcriptome Signatures of Dysregulated Brain Dynamics Induce Entangled Network States.

Received: 15 June 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004077

Abstract

Marks of brain disorders may be visible through abnormal networks characterized by states with distinct signatures or connectivity patterns. Apart from neurodegenerations, drug abuse or eventually addiction may exert complex perturbative effects over human health, including damage to various organs and especially brain inflammation, volume shrinkage and functional deficits. These can also be regarded as signs of accelerated ageing, which involve multiple comorbidities associated with long-lasting cognitive impairme [...]

1919 9072

Open Access Review

Palmitoylethanolamide for Neurological Disorders

Received: 04 October 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004076

Abstract

Neurological tissue along with the cartilage remains one of the tissues that escapes human efforts of regeneration after injury. The human body, after an injury, can repair its tissues only to a certain extent that can help in recovering the function of organs. However, this is not the case in some organs, such as the brain and spinal cord. For a long time, basic medical science has been investigating the regeneration process that helps the human body, which is mainly through the pharmacological agents, proteins/ot [...]

1775 13537

Open Access Original Research

Electrochemical Oxidation of Perfluorooctanesulfonate by Magnéli Phase Ti4O7 Electrode in the Presence of Trichloroethylene

Received: 02 November 2020;  Published: 29 December 2020;  doi: 10.21926/aeer.2004006

Abstract

This study examined the degradation of perfluorooctanesulfonate (PFOS) in electrochemical oxidation (EO) processes in the presence of trichloroethylene (TCE). The EO experiment was performed in a gas-tight reactor using Magnéli phase titanium suboxide (Ti4O7) as the anode. The experimental data demonstrated that 75% of PFOS (2 μM) was degraded at 10 mA/cm2 current density in 30 min without TCE present in the solution, while the presence of 76 μM TCE apparently inhibited the degradation of PFOS, reducing its r [...]

3166 18420

Open Access Review

Peripheral Nerve Dysfunction after Spinal Cord Injury

Received: 02 October 2020;  Published: 29 December 2020;  doi: 10.21926/obm.neurobiol.2004075

Abstract

Spinal cord injury (SCI) leads to an immediate loss of sensory and motor function below the level of injury mostly affecting people in the prime of life. In addition to the primary injury there is accumulating neurophysiological and histological evidence of dysfunction in the peripheral nerves, not related to direct damage from the primary injury, which exacerbates muscle wasting, and contributes to further functional loss and poor recovery. Among the potential contributing factors are systemic inflammation, and mo [...]

2472 16591

Open Access Review

Solar Thermal Energy Stills for Desalination: A Review of Designs, Operational Parameters and Material Advances

Received: 28 September 2020;  Published: 29 December 2020;  doi: 10.21926/jept.2004018

Abstract

The demand for high-quality freshwater is increasing due to global population growth, intensifying agricultural practices and expanding industrial development. Additionally, many global regions have low levels of rainfall which makes them arid and incapable of supporting large human populations or agriculture. Currently, large quantities of fossil fuels are used to generate the power needed to drive energy intensive desalination processes that deliver high-quality freshwater to many of these regions. However, the u [...]

2701 31176

Open Access Review

Spotlight on Older Adults in Swallowing Research

Received: 07 November 2020;  Published: 25 December 2020;  doi: 10.21926/obm.geriatr.2004146

Abstract

Generalisations and misconceptions about ageing and swallowing can influence clinical opinion. Assumptions about swallowing function based on someone’s age risk overmedicalising or, conversely, undertreating older patients. Evidence suggests that increased prevalence of swallowing problems in older age is attributed to pathology known to affect swallowing function, or an unrelated serious illness and combination of health factors, and not ageing itself. This review highlights factors clinicians should consider when [...]

2310 16194

Open Access Original Research

How to Prioritize Voluntary Dietary Modification

Received: 03 August 2020;  Published: 25 December 2020;  doi: 10.21926/aeer.2004005

Abstract

Environmentally motivated voluntary diet modifications are the focus of much research and public discourse. Yet the nuanced multi-faceted, multi-dimensional nature of agriculture-earth interactions, and limited public environmental knowledge likely combine to undermine the efficacy of environmentally motivated dietary shifts, squandering limited good will. To counter this, here I devise two related indices for crudely estimating importance of various environmental impacts of alternative dietary choices. Based on th [...]

1631 10615

Open Access Case Report

Anticoagulation Rationale in an Elderly Patient with Stroke, Cerebral Amyloid Angiopathy, and Antiphospholipid Syndrome: A Case Report

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

Abstract

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

1948 8367

Open Access Research Article

Perceived Psychosocial Benefits for Individuals with Parkinson’s Disease Following Therapeutic Yoga: A Qualitative Analysis

Received: 19 August 2020;  Published: 22 December 2020;  doi: 10.21926/obm.geriatr.2004144

Abstract

Using a qualitative approach, this study explored the perceived impacts of a therapeutic yoga intervention for individuals with Parkinson’s disease (PD), and examined the beneficial components of the intervention. Eighteen individuals with PD who completed an eight-week yoga intervention participated in focus groups to determine the general effects, transference of effects, and psychosocial impact of the intervention. Additionally, programmatic aspects of the intervention were explored. A conventional content analy [...]

2019 11544

Open Access Review

The Role of Surveillance Bronchoscopy Following a Lung Transplantation

Received: 01 July 2020;  Published: 21 December 2020;  doi: 10.21926/obm.transplant.2004129

Abstract

Pulmonary transplantation (LuTx) is established as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, and pulmonary arterial hypertension. Acute rejection and infection are implicated as potential risk factors in developing complications such as bronchiolitis obliterans syndrome (BOS) and chronic rejection, leading to high morbidity and mortality rates after the LuTx. Thus, surveillance procedures after transplanta [...]

1878 15732

Open Access Review

Clinical Significance of Internal Friction Connection and Micro-Threads in Implant-Supported Prostheses: A Literature Review

Received: 13 August 2020;  Published: 17 December 2020;  doi: 10.21926/rpm.2004024

Abstract

A connection structure using both a screw and friction is advantageous to secure an abutment to an implant. Understanding the biomechanics of the implant-abutment connection is necessary for the long-term clinical survival of a dental implant with decreased complications. The internal conical friction connection structure and micro-threads have shown favorable biological hard tissue response with exceptional structural features. The internal conical connection structure maintains the soft tissue seal and the margin [...]

2978 18114

Open Access Research Article

Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Hippocampus in Amyotrophic Lateral Sclerosis

Received: 12 October 2020;  Published: 17 December 2020;  doi: 10.21926/obm.geriatr.2004143

Abstract

Amyotrophic lateral sclerosis (ALS) is reported to be probably linked to frontotemporal lobar degeneration (FTLD). Since FTLD is characterized by severe frontotemporal degeneration along with hippocampal atrophy (HA), the present study used post-mortem 7.0-tesla magnetic resonance imaging to investigate whether a certain degree of HA occurs in the ALS brains as well. The examined post-mortem brain samples comprised 9 from the ALS cases and 17 from the age-matched controls. The hippocampus samples were examined on t [...]

1555 8987

Open Access Review

The Therapeutic Potential of the Stem Cell Secretome for Spinal Cord Repair: A Systematic Review and Meta-Analysis

Received: 26 October 2020;  Published: 14 December 2020;  doi: 10.21926/obm.neurobiol.2004080

Abstract

There is currently no effective treatment for spinal cord injury leaving around 90% of patients with permanent disabilities. Stem cell therapies are showing promise in preclinical studies of central nervous system injury and there is increasing evidence suggesting the improvements in functional recovery are mediated by paracrine actions. In this systematic review and meta-analysis, we aimed to determine the overall efficacy of stem cell secretome therapies in promoting recovery in preclinical models of spinal cord [...]

2064 13884

Open Access Original Research

Theoretical investigation of the single and double ionization spectra of M(CO)6, M = W and Cr

Received: 26 April 2020;  Published: 14 December 2020;  doi: 10.21926/acr.2004010

Abstract

In this work, we study the single and double ionization spectra of the , with complexes by applying the four-component algebraic diagrammatic construction and Fock-space coupled cluster methods to extend earlier studies based on less demanding approaches. The computed single and double ionization potentials are in good agreement comparing with the available experimental results. The electronic structures of the cationic molecular systems are carefully investigated by computing accurately single and double ionizatio [...]

1517 7310

Open Access Research Article

Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy

Received: 24 September 2020;  Published: 10 December 2020;  doi: 10.21926/obm.geriatr.2004142

Abstract

The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. The examined post-mortem brains included 30 AD-CAA cases and 20 AD [...]

1626 8033

Open Access Research Article

Auricular Acupuncture with Beads Supports Sustained Weight Loss

Received: 17 May 2020;  Published: 09 December 2020;  doi: 10.21926/obm.icm.2004045

Abstract

Obesity causes serious long-term health problems in people worldwide. Since the effect of dietary advice is possibly limited, weight loss can be a major challenge; therefore, additional weight control techniques may be beneficial. We conducted four experiments to evaluate if auricular acupuncture point stimulation with simple metal beads (AA) rather than the popular use of intradermal needle (DA) to stimulate auricle would support weight loss. In this retrospective study, weight change in Japanese women (aged 18 to [...]

3066 30602

Open Access Original Research

The Effect of Curing Temperature on the Morphology and Electro-Optical Properties of a Flexible UV-Cured Polymer Dispersed Liquid Crystal (PDLC)

Received: 11 October 2020;  Published: 08 December 2020;  doi: 10.21926/rpm.2004023

Abstract

In this work, the experimental data on flexible PDLC films at the industrial scale and the effect of cure temperature (Tc) on the morphology and electro-optical properties of a UV-cured PDLC system via polymer-induced phase separation (PIPS) method were studied. Under constant UV radiation intebsity and thickness, the morphological parameters such as dimension, number density, and volume fraction of the phase-separated liquid crystal droplets as well as the optical transmissions and switching voltages as a function [...]

2045 11990

Open Access Review

Nutritional Interventions in Cancer Cachexia Prevention and Treatment

Received: 28 September 2020;  Published: 07 December 2020;  doi: 10.21926/obm.icm.2004044

Abstract

Cancer cachexia contributes to 30% of cancer-related deaths. There is currently no treatment or standard of care for cancer cachexia. Many nutritional interventions show promise for the treatment and or prevention of cachexia. Supplementation with omega-3 fatty acids, protein and vitamins either alone or in combination has shown some beneficial effects in the prevention and treatment of cancer cachexia. The mechanisms through which many nutritional interventions work to attenuate cachexia are just beginning to be u [...]

2658 18487

Open Access Short Communication

An Algorithm to Optimize Pain Detection and Management in Older Patients in Routine Practice

Received: 09 July 2020;  Published: 07 December 2020;  doi: 10.21926/obm.geriatr.2004141

Abstract

Acute or persistent pain is a common occurrence and is often undertreated in older patients, especially those with an inability to communicate verbally (ICV). Regular comprehensive pain assessment, including self-rating and/or behavior scales, is critical but difficult to implement in routine clinical practice. The choice of the most appropriate scale for each patient is not easy, even for trained and skilled medical personnel. Indeed, the use of scales for short pain-behavior exposes to pain under-detection due to [...]

2024 12019

Open Access Case Report

Donor Cell-Derived Acute Myeloid Leukaemia with 3q26.2 Involvement/MECOM Rearrangement ‐ A Case Report and Literature Review

Received: 13 October 2020;  Published: 07 December 2020;  doi: 10.21926/obm.transplant.2004128

Abstract

Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). DCL might represent up to 5% of the post-HSCT disease relapses, but case numbers reported in the literature might underestimate the frequency. The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. Although many theories have been proposed for leukemogenesis of DCL, the underl [...]

1767 9996

Open Access Original Research

Bridging Biomedical and Person-centered Care Approaches via Namaste Care with Family Participation: An Asian Experience in Advanced Dementia Treatment

Received: 27 October 2020;  Published: 04 December 2020;  doi: 10.21926/obm.geriatr.2004140

Abstract

A locally-adapted, multisensory, psychosocial intervention called Namaste Care program was developed to improve the daily life of persons with advanced dementia (PwAD) through arranging meaningful activities and physical interactions by healthcare staff (Namaste Carers). Congruent with Asian values, the families of PwAD were invited to participate in Namaste Care sessions. The study aimed to explore the influence of Namaste Care on cognitive status and quality of life (QOL) of PwAD, and perceptions and attitudes of [...]

2488 14629

Open Access Short Communication

Successful i-GONAD in Brown Norway Rats by Modification of in vivo Electroporation Conditions

Received: 23 September 2020;  Published: 03 December 2020;  doi: 10.21926/obm.genet.2004121

Abstract

Improved-Genome editing via Oviductal Nucleic Acids Delivery (i-GONAD) was developed for in situ genome editing of the preimplantation embryos present within the oviductal lumen of mice. This method is based on intra-oviductal instillation of genome editing components and subsequent in vivo electroporation (EP) in the entire oviduct. Therefore, i-GONAD differs from the previous methods (i.e., zygote microinjection and in vitro EP) in producing genome-edited mice, which relied on ex vivo handling of preimplantation [...]

2929 14265

Open Access Case Report

Psychiatric Disorders in Mӧbius Sequence: Intermittent Presentation of Auto-Aggressive Outbursts

Received: 27 March 2020;  Published: 03 December 2020;  doi: 10.21926/obm.neurobiol.2004079

Abstract

Anecdotal evidence suggests the possible association of psychiatric disorders with Mӧbius sequence, although the evidence is not conclusive. Intermittent presentation of auto-aggressive outbursts, in particular, could be related to Mӧbius sequence, different from the common psychotic symptoms. The present report describes the clinical case of a young man with Mӧbius syndrome who exhibited a complex representation of severe mental retardation and concomitant psychiatric disorders. Extremely rare psychiatric disorder [...]

1854 8496

Open Access Original Research

Genetic Stability, Inheritance Patterns and Expression Stability in Biotech Crops

Received: 11 September 2020;  Published: 02 December 2020;  doi: 10.21926/obm.genet.2004120

Abstract

Demonstration of the stability of traits newly introduced into a plant genome via genetic engineering approaches comprise a significant portion of the safety assessment that these products undergo prior to receiving the requisite regulatory approvals enabling commercial authorization. Different regions of the world have different regulatory requirements and many ask similar questions from multiple and overlapping perspectives. The entire central dogma, that is stability at the DNA level, mRNA level and protein leve [...]

2260 13675

Open Access Review

The Roles of Collagen in Islet Transplantation

Received: 02 October 2020;  Published: 27 November 2020;  doi: 10.21926/obm.transplant.2004127

Abstract

Islet transplantation is a cellular replacement therapy for severe diabetes mellitus. Although the clinical outcome of islet transplant has been improving, the transplant efficacy of this treatment is not superior to that of pancreatic organ transplantation, a similar transplant therapy. Various factors have been characterized as ‘islet transplantation specific’, which includes lack of revascularization and ischemia, innate inflammation, or autoimmunity, affect the therapeutic outcome of this treatment. Among them, [...]

2254 12506

Open Access Original Research

Variations in Secondary Health Resource Utilization Post Clozapine Initiation

Received: 10 September 2020;  Published: 26 November 2020;  doi: 10.21926/obm.neurobiol.2004078

Abstract

This study looked at secondary care utilization metrics as an effectiveness indicator of Clozapine initiation in 77 patients over the following year compared to the year prior to initiation. It was found that there was a marginal drop in psychiatric bed utilization, alongside reduced crisis team use. Medical and psychiatric outpatient use increased, as did physical health interventions. Overall, compared with costs over the year preceding Clozapine initiation, an estimated saving per patient of £3,867 (5,065) was a [...]

1803 7765

Open Access Original Research

Synthesis of Tris(arylphosphite)-ligated Cobalt(0) Complexes [Co2(CO)6{P(OAr)3}2], and their Reactivity towards Phenylacetylene and Diphenylacetylene

Received: 07 September 2020;  Published: 25 November 2020;  doi: 10.21926/acr.2004009

Abstract

The dinuclear complexes [Co2(CO)6{P(OAr)3}2] (1a, Ar = Ph; 1b, Ar = o-Tol) were prepared and reacted with PhC≡CH and PhC≡CPh to yield dimetallatetrahedranes [{(ArO)3P}(OC)2Co-Co(μ-RC≡CPh)(CO)2{P(OAr)3}] (3a, Ar = Ph, R = H; 3b, Ar = o-Tol, R = H; 3c, Ar = Ph, R = Ph; 3d, Ar = o-Tol, R = Ph). The main reaction of diphenylacetylene was accompanied by a side reaction, leading to the dissociation of a P(OAr)3 ligand for the formation of mono(phosphite) complexes [{(ArO)3P}(OC)2Co-Co(μ-PhC≡CPh)(CO)3] (2b, R = Ph; 2d, R [...]

1694 8822

Open Access Research Article

Climate Cloud Model Forecast Verification-an Engineering Perspective

Received: 13 September 2020;  Published: 24 November 2020;  doi: 10.21926/aeer.2004004

Abstract

The processes relevant to the verification of cloud forecasts generated by climate models are discussed from an engineering perspective. These processes include an assessment of cloud product requirements to be evaluated, the creation of a verification test plan including procedures and data to be analyzed, the development of independent sources of validation or truth datasets, and the quantitative comparisons between the cloud forecast products and the truth data needed to establish model performance. The engineer [...]

1850 10863

Open Access Research Article

Further Understanding of Uncertainties in the Impedance Spectrum of the Polymer Electrolyte Fuel Cell due to Inductive Effects and Oxygen Diffusion Time Constant

Received: 31 July 2020;  Published: 24 November 2020;  doi: 10.21926/jept.2004017

Abstract

In this study, uncertainties during the assessment of the electrochemical impedance spectrum of the polymer electrolyte fuel cell (PEFC) attributed to inductive artefacts at high frequencies and inductive loops at low frequencies as well as oxygen diffusion time constant are discussed. A validated impedance model represented as an equivalent electrical circuit of a PEFC allowed the simulation of the effect of inductive artefacts, inductive loops and oxygen diffusion time constant on electrochemical impedance spectr [...]

2782 13020

Open Access Review

Research Requirements to Move the Bar forward Using Aqueous Formate Salts as H2 Carriers for Energy Storage Applications

Received: 01 September 2020;  Published: 23 November 2020;  doi: 10.21926/jept.2004016

Abstract

In this perspective on hydrogen carriers, we focus on the needs for the development of robust active catalysts for the release of H2 from aqueous formate solutions, which are non-flammable, non-toxic, thermally stable, and readily available at large scales at reasonable cost. Formate salts can be stockpiled in the solid state or dissolved in water for long term storage and transport using existing infrastructure. Furthermore, formate salts are readily regenerated at moderate pressures using the same catalyst as for [...]

2391 12991

Open Access Research Article

Impact of COVID-19 Lockdowns and Australian Bushfires on Aerosol Loading over the Downwind Oceanic Regions

Received: 21 August 2020;  Published: 23 November 2020;  doi: 10.21926/aeer.2004003

Abstract

Nearly 40 years of aerosol optical thickness (AOT) climate data record (CDR) from AVHRR satellite observations over the global ocean is used to study the impact of COVID-19 lockdowns and Australian bushfires on aerosol loading over downwind oceanic regions. Recent similar impact studies, by contrast, were mainly focused on the urban and suburban areas near the emission sources. AOT is used as a proxy for aerosol loading in our study. We found that AOT variations due to anthropogenic emission reduction during the lo [...]

1813 10674

Open Access Editorial

Challenges of Organ Transplantation in COVID-19 Era

Received: 01 November 2020;  Published: 19 November 2020;  doi: 10.21926/obm.transplant.2004126

1710 8774

Open Access Original Research

Multi-Species Probiotic Modulates Cytokine Production and the Interplay between Immune and Colon Cancer Cells

Received: 28 June 2020;  Published: 19 November 2020;  doi: 10.21926/obm.hg.2004053

Abstract

The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased produc [...]

1469 7813

Open Access Review

Rheumatic Diseases in the Elderly

Received: 13 August 2020;  Published: 18 November 2020;  doi: 10.21926/obm.geriatr.2004139

Abstract

Musculoskeletal conditions represent one-third to more than one-half of all non-communicable disease multimorbidities in the elderly, worsening their disability because of pain and limited physical function, often concurring with their mental decline. Musculoskeletal conditions significantly contribute to frailty and global disability, second only to mental health conditions. Furthermore, premature mortality, generally due to an increased risk of developing cardiovascular disease, has been documented in several rhe [...]

2653 19472

Open Access Review

Current Assessment of Clinical Pancreatic Islet Allotransplantation

Received: 20 September 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004125

Abstract

Clinical islet allotransplantation represents a minimally invasive, efficacious alternative to pancreas transplantation for restoring glycemic control and insulin independence in select patients with type 1 diabetes that is complicated by intractable impaired hypoglycemia awareness and/or severe hypoglycemic events refractory to stabilization by other means. Over the last decade, islet transplantation outcomes have steadily improved in part due to refinements in the selection of optimal donors, islet isolation tech [...]

2434 14476

Open Access Review

In vivo Hepatocyte Genome Manipulation via Intravenous Injection of Genome Editing Components

Received: 09 August 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004119

Abstract

The liver is a major organ with a wide range of functions, including detoxification, protein synthesis, and bile production. Liver dysfunction causes liver diseases such as hepatic cirrhosis and hepatitis. To explore the pathogenesis of these liver diseases, and the therapeutic agents against them, mice have been widely used as animal models. Genetic manipulation is easy in mice via the administration of nucleic acids (NAs) in the tail-vein. In particular, hydrodynamics-based gene delivery (HGD) is a method based o [...]

2423 12884

Open Access Review

Mauss and Organ Transplants: Ideas of Connectivity between Recipients and Donors and the “Spirit of the Gift”

Received: 22 July 2020;  Published: 16 November 2020;  doi: 10.21926/obm.transplant.2004124

Abstract

This article aims to describe the relationship between donors and their recipients in the context of organ transplants. This analysis is made in the light of Marcel Mauss’s work, offering an expansion on an analysis of his discussion on the “spirit of the gift” and his idea that gifts require reciprocation. It is argued that some recipients of donated organs receive a personal element from the donor in that there is a transfer or sharing of the donors’ personality and spiritual qualities. The article examines the n [...]

2207 11353

Open Access Research Article

Effects of a Six-Week Progressive Resistance Training Program on Functional Fitness among Community-Dwelling Older Adults

Received: 06 May 2020;  Published: 16 November 2020;  doi: 10.21926/obm.geriatr.2004138

Abstract

Research has indicated that older adult participation in resistance training provides foundational strength for performance of activities of daily living. The purpose of this study was to investigate the effects of a six-week progressive resistance training intervention on functional fitness among community-dwelling older adults. From 2010–2015, twelve sessions of a six-week resistance training intervention included 95 community-dwelling older adult participants (37 male, 58 female; Mage=73.5+7.2). Resistance [...]

2471 11739

Open Access Original Research

H-Ras Pre-mRNA Contains A Regulatory Non-coding RNA

Received: 25 June 2020;  Published: 16 November 2020;  doi: 10.21926/obm.genet.2004118

Abstract

Non-coding RNAs (ncRNAs) have emerged as one of the most abundant regulatory molecules. However, their roles and functions are significantly different from those of proteins. Moreover, around 95% of the human genome contains non-coding DNA. ncRNAs contribute by far the majority of human transcriptional units, and the functions of the most are yet unknown. Here, we highlight that an important RNA sequence region, encompassing an exon-intron hairpin loop (also called IDX-rasISS1), of the H-Ras pre-mRNA may encode an [...]

2135 9016

Open Access Editorial

Dynamic Pulse Reaction – Update 2020

Received: 11 November 2020;  Published: 13 November 2020;  doi: 10.21926/obm.icm.2004043

Abstract

The Nogier reflex or reflex auriculo-cardiac (RAC) or the dynamic pulse reaction is a physiological phenomenon that is not generally accepted in conventional medicine. Therefore, evidence-based research in this sub-area is important for auricular medicine as it provides appropriate scientific evidence for better acceptance. In this editorial, a RAC measurement based on a modified smartphone registration and analysis is presented. The contribution is intended to stimulate researchers to continue working in this inte [...]

2054 11173

Open Access Case Report

Liver Transplantation as a Cure for Neurologically Advanced Wilson’s disease. Learning More from Experience

Received: 05 July 2020;  Published: 12 November 2020;  doi: 10.21926/obm.transplant.2004123

Abstract

Clinical presentation and progression of Wilson’s disease can be diverse in different groups of patients. While young children most likely to present with acute or chronic liver failure, older children and adults may exhibit extrahepatic manifestation like neuropsychiatric, cardiac, renal, pancreatic and several others. Diagnosis of Wilson’s disease is based on the combination of specific clinical findings, laboratory and genetic testing. There are different modalities of treatment available for this condition. Liv [...]

1519 10109

Open Access Research Article

Estimating the Intensity of Hurricanes from Historical Radar Data Using the Hyperbolic-logarithmic Approximation of Spiral Rainbands

Received: 28 July 2020;  Published: 10 November 2020;  doi: 10.21926/aeer.2004002

Abstract

To increase the amount of information on the intensities of tropical cyclones (TC) used in climate research, the possibility of additional estimates of the intensity of a TC by exploring historical data of conventional (non-Doppler) airborne and coastal radars is considered. Based on the hyperbolic-logarithmic spiral (HLS) model of the streamline in the TC, an assessment of the maximum wind speed in hurricanes Cleo (1958), Carolina (1975) and Alicia (1983) was made. Literature sources containing radar signatures of [...]

2037 12247

Open Access Communication

Appropriate Vancomycin Use and Incidence of Vancomycin-Resistant Enterococci in Liver Transplant Recipients

Received: 24 July 2020;  Published: 09 November 2020;  doi: 10.21926/obm.transplant.2004122

Abstract

Liver transplant recipients (LTRs) are at risk for vancomycin-resistant Enterococcus (VRE) infections which can lead to significant morbidity or mortality. Antibiotic exposure, including vancomycin, is associated with greater risk of VRE infection. This study aimed to assess the appropriateness of vancomycin use and rates of VRE infection in this population. We performed a retrospective cohort study of 327 patients who underwent liver transplantation at our center from January 1, 2012 to June 30, 2017. Sixty (18.3% [...]

1486 8714

Open Access Research Article

Feasibility of an 8-week Yoga Intervention among Middle-aged and Older Adults

Received: 13 August 2020;  Published: 06 November 2020;  doi: 10.21926/obm.geriatr.2004137

Abstract

Feasibility studies play a critical role in determining whether the target population is likely to engage with larger scale efficacy and effectiveness trials. Feasibility data for yoga interventions designed and conducted with older adults is limited. In this paper we present feasibility and acceptability data from an 8-week randomized controlled trial (RCT) conducted with middle aged and older adults. Participants n=118 (Mean age: 62.0 years) were randomized to either a Hatha yoga or Stretching Control group with [...]

1957 12289

Open Access Review

The Physiology of Esophageal Reflexes

Received: 17 August 2020;  Published: 02 November 2020;  doi: 10.21926/obm.hg.2004052

Abstract

Several digestive tract reflexes involving the esophagus and its sphincter muscles have been identified, but to date, no comprehensive review has addressed most of these reflexes. The current review presents the known physiology of different esophageal reflexes in which either the esophagus or its sensory or motor portion of the reflex response is elaborated. The current review comprehensively examines the known and possible mechanisms underlying major esophageal reflexes, highlights the huge gaps in current knowle [...]

2296 9125

Open Access Review

Celiac Disease and Associated Extraintestinal Manifestations, with Special Reference to Neurological Disorders

Received: 13 July 2020;  Published: 30 October 2020;  doi: 10.21926/obm.neurobiol.2004074

Abstract

Celiac disease (CD), also known as gluten-sensitive enteropathy and nontropical sprue, is one of the most important entities of the wide spectrum of gluten-related disorders (GRDs). It is well known that neurological manifestations can be present either at the onset of CD, or appear during the development of the pathology, and the neurologic findings can show a profound difference. Clinical features show significant variation, ranging from typical manifestations of gastrointestinal involvement to several extraintes [...]

2004 12151

Open Access Review

Aspiration Pneumonia and the Traditional Chinese Medicine Banxia Houpu Tang

Received: 24 August 2020;  Published: 27 October 2020;  doi: 10.21926/obm.geriatr.2004136

Abstract

Aspiration pneumonia is one of the most common reasons for death in stroke patients. Recently, a traditional herbal medicine banxia houpu tang is remarked to prevent the aspiration pneumonia. This review tells the history of study of banxia houpu tang for prevent aspiration pneumonia.

2735 12512

Open Access Opinion

A Potential Role of Coenzyme Q10 Deficiency in Severe SARS-CoV2 Infection

Received: 01 August 2020;  Published: 26 October 2020;  doi: 10.21926/obm.icm.2004042

Abstract

There is a dramatic need for extensive research into the predictors of severe infection with SARS-CoV2 and therapeutic options for infected people. People who suffer from severe illness and higher mortality display a pattern of having specific co-morbidities (diabetes, obesity, hypertension) and are of higher age. Recent research has described methods of viral entry via receptors (ACE2, TMPRSS2) and the hyper-inflammatory state often associated with severe illness (increase in interleukins, increase in TNF-alpha). [...]

2432 16010

Open Access Research Article

Mechanical and Rheological Properties of 3D Printable Cement Composites

Received: 29 July 2020;  Published: 23 October 2020;  doi: 10.21926/rpm.2004022

Abstract

Additive manufacturing is a recent revolution in the construction field since cementitious materials became printable. This extrusion technique has enabled the construction of very complex geometry with a reduction in costs, time and labour interventions. This study aims to evaluate the possibility of reinforcing 3D printable cementitious composites with the use of nano and micro materials, particularly nano silica, micro silica and microfibrillated cellulose (MFC) which are known for their ability to enhance the f [...]

2343 11704

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