Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathy
Abstract
1501 7780
Comparison of Post-mortem 7.0-Tesla Magnetic Resonance Imaging of the Brains of Alzheimer Patients with and without Cerebral Amyloid Angiopathyby
Abstract
The influence of cerebral amyloid angiopathy (CAA) in Alzheimer’s disease (AD) remains unexplored. The present post-mortem study investigated possible differences in the degree of hippocampal atrophy (HA) between AD patients with and without CAA using 7.0-tesla magnetic resonance imaging (MRI). Also, the incidence of the hippocampal cortical micro-infarcts (HCoMIs) and hippocampal cortical micro-bleeds (HCoMBs) is compared to those in the neocortex. The examined post-mortem brains included 30 AD-CAA cases and 20 AD [...] 1501 7780 |
Evaluation of a Virtual Compassionate Living Group for Patients with Chronic PainAbstract
Chronic pain affects around 28 million people in the UK. Those living with chronic pain can frequently experience internalised self-stigma and negative self-evaluations as a result of the pain itself and due to difficult life experiences. Previous research has found Compassion Focused Therapy to be effective for people living with long term health conditions like chronic pain. The current study sought to evaluate a routine Virtual Compassionate Living Group for patients with chronic pain on the measures of self-com [...] 1298 7776 |
Biomarkers in the Management of the Lung Transplant Allograft: A Focus on Donor-derived Cell-free DNAAbstract
Advances in the use of molecular biomarkers to guide management of lung transplant recipients are emerging. One such biomarker, donor-derived cell-free DNA (dd-cfDNA), has the potential to alter traditional approaches of lung transplant management, including the detection of acute rejection or infection, surveillance monitoring strategies, risk stratification of vulnerable patient populations and molecular phenotyping of various forms of allograft injury. The emergence of novel genetic and epigenetic approaches uti [...] 1143 7772 |
Endoscopic Therapy for Recurrent Acute PancreatitisAbstract
Recurrent acute pancreatitis (RAP) is a clinical entity characterized by episodes of acute pancreatitis which occurs on more than one occasion. Recurrence of pancreatitis generally occurs in a setting of a normal anatomical and functional gland, however, a chronic disease at early stage may be found either on the occasion of the first episode of pancreatitis or during the follow-up. The etiology of RAP can be identified in up to 70% of cases; for the remaining cases the term “idiopathic” is used. Most common caus [...] 1412 7771 |
Leveraging Existing Abilities in Dementia (LEAD™): Changing the Way Rehabilitation Professionals Care for Persons Living with DementiaAbstract
Latest estimates indicate that 5-7% of the population are living with Alzheimer’s disease and related dementias worldwide with a doubling in incidence expected every 20 years. Rehabilitation professionals are challenged with the complex needs of these patients. It is commonly thought that patients with dementia do not benefit from rehabilitation because of cognitive decline, behaviors, lack of communication, or difficulties in learning; however, current literature indicates this is not accurate. With proper knowled [...] 1296 7770 |
The Holy Grail to Clinical Transplant Tolerance Is Paved with HLA EpitopesAbstract
The Holy Grail to Clinical Transplant Tolerance is Paved with HLA Epitopes 1185 7737 |
Highlights of Application of Homeopathy in Oncology Patients: An Interview with Prof. Michael FrassAbstract
Highlights of Application of Homeopathy in Oncology Patients: An Interview with Prof. Michael Frass 1151 7731 |
Fixed-Switching Frequency Finite-State Model Predictive Thrust and Primary Flux Linkage Control for LIMAbstract
The special design of linear induction machines (LIMs) leads to adverse effects caused by the longitudinal and end effects. These effects make the thrust control of the LIMs most attractive because its value decreases sharply with the speed increase. Thus, finite-state model predictive control (FS-MPC) is developed to increase the performance of the LIMs. However, the variable switching frequency is the main drawback of this control. Consequently, the main objectives of this paper are to propose FS-MPC with a const [...] 1183 7728 |
The Crucial Role of Vitamin D in Regulating Gut Microbiota in Inflammatory Bowel DiseaseAbstract
In recent years, there has been an alarming increase in the incidence of inflammatory bowel disease (IBD), which includes both Crohn's disease (CD) and ulcerative colitis (UC), particularly in Western countries. This chronic condition is intricately linked to the composition and health of the gut microbiota (GM) — a complex community of microorganisms residing in the gastrointestinal (GI) tract. Despite extensive research, the underlying pathogenesis of IBD remains poorly understood, making it a wide area of invest [...] 1143 7727 |
Pandemics 2020 –COVID 19 Silent Hypoxia and Polysubstance Use: A Unique Case Reportby
Abstract
The coronavirus (COVID-19) pandemic continues to bring challenges in identification and management of which the “happy hypoxic” or silent hypoxia presentation has been found to present its own unique challenge. A 67-year-old African American COVID-19 positive female presents to the emergency department (ED) with a chief complaint of decreased oral intake and responsiveness, oriented and stable, with oxygen saturations found to drop as low as 47%. The patient was successfully managed with supplemental oxygen and det [...] 1324 7724 |
The Biomolecular Basis of Gut Microbiome on Neurological Diseasesby
Abstract
The human gastrointestinal (GI) tract harbors many microorganisms, including viruses, protozoa, archaea, fungi, and bacteria. Altogether, these microbes constitute what we know as the gut microbiome (GM). These commensal communities have important implications for human health. They influence physiological processes through different mechanisms, including synthesizing neurotransmitters, regulating enzymatic pathways, and releasing molecules responsible for different signal pathways. The interaction between GM and b [...] 864 7715 |
Biocatalyzed Hydrolysis of Residual Oils and Proteins from Flax and Camelina Oilseed Press Cakes Using Lipase and ProteaseAbstract
In this study, a PoC (Proof of Concept) of a possible biomass valorization of flax and camelina oilseed press cakes was presented. Biocatalyzed hydrolysis of residual oils and proteins extracted from these wastes was studied. The biotransformation of oils was performed using commercial immobilized lipases, including Amano PS, Amano AK, and Candida Antarctica Lipase B (CALB). Acylglycerols were partially or fully hydrolyzed using Amano PS and AK. Triglycerides were not hydrolyzed by CALB, which behaved differently. [...] 1455 7698 |
Bilateral Corneal Perforation in a Patient with Chronic Ocular Graft-Versus-Host Disease: A Case Report and Literature Reviewby
Abstract
Graft-versus-host disease (GVHD) is a serious complication that may occur in patients receiving allogeneic hematopoietic stem cell transplant (HSCT). GVHD occurs because of the immunological reaction between the donor’s T cells and the recipient’s antigens; GVHD may develop in different tissues, including the eye. Corneal perforation is an uncommon but vision-threatening manifestation of GVHD. We reported the case of a 65-year-old male patient who developed corneal perforation sequentially in both eyes 3 years afte [...] 1067 7692 |
Clinical Practice Guidelines About Screening for Disruptive Behavior Problems at Well-Child Visits: A Rapid Review of the Literature on the Accuracy of Parents’ Behavioral ConcernsAbstract
The current recommendations of the Canadian Paediatric Society about monitoring children’s disruptive behaviors at well-child visits call for screening if behavioral concerns are being raised by parents. But do parents’ concerns about their child’s behavior constitute a reliable means for primary care providers (PCPs) to decide either in favor or against screening? We conducted a rapid systematic review of the literature by identifying documents that cited the landmark study by Glascoe and her col [...] 1299 7662 |
Wind Farm Layout Optimization Subject to Cable Cost, Hub Height, and a Feasible 3D Gaussian Wake Model ImplementationAbstract
We address the Wind Farm Layout Optimization (WFLO) problem and tackle the optimal placement of several turbines within a specific (wind farm) area by incorporating additional aspects of an economically driven target function. With this, we contribute three refinements for WFLO research: First, while many research contributions optimize the turbines' locations subject to maximum energy production or energy efficiency, we instead pursue a strategy of maximizing a profit objective. This enables us to incorporate inne [...] 1325 7662 |
Pyrethrin Type Compounds from the Municipal Solid Waste Ghazipur Landfill Inert Soil as Brain and Cancer 5-HT Receptor Binding AgentsAbstract
The Inert soil obtained from the Ghazipur Municipal Solid Waste landfill located in East Delhi, India has been used as the starting material for the work described in this paper. This mountain-like monster is often in the news for its bad smell, pollution of the groundwater in the area from its leachates, and the occasional fires in it endangering the lives of the people living nearby. Landfills produce many greenhouse gases (CO2, CH4, CO, HCHO, H2S, and NH3) which are poisonous and cause environmental pollution in [...] 1256 7662 |
Mental Health Disorders Following Exposure to Endocrine Disruptor ChemicalsAbstract
There is growing scientific concern regarding how endocrine-disrupting chemicals (EDCs) impact central nervous system (CNS) disorders. Both anecdotal and preclinical studies suggest a link between EDC exposure and major depressive disorder (MDD), potentially leading to neurodegenerative outcomes. EDCs primarily exhibit their biological effects by interacting with hormone receptors. Nonetheless, there is scientific evidence pointing to dysfunction in the hypothalamic-pituitary-gonadal-adrenal axis, which is linked t [...] 1070 7659 |
Multi-Species Probiotic Modulates Cytokine Production and the Interplay between Immune and Colon Cancer CellsAbstract
The current study aimed to investigate the effect of a multi-species probiotic (MSP) on cytokine production by human peripheral blood mononuclear cells (PBMCs) and their immune dialogue with HT-29 colon cancer cells. PBMCs were incubated with MSP and their effect on cell proliferation and TNFα, IL-1β, IL-2, IL-6, IFNγ, IL-10, and IL-1ra production was evaluated. The impact of MSP on the cytokine production by PBMC stimulated by HT-29 cells was detected. Not-stimulated PBMC incubated with MSP showed increased produc [...] 1436 7656 |
Plane Waves Scattered by a Spherical Inclusion in a Half Space of Poroelastic Materialby
Abstract
This paper concerns a poroelastic half-space in which plane compressional waves are scattered by a spherical inclusion. Addition theorems for the spherical wave functions are utilized to meet the boundary conditions on the plane, and the satisfaction of the given conditions on the boundary of the sphere leads to three infinite series equations, whose solution can be acquired by successive approximations. Further, its existence and uniqueness are discussed. 1712 7641 |
The Acceptability and Impact of a Video on Compassion Focused Therapy as a Psycho-Educative Tool to Deepen Awareness around Voice-HearingAbstract
In the compassion focused therapy (CFT) model of voice-hearing, a distressing relationship with voices is thought to be influenced by evolved threat-protection patterns, which are activated and attuned by socially threatening experiences, such as being harmed by others, as well being shamed, stigmatised, invalidated, and excluded. Therefore, the CFT approach is particularly interested in the role of voice-hearers’ relationships with others and self, as well as their social context of family/friends, professio [...] 1096 7638 |
Integration between Geriatric Oncology and Palliative Care: A Single Center Experience for Hospitalized Older Patients with Cancerby
Abstract
Comprehensive Geriatric Assessment (CGA) is utilized to plan social and health care of the elderly and to complete the diagnostic-therapeutic choice of oncologist also considering early integration with palliative care. Cancer patients (pts) hospitalized aged ≥70 years were screened by the G8 questionnaire to define if necessary CGA. CGA identified: fit, unfit and frail pts. We screened 95 pts by G8 and 93 (98%) were at risk. Pts at risk, evaluated by CGA resulted: 3 fit, 45 unfit and 45 frail. 3 fit pts received s [...] 1294 7620 |
Impact of Sex and Gender Differences on Heart Failure, Especially in Elderly PatientsAbstract
Heart failure is one of the major health threats in Western societies, and its prevalence is steadily increasing. Many data show the important impact of sex (biological) and gender (sociocultural) differences on most aspects (diagnosis, etiology, treatments, and outcomes) of heart failure. For example, compared to men, women with heart failure are older, have more co-morbidities, and develop different phenotypes of heart failure. Postpartum cardiopathy is unique in women. The iatrogenic effects of cancer therapies [...] 1167 7619 |
Organotin Polymers for the Control of Pancreatic Cancerby
Abstract
Pancreatic cancer is the fourth leading cause of death in the USA. Treatment is seldom successful. A wide variety of organotin polymers exhibit good inhibition of human pancreatic cancer cell lines AsPC-1 and PANC-1. The AsPC-1 is an adenocarcinoma pancreatic cell line and PANC-1 which is an epithelioid carcinoma pancreatic cell line. Synthesis is rapid employing commercially available reactants and the interfacial polymerization that is employed in the commercial synthesis of aramids and polycarbonates. 1330 7615 |
Physiological Response of a Natural Central Incisor Tooth to Various Loading Conditions: A 3D Finite Element Studyby
Abstract
This study evaluates the influence of different loading angles and the area of loading on the ensuing stress distribution and the physical response of a natural central incisor tooth, using a 3D finite element analysis. The CAD model of the incisor tooth assembly (including enamel, dentin, periodontal ligament, pulp, gingiva and jaw bone) was subject to an external (chewing) load of 100 N, over four different areas and at four different angles along the vertical. It was observed that the tooth experiences high von- [...] 872 7614 |
How Can Architectural Acoustics Reflect Levels of Stress and Relaxation in Indoor Environments? An EEG-Based Experimental StudyAbstract
The acoustic design of indoor environments encompassing spatial configuration, material properties, and sound absorption significantly influences auditory perception and psychological well-being. This study examines the interaction between architectural acoustics, musical stimuli, and neural responses within a controlled therapeutic context, focusing on their effects on stress reduction and relaxation. Electroencephalography (EEG) was utilized to measure brain activity in 24 participants exposed to six musical inst [...] 1142 7605 |
Controller Evaluation for Solar-Latent Thermal Energy Applicationsby
Abstract
In this study, the performance of a self-sufficient controller used for a solar-latent heat domestic hot water (DHW) production unit under real-world operating conditions was analyzed. The unit consists of a flat-plate solar collector and a latent heat storage tank. The controller is powered by a small solar panel and governs the charging and discharging of the system, ensuring maximum solar energy absorption, desired hot water temperature, and constant monitoring of the heat-storage tank’s capacity. The system is [...] 1168 7601 |
Assessment of Water Balance Dynamics and Resource Stress in the Gaza Strip, Palestineby
Abstract
Water scarcity is one of the most pressing global challenges, particularly in arid and semi-arid regions. In this context, the Gaza Strip, where groundwater is the only available natural water resource, faces severe water stress due to overexploitation and drought conditions. This study aimed to review the recent water budget for the Gaza Strip by collecting data for the years (2021-2022) which was analyzed, discussed, and compared with other studies. The results showed a sharp deterioration in the Gaza Strip in te [...] 1245 7598 |
Production and Characterization of Carboxymethylcellulase by Submerged Fermentation of Moniliophthora perniciosaAbstract
Microorganisms that are capable of degrading lignocellulolytic materials can produce extracellular cellulase complexes. Microorganisms are an excellent alternative for the production of cellulolytic complex, since these sources have a high power of multiplication. In this work, we researched the production by the fungus Moniliophthora perniciosa. The production and pH and temperature optimum optimization were studied by Response surface methodology and carboxymethylcellulase (CMCase) characterization. Thermal stabi [...] 1177 7580 |
Responsible Implementation of Expanded Screening Programs for Genetic Diseases at the Beginning of LifeAbstract
Technology makes it possible to expand many of the current screening programs. Initiatives for preconception screening of carrier status of recessive diseases, prenatal screening of aneuploidies and neonatal screening were initially undertaken by targeting one or at most, a few, conditions. Tandem mass spectrometry and genomic technologies, such as sequencing and panel testing, make it possible to increase the scope of these programs to include more disorders or markers. While inclusion of a larger number of condit [...] 1763 7575 |
Ageing: Longevity, Successful and PositiveAbstract
Ageing: Longevity, Successful and Positive 1345 7572 |
Local Authority Waste Management Strategies, the Circular Economy and the Generation of Energy from Waste in Englandby
Abstract
The purpose of this article is to examine the approach to waste management of local authorities in England, to investigate their strategic objectives, and to ascertain to what extent sustainability and circular economy practices are in evidence in this context. A qualitative, inductive research method is used, based on an examination of secondary documentation in three local authorities in England in Birmingham, Bristol and Newcastle upon Tyne. The findings reveal considerable common ground within the three authori [...] 1208 7564 |
Nonalcoholic Fatty Liver Disease and Inflammatory Bowel Disease: Complex Interactions, Evaluations, and Management DecisionsAbstract
Diseases of the liver are commonly encountered in patients with Inflammatory Bowel Disease (IBD). While the differential for IBD patients with elevated liver associated enzymes is broad, it is similar to that of the general population. This differential includes including non-alcoholic fatty liver disease (NAFLD), the most common liver disease in North America. When initial work-up for elevated liver associated enzymes is negative and patients have steatosis on ultrasound, we counsel IBD patients aggressively about [...] 1191 7562 |
Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of AcneAbstract
Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In regenerative medicine, biomolecules are fundamental to tissue regeneration. The use of growth factors from autologous platelet-rich plasma emerges as a promising alternative in the treatment of acne and scars. This study [...] 849 7559 |
Management of Calcareous Corneal Degeneration from Medication Washout to Corneal Transplantation. Case Series and Review of the LiteratureAbstract
Calcareous corneal degeneration is a rare disease characterized by calcium phosphate deposition into the deep corneal layers. Corneal calcification has a multifactorial origin and is associated with various systemic and ocular conditions. Several treatment options showed promising results in the management of this disorder. Herein, two cases of calcareous degeneration occurring postoperatively in patients undergoing surgery for retinal detachment (case #1) and glaucoma (case #2) were reported. Despite normal serum [...] 847 7558 |
Anxiety, Stress and Depression as the Notorious Barriers to Achieving a Massive Performance among Egyptian Construction Site WorkersAbstract
In today's corporate landscape, optimizing performance has emerged as a formidable challenge for organizations, often hindered by formidable barriers and psychological factors. This study explores the role of anxiety, stress, and depression in attaining performance among Egyptian construction site workers. The quantitative analysis utilizes cross-sectional data collected from workers working at different construction sites in Egypt. The study concludes with findings from 298 valid cases. Leveraging the structur [...] 992 7556 |
Variations in Secondary Health Resource Utilization Post Clozapine InitiationAbstract
This study looked at secondary care utilization metrics as an effectiveness indicator of Clozapine initiation in 77 patients over the following year compared to the year prior to initiation. It was found that there was a marginal drop in psychiatric bed utilization, alongside reduced crisis team use. Medical and psychiatric outpatient use increased, as did physical health interventions. Overall, compared with costs over the year preceding Clozapine initiation, an estimated saving per patient of £3,867 (5,065) was a [...] 1697 7546 |
Potential of Nutritious Indian Medicinal Plants to Boost Immunity in the Aftermath of Pandemics: A SWOC Analysisby
Abstract
The world has suffered a lot during the COVID-19 pandemic, for which nobody was prepared. Due to the lack of appropriate treatment, Indian medicinal plants have alleviated the burden due to their diverse health benefits. It has been observed that certain medicinal plants can effectively enhance immunity against microorganisms and viruses. Numerous scientific studies have supported the above claims. This paper presents the SWOC analysis of Indian medicinal plants for their immunity-enhancing effects so that the medi [...] 1341 7528 |
Comprehensive Geriatric Assessment of Elderly Adultsby
Abstract
The geriatric population is increasing all over the world. Aging people have special health requirements and comprehensive medical checkups prevent physical, functional and mental decline during the aging period. This study aimed to examine the fitness level and identify problems with the well-being of elderly persons. In this context, the study also attempted to determine the relationship between socio-demographic factors and the health status of elderly adults. In this cross-sectional study, 168 elderly adults (≥ [...] 1408 7524 |
Health-Related Quality of Life (HRQoL) in Elderly Patients Attending at Tertiary Health Care Centre in Central India During 1st Wave of COVID-19 Pandemic: A Prospective Observational Studyby
Abstract
The COVID-19 pandemic had imposed a city-level quarantine, local lockdown, and border closures for patient-level isolation to control virus spread. There is a lack of studies on the health-related quality of life (HRQoL) in the elderly in countries like India during COVID-19. After obtaining written informed consent from the elderly patients, data was recorded in the case record form-cum-questionnaire. The quality of life was assessed with the help of Centers for disease control and prevention (CDC) HRQoL-14 measur [...] 1176 7522 |
Acknowledgement to Reviewers of OBM Transplantation in 2021Abstract
The editors of OBM Transplantation would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2021. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recogni [...] 1011 7520 |
A Videoconference Physical Activity Intervention for Colorectal Cancer Survivors: A Pilot Randomized Controlled Trialby
Abstract
Physical activity (PA) after a colorectal cancer (CRC) diagnosis can improve physical function and quality of life and is associated with decreased mortality rates and longer disease-free survival. The accelerated use of videoconference technology during and following the COVID-19 pandemic offers an opportunity to explore the potential of a virtually supervised intervention to help survivors of CRC increase PA. A two-arm single blind pilot randomized controlled trial of individuals who had completed treatment for C [...] 1484 7512 |
Enhancing the Wettability of Polyetheretherketone (Peek) Membrane with Ozone for Improving Fuel Cell Performanceby
Abstract
Ozone was reacted with the aromatic membrane polyetheretherketone (PEEK) to form oxidized functional groups on the surface to enhance the attraction and transport of protons in fuel cells. Ozonation of unsaturated C-C sp2 bonds in PEEK formed a primary ozonide which dissociated to primarily produce O=C-O/O=C-OH moieties, and the root mean squared roughness factor (Rq) decreased from 7.4 nm, for the untreated sample, down to 3.1 nm. The oxidation of the surface and decrease in surface roughness made the surface incr [...] 1196 7510 |
Hypnotic Regression as an Autoethnographic Modality for Exploring Adverse Childhood Experiences as Proposed Effectors of Chronic Adult Obesity - Selected Case StudiesAbstract
Much has been written about the aetiological role of Adverse Childhood Experiences (ACEs) in the development of chronic adult physical and emotional health problems but current screening methods utilising questionnaires and formal interviewing often fail to show consensus across populations and surveys. This paper proposes that hypnotic regression might provide an alternative approach to ACE screening through its facility in revealing unsuspected and seemingly minor ACEs, which nevertheless can go on to have long t [...] 1409 7506 |
Can HCV Viremic Organs Be Used in Liver Transplantation to HCV Negative Recipients?by
Abstract
Liver transplantation has steadily increased worldwide resulting in a large number of patients on the waiting list. Due to the opioid epidemic in the US, the pool of Hepatitis C seropositive donors increased significantly in recent years. Direct acting antivirals played an instrumental role in making liver transplantation with hepatitis C positive allograft an acceptable option. Although hepatitis C positive liver transplantation to hepatitis C positive recipients is a common practice, there is limited data and agr [...] 1462 7503 |
A Robust Second-Order Conic Programming Model with Effective Budget of Uncertainty in the Optimal Power Flow ProblemAbstract
Integrating large-scale wind energy in modern power systems necessitates high-efficiency mathematical models to address classical assumptions in power systems. In particular, two main assumptions for wind energy integration in power systems have not been adequately studied. First, nonlinear AC power flow equations have been linearized in most of the literature. Such simplifications can lead to inaccurate power flow calculations and result in technical issues. Second, wind power uncertainties are inevitable and have [...] 1264 7500 |
The Effect of Oxygen-containing Additives in Feedstock on the Performance of the Catalytic Cracking ProcessAbstract
In this study, we found that adding catalytic cracking feedstock, vacuum gas oil, and naphthenic acids in the amount of 0.005–0.0075% vol. increased the liquid target fractions, i.e., gasoline and light gas oil. The decrease in the yield of hydrocarbon gas at a practically constant degree of conversion of the raw material indicated a small proportion of the reactions of re-cracking of the resulting products. This also indicated the resource-saving nature of the process, allowing a larger amount of gasoline fraction [...] 1291 7499 |
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