by Ji-Jie Pang  and Samuel M. Wu

Received: 24 November 2020;  Published: 21 May 2021;  doi: 10.21926/obm.neurobiol.2102098

We studied how GC death in glaucoma related to the intraocular pressure (IOP), eyeball volume (VS) and elasticity (volumetric KS and tensile ES), and eyeball volume-pressure relation. Glaucomatous GC loss was studied in DBA/2J (D2) mice with wild-type mice as controls. GCs were retrogradely identified and observed with a confocal microscope. The elasticity calculation was also done on published data from patients treated by a gas bubble injection in the vitreous cavity. The GC population in D2 mice (1.5- to 14-mont [...]

by Meira Erel  , Esther-Lee Marcus  and Freda DeKeyser-Ganz

Received: 11 November 2020;  Published: 01 March 2021;  doi: 10.21926/obm.geriatr.2101159

Decision-making by medical and health care staff forms the core of professional practice. Thought processes, including non-clinical considerations, significantly impact how clinical decisions are made. Such considerations become more relevant when addressing end-of-life care decisions for patients with advanced dementia (PAD). Though palliative care is recommended for this population, its implementation tends to vary. Given the medical staff’s significant influence in guiding clinical decisions, we examined thought [...]

by Daniel Navon  and Gareth Thomas

Received: 15 July 2021;  Published: 09 October 2021;  doi: 10.21926/obm.genet.2104140

In this article, we discuss the radical uncertainties unleashed by expanded prenatal genetics. We show how we are now routinely screening fetuses in the absence of two essential sorts of information. At the population level, we do not have sound, unbiased data about the prevalence, penetrance, and clinical variability of most mutations. At the level of the proband, it is often too soon to discern relevant information about the fetus’ phenotype. First, we outline the longstanding ethical objections to newborn screen [...]

by Verena Hofmann  , Céline Pagnotta  , Noémie Lacombe  and Myriam Squillaci

Received: 30 March 2023;  Published: 10 August 2023;  doi: 10.21926/obm.icm.2303033

Burnout is a syndrome commonly characterized by the three dimensions of Maslach and Leiter's model, namely emotional exhaustion, depersonalization, and lack of professional accomplishment. While burnout affects individuals in all professions, teachers are recognized as being at particular risk, a fact explained in the literature by the high level of relational demands inherent to the profession. During the pandemic and subsequently, these demands have even increased. Several studies have focused on the influence of [...]

by Emily Roberts  , Greg Clare  , Mahendran Balasubramanian  and Quinn Button

Received: 19 July 2022;  Published: 27 December 2023;  doi: 10.21926/obm.geriatr.2304264

The global population of adults 65 years of age and older will increase dramatically over the next several decades, presenting economic and social challenges requiring sustainable solutions. Aging is a process in which everyone is already involved, it is a lifelong experience not just a later life occurrence. Changing world demographics illustrate that people are living longer, among the world’s young people, survival to age 80 is expected to be commonplace. This new found “longevity dividend” needs to be maximized [...]

by Barbara Schmidt  , Teresa Deffner  and Jenny Rosendahl

Received: 11 December 2019;  Published: 28 April 2020;  doi: 10.21926/obm.icm.2002025

Patients in the intensive care unit are confronted with an extreme situation that may cause stress and anxiety. The negative experiences may cause patients to suffer for the long-term after leaving the intensive care unit. One such stressor in the intensive care unit is non-invasive ventilation. Positive therapeutic suggestions under hypnosis can help patients in intensive care to enhance their well-being by helping them to deal with specific stress like being ventilated. The aim of our study is to assess the effec [...]

by Maxwell Blazon  , Brianna LaCarubba  , Alexandra Bunda  , Natalie Czepiel  , Shayna Mallat  , Laura Londrigan  and Arturo Andrade

Received: 13 September 2020;  Published: 12 January 2021;  doi: 10.21926/obm.neurobiol.2101083

N-type (Cav2.2) calcium channels are key for action potential-evoked transmitter release in the peripheral and central nervous system. Previous studies have highlighted the functional relevance of N-type calcium channels at both the peripheral and central level. In the periphery, N-type calcium channels regulate nociceptive and sympathetic responses. At the central level, N-type calcium channels have been linked to aggression, hyperlocomotion, and anxiety. Among the areas of the brain that are involved in anxiety a [...]

by Jesse Tanko Zarmai  , Isaac Ibitoye Alabi  , Ebimene Ezekiel Ebisine  , Musa Tanko Zarmai  and Ovis D. Irefu

Received: 26 September 2023;  Published: 03 April 2024;  doi: 10.21926/jept.2402010

Inadequate electricity supply is a global challenge that needs solutions. This situation has compelled the purchasing of fossil fuel-generating units for use in residential, commercial, and industrial sectors to generate electricity. However, using fossil fuel generating units cause greenhouse gas emissions, bringing about environmental pollution and ultimately resulting in climate change. In particular, educational institutions require adequate and reliable power supply to ensure proper learning and teaching, whic [...]

by Mariella Di Stefano  , Sonia Baccetti  , Elio Rossi  , Maria Valeria Monechi  , Barbara Cucca  , Sergio Segantini  , Elisabetta Barbara Cortesi  , Fabio Voller  , Eleonora Fanti  , Alice Berti  and Stefano Bravi

Received: 27 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902029

Background: According to the international literature, users of Complementary Medicine (CM), Complementary and Alternative Medicine (CAM) and Complementary and Integrative Medicine (CIM) are physically more active, less overweight and have healthier lifestyles than the average Tuscan population. Aim: To evaluate the socio-demographic characteristics and lifestyles of patients of CM public clinics in the region of Tuscany and to define their profiles in terms of physical exercise, smoking habits, diet, intake of alc [...]

by Fabien Drault  , Youssef Snoussi  , Camila P. Palombo Ferraz  , Joelle Thuriot-Roukos  , Svetlana Heyte  , Ivaldo Itabaiana Junior  , Maya Marinova  , Sebastien Paul  and Robert Wojcieszak

Received: 25 October 2021;  Published: 13 January 2022;  doi: 10.21926/cr.2201001

Regardless of their size, supported gold nanoparticles are largely used for liquid-phase oxidation reactions. Small gold nanoparticles exhibit good performance during the reduction of organic compounds. The direct reduction of carboxylic acid to aldehyde is a famous and familiar reaction in the field of organic chemistry and is considered as one of the fundamental chemical transformations. Herein, we present Au/hydrotalcite, Au/MgO, and Au/Al2O3 systems as heterogeneous versatile catalysts to realize the oxidation [...]

by Clint Sutherland  and Beverly S. Chittoo

Received: 29 July 2024;  Published: 28 November 2024;  doi: 10.21926/aeer.2404024

Global efforts to develop low-cost solutions for the treatment of contaminants in wastewater continue unabated. The conversion of eggshells, a waste material, into a high-value product can be economical and environmentally sustainable. The recent developments in applying eggshells towards the biosorption of contaminants are presented. Eggshells effectively remove pollutants such as metal cations, metal anions, and reactive, basic, and direct dyes. Promising advances in modifying eggshells, elucidating the critical [...]

by Luiz Felipe da M. Rocha  , Leonardo C. Ferreira  , Maria de Fatima V. Marques  , Rodrigo S. Bitzer  and Marco Antônio Chaer Nascimento

Received: 18 May 2022;  Published: 06 July 2022;  doi: 10.21926/cr.2203020

We synthesized and spectroscopically characterized a new heterotrimetallic {Ti2Ni} ethylene (co)polymerization precatalyst containing one (α-diimine)NiBr2 and two (phenoxy-imine)TiCl4 scaffolds. Its calculated structure was investigated at the DFT B3LYP/LACVP** level. Our calculations showed that the titanium(IV) centers were in a slightly distorted trigonal bipyramidal environment, and the average Ti···Ni distance was 8.76 Å. The precatalyst was used for synthesizing polyethylene a [...]

by Zhen Liu  , Li Yang  , Abhishek Lahiri  , James F Rohan  and Frank Endres

Received: 26 December 2021;  Published: 27 March 2022;  doi: 10.21926/jept.2201010

Herein, we report the coating of nanostructured germanium using a polypyrrole (PPy) polymer coat as a composite anode material for the fabrication of lithium-ion batteries. The Ge/PPy composites were synthesized following the direct electrochemical deposition method in an ionic liquid (IL). The results revealed that the coating of PPy on Ge helped realize stable battery cycling and reversible capacities, which were not observed in uncoated Ge. The PPy layers could effectively inhibit side reactions between the elec [...]

by Simon Calles  , Paul Heitjans  and Alexander Börger

Received: 09 November 2021;  Published: 18 April 2022;  doi: 10.21926/jept.2202015

Prismatic PHEV2 form-factor lithium-ion cells with a nominal capacity of 25 Ah (as used for automotive applications) have been studied with electrochemical impedance spectroscopy (EIS). The data was evaluated using electrical equivalent circuits. Mathematical modeling, system identification, and the determination of model parameters of the lithium-ion cell were also carried out. While a study of the influence of temperature and state-of-charge (SOC) performed using pristine lithium-ion cells showed a nonlinear rela [...]

by Akash Dakhane  and Narayanan Neithalath

Received: 03 February 2022;  Published: 08 April 2022;  doi: 10.21926/rpm.2202006

The influence of different levels of alkalinity, expressed using M2O-to-binder ratio (n) and activator SiO2-to-M2O ratio (Ms), (M being the Na+ or K+ cation) on the reaction kinetics, compressive strength development and the reaction product formation in slag-based systems activated using alkali powders are discussed. The fundamental idea is to better understand one-part, “just-add-water” type alkali activated binders that are easy-to-use than the systems that rely on liquid activators. The difference in the behavi [...]

by Andrew Williams  and Murray Thomson

Received: 09 November 2022;  Published: 09 January 2023;  doi: 10.21926/jept.2301003

This paper examines the economic case for the UK to proceed urgently with the installation of thermal insulation and heat pumps in most UK buildings, in the context of the legal requirement to achieve net-zero carbon emissions by 2050. A recent study by the same authors assumed that such insulation and heat pumps would be in place, and showed how the whole of the UK’s energy demand could be met by low carbon electricity generation and appropriate storage. This paper extends the modelling to consider the risk that i [...]

by Jessie Poquérusse  and Bryan W. Luikart

Received: 10 April 2017;  Published: 24 April 2017;  doi: 10.21926/obm.neurobiol.1702004

Large-scale genetic sequencing studies have identified a wealth of genes in which mutations are associated with autism spectrum disorder (ASD). Understanding the biological function of these genes sheds light onto the neurodevelopmental basis of ASD. To this end, we defined functional categories representing brain development – (1) Cell Division and Survival, (2) Cell Migration and Differentiation, (3) Neuronal Morphological Elaboration, (4) Development and Regulation of Cellular Excitability, and (5) Synapse Forma [...]

by Sarah Long  , Roanna Lobo  , Peter O'Leary  and Jan E. Dickinson

Received: 07 September 2021;  Published: 03 November 2021;  doi: 10.21926/obm.genet.2104142

Non-invasive prenatal testing (NIPT) for a panel of 25 single gene disorders became available in Western Australia in 2020 and potentially may be able to test for panels of hundreds of disorders as is the case with reproductive carrier screening. How this information would be used by parents in a population screening model is unknown. We used a phenomenological approach to explore retrospectively whether mothers of children with single gene or chromosomal disorders would have wanted to know about their child’ [...]

by Jamylle Yanka Cruz Ribeiro  , Ronaldo Santos da Silva  , Giancarlo Richard Salazar-Banda  and Katlin Ivon Barrios Eguiluz

Received: 06 September 2022;  Published: 19 January 2023;  doi: 10.21926/cr.2301005

This paper describes the synthesis of Pd0.70-Nix-By nanoparticles (x:y = 0.30:0, 0:0.30, 0.25:0.05, 0.20:0.10, 0.15:0.15, and 0.10:0.20) supported on carbon Vulcan XC-72 R by the chemical reduction method using ethylene glycol as a reducing agent for the study of the electrochemical oxidation of ethanol in alkaline media. Neither surfactants nor templates were used during the syntheses. The catalysts were physically characterized by transmission electron microscopy that showed the formation of nanoparticles with di [...]

by Jacqueline Lamond  and Charles L. Shapiro

Received: 07 December 2020;  Published: 05 July 2021;  doi: 10.21926/obm.geriatr.2103173

Breast cancer and osteoporosis are both diseases of aging. The "one in eight" lifetime risks of breast cancer occur primarily in the sixth, seventh, eighth, and ninth decades of life. One-third of postmenopausal women will experience an osteoporotic fracture. It is the coalescence of osteoporosis, breast cancer, and breast cancer treatments that, in some cases, increases the risks of osteoporotic fracture. That makes it imperative to assess risk factors, screen, and prevent or treat osteoporosis in postmenopausal w [...]

by Anjali Singh  , Kashish Ujla  and Smriti Shrivastava

Received: 25 January 2025;  Published: 19 June 2025;  doi: 10.21926/cr.2502004

Lignocelluloses are complex plant polysaccharides made of lignin, cellulose, and hemicellulose, and products made from these components find immense market potential. They can be effectively valorized to products related to bioenergy, bioplastics, food and nutrition, medication delivery systems, and other elements. Significant sources of lignocellulosic biomass include sugarcane bagasse, corn cob, rice straw, potato haulms, cocoa pods, etc. Enzyme-based valorization processes find immense potential, as they are eco [...]

by Andrew Weems  , Wenyan Li  , Duncan Maitland  and Luz Marina Calle

Received: 12 September 2019;  Published: 31 December 2019;  doi: 10.21926/rpm.1904008

Biomedical applications of shape memory polymers (SMPs) are limited by their biostability, degradability, and possible toxicity risks after implantation. Mesoporous silica nanoparticles (MSNs) were used to increase the oxidative biostability (increase time until degradation occurs) using antioxidants and to induce oxidative degradation through incorporation of hydrogen peroxide-containing MSNs with modified surfaces. The presented results confirm increased oxidative stability using antioxidants, and alternatively, [...]

by David J Tansey  and Carel W Le Roux

Received: 12 October 2020;  Published: 17 May 2021;  doi: 10.21926/obm.icm.2102017

Oesophageal cancer is the ninth most common cancer and the sixth most common cause of cancer deaths worldwide [1]. Over the past number of years, due to earlier diagnosis and better treatment, we are seeing improvements in the survival rates of oesophageal cancer, with more patients living longer post-esophagectomy surgery. Unintentional weight loss is a common unintended feature seen in patients post-esophagectomy done with curative intent. Many recent studies have demonstrated the links between the pathophysiolog [...]

by Max F. Platzer  and Nesrin Sarigul-Klijn

Received: 28 January 2020;  Published: 29 April 2020;  doi: 10.21926/jept.2002005

The current status of a project is described which aims to demonstrate the technical and economic feasibility of converting the vast wind energy available over the globe’s oceans and lakes into storable energy. To this end, autonomous high-performance sailing ships are equipped with hydrokinetic turbines whose output is stored either in electric batteries or is fed into electrolysers to produce hydrogen which then is compressed and stored in tanks. In the present paper, the previous analytical studies which showed [...]

by Muayad Alali  , Michael Z. David  , Sandra A. Ham  , Danziger-Isakov LA  , Allison H. Bartlett  , Lindsay Petty  and Jennifer C. Pisano

Received: 27 November 2019;  Published: 21 February 2020;  doi: 10.21926/obm.transplant.2001102

Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers resolve more rapidly. Retrospective medical record review was performed for all cancer patients with febrile neutropenia (FN) in the pediatric oncology unit at University of Chicago Medicine Comer Children’s Hospital f [...]

by Marta Evelia Aparicio-García  and Roberto Andrés Lasso Báez

Received: 06 November 2023;  Published: 27 February 2024;  doi: 10.21926/obm.geriatr.2401271

Older trans people have been largely unaddressed both in the context of the LGBTIQ+ community and in studies on geriatrics and aging. This literature review compiles up-to-date information on transgender elders, providing a summary of the Spanish historical context in which trans people have been raised, and analyzes the areas in which to center possible courses of action and research on a global scale. The themes tackled are the presence of victimization and violence; the effects of medical transition, taking into [...]

by Masoume M. Raeissi  and Rob Knapen

Received: 07 April 2025;  Published: 12 August 2025;  doi: 10.21926/aeer.2503028

Environmental science addresses critical global challenges, including climate change, biodiversity loss, and sustainability. These complex topics generate a vast amount of both structured and unstructured data, from remote sensing output to policy documents, guidelines, and scientific literature. Effectively processing and utilizing this information is essential for advancing research and supporting decision-making. Large Language Models (LLMs) have shown remarkable capabilities in natural language understanding an [...]

by Alberto Arias-Pérez  , Daniel Ramírez-Torres  , María E. Rodríguez  , Silvia Portela-Bens  , Emilio García-Suarez  , Manuel A. Merlo  , Aglaya García-Angulo  , Ismael Cross  , Thomas Liehr  and Laureana Rebordinos

Received: 31 July 2018;  Published: 24 October 2018;  doi: 10.21926/obm.genet.1804044

Background: MicroRNAs (miRNAs) are small, non-coding RNAs that play a very important role in gene expression by regulating mRNA cleavage and translation. The Senegalese sole, Solea senegalensis (Kaup 1858), is a flatfish species that shows great potential for marine aquaculture. Nevertheless, the existence of sexual dysfunction of males reared in captivity, high larval mortality, and diseases have hampered its production. The integration of sequence information with data on chromosomal physical location is useful f [...]

by Camila Sandoval  , Colleen A Lambo  and Michael Carey Satterfield

Received: 01 June 2018;  Published: 28 December 2018;  doi: 10.21926/obm.genet.1804058

Understanding the pathophysiology of disease can be an essential step to determining where and how to intervene for preventive or corrective health. Intrauterine growth restriction (IUGR) has been defined in livestock species as impaired gestational development of a fetus or its parts [1]. This broad category of ailments described by low fetal weight is accompanied by susceptibility to adult onset of chronic disease through fetal programming of numerous organ systems and their functions. This concern affects humans [...]

by Arnaud Philippot  , Yannick Bleyenheuft  and Anne De Volder

Received: 21 June 2020;  Published: 07 January 2021;  doi: 10.21926/obm.icm.2101002

In a previous study conducted to assess the impact of physical exercise on the symptoms of depression and anxiety in preadolescents in the school environment, which included a subgroup of participants comprising eleven randomly selected teens (aged 9–11) and all enrolled in primary education, it was immediately observed that one participant referred to as Andy was being bullied and teased, and the teachers were completely unaware of this scenario. All the participants of the study were volunteers, and were subjecte [...]

by Tara T. Lineweaver  , Suneeta Kercood  , Elyse B. Morgan  , Shelby L. Rampone  , Colleen C. Frank  , Scott A. McLuckie  and Mack F. Reed

Received: 27 October 2019;  Published: 07 January 2020;  doi: 10.21926/obm.icm.2001002

Past research suggests that exercise is associated with improved working memory (WM) abilities, and that athletes have better executive functioning and WM skills than non-athletes. However, no studies to date have separated the effects of exercise from the effects of athletic participation when examining WM. This study had three primary goals: (1) to determine whether amateur college athletes have better auditory and visual WM than their non-athlete peers who exercise frequently and whether non-athlete frequent exe [...]

by Gerhard Litscher

Received: 11 November 2020;  Published: 13 November 2020;  doi: 10.21926/obm.icm.2004043

The Nogier reflex or reflex auriculo-cardiac (RAC) or the dynamic pulse reaction is a physiological phenomenon that is not generally accepted in conventional medicine. Therefore, evidence-based research in this sub-area is important for auricular medicine as it provides appropriate scientific evidence for better acceptance. In this editorial, a RAC measurement based on a modified smartphone registration and analysis is presented. The contribution is intended to stimulate researchers to continue working in this inte [...]

by Antonella Ciaramella

Received: 01 January 2020;  Published: 17 March 2020;  doi: 10.21926/obm.icm.2001014

Over the last 30 years, several neuroimaging and neurophysiological experiments have lent support to the neuropsychology of consciousness, and several definitions have followed to describe it. The phenomenological perspective of consciousness facilitates the description of the individual’s awareness experience of internal states (e.g., perception, sensations, emotion, volition, or memories), thus helping us to better understand the relationship between the brain and mind. Although significant research has been aime [...]

by Nicholas Lim  , Gregory Beilman  and Timothy Pruett

Received: 21 March 2018;  Published: 12 June 2018;  doi: 10.21926/obm.transplant.1802011

Portal hypertension often occurs transiently with injection of islet cells into the portal system during total pancreatectomy-islet autotransplantation (TPIAT). We describe a TPIAT patient with non-cirrhotic portal hypertension (NCPH) two years after surgery initially identified with esophageal varices on upper endoscopy. The underlying mechanism for the development of NCPH after TPIAT is unclear but infectious and immune-related pathways have been proposed. Management of NCPH is primarily treatment of complication [...]

by Elham Amjad  , Babak Sokouti  , Solmaz Asnaashari  and Siavoush Dastmalchi

Received: 29 August 2024;  Published: 17 December 2024;  doi: 10.21926/obm.genet.2404275

This systematic review examines the role of SnRK2 (Sucrose non-fermenting 1-Related protein Kinase 2) genes in Arabidopsis thaliana growth and responses to abiotic stresses. SnRK2 protein kinases are key components of abscisic acid (ABA) signaling and osmotic stress responses in plants. The review synthesizes findings from numerous studies on how different SnRK2 genes regulate Arabidopsis growth, development, and stress tolerance at various life stages. Key topics covered include SnRK2 functions under environmental [...]

by Maud Gits-Muselli  , Stéphane Bretagne  and Alexandre Alanio

Received: 04 December 2018;  Published: 17 January 2019;  doi: 10.21926/obm.genet.1901060

Pneumocystis jirovecii is an atypical fungus transmitted via the airborne route between humans. This fungus is exclusively associated with humans and almost each individual has encountered it at least once before reaching the age of two. P. jirovecii can be cleared and spontaneously resolutive in immunocompetent, whereas it can be responsible for severe Pneumocystis pneumonia (PCP) in immunocompromised patients. In the next decades, the putative increase of the population of immunocompromised patients is likely to [...]

by Joep Geraedts

Received: 08 April 2019;  Published: 14 August 2019;  doi: 10.21926/obm.genet.1903089

Mitochondrial diseases are among the most prevalent inborn errors of metabolism. The overwhelming majority of mitochondrial diseases (about 85%) result from mutations in nuclear genes involved in oxidative phosphorylation, while some (15%) are caused by mutations in mitochondrial DNA (MtDNA). The familial mtDNA mutations are exclusively inherited from the mother. There are four main methods available to prevent the transmission of mtDNA mutations: preimplantation genetic diagnosis (PGD) or prenatal diagnosis (PND) [...]

by Em V. Adams  , Marieke Van Puymbroeck  , Heather S. Torphy  , Brian C. Helsel  , Karen A. Kemper  , Cheryl Dye  and Arlene A. Schmid

Received: 03 October 2019;  Published: 03 January 2020;  doi: 10.21926/obm.geriatr.2001097

Falls have negative consequences for older adults, but falls can be reduced through interventions that target the reduction of fall risk factors. Cognitive behavioral education programs and therapeutic yoga are two interventions that have independently been used as a means to reduce the risk of falls. The purpose of this study was to determine if adding therapeutic yoga following an education intervention improved well known fall risk factors. Potential participants were recruited through a senior center for a 12-w [...]

by Ahmed H Abdelhafiz

Received: 05 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002113

The prevalence of diabetes in older people is increasing. Diabetes in old age is associated with increased risk of mental dysfunction. Cognitive dysfunction and mood disorders such as depression, anxiety and diabetes-related distress tend to coexist in older people with diabetes and appear to have bidirectional relationship acting as a risk factor and, at the same time, as a consequence of diabetes. To break the vicious circle of this complex reciprocal relationship between diabetes and mental dysfunction, early id [...]

by Ryan Sweeney  , Alvaro J La Rosa  , Nina Sheade  , Rachael C. Olson-Marszewski  , Ryan Bergren  and Edwin Meresh

Received: 12 January 2020;  Published: 01 April 2020;  doi: 10.21926/obm.neurobiol.2002054

Case studies have associated catatonia with withdrawal from benzodiazepines and clozapine, both of which have been shown to increase GABA activity. Long-term use of GABAergic medications could result in GABAA downregulation and sudden discontinuation of the GABAergic drug could lead to a GABA hypoactive state which could predispose the patient to catatonia. The anticonvulsant topiramate, is known to increase brain GABA activity. Prader-Willi syndrome (PWS) is a genetic imprinting disorder characterized by lack of e [...]

by Konstantinos Magganas  , Sophia Delicou  , Aikaterini Xydaki  and Zoi Pallantza

Received: 19 May 2019;  Published: 17 September 2019;  doi: 10.21926/obm.genet.1903095

Thalassemia syndromes are a group of hemoglobinopathies characterized by gene defects that disrupt normal hemoglobin production. Thalassemia intermedia (TI) is referred to as a group of disorders with a less severe form of the disease compared to thalassemia major. We present a case of a 60-year-old woman who was referred to a hematologist for chronic anemia and splenomegaly.

by Mônica Batista Leite  and Paulo Roberto Lopes Lima

Received: 07 March 2021;  Published: 28 July 2021;  doi: 10.21926/rpm.2103032

The production of concrete using recycled aggregates, obtained from the processing of construction and demolition waste, is extensively practiced worldwide. However, the effect of simultaneous adding fine recycled aggregate and the recycled coarse aggregate on the mechanical properties of concrete is still unfamiliar. This work aims to evaluate the influence of the water/cement ratio (WC Ratio), the fine recycled aggregate content (%FRA), the coarse recycled aggregate content (%CRA), as well as the interaction betw [...]

by Kristopher M. Struckmeyer  , Alex J. Bishop  , Brenda J. Smith  and Brandt C. Gardner

Received: 27 August 2018;  Published: 27 February 2019;  doi: 10.21926/obm.geriatr.1901037

Background: The purpose of this study was to examine discrepancies in self-proxy agreement of biopsychosocial factors and the influence of objective well-being and psychosocial resources self and proxy appraisals of subjective well-being in older adults. Methods: Seventy-two older adult-proxy dyads rated the biopsychosocial health of non-cognitively impaired older adults. Results: Proxies underestimated functional ability, psychosocial factors, and overrated negative health outcomes compared to older adults. Older [...]

by Jeffrey M. Witkin  , Lalit K. Golani  , Rok Cerne  , Md. Toufiqur Rahman  , Guanguan Li  , Michael M. Poe  , James M. Cook  and Jodi L. Smith

Received: 05 May 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903073

Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of α5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also [...]

by Joachim Andrassy  and Antje Habicht

Received: 05 November 2018;  Published: 27 June 2019;  doi: 10.21926/obm.transplant.1902070

In recent years, the potential of hematopoietic stem cells, regulatory T-cells, and mesenchymal stem cells have brought about a variety of clinical tolerance trials. Every approach has yielded promising results; however, the riddle of transplant tolerance has not been solved as of yet. The results of the ongoing trials in this field will provide additional information regarding the risks and benefits of these therapy approaches.

by Plamen Mihaylov  , Burcin Ekser  , Daiki Soma  , Andrew Lutz  , Jonathan Fridell  and Chandrashekhar A. Kubal

Received: 04 January 2021;  Published: 11 March 2021;  doi: 10.21926/obm.transplant.2101138

One of the most feared complications in liver transplantation is hepatic arterial thrombosis (HAT). The incidence of HAT in liver transplantation varies from 1.2% and 8%. One of the risk factors for this complication is anatomical complexity of hepatic arterial system. The focus of this short communication is to show our approach in dealing with aberrant left hepatic artery in settings of liver transplantation. This is a single center experience. Between January 2016 and June 2019, we procured and transplanted 357 [...]

by Lotte Hvas

Received: 28 August 2023;  Published: 30 October 2023;  doi: 10.21926/obm.geriatr.2304256

Narratives and how women interpret their symptoms have always been a part of how menopause is experienced. Today, as women feel more accessible to talk about menopause, new narratives are being formed and negotiated - both to menopause and concerning women becoming older. These different narratives mirror the fact that the transitional phase differs from woman to woman and that some women experience many symptoms while others do not seem bothered at all. Some narratives underscore menopause as a transformative peri [...]

by Lin Xie  and Donald Kirk

Received: 09 June 2021;  Published: 16 September 2021;  doi: 10.21926/cr.2103003

Fe-rich alloys have been widely studied as catalyst materials for the cathodic oxygen reduction reaction (ORR) in hydrogen fuel cells, and many have shown high activities. The stability of Fe-rich catalysts has also been researched, and some studies have shown promising results using an accelerated stress test (AST), which uses a potential cycling method. However, for commercial fuel cell applications, such as standby power systems, the catalyst has to tolerate a high potential for a long period, which can not be r [...]

by Marco Barale  , Ruth Rossetto Giaccherino  , Ezio Ghigo  and Massimo Procopio

Received: 31 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.geriatr.1901033

Background: It is well known that hypovitaminosis D has been associated with various cardio-metabolic disorders, though the pathogenetic link, if any, still remains unclear. Our aim was to evaluate in elderly uncontrolled non-insulin-treated type 2 diabetic patients with hypovitaminosis D, whether six-months vitamin D supplementation was able to improve glycemic control, lipid profile and blood pressure levels. Methods: In an open-label pilot study, thirty type 2 diabetic patients (age 71.5 ± 3.2 years, BMI [...]

by Ganga R. Neupane  , Amrit Kaphle  , David N. Mcllroy  , Elena Echeverria  , Prasanna Sankaran  and Parameswar Hari

Received: 12 May 2021;  Published: 04 August 2021;  doi: 10.21926/jept.2103035

Iron doped ZnO (Fe-ZnO) nanoparticles were synthesized using two techniques that are economical as well as scalable to yield tunable properties of nanoparticles for facilitating down conversion in an absorbing layer of a solar cell. To evaluate the suitability of Fe-ZnO nanoparticles prepared by two deposition methods, we present a comparison of optical, electrical, and structural properties of Fe-ZnO using several experimental techniques. Structural properties were analyzed using transmission electron microscopy a [...]