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Open Access Original Research

Genes Coding for GPI Biosynthesis in Pneumocystis Experienced Relaxed Selection: A Follow-up Study

Received: 05 May 2019;  Published: 11 July 2019;  doi: 10.21926/obm.genet.1903083

Abstract

Background: Phylogenetic analysis shows that Pneumocystis have coevolved with their mammalian hosts for millions of years. As a result, infection by Pneumocystis is species specific (i.e. a given Pneumocystis species can infect only a single species of host). This specificity suggests the existence of a Red-Queen dynamic between Pneumocystis and its host. Evidence of this dynamic is provided by the molecular diversity and the elevated rate of non-synonymous versus synonymous (dN/dS) codon substitutions among Pneumo [...]

2015 11504

Open Access Original Research

Effect of Fiber/Matrix Interface Modification on Basalt Fiber Reinforced Geopolymer Composites

Received: 22 December 2020;  Published: 29 March 2021;  doi: 10.21926/rpm.2101008

Abstract

Continuous fiber reinforced geopolymer matrix composites offer the potential for use in structural applications at temperatures up to 700°C, while enabling the manufacture at temperatures below 100°C. Studies have investigated a variety of high temperature structural fiber reinforcements, including carbon, SiC and Al2O3. While there has been active research into various grades of Al2O3 fibers, SiC is most commonly used for high temperature reinforcement of geopolymers in oxidizing environments. Both familie [...]

2041 11494

Open Access Review

Mechanisms of Origin and Clinical Effects of Multiple Small Supernumerary Marker Chromosomes, Each Derived from a Different Chromosome

Received: 15 November 2016;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701002

Abstract

Small supernumerary marker chromosomes (sSMCs) are centric chromosome fragments additionally present in an otherwise normal human chromosome set that cannot be characterized by classical cytogenetic techniques alone. The majority of sSMCs are not yet related to a defined clinical phenotype. We compiled from the literature all 78 cases with multiple sSMCs per cell in which the chromosomal origin of the sSMCs has been identified. The number of sSMCs varies from 2 to 7; 64% have 2 sSMCs, 14% have 3 sSMCs, and the freq [...]

1792 11493

Open Access Case Report

Candida auris and Heart Transplantation. Preoperative Attitude.

Received: 15 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.transplant.1901053

Abstract

In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multidrug-resistant yeast that is associated with serious infections and with a mortality rate that can reach 70%. This problem is especially serious in transplant recipients receiving intense immunosupressive therapy. There are no established criteria on the relevance of this colonization or on when the transplant should be contraindicated in these cases. Five cases of colonization and two of candidemia have been [...]

1802 11492

Open Access Concept Paper

Enhancing Biodiversity Education and Outreach for Conservation Awareness and Environmental Stewardship

Received: 15 August 2024;  Published: 02 April 2025;  doi: 10.21926/aeer.2502016

Abstract

Biodiversity—the rich variety of life on Earth—is essential for ecosystem stability and resilience, which, in turn, supports human well-being. However, human activities, such as habitat destruction, pollution, overexploitation, and climate change, are placing unprecedented pressures on global biodiversity, emphasizing the need for urgent conservation measures. In response, biodiversity education and outreach initiatives have become pivotal in fostering conservation awareness and action. This paper critically evalua [...]

1882 11487

Open Access Original Research

Role of Activity Professionals in Applying APIE Model to Enhance Residents’ Activity and Engagement in Long-Term Care Settings

Received: 23 August 2022;  Published: 25 June 2023;  doi: 10.21926/obm.geriatr.2302239

Abstract

Residents’ activity is a strong contributor to the quality of life in long-term care facilities. Hence, activity professionals have an essential role to play in enhancing residents’ activity engagement. Professional practice model for activity professionals includes Assessment, Planning, Implementation, and Evaluation (APIE model). Although activity professionals have made advances in demonstrating their value, few studies have focused on the APIE model for activity professionals in long-term care facilities. A sur [...]

1445 11483

Open Access Review

Bacterial Infections after Liver Transplantation: Updates in Post-Surgical Infections, Vancomycin-Resistant Enterococcus, and Multi-Drug Resistant Enterobacteriaceae

Received: 29 March 2018;  Published: 02 November 2018;  doi: 10.21926/obm.transplant.1804023

Abstract

Liver transplantation is a life-saving procedure available worldwide. Despite advances in its surgical and immunosuppressive strategies, infectious complications carry significant morbidity and mortality. Bacterial infections are the most common infective etiologies, and the majority are seen during the first four weeks post liver transplantation. Infectious complications are often intra-abdominal in origin, such as biliary complications and abdominal abscesses. Infections due to multi-drug resistant organisms are [...]

1478 11482

Open Access Review

Application of Microfluidic Biochips for Human Islet Transplantation

Received: 08 November 2018;  Published: 21 December 2018;  doi: 10.21926/obm.transplant.1804034

Abstract

In this review, we discuss the application of microfluidic devices in studying the physiology and pathophysiology of human islets and beta-cells, especially its application for human islet transplantation. Human islet transplantation is a promising therapy for Type I diabetes; however, the islet transplant outcomes for achieving complete insulin independence are far from perfect and face many challenges. This review focuses on the microfluidic devices developed in our laboratory, which can address these challenges [...]

1675 11480

Open Access Original Research

New Electrocatalysts Prepared by Co-Sputter Deposition for the Direct Oxidation of Methanol

Received: 25 May 2021;  Published: 13 August 2021;  doi: 10.21926/jept.2103038

Abstract

Direct methanol oxidation catalysts Pt1-x-Tax (0

1801 11475

Open Access Review

Aging High: Opioid Use Disorder in the Elderly Population

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

Abstract

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

1731 11474

Open Access Original Research

Social Engagement and Task Complexity: Physical Activity Characteristics and Executive Function Among Older Adults

Received: 15 May 2019;  Published: 27 November 2019;  doi: 10.21926/obm.icm.1904064

Abstract

Physical activity participation has been found to favorably influence cognitive function across the lifespan. Specific characteristics, or qualities, of physical activity involvement (e.g., type, intensity, level of cognitive demand) may yield particular benefits. The purpose of this study was two-fold. The first objective was to develop taxonomies for two physical activity characteristics of interest: the level of task complexity (motoric and cognitive) and the level of social engagement. The second objective was [...]

1865 11468

Open Access Review

A Tale of Two Flaviviruses: West Nile Virus and Zika Virus in Solid Organ Transplantation

Received: 02 November 2018;  Published: 08 January 2019;  doi: 10.21926/obm.transplant.1901038

Abstract

Flaviviruses can cause epidemics and endemics with substantial public health threat and economic impacts. In the last few decades, many flaviviruses have re-emerged or expanded their territories to new regions or continents, including West Nile virus (WNV) which has become endemic in the US since its arrival in 1999 and Zika virus (ZIKV) which recently spread across the Americas. These events demonstrate the speed with which a vector-borne pathogen can disseminate when introduced into a susceptible population with [...]

1924 11458

Open Access Research Article

Enzymatic Hydrolysis of Meat Waste for a Circular Economy

Received: 30 December 2022;  Published: 16 February 2023;  doi: 10.21926/cr.2301008

Abstract

This work demonstrates the possibility of implementing a technology that allows profitable value to be drawn from the meat waste from retail stores. Protein hydrolysate, collagen and fatty acids were recovered from meat waste through enzymatic hydrolysis using a mixture of enzymes: a protease (Alcalase) and a lipase (Resinase). Enzymatic hydrolysis was studied by response surface methodology (RMS). Four independent variables were used to study the response variables. The analysis showed that all factors including p [...]

1750 11452

Open Access Review

RNA Editors and DNA Mutators: Cancer Heterogeneity Through Sequence Diversification

Received: 03 December 2018;  Published: 08 April 2019;  doi: 10.21926/obm.genet.1902072

Abstract

Cancer development and progression is strongly associated with somatic mutations. From oncogenic hits that initiate the primary tumor formation to metastasis, the tumor mutational burden (TMB) plays a prominent role in the disease progression for the vast majority of cancer types. Not only are heterogeneous mutational loads or genetic heterogeneity causal to transcriptomic and proteomic discrepancies and to phenotypic diversity between individuals, they are also between tumor cells. But in addition to mutations, a [...]

1720 11449

Open Access Original Research

Theoretical Modelling of Liquid Crystal Electro-Optical Material Display Elements to Achieve Optimal Low Power Consumption Ship Stealth

Received: 29 December 2020;  Published: 14 May 2021;  doi: 10.21926/rpm.2102019

Abstract

Advanced optical stealth techniques are of growing importance in the role of manned and unmanned aircraft or ship platforms. We consider here the concept of using passive reflective display elements rather than high power active light projection to achieve a low observable camouflaged ship platform. This paper presents practical consideration towards minimal radiated power user-driven requirements using adaptive liquid crystal electro-optical methods. Optical reflectivity for a multi-layer liquid crystal cell struc [...]

1923 11445

Open Access Review

Krabbe Disease–To Add or Not to Newborn Screening?

Received: 07 September 2023;  Published: 12 January 2024;  doi: 10.21926/obm.genet.2401210

Abstract

Krabbe disease (KD), a severe neurodegenerative disorder, has been controversial in the space of newborn screening (NBS) in the United States. Families continue to advocate for the addition of KD to the Recommended Uniform Screening Panel (RUSP) after being declined for the second time in February 2023. Even with significant progress in KD screening tests, uncertainty about the phenotypic presentations, and effectiveness of hematopoietic stem cell transplant (HSCT) seems to have impeded the addition of this conditi [...]

1431 11440

Open Access Original Research

The Impact of Operating Conditions on the Performance of a CH4 Dry Reforming Membrane Reactor for H2 Production

Received: 25 March 2020;  Published: 14 May 2020;  doi: 10.21926/jept.2002008

Abstract

Biogas is a promising resource for the production of H2 since it liberates energy by recycling waste, along with the reduction of CO2. In this paper, the biogas dry reforming membrane reactor is proposed to produce H2 for use in fuel cells. Pd/Cu alloy membrane is used to enhance the performance of the biogas dry reforming reactor. This study aims at understanding the effect of operating parameters such as feed ratio of sweep gas, pressure in the reactor, and reaction temperature on the performance of the biogas dr [...]

1964 11440

Open Access Review

Prevalence of Post-Traumatic Stress Disorder in General Population During COVID-19 Pandemic: An Umbrella Review and Meta-Analysis

Received: 31 May 2023;  Published: 21 July 2023;  doi: 10.21926/obm.neurobiol.2303175

Abstract

During the COVID-19 pandemic, global populations have experienced quarantine and lockdown restrictions, adversely affecting individuals' psychological well-being. This comprehensive review aims to estimate the prevalence of Post-traumatic Stress Disorder (PTSD) within the general population amidst the COVID-19 pandemic. Employing the PRISMA guideline, the databases PubMed/Medline, Science Direct, Web of Science, Cochrane and Google Scholar were used in the data extraction process, and publications from December [...]

1325 11439

Open Access Original Research

The Effect of Curing Temperature on the Morphology and Electro-Optical Properties of a Flexible UV-Cured Polymer Dispersed Liquid Crystal (PDLC)

Received: 11 October 2020;  Published: 08 December 2020;  doi: 10.21926/rpm.2004023

Abstract

In this work, the experimental data on flexible PDLC films at the industrial scale and the effect of cure temperature (Tc) on the morphology and electro-optical properties of a UV-cured PDLC system via polymer-induced phase separation (PIPS) method were studied. Under constant UV radiation intebsity and thickness, the morphological parameters such as dimension, number density, and volume fraction of the phase-separated liquid crystal droplets as well as the optical transmissions and switching voltages as a function [...]

1891 11439

Open Access Original Research

A Simplified Optimization Model for Sizing Proton-Exchange Membrane Fuel Cells

Received: 03 June 2020;  Published: 24 July 2020;  doi: 10.21926/jept.2003011

Abstract

The fluctuations in the cost of energy coupled with the gradual decrease in natural resources (i.e., oil, natural gas, coal) and the environmental issues caused by the extensive use of fossil fuels, demand the urgent need for the development of advanced and clean energy systems. The European Union has requested new measures to target climate and energy deterioration by developing renewable energy sources by 2030. The stochastic character of the energy sources and the fluctuation in demand for the energy systems pos [...]

2104 11437

Open Access Original Research

Wind-Stress Variations from Deep to Shallow Water during Hurricanes for Air-Sea-Land Interaction Applications

Received: 27 December 2021;  Published: 14 February 2022;  doi: 10.21926/aeer.2201006

Abstract

In September 2020 Hurricane Sally impacted two National Data Buoy Center (www.ndbc.noaa.gov) buoys near its track: 42040 in the deep water and 42012 in the shallow. Using pertinent air-sea interaction formulas from the literature, analyses of these buoy data indicate that, under fully rough airflow and wind sea conditions, U* = a Hs2 /Tp3 + b, here U* is the friction velocity, Hs is the significant wave height, and Tp is the peak wave period. It is found that a = 28 and b = 0.12 for the deep water environment, a = [...]

1390 11436

Open Access Original Research

Barley and Malt as Base Ingredients for the Production of New Bio-Functional Foods

Received: 14 April 2023;  Published: 19 September 2023;  doi: 10.21926/rpn.2303018

Abstract

This work aimed to evaluate the chemical composition, bioactive compounds (phenolics and γ-aminobutyric acid, GABA), and antioxidant properties of different barley varieties (Overture, Charles, Sinfonía, Montoya, and Andreia) and their malts to weigh up them as potential ingredients for producing new bio-functional foods. For this, five barleys and five malts obtained from them were studied. Regarding chemical composition, total starch was the main component (≈62%) of barleys followed by total di [...]

1624 11424

Open Access Research Article

Feasibility of Implementing Therapeutic Yoga in Assisted Living Facilities

Received: 19 August 2020;  Published: 04 January 2021;  doi: 10.21926/obm.geriatr.2101148

Abstract

The purpose of this convergent mixed methods study was to explore the feasibility of implementing a chair yoga intervention in assisted living facilities (ALFs), evaluating reach, demand, acceptability, practicality, treatment fidelity, and safety. A yoga intervention was implemented twice a week for eight weeks at four different ALFs. Feasibility data were collected in the form of observational data, reflective field notes, and focus groups. Quantitative and qualitative data strands were compared to determine if r [...]

2056 11421

Open Access Research Article

Wave Propagation and Scattering due to Debonding in CFRP Strengthened Reinforced Concrete Beams

Received: 28 May 2020;  Published: 27 August 2020;  doi: 10.21926/rpm.2003020

Abstract

Carbon fibre reinforced polymer (CFRP) systems as sheets or plates are commonly used to strengthen and retrofit damaged reinforced concrete beams. In general, the bond between the FRP element and concrete defines the effectiveness of the externally bonded FRP materials. In most cases, the interface bonding behaviour is usually tested via static loading conditions. In this paper, the bonding is verified under dynamic conditions. Wave propagation is modelled in delaminated CFRP strengthened reinforced concrete beam. [...]

2000 11392

Open Access Research Article

Electrodermal Correlates of Hypnosis: Current Developments

Received: 07 February 2020;  Published: 01 April 2020;  doi: 10.21926/obm.icm.2002017

Abstract

Hypnosis has proven to be an effective treatment in disorders that affect the autonomic nervous system (ANS). However, the studies investigating the nature of its effect on the ANS have reported contradictory results. Measurement of electrodermal activity (EDA) is an objective way to assess the activity of the sympathetic branch of the ANS. We aim to elucidate the effects of hypnosis on EDA. Here, we report the results of two studies, both investigating the psychophysiological effects of hypnosis.In the first exper [...]

1870 11386

Open Access Review

Prospects for Cure in Wilson Disease

Received: 18 July 2018;  Published: 22 August 2018;  doi: 10.21926/obm.genet.1803030

Abstract

Wilson Disease is a monogenetic disorder of copper metabolism affecting the ATP7B gene. Treatment is lifelong and focuses on removal of copper to arrest disease progression and improve the clinical manifestations of copper toxicity. Currently the only cure is liver transplantation, however, lifelong monitoring and immunosuppressive medications are still needed afterwards. The possibility of introducing functional ATP7B gene through gene therapy provides an exciting potential option for achieving a more permanent cu [...]

1847 11385

Open Access Review

Scientific Evidence in Homeopathy: A Dynamic Database

Received: 27 April 2021;  Published: 28 September 2021;  doi: 10.21926/obm.icm.2103032

Abstract

Homeopathy, a system of Traditional and Complementary Medicine (T&CM, according to WHO definition), is under frequent attack by skeptics because of its supposed “lack of evidence.” To overcome the distrust of skeptics and the public, many databases have been created, which focused on collecting all the published and indexed studies; however, none of these seem to be “comprehensive” and systematic enough. Therefore, this study aimed to evaluate the most reliable and available homeopathic studies in order to systemat [...]

1341 11383

Open Access Research Article

Effects of Chemical Stabilisation of Eggshells-Lime and Fly-Ash-Cement on the Structural Strength of Subgrade Soil in Rural Roads

Received: 15 May 2022;  Published: 04 August 2022;  doi: 10.21926/rpm.2203013

Abstract

This study examines the chemical compositions of eggshell powder (ESP) and lime as the soil stabilisers and compared with the compositions of cement and fly-ash to understand the optimal distribution of chemical stabilisers maximising the bearing capacity and structural integrity of subgrade soil. The different proportions of eggshell powder (ESP) (2%, 4%, 6% and 8% of total soil mass) were mixed with a fixed proportion of lime (6% of total soil mass) to analyse the optimum proportion of eggshell maximising the soi [...]

1301 11381

Open Access Original Research

A Large Eddy Simulation Study of Cyclones: The Effects of Interparticle Collisions on Erosion Prediction

Received: 31 January 2022;  Published: 06 May 2022;  doi: 10.21926/jept.2202017

Abstract

Cyclone separators are widely used in fluid catalytic cracking (FCC) units due to their lack of moving parts and relatively low-pressure drop. However, cyclone separators are prone to erosion-related issues, which is a major drawback. In this paper, a large eddy simulation (LES) of the particle-gas flow in a cyclone separator is investigated using a four-way Euler-Lagrange approach to model inter-particle collisions and the exchange of momentum between particles and fluid. The effects of inter-particle and particle [...]

1774 11380

Open Access Review

Abiotic Stress: Interplay Between ROS Production and Antioxidant Machinery, Signaling, and ROS Homeostasis

Received: 29 August 2022;  Published: 09 November 2022;  doi: 10.21926/obm.genet.2204171

Abstract

Climate change poses a substantial threat to global crop yield. Moreover, crop production is likely to reduce in the near future because of increasing average temperatures, widespread extreme climate events, and the loss of agricultural land. Abiotic stresses are the major factors limiting the growth and development of various crops worldwide. They cause the buildup of reactive oxygen species (ROS), which leads to cellular damage in a variety of subcellular compartments in plants. The metabolic rate of ROS is criti [...]

1659 11371

Open Access Research Article

Morpholine-Based Novel Ionic Liquid for Synthesis and Characterization of Triazolidinethiones and Their Biological Properties

Received: 03 December 2022;  Published: 12 March 2023;  doi: 10.21926/cr.2301011

Abstract

Keeping the green chemistry approach in mind we have synthesized a novel morpholine-based ionic liquid [NBMMorph]+Br-. The structure of Ionic liquid was confirmed by spectral techniques viz. IR, 1H NMR, and 13C NMR, analysis. The synthesized novel IL [NBMMorph]+Br- was utilized to prepare 1,2,4-triazolidine-3-thiones of biological significance. The [NBMMorph]+Br- IL shows excellent catalytic activity, and a simple filtration technique can separate the thiazolidinedione products. The structure of the synthesized com [...]

1929 11363

Open Access Original Research

Individual Radiosensitivity in Lung Cancer Patients Assessed by G0 and Three Color Fluorescence in Situ Hybridization

Received: 27 July 2018;  Published: 26 June 2019;  doi: 10.21926/obm.genet.1902082

Abstract

Background: It is well known that radiosensitivity varies substantially from individual to individual. This may influence the tumor response and also cause side effects in normal tissues following the radiotherapy treatment for cancers. Therefore, we aimed to analyze the sensitivity of a lung cancer cohort to see whether patients display similar radiosensitivity distribution as compared to healthy individuals. Methods: Blood samples of healthy individuals (n = 244) and a small group of lung cancer patients (n= 38) [...]

2105 11357

Open Access Original Research

Reconstruction of Anthropogenic Land-Cover Change for Middle America, 1500 CE

Received: 07 March 2021;  Published: 24 August 2021;  doi: 10.21926/aeer.2103020

Abstract

This project demonstrates how to use existing syntheses of many decades of historical social science research to produce empirically derived land-use maps in a GIS for large regions for a specific target year at a resolution appropriate to the calibration of existing anthropogenic land-cover change (ALCC) models. Disagreement among the outputs of various ALCC models results from differing estimates of population and assumptions about how much food a given population requires and the productivity per unit area of va [...]

1510 11354

Open Access Case Report

Constitutional Partial Proximal Trisomy 14q11.2 to 14q21: Two New Moroccan Cases and Review of the Literature

Received: 25 July 2018;  Published: 22 July 2019;  doi: 10.21926/obm.genet.1903085

Abstract

Background: A report of two new Moroccan cases with polymalformative syndrome, in which we identified similar but not identical sSMCs derived from chromosome 14. Methods: Conventional karyotype and MULTI-FISH. Results: +del(14)(q21.1) in the first case and +del(14)(q21.2) in the second. Conclusions: Constitutional partial trisomy 14 has an expanded clinical spectrum as one case from the literature was associated with gonadal tumor development. Similar cases, including the ones reported here, need to be carefully fo [...]

2160 11345

Open Access Original Research

Molecular Basis of Allogeneic Pluripotent Stem Cell Treatment of a Patient with Sporadic ALS

Received: 21 August 2020;  Published: 29 March 2021;  doi: 10.21926/obm.geriatr.2101164

Abstract

There are no curative strategies for ALS, and as a result the alternative therapies are gaining ground, in particular the stem cell-based therapies which hold a promising future. Here we describe an ALS patient, who by choice, received allogeneic human cord-blood derived multipotent stem cells (MSC) intravenously and intrathecally. This is the first snapshot of pre-and post-stem cell transplantation in an ALS patient through transcriptomic, epigenomic, and proteomic follow-up elucidating the effect of stem cells in [...]

1590 11341

Open Access Review

A Review on Acupuncture as a Non-Pharmacological Treatment for Neonatal Abstinence Syndrome (NAS)

Received: 07 June 2019;  Published: 20 August 2019;  doi: 10.21926/obm.icm.1903051

Abstract

The incidence of Neonatal Abstinence Syndrome (NAS) is increasing due to more mothers using illicit drugs. This results in an increase in costs and resources for the healthcare system. Newborns with NAS might experience withdrawal symptoms that can cause pain, distress, and may potentially increase the risk of future health complications. It is therefore important to find effective treatments that can alleviate NAS. Various non-pharmacological treatments are used in conjunction with pharmacological treatments to re [...]

2033 11341

Open Access Opinion

On Objectivity in Prenatal Genetic Care

Received: 16 April 2018;  Published: 12 June 2018;  doi: 10.21926/obm.genet.1802022

Abstract

We address an ongoing controversy over what health-care providers tell prospective parents about Down Syndrome (DS). Many parent, disability-rights, and anti-abortion activists believe that the messages that health-care professionals transmit to pregnant women and their partners are distorted. In their view, OB-GYNs, primary-care providers, clinical geneticists, midwives and other medical professionals generally assume that the quality of life for individuals with DS and their families is poor, whereas in fact, tho [...]

2097 11317

Open Access Short Communication

Newborn Screening in Latin America: A Window on the Evolution of Health Policy

Received: 22 August 2021;  Published: 21 January 2022;  doi: 10.21926/obm.genet.2201146

Abstract

Investigating the historical origins of a well-accepted health program across a region, such as newborn screening in Latin America, has the potential to reveal the role of historically-specific drivers in shaping national health policy. We reviewed published reports on NBS in Latin America and interviewed newborn screening experts with experience in the region. We found trends suggesting that the decrease in infant mortality may be a prerequisite to investing in nationwide screening for rarer conditions. We also no [...]

1475 11313

Open Access Original Research

Energy Storage and Installed Wind Capacity Requirements for the Substitution of Fossil Fuels in the Electricity Generation Sector

Received: 19 April 2021;  Published: 10 September 2021;  doi: 10.21926/jept.2103040

Abstract

The impending adverse effects of Global Climate Change encourages the substitution of fossil fuels with non-carbon sources for electricity generation. However, while fossil fuel power plants may generate electric power at demand, the most abundant renewable energy sources-wind and solar-are intermittent or periodically variable. This necessitates the development of adequate energy storage at the utility/grid level. Using actual data for the hourly energy demand in the ERCOT electricity grid, this study examines the [...]

1618 11310

Open Access Case Report

Generation of Unexpected Allele-Specific Anti-HLA Antibodies after the Transplantation of a Fully-Matched Kidney Allograft and the Diagnostic Approaches Required for Excluding Harmful Effects after Subsequent Renal Regrafts

Received: 26 January 2021;  Published: 02 June 2021;  doi: 10.21926/obm.transplant.2102142

Abstract

The specification of anti-human leukocyte antigen (HLA) antibodies is an important task for patients awaiting kidney allografts. Especially the patients immunized in previous transplantations, transfusions, or pregnancies must be carefully observed, since grafting patients with HLA antigens/phenotypes recognized by their pre-formed antibodies are the main cause of harmful hyperacute and acute rejection. The complement-dependent lymphocytotoxicity-based de facto (physical) crossmatching (CDC-CM) has thus been implem [...]

1881 11307

Open Access Review

A Review of Clinical Influencing Factors in the Selection of Cardiac Medications in the Elderly

Received: 14 January 2023;  Published: 31 May 2023;  doi: 10.21926/obm.icm.2302023

Abstract

Aging is a stage of the natural life cycle. It is a set of natural and coordinated growth changes all organs and body systems undergo to burnout. It is impossible to determine the exact time of old age for two reasons. First, the aging process is different for humans due to individual, hereditary factors. Second, aging has a set of physiological, psychological and, social factors. This review aimed to gather appropriate clinical information and facts for clinicians when practicing heart medications in elderly patie [...]

1512 11306

Open Access Case Report

Auriculotherapy for Intractable Hiccups-A Case Report

Received: 22 March 2019;  Published: 04 June 2019;  doi: 10.21926/obm.icm.1902034

Abstract

A 16 year old girl was evaluated for intractable hiccups for 6 six months, with a prior negative clinical and laboratory evaluation, and without any improvement with a variety of folk and medicinal therapies. A single treatment session of auriculotherapy produced a full clinical remission.

1987 11298

Open Access Case Report

Malignant Catatonia Requiring High Dose Bromocriptine: Case Report

Received: 23 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101089

Abstract

Catatonia can occur in patients diagnosed with schizophrenia and bipolar disorder and malignant catatonia is life threatening. Anti-psychotic medications should be discontinued during acute phase of catatonia. Anti-psychotic discontinuation in catatonia is a challenge in patients maintained on long-acting injectable antipsychotics because of the extended release. Case report: We present a case of malignant catatonia developed in a patient with history of schizophrenia and developmental delay. Symptoms lasted severa [...]

1446 11296

Open Access Original Research

Enhanced Photocatalytic Degradation of p-Nitrophenol and Phenol Red Through Synergistic Effects of a CeO2-TiO2 Nanocomposite

Received: 24 July 2022;  Published: 03 November 2022;  doi: 10.21926/cr.2204039

Abstract

Organic compounds are one of the most severe pollutants occurring in the environment. Hence, it is important to remove these compounds from the environment through remediation processes such as photocatalysis. The present study investigated the photocatalytic degradation of p-nitrophenol (NP) and phenol red (PR) using a cerium oxide-titanium oxide nanocomposite (CeO2-TiO2nc) under UV light. CeO2-TiO2nc was synthesized using the co-precipitation method. An X-ray diffraction (XRD) analysis confirmed the phase purity [...]

2385 11294

Open Access Original Research

Estimating Met-Ocean Parameters during a Tropical Cyclone for Marine Science and Engineering

Received: 16 April 2021;  Published: 16 June 2021;  doi: 10.21926/jept.2102025

Abstract

During a tropical cyclone (TC) worldwide, the Regional and Mesoscale Meteorological Branch (RAMMB) of NOAA/NESDIS (http://rammb.cira.colostate.edu/) issues real-time TC surface wind analyses. The purpose of this article is to provide value-added estimations of several meteorological and oceanographic (met-ocean) parameters including overwater friction velocity and turbulence intensity, variation of the wind speed with height, significant wave height, peak or dominant wave period, wind-driven currents and wind-stres [...]

2062 11292

Open Access Communication

Development of a Novel Pipette Tip-Aided Cell Cloning Method for The Effective Isolation of Genome-Edited Porcine Cell

Received: 11 October 2020;  Published: 10 March 2021;  doi: 10.21926/obm.genet.2101126

Abstract

Direct colony cloning of adherent mammalian cells using rings or dilution cloning has been used frequently for obtaining stable transfectants after gene delivery. As an alternative to these methods, successful isolation of the cells in a single colony is possible by placing a trypsin-immersed small paper disk onto the colony and subsequently picking up the paper with the assumption that it carries the trypsinized cells. However, the cloning success using this technique largely relies on the cell type used. In the p [...]

1992 11291

Open Access Review

Where’s Waldo? Extrahepatic Site Options for Islet Transplantation

Received: 29 October 2018;  Published: 24 January 2019;  doi: 10.21926/obm.transplant.1901042

Abstract

The current predominant location for allo- and auto-transplantation of islets is the liver. Despite the historical success of this site, recent studies have revealed multiple disadvantages. Portal hypertension, portal vein thrombosis, bleeding, low oxygen tension, instant blood mediated inflammatory reaction, inadequate alpha cell function, and delays in neovascularization are factors that continue to drive researchers to explore alternative sites for islet transplantation. Factors of an optimal site include: capac [...]

1624 11291

Open Access Research Article

Harvesting the Potential of CO2 before it is Injected into Geological Reservoirs

Received: 28 October 2021;  Published: 22 December 2021;  doi: 10.21926/jept.2104050

Abstract

To store CO2 in geological reservoirs, expansion valves have been used to intentionally release supercritical CO2 from high-pressure containers at a source point to lower-pressure pipelines and transport to a selected injection site. Using expansion valves, however, has some shortcomings: (i) the fluid potential, in the form of kinetic energy and pressure which can produce mechanical work or electricity, is wasted, and (ii) due to the Joule-Thomson cooling effect, the reduction in the temperature of the released CO [...]

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Open Access Case Report

A Case Series of Temozolomide in the Management of Refractory Prolactinomas

Received: 12 October 2018;  Published: 01 November 2018;  doi: 10.21926/obm.neurobiol.1804014

Abstract

Objective: To report three cases of refractory prolactinomas treated with Temozolomide (TMZ). Background: Prolactinomas account for 40% of pituitary adenomas. Dopamine agonists (DA) are the first line of treatment followed by surgical resection and radiation. TMZ is an oral chemotherapeutic agent used in gliomas, which has been given to patients with prolactinomas refractory to conventional treatments. Methods: Retrospective chart review was conducted for refractory prolactinoma patients treated between 2008 and 20 [...]

1973 11288

Open Access Short Report

Compassion-Focused Therapy and People with Intellectual Disabilities: A Renewed Focus

Received: 06 March 2022;  Published: 04 January 2023;  doi: 10.21926/obm.icm.2301002

Abstract

Compassion-Focused Therapy is an integrative therapeutic model with a wealth of evidence behind its efficacy. Its accessibility leads it to be a helpful therapeutic modality for the intellectual disability population. Its ability to aid the understanding of the person, us as clinicians, and the wider context around us give a depth of understanding not prioritised across all therapeutic models. This article explores Compassion-Focused Therapy in the context of working alongside people with intellectual disabilities. [...]

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