Register or Submit a manuscript.
Table of Content

Open Access Review

Migraine as a Common Extra-Intestinal Presentation of Celiac Disease

Received: 18 August 2020;  Published: 09 February 2021;  doi: 10.21926/obm.neurobiol.2101087

Abstract

Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcificat [...]

1808 17215

Open Access Original Research

Crustal Reservoir Flow Simulation for Long-Range Spatially-Correlated Random Poroperm Media

Received: 30 November 2020;  Published: 19 March 2021;  doi: 10.21926/jept.2101013

Abstract

In interest of accurately modelling wellbore production in convective geothermal systems, we draw attention to two approaches to numerical simulation of crustal fluid flow. The historical "strong" approach simulates the fluid mass conservation condition on a localised finite difference mesh approximation to poroelastic continua. The more flexible "weak" approach globally enforces fluid mass conservation by in effect integrating over all numerical mesh cells. Strong formulation crustal flow simulation emerged from n [...]

1806 9264

Open Access Case Report

Fluorescence in Situ Hybridisation (FISH) is the First Tool to Identify Hypodiploidy in Paediatric Acute Lymphoblastic Leukaemia

Received: 24 December 2018;  Published: 17 April 2019;  doi: 10.21926/obm.genet.1902073

Abstract

Hypodiploidy has a low incidence in childhood acute lymphoblastic leukaemia (ALL). Patients are usually stratified into three subgroups, to allocate the correct treatment according to their ploidy level: high hypodiploidy (40-45 chromosomes), low hypodiploidy (33-39 chromosomes) and near haploidy (23-29 chromosomes). In this paper, a case is presented of near-haploid childhood ALL where fluorescence in situ hybridisation (FISH) provided an insight into the near-haploidy chromosomal aberration initially missed on ro [...]

1805 12711

Open Access Technical Note

Towards Femtoscan-Assisted Analysis of Liquid Crystal Self-Organization on Different Polymer and Glass Surfaces for Lab-on-a-Chip and Lab-on-a-Dish Applications, Including Optofluidic and Flexoelectric Ones

Received: 27 December 2022;  Published: 29 May 2023;  doi: 10.21926/rpm.2302022

Abstract

In this paper, starting with an introductory review of the applications of liquid crystals and polymer-dispersed liquid crystal systems in (bio)sensors and microfluidics, the possibilities of visualizing self-organization products of liquid crystalline media or field-induced instabilities of liquid crystalline systems are considered. In particular illustrated cases, it is proposed to use FemtoScan software-containing metrological complexes to visualize instabilities in liquid crystalline systems and products of sel [...]

1804 8128

Open Access Case Report

Anticoagulation Rationale in an Elderly Patient with Stroke, Cerebral Amyloid Angiopathy, and Antiphospholipid Syndrome: A Case Report

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

Abstract

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

1802 8021

Open Access Original Research

Computational Micromechanics for the Optimization of Compression Strength of Unidirectional Carbon Fiber Composites for Use in Wind Turbine Blades

Received: 15 April 2020;  Published: 09 June 2020;  doi: 10.21926/jept.2002010

Abstract

As wind turbine blades grow longer, new design parameters gain additional importance such as blade weight, tip deflection and material cost. These parameters require designers to relook at carbon fiber as a potential design solution. However, the composite materials in wind turbine blades are subjected to significant compressive loading, and the compressive strength of carbon fiber reinforced polymer (CFRP) composites is much lower than its tensile strength. This reduction in compression strength is due to a change [...]

1802 9936

Open Access Review

Ischemic Brain Injury and Regulatory T Cells

Received: 13 January 2019;  Published: 27 March 2019;  doi: 10.21926/obm.neurobiol.1901023

Abstract

Inflammation and immune responses after stroke, including ischemic cerebral infarction, play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues, which subsequently regulate effector T cell activation and dendritic cell activation. Recently, Tregs that are present in tissues, called tissue Tregs, have been shown to exhibit tissue-specific functions in addition [...]

1802 12741

Open Access Case Report

Candida auris and Heart Transplantation. Preoperative Attitude.

Received: 15 October 2018;  Published: 27 February 2019;  doi: 10.21926/obm.transplant.1901053

Abstract

In recent years, several agencies have issued warnings about the spread of Candida auris infections, a multidrug-resistant yeast that is associated with serious infections and with a mortality rate that can reach 70%. This problem is especially serious in transplant recipients receiving intense immunosupressive therapy. There are no established criteria on the relevance of this colonization or on when the transplant should be contraindicated in these cases. Five cases of colonization and two of candidemia have been [...]

1802 11492

Open Access Review

Genotyping Pneumocystis jirovecii: Impacting Our Understanding of Interhuman Transmission

Received: 04 December 2018;  Published: 17 January 2019;  doi: 10.21926/obm.genet.1901060

Abstract

Pneumocystis jirovecii is an atypical fungus transmitted via the airborne route between humans. This fungus is exclusively associated with humans and almost each individual has encountered it at least once before reaching the age of two. P. jirovecii can be cleared and spontaneously resolutive in immunocompetent, whereas it can be responsible for severe Pneumocystis pneumonia (PCP) in immunocompromised patients. In the next decades, the putative increase of the population of immunocompromised patients is likely to [...]

1801 10923

Open Access Research Article

Family History, Genetic, and Other Cause-Related Beliefs among Breast Cancer Survivors

Received: 27 February 2019;  Published: 26 July 2019;  doi: 10.21926/obm.genet.1903087

Abstract

Patients’ lay theories about the cause of their cancer may influence patient behavior and adjustment, they have also been found to differ substantially from scientific evidence of cancer risk factors. This report describes beliefs about genetic causes of breast cancer, among 522 recently diagnosed breast cancer survivors participating in an observational study. Patients were asked to respond to an open-ended question about the cause of their cancer. Causes mentioned included family history, genetics, lifestyl [...]

1801 9838

Open Access Original Research

Risk and Protective Factors for Poorer Overall Health, Increased Psychological Distress, and Suicidal Ideation Due to SARS-CoV-2 outbreak in the General Japanese Population

Received: 28 December 2020;  Published: 12 March 2021;  doi: 10.21926/obm.icm.2101008

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is expected to have harmed the mental health of numerous people worldwide. Therefore, the present study was aimed to explore the effects of the SARS-CoV-2 outbreak on the overall health of the general Japanese population, with a particular focus on identifying the factors associated with a requirement for mental health treatment. Japanese residents aged 18 years and above were surveyed online, and among the 1,500 obtained responses included for a [...]

1801 8471

Open Access Research Article

Transcriptome Signatures of Dysregulated Brain Dynamics Induce Entangled Network States.

Received: 15 June 2020;  Published: 30 December 2020;  doi: 10.21926/obm.neurobiol.2004077

Abstract

Marks of brain disorders may be visible through abnormal networks characterized by states with distinct signatures or connectivity patterns. Apart from neurodegenerations, drug abuse or eventually addiction may exert complex perturbative effects over human health, including damage to various organs and especially brain inflammation, volume shrinkage and functional deficits. These can also be regarded as signs of accelerated ageing, which involve multiple comorbidities associated with long-lasting cognitive impairme [...]

1801 8757

Open Access Original Research

Low Cost, Enriched Collagenase-Purified Protease Enzyme Mixtures Successfully Used for Human Islet Isolation

Received: 29 March 2019;  Published: 24 May 2019;  doi: 10.21926/obm.transplant.1902064

Abstract

Background: Purified bacterial collagenase and protease enzymes are commonly used to recover human islets from clinical grade pancreata for subsequent clinical islet transplantation. The high cost of purified enzymes can be prohibitive for recovering human islets from research pancreata used for translational research or pre-clinical studies. In this study, we successfully isolated islets from human research pancreata using enriched collagenase products supplemented with BP Protease (DE Collagenase 800 or Collagena [...]

1801 14995

Open Access Review

Take a Seat for Yoga with Seniors: A Scoping Review

Received: 07 October 2021;  Published: 16 May 2022;  doi: 10.21926/obm.geriatr.2202197

Abstract

Chair yoga is a specific form of yoga practiced while seated on a chair, or standing using a chair for support; this adaptation allows those with impaired standing ability to practice safely. The purpose of this scoping review was to analyze the published literature regarding the use of chair/adapted yoga with older adults. Two researchers performed the review. Data sources: PubMed Central, CINAHL, Medline Full Text, Nursing and Allied Health, SPORT discus and TRIP were accessed. Study selection: Inclusion criteria [...]

1800 21045

Open Access Original Research

New Electrocatalysts Prepared by Co-Sputter Deposition for the Direct Oxidation of Methanol

Received: 25 May 2021;  Published: 13 August 2021;  doi: 10.21926/jept.2103038

Abstract

Direct methanol oxidation catalysts Pt1-x-Tax (0

1800 11474

Open Access Case Report

A Case Study on the Development of Math Competence in an Eight-year-old Child with Dyscalculia: Shared Intentionality in Human-Computer Interaction for Online Treatment Via Subitizing

Received: 24 January 2022;  Published: 18 May 2022;  doi: 10.21926/obm.neurobiol.2202122

Abstract

Studies in the field of neuroscience have shown that the neural network responsible for numeracy overlaps with the visual and spatial processing regions. Other studies in psychology also highlighted an association of visual-spatial processing with mathematical competence at the early stages of development. These findings suggest that research on the size of the focal area of attention (consciousness) can contribute to understanding the development of numeracy. In this case study, we verified the hypothesis of devel [...]

1800 14656

Open Access Original Research

The Induction of Histone H3K4 Methylation on the SI Gene Correlates with SI mRNA Levels in Enterocyte-Like Caco-2 Cells

Received: 18 December 2017;  Published: 30 October 2018;  doi: 10.21926/obm.genet.1804046

Abstract

Background: Histone modifications, including acetylation and H3 lysine 4 (K4) methylation, are thought to be associated with transcriptional activation during differentiation. Methods: mRNA and histone modifications around the sucrase-isomaltase (SI) gene in Caco-2 cells (a small intestine cell line) during differentiation were determined by qRT-PCR and chromatin immunoprecipitation, respectively. Results: Mono-, di-, and tri-methylation of histone H3K4 on the SI gene correlated with the induction of SI gene expres [...]

1798 8483

Open Access Opinion

Clonal Heterogeneity in Non-Small Cell Lung Cancer and the Possible Role in Predicting Response to Treatment with Immune Checkpoint Inhibitors

Received: 15 November 2018;  Published: 22 March 2019;  doi: 10.21926/obm.genet.1901069

Abstract

Immune oncology treatment with immune checkpoint inhibitors (ICIs) is revolutionizing therapeutic approach for advanced non-small cell lung cancer (NSCLC) patients, in terms of longer survival and improved quality of life. To date, the widely used and approved biomarker is programmed death ligand 1 (PD-L1) expression on tumour cells, but it is considered not accurate and it is more likely that many factors, related to both cancer and host, may better predict response to ICI. Among those factors, great attention is [...]

1798 9095

Open Access Original Research

An Exploration of the Experiences of Group Compassion Focused Therapy for Hospital Outpatients with Long-Term Mental Health Difficulties

Received: 07 April 2025;  Published: 12 January 2026;  doi: 10.21926/obm.icm.2601005

Abstract

There is now good evidence for the efficacy of Compassion Focused Therapy (CFT) for a variety of mental health difficulties. To deepen understanding of the processes underpinning CFT’s effectiveness, this service evaluation explored the experiences and reflections of individuals with long-term mental health difficulties who had previously received therapy and attended an 11-week CFT group. Ten clients were invited to the group; one withdrew before the group started because of work and personal commitments and anoth [...]

1798 3136

Open Access Original Research

Optimization of Heat Transfer in Parabolic Trough Collectors Using Advanced Turbulator Designs and Nanofluids

Received: 19 October 2024;  Published: 15 January 2025;  doi: 10.21926/jept.2501003

Abstract

Parabolic trough collectors (PTCs) are essential for solar thermal energy systems, and their thermal efficiency can be significantly enhanced using turbulators and nanofluids. This numerical study introduces three novel fin-spiral turbulator configurations (4, 7, and 10 blades) to enhance heat transfer within the absorber tube. Additionally, three nanofluid types including water-based single-walled carbon nanotubes (SWCNT), cupric oxide (CuO), and a hybrid SWCNT-CuO, at concentrations of 1%, 3%, and 5% were evaluat [...]

1797 9969

Open Access Opinion

Belatacept Dosing in Lung Transplantation: Is There a Method to the Madness?

Received: 09 July 2021;  Published: 30 August 2021;  doi: 10.21926/obm.transplant.2103152

Abstract

Data supporting the use of belatacept in non-abdominal organs are limited to case series and small cohorts involving patients requiring conversion due to CNI intolerance or contraindication. Review articles summarizing the efficacy of belatacept salvage therapy in lung transplantation have previously been published, however, dosing regimens are highly variable and uniform guidance is lacking. In this article, indications and considerations for belatacept use in lung transplant recipients are reviewed with a specifi [...]

1795 13545

Open Access Review

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Received: 07 May 2019;  Published: 29 July 2019;  doi: 10.21926/obm.neurobiol.1903035

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury, and its mechanisms have not been completely unraveled so far. The causative factors for the brain injury initiated by an aneurysm rupture, which is referred to as the early brain injury (EBI), include elevated intracranial pressure, cerebral hypoperfusion, and blood contents that are directly exposed to the brain surface. At Day 4–14 post aSAH, delayed cerebral ischemia (DCI) often develops, which may worsen the neurological outcomes critically. [...]

1794 11786

Open Access Original Research

Breaking Barriers: A Reliable Method for RNA Extraction in Zebrafish Neurodegenerative Research

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Abstract

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

1794 8041

Open Access Original Research

Modeling CO2 and N2 Permeation through Mixed Matrix Membranes Containing Oxygenated Carbon Nanotubes Dispersed in Polysulfone

Received: 09 May 2022;  Published: 16 August 2022;  doi: 10.21926/aeer.2203030

Abstract

Mixed matrix membranes (MMMs) consist of a polymeric phase and a dispersed solid filler such as zeolites or carbon nanotubes. We prepared symmetric and asymmetric polysulfone-based MMMs containing functionalized multi-walled carbon nanotubes (MWNT-O) for CO2/N2 separation. Maxwell’s model was used to predict the permeabilities of MMMs. The permeability achieved using the model exhibited a good fit of the model in symmetric MMMs, especially for CO2. This can be potentially attributed to the high affinity of th [...]

1793 8522

Open Access Review

Diagnosis and Treatment of Mitochondrial Abnormalities in Reproductive Medicine

Received: 08 April 2019;  Published: 14 August 2019;  doi: 10.21926/obm.genet.1903089

Abstract

Mitochondrial diseases are among the most prevalent inborn errors of metabolism. The overwhelming majority of mitochondrial diseases (about 85%) result from mutations in nuclear genes involved in oxidative phosphorylation, while some (15%) are caused by mutations in mitochondrial DNA (MtDNA). The familial mtDNA mutations are exclusively inherited from the mother. There are four main methods available to prevent the transmission of mtDNA mutations: preimplantation genetic diagnosis (PGD) or prenatal diagnosis (PND) [...]

1793 10915

Open Access Opinion

How to Heal the Healer: Combating Burnout Using Compassion and Mindfulness-Based Interventions

Received: 13 June 2019;  Published: 24 July 2019;  doi: 10.21926/obm.icm.1903047

Abstract

We explore how medical culture contributes to burnout. Highlighting specific programs aimed at developing compassion and mindfulness skills, we share our own perspectives and experiences implementing similarly focused programs. Promising results on the application of compassion-based programs show evidence of improvements to a number of measures of trainee wellbeing, particularly among the most vulnerable trainees, while results pertaining to mindfulness programs show improvements to performance as well [1, 2]. As [...]

1793 8799

Open Access Original Research

Mesoporous Silica Nanoparticles to Tune Oxidative Degradation Rates in Composite Shape Memory Polymers

Received: 12 September 2019;  Published: 31 December 2019;  doi: 10.21926/rpm.1904008

Abstract

Biomedical applications of shape memory polymers (SMPs) are limited by their biostability, degradability, and possible toxicity risks after implantation. Mesoporous silica nanoparticles (MSNs) were used to increase the oxidative biostability (increase time until degradation occurs) using antioxidants and to induce oxidative degradation through incorporation of hydrogen peroxide-containing MSNs with modified surfaces. The presented results confirm increased oxidative stability using antioxidants, and alternatively, [...]

1793 10958

Open Access Review

Mechanisms of Origin and Clinical Effects of Multiple Small Supernumerary Marker Chromosomes, Each Derived from a Different Chromosome

Received: 15 November 2016;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701002

Abstract

Small supernumerary marker chromosomes (sSMCs) are centric chromosome fragments additionally present in an otherwise normal human chromosome set that cannot be characterized by classical cytogenetic techniques alone. The majority of sSMCs are not yet related to a defined clinical phenotype. We compiled from the literature all 78 cases with multiple sSMCs per cell in which the chromosomal origin of the sSMCs has been identified. The number of sSMCs varies from 2 to 7; 64% have 2 sSMCs, 14% have 3 sSMCs, and the freq [...]

1792 11492

Open Access Original Research

Micromechanics-Based Modeling of SiC/SiC Ceramic Matrix Composites and Structures

Received: 23 January 2023;  Published: 20 June 2023;  doi: 10.21926/rpm.2302025

Abstract

The behavior and response of ceramic matrix composites (CMCs), in particular silicon carbide fiber reinforced silicon carbide matrix (SiC/SiC), is affected by many factors such as variation of fiber volume fraction, residual stresses resulting from processing of the composites at high temperature, random microstructures, and the presence of matrix flaws (e.g., voids, pores, cracks etc.) as well as general material nonlinearity and heterogeneity that occurs randomly in a composite. Residual stresses arising from the [...]

1792 12302

Open Access Original Research

Normalized Difference Vegetative Index-related Assessment for Climate Change Impact on Indigenous Communities from High Resolution IKONOS Satellite Imagery in West Papua

Received: 29 October 2020;  Published: 09 July 2021;  doi: 10.21926/aeer.2103018

Abstract

High-resolution satellite imagery permits acquisition of critical data to observe climate-change and environmental impact on conflict-impacted indigenous communities with co-existing socio-economic factors, often within unstable regimes. Conflict may prevent direct access in remote regions to validate civilian conflict actor evidence. In such cases use of remote sensing tools, techniques, and data are extremely important. Software-based imagery assessment can quantify radiometrically calibrated or Normalized Differ [...]

1791 12435

Open Access Research Article

Living Well with Illness: Evaluation of a Transdiagnostic Compassion-Focused Therapy Group for Long-Term Health Conditions

Received: 31 May 2022;  Published: 10 August 2022;  doi: 10.21926/obm.icm.2203035

Abstract

This study presents a mixed methods evaluation of a transdiagnostic Compassion Focused Therapy (CFT) group intervention, for adults with long-term health conditions (LTHCs). It aims to assess whether group completion was associated with improved outcomes in mood, overall well-being and the extent of LTHC interference in confidence for managing daily activities. Additionally, it examines the extent to which changes were related to processes targeted by CFT. The ‘Living Well with Illness’ group consisted of eleven we [...]

1791 12868

Open Access Original Research

The Impacts of Offshore Wind Farms (OWFs) on Local Tourism and Recreation -- Evolving Lessons from Practice

Received: 06 July 2022;  Published: 16 November 2022;  doi: 10.21926/jept.2204037

Abstract

The article examines the nature of impacts of the rapidly growing Offshore Wind Farm (OWF) industry on tourism and recreation in coastal communities, especially in the UK. The multi-methods research approach includes reviews of literature, content of OWF Environmental Statements (ESs) for predicted impacts, recent practice for actual impacts, and the use of mitigation and enhancement measures. Findings from literature indicate that the overall impact on tourism appears relatively benign, and sometimes positive. The [...]

1791 17120

Open Access Original Research

Prediction of ADRs and Estimation of Polypharmacy in Older Patient’s Population: Retrospective Study in Russian Gerontology Center

Received: 10 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.geriatr.1901038

Abstract

Background: Adverse drug reactions (ADRs) are common in the elderly and often have serious clinical and economic consequences. Prediction of ADRs is a valuable tool to improve pharmacotherapy and outcomes in this category of patients. Objective: Prediction of ADRs in patients ≥ 65 years old, based on GerontoNet risk score with emphasis on polypharmacy. Methods: Pharmacoepidemiological retrospective study of medical records of patients admitted to the Russian Gerontology Clinical Research Center (RGCRC) between 1 [...]

1789 11877

Open Access Research Article

The PBAR Protocol: Antipsychotic Medication Reduction in the Nursing Home

Received: 24 November 2020;  Published: 15 June 2021;  doi: 10.21926/obm.geriatr.2102172

Abstract

Neuropsychiatric symptoms (NPS) occur in almost all persons living with dementia. Antipsychotic medications are often prescribed inappropriately for persons living with dementia who experience NPS. Adverse side effects of antipsychotic medications include falls, sedation, cognitive dysfunction, prolonged QTc interval, extrapyramidal side effects, cerebrovascular events, metabolic changes, infection, and mortality. The purpose of this descriptive quality improvement project was to test the feasibility and preliminar [...]

1787 326127

Open Access Original Research

An Open Source LoRa Based, Low-Cost IoT Platform for Renewable Energy Generation Unit Monitoring and Supervisory Control

Received: 16 November 2021;  Published: 17 February 2022;  doi: 10.21926/jept.2201007

Abstract

SCADA provides real-time system monitoring by constant communication and data exchange between various system devices to achieve data visualization and logging. Presently, in industrial systems, commercial SCADA systems are being used for data monitoring and control. These systems can be expensive, and as such can only be afforded by select industries. Even at these costs, the commercial SCADA systems face some challenges, which include interoperability and scalability issues. Research has shown that these problems [...]

1787 20330

Open Access Original Research

Simplifying Caregiver Resources in Eldercare: Identifying the Support Needs of Caregiving Employees

Received: 26 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.geriatr.1804024

Abstract

Background: The majority of long-term care provided to older adults and persons with disabilities is provided by unpaid family caregivers and friends. Employers have a stake in long-term care services as well since 60% of caregivers are employed outside the home, 49% have gone in late, left early, or taken time off during the day to deal with caregiving issues, and 15% have taken a prolonged leave of absence. Additionally, 87% of employed caregivers make telephone calls for caregiving from work. Presenteeism, the s [...]

1786 11740

Open Access Research Article

Integrated Oncology in an Integrated Medicine Hospital in Pitigliano (Grosseto, Italy)

Received: 29 September 2018;  Published: 01 February 2019;  doi: 10.21926/obm.icm.1901008

Abstract

Background: Complementary medicines (CM), including homeopathy, acupuncture, and traditional Chinese medicine, have been introduced for cancer patients undergoing chemotherapy and radiotherapy treatment in the Pitigliano Hospital Centre of Integrated Medicine in order to minimize the side effects of these treatments, which improves quality of life and adherence to conventional therapies. Methods: Cancer patients (240) were enrolled in an integrated care model offering a comprehensive protocol including homeopathy a [...]

1786 9261

Open Access Original Research

Exploring the Use of Purple Corn Cob Flour as a New Fiber Source in Pan Bread Improved by Commercial Hemicellulases

Received: 08 May 2024;  Published: 05 September 2024;  doi: 10.21926/rpn.2403013

Abstract

Bread stands out for its versatility and accessibility, appealing to individuals across various ages and social classes. Consequently, it presents an attractive opportunity for incorporating ingredients that offer health benefits to consumers. In this context, the current study aimed to evaluate the technological properties of sandwich bread (specific volume, water activity, moisture, instrumental color, and texture) prepared with a partial substitution (5% w/w) of wheat flour (WF) with purple corn cob flour (PCF) [...]

1785 8891

Open Access Review

The Role of Land Use Planning in Urban Transport to Mitigate Climate Change: A Literature Review

Received: 13 May 2022;  Published: 26 August 2022;  doi: 10.21926/aeer.2203033

Abstract

With the growing urbanisation phenomenon, ambitious policy interventions are needed to limit transport-related greenhouse gas emissions in urban areas. Cities are a predominant source of pollution, with urban transport contributing significantly to emissions. To address climate change, decision-makers must implement appropriate and effective mitigation instruments. This literature review focuses on the different approaches and supporting measures of urban transport land-use planning, such as mixed-used zoning plans [...]

1784 14886

Open Access Concept Paper

Understanding the Functional Roles of Multi-Modal Processing and Gc Activation In Older People's Performance in Caregiving Training

Received: 05 October 2018;  Published: 25 December 2018;  doi: 10.21926/obm.geriatr.1804026

Abstract

The current article addresses the working memory constraints experienced by older people in caregiving training. Two different approaches aiming to free the older people’s working memory space were discussed. They include multi-modal visual processing and Gc activation. The emphasis was on the theoretical underpinnings of both approaches with empirical evidence from the research and literature to demonstrate their effectiveness in older people’s caregiving training. Further discussion was made with respect to the t [...]

1784 11513

Open Access Research Article

Visuospatial Executive Functions are Improved by Brief Brain Training in Young Rugby Players - Evidence of Far Transfer Test Effects: A Pilot Study

Received: 05 March 2019;  Published: 06 May 2021;  doi: 10.21926/obm.neurobiol.2102093

Abstract

Brain training apps are becoming increasingly popular for at home use and as an adjunct to more traditional therapies. There is uncertainty about whether the effects of brain training transfer to real-world cognition, or performance on other cognitive assessment tests, or is specific only to the brain training app. Executive functions (EF’s) are higher-order cognitive processes important for activities of everyday living and autonomous goal-directed behaviour [1]. EF’s are associated with frontal brain networks tha [...]

1783 13914

Open Access Original Research

Assisted Phytostabilization of Acidic Polymetallic Mine Tailings Using Marble Waste and Native Plant Citrullus colocynthis: Effect on Soil, Plant, and Metal Uptake

Received: 29 December 2020;  Published: 22 July 2021;  doi: 10.21926/rpm.2103030

Abstract

This study aimed to assess the effectiveness of the phytostabilization ability of the native Moroccan plant Citrullus colocynthis on the neutralization of soil acidity and stabilization of metallic trace elements (MTEs) assisted by marble waste. Mine tailings (MT) collected from an abandoned polymetallic site were mixed with powdered marble (PM) using different mixing ratios (%): (MTPM25), (MTPM50), (MTPM75), and agricultural soil (AS) acting as the control. Seeds of C. colocynthis were selected and planted under g [...]

1783 8776

Open Access Research Article

Comparative Analysis of Machine Learning Models and Explainable Artificial Intelligence for Predicting Wastewater Treatment Plant Variables

Received: 30 July 2024;  Published: 17 October 2024;  doi: 10.21926/aeer.2404020

Abstract

Increasing urban wastewater and rigorous discharge regulations pose significant challenges for wastewater treatment plants (WWTP) to meet regulatory compliance while minimizing operational costs. This study explores the application of several machine learning (ML) models specifically, Artificial Neural Networks (ANN), Gradient Boosting Machines (GBM), Random Forests (RF), eXtreme Gradient Boosting (XGBoost), and hybrid RF-GBM models in predicting important WWTP variables such as Biochemical Oxygen Demand (BOD), Tot [...]

1782 12854

Open Access Original Research

Design and Techno-Economic Evaluation of a Hybrid Mini-grid System for an Academic Institution

Received: 26 September 2023;  Published: 03 April 2024;  doi: 10.21926/jept.2402010

Abstract

Inadequate electricity supply is a global challenge that needs solutions. This situation has compelled the purchasing of fossil fuel-generating units for use in residential, commercial, and industrial sectors to generate electricity. However, using fossil fuel generating units cause greenhouse gas emissions, bringing about environmental pollution and ultimately resulting in climate change. In particular, educational institutions require adequate and reliable power supply to ensure proper learning and teaching, whic [...]

1782 11014

Open Access Original Research

The Donor – Recipient Weight Ratio is a Reliable Marker for Cell Yield in Hematopoietic Stem Cell Donations

Received: 22 November 2021;  Published: 24 December 2021;  doi: 10.21926/obm.transplant.2104156

Abstract

Bone marrow transplants remain an import source of hematopoietic stem cells for patients suffering from specific diseases like aplastic anemia, for pediatric patients with malignant and non-malignant blood cell disorders, and for situations in which graft-versus-host disease (GvHD) is a concern. Identifying the optimal donor to achieve a 3-5 x 108/kg of recipient weight TNC yield may be challenging. In an analysis of 687 consecutive donors, donor and procedure characteristics were related to TNC/kg of recipient wei [...]

1782 14386

Open Access Review

Stem Cell Strategies to Promote Islet Transplantation Outcomes

Received: 02 April 2018;  Published: 05 June 2018;  doi: 10.21926/obm.transplant.1802010

Abstract

Pancreas or islet transplantation is the only reliable cure for Type 1 Diabetes. However, shortage of donor tissue supply, longitudinal graft attrition due to innate and adaptive immunity and the recurrence of autoimmunity, as well as the harmful side-effects of chronic immunosuppressive therapy limit the wide-spread acceptance of islet transplantation as a mainstream cure for autoimmune diabetes. Herein, preclinical and clinical stem-cells based research approaches aimed at obtaining large quantities of islets for [...]

1781 10362

Open Access Research Article

Characterization of Early Indicators of Cardiac Allograft Vasculopathy Lesions in a Rat Model Using Non-Invasive Cellular MR

Received: 07 January 2019;  Published: 29 August 2019;  doi: 10.21926/obm.transplant.1903083

Abstract

Background: Cardiac allograft vasculopathy (CAV) remains a major obstacle to long-term heart allograft survival. A number of studies show that immune mechanisms are involved in CAV. Using non-invasive cellular MRI (CMRI) to explore indicators of CAV lesions and characterize its development could provide new insights into the target immune cells that are responsible for the progression of CAV and reveal early markers of the disease before irreversible changes occur. Methods and Results: Rat heart transplant allograf [...]

1781 9349

Open Access Original Research

The Tension Between Growth and Innovation Led Greenhouse Gas Reductions in the Information and Communication Technology and Media and Entertainment Sector: A Case Study of AT&T Inc.

Received: 13 January 2022;  Published: 15 April 2022;  doi: 10.21926/aeer.2202013

Abstract

With scientific consensus on climate change and growing public concern, firms are recognising the multiple risks associated with inaction on their Greenhouse Gas (GHG) emissions. The Information and Communications Technology (ICT) and Entertainment & Media (E&M) sectors provide essential communications services, that are foundational for much of the modern world's social and economic systems. The ICT sector has already demonstrated success in innovations that enable emissions reductions. At the same tim [...]

1776 15362

Open Access Original Research

Pd-Cu Bimetallic Based Catalysts for Nitrate Remediation in Water: Synthesis, Characterization, and the Influence of Supports

Received: 29 January 2022;  Published: 21 April 2022;  doi: 10.21926/cr.2202011

Abstract

The use of Pd-Cu bimetallic catalysts in the reduction of aqueous nitrate ions by hydrogen was studied. The catalysts were supported on multi-walled carbon nanotubes (MWCNTs), activated carbon (AC), and Titania, and the influence of the support on the nitrate reduction activity in water was then investigated. The catalysts were characterized before and after use by FT-IR, XRD, SEM, EDX, and Laser Granulometry. It was found that the surface characteristics of the support have an influence on the catalyst activity, w [...]

1776 12574

Open Access Review

Reminiscence from Half a Century of Anti-Pneumocystis Drug Discovery and Development

Received: 12 September 2018;  Published: 06 December 2018;  doi: 10.21926/obm.genet.1804052

Abstract

My experiences with the identification and development of the anti-Pneumocystis drugs trimethoprim-sulfamethoxazole, dapsone and atovaquone are recounted. Attention is drawn to certain often-overlooked aspects of these drugs, including their concomitant effects against infections other than Pneumocystis, matters of dosing and adverse effects. During the past four decades several million people worldwide received chemoprophylaxis and treatment with these drugs for Pneumocystis jirovecii pneumonia. The population of [...]

1776 13894

Newsletter  

TOP