Open Access Short Communication
Home-Based Appetite-Guided Weaning of Enteral Nutrition of Infants with Congenital Heart Disease: A Preliminary Clinical Observation
Abstract
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Open Access Short Communication Home-Based Appetite-Guided Weaning of Enteral Nutrition of Infants with Congenital Heart Disease: A Preliminary Clinical ObservationAbstract
Infants with a critical congenital heart defect are at high-risk for feeding difficulties, often necessitating feeding tube placement. Enteral nutrition (EN) support is initiated to meet nutritional requirements and promote growth pre- and post-operatively. Tube-fed infants with congenital heart disease (CHD) who achieve stable health status post-operatively are at risk of becoming feeding tube dependent (FTD). We report a clinical observation for infants with CHD based on survey results from Growing Independent Ea [...] 1776 9557 |
Qualitative Evaluation of Interdisciplinary Service Learning Experience to Assess and Manage Fall Risk in Community-Dwelling Older Adultsby
Abstract
Aim: The purpose of this study was to evaluate faculty and student perceptions of a fall risk assessment and prevention activity for older adults offered in multiple community settings by health professional faculty and students.
Background: In the US, the percentage of adults 65 and older who fell was more than 29% in 2018. Among states, Arkansas ranks 48th with 35.2% of older adults reporting a fall (CDC Behavioral Risk Factor Surveillance System, 2018).
Methods: Four senior centers in Northwest Arkansas hosted a [...] 1774 10814 |
A Large Eddy Simulation Study of Cyclones: The Effects of Interparticle Collisions on Erosion Predictionby
Abstract
Cyclone separators are widely used in fluid catalytic cracking (FCC) units due to their lack of moving parts and relatively low-pressure drop. However, cyclone separators are prone to erosion-related issues, which is a major drawback. In this paper, a large eddy simulation (LES) of the particle-gas flow in a cyclone separator is investigated using a four-way Euler-Lagrange approach to model inter-particle collisions and the exchange of momentum between particles and fluid. The effects of inter-particle and particle [...] 1774 11380 |
Cognitive Reserve: Cognitive Abilities that Shield Against Dementia SymptomatologyAbstract
Background: Cognitive reserve describes the capacity for cognitively normal functioning despite brain damage. Previous research on cognitive reserve outlined how characteristics of the brain promote good cognitive functioning, although it is not yet clear what cognitive processes help individuals to maintain good cognitive functioning in the face of brain damage. Methods: Narrative review of relevant articles identified in literature searches for cognitive and/or psychometric characteristics of cognitive reserve. R [...] 1772 10585 |
Vanadium: Biological, Environmental, and Engineering AspectsAbstract
Vanadium is an element that is widely distributed in Earth’s crust as well as in sea-water and ground-water reservoirs. Therefore, it exerts a great influence on the issues related to life and environment. Vanadium is utilized by several marine organisms. For example, there are vanadate-dependent haloperoxidases in algae and several bacteria, e.g., Azotobacter, use it for nitrogen fixation and bacterial reduction involves the conversion of vanadate to oxidovanadium (IV). The similarity between vanadate and phosphat [...] 1771 16123 |
Application of the FISH Method for Analyzing Chromosome Segregation Patterns in Preimplantation Embryos from Robertsonian Translocation Carriersby
Abstract
Robertsonian translocations (RTs) are very common balanced structural chromosome rearrangements in humans. Due to alterations in the chromosome segregation pattern and the formation of unbalanced gametes and embryos, the carriers of RTs have a significant risk of reproductive failure. For over 30 years, fluorescent in situ hybridization (FISH) has been used for preimplantation genetic testing for chromosomal structural rearrangement (PGT-SR) in carriers of RTs. The data obtained by performing FISH for PGT-SR can be [...] 1768 11911 |
Ellagic Acid - A Dietary Polyphenol with Anticancer Activity that Deserves More ConsiderationAbstract
Ellagic acid (EA) the principal polyphenol of pomegranate (Punicca granatum) is renowned for its beneficial therapeutic activity in several diseases including cancer. Studies have shown that EA exerts a carcinopreventive effect on many cancer cells, inducing cell cycle arrest and apoptosis, and limiting neovascularization and cell migration. In animal models, EA could reduce tumor development, number and size. Research detected that EA exerts its activity on cancer cells through several signaling pathways, without [...] 1768 14544 |
Analysis of Surface Water Areal changes using Remote Sensing Databy
Abstract
Inland water bodies are crucial for supporting human life in various parts of the world. Therefore, it is essential to accurately monitor its spatiotemporal variations for better water management. The main objective of this study is to investigate the application of remote sensing data for quantifying the surface area changes and the impact of climatological variabilities over Lakes Mead and Chapala. Historical time series of monthly surface area dynamics were developed using Landsat 1-8 scenes and the climate vari [...] 1766 12251 |
Implications of Clozapine Complications in Geriatric Patients with Type II Diabetes MellitusAbstract
Second-generation antipsychotics, have known metabolic side effects; specifically, clozapine is implicated in worsening or causing hyperglycemia, hypercholesterolemia and weight gain. Recently, there has been an increased interest in the safe use of clozapine in patients with diabetes. In March 2018, a 65-year-old female with a diagnosis of schizophrenia was admitted for inpatient hospitalization to a psychiatric hospital in Buffalo, NY for further stabilization after receiving two months of treatment at a comprehe [...] 1766 11761 |
A New Chiral Cyclopalladated Ferrocenylimine Self-assembly Polymeric Film supported on Silicon for Heck and Suzuki-coupling ReactionsAbstract
A new chiral cyclopalladated ferrocenyl imine catalyst (called 4a2) was designed and synthesized, and its self-assembly catalytic polymeric brush supported on silicon (denoted as Si@PB4a2) was also fabricated by surface-initiated atom transfer radical polymerization (ATRP) and characterized. The catalytic properties of monomer 4a2 in homogeneous and Si@PB4a2 in heterogeneous in Heck and Suzuki cross-coupling were investigated, respectively. They exhibited higher catalytic activity in Heck, and Suzuki coupling react [...] 1765 9213 |
The Evolution of DNA Typing in Agri-Food ChainAbstract
Background: DNA typing has revolutionized not only diagnostics and forensics but also how we can analyze food. A number of techniques have been successfully applied for DNA analysis of plant-derived food. However, unlike forensics, a universally employed method has not yet emerged.
Methods: A keyword-based search was performed using the ISI-Web of Science database to look for research articles on DNA testing in agri-food chain. After screening and eligibility check, a Systematic Review was compiled focusing on the [...] 1765 10296 |
Balance and Fall Rates are Associated with Chronic Pain, and Improve with Yogaby
Abstract
Background: Falls are relatively common in older adults and are associated with chronic pain. Chronic pain may even be a predictor of falls in older adults. However, this relationship has not been studied in adults 1765 10464 |
Responsible Implementation of Expanded Screening Programs for Genetic Diseases at the Beginning of LifeAbstract
Technology makes it possible to expand many of the current screening programs. Initiatives for preconception screening of carrier status of recessive diseases, prenatal screening of aneuploidies and neonatal screening were initially undertaken by targeting one or at most, a few, conditions. Tandem mass spectrometry and genomic technologies, such as sequencing and panel testing, make it possible to increase the scope of these programs to include more disorders or markers. While inclusion of a larger number of condit [...] 1763 7575 |
Facilitation of Social Support through Negative Allosteric Modulation of α5-Associated GABAA Receptors: A Novel Mechanism for the Treatment of Depression, Agitation, and Aggression in the Elderlyby
Abstract
Major depressive disorder is a highly-prevalent and debilitating disorder in the aged population. Accumulating clinical evidence suggests a key role for social support in helping to mitigate depression. Preclinical data are reviewed that indicate that selective negative allosteric modulation of α5-containing GABAA receptors, as with RY-080, might rapidly impact depression in patients. Further, preclinical data in transgenic mice modeling neurodegenerative diseases has suggested that this mechanism might also [...] 1763 10895 |
Impact of SARS-CoV-2 Outbreak on Physical and Mental Health, Psychological Distress, and Suicidal Ideation, and the Mediating Role of StressorsAbstract
This study investigated the physical and psychological impacts of elements related to coronavirus disease (COVID-19) and demographic data in Japan both directly and as mediated by stressors, immediately following the rescinding of the state of emergency declaration accompanying the severe acute respiratory syndrome coronavirus 2 outbreak. An online survey was administered to 1,500 Japanese registered with an online outsourcing service. Data were analyzed with structural equation modeling using Mplus. Relatively lar [...] 1763 9087 |
Maintenance Optimization of Wind Turbines Using Weather-Dependent Equivalent Age Modelby
Abstract
Aging models are important input into wind farm maintenance and financial viability models. Aging of wind turbines depends on many factors, including both ambient and usage conditions. This paper presents a virtual age based maintenance model for wind turbines considering the effect of wind speed and ambient air temperature on turbine aging. Two maintenance thresholds (i.e., corrective threshold and preventive threshold) and three repair actions (i.e., unscheduled corrective, scheduled corrective and preventive act [...] 1763 12690 |
Cryptic Resilience: Decoding Molecular Networks in Pearl Millet for Enhanced Heat Stressby
Abstract
Pearl millet (Pennisetum glaucum), a vital cereal crop renowned for its drought tolerance, is a cornerstone for smallholder farmers in arid and semi-arid regions, ranking as the fifth most significant cereal globally. Despite its resilience, the molecular mechanisms underlying its tolerance to heat stress remained elusive. To address this knowledge gap, we subjected ten-day-old pearl millet seedlings to an unprecedented temperature of 50°C for 60 seconds. Subsequent next-generation RNA sequencing aimed to unrav [...] 1762 8256 |
Self-Care Options for Resilient Educators (SCORE) Teaches Aspiring Teachers How to Manage Stress in Light of COVID-Related DisruptionsAbstract
Self-Care Options for Resilient Educators (SCORE) is an 8-week, asynchronous virtual training program that teaches stress management skills relevant to educators’ job-related responsibilities and interpersonal interactions. From January-April 2020, 27 pre-service teachers participated in a quasi-experimental study of SCORE’s feasibility and preliminary efficacy. Volunteers chose to either complete SCORE concurrent with their teaching internship or to complete the same assessments for comparison purposes. Recruitmen [...] 1762 14163 |
Hot Topics on Nutrition in IBDby
Abstract
Inflammatory bowel diseases (IBD) affect primarily the bowel, but they are multisystemic diseases with a wide range of extraintestinal manifestations and complications. Nutritional imbalance occurs frequently in patients with IBD. The spectrum of malnutrition goes from undernutrition (low protein-caloric intake, disease-related malnutrition, micronutrient deficiencies) to overnutrition and obesity. The nutritional status of patients with IBD is increasingly recognized as a key aspect of the treatment and must be ad [...] 1762 13024 |
Theory and Interpersonal Processes in Compassion Focused TherapyAbstract
This paper reviews key theories underlying the interpersonal process in Compassion Focused Therapy (CFT) and links these to purported mechanisms of action in CFT. The paper goes on to provide a concrete practice example of an exampled dialogue between a clinician and client and narrates the interpersonal processes and mechanisms of action in an attempt to elucidate how interpersonal processes can be leveraged to facilitate therapeutic change. In so doing, this paper seeks to advance scholarship on precise mechanism [...] 1760 12949 |
TEA of a Unique Two-Pathways Process for Post-Combustion CO2 CaptureAbstract
A unique two-Pathways process using aqueous sodium glycinate for CO2 capture from a split flue gas stream emitted from 600 MWe post-combustion coal power plant was developed in Aspen Plus v.10. The split gas flow rate used was 44.75 ton/h and contained 0.0023 mol% SO2 and 13.33 mol% CO2. The process includes a washing unit, a CO2 absorption unit, a reverse osmosis unit, and a solvent regeneration unit or an ultrafiltration unit. The washing unit uses deionized water to completely remove SO2 and the CO2 absorption u [...] 1759 9288 |
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Open Access Short Communication Efficacy of a Plant-based Diet (Semi-lacto-ovo-vegetarian Diet) for Treating ConstipationAbstract
A modern lifestyle, including dietary westernization, has increased the prevalence of constipation. The authors developed a plant-based diet for inflammatory bowel disease. This study investigated whether a diet containing a high amount of dietary fiber is also effective for constipation. Consecutive patients with constipation were recruited in this study from April 2003 to March 2004. Their constipation was unresponsive to a conventional laxative. The patients were provided a plant-based diet during hospitalizatio [...] 1759 116446 |
Senescence and DNA Damage in Adipocytes and Fat Tissues and Its Potential Amelioration through Nutritional Interventionsby
Abstract
Accumulating evidence demonstrates that senescence and the associated inflammatory phenotype (SASP) also occur in post-mitotic cells such as mature adipocytes. Visceral adipose tissue in humans is susceptible to inflammation due to nutritional imbalance and ageing. However, while adipose tissue has been well researched in the context of obesity, senescence of differentiated adipocytes has not been investigated thoroughly. Our group recently demonstrated that ageing and normal ad libitum (AL) nutrition in mice resul [...] 1759 13419 |
Surface Water Changes and Water Depletion of Lake Hamrin, Eastern Iraq, Using Sentinel-2 Images and Geographic Information SystemsAbstract
Iraq’s lakes and rivers are currently exposed to drought because of climatic and political conditions. This study uses satellite images and geographic information systems to display the water depletion and the change in the surface water area of Hamrin Lake. Sentinel-2 imagery of 2018 and 2022 was used to analyze the surface water area changes and water depletion. A comparison was made by studying the changes that happened between 2018 and 2022 respectively. Moreover, a supervised classification technique was [...] 1757 11279 |
Encoding, Regression, and Classification of Transcription Factors’ Specificity and Methylation Effectsby
Abstract
The methylation effects on protein-DNA interactions, which can be perceived as a special kind of specificity of transcription factors, have been successfully quantified in the last years by various methods. In this work, I give a summary about the sequence encoding scheme, the underlying additive model about specificity and methylation sensitivity, and the regression strategy to analyze Methyl-Spec-seq data. Then I explain why given the current experimental setup, it is more appropriate to model the methylation eff [...] 1757 8503 |
Osteoporosis in Postmenopausal Women with Breast CancerAbstract
Breast cancer and osteoporosis are both diseases of aging. The "one in eight" lifetime risks of breast cancer occur primarily in the sixth, seventh, eighth, and ninth decades of life. One-third of postmenopausal women will experience an osteoporotic fracture. It is the coalescence of osteoporosis, breast cancer, and breast cancer treatments that, in some cases, increases the risks of osteoporotic fracture. That makes it imperative to assess risk factors, screen, and prevent or treat osteoporosis in postmenopausal w [...] 1757 10963 |
Coping with Burnout in the Healthcare Fieldby
Abstract
The healthcare industry is the largest and fastest growing industry in the world; however, being a part of the healthcare system involves being at an increased risk of experiencing mental health problems, loneliness, stress, and increased susceptibility to experiencing compassion fatigue related to the emotional wear associated with providing patient-centered care. Healthcare workers include, but are not limited, to physicians, nurses, allied health professionals, and psychologists. Often, healthcare workers place [...] 1756 9330 |
Impact of Osteophytectomy on Swallowing Function in a Patient with Chronic DysphagiaAbstract
Anterior cervical osteophytes are common in the geriatric population. Dysphagia can occur in individuals suffering from these spinal abnormalities. Surgical intervention is an uncommon course of treatment for these patients, but is often utilized as a last resort with the hope of swallow recovery. The purpose of this article is to highlight a unique case study documenting the required treatment course for dysphagia associated with osteophytes and subsequent osteophytectomy. We review current literature of both cons [...] 1755 14550 |
The Surgical Approach for Obtaining Abdominal Wall Closure in Renal Transplant Recipients with Temporary or Permanent Loss of Fascial Integrity Following Emergency Reoperative SurgeryAbstract
A range of corrective surgical procedures may be required in adult renal transplant recipients who sustain loss of integrity of the abdominal wall in the first month postoperatively. Where this involves the fascia, such as in acute fascial dehiscence or in renal allograft compartment syndrome, more sophisticated reconstructive procedures may also be required, particularly in the setting of surgical site infection. There is limited data on the use of prosthetic or biologic mesh for this type of scenario, where urgen [...] 1755 10515 |
Converting CO2 from a Harmful Gas to a Renewable Source of Matter and Energy: A ReviewAbstract
The emission of greenhouse gases, specifically CO2, has reached non-acceptable levels causing global warming with adverse effects. Owing to rigorous ongoing research, these harmful substances might be converted to beneficial sources. The main objective of this study was to review the most effective processes that might utilize carbon dioxide to produce various substances, chemicals, and energy. For this, different existing and projected short-term and long-term strategies have been presented and discussed. Specific [...] 1754 10074 |
Improving Diabetes Outcomes with a Multimodal Intervention for Less Advantaged Adults with Type 2 Diabetesby
Abstract
If proper self-management behaviors are not maintained, diabetes may lead to reduced quality of life (QoL), decreased engagement in everyday activities, disabling health complications, and even death. Less advantaged adults with limited income, lower education, and fewer resources find diabetes self-management (DSM) particularly challenging due to healthcare and social inequalities. DSM education is important to understanding diabetes-related behaviors and improving QoL. There are few evidence informed DSM educatio [...] 1753 10062 |
A Pilot Study of a School-Based Yoga and Mindfulness Program for GirlsAbstract
Schools have made commendable efforts to incorporate yoga and mindfulness programs to address the wellbeing of students; however, research on the efficacy of school-based yoga and mindfulness programs is still in its infancy, particularly with school-aged students at risk of developing externalizing disorders. Much of the research has also focused on evaluating interventions implemented by researchers, rather than evaluating those implemented by the school and its staff. The aim of this pilot study was to evaluate [...] 1753 10700 |
Sex and Gender Issues in Heart Transplantation1753 10245 |
Health Risks from Supposedly Remediated US Hazardous-Waste Sites: An Early-Warning SignalAbstract
Scientific data are almost nonexistent regarding the health-protectiveness of most hazardous-waste-site remediation. Given this data-gap, recently the World Health Organization (WHO) urged scientists to develop methods of "cost-efficient health surveillance" of toxics' cleanups, including any "illegal operations". Following WHO, this article's importance is to develop one such cost-efficient method. Given the assumption that remediators'-redevelopers' public misrepresentations of their cleanups' safety may warrant [...] 1752 10431 |
Physical Characterization of Solar Thermal Energy Storage (TES) Materials for Solar Dryers: Case of Volcanic Stone (Pozzolan) in Chadby
Abstract
Many sensible heat storage materials are regularly used as thermal energy storage (TES) systems to improve the efficiency of solar dryers. The present work focuses on the effects of the volume and particle sizes of a volcanic stone (pozzolan) for the same purpose. Samples soaked in matt black and without soaking were also considered. Heat charge and discharge tests were carried out by exposing the pozzolan contained in a solar collector of the direct solar dryer (DSD) and indirect solar dryer (ISD) to the sun. Char [...] 1752 8435 |
Neuroscience and its Contribution to Neuroeducation for Individuals with Autism Spectrum Disorderby
Abstract
With an increasing prevalence of children with Autism Spectrum Disorder (ASD) in schools, teachers are in need of different effective ways to educate these individuals who have distinctly different needs and modalities of experience. One area that has been explored is neuroeducation, or using findings from neuroscientific research to inform classroom practice. Neuroscientific findings appear to center on two main themes of neurological differences among children with ASD: sensory processing and emotional processing [...] 1752 13312 |
Autoimmunity in Autologous Islet Transplantationby
Abstract
Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet transplantation, AIT). Given that patients undergoing TP and AIT are traditionally assumed not to be at risk for the development of beta-cell autoimmunity, it is possible that th [...] 1752 9546 |
FISHing for Unstable Cellular Genomes in the Human BrainAbstract
The human brain has been repeatedly shown to exhibit intercellular/somatic genomic variations at the chromosomal level, which are involved in the neuronal diversity in health and disease. Brain-specific chromosomal mosaicism (aneuploidy) and chromosome instability play a role in the normal and pathological neurodevelopment, neurodegeneration and aging of the central nervous system. Regardless of achievements in somatic cell (single-cell) genomics, there is still no consensus on the amounts of chromosomally abnormal [...] 1751 9160 |
A Switched-Reluctance Motor Drive Powered by Switch-Mode Rectifier with Battery Energy Storage BufferAbstract
This paper presents a three-phase full-bridge boost switch-mode rectifier (SMR) fed switched-reluctance motor (SRM) drive with energy storage buffer. First, the power circuits and control schemes of the two power stages are properly designed. Except for having good line drawn power quality, the boostable DC-link voltage of the SRM drive can enhance the SRM driving performance in wide speed range. And the recovered regenerative braking energy can be sent back to the grid successfully. Then, a battery storage system [...] 1751 9508 |
Enzymatic Hydrolysis of Meat Waste for a Circular Economyby
Abstract
This work demonstrates the possibility of implementing a technology that allows profitable value to be drawn from the meat waste from retail stores. Protein hydrolysate, collagen and fatty acids were recovered from meat waste through enzymatic hydrolysis using a mixture of enzymes: a protease (Alcalase) and a lipase (Resinase). Enzymatic hydrolysis was studied by response surface methodology (RMS). Four independent variables were used to study the response variables. The analysis showed that all factors including p [...] 1750 11451 |
Parkinson’s Disease Motor and Non-Motor Features Accompanying Insomnia and Excessive Daytime Sleepiness Symptoms, a Large Population-Based Studyby
Abstract
Insomnia and excessive daytime sleepiness are the most common sleep disturbances in Parkinson’s disease. This study aims at better understanding how severity of PD motor and non-motor features and dopaminergic treatments contribute to these sleep symptoms in the first decade of PD. Data from a community-based cohort of PD patients was used to model cross-sectional PD-related risk factors for insomnia and EDS sleep scores using linear regression models adjusted for age, gender, and PD duration. Longitudinal changes [...] 1750 9830 |
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Open Access Short Communication Electrochemical Impedance Spectroscopic Studies of PHEV2 form-factor Lithium-ion Cells for Automotive ApplicationsAbstract
Prismatic PHEV2 form-factor lithium-ion cells with a nominal capacity of 25 Ah (as used for automotive applications) have been studied with electrochemical impedance spectroscopy (EIS). The data was evaluated using electrical equivalent circuits. Mathematical modeling, system identification, and the determination of model parameters of the lithium-ion cell were also carried out. While a study of the influence of temperature and state-of-charge (SOC) performed using pristine lithium-ion cells showed a nonlinear rela [...] 1748 10996 |
Endemic Mycoses and Cryptococcus in Solid Organ Transplant RecipientsAbstract
The endemic mycoses are an important cause of morbidity and mortality in transplant recipients. These fungal infections are notable for their dimorphic life cycle, specific geographic distributions, and typical infection via environmental exposure. Their nonspecific presentation can make diagnosis challenging. Because of their geographic associations, assessment of both donor and recipient history is critical in making an accurate and timely diagnosis. Coccidioides spp. are endemic to the southwestern United S [...] 1748 15467 |
Depression in the Elderly–Epidemiology, Diagnosis, Special Aspects, and Treatment OptionsAbstract
The prevalence of Late-life Depression (LLD) has been estimated between 10% and 15%. Therefore, it is a considerable worldwide problem. The psychopathology is not substantially different from that of depressive episodes in young adults but somatic complaints in combination with end-of-life perspective leave an imprint on emotional experience. The frequent suicidal tendency, especially in old unmated men, remains a particular challenge. It is important to combine psychiatric and somatic diagnostics using modern meth [...] 1747 12602 |
The “PRIMING, TIMING, MIMING” Model of Individualized Behavioural Care Planning for Residents with DementiaAbstract
The current paper introduces the “Priming/Timing/Miming” Model of Behavioural Care Planning for persons with Dementia. This simple heuristic provides a quick, easy and systematic way to select from the vast number of behavioural strategies offered in the BPSD literature and to organize these in a way that can be incorporated into an individualized Behaviour Care Plan to deliver personal care to persons with dementia and also to develop a larger plan of care. An entire care plan is captured on one double-sided sheet [...] 1746 13375 |
The Design, Development and Assessment of a Novel De-centralised IoT-Based Remote Monitoring of a Small-Scale Anaerobic Digester Networkby
Abstract
The implementation of community-level de-centralised anaerobic digestion (AD) systems offers a sustainable solution for organic waste management and energy provision, but there is currently a need for low-cost methods of system control and management at this scale. The problem becomes accentuated with increasing deployment, as greater complexities are created by the need to both monitor and control a wider network of smaller, community-scale plants. This paper describes research to design, deploy and test such a sy [...] 1746 13911 |
Benefits of Combined Liver Transplant: Protection or Tolerance?by
Abstract
The privileged liver, due to its immunological status, is referred to as a tolerogenic organ. However, this alone does not explain the introduction of tolerance after single or combined liver transplantation (kidney, heart, pancreas, and intestine); other factors, such as recipient’s age, donor’s hepatic volume, iron metabolism, biomarkers, or imprint of cytomegalovirus infection, appear to be involved in the identification of patients who are likely to be tolerant to their graft. All the afore-stated factors appea [...] 1746 10681 |
Diffuse Intrinsic Pontine Glioma: Translation of Genomic Knowledge to Clinical PracticeAbstract
Pediatric brain tumors account for approximately 25% of all cancers in children and are currently the leading cause of cancer-related deaths in the pediatric population with an estimated incidence of 5.14 cases per 100,000 person years [1]. Up to 10-15% of all pediatric brain tumors arise in the brainstem, with the majority of these classified as the diffuse intrinsic pontine glioma (DIPG) subtype [2]. The outcome of children with DIPG remains dismal with a median survival of <1 year. Owing to the unique locatio [...] 1745 12775 |
The Role of Surveillance Bronchoscopy Following a Lung Transplantationby
Abstract
Pulmonary transplantation (LuTx) is established as a treatment option for patients with end-stage lung diseases, such as chronic obstructive pulmonary disease, cystic fibrosis, interstitial lung disease, and pulmonary arterial hypertension. Acute rejection and infection are implicated as potential risk factors in developing complications such as bronchiolitis obliterans syndrome (BOS) and chronic rejection, leading to high morbidity and mortality rates after the LuTx. Thus, surveillance procedures after transplanta [...] 1745 15186 |
Net Zero UK – Generation and Energy Storage Requirements for the UK to Become Carbon Neutralby
Abstract
This paper sets out a quantified scenario for the UK to reach net zero carbon emissions. Wind and solar are the main energy sources and their intermittency is accommodated through hydrogen electrolysis, biogas from anaerobic digesters, and their combination into biomethane. Hydrogen and biomethane stocks are tracked. A daily energy balance model is presented, using the most recent recorded weather data-2017 to 2021. Long periods of low wind in 2021 indicated the necessary energy storage capacities, which were adjus [...] 1744 10219 |
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