by Noa Sylvetsky  , Chen Futeran Shahar  , Meir Frankel  and Gabriel Munter

Received: 01 April 2020;  Published: 02 July 2020;  doi: 10.21926/obm.geriatr.2003126

Hospitalists are at risk for vitamin D deficiency during their active years due to indoor working conditions and insufficient sunlight exposure. The impairment of bone mineral density (BMD) in this group has not been studied. A total of 50 male hospitalists aged ≥ 65 years were enrolled. Their BMD was measured at the femoral neck (FN), lumbar spine (LS), and distal radius (DR), and their medical history and risk factors were assessed through a detailed questionnaire. The FRAX® (Fracture risk assessment tool) [...]

by Rui Wang  , Dong Lin  , Minghuan Gao  , Linna Guo  , Tiesheng Li  and Minghua Liu

Received: 29 January 2022;  Published: 07 April 2022;  doi: 10.21926/cr.2202008

A series of novel Bi2MoO6/Ag/Ag2CrO4 heterostructure photocatalysts (denoted as BA-X, X = 1, 3, 5, 10) were synthesized using a coprecipitation method. These photocatalysts were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-vis spectroscopy, and X-ray photoelectron spectroscopy (XPS) and their photocatalytic properties were investigated. Compared with pure Bi2MoO6 or Ag2CrO4, BA-5 exhibited a higher photocatalytic property and broader light absorption. In addition, the surface pla [...]

by Éilish A. Burke  , Rachael Carroll  , Angela W. Ding  , Melisa Yaman  , J. Bernard Walsh  , Philip McCallion  and Mary McCarron

Received: 23 June 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104182

Globally between 30-40% of all osteoporotic fractures occur among men, with a quarter of all hip fractures, the most serious complication of osteoporosis, occurring in men. Among men of 50 years of age or older, osteoporotic fracture risk reaches an alarming 20%. What is of great concern is that associated mortality is greater among men when compared with women. For hip fractures specifically, mortality for men is two to three times that in women which may be attributed to the fact that osteoporosis is often consid [...]

by Lauren Curry  , Meghan Pike  , Mary Lynch  , Dana Marcon  and Jana Sawynok

Received: 01 April 2019;  Published: 28 June 2019;  doi: 10.21926/obm.icm.1902040

Background: Qigong, traditional Chinese mind-body practices, is currently receiving increasing attention with exploration of what it is and what it does. Common elements include postures and movement, attention to breathing, and mental instructions. There is a growing literature on the health benefits of qigong in chronic pain and other conditions, and an intervention that provides benefit in multiple domains is particularly important for clinical practice. In this report, we present a case series of six individual [...]

by Elysa Nensy Irawan  , Sandro Sitompul  , Ken-Ichiro Yamashita  and Goro Fujita

Received: 05 October 2022;  Published: 02 January 2023;  doi: 10.21926/jept.2301001

This research aims to know the effect of the Rotor Radius Ratio on the performance of the hybrid Vertical Axis Wind Turbine Savonius-Darrieus NREL S809 model using the Computational Fluid Dynamics method. Two-bladed Savonius is used as an internal rotor, and three-bladed Darrieus NREL S809 as an external rotor. Turbine model performance is analyzed through the value of the Moment Coefficient and Power Coefficient. The result shows that the increase in the Rotor Radius Ratio value causes an increase in the initial M [...]

by Renato Pol  , Tiziana Ruggiero  , Luisa Giaccone  , Davide Camisassa  , Andrea Spadafora  , Giulia Rivetti  , Marta Bezzi  and Stefano Carossa

Received: 14 June 2019;  Published: 21 October 2019;  doi: 10.21926/obm.transplant.1904088

Objective: Hematopoietic stem cells transplant (HSCT) requires being preceded by chemotherapy and radiotherapy. The neutropenia and thrombocytopenia which follows may be the possible cause of post-transplant complications. It is required that the patient undergoing transplantation is eradicated of any possible infectious focus. Currently, a uniform protocol for the oral management of these patients is unavailable. Methods: The approach for the dental management of each patient was designed as a more selective proto [...]

by Daria Armani  and Antonella Petri

Received: 16 June 2023;  Published: 08 November 2023;  doi: 10.21926/cr.2304026

This paper will present some sectors in which enzymes can replace traditional catalysts in poly(butylene-succinate) industry, emphasizing the green chemistry aspects associated with these newer strategies.

by Ana Teresa Rodrigues de Sousa  , Gustavo Coxev Wolski  , Max Filipe Silva Gonçalves  and Marcos Paulo Gomes Mol

Received: 16 May 2024;  Published: 21 October 2024;  doi: 10.21926/aeer.2404021

Using thermal treatment in the waste management process has advantages such as reducing volume and the possibility of energy recovery. There are several incineration technologies with different characteristics and potential. Incineration, however, requires efficient environmental control to reduce associated risks, such as the emission of harmful compounds. The paper aims to compare solid waste treatment processes in grate and fluidized bed incinerators based on technical and environmental characteristics. For this [...]

by Francesco Calvani  , Emanuele Bartoletti  , Giancarlo Folchitto  , Stefania Santini  , Michele Fontevecchia  and Alessandra Alhadeff

Received: 06 April 2020;  Published: 11 May 2020;  doi: 10.21926/rpm.2002011

Skin regeneration is a multidisciplinary topic that involves plastic surgery, aesthetics, and dermatology. In the last few years, several molecules have been used to prevent or delay the skin aging process. Recently, promising investigations on novel β-1,3/1,6-glucan-based treatments, associated with sodium hyaluronate, have demonstrated the induction of a naïve biological stimulus in soft tissues. Serum Revitalizing Face (Lot 00118a0051 of 11/19/2018 approved by the Italian Ministry of Health as a Medical Device-C [...]

by Katerina G. Oikonomou  and Sarah Taimur

Received: 14 February 2019;  Published: 17 June 2019;  doi: 10.21926/obm.transplant.1902066

In non-endemic regions of the world, human T-cell lymphotropic virus type-1 (HTLV-1) is an uncommon pathogen in the transplant host, but can be associated with significant morbidity and mortality. Careful assessment for risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timely recognition and management in the transplant host. The use of antiretroviral agents in the management of symptomatic disease due to HTLV-1 remains controversial [...]

by Rastislav Burda  , Viera Danielisová  and Jozef Burda

Received: 03 June 2019;  Published: 20 September 2019;  doi: 10.21926/obm.neurobiol.1903041

Background: Many experiments have been done to demonstrate robust ischemic tolerance efficiency using mostly young and healthy animals. However, the translation of these results to usually elderly and sick patients moreover taking many various medicines has to date been disappointing. 3-Methyltin (TMT) poisoning and short-term transient cerebral ischemia cause similar damage, especially, to selectively vulnerable brain regions such as hippocampal CA1 and CA3. Methods: Using dual conditioning, we activated the full [...]

by Vincenzo Prisco  , Bernadette Donnarumma  and Lorenzo Prisco

Received: 27 March 2020;  Published: 03 December 2020;  doi: 10.21926/obm.neurobiol.2004079

Anecdotal evidence suggests the possible association of psychiatric disorders with Mӧbius sequence, although the evidence is not conclusive. Intermittent presentation of auto-aggressive outbursts, in particular, could be related to Mӧbius sequence, different from the common psychotic symptoms. The present report describes the clinical case of a young man with Mӧbius syndrome who exhibited a complex representation of severe mental retardation and concomitant psychiatric disorders. Extremely rare psychiatric disorder [...]

by Katharina Tigges-Limmer  , Stephan Ensminger  , Yvonne Brocks  , Scott Stock Gissendanner  and Jan Gummert

Received: 28 October 2018;  Published: 05 March 2019;  doi: 10.21926/obm.transplant.1901056

Background: The participation of mental health professionals in multidisciplinary care teams for heart transplantation has become an international standard practice. The contribution of these professionals in this setting, which involves assessment and interventions, has not been the subject of systematic study. Methods: This paper explores how psychotherapists contribute to multidisciplinary decision making and care in transplant teams before, during, and after transplantation. To illustrate, it uses the case of a [...]

by Marianna Michałowska

Received: 11 June 2021;  Published: 18 October 2021;  doi: 10.21926/aeer.2104025

Since 1907, when Bakelite was invented, there has been a dramatic rise in the daily usage of plastic-like materials. Today, its negative impacts are a part of scientific studies and public debates. Art and artists play a significant role in these discussions. They mediate between the specialist content and public awareness. This study is dedicated to the artworks of artists using plastic waste collected from the seashore. I organized their works into three lines, within which artists have different threads of plast [...]

by Giuseppe Cocco

Received: 05 September 2020;  Published: 10 September 2020;  doi: 10.21926/obm.geriatr.2003132

Covid-19 pandemic has been infecting a substantial portion of the world population, thereby revealing quality deficits in health care in the majority of the countries around the globe. Severe illness and mortality from Covid-19 infection are present predominantly in minorities; especially they are more frequent in geriatric patients. Unfortunately, our knowledge is limited about what accounts for the variability in immune response from one person to another. This question is far from being merely academic, and find [...]

by Zachary Zeigler  , Jacob Lawrence  , Alexa Jamison  and Pete Salzano

Received: 02 August 2021;  Published: 02 September 2021;  doi: 10.21926/obm.icm.2103027

Statistical modeling indicated that COVID-19 would have afflicted more than 60% of the US population. Social distancing, self-quarantine, and widespread shutdowns were imposed. The push to stay at home and the decreased availability of exercise facilities have potentially reduced physical activity (PA). The purpose of this observational, correlational study was to determine if there is a relationship between PA level and symptoms of COVID-19. Subjects were asked to complete a single Survey Monkey questionnaire. The [...]

by Edwin Meresh  , David Daniels  , Jack H. Owens  , David Thompson  , Sarah Mennella  , Michael Levy  and Brenda Swartz

Received: 10 November 2019;  Published: 10 January 2020;  doi: 10.21926/obm.neurobiol.2001048

Agitation is a common manifestation of acute brain injury. When not addressed, agitation can lead to slower recovery rates, including delayed admission to acute rehabilitation programs. Antipsychotics are commonly used to control agitation in acute brain injury in the ICU. However, there is no current consensus on the most "efficacious and safest strategy" for use of antipsychotics in acute TBI. Haloperidol is arguably the commonly used antipsychotic for agitation in ICU setting at present. Interestingly, there are [...]

by Moira M. Ijzerman  , Amir B. Bazrgar  , Andrew M. Gordon  and Naresh V. Thevathasan

Received: 08 September 2022;  Published: 25 October 2022;  doi: 10.21926/aeer.2204043

Carbon (C) storage potential was quantified for four tree species which are commonly incorporated into tree-based intercropping (TBI) systems and compared with conventional agricultural systems in southern Ontario, Canada. In the 31-year-old TBI system at the University of Guelph's Agroforestry Research Station, Norway spruce (Picea abies), white cedar (Thuja occidentalis), black walnut (Juglans nigra) and red oak (Quercus rubra) were planted in tree rows, intercropped with soybean (Glycine max). In the conventiona [...]

by Joseph V. Pergolizzi, Jr.  and Jo Ann LeQuang

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

by Xiang-Yu Sun  , Ping-Hong Jhou  , Min-Ze Lu  and Chang-Ming Liaw

Received: 25 February 2021;  Published: 22 June 2021;  doi: 10.21926/jept.2102028

This paper presents the development of a wind Interior Permanent-Magnet Synchronous Generator (IPMSG) based bipolar DC microgrids along with various switch-mode rectifiers. Firstly, the wind IPMSG is established and adequately controlled to possess satisfactory generating characteristics during different driven speeds and loads. Later, the boost switch-mode rectifier (SMR) based bipolar DC bus is established. Further, three-phase single-switch (3P1SW) boost SMR, three-phase two-switch (3P2SW) three-level boost SMR, [...]

by Carine Vassy  , Laurence Brunet  and Christine Noiville

Received: 02 September 2021;  Published: 25 February 2022;  doi: 10.21926/obm.genet.2201149

This article examines the regulation of the screening of fetal abnormalities in France before and after the implementation of the new technique of non-invasive prenatal testing (NIPT) in 2013. In addition, this article evaluates the effectiveness of the regulatory framework in addressing the ethical and social issues raised by this technique from a legal and sociological perspective. The analysis reveals that the regulations, consistent with that applied to other prenatal screening techniques, fail to take proper a [...]

by Lina Nguyen  , Gabrielle Romena  , Ethan Nguyen  , Cassandra Tran  , Kaitlyn Nguyen  , Ananya Devarajan  and Henry Hirschberg

Received: 15 December 2020;  Published: 23 March 2021;  doi: 10.21926/obm.neurobiol.2101090

Following post-operative treatment, the vast majority of GBMs recur, usually within 2 cm of the tumor resection margin. Since these tumors seldom metastasize outside the CNS, improved localized therapies should prove beneficial. Drug delivery systems (DDS) that allow control over drug release by an externally applied energy, such as light, have the potential of improving the results of chemotherapy. Light-activated hydrogel DDS, implanted in the operative cavity formed by tumor resection, bypasses the blood brain b [...]

by Bernard Nicolardot  , Mae Guinet  , Anne-Sophie Voisin  and Catherine Hénault

Received: 26 January 2023;  Published: 26 April 2023;  doi: 10.21926/aeer.2302029

Legumes provide several ecological services to agroecosystems, but there is a lack of references on services related to N flows for a wide range of legume crops. N2O emissions were measured in two field experiments using a two-year legume-cereal crop sequence. In the first year (2014 and 2016), different legume crops were grown (lupin, pea, fava bean, common bean, soybean, chickpea) and compared to fertilized cereals (barley and sorghum). Once the seeds were harvested and the residues incorporated in the soil, unfe [...]

by Azra Shafi  and Qayyum Husain

Received: 06 August 2022;  Published: 17 November 2022;  doi: 10.21926/cr.2204040

Interpreting the relationship between the activity and structure of β-galactosidase is necessary to perceive the impact of the enzyme’s conformation on its catalysis. The current study thoroughly explains the effects of additives such as ethylenediaminetetraacetic acid (EDTA), sodium dodecyl sulfate (SDS), dithiothreitol (DTT), and urea on β-galactosidase activity and structure. β-Galactosidase activity was determined at various ionic strengths and temperatures as a function of time. Structural [...]

by Francesco E. Negro  and Francesco V. Marino

Received: 26 April 2021;  Published: 07 November 2021;  doi: 10.21926/obm.icm.2104045

The 19th century saw an explosion of serious epidemic diseases, such as smallpox and scarlet fever, which led to the development of an alternative system of medicine called homeopathy. Under this system, S. Hahnemann developed a rigorous methodology based on repeated observations on the field, leading to successful results. The aim of this work is to depict the birth and evolution of his thought. The correct understanding and application of this methodology became the reference model for subsequent generations of h [...]

by Omar Alelweet  and Sara Pavia

Received: 09 June 2021;  Published: 13 October 2021;  doi: 10.21926/rpm.2104041

Alkali activated (AA) materials have been investigated for decades as an alternative to Portland cement (PC) products. Most consist of a silicate waste activated with alkalis, which leads to lower green-house gas emissions and a substantial drop in the use of unrenewable material resources. This paper studies the durability of AA materials made with a ground granulated blast furnace slag (GGBS) from Dublin, activated with sodium hydroxide (NaOH), and sodium silicate (Na2SiO3), both combined and separately, and cure [...]

by Mariya Shiyko

Received: 17 July 2018;  Published: 08 November 2018;  doi: 10.21926/obm.icm.1804029

What is meditation? A tool that empowers you to create your life through working it from inside out, beginning with a thought. There is a story. A father had two sons: one felt a victim of life. He viewed his life through the prism of “My childhood was difficult. My father was an alcoholic. The reason my life is failing is because of that. I was not loved enough.” This is his inner mantra – a cycle of a repetitive thought patterns that he continuously told himself. His life followed that very mantra. He didn’t try [...]

by Jigar Jogia

Received: 17 April 2017;  Published: 09 July 2017;  doi: 10.21926/obm.neurobiol.1702006

There is a need for early diagnosis, monitoring and treatment of Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI). Traditional assessments of cognitive decline have been found to lack sensitivity and accuracy in differentiating varying stages of Dementia and cognitive decline as well as being time consuming in their administration. Key components of cognition namely memory and executive function have been identified as most predicative of AD status. Brief cognitive screening tools such as the Montreal C [...]

by Mônica Batista Leite  and Paulo Roberto Lopes Lima

Received: 07 March 2021;  Published: 28 July 2021;  doi: 10.21926/rpm.2103032

The production of concrete using recycled aggregates, obtained from the processing of construction and demolition waste, is extensively practiced worldwide. However, the effect of simultaneous adding fine recycled aggregate and the recycled coarse aggregate on the mechanical properties of concrete is still unfamiliar. This work aims to evaluate the influence of the water/cement ratio (WC Ratio), the fine recycled aggregate content (%FRA), the coarse recycled aggregate content (%CRA), as well as the interaction betw [...]

by Poppy L.A. Schoenberg

Received: 17 October 2023;  Published: 25 October 2023;  doi: 10.21926/obm.icm.2304046

The digital transformation of healthcare is accelerating. At the forefront of this revolution is the development of the "metaverse." This multidimensional digital universe, where virtual and physical realities converge, is reshaping the potential of integrative and complementary medicine. In this special edition journal series, we explore how metaverse technologies such as virtual reality, augmented reality, avatars, digital twins, blockchain smart contracts, and more, are poised to revolutionize holistic healthcar [...]

by Aarthi Madhavan  , Isaac Sia  , Giselle Carnaby  and Michael Crary

Received: 29 October 2020;  Published: 22 February 2021;  doi: 10.21926/obm.geriatr.2101158

Individuals with acute stroke on nonoral feeding regimens frequently develop pneumonia, questioning the long-held belief that pneumonia in stroke patients is a caused by food and liquid aspiration alone. Refluxate and colonized oral secretions are thought to contribute to an acidic oropharyngeal environment. If aspirated, these colonized oral secretions with increased acidity, can result in increased risk to the respiratory system. This study aimed to investigate the relationship between pharyngeal acidity, dysphag [...]

by Ganisetti Vijay Kumar  , Min-Ze Lu  and Chang-Ming Liaw

Received: 02 May 2021;  Published: 11 August 2021;  doi: 10.21926/jept.2103037

The development of high-efficiency motor drives for various applications is important in the industry 4.0 era, especially for their extensive application to electric vehicles (EVs). In this study, a position sensorless EV synchronous reluctance motor (SynRM) drive has been developed, which exhibits good driving performance and efficiency over a wide speed and load range. To solve the key problems popularly encountered in the existing approaches, the high-frequency injection (HFI) scheme based on q-axis injection ha [...]

by Keith D Hutchison  and Barbara Iisager

Received: 13 September 2020;  Published: 24 November 2020;  doi: 10.21926/aeer.2004004

The processes relevant to the verification of cloud forecasts generated by climate models are discussed from an engineering perspective. These processes include an assessment of cloud product requirements to be evaluated, the creation of a verification test plan including procedures and data to be analyzed, the development of independent sources of validation or truth datasets, and the quantitative comparisons between the cloud forecast products and the truth data needed to establish model performance. The engineer [...]

by Niamh Flynn

Received: 18 March 2021;  Published: 02 May 2021;  doi: 10.21926/obm.neurobiol.2102092

Although studies to understand the pathogenesis of migraines are in progress, no theory has adequately explained the etiology and pathophysiology of migraines to date. This has affected the development of treatment strategies for migraineurs. Currently, the pharmacological treatment for migraines provides both acute and prophylactic options to patients based on a biomedical model of pain. However, patients’ adherence to oral migraine preventive medication (OMPM) is poor, and their persistence is even lower when the [...]

by Mrudula Munagala  and Anita Phancao

Received: 31 August 2017;  Published: 11 January 2018;  doi: 10.21926/obm.transplant.1801007

Heart transplant remains the gold standard therapy for patients with end stage heart disease and offers improved survival and quality of life. Significant progress has been achieved in improving one-year mortality after heart transplantation. Nonetheless, long-term graft survival has not changed significantly over the past few decades. Long term survival of heart transplant recipients is limited by chronic rejection, cardiac allograft vasculopathy (CAV), and malignancy. CAV is a major contributor for graft failure [...]

by Elham Amjad  , Babak Sokouti  , Solmaz Asnaashari  and Siavoush Dastmalchi

Received: 29 August 2024;  Published: 17 December 2024;  doi: 10.21926/obm.genet.2404275

This systematic review examines the role of SnRK2 (Sucrose non-fermenting 1-Related protein Kinase 2) genes in Arabidopsis thaliana growth and responses to abiotic stresses. SnRK2 protein kinases are key components of abscisic acid (ABA) signaling and osmotic stress responses in plants. The review synthesizes findings from numerous studies on how different SnRK2 genes regulate Arabidopsis growth, development, and stress tolerance at various life stages. Key topics covered include SnRK2 functions under environmental [...]

by Max Oberste  , Sophia Sharma  and Philipp Zimmer

Received: 24 April 2019;  Published: 28 August 2019;  doi: 10.21926/obm.icm.1903052

This systematic review and meta-analysis investigated whether acute aerobic exercise improves subsequent set shifting performance in healthy young individuals. Potential moderation of studies’ methodological quality and exercise intensity, as well as the presence of small-study effect was also examined. Studies were identified using electronic databases Medline, PsycINFO, and SPORTDiscus, as well as references of recent meta-analyses and references of included studies. In total, 12 studies were included into [...]

by Rolf R. Gerhardts

Received: 11 November 2019;  Published: 17 March 2020;  doi: 10.21926/rpm.2001007

We summarize and discuss a self-consistent screening and magneto-transport theory, developed to understand the results of scanning-force-microscope experiments on the current distribution in a two-dimensional electron system (2DES), located in a narrow Hall bar under the conditions of the integer quantum Hall effect (IQHE) and its breakdown. The theory explains why, at low temperatures, at certain intervals of the applied perpendicular magnetic field, the current density is confined to “incompressible stripes” (ISs [...]

by Selin Galatalı  , Damla Ekin Özkaya  , Taner Mercan  and Ergun Kaya

Received: 27 July 2023;  Published: 19 October 2023;  doi: 10.21926/obm.genet.2304198

In the face of rapid population growth worldwide, humanity's need for plant and animal products is increasing. In this regard, the organizations in charge of production make production and consumption forecasts for the future and try to accelerate the work aimed at increasing production. There are various ways of increasing production. The first of these is the improvement of cultivation techniques, the expansion of irrigated agricultural areas, and the effective control of diseases and pests. The second is to find [...]

by Hsueh-Fen S. Kao  and Maria A. Amaya

Received: 19 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.geriatr.1903065

Background: In 2016, Hispanic/Latino (H/L) Americans made up 8% of the older population (≥65) and 22.9% of the oldest population (≥85) in the United States. It is projected that the older H/L population will grow to 21% by 2060. Currently the older H/L population depends primarily on their families for care. Methods: Review published caregiving models for older adults in H/L populations. Results: Gradual and inevitable acculturation of H/L caregivers to U.S. social customs, and the mutual relationship within the [...]

by Muayad Alali  , Michael Z. David  , Sandra A. Ham  , Danziger-Isakov LA  , Allison H. Bartlett  , Lindsay Petty  and Jennifer C. Pisano

Received: 27 November 2019;  Published: 21 February 2020;  doi: 10.21926/obm.transplant.2001102

Most studies of children with prolonged fever and neutropenia (PFN) have focused on invasive fungal disease (IFD) as the etiology of fever and not on other causes. Data are lacking regarding risk factors and adverse outcomes in pediatric cancer patients with PFN compared with those whose fevers resolve more rapidly. Retrospective medical record review was performed for all cancer patients with febrile neutropenia (FN) in the pediatric oncology unit at University of Chicago Medicine Comer Children’s Hospital f [...]

by Rafail Nikolaos Tasakis  , F. Nina Papavasiliou  and Rita Shaknovich

Received: 03 December 2018;  Published: 08 April 2019;  doi: 10.21926/obm.genet.1902072

Cancer development and progression is strongly associated with somatic mutations. From oncogenic hits that initiate the primary tumor formation to metastasis, the tumor mutational burden (TMB) plays a prominent role in the disease progression for the vast majority of cancer types. Not only are heterogeneous mutational loads or genetic heterogeneity causal to transcriptomic and proteomic discrepancies and to phenotypic diversity between individuals, they are also between tumor cells. But in addition to mutations, a [...]

by Mahdi Yousefi  , Scott Donne  , Shabnam Bahremand Abrasi  and Mohammad Yousefi

Received: 10 April 2023;  Published: 13 September 2023;  doi: 10.21926/jept.2303028

The thermal cracking of methane (TMC) is a significant reaction occurring above 850°C, which proceeds in two stages: non-isothermally and isothermally. However, most existing studies have focused on obtaining reaction rates under isothermal conditions [1], limiting their applicability to practical industrial reactor conditions. This novel research aims to determine the overall thermal decomposition rate of methane to hydrogen and carbon in adiabatic conditions, covering the range of unstable industrial reactor temp [...]

by Anthony J. Berdis

Received: 09 February 2021;  Published: 18 May 2021;  doi: 10.21926/obm.neurobiol.2102096

Glioblastoma multiforme (GBM) is an extremely malignant type of primary brain tumor that exhibits a high mortality rate. Current standard therapy involves surgery followed by radiation and treatment with the DNA-alkylating agent, temozolomide (TMZ). While TMZ treatment can extend post-operative survival, most patients develop resistance to TMZ which leads to a significant increase in mortality. At the molecular level, TMZ produces a variety of different DNA lesions including N7-methylguanine, N3-methyladenine, and [...]

by Jitu Mani Das  , Isha Behere  , Jnanendra Upadhyay  , Rajiv Borah  and Ganesh Ingavle

Received: 14 October 2022;  Published: 20 January 2025;  doi: 10.21926/obm.neurobiol.2501265

Regenerating injured nerves is difficult because they have little spontaneous regeneration potential. Advances in tissue engineering and regenerative medicine have emphasized the possibility of biomaterial-based methods for nerve healing. Natural protein-based biomaterials have benefits over synthetic ones, such as biocompatibility, non-immunogenicity, and biodegradability. Silk fibroin, generated from mulberry and non-mulberry silkworms, is especially promising because of its abundance, simplicity of processing in [...]

by Lisa M. Manderino  , Mary Beth Spitznagel  , Divya Yogi-Morren  , John P. Kirwan  , Sangeeta Kashyap  and John Gunstad

Received: 01 August 2018;  Published: 05 December 2018;  doi: 10.21926/obm.geriatr.1804023

Background: Type 2 diabetes (T2DM) and metabolic syndrome are linked to pathological changes in the brain and increased likelihood of cognitive impairment. 25-hydroxyvitamin D insufficiency is commonly found in this population and is associated with cognitive dysfunction in other patient groups. This preliminary study sought to examine whether 25-hydroxyvitamin D levels are is associated with cognitive deficits in this population. Methods: Twenty individuals with T2DM and metabolic syndrome (n = 20, aged 45 to 72) [...]

by Yiu Lin Wong  , Jialing Zhang  , Linda LD Zhong  , David Moher  and Zhaoxiang Bian

Received: 04 December 2023;  Published: 06 March 2024;  doi: 10.21926/obm.icm.2401018

The modified Jade Wind-Barrier formula (MJWB) may prevent the common cold in the elderly with a Qi-deficiency Constitution. Previously, no controlled trial evidence existed to illuminate the concept of “preventive treatment of disease” as outlined in the constitution theory of Traditional Chinese Medicine. This theory distinctly suggests that enhancing the Qi-deficiency Constitution and modulating its functional state can prevent the occurrence of the common cold. This controlled trial (ClinicalTrials.gov identifie [...]

by Yoko Moriyama  , Timothy Bolt  , Marilyn Luptak  and Nanako Tamiya

Received: 19 February 2019;  Published: 09 July 2019;  doi: 10.21926/obm.geriatr.1903061

Background: Many informal caregivers providing at-home care to older family members want to continue serving as the primary caregiver if they get sufficient support. A key service enabling continued at-home care is access to unplanned respite care facilities for temporary institutional care on short notice and in emergencies. Methods: This study used city government survey results on service user satisfaction with the Japanese Long-Term Care Insurance (LTCI) system for a mid-sized, Japanese city. From this a range [...]

by Agnes C. Nkele  , Imosobomeh L. Ikhioya  , Chinedu P. Chime  and Fabian I. Ezema

Received: 29 May 2023;  Published: 18 July 2023;  doi: 10.21926/jept.2303024

In recent times, renewable energy resources have been greatly researched because of the increasing concern to minimize global warming and meet energy demands. Energy storage systems have become useful tools for sustainability and meeting energy needs. Solar energy has proven in recent times to be the primary and most prevalent option due to its environmental friendliness, availability, and minimal pollution. Effective utilization of available energy resources has led to developing new alternative energy devices lik [...]

by Maria Alonso-González  , José Fernando Rubio-Valle  , Victor Perez-Puyana  , Mercedes Jiménez-Rosado  and Alberto Romero

Received: 01 November 2019;  Published: 26 February 2020;  doi: 10.21926/rpm.2001004

The present study deals with the development of scaffolds based on gelatin (G) and/or chitosan (CH) through modifications in the central processing method. This process consists of the fabrication of a hydrogel which is, then submitted to a freeze-drying stage. To compare the effects of the different modifications, the mechanical properties of the various systems were characterized, employing both dynamic compressive strain and frequency sweep tests. In addition, their porosity as well as the structure and fiber di [...]