by Robert Medina  , Akanksha Dave  , Candice Keogh  , Jordan Bartfield  , Franco Estenssoro  , Melissa Fraga  and Brandon Lucke-Wold

Received: 28 February 2025;  Published: 21 July 2025;  doi: 10.21926/obm.neurobiol.2503292

This review examines a multimodal approach that integrates advanced neuroimaging, biofluid biomarkers, and innovative rehabilitation strategies for the optimized diagnosis and recovery of traumatic brain injury (TBI). TBI remains a critical public health challenge due to its high incidence and diverse, long-lasting morbidities. Conventional diagnostic methods often lack the sensitivity to detect subtle injuries, and current prognostic models are limited by the heterogeneity of TBI. Emerging neuroimaging techniques, [...]

by Maria Irene Bellini  , Joseph Ayathamattam  and Paul Elliot Herbert

Received: 19 October 2018;  Published: 19 November 2018;  doi: 10.21926/obm.transplant.1804026

Obesity is on the rise and the number of end stage renal disease patients who are obese parallel this trend. There is no universally accepted guideline for wait-listing end stage renal disease obese patients in order to reduce surgical complications and improve survival of the kidney graft. Criteria for acceptance are variable among transplant centres, as do post-transplant policies. Careful risk assessment to maximise the benefits of the limited organ donor resource must be undertaken prior to waitlist an obese ki [...]

by Oleksandr Skrylnyk  , Emilie Courbon  , Nicolas Heymans  and Marc Frère

Received: 18 December 2020;  Published: 14 April 2021;  doi: 10.21926/jept.2102017

Hybrid solar thermal systems are considered to be a promising solution for delivering clean thermal energy for the building sector, especially while combining them with other renewable energy sources. Usually, solar energy production does not match the thermal energy demand, and hence the energy storage must be integrated. Thermochemical energy storage is adapted particularly to be used along with solar thermal applications. In this article, the design of the combined solar thermochemical energy storage system is p [...]

by Rui Wang  , Husain E. Ashkanani  , Bingyun Li  and Badie I. Morsi

Received: 01 August 2022;  Published: 13 October 2022;  doi: 10.21926/jept.2204033

A unique two-Pathways process using aqueous sodium glycinate for CO2 capture from a split flue gas stream emitted from 600 MWe post-combustion coal power plant was developed in Aspen Plus v.10. The split gas flow rate used was 44.75 ton/h and contained 0.0023 mol% SO2 and 13.33 mol% CO2. The process includes a washing unit, a CO2 absorption unit, a reverse osmosis unit, and a solvent regeneration unit or an ultrafiltration unit. The washing unit uses deionized water to completely remove SO2 and the CO2 absorption u [...]

by Paul Scriven

Received: 29 October 2018;  Published: 22 January 2019;  doi: 10.21926/obm.genet.1901061

United Kingdom guidelines recommend single embryo transfer (fresh or cryopreserved) in the first full assisted conception cycle for women under 40 years most at risk of having twins. Based on a recent randomized clinical trial for women aged 36 to 40 years, the hypothetical effect of preimplantation genetic testing for chromosome aneuploidy was extrapolated to single transfer of every morphologically transferable embryo available from a full cycle. Offering testing to every woman seems likely to result in fewer cli [...]

by Suman Lahkar  , Richa Brahma  and Swapan Kumar Dolui

Received: 15 September 2022;  Published: 04 January 2023;  doi: 10.21926/cr.2301002

The development of noble metal-free catalyst for hydrogen evolution reaction (HER) is the primary challenge in fuel production to replace fossil fuels. Here, we have synthesized Fe-doped TiO2/PANI nanocomposite via facile in situ polymerization method and studied its electrocatalytic activity towards HER. The composite catalyzes HER efficiently with an overpotential value of -180 mV vs. RHE in 0.5 M H2SO4 solution to achieve the current density of 10 mA cm-2 and also possesses unique stability of 8 h. However, a un [...]

by Galal Khamis  , Jun Chi  and Qingshun Zhao

Received: 12 January 2024;  Published: 18 June 2024;  doi: 10.21926/obm.genet.2402244

Tomato (Solanum lycopersicum), a family of Solanaceae, is an annual crop grown in fields and greenhouses. Tomato is the fourth-largest agricultural crop in the world, with a market value of more than $50 billion. Numerous attempts were conducted on the tomato for further improvement via in vitro regeneration and transformation. This study aims to establish in vitro multiplication, transformation, and gene editing systems in tomatoes by using cotyledon explants. Cotyledon explants were placed on the MS medium suppor [...]

by Ioannis Syros  and Xenia Anastassiou-Hadjicharalambous

Received: 19 October 2023;  Published: 15 July 2024;  doi: 10.21926/obm.neurobiol.2403231

Obsessive-Compulsive Disorder (OCD) is a prevalent child and adolescent psychiatric condition characterized by substantial functional impairments. Cognitive Behavioral Therapy (CBT) has emerged as the primary therapeutic approach for managing mild to moderate cases of OCD in children and adolescents. Significant advancements have been made in applying CBT specifically to this age group in the past decade. Exposure and response prevention (ERP) is a core therapeutic technique grounded in the principle that anxiety t [...]

by Morkoss M. Fakhry  , Asmaa R. Abdel-Hamed  , Noha M. Mesbah  , Dina M. Abo-Elmatty  , Mohamed M. Sayed-Ahmed  , Abdel-Moneim M. Osman  and Ola S. Ahmed

Received: 27 November 2023;  Published: 26 February 2024;  doi: 10.21926/obm.genet.2401215

Breast cancer (BC) is the most common cause of cancer-related death and is the malignancy most frequently diagnosed in females worldwide. BC incidence is predicted to continue increasing worldwide. Without interventions, annual new cases will reach over 3 million by 2030. Genetic abnormalities account for almost 70% of all BC cases worldwide. Biological pathways implicated include non-coding RNAs (ncRNAs). MiRNAs are small non-coding RNA molecules that play a role in post-transcriptional regulation of gene expressi [...]

by Karen Sermon

Received: 11 August 2017;  Published: 26 October 2017;  doi: 10.21926/obm.genet.1704009

The main aim of PGS has always been to improve IVF outcome, especially in patient groups assumed to have higher rates of chromosomally abnormal embryos, such as patients of advanced maternal age. In that sense, PGS is quite different from other types of screening as discussed in other papers in this issue.Today it bears no doubt that blastocysts found to be uniformly aneuploid in a biopsy will fail to implant, or worse, will implant and lead to a pregnancy and birth carrying a major chromosomal abnormality, such as [...]

by Herbert B. Allen

Received: 30 December 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001107

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. This current work will show putative and plausible individual pathways that were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta amyloid; this has been shown in v [...]

by Peter Leary  and Peter Malin

Received: 30 November 2020;  Published: 19 March 2021;  doi: 10.21926/jept.2101013

In interest of accurately modelling wellbore production in convective geothermal systems, we draw attention to two approaches to numerical simulation of crustal fluid flow. The historical "strong" approach simulates the fluid mass conservation condition on a localised finite difference mesh approximation to poroelastic continua. The more flexible "weak" approach globally enforces fluid mass conservation by in effect integrating over all numerical mesh cells. Strong formulation crustal flow simulation emerged from n [...]

by Fatima A. M. Lino  , Kamal A. R. Ismail  , Waldir A. Bizzo  , Lucas A. N. da Silva  and João P. S. Veiga

Received: 23 September 2024;  Published: 07 April 2025;  doi: 10.21926/aeer.2502017

Urbanization driven by industrialization and population growth amplifies food consumption and reinforces the need for more fuels and energy. However, the expansion of biofuels can impose risks on long-term food security. This paper examines potential alternative crops for energy generation and food production, including those used by family farmers and their associations, to decentralize energy production and utilization as a crucial pillar of the global energy transition. Cassava, corn, and sugar beet are the chos [...]

by Rosaria Ferreri  , Simonetta Bernardini  , Franco Cracolici  and Francesca Bechini

Received: 29 September 2018;  Published: 01 February 2019;  doi: 10.21926/obm.icm.1901008

Background: Complementary medicines (CM), including homeopathy, acupuncture, and traditional Chinese medicine, have been introduced for cancer patients undergoing chemotherapy and radiotherapy treatment in the Pitigliano Hospital Centre of Integrated Medicine in order to minimize the side effects of these treatments, which improves quality of life and adherence to conventional therapies. Methods: Cancer patients (240) were enrolled in an integrated care model offering a comprehensive protocol including homeopathy a [...]

by Hamidreza Shamsi  , Ehsan Haghi  , Manh-Kien Tran  , Sean Walker  , Kaamran Raahemifar  and Michael Fowler

Received: 11 March 2022;  Published: 25 December 2022;  doi: 10.21926/jept.2204043

Road traffic is a significant source of air pollution that has a harmful impact on human health. To reduce the health and environmental impacts of fossil fuel consumption in the transportation sector, many countries have implemented policies to promote the deployment of electric vehicles (EVs). A vital factor to consider when designing policies to support EV use is the monetized health impacts of fossil fuel consumption. This research aims to investigate the health benefit of replacing internal combustion engine ve [...]

by Rebecca MacDonald  and Anna Zumbansen

Received: 26 February 2023;  Published: 13 June 2023;  doi: 10.21926/obm.icm.2302024

Group singing as a social musical activity can be used to improve the quality of life, well-being, and overall health of people with dementia and caregivers. Online choirs have gained awareness since the COVID-19 pandemic; however, singing in an online choir is an unsatisfying experience for most choir members in the general population. In order to report on the feasibility of creating an online choir for people with dementia, we studied a successful case of such a choir. This choir began and continued online for o [...]

by Poppy L.A. Schoenberg  and Katlyn M. Gonzalez

Received: 27 March 2022;  Published: 05 December 2022;  doi: 10.21926/obm.icm.2204052

The multi-dimensional measurement of complex biological systems and sub-systems is made possible by high-dimensional omics technologies. This frontier of research is promising for elucidating disease processes, physiological parameters, and therapeutic action mechanisms. Omics have potential merit for the integrative medicine field that is relatively early in terms of mechanistic research towards understanding the underlining therapeutic processes of mind-body interventions that show to affect multiple systems simu [...]

by Anju Khairwa

Received: 14 September 2022;  Published: 22 November 2022;  doi: 10.21926/obm.genet.2204172

Cervical carcinoma is most common in Indian women of which Rural women are predominantly affected. The most common etiological factor is human papillomavirus (HPV ). The present study aims to assess the diagnostic accuracy, sensitivity, specificity, and different patterns of cervical Pap smears by comparing histological findings. The index study is a retrospective cross-sectional analytical study. The data was collected at the pathology department from May 2017 to December 2019 according to hospital ethical protoco [...]

by Mingyu Wang  , Jie Liu  , Jinpeng Li  and Tiesheng Li

Received: 21 March 2022;  Published: 14 April 2022;  doi: 10.21926/cr.2202010

A new chiral cyclopalladated ferrocenyl imine catalyst (called 4a2) was designed and synthesized, and its self-assembly catalytic polymeric brush supported on silicon (denoted as Si@PB4a2) was also fabricated by surface-initiated atom transfer radical polymerization (ATRP) and characterized. The catalytic properties of monomer 4a2 in homogeneous and Si@PB4a2 in heterogeneous in Heck and Suzuki cross-coupling were investigated, respectively. They exhibited higher catalytic activity in Heck, and Suzuki coupling react [...]

by Whitney Rabacal  , Emily Rayens  and Karen Norris

Received: 02 November 2018;  Published: 27 December 2018;  doi: 10.21926/obm.genet.1804057

Pneumocystis causes life-threatening pneumonia in immunocompromised populations. More recently it has been implicated as a co-factor in a number of chronic lung diseases including chronic obstructive pulmonary disease (COPD), severe asthma, and cystic fibrosis (CF). In this review, we will examine the current literature regarding Pneumocystis and lung diseases in the HIV-infected patients and non-HIV immunocompromised populations, and the barriers to prophylaxis and treatment in these patients. Trimethoprim sulfame [...]

by Irina Udina  , Yurii Vasiliev  , Vladimir Volobuyev  , Olga Gulenko  and Alesya Gracheva

Received: 24 December 2021;  Published: 27 June 2022;  doi: 10.21926/obm.genet.2202158

In this study, we investigated VNTR polymorphisms in intron 2 of the IL1RN gene (rs2234663) and intron 3 of the IL4 gene (rs8179190) related to the development of caries in school children (N = 196) with mixed bite dentition from Krasnodarskii Krai. The genotypes A1/A1 and L/L (L-"long" alleles) (rs2234663) provided resistance to the most intensive form of dental caries. The groups of children with DFC (decompensated form of caries) were significantly different from the pooled group SFC (subcompensated form of cari [...]

by Ashley Rosenberg  , Gilles Dongmo  , Pallavi Yadav  , Nathaniel Lee  and Kunal Yadav

Received: 13 August 2018;  Published: 21 September 2018;  doi: 10.21926/obm.transplant.1803020

Even though renal ectopia is common, there have been very few reports of these kidneys being used for transplantation. The concerns with using such kidneys are subnormal function, ureteral anomalies and complications and anomalous arterial supply which makes arterial reconstruction challenging. Majority of reports are for use in living donor transplantation where good preoperative imaging is available. There is very scant literature reporting use of ectopic pelvic kidneys from deceased donors. We report a case of a [...]

by Toshiaki Suzuki  , Makiko Tani  , Kaito Takamori  and Maki Yamada

Received: 21 January 2017;  Published: 20 February 2017;  doi: 10.21926/obm.icm.1701001

(1) Background: Acupoint stimulation physical therapy (ASPT) is a novel method of physical therapy that combines physical and acupuncture methods. This study aimed to examine the effect of ASPT in three hemiplegic patients with cerebrovascular disease using F-wave as a measure of the excitability of spinal neural function. (2) Methods: Subjects included three hemiplegic patients with cerebrovascular disease who presented with three types of neurological findings. All patients had moderate hypertonic muscles on the [...]

by Athina Chasapi  , Konstantinos Balampanis  , Anna Tanoglidi  , Eleni Kourea  , George I. Lambrou  , Vaia Lambadiari  , Fotios Kalfarentzos  , Erifili Hatziagelaki  , Maria Melachrinou  and Georgia Sotiropoulou-Bonikou

Received: 28 January 2019;  Published: 22 May 2019;  doi: 10.21926/obm.hg.1902020

(1) Background: A great number of inflammatory mediators and metabolic biomarkers have been shown to contribute to the development and progression of obesity-induced pathologies, including insulin resistance and nonalcoholic fatty liver disease (NAFLD). Many of those mediators are either targets or activators of nuclear factor-κappa B (NF-κB), which is a key transcription factor and plays a pivotal role in the homeostasis and the regulation of inflammatory signaling pathways in the liver. (2) Methods: Our study po [...]

by James Hackley  , Alison Dixon  , Carol Royle  , Christopher Moss  , Richard Brown  and Tobyn Bell

Received: 29 January 2024;  Published: 27 March 2024;  doi: 10.21926/obm.icm.2401021

Compassion-focused chairwork has become a recent focus of empirical investigation. This study extended this area of research by exploring how participants with depression experienced the ‘compassionate other’ imagery exercise enacted via chairwork methods. Eight individuals from primary care NHS mental health services were interviewed about their experience of the practice. The resultant data were analysed using interpretive phenomenological analysis (IPA). Three group experiential themes were identified: care that [...]