by Paul Scriven

Received: 29 October 2018;  Published: 22 January 2019;  doi: 10.21926/obm.genet.1901061

United Kingdom guidelines recommend single embryo transfer (fresh or cryopreserved) in the first full assisted conception cycle for women under 40 years most at risk of having twins. Based on a recent randomized clinical trial for women aged 36 to 40 years, the hypothetical effect of preimplantation genetic testing for chromosome aneuploidy was extrapolated to single transfer of every morphologically transferable embryo available from a full cycle. Offering testing to every woman seems likely to result in fewer cli [...]

by Herbert B. Allen

Received: 30 December 2019;  Published: 19 February 2020;  doi: 10.21926/obm.geriatr.2001107

A pathway which highlighted spirochetes (Borrelia burgdorferi and dental treponemes) that made biofilms which led to Alzheimer’s disease has recently been promulgated. All the Alzheimer’s disease, on which this pathway was based, had been specifically confirmed both clinically and pathologically. This current work will show putative and plausible individual pathways that were studied. First and foremost, intracellular spirochetes make biofilms and concurrently make beta amyloid; this has been shown in v [...]

by Anita Padmanabhanunni  , Serena Ann Isaacs  , Tyrone Pretorius  and Brendon Faroa

Received: 30 April 2022;  Published: 15 August 2022;  doi: 10.21926/obm.neurobiol.2203130

Fear has been the most common emotional response to the COVID-19 pandemic, and excessive fear is associated with various indices of psychological distress, particularly loneliness. Although most people have experienced pandemic-related fear and distress, certain groups who are on the front of service provision have experienced the pandemic in distinct ways, owing to its impact on the nature of their work. Schoolteachers represent one such group; therefore, it is imperative to identify resources that can safeguard a [...]

by Jie Zhang  , Jichao Wang  , Jill M. Norvilitis  and Wanting Fang

Received: 11 March 2024;  Published: 23 August 2024;  doi: 10.21926/obm.geriatr.2403285

This paper examines whether different types of intergenerational support have different effects on life satisfaction among the elderly, and whether a gender difference exists in the effect of intergenerational support on the elderly’s life satisfaction. Data from the China Longitudinal Aging Social Survey (CLASS) were used for this study. The study sample consisted of 10,801 cases. A logit regression model was used for empirical verification. All types of intergenerational support were found to have effects on life [...]

by Sai Vamsi Krishna Vissa  and Mileva Radonjic

Received: 21 March 2022;  Published: 29 April 2022;  doi: 10.21926/aeer.2202017

Oil and gas wellbores that are drilled into the earth’s crust need to be plugged and abandoned, to restore the geological seals once they are no longer producing. The main aim of Plugging and abandonment (P&A) is to ensure that there is no leakage of hydrocarbons into the environment. Since offshore P&A is challenging due to subsurface temperature and pressure conditions, testing zeolite as an additive for improvement of cement properties is an intriguing research topic. This initial research aims to [...]

by Toshiaki Suzuki  , Makiko Tani  , Kaito Takamori  and Maki Yamada

Received: 21 January 2017;  Published: 20 February 2017;  doi: 10.21926/obm.icm.1701001

(1) Background: Acupoint stimulation physical therapy (ASPT) is a novel method of physical therapy that combines physical and acupuncture methods. This study aimed to examine the effect of ASPT in three hemiplegic patients with cerebrovascular disease using F-wave as a measure of the excitability of spinal neural function. (2) Methods: Subjects included three hemiplegic patients with cerebrovascular disease who presented with three types of neurological findings. All patients had moderate hypertonic muscles on the [...]

by Shikah Almobayed  and Andrew Smith

Received: 24 October 2022;  Published: 06 March 2023;  doi: 10.21926/rpn.2301005

Health-related behaviours (HRBs) have been considered one of the most critical public health issues, especially for those with special educational needs (SEN). Previous research suggests that health-related behaviours are highly likely to impact well-being and academic achievement. Diet is a crucial health-related behaviour that needs to be investigated along with factors such as sleep and exercise. The present study used data from the Cornish Academies Project, and secondary analyses were conducted to investigate [...]

by Inmaculada Zarzo  , Nadia San Onofre  and Jose M. Soriano

Received: 17 November 2023;  Published: 03 April 2024;  doi: 10.21926/rpn.2402005

The relationship between obesity and weight loss treatments has run parallel throughout history; however, not all diets are suitable for improving one’s health. This review aims to categorize diets according to the new classification of hazardous diets established in 2021. A search was conducted across grey, white, and black literature. The results reveal a study of 179 diets, of which 35 are effective, while the rest are hazardous to health. Looking at the geographical distribution of these diets, the USA, the UK, [...]

by Oswaldo Núñez  , Mohammad Fereidooni  , Victor Márquez  , Duangthip Sattayamuk  , Piyasan Praserthdam  and Supareak Praserthdam

Received: 25 August 2023;  Published: 05 December 2023;  doi: 10.21926/cr.2304029

To improve CH4 and H2 formation from CO2 photoreduction using non-organic, non-laborious, and inexpensive photocatalysts, we have prepared two surface-silicate-modified TiO2 catalysts: P25-SiO2 and AmTiO2-SiO2 (amorphous TiO2) to be tested in water and using UV light. The last catalyst produces more CH4 and H2 in water than P25 (3:1 TiO2 anatase: rutile) under UV light irradiation of HCO3- and CO2; am-TiO2-SiO2 at pH = 7, produces 8 times more CH4 and H2 than P25 with selectivity at the reactor headspace of 30% and [...]

by Diana Eréndira Lara-Llanderal  , Juan Carlos Castro Dominguez  and Karla Graciela Cedano Villavicencio

Received: 02 September 2024;  Published: 07 February 2025;  doi: 10.21926/aeer.2501010

This article explores a strategy to empower vulnerable communities by transferring solar technology as a path to energy justice development. The proposed methodology is based on preliminary research on energy uses according to the needs, practices, and customs of the communities. The study focuses on the cases of three women with productive vocations based on entrepreneurship in different phases of incubation found in a peri-urban community in central Mexico. In this community, productive energy uses include a) the [...]

by Solaf Alaakel  and Youssef. AL-Ammouri

Received: 29 July 2023;  Published: 26 October 2023;  doi: 10.21926/obm.genet.2304200

The experiment was carried out at the laboratories of the National Commission for Biotechnology in Syria during the period 2020-2022 to detect the somaclonal genetic variation occurring in callus cultures at different ages and to compare them with the In vitro growing plants and introduced species of Rose Periwinkle that grew up in the Syrian environment, in addition, exploring the effect of abiotic stresses in causing genetic variations in callus, by the Inter Simple Sequence Repeats technique (ISSR) using 21 prim [...]

by Joana Sousa

Received: 15 May 2023;  Published: 15 January 2024;  doi: 10.21926/aeer.2401003

The climate change and the social crisis launched the basis for the policy discussion about future trajectories of development and sustainability. Innovation policies are expected to promote the transformation of complex socio-technical systems and call for fundamentally different societal production and consumption patterns. This is strictly associated with energy systems and energy policies. A policy framework was conceptualized considering three levels approach: the policy shape at the micro level, the policy co [...]

by Tammy Lennox  and Angela Kennedy

Received: 08 February 2022;  Published: 20 July 2023;  doi: 10.21926/obm.icm.2303030

The current article describes the application of the Compassion Focussed (CF) formulation to the interaction between individuals and their social context. The standard CF formulation [1] would see the person’s fears as inadvertently reinforced by their attempts to cope with the underlying issue. However, sometimes such attempts to cope can also reinforce the fears of another person or party. Interpersonal CF formulations could provide a compassionate, non-blaming way of enlightening people in their interactions to [...]

by Nicholas J. Geraghty  , Amal Elhage  , Peter Cuthbertson  , Debbie Watson  and Ronald Sluyter

Received: 06 June 2022;  Published: 06 September 2022;  doi: 10.21926/obm.transplant.2203166

Allogeneic hematopoietic stem cell transplantation is a curative therapy for hematological malignancies, but its efficacy is limited by graft-versus-host disease (GVHD). This life-threatening disorder develops when donor (graft) immune cells cause inflammatory damage to recipient (host) tissues. The immune cell receptor channel P2X7 and its ligand adenosine 5’-triphosphate (ATP) have been implicated in GVHD pathogenesis. Therefore, this signaling axis represents a potential therapeutic target. This study aime [...]

by Gilda F. Pardey Bracho  , Karine Collomb  and Astrig Topouzkhanian

Received: 09 May 2022;  Published: 28 July 2022;  doi: 10.21926/obm.icm.2203030

The patient as the custodian of their own care is a concept that has been evolving for several years and can help the patient to a better and quicker recovery. Medical Hypnosis (MH) assist the practitioner to reduce the patient’s pain and disorders and help the patient to understand, accept, and manage their situation. Recently, this technique has been increasingly used in awake surgery protocols. This paper describes three examples of the successful perioperative management of patients who benefited from an awake [...]

by Regiani Aparecida de Almeida  , Ricardo Vicente de Paula Rezende  , Flavia Aparecida Reitz Cardoso  and Lucio Cardozo Filho

Received: 17 December 2022;  Published: 18 April 2023;  doi: 10.21926/jept.2302016

In this work with CFD simulations, the evaluation of the supercritical anti-solvent (SAS) process for producing nanoparticles from an expanded solution of ethanol/solute in carbon dioxide is reported. The influence of the solution and antisolvent flow rates on mean particle size, the flow dynamic, and the supercritical mixture's jet velocity must be well established in the literature and analyzed. The high flow rate of the anti-solvent resulted in increased mean particle sizes for all studied cases. At the lowe [...]

by Gerhard Litscher

Received: 14 May 2024;  Published: 15 May 2024;  doi: 10.21926/obm.icm.2402027

Laser acupuncture, a rising complementary therapy, applies a low-intensity laser to acupuncture points, yet its underlying mechanisms remain unclear. Proposed hypotheses include modulation of cellular signaling, tissue repair, and immune modulation. Laser acupuncture may stimulate energy flow, neurotransmitter release, cellular changes, immune regulation, and neuroendocrine activity. Additionally, the biophoton theory suggests an involvement of ultra-weak photon radiation from cells. Litscher et al. explore these m [...]

by Joseph S. D'Arrigo

Received: 22 August 2019;  Published: 16 September 2019;  doi: 10.21926/obm.neurobiol.1903040

Microvascular endothelial dysfunction precedes, often by decades, the cognitive decline associated with Alzheimer's disease. Hence, preservation of a healthy cerebrovascular endothelium can be an important therapeutic target. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, mainly class B type I (i.e., SR-BI), and crosses the blood-brain barrier. Documented similarities in [...]

by Takeshi Hatta  , Taketoshi Hatta  , Junko Hatta  , Akihiko Iwahara  , Kazumi Fujiwara  , Kimiko Kato  and Yukiharu Hasegawa

Received: 15 October 2021;  Published: 24 February 2022;  doi: 10.21926/obm.geriatr.2201190

In the present study, we identified the factors of cognitive and physical performances predicting self-rated health perception (SRH) using an SRH questionnaire in 660 (298 men and 362 women) upper-middle-aged community dwellers. In addition, neuropsychological test battery and physical ability tests were applied. A multiple regression analysis was conducted using the forced entry method; digit cancellation test (D-CAT1), logical memory test, verbal fluency test, back strength, timed-up and-go (TUG), balancing test, [...]

by Chaimae Merimi  , Abdessamad Benabbou  , Lamiae Bourassi  , Abdelhay Addous  , Ahmed A. Elhenawy  , Rachid Touzani  and Belkheir Hammouti

Received: 22 January 2025;  Published: 25 June 2025;  doi: 10.21926/obm.icm.2502027

Cardiovascular diseases and hypertension represent significant global health challenges, driving the need for innovative therapeutic solutions. In this study, we employed advanced in silico methods to investigate the molecular properties of two bioactive compounds, Flavonoids and Rosmarinic Acid, extracted from five medicinal plants: Rosemary, Oregano, Pink Savory, Lemon Balm, and Saffron. The bioactive compounds were evaluated against key biological targets associated with hypertension and cardiovascular diseases, [...]

by Yuri B. Yurov  , Svetlana G. Vorsanova  and Ivan Y. Iourov

Received: 06 February 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902076

The human brain has been repeatedly shown to exhibit intercellular/somatic genomic variations at the chromosomal level, which are involved in the neuronal diversity in health and disease. Brain-specific chromosomal mosaicism (aneuploidy) and chromosome instability play a role in the normal and pathological neurodevelopment, neurodegeneration and aging of the central nervous system. Regardless of achievements in somatic cell (single-cell) genomics, there is still no consensus on the amounts of chromosomally abnormal [...]

by Carsten Croonenbroeck  and David Hennecke

Received: 20 July 2021;  Published: 25 October 2021;  doi: 10.21926/jept.2104044

In this study, we address the wind farm layout optimization (WFLO) problem and tackle the issue of optimal turbine placement by incorporating additional aspects of an economically driven target function. Firstly, we have analyzed the effect of wind direction on a given turbine arrangement. Based on the direction-dependent wake pattern, practitioners sometimes shut down certain turbines on their farms. Our method computes which turbines should be shut down in which wake situation. On this basis, we have developed a [...]

by Clément Dumont  , Madeleine Lefèvre  , Quiterie Aussedat  , Pierre-Louis Régnier  , Alexandra Masson-Lecomte  , Evanguelos Xylinas  , Hélène Gauthier  , Virginie Fossey-Diaz  , Amélie Arégui  and Stéphane Culine

Received: 23 July 2021;  Published: 08 November 2021;  doi: 10.21926/obm.geriatr.2104183

Cisplatin-based neoadjuvant chemotherapy (C-NAC) has been the standard of care in localized muscle-invasive bladder cancer (MIBC). However, the feasibility and benefit of C-NAC in elderly patients remain uncertain since this population has always been underrepresented in pivotal trials and is often barred from chemotherapy in routine practice because of their perceived frailty. Therefore, in order to evaluate the effectiveness of C-NAC in elderly patients with MIBS, we retrospectively reviewed the medical files of [...]

by Patricia Lynn Dobkin

Received: 14 May 2019;  Published: 07 August 2019;  doi: 10.21926/obm.icm.1903050

The author writes a genuine story using a narrative medicine writing style [1]. She relates how she applied mindfulness awareness and meditation practices to accompany her best friend, Abigail (Abigail is a pseudonym), who struggled through stages 3 and 4 breast cancer, including its noxious treatments and upsetting side effects. Clinical practice can be enhanced with narrative competence in that it helps the author recognize, interpret and be touched by patients’ stories, including all aspects of illness experienc [...]

by Naoaki Sakata  , Gumpei Yoshimatsu  and Shohta Kodama

Received: 15 January 2019;  Published: 03 April 2019;  doi: 10.21926/obm.transplant.1902059

Total pancreatectomy (TP) is performed for not only malignant pancreatic diseases but also benign disease such as chronic pancreatitis or pancreatic injury. However, because this surgery involves removal of the whole pancreas, both exocrine and endocrine pancreatic functions are abolished, significantly impairing the nutritional statuses of patients as well as having other detrimental outcomes. Thus, especially in benign cases additional treatment to recover endocrine function is recommended, as permanent endocrine [...]