by Georgia Kakourou  , Thalia Mamas  , Christina Vrettou  and Jan Traeger-Synodinos

Received: 03 June 2019;  Published: 22 July 2019;  doi: 10.21926/obm.genet.1903084

Preimplantation Genetic Testing for HLA-matching (PGT-HLA) has been one of the most controversial PGT applications, first reported in 2001. The procedure aims to identify an embryo that is not only healthy but also HLA-matched with a sibling in the family in need of haematopoietic stem cell transplantation (HSCT), considering that sibling HSCT stands the highest chance of success in comparison to alternative approaches. HLA-typing can be performed with or without PGT-M for the exclusion of a single-gene disorder. T [...]

by Katarina Mark  and Maria Arman

Received: 09 June 2018;  Published: 27 November 2018;  doi: 10.21926/obm.icm.1804031

Background: People suffering from multiple sclerosis (MS) commonly use complementary and alternative medicine due to the partial efficacy of conventional treatments, the chronic aspect of MS, the impact of pain and the side-effects of medication. An exploratory descriptive study of three cases was performed to document and analyse the experience patients treated for MS with applied kinesiology. Methods: Qualitative interviews were conducted with three patients who had been diagnosed with MS at the Neurology Departm [...]

by Kamal A.R. Ismail  , Fatima A.M Lino  , Jorge R. Henriquez  , Mohamed Teggar  , Abdelghani Laouer  , Muslum Arici  , Amani Benhorma  and Daniel Rodríguez

Received: 12 June 2023;  Published: 19 October 2023;  doi: 10.21926/jept.2304031

The building sector is rated as a big consumer of electric energy and emissions, responsible for about 40% of final electric energy consumption. As a result, the Paris Agreement 2015 set a goal for buildings and the construction sector to reach a nearly zero-carbon stage by 2050. This urged most countries to create regulations for the construction sector and invest in energy efficiency programs. The present paper aims to present an updated review of building energy-saving solutions and techniques to contribute to c [...]

by Kazuki Mochizuki  , Chihiro Imai  , Noriko Sato  and Takeo Kubota

Received: 20 June 2017;  Published: 19 October 2017;  doi: 10.21926/obm.genet.1704008

A number of epidemiological studies have suggested that environmental stresses, such as malnutrition during the fetal period, can induce development of metabolic disorders, such as obesity, type 2 diabetes, and hypertension, and and even psychiatric disorders in later life. This theory model is known as the Developmental Origins of Health and Disease (DOHaD) theory, in which postulates that “epigenetic memories”, involving DNA methylation, histone modifications and microRNA expression, are induced by environmental [...]

by Mahintaj Dara  , Mehdi Dianatpour  , Negar Azarpira  and Nader Tanideh

Received: 04 September 2024;  Published: 08 January 2025;  doi: 10.21926/obm.genet.2501280

Gene therapy, a groundbreaking method for addressing genetic mutations, includes strategies such as gene repair, replacement, inactivation, or the introduction of therapeutic genes, circumventing traditional surgical or pharmacological approaches. Delivery through viral or non-viral vectors presents trade-offs in efficiency and immune response. Recent gene-editing technologies like ZFNs, TALENs, and CRISPR facilitate precise genome modifications by inducing targeted double-strand breaks, with CRISPR/Cas9 recognized [...]

by Mrutyunjay Padhiary  , Pankaj Roy  and Kundan Kumar

Received: 26 August 2024;  Published: 01 April 2025;  doi: 10.21926/rpse.2502006

Precision agriculture depends on the automation and mechanization of agricultural equipment and vehicles in a variety of terrains, which increases productivity and sustainability. This review presents a comparative analysis of significant simulation software used in designing and developing automated agricultural systems, emphasizing their methodologies and significance in advancing farm technology. Artificial intelligence (AI) and machine learning (ML) methods are modeled, optimized, and integrated using key techn [...]

by Mojtaba Ehsanifar  and Zeinab Yavari

Received: 13 December 2024;  Published: 16 March 2025;  doi: 10.21926/obm.neurobiol.2501277

The pervasive presence and enduring existence of micro and nanoplastics in the environment render their exposure to humans and aquatic creatures unavoidable. Research indicates these tiny plastic particles can be taken in by aquatic beings and mammals. Once within the body, micro and nanoplastics have the capability to infiltrate the brain, although the level of penetration and the subsequent neurotoxic effects are not fully explored. Previous studies indicate that metal (oxide) nanoparticles can enter the brain an [...]

by Hadi Heidari  and Neil S Grigg

Received: 27 May 2021;  Published: 30 August 2021;  doi: 10.21926/aeer.2103021

The coronavirus disease 2019 (COVID-19) is a global crisis spreading to all countries. This study explains and documents the first-order effects of the new coronavirus on the urban water cycle. Urban water systems play an important role in public health because people rely so heavily on water services. Findings address short- and long-term changes in climate variables; availability and accessibility of clean water to prevent and control the spread of coronavirus in water-scarce cities; shifts in habits, behavior, a [...]

by Emily Smith Schafer

Received: 02 March 2023;  Published: 24 May 2024;  doi: 10.21926/obm.icm.2402030

According to the National Survey of Children’s Health (NSCH), nearly 30 million children in the United States have experienced one or more types of significant childhood trauma. In the average public school, this statistic translates to as many as half of the students in a given teacher’s classroom. Children exposed to the toxic stress of trauma often experience negative consequences that affect their academic, psychological, socioemotional, and behavioral health. To aid educators in addressing this reality, trauma [...]

by Mathivathani Kandiah  , Dharsha Bhaskaran  and Ominda Perera

Received: 29 April 2024;  Published: 22 July 2024;  doi: 10.21926/cr.2403010

Nanotechnology is a fast-rising market in catalytic research; however, the production of eco-friendly nanoparticles remains a significant challenge. In this study, silver nanoparticles (AgNPs) were synthesized from the agro-industrial waste of leaves of C. longa, C. aromatica, C. caesia, C. zedoaria, and C. amada at RT after 24 h, which was confirmed with UV-spectrophotometric evaluation between 320-520 nm. SEM revealed cubic and 30-50 nm AgNPs, while band-gap energy was presented as semi-conductors. Synthesized Ag [...]

by Emma Wolverson  , Heather Birtles  , Esme Moniz-Cook  , Ian James  , Dawn Brooker  and Frances Duffy

Received: 08 September 2019;  Published: 11 October 2019;  doi: 10.21926/obm.geriatr.1904080

Background: Behavioural and Psychological Symptoms of Dementia and Challenging Behaviour in dementia are just two of a variety of terms for a complex paradigm that covers the most distressing and costly aspects of the condition. The terminology used to describe these aspects can influence what is measured as outcomes and what is considered as evidence of improvement. Unhelpful or outmoded narratives could be a barrier to developing innovative interventions or in determining what works for whom. This UK study explor [...]

by Erina White  , Farzane Mohseni  and Meisam Amani

Received: 28 August 2021;  Published: 04 November 2021;  doi: 10.21926/aeer.2104028

The vitality of the Great Barrier Reef (GBR) is threatened by many human-made impacts. Monitoring this ecosystem makes it possible to study the general condition and the health of the GBR. However, due to the large extent of the GBR and limited accessibility in the ocean environment, mapping and monitoring this ecosystem has been always challenging task and connived. In this regard, Remote Sensing (RS) is an effective technique that provides valuable information for mapping and monitoring this ecosystem. In an atte [...]

by Joep P.M. Geraedts

Received: 15 December 2020;  Published: 28 January 2021;  doi: 10.21926/obm.neurobiol.2101085

Huntington’s disease (HD) is an autosomal dominant disease that immensely impacts the affected families. However, the transmission of the disease from carriers to their offspring could be prevented. Prenatal diagnosis (PND) and preimplantation genetic diagnosis (PGD) are the only two available reproductive options for the carriers at risk to have disease-free children. PND for HD could be done through two kinds of genetic testing: direct and indirect. The same approaches are available for preimplantation genetic te [...]

by Namita A. Goyal  and Tahseen Mozaffar

Received: 11 November 2020;  Published: 21 January 2021;  doi: 10.21926/obm.geriatr.2101154

Inclusion body myositis is one of the most common acquired myopathies seen in the aging population. The muscle weakness is of insidious onset, frequently starting in the legs, but over time gradually progresses to eventually involve all skeletal muscles of the limbs, face, swallowing and respiratory muscles, leading to significant morbidity and mortality. Complications resulting from dysphagia are the leading cause of poor quality of life and mortality, while highly prevalent, are still underappreciated and underre [...]

by Cheng Siew Goh  , Jia Ning Ting  and Arun Bajracharya

Received: 31 May 2022;  Published: 17 January 2023;  doi: 10.21926/aeer.2301010

Following the establishment of the United Nations’ Sustainable Development Goals, sustainability has been given increasing attention in the agenda of the built environment. Sustainability embraces three key elements, i.e., environment, economy and society. However, the social dimension receives the least attention and is largely overlooked compared to the environmental and economic sustainability. To bridge the gap, this paper will examine the various dimensions of social sustainability involved in the built enviro [...]

by Salvadora Martínez López  , Ascensión Banegas García  , Carmen Pérez Sirvent  , Maria José Martínez Sánchez  and Maria Angeles Esteban Abad

Received: 02 September 2023;  Published: 23 November 2023;  doi: 10.21926/aeer.2304051

This paper reviews the arsenic in the environment. Arsenic contamination is currently one of the leading environmental problems worldwide. The arsenic (As) cycle is the subject of this article because As is an element with a significant impact on living beings and because of its interrelation with other biogeochemical cycles. The biogeochemical cycle of As is closed, so this trace element returns to sediments where it can be changed in its chemical state by micro-organisms present in soils. In addition, some minera [...]

by Justin P. Rosenheck  , Mena M Botros  and David R Nunley

Received: 15 March 2021;  Published: 27 June 2021;  doi: 10.21926/obm.transplant.2102145

Lung transplantation is a therapeutic option for patients with advanced lung diseases. Lung transplant outcomes have improved over time with improvements in the management of these complex patients. Cytomegalovirus is a common opportunistic organism affecting all solid organ transplant recipients. Characteristics unique to lung transplantation can make this virus difficult to manage, with myriad complications including graft failure and death. Ongoing research into and understanding of cytomegalovirus has opened ex [...]

by Christopher Thomas  , Matthias Williams  and Oksana A. Shlobin

Received: 07 August 2023;  Published: 11 October 2023;  doi: 10.21926/obm.transplant.2304197

Lung transplantation is a last-resort treatment option for patients with end stage lung disease. The procedure is being performed more frequently and scientific advances continue to be made, but the median post-transplant survival is far shorter than other solid organ transplant recipients. Candidate selection is a resource intensive process that attempts to balance risks of the procedure with the benefits of much higher quality of life. Transplant centers must weigh disease specific considerations, medical comorbi [...]

by Dorit Shoval  , Nama Tal  and Orna Tzischinsky

Received: 21 July 2020;  Published: 08 March 2021;  doi: 10.21926/obm.neurobiol.2101088

The present study was aimed to examine the relationship of sleep–smartphone hygiene, i.e., the habits of smartphone usage in the sleep environment, with the sleep quality among students and whether this relationship could be explained through psychological factors. A total of 467 Israeli college students were investigated using five questionnaires, namely, Sleep–Smartphone Hygiene Questionnaire (SSHQ), Fear of Missing Out Scale (FoMOs), Trait Anxiety Inventory (STAI-T), Pittsburgh Sleep Quality Index (PSQI), and a [...]

by Abdirizak Jama Ali  , Shoaibur Rahman  and Asif Raihan

Received: 18 October 2022;  Published: 26 December 2022;  doi: 10.21926/aeer.2204056

The study was carried out in three different locations in Dinajpur district, Bangladesh，to observe soil carbon sequestration in agroforestry systems as a mitigation strategy for climate change. A total of 108 composite soil samples were collected at 0-30 cm in different study area sites. The total number of samples comprised three agroforestry systems (cropland agroforestry, homestead agroforestry, and orchard agroforestry)， where 36 samples were collected from each agroforestry system. Three adjacent soil samples [...]

by Tatsuya Nogami  , Makoto Arai  and Koh Iwasaki

Received: 12 January 2022;  Published: 28 February 2022;  doi: 10.21926/obm.geriatr.2201191

Several countries have entered the super-aging era. In Japan, the recently reported average life expectancy is approximately 90 years. Kampo medicine (a form of traditional Japanese medicine) is a part of the official medical service in Japan and is widely used for treating various illnesses of older people. However, although general physicians often prescribe Kampo preparations, most Japanese general physicians do not have an intimate understanding of the iatrology of Kampo. Kampo is based on traditional Chinese m [...]

by Hehe Zhang  , Ruihan Xu  and Shasha Zheng

Received: 03 March 2023;  Published: 28 September 2023;  doi: 10.21926/rpn.2303019

Uric acid (UA) metabolism, which includes uric acid production controlled by purine metabolism and uric acid excretion controlled by the gastrointestinal tract and kidneys, is the primary way to maintain the concentration of uric acid in the body. Abnormal functionalizing of the metabolism may cause hyperuricemia, gout, kidney injury, and other diseases. Over the last decade, numerous studies have been conducted on the effect of natural products, including active ingredients of medicinal plants, natural compounds, [...]

by Caymen M. Novak  , Eric N. Horst  , Shreya Raghavan  and Geeta Mehta

Received: 17 June 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903092

Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, and metastasis, and has been linked to the mechanotransduction of breast cancers. However, it is not currently known if shear stress mediated mechanotransduction is affected by COX-2. Therefore, in this report, we hypothesized that COX-2 m [...]

by Amy Anne D. Lassig  , Anna C. Wilson  , Walter N. Jungbauer  , Anne M. Joseph  , Bruce Lindgren  and Rick Odland

Received: 23 June 2023;  Published: 21 November 2023;  doi: 10.21926/rpn.2304021

Vitamin C is an oxidative stress mediator and essential cofactor in wound healing. The objective of this study was to investigate the clinical and biochemical effects of vitamin C supplementation on outcomes in patients undergoing mandibular fracture repair. We also aimed to evaluate the effects of sociodemographic, fracture, and treatment characteristics on post-operative clinical outcomes in these patients. The investigators conducted a double-blind, placebo-controlled, randomized clinical trial at Two Metropolit [...]

by Zsuzsanna M. Schmidt  and Gyula Poor

Received: 07 May 2022;  Published: 27 July 2022;  doi: 10.21926/obm.geriatr.2203202

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical "polymyalgic" musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck. PMR is a member of the so-called giant cell arteritis complex; however, in spite of the marked systemic inflammation in PMR, the local vasculitis process aborts. The pa [...]