by Abdirizak Jama Ali  , Shoaibur Rahman  and Asif Raihan

Received: 18 October 2022;  Published: 26 December 2022;  doi: 10.21926/aeer.2204056

The study was carried out in three different locations in Dinajpur district, Bangladesh，to observe soil carbon sequestration in agroforestry systems as a mitigation strategy for climate change. A total of 108 composite soil samples were collected at 0-30 cm in different study area sites. The total number of samples comprised three agroforestry systems (cropland agroforestry, homestead agroforestry, and orchard agroforestry)， where 36 samples were collected from each agroforestry system. Three adjacent soil samples [...]

by Justin P. Rosenheck  , Mena M Botros  and David R Nunley

Received: 15 March 2021;  Published: 27 June 2021;  doi: 10.21926/obm.transplant.2102145

Lung transplantation is a therapeutic option for patients with advanced lung diseases. Lung transplant outcomes have improved over time with improvements in the management of these complex patients. Cytomegalovirus is a common opportunistic organism affecting all solid organ transplant recipients. Characteristics unique to lung transplantation can make this virus difficult to manage, with myriad complications including graft failure and death. Ongoing research into and understanding of cytomegalovirus has opened ex [...]

by Jim Anbazu  and Nana Serwaa Antwi

Received: 14 February 2023;  Published: 17 October 2023;  doi: 10.21926/aeer.2304047

Urban heat island (UHI) effects are evident in many cities globally. Studies have revealed that UHI impacts air pollution and vice versa. However, it is observed that these two severe problems are addressed independently instead of interrelatedly. The study seeks to provide an in-depth understanding of the relationship between air pollution and heat and how they constantly shape urban areas for planning and future research purposes. A global shift from sustainable planning practices to building urban resilience exi [...]

by Mahintaj Dara  , Negin Shafieipour  , Mahsa Saffar  , Mehdi Dianatpour  , Seyed-Mohammad-Bagher Tabei  and Seyed-Alireza Dastgheib

Received: 18 November 2024;  Published: 01 April 2025;  doi: 10.21926/obm.genet.2502289

Since the initial discovery of the CRISPR system in bacteria as an adaptive immune system, a deeper understanding of CRISPR structure and function has made it possible to perform gene editing, gene therapy, and revolutionize the diagnostic field. One of the exciting applications of the CRISPR-Cas system is used as a tool for the rapid diagnosis of infectious diseases and their treatment and the prevention of infection spread among people. The CRISPR-based diagnostic system could be the next-generation standard beca [...]

by Zsuzsanna M. Schmidt  and Gyula Poor

Received: 07 May 2022;  Published: 27 July 2022;  doi: 10.21926/obm.geriatr.2203202

Polymyalgia rheumatica (PMR) is an age-related chronic inflammatory disease with rheumatic features at the fore. In addition to the high-grade systemic inflammation, it is characterized by typical "polymyalgic" musculoskeletal symptoms, including diffuse and severe pain and prolonged morning stiffness of the shoulder girdle, pelvic girdle, and neck. PMR is a member of the so-called giant cell arteritis complex; however, in spite of the marked systemic inflammation in PMR, the local vasculitis process aborts. The pa [...]

by Hehe Zhang  , Ruihan Xu  and Shasha Zheng

Received: 03 March 2023;  Published: 28 September 2023;  doi: 10.21926/rpn.2303019

Uric acid (UA) metabolism, which includes uric acid production controlled by purine metabolism and uric acid excretion controlled by the gastrointestinal tract and kidneys, is the primary way to maintain the concentration of uric acid in the body. Abnormal functionalizing of the metabolism may cause hyperuricemia, gout, kidney injury, and other diseases. Over the last decade, numerous studies have been conducted on the effect of natural products, including active ingredients of medicinal plants, natural compounds, [...]

by Tatsuya Nogami  , Makoto Arai  and Koh Iwasaki

Received: 12 January 2022;  Published: 28 February 2022;  doi: 10.21926/obm.geriatr.2201191

Several countries have entered the super-aging era. In Japan, the recently reported average life expectancy is approximately 90 years. Kampo medicine (a form of traditional Japanese medicine) is a part of the official medical service in Japan and is widely used for treating various illnesses of older people. However, although general physicians often prescribe Kampo preparations, most Japanese general physicians do not have an intimate understanding of the iatrology of Kampo. Kampo is based on traditional Chinese m [...]

by Carlos A. Echeverry-Gonzalez  and Vladimir V. Kouznetsov

Received: 01 December 2020;  Published: 28 April 2021;  doi: 10.21926/rpm.2102015

The design of nanomaterials for application in diverse fields ranging from photovoltaic to fluorescence sensing is a research area of increasing interest. Recently, Quantum Dots (QDs), which are classified as semiconductor quantum dots (SQDs) and Carbon dots (CDs), have become a hot topic of investigation, owing to their extraordinary tunable fluorescence emission properties that render them excellent candidates for sensing metal ions. The detection of metal ions in aqueous solutions with high sensitivity is very i [...]

by John Old  and Cornelis Harteveld

Received: 03 July 2017;  Published: 14 August 2017;  doi: 10.21926/obm.genet.1703005

Carrier screening for the haemoglobinopathies has undergone many technological improvements in haematological and molecular diagnostic techniques since the first prenatal diagnoses by DNA analysis in the 1970s by Southern blot analysis enabled the implementation of effective successful prevention programmes for beta thalassaemia involving public education, carrier screening, genetic counselling and prenatal diagnosis in Mediterranean countries. The application of a wide variety of PCR-based molecular diagnostic tec [...]

by Steve Liebich

Received: 16 March 2020;  Published: 02 July 2020;  doi: 10.21926/obm.genet.2003113

Multicellularity has gained the advantage over the unicellular world by expanding the number of increasingly more complex tissues that achieve advanced and specific functions. This same event gave rise to the most evolved group of organisms, namely mammals. Even though the complexity of multicellular organisms does not necessarily provide them with excellent adaptation modes performed by unicellular and prokaryotic organisms, this complexity per se stands as one of the greatest phenomena in biology. However, there [...]

by Prabhumallikarjun Patil  and Amanda RB Weber

Received: 18 January 2022;  Published: 22 July 2022;  doi: 10.21926/obm.neurobiol.2203129

Cerebral palsy is defined as “A group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The motor disorders of cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, and behavior, by epilepsy, and by secondary musculoskeletal problems [1].” Between 30-40% of people with cerebral palsy also have epilepsy [2,3,4]. Som [...]

by Darren E. Stewart  , Amber R. Wilk  and David K. Klassen

Received: 14 December 2018;  Published: 22 January 2019;  doi: 10.21926/obm.transplant.1901041

Background: This study examines very recent trends in deceased donor kidney transplantation to assess the performance of the kidney allocation system (KAS), implemented December 4, 2014, and whether bolus effects associated with KAS have stabilized nearly four years after implementation. Methods: The overall number of deceased donor kidney transplants, as well as the proportion of transplants by recipient and transplant characteristics, were calculated monthly from December 2013 through September 2018 and examined [...]

by Caymen M. Novak  , Eric N. Horst  , Shreya Raghavan  and Geeta Mehta

Received: 17 June 2019;  Published: 06 September 2019;  doi: 10.21926/obm.genet.1903092

Background: Invasive breast cancer affects 1 in 8 women in the United States and causes one of the highest cancer mortality rates for women. Cyclooxygenase-2 (COX-2), a central enzyme in prostaglandin biosynthesis, is implicated in breast cancer initiation, progression, invasion, and metastasis, and has been linked to the mechanotransduction of breast cancers. However, it is not currently known if shear stress mediated mechanotransduction is affected by COX-2. Therefore, in this report, we hypothesized that COX-2 m [...]

by Sonal Mishra  , Neha Kumari  , Donat-P. Häder  and Rajeshwar P. Sinha

Received: 03 January 2022;  Published: 16 March 2022;  doi: 10.21926/aeer.2201011

Cyanobacteria are the most ancient phytoplankton that first appeared at least 2.5 billion years ago and have a prolonged evolutionary history. They can form impenetrable and toxic blooms in aquatic ecosystems such as freshwater and marine environments. Cyanobacterial blooms produce cyanotoxins that endanger ecosystem functioning and deteriorate water quality used for recreation, drinking, and in fisheries, thus, adversely affecting human health and the economy. Some bloom-producing genera are Aphanizomenon, Plankto [...]

by Amber Bonnington  , Meisam Amani  and Hamid Ebrahimy

Received: 13 August 2021;  Published: 14 October 2021;  doi: 10.21926/aeer.2104024

Since oil exploration began, oil spills have become a serious problem. When drilling for oil, there is always a risk of an oil spill. With the new development of technology over the years, oil spill detection has become much easier making the clean-up of a spill to happen much faster reducing the risk of a large spread. In this study, remote sensing techniques were used to detect the Deep-water Horizon oil spill through a change detection method. The change detection method allows the viewer to determine the differ [...]

by Gulzhaina K. Kassymova  , Mariam R. Arpentieva  , Bakhyt D. Zhigitbekova  , Hans Schachl  , Aigerim N. Kosherbayeva  , Kundyz Zh. Aganina  , Farid R. Vafazov  , Petr V. Menshikov  , Marina G. Golubchikova  and Andrey I. Korobchenko

Received: 07 March 2023;  Published: 07 November 2023;  doi: 10.21926/obm.neurobiol.2304193

Stressful events in students' and teachers' personal, academic, and professional lives are widespread. The paper discusses many effective methods and techniques for correcting and preventing stress that are simple to learn and practice. They give good results in working with children, adolescents, and youths in training and education. Some practices are more complex and require more attention and effort to understand and master them, but they also have broader capabilities in various situations. Therefore, training [...]

by Kelly Swing  , Jaime Chaves  , Stella de la Torre  , Luis Sempértegui  , Alex Hearn  , Andrea Encalada  , Esteban Suárez  and Gonzalo Rivas

Received: 30 March 2022;  Published: 22 September 2022;  doi: 10.21926/aeer.2203035

The rights of nature have been widely discussed at a philosophical level for a long time, but examples of its practical application are quite rare. Ecuador is the first country to incorporate this concept into its constitutional foundation and put the theory into practice. However, implementing entirely justifiable rights of nature is hindered by factors, such as economic considerations, legal interpretations, cultural norms, political will, and disproportionate perspectives of “the greater good”. After getting opp [...]

by Michael F Knoll  , Carmela A Knoll  , Rita Bottino  , Suzanne Bertera  and Massimo Trucco

Received: 12 January 2021;  Published: 25 March 2021;  doi: 10.21926/obm.transplant.2101140

Clinical islet transplantation was first realized over four decades ago at the University of Minnesota. Autologous islet transplantation is now widely recognized as a treatment to prevent diabetes in patients after pancreas excision and is offered at major transplant centers throughout the United States and the world. Type 1 diabetes represents a much larger demographic in which islet transplantation may benefit patients. Allogeneic islet transplantation can now offer similar outcomes to pancreas transplantation in [...]

by Christin Deal  , Kara Coffey  and Hey Chong

Received: 02 June 2023;  Published: 04 August 2023;  doi: 10.21926/obm.genet.2303190

Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) has been successfully implemented in all 50 United States and Puerto Rico from 2008-2018. This life-saving screening tool has drastically improved overall survival of babies diagnosed with SCID from 74% to 96%. TREC is a stable, circular DNA molecule that is produced during the process of T-cell receptor (TCR) rearrangement and is the target of the quantitative PCR screen on Guthrie cards. Low TRECs are a marker of low naive T cell numbers. This ne [...]

by Uttayan Chakrabarti  , Manish Chaturvedy  , Nitin Kumar Bajpai  , Jitendra Goswami  , Rajesh Kumar Garsa  and Rajesh Jhorawat

Received: 10 April 2023;  Published: 14 July 2023;  doi: 10.21926/obm.transplant.2303192

BK virus (BKV) is a common opportunistic pathogen in kidney transplant recipients and one of the most challenging causes of allograft dysfunction and loss. Although over-immunosuppression remains the primary risk factor for BKV infection after transplantation, male gender, older recipient age, prior rejection episodes, degree of human leukocyte antigen mismatching, prolonged cold ischemia time, BK virus serostatus and ureteral stent placement have all been implicated as risk factors. Routine screening post-renal tr [...]

by Cristina Lull  , Antonio Lidón  and María Desamparados Soriano

Received: 25 March 2022;  Published: 10 June 2022;  doi: 10.21926/aeer.2202024

Soil pollution is a major challenge for ensuring a healthy environment and for human health. One of the critical points in soil pollution policy is the education and public awareness of the problem caused by soil pollution. Education influences decision-making on soil and water care. It is crucial to spread knowledge to undergraduate and graduate students about the determinantal effects of soil pollution on ecosystems and humans, considering today’s students are tomorrow’s guardians of soil and human health. A cour [...]

by Lindsey Cundra  , Michael Saadeh  , Manasa Vallabhaneni  , Kevin Houston  , Steve D’Souza  and David A Johnson

Received: 28 April 2022;  Published: 09 August 2022;  doi: 10.21926/rpn.2203019

Inflammatory bowel disease (IBD), which includes ulcerative colitis, and Crohn’s disease, is a chronic relapsing-remitting inflammatory state of the gastrointestinal (GI) system. The cause of IBD is multifactorial, encompassing factors of genetics, environment, and the host immune system, initiating a complex interplay of maladaptive host immune responses and subsequent chronic inflammation. Aberrant host immune responses are at least in part due to changes in the commensal microbiome, which can in turn affect the [...]

by Arnold De Loof  and Liliane Schoofs

Received: 03 October 2019;  Published: 29 November 2019;  doi: 10.21926/obm.neurobiol.1904046

There is a growing awareness that the proteins—amyloid-beta (Aβ) and tau—do not cause Alzheimer’s disease (AD) but are produced as a result of it. Similarly, doubt reigns over the degree of causality of high plasma cholesterol and prenylation in AD. This review proposes a fresh and important perspective, in addition to the current line of thinking. It emerges from comparative analysis, in evolutionary retrospect, of the characteristics of the mevalonate biosynthetic pathways in insects versus [...]

by Leonard A. Jason

Received: 15 October 2024;  Published: 05 February 2025;  doi: 10.21926/obm.neurobiol.2501267

Following mental or physical exertion, patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) experience Post-Exertional Malaise (PEM). Although self-report questions represent less expensive and invasive procedures to assess PEM, variability in the wording of the symptom can cause reliability and validity problems. If different PEM measures are used in studies, this could create difficulties in replicating findings, identifying biomarkers, and determining effective treatments for patients. The o [...]

by Chiara Castellani  , Emanuele Molteni  , Serena Colafrancesco  , Fabrizio Conti  , Roberta Priori  and Rossana Scrivo

Received: 13 August 2020;  Published: 18 November 2020;  doi: 10.21926/obm.geriatr.2004139

Musculoskeletal conditions represent one-third to more than one-half of all non-communicable disease multimorbidities in the elderly, worsening their disability because of pain and limited physical function, often concurring with their mental decline. Musculoskeletal conditions significantly contribute to frailty and global disability, second only to mental health conditions. Furthermore, premature mortality, generally due to an increased risk of developing cardiovascular disease, has been documented in several rhe [...]