Register or Submit a manuscript.
Table of Content

Open Access Opinion

Belatacept Dosing in Lung Transplantation: Is There a Method to the Madness?

Received: 09 July 2021;  Published: 30 August 2021;  doi: 10.21926/obm.transplant.2103152

Abstract

Data supporting the use of belatacept in non-abdominal organs are limited to case series and small cohorts involving patients requiring conversion due to CNI intolerance or contraindication. Review articles summarizing the efficacy of belatacept salvage therapy in lung transplantation have previously been published, however, dosing regimens are highly variable and uniform guidance is lacking. In this article, indications and considerations for belatacept use in lung transplant recipients are reviewed with a specifi [...]

1800 13562

Open Access Case Report

Pandemics 2020 –COVID 19 Silent Hypoxia and Polysubstance Use: A Unique Case Report

Received: 24 December 2020;  Published: 30 August 2021;  doi: 10.21926/obm.icm.2103025

Abstract

The coronavirus (COVID-19) pandemic continues to bring challenges in identification and management of which the “happy hypoxic” or silent hypoxia presentation has been found to present its own unique challenge. A 67-year-old African American COVID-19 positive female presents to the emergency department (ED) with a chief complaint of decreased oral intake and responsiveness, oriented and stable, with oxygen saturations found to drop as low as 47%. The patient was successfully managed with supplemental oxygen and det [...]

1329 7743

Open Access Review

Effects of the COVID-19 Pandemic on the Urban Water Cycle

Received: 27 May 2021;  Published: 30 August 2021;  doi: 10.21926/aeer.2103021

Abstract

The coronavirus disease 2019 (COVID-19) is a global crisis spreading to all countries. This study explains and documents the first-order effects of the new coronavirus on the urban water cycle. Urban water systems play an important role in public health because people rely so heavily on water services. Findings address short- and long-term changes in climate variables; availability and accessibility of clean water to prevent and control the spread of coronavirus in water-scarce cities; shifts in habits, behavior, a [...]

1905 19943

Open Access Original Research

About Cryptic Acrocentric Pericentromeric Abnormalities in Infertile

Received: 16 April 2021;  Published: 25 August 2021;  doi: 10.21926/obm.genet.2103135

Abstract

Cryptic balanced chromosomal aberrations can be an underlying cause of infertility. In 2003 Cockwell and coworkers highlighted the relevance of euchromatic pericentric regions of acrocentric chromosomes that may be a yet ignored genomic region hosting cryptic rearrangements. Here we offer the first follow-up study to further explore this idea. Two specific molecular cytogenetic probe sets were established to elucidate such cryptic rearrangements together with chromosomal heteromorphisms of acrocentric centromeres. [...]

1580 8884

Open Access Original Research

Reconstruction of Anthropogenic Land-Cover Change for Middle America, 1500 CE

Received: 07 March 2021;  Published: 24 August 2021;  doi: 10.21926/aeer.2103020

Abstract

This project demonstrates how to use existing syntheses of many decades of historical social science research to produce empirically derived land-use maps in a GIS for large regions for a specific target year at a resolution appropriate to the calibration of existing anthropogenic land-cover change (ALCC) models. Disagreement among the outputs of various ALCC models results from differing estimates of population and assumptions about how much food a given population requires and the productivity per unit area of va [...]

1519 11376

Open Access Original Research

Single-Case Neuropsychological Assessment of a Patient with a Posterior Parietal Lesion Using Behavioral Testing and Resting-State fMRI

Received: 29 January 2021;  Published: 24 August 2021;  doi: 10.21926/obm.neurobiol.2103105

Abstract

This study integrated functional connectivity measures using resting-state fMRI and behavioral data from a single-case observation of patient (PER) one year after right-hemispheric hemorrhage in the intraparietal sulcus and superior parietal lobule (IPS/SPL). PER showed no sign of clinical neglect. Her behavioral performance in the visuo-manual pointing task and in the letter discrimination task under conditions of endogenous and exogenous attentional cueing was compared between the left (affected) and right (unaff [...]

1595 10234

Open Access Original Research

Homeopathy and Photobiomodulation for Healing Diabetic Wounds in vitro

Received: 12 April 2021;  Published: 19 August 2021;  doi: 10.21926/obm.icm.2103024

Abstract

Photobiomodulation (PBM), as well as plant extracts of Calendula officinalis (Calen), Hypericum perforatum (Hyper), and Echinacea purpurea (Echi-p), have been used to accelerate wound healing. However, the use of homeopathic preparations of these medicinal plants, in combination with PBM, is unknown. The objective of this study was to investigate the combined wound healing potential of these therapies in vitro. Various cell models were created in vitro in commercially available human skin fibroblasts (WS1). PBM was [...]

1602 16682

Open Access Research Article

Surgical Treatment of Zenker’s Diverticulum in Older Patients

Received: 26 October 2020;  Published: 18 August 2021;  doi: 10.21926/obm.geriatr.2103179

Abstract

Zenker’s diverticulum is a cause of benign dysphagia. The main symptoms include dysphagia and regurgitation and require diagnostics to exclude neoplastic disease. Surgical treatment is recommended for symptomatic patients. The methods of treatment include endoscopic and open transcervical techniques. Thirty-eight patients treated using the open technique between 2000 and 2020 were analyzed. Patients were qualified for the procedure after a complete diagnosis that excluded the neoplastic process. All patients were a [...]

1579 13534

Open Access Research Article

Utilization of Upgraded Recycled Concrete Aggregates and Recycled Concrete Fines in Cement Mortars

Received: 11 February 2021;  Published: 17 August 2021;  doi: 10.21926/rpm.2103035

Abstract

Waste concrete is the most predominant constituent material among construction and demolition waste. Current waste concrete recycling is limited to the use of recycled concrete aggregates as a road-base material and less as aggregates in new concrete mixes. Further, the production of recycled concrete aggregates results in the generation of a high amount of fines, consisting mainly of cement paste particles. Hence, this study aims to produce the cement mortars using the upgraded recycled concrete aggregates (sand g [...]

2029 15507

Open Access Research Article

GIS-based MCDM Approach for Wind Farm Site Selection - A Case Study

Received: 08 May 2021;  Published: 17 August 2021;  doi: 10.21926/jept.2103039

Abstract

The objective of this study is the development and implementation of a geographic information system (GIS)-based methodology to determine suitable sites for wind farms by using multicriteria decision making (MCDM) techniques. Many eligibility criteria are considered in this approach, such as GIS analysis is performed in combination with MCDM techniques, both for the criteria weighting process (using the analytical hierarchical process) and for the standardization/classification of the criteria values into a common [...]

2223 20441

Open Access Review

Defining Clinically Pathogenic HLA-Specific Antibodies - Granular Details in Characteristics in Pre and Early Time Following HLA-Antibody Incompatible Kidney Transplantation

Received: 11 May 2021;  Published: 17 August 2021;  doi: 10.21926/obm.transplant.2103151

Abstract

Antibodies against donor HLA determine access to solid organ transplantation and in many cases the outcome of transplantation, but graft failure is not an inevitable consequence of their presence. Much research has been performed with two main aims – which antibodies represent the highest risk factor prior to transplantation, and second to understand how donor specific HLA antibodies behave after transplantation, with a long-term aim of being able to manipulate their production. HLA antibody incompatible kidney tra [...]

1698 11068

Open Access Technical Note

Encoding, Regression, and Classification of Transcription Factors’ Specificity and Methylation Effects

Received: 01 February 2021;  Published: 16 August 2021;  doi: 10.21926/obm.genet.2103134

Abstract

The methylation effects on protein-DNA interactions, which can be perceived as a special kind of specificity of transcription factors, have been successfully quantified in the last years by various methods. In this work, I give a summary about the sequence encoding scheme, the underlying additive model about specificity and methylation sensitivity, and the regression strategy to analyze Methyl-Spec-seq data. Then I explain why given the current experimental setup, it is more appropriate to model the methylation eff [...]

1763 8521

Open Access Original Research

New Electrocatalysts Prepared by Co-Sputter Deposition for the Direct Oxidation of Methanol

Received: 25 May 2021;  Published: 13 August 2021;  doi: 10.21926/jept.2103038

Abstract

Direct methanol oxidation catalysts Pt1-x-Tax (0

1807 11506

Open Access Review

Gastro-Esophageal Reflux in the Newborn: Pathologic Event or Does Spit Happen?

Received: 19 April 2021;  Published: 13 August 2021;  doi: 10.21926/obm.hg.2103060

Abstract

Infants admitted to Neonatal Intensive Care Units (NICUs) are among the most vulnerable patients in medicine and are at risk for a variety of morbidities, many of which require pharmacologic therapy. Gastroesophageal Reflux Disease (GERD) is a common diagnosis in the NICU patient population and may or may not represent a truly pathologic process. Regardless, pharmacologic therapy is provided to many infants, who are already exposed to an inordinate number of pharmacologic agents, of which most are off label and hav [...]

1202 8542

Open Access Original Research

Bisphenol A Release from Orthodontic Clear Aligners: An In-Vitro Study

Received: 31 March 2021;  Published: 12 August 2021;  doi: 10.21926/rpm.2103034

Abstract

Bisphenol A (BPA) is a widely used synthetic compound that has been identified as an endocrine disruptor. It has been linked to adverse health effects such as developmental defects, infertility in both men and women, cardiovascular disease, and obesity. There has been increased interest in BPA’s effects on the developing fetus and data has revealed that doses below the presumed safe dose can produce harmful effects. Orthodontic clear aligner therapy is a popular treatment modality that involves the patient we [...]

2855 39920

Open Access Original Research

A Highly-efficiency Position Sensorless Electric Vehicle Synchronous Reluctance Motor Drive

Received: 02 May 2021;  Published: 11 August 2021;  doi: 10.21926/jept.2103037

Abstract

The development of high-efficiency motor drives for various applications is important in the industry 4.0 era, especially for their extensive application to electric vehicles (EVs). In this study, a position sensorless EV synchronous reluctance motor (SynRM) drive has been developed, which exhibits good driving performance and efficiency over a wide speed and load range. To solve the key problems popularly encountered in the existing approaches, the high-frequency injection (HFI) scheme based on q-axis injection ha [...]

1742 10610

Open Access Review

The Science of the “Simile”

Received: 20 April 2021;  Published: 11 August 2021;  doi: 10.21926/obm.icm.2103023

Abstract

Homeopathy is often attacked with claims of not being evidence-based or for the implausible nature of its major principles of dilution/potentization and/or the similars (“similia similibus curentur”). However, these statements have already been falsified on the experimental ground, besides being incorrect on an epistemological level. Here we provide an updated appraisal of the scientific approach to the principle of Similars and homeopathy, focusing on laboratory models. After a brief historical introdu [...]

2105 14448

Open Access Original Research

Effect of Recycled Rubber Particles on the Deicing Salt-Scaling Durability of Concrete

Received: 27 March 2021;  Published: 09 August 2021;  doi: 10.21926/rpm.2103033

Abstract

The present study investigated the effect of reused rubber particles (RRP) on the deicer salt durability of ordinary concrete. Four mixtures were designed, a control concrete (CC) and three other rubber concretes obtained by partial substitution of natural dune sand aggregate with reused rubber particles with 0%, 3%, 6%, and 9% w/w. All studied concretes were subjected to the combined effect of freeze/thaw (56 and 120) cycles with the deicer salt solution of 3% NaCl. The results indicated that RRP improved the deic [...]

1520 8937

Open Access Research Article

Maintenance Optimization of Wind Turbines Using Weather-Dependent Equivalent Age Model

Received: 26 April 2021;  Published: 04 August 2021;  doi: 10.21926/jept.2103036

Abstract

Aging models are important input into wind farm maintenance and financial viability models. Aging of wind turbines depends on many factors, including both ambient and usage conditions. This paper presents a virtual age based maintenance model for wind turbines considering the effect of wind speed and ambient air temperature on turbine aging. Two maintenance thresholds (i.e., corrective threshold and preventive threshold) and three repair actions (i.e., unscheduled corrective, scheduled corrective and preventive act [...]

1766 12706

Open Access Original Research

A Comparative Study of Structural, Optical and Electrical Properties of Fe-ZnO Nanoparticles Synthesized by Precipitation and Microwave Method for Photovoltaic Applications

Received: 12 May 2021;  Published: 04 August 2021;  doi: 10.21926/jept.2103035

Abstract

Iron doped ZnO (Fe-ZnO) nanoparticles were synthesized using two techniques that are economical as well as scalable to yield tunable properties of nanoparticles for facilitating down conversion in an absorbing layer of a solar cell. To evaluate the suitability of Fe-ZnO nanoparticles prepared by two deposition methods, we present a comparison of optical, electrical, and structural properties of Fe-ZnO using several experimental techniques. Structural properties were analyzed using transmission electron microscopy a [...]

1831 10892

Open Access Review

Epigenetics and Medicine

Received: 23 March 2021;  Published: 30 July 2021;  doi: 10.21926/obm.genet.2103133

Abstract

“Epigenetics is the study of how your behaviors and environment can cause changes that affect the way your genes work. Unlike genetic changes, epigenetic changes are reversible and do not change your DNA sequence, but they can change how your body reads a DNA sequence” (https://www.cdc.gov/genomics/disease/epigenetics.htm). Epigenetic interactions, along with the genetic expression in innate cells, change the structure and function of chromatin, and thus, turn the genes on and off. Epigenetic changes influence dise [...]

1893 10382

Open Access Original Research

Analysis of Surface Water Areal changes using Remote Sensing Data

Received: 23 October 2020;  Published: 29 July 2021;  doi: 10.21926/aeer.2103019

Abstract

Inland water bodies are crucial for supporting human life in various parts of the world. Therefore, it is essential to accurately monitor its spatiotemporal variations for better water management. The main objective of this study is to investigate the application of remote sensing data for quantifying the surface area changes and the impact of climatological variabilities over Lakes Mead and Chapala. Historical time series of monthly surface area dynamics were developed using Landsat 1-8 scenes and the climate vari [...]

1772 12278

Open Access Review

Diagnosis and Therapy of Atrial Fibrillation in Geriatric Patients

Received: 16 January 2021;  Published: 28 July 2021;  doi: 10.21926/obm.geriatr.2103178

Abstract

Atrial fibrillation is very common in most old patients who need an adapted therapy due to their comorbidities. Before initiating an antiarrhythmic therapy, possible adverse effects, especially iatrogenic proarrhythmia, and extracardiac side-effects, must be considered. In geriatric patients with atrial fibrillation, heart rate control is the most frequent therapy. Oral anticoagulation plays a vital role in the therapy, but anticoagulation in old patients, who had a bleeding or stroke event, is challenging. Availab [...]

1701 15607

Open Access Research Article

Effect of 12 Months of Oral Exercise on the Oral Function of Older Japanese Adults requiring Care

Received: 23 October 2020;  Published: 28 July 2021;  doi: 10.21926/obm.geriatr.2103177

Abstract

Objective: The present study aimed to elucidate the relationship between oral exercise and oral function among older adults requiring care in the nursing facilities of Japan. Methodology: The subjects were adults aged 65 years or above, requiring care and admitted to the nursing facilities for older adults in Japan. The subjects performed the assigned oral exercises, which included the exercises focused on the neck, shoulder, upper limbs, tongue, lips, cheek movement, vocalization, and deep breathing, in groups und [...]

1676 10732

Open Access Original Research

Experimental and Statistical Evaluation of the Interaction Effect of Recycled Aggregate and Water/Cement Ratio on Concrete Compressive Strength

Received: 07 March 2021;  Published: 28 July 2021;  doi: 10.21926/rpm.2103032

Abstract

The production of concrete using recycled aggregates, obtained from the processing of construction and demolition waste, is extensively practiced worldwide. However, the effect of simultaneous adding fine recycled aggregate and the recycled coarse aggregate on the mechanical properties of concrete is still unfamiliar. This work aims to evaluate the influence of the water/cement ratio (WC Ratio), the fine recycled aggregate content (%FRA), the coarse recycled aggregate content (%CRA), as well as the interaction betw [...]

1733 10931

Newsletter  

TOP