by Jenny Berrío  , Weiwen Wang  and Bart A. Ellenbroek

Received: 22 February 2019;  Published: 14 March 2017;  doi: 10.21926/obm.neurobiol.1701001

Antipsychotics have been a pillar in the treatment of schizophrenia since their introduction more than 60 years ago. Their variety in structures and receptor binding properties confers on them a complex clinical profile of effectiveness and risk of adverse side-effects. Although antipsychotics are best known for their therapeutic effects in schizophrenia, these are limited to the positive symptoms, with much less influence on negative symptoms or cognitive deficits. Moreover, although the newer (so-called second-ge [...]

by Toshiaki Suzuki  , Makiko Tani  , Kaito Takamori  and Maki Yamada

Received: 21 January 2017;  Published: 20 February 2017;  doi: 10.21926/obm.icm.1701001

(1) Background: Acupoint stimulation physical therapy (ASPT) is a novel method of physical therapy that combines physical and acupuncture methods. This study aimed to examine the effect of ASPT in three hemiplegic patients with cerebrovascular disease using F-wave as a measure of the excitability of spinal neural function. (2) Methods: Subjects included three hemiplegic patients with cerebrovascular disease who presented with three types of neurological findings. All patients had moderate hypertonic muscles on the [...]

by Ron Hochstenbach  , Martin Poot  and Thomas Liehr

Received: 15 November 2016;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701002

Small supernumerary marker chromosomes (sSMCs) are centric chromosome fragments additionally present in an otherwise normal human chromosome set that cannot be characterized by classical cytogenetic techniques alone. The majority of sSMCs are not yet related to a defined clinical phenotype. We compiled from the literature all 78 cases with multiple sSMCs per cell in which the chromosomal origin of the sSMCs has been identified. The number of sSMCs varies from 2 to 7; 64% have 2 sSMCs, 14% have 3 sSMCs, and the freq [...]

by Joep Geraedts

Received: 16 January 2017;  Published: 10 February 2017;  doi: 10.21926/obm.genet.1701001

by Tatsuo Kanda  and Osamu Yokosuka

Received: 22 January 2017;  Published: 03 February 2017;  doi: 10.21926/obm.hg.1701002

by Hidehiro Kamezaki  , Tatsuo Kanda  , Osamu Yokosuka  , Yasunori Kasahara  and Takayuki Sakurai

Received: 16 November 2016;  Published: 21 January 2017;  doi: 10.21926/obm.hg.1701001

(1) Background: Preventative treatment for Pneumocystis jirovecii pneumonia (PCP) has been recommended for patients receiving ≥20 mg/day prednisolone. We describe a patient who developed PCP while receiving a dose of 15 mg/day prednisolone, and consider criteria for the initiation of preventative therapy for PCP in patients with autoimmune hepatitis (AIH) treated with prednisolone. (2) Case Report: A 71-year-old woman initially possessed dark-colored urine, white stool, and decreased appetite, which indicated hepat [...]

by Michael Fossel

Received: 11 December 2016;  Published: 06 January 2017;  doi: 10.21926/obm.geriatr.1701001

Geriatrics, and much of clinical medicine, is on the verge of a profound transformational shift. Until now, there has been a sharp conceptual divide between diseases which can be readily and effectively treated, and diseases which we have thought to be beyond clinical intervention. In the first disease category, are many of the most common infections that respond to antibiotics and immunizations. We have made dramatic changes in the demographics and the mortality of many such treatable diseases. At the other extrem [...]

by Bo Pang  , Qi Zhang  , Guang-Yu Cheng  , Wei-Ping Cheng  , Daniela Litscher  , Lu Wang  , Zemin Sheng  , Ingrid Gaischek  , Zhong-Ren Sun  and Gerhard Litscher

Received: 08 June 2016;  Published: 23 August 2016;  doi: 10.21926/obm.icm.1601003

(1) Background: Within this study, we assessed the effects of acupuncture on heart rate variability (HRV) in Chinese post-stroke patients. (2) Methods: In 30 Chinese post-stroke patients (14 f, 16 m; mean age ± SD 64.3 ± 3.8 years; range 40 - 80 years) electrocardiographic signals before, during and after acupuncture at the left Weizhong acupoint (BL40) were recorded in Harbin and analyzed in Graz using teleacupuncture via internet. HRV data were analyzed in the time and frequency domain and a protoco [...]

by Daniela Litscher  and Gerhard Litscher

Received: 24 May 2016;  Published: 17 August 2016;  doi: 10.21926/obm.icm.1601002

The present report deals with some current important aspects of traditional Chinese medicine (TCM) education and practice in Europe and China. The data and facts are based on a lecture of one of the authors (G.L.) prepared for a conference in Wuhan about acupuncture education in Europe, and lectures of two high-ranking representatives of renowned Chinese institutions (State Administration of TCM and Heilongjiang University of Chinese Medicine, Harbin). In addition to current figures regarding TCM in general, the ad [...]

by Gerhard Litscher

Received: 27 May 2016;  Published: 15 August 2016;  doi: 10.21926/obm.icm.1601001

Integrative and Complementary Medicine (ICM-OBM) is an international peer-reviewed, open-access journal which covers all evidence-based scientific studies on integrative and complementary approaches to improving health and quality of life. Integrative and complementary medicine comprises science-oriented “university” or academic medicine, but also experience-based medicine with all its complementary methods. It is not a special field in itself, but a signal for an all-encompassing medicine, open-minded about the p [...]