OBM Geriatrics is an Open Access journal published quarterly online by LIDSEN Publishing Inc. The journal takes the premise that innovative approaches – including gene therapy, cell therapy, and epigenetic modulation – will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. We will give strong preference to papers that emphasize an alteration (or a potential alteration) in the fundamental disease course of Alzheimer’s disease, vascular aging diseases, osteoarthritis, osteoporosis, skin aging, immune senescence, and other age-related diseases.

Geriatric medicine is now entering a unique point in history, where the focus will no longer be on palliative, ameliorative, or social aspects of care for age-related disease, but will be capable of stopping, preventing, and reversing major disease constellations that have heretofore been entirely resistant to interventions based on “small molecular” pharmacological approaches. With the changing emphasis from genetic to epigenetic understandings of pathology (including telomere biology), with the use of gene delivery systems (including viral delivery systems), and with the use of cell-based therapies (including stem cell therapies), a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Precedence will be given to papers describing fundamental interventions, including interventions that affect cell senescence, patterns of gene expression, telomere biology, stem cell biology, and other innovative, 21st century interventions, especially if the focus is on clinical applications, ongoing clinical trials, or animal trials preparatory to phase 1 human clinical trials.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes a variety of article types (Original Research, Review, Communication, Opinion, Comment, Conference Report, Technical Note, Book Review, etc.). There is no restriction on the length of the papers and we encourage scientists to publish their results in as much detail as possible.

Publication Speed (median values for papers published in 2023): Submission to First Decision: 5.7 weeks; Submission to Acceptance: 17.9 weeks; Acceptance to Publication: 7 days (1-2 days of FREE language polishing included)

Current Issue: 2024  Archive: 2023 2022 2021 2020 2019 2018 2017

Special Issue

Alzheimer's Disease: Current Knowledge and Future Perspectives

Submission Deadline: June 30, 2025 (Open) Submit Now

Guest Editor

R. M. Damian Holsinger, PhD

1. Neuroscience, School Wof Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
2. Laboratory of Molecular Neuroscience and Dementia, The Brain and Mind Centre, The University of Sydney, Camperdown, Australia

Website | E-Mail

Research Interests: Understanding of mechanisms by which complex neurological disorders (with a special interest in Alzheimer's disease) arise and methods of treating these diseases

About This Topic:

Alzheimer’s disease (AD), the leading cause of dementia, is a progressive neurodegenerative disease of the brain that is characterized by memory impairment and cognitive dysfunction. Pathological hallmarks of AD include the extracellular deposition of amyloid beta (Aβ) plaques and the intracellular accumulation of neurofibrillary tangles that is accompanied by neuroinflammation. Age is the most common risk factor for the disease. Recently however, genome wide association studies (GWAS) have identified several AD risk-associated genes. This information is changing the landscape of disease recognition and diagnosis. The literature is repleat with new information and data that is establishing a paradigm shift in the manner in which we investigate and treat individuals with Alzheimer’s. 

In this Special Issue, we aim to draw together research from experts in the field that highlight current knowledge of disease entities and therapeutic strategies and interventions and identify future directions that will lead to discoveries and therapies for Alzheimer’s disease.


Aging; Amyloid peptides; Astrocytes; Biomarkers; Cognition; GWAS; Imaging; Memory deficits; Microglia; Neurodegeneration; Neuroinflammation; Oxidative Stress; Plaques; Tangles; Tau protein

Manuscript Submission Information

Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (geriatrics@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.

Welcome your submission!


Open Access Perspective

Leveraging Existing Abilities in Dementia (LEAD™): Changing the Way Rehabilitation Professionals Care for Persons Living with Dementia

Received: 08 December 2023;  Published: 03 April 2024;  doi: 10.21926/obm.geriatr.2402275


Latest estimates indicate that 5-7% of the population are living with Alzheimer’s disease and related dementias worldwide with a doubling in incidence expected every 20 years. Rehabilitation professionals are challenged with the complex needs of these patients. It is commonly thought that patients with dementia do not benefit from rehabilita [...]
Open Access Perspective

Vascular Risks, Aging, and Late-Onset Dementia: Overlapping Etiologies Point to 'Scavenger Receptor'-Mediated Therapeutics

Received: 25 March 2023;  Published: 04 August 2023;  doi: 10.21926/obm.geriatr.2303244


Early changes in systemic vascular stiffness and endothelial function can contribute to altered cerebrovascular hemodynamics and impaired cognitive function; additionally, these vascular changes point to potential targets for prevention and treatment strategies in people with mild cognitive impairment. Although the pathogenic mechanisms underl [...]