Brief Review: Pancreatic Islet Transplantation for Type 1 Diabetes in Humans
Abstract
(ISSN 2577-5820)
OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
OBM Transplantation is committed to rapid review and publication, and we aim at serving the international transplant community with high accessibility as well as relevant and high quality content.
The journal publishes all types of articles in English. There is no restriction on the length of the papers. We encourage authors to be concise but present their results in as much detail as necessary, as reviewers are expected to emphasize scientific rigor and reproducibility.
Publication Speed (median values for papers published in 2023): Submission to First Decision: 6.7 weeks; Submission to Acceptance: 14.4 weeks; Acceptance to Publication: 6 days (1-2 days of FREE language polishing included)
Special Issue
Current Advancement of Islet Cell Transplantation in the Treatment of Diabetes Mellitus 2.0
Submission Deadline: March 15, 2025 (Open) Submit Now
Guest Editor
Preeti Chhabra, PhD
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
Publications: https://www.ncbi.nlm.nih.gov/myncbi/preeti.chhabra.1/bibliography/public/
Research Interests: Type 1 diabetes; immunotherapies; COVID-19 treatments; Micriobiome and microRNA biomarkers; Proteomics; Islet transplantation; Immunoglobulin M
About This Topic
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune destruction of insulin-producing beta cells that results in the progressive loss of insulin secretion and glycometabolic control. According to the Collaborative Islet Transplant Registry, approximately 1.9 million Americans have T1DM, with this number expected to rise to 5 million by the year 2050. For patients with hyper-labile diabetes that experience recurrent life-threatening hypoglycemic episodes and reduced hypoglycemic awareness, and who are refractory to conventional means of stabilizing glycometabolic control, clinical islet transplantation represents a safe and effective treatment option. The benefits of the procedure include lowering of daily Insulin requirements, improved levels of glycated hemoglobin, reduced number of hypoglycemic episodes and unawareness, improved quality of life, and potential insulin independence. The remarkable advances made during the last decade indicate we are well on our way to transitioning clinical islet transplantation into a widespread and fundable option for curing T1DM.
Keywords
Islet transplantation; Autotransplantation; Allotransplantation; Insulin independence; Hypoglycemic episodes; Pancreas procurement, islet processing and infusion characteristics; Induction and maintenance immunosuppression; Graft function; Immunotherapies; Strategies promoting graft survival; Stem cells
Manuscript Submission Information
Manuscripts should be submitted through the LIDSEN Submission System. Detailed information on manuscript preparation and submission is available in the Instructions for Authors. All submitted articles will be thoroughly refereed through a single-blind peer-review process and will be processed following the Editorial Process and Quality Control policy. Upon acceptance, the article will be immediately published in a regular issue of the journal and will be listed together on the special issue website, with a label that the article belongs to the Special Issue. LIDSEN distributes articles under the Creative Commons Attribution (CC BY 4.0) License in an open-access model. The authors own the copyright to the article, and the article can be free to access, distribute, and reuse provided that the original work is correctly cited.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). Research articles and review articles are highly invited. Authors are encouraged to send the tentative title and abstract of the planned paper to the Editorial Office (transplantation@lidsen.com) for record. If you have any questions, please do not hesitate to contact the Editorial Office.
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Publication
Brief Review: Pancreatic Islet Transplantation for Type 1 Diabetes in HumansAbstract Pancreatic islet transplantation (ITx) has moved from the experimental phase of development to a position of an accepted and appropriate procedure to apply in clinical medicine. The primary indication for use of ITx is for management of dangerous and recurrent hypoglycemia secondary to use of exogenous insulin for management of hyperglycemia [...] |
2023 | ||
CiteScore | SJR | SNIP |
0.6 | 0.179 | 0.17 |
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