OBM Transplantation is an international peer-reviewed Open Access journal, which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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Current Advancement of Islet Cell Transplantation in the Treatment of Diabetes Mellitus 2.0
Submission Deadline: March 15, 2023 (Open) Submit Now
Preeti Chhabra, PhD
Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
Research Interests: Type 1 diabetes; immunotherapies; COVID-19 treatments; Micriobiome and microRNA biomarkers; Proteomics; Islet transplantation; Immunoglobulin M
About This Topic
Type 1 diabetes mellitus (T1DM) is caused by the autoimmune destruction of insulin-producing beta cells that results in the progressive loss of insulin secretion and glycometabolic control. According to the Collaborative Islet Transplant Registry, approximately 1.9 million Americans have T1DM, with this number expected to rise to 5 million by the year 2050. For patients with hyper-labile diabetes that experience recurrent life-threatening hypoglycemic episodes and reduced hypoglycemic awareness, and who are refractory to conventional means of stabilizing glycometabolic control, clinical islet transplantation represents a safe and effective treatment option. The benefits of the procedure include lowering of daily Insulin requirements, improved levels of glycated hemoglobin, reduced number of hypoglycemic episodes and unawareness, improved quality of life, and potential insulin independence. The remarkable advances made during the last decade indicate we are well on our way to transitioning clinical islet transplantation into a widespread and fundable option for curing T1DM.
Islet transplantation; Autotransplantation; Allotransplantation; Insulin independence; Hypoglycemic episodes; Pancreas procurement, islet processing and infusion characteristics; Induction and maintenance immunosuppression; Graft function; Immunotherapies; Strategies promoting graft survival; Stem cells
Received: 13 February 2023; Published: 17 May 2023; doi: 10.21926/obm.transplant.2302184
Pancreatic islet transplantation (ITx) has moved from the experimental phase of development to a position of an accepted and appropriate procedure to apply in clinical medicine. The primary indication for use of ITx is for management of dangerous and recurrent hypoglycemia secondary to use of exogenous insulin for management of hyperglycemia [...]
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