Open Access Original Research

A Phase I/II Randomized Trial of Higher Dose mRNA-1273 Boosters in Lung Transplant Recipients

by Michael Y. Shino  , Francisco Javier Ibarrondo  , Jesse L. Clark  , Adreanne Rivera  , Marlene Florian  , Allison Ramsey  , Ariss Derhovanessian  , Rajan Saggar  , Olawale O. Amubieya  , Grant Turner  , Joanna M. Schaenman  , Pryce T. Gaynor  , Omer E. Beaird  , Ashrit Multani  , Reshma M. Biniwale  , Murray H. Kwon  , Christos J. Petropoulos  , Yolanda Lie  , Terri Wrin  , Amparo L. Figueroa  , Brett Leav  , Zelalem Endale  , Kate Anteyi  , Jacqueline M. Miller  , Abbas Ardehali  , David M. Sayah  , David Elashoff  , John A. Belperio  , Otto O. Yang  and S. Sam Weigt

Received: 16 August 2024;  Published: 20 November 2024;  doi: 10.21926/obm.transplant.2404227

Abstract

Higher-dose mRNA booster vaccines have not been well studied for transplant recipients. This study evaluated the safety, reactogenicity and immunogenicity of higher dose mRNA-1273 booster vaccines among lung transplant recipients (LTRs). This phase 1/2 open-label randomized clinical trial of higher- [...]

73 514

Open Access Research Article

Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimen

by Sabrine Mekni  , Lamia Torjemane  , Malek Khayati  , Dorra Belloumi  , Rimmel Yosra Kanoun  , Insaf Ben Yaiche  , Rihab Ouerghi  , Ines Turki  , Saloua Ladeb  , Tarek Ben Othman  and Nour Ben Abdeljelil

Received: 29 June 2024;  Published: 11 November 2024;  doi: 10.21926/obm.transplant.2404226

Abstract

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This stu [...]

83 571

Open Access Case Report

Use of Plasma-Rich in Growth Factors (PRGF) in the Treatment of Acne

by Elga J. Vargas  , Julio C. Martinez  and Lina A. Gomez

Received: 26 April 2024;  Published: 03 October 2024;  doi: 10.21926/obm.transplant.2404225

Abstract

Acne is a chronic inflammatory condition affecting the pilosebaceous units of the skin, characterized by the formation of papules, cysts, comedones, pustules, nodules, and scars. These lesions are typically located on the face and shoulders, although they can extend to the trunk, arms, and legs. In [...]

145 923

Open Access Review

Current and Future Applications of Machine Perfusion and Other Dynamic Preservation Strategies in Liver Transplantation

by Yue Qiu  , Yinqian Kang  , Hao Liu  and Ibtesam Hilmi

Received: 12 May 2024;  Published: 30 August 2024;  doi: 10.21926/obm.transplant.2403224

Abstract

Machine perfusion (MP) techniques, which simulate physiological conditions to allow for the assessment and preservation of organ viability, are currently applied in various solid organ transplantation fields. Owing to the growing demand for liver transplants and [...]

149 1358

Open Access Review

Platelets as Regenerative Cells, Hundreds of Opportunities in Sight

by Elga Johanna Vargas  , Ana Luisa Muñoz  and Lina Andrea Gómez

Received: 21 May 2024;  Published: 13 August 2024;  doi: 10.21926/obm.transplant.2403223

Abstract

Platelets were the last to be discovered of the three formed blood elements. Several scientists have been interested in them, recognizing them as cells other than leukocytes and erythrocytes. Its job in hemostasis and thrombosis is currently known. Platelets contain growth factors and secrete cytoki [...]

114 1083

Open Access Review

Machine Perfusion of Donor Hearts – The Recovery and Transplantation of Previously Unrecoverable Hearts

by Sanjay Dutta  , Jeanette E. Villanueva  , Yashutosh Joshi  , Ling Gao  , Paul Jansz  and Peter S. Macdonald

Received: 02 April 2024;  Published: 05 August 2024;  doi: 10.21926/obm.transplant.2403222

Abstract

Heart transplantation remains the gold standard treatment for end-stage heart failure. With an increasing population and improving medical therapy there is an increasing number of patients who would benefit from heart transplantation but are unable to receive one due to a shortage of sui [...]

160 1377

Open Access Review

BK Virus-Associated Nephropathy in Adult Patients Post Kidney Transplantation: What Progress in 30 Years of History?

by Yassamine Bentata

Received: 24 January 2024;  Published: 25 July 2024;  doi: 10.21926/obm.transplant.2403221

Abstract

Completely unknown before the 90s and exceptional up to the 2000s, BK virus nephropathy (BKvN), usually known as polyomavirus-associated nephropathy, has emerged as a significant and severe viral complication in kidney transplantation (KT). More than twenty years after Gardner's discovery of BKv in [...]

185 1483

Open Access Research Article

Impact of Intravenous Immunoglobulin Replacement Therapy on Hypogammaglobulinemia and Infection in Lung Transplant Recipients

by Van Anh Vu  , Joelle Nelson  , Helen Sweiss  , Reed Hall  , Holly Keyt  and Elisabeth Kincaide

Received: 29 January 2024;  Published: 03 July 2024;  doi: 10.21926/obm.transplant.2403220

Abstract

Secondary hypogammaglobulinemia (HGG) from immunosuppression therapy in lung transplant recipients has been associated with increased mortality, morbidity and higher risk of infection. Intravenous immunoglobulin (IVIG) for the treatment of HGG post-lung transplant is not well studied wit [...]

180 1557

Open Access Original Research

Detection of Activated Pepsin in Bronchoalveolar Lavage and Acute Cellular Rejection in Lung Transplant Recipients

by Andrés R. Latorre-Rodríguez  , Devika Sindu  , Sumeet K. Mittal  and Ashwini Arjuna

Received: 23 February 2024;  Published: 21 June 2024;  doi: 10.21926/obm.transplant.2402219

Abstract

Activated pepsin (pepA) in bronchoalveolar lavage (BAL) fluid may be a biomarker of gastric aspiration. We sought to i) evaluate the association of pepA in BAL fluid with acute cellular rejection (ACR) in a cohort of lung transplant recipients (LTRs), ii)&l [...]

Open Access Case Report

Management of Calcareous Corneal Degeneration from Medication Washout to Corneal Transplantation. Case Series and Review of the Literature

by Filippo Lixi  , Benedetta Pintus  and Giuseppe Giannaccare

Received: 27 February 2024;  Published: 07 June 2024;  doi: 10.21926/obm.transplant.2402218

Abstract

Calcareous corneal degeneration is a rare disease characterized by calcium phosphate deposition into the deep corneal layers. Corneal calcification has a multifactorial origin and is associated with various systemic and ocular conditions. Several treatment options showed promising results in the man [...]

201 1785