Moderate Exercise Suppresses Tumor Growth and Progression through Regulating Cytokines
Abstract
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Moderate Exercise Suppresses Tumor Growth and Progression through Regulating CytokinesAbstract
Evidence suggests that regular moderate exercise can improve symptoms of depression and may enhance immune function, with an interesting role in cancer prevention and improved cancer-related prognosis; however, over-exercising may lead to overtraining and generate psychological symptoms that mimic depression, and may impair immune function. In this study, we chose swimming as an exercise form to conduct research. Swimming groups were divided into 5, 20, and 60 min day-1, and open field tests (OFT) were used to asse [...] 994 4713 |
Correction: Tse et al. How COVID-19 Ceases All Older Adult Services & the Way Out for Community-Dwelling Older Adults with Chronic Pain. OBM Neurobiology 2023; 7: 183by
Abstract
CorrectionCorrection: Tse et al. How COVID-19 Ceases All Older Adult Services & the Way Out for Community-Dwelling Older Adults with Chronic Pain. OBM Neurobiology 2023; 7: 183Mimi Mun Yee Tse 1, *, Shamay Sheung Mei Ng 2, Vivian Lou 3, Raymond SK Lo 4, Daphne Sze Ki Cheung 5, Paul H Lee 6, Shuk Kwan Tang 7, Siu Hang Leung 1, Percy Poo-See Tse 1* Correspondence: Mimi Mun Yee Tse; E-Mail: mmytse@hkmu.edu.hkAcademic Editors: Ines Testoni, Adriano Zamperini and Lorenza PalazzoSpecial Issue: How COVID-19 Changed Indi [...] 994 4775 |
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Open Access Short Communication Surgical Tips for Improving Success Rate of Deep Anterior Lamellar Keratoplasty in Keratoconusby
Abstract
This article aims to provide some personal surgical tips to increase the success rate of deep anterior lamellar keratoplasty (DALK), a very advantageous yet complex procedure for treating keratoconus. The most troublesome surgical step is obtaining a successful pneumatic dissection of the deep stromal tissue, allowing the exposure of a deep cleavage plane. The following tips may aid the trainee surgeon in mastering this step, among others: performing a deep trephination, using intraoperative anterior segment optica [...] 994 7171 |
World Federation of Acupuncture-Moxibustion Societies (WFAS)/Acupuncture Science Association Sweden (ASAS) 2025 International Congress – Personal Report1Abstract
This personal report summarizes the key experiences and insights gained from attending the 2025 International Symposium organized by the World Federation of Acupuncture-Moxibustion Societies (WFAS) and the Acupuncture Science Association of Sweden (ASAS), held in Stockholm. The event brought together international experts to explore recent advances in acupuncture research, clinical applications, education, and global integration. Despite notable challenges—including issues with AI-assisted real-time translation and [...] 992 4893 |
Anxiety, Stress and Depression as the Notorious Barriers to Achieving a Massive Performance among Egyptian Construction Site WorkersAbstract
In today's corporate landscape, optimizing performance has emerged as a formidable challenge for organizations, often hindered by formidable barriers and psychological factors. This study explores the role of anxiety, stress, and depression in attaining performance among Egyptian construction site workers. The quantitative analysis utilizes cross-sectional data collected from workers working at different construction sites in Egypt. The study concludes with findings from 298 valid cases. Leveraging the structur [...] 992 7557 |
Unraveling Bioactive Constituents Isolated from Knema hookeriana Warb. as Potential Acetylcholinesterase Inhibitorsby
Abstract
The Myristicaceae family, particularly the Knema genus, is renowned for its diverse bioactive compounds, including lignans, flavonoids, and phenolics. This study explores the phytochemical profile of Knema hookeriana Warb. leaves and evaluates their potential as acetylcholinesterase (AChE) inhibitors. Phytochemical extraction was performed using a cold maceration method with a polarity-gradient solvent system (hexane, ethyl acetate, and methanol). The isolated compounds were purified through chromatographic techniq [...] 992 5780 |
Health Outcomes Associated with Community Senior Center Fitness Classes: Influence of Activity Type and Baseline Physical Activity LevelAbstract
Senior centers serve as community anchors for the approximately 57.8 million older adults in the U.S., offering a range of health promotion programs, including exercise classes. This study examined how the type of exercise programs at senior centers influences older adults’ health (mental, physical, and quality of life) and how baseline physical activity levels may influence these changes as part of a statewide health promotion program evaluation in senior centers in Delaware. The exercise programs offered were bas [...] 991 4550 |
Dependence Levels and Oral Functionality in Older Peopleby
Abstract
It has been suggested that an individual's overall functional capacity gradually declines with age. It has been reported that a decline in oral functionality increases the risk of sarcopenia and frailty, which contributes to the decrease in functional capacity. In Chile, the Preventive Medical Examination for Older Adults (EMPAM) is used to assess the functionality of that population; however, this examination does not include an evaluation of oral functionality. To address this gap, the Preventive Dental Examinati [...] 990 3840 |
Acknowledgment to Reviewers of Catalysis Research in 2024Abstract
The editors of Catalysis Research would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2024. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can sign up to the Web [...] 987 3823 |
The Heavy Burden of Judgement: Cultivating Compassion with People Accessing Healthcare Services for Support with Weight ManagementAbstract
Compassion focused therapy concepts and techniques are explored in the context of weight management efforts within community, specialist and surgical settings. Living at higher weights within a culture that over-values life at low weights can induce feelings of shame, self-loathing and hypercriticism. This article examines points at which individuals engaging in weight management may experience heightened distress and describes some of the ways that the model has been applied with this population. An outline of the [...] 987 6079 |
Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Fanconi Anemia: Results of a Single Center with a Fludarabine-Based Conditioning Regimenby
Abstract
Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) remains the only curative treatment for bone marrow failure (BMF) and hematologic complications of Fanconi anemia (FA). The evolution remains affected by the toxicity, the risk of graft failure, and clonal evolution. This study aimed to identify factors affecting outcomes in FA patients after allo-HSCT. We included FA patients who underwent allo-HSCT between January 2006 and December 2021. The conditioning regimen was cyclophosphamide/fludarabine (Cy/Fl [...] 987 5741 |
What Is the Current Status of Single Lung Transplantation? A Literature Reviewby
Abstract
Lung transplantation (LTx) is the gold standard for the surgical treatment of end-stage lung disease. Ongoing discussions persist whether single lung transplantation (SLT) or bilateral lung transplantation (BLT) lead to better patient outcomes and quality of life. This study analyzed 58 peer-reviewed articles from 1990 to 2024, comparing SLT and BLT across several parameters, including indications for transplantation, overall survival, pulmonary hypertension, complications, chronic rejection, functional status, and [...] 986 10703 |
Energy Self-Sufficiency in Rural Areas; Case Study: North Euboea, Greeceby
Abstract
The modern globalized civilization is sustained by interactions, trade, the transportation of goods, and energy. Energy self-sufficiency is crucial in rural and disaster-prone areas like North Euboea because dependence on external energy supplies can leave regions vulnerable to supply chain disruptions, price volatility, and geopolitical risks. In such isolated regions, energy independence ensures resilience in natural disasters and economic instability. The alternative to self-sufficiency often involves reliance o [...] 985 7793 |
Efficacy of Motor Imagery in the Rehabilitation of Stroke Patients: A Scope Reviewby
Abstract
This review examines the efficacy of motor imagery (MI) as a supplementary rehabilitation technique for stroke patients. Nine randomized controlled trials (RCTs) were analyzed, highlighting MI's potential to enhance motor recovery, mobility, balance, and psychological well-being. Significant improvements in upper-limb function were observed with combined mental and physical practice, evidenced by notable gains in Fugl-Meyer Assessment (FMA) and Action Research Arm Test (ARAT) scores. MI-based exercise programs impr [...] 982 16248 |
Teachers Experiences in Mindfulness and Fitness Program: A Pilot StudyAbstract
Current research shows that mindfulness and physical training programs have been shown to help reduce stress independently, however, limited research is available exploring the possible additive effects of implementing both training programs together [1, 2]. To test the feasibility and effectiveness of the Mind-Body Fitness program through a case-series pilot program, seven elementary school teachers completed a nine-week mindfulness and fitness program. The Perceived Stress Scale [3] was administered at three time [...] 979 6542 |
A Systematic Literature Review for the Development of a Consolidated Method for DLCAAbstract
Dynamic Life Cycle Assessment (DLCA) is an emerging approach in the construction industry it is. Yet, current research is often limited, overlooks operational patterns, and relies on generic case studies, highlighting the need for an extended method to apply these analyses in the built environment. This study conducts a Systematic Literature Review to evaluate the current state of DLCA research and identify key steps toward developing a unified and globally applicable methodology. Using the PRISMA protocol, 69 peer [...] 979 4700 |
Rejuvenating the Skin: The Role of Macro and Microalgae in Preventing AgingAbstract
The increasing consumer demand for cosmetic products has led to the widespread use of synthetic substances, which are inexpensive and readily available but can sometimes harm the skin and body. Examples include hydroxybenzoic acid esters (parabens) and phthalates, which are considered endocrine disruptors, and synthetic fragrances that may cause irritation or allergies. Consequently, there has been a shift in consumer preferences towards natural cosmetic products. In response to this demand and the expanding market [...] 977 8530 |
Research on the Whole Life Cycle Assessment of Automobile Instrument Cross Beam Based on LightweightAbstract
To study the environmental impact of automobile components, life cycle assessment (LCA) is adopted to study the environmental impact of instrument cross beams made of steel and magnesium alloy crossbeams. Comparative environmental impact analyses of both instrument crossbeams are conducted through parametric analysis, scenario analysis, sensitivity analysis, and future forecasting in GaBi10. The results show that global warming potential (GWP), acidification potential (AP), eutrophication potential (EP), ozone depl [...] 976 6448 |
An Application of Excess Solar and Storage Capacity Optimization for Grid Servicesby
Abstract
This initiative aims to enhance the efficiency of utility demand response (DR) operations by coordinating and integrating behind-the-meter (BTM) photovoltaic systems (PV) and energy storage (ES) using innovative machine learning software applications embedded in a distributed control architecture. The project is in the process of creating distributed energy resource (DER) learning agents and optimization engine within a hierarchical and layered distributed control architecture (DCA). These components work together [...] 976 5449 |
Is Stimulant Treatment in Children and Adolescents with Mood Dysregulation Associated with Adverse Outcomes?by
Abstract
The aim of this paper is to examine effects of stimulant treatment in children and adolescents with high levels of emotional dysregulation in a psychiatric outpatient clinic. Subjects were referred children and adolescents 6-17 years of age who presented to a child psychiatric outpatient clinic between September 2016-November 2021 and received a prescription for a stimulant medication. Children were stratified into those with low and high levels of emotional dysregulation as defined by an aggregate T-score of <1 [...] 975 6283 |
Correction: Armstrong C. Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic Perspective. OBM Integrative and Complementary Medicine 2021; 6: 16Abstract
CorrectionCorrection: Armstrong C. Unity, Continuity, Structure, and Function. The Ongoing Search for a Deeper Understanding of the Many Roles Attributed to Fascia in the Living Human Body - An Osteopathic Perspective. OBM Integrative and Complementary Medicine 2021; 6: 16Colin Armstrong *Osteopathic Centre, 1732 Voie Aurelienne, 13450 Grans, France; E-Mail: arm.colin@gmail.com*Correspondence: Colin Armstrong; E-Mail: arm.colin@gmail.comAcademic Editor: Nancy Nies Byl Special Issue: The Importance of the Fascia for [...] 974 6328 |
Successful Treatment of a Pregnant Woman with Chronic Active Hepatitis B using Tenofovir Disoproxil Fumarateby
Abstract
(1) Background: Infection with hepatitis B virus (HBV) infection during pregnancy occasionally raises concerns, including acute exacerbation and the potential for mother-to-child transmission.
(2) Case Report: Here, we present a case of a female patient with a chronic HBV infection who was treated with tenofovir disoproxil fumarate (TDF) and had a normal pregnancy and delivery. Furthermore, the use of TDF, HBV vaccination and passive immunization of her child with hyperimmune hepatitis B immunoglobulin successfully [...] 970 5991 |
Effect of EVA on the Unnotched Impact Toughness of PP/HDPE/EVA Blendsby
Abstract
Beverage bottle caps are usually made from two primary materials: PP and HDPE. In this study, the evaluation criteria were the unnotched impact toughness and the microstructure of PP/HDPE/EVA samples produced by injection molding. The samples were tested according to ASTM D256. PP/HDPE/EVA blends were prepared with various ratios: 47.5/47.5/5, 45/45/10, 42.5/42.5/15, 40/40/20, and 37.5/37.5/25. The results showed that adding EVA to the PP/HDPE blend significantly increased the unnotched impact toughness: from 84.03 [...] 969 4534 |
The Dynamics of the Oceanic Air-Sea Boundary LayerAbstract
This paper presents a model for the similarity structure of the velocity profiles in air and water in the wave boundary layer, which provides predictions in terms of two parameters, F and R, of all its important properties, including the Charnock parameter, the surface drift velocity and the condition for the cancellation of the surface Stokes velocity by the surface current. The parameter, F, arises from the fetch variability of the wave field, and the parameter, R, arises from the duration variability of the wave [...] 968 6029 |
An Interview with Prof. Vincenzo M. SglavoAbstract
An Interview with Prof. Vincenzo M. Sglavo. 968 6050 |
Finding Positives Amidst the Negatives: A Thematic Analysis of the Impact of the COVID-19 Pandemic on Canadians 55+Abstract
Disasters such as the COVID-19 pandemic exact a toll on vulnerable populations in terms of morbidity and mortality, but they also provide opportunities for personal growth and development and demonstration of personal and collective resiliency. This inductive thematic analysis explores self-perceived negative and positive impacts of the COVID-19 pandemic on 2994 Canadians aged 55+. Data derive from response to two open-ended questions included in a national online survey (View Survey (sfu.ca)) conducted between Aug [...] 967 7980 |
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Open Access Short Communication Good or Great: Which One Are You?Abstract
Clinicians caring for patients, especially those with chronic diseases or older adults, need to recognize the value of being able to transition away from aggressive care when appropriate and focus on a more palliative approach. Research has shown that patients want to have goals of care discussions and maintain autonomy at the end of life. These goals of care discussions can be challenging, and clinicians must prioritize and develop this skill in order to provide their patients with what they may need most. Being a [...] 966 4480 |
Improving Outcomes in Elderly Patients with Ovarian and Pancreatic Cancer through Multimodal Prehabilitationby
Abstract
Elderly patients with ovarian and pancreatic cancer frequently experience malnutrition and sarcopenia, which negatively impact treatment tolerance, functional outcomes, and survival. The increasing use of neoadjuvant chemotherapy in this population necessitates structured interventions to mitigate these challenges. While prehabilitation has shown promise in enhancing treatment tolerance and quality of life, its role during chemotherapy remains underexplored. This prospective study evaluates the feasibility and impa [...] 966 5558 |
Mental Health Service Users' Experiences of Receiving Ear Acupuncture as a Complement in Psychiatric Care in ICELAND – A Qualitative and Quantitative Pilot Studyby
Abstract
Depression, insomnia, cravings, and anxiety are significant and often long-lasting health problems. As medication has limited effect and often side effects, complementary methods such as ear acupuncture are used in mental health care. To describe mental health care users' experiences of ear acupuncture, including ratings of sleep, anxiety, depression, stress, pain, and cravings. This mixed methods study included in- and outpatients at a mental health rehabilitation service in Iceland. Standardized ear acupuncture ( [...] 965 7273 |
Opioid-Involved Elder Abuse in the United States: Perspectives from Adult Protective ServicesAbstract
The purpose of this descriptive study was to understand the nature, extent, and challenges confronted by APS programs in the United States in providing services to older clients affected by opioids. The study design involved a two-step process: Phase I involved telephone interviews with state-level Adult Protective Services administrators from 11 states considered to be “hot-bed states” for the opioid epidemic. Findings from the administrator interviews informed questions for Phase II telephone interviews with indi [...] 964 4766 |
Molecular Cytogenetic Characterization of Rare but Repeatedly Observed TranslocationsAbstract
Balanced chromosomal rearrangements, including translocations, contribute to infertility, repeated abortions, and/or genetically imbalanced offspring in corresponding carriers. A translocation is usually considered a unique, de novo, or familial event. Besides, some translocations have also been shown to develop multiple times with slightly different or even identical breakpoints; for others, founder effects have been suggested. Here, two known recurrent translocations [t(11;22)(q23.3;q11.21) and der(X)t(X; Y)(p22. [...] 963 4643 |
Serum Shock Enhances Endogenous Melatonin Production and Mitochondrial Gene Regulation in U87-MG Glioblastoma Cellsby
Abstract
Glioblastoma (GBM) is the most aggressive primary brain tumor, with a poor prognosis despite advancements in understanding its biology. Melatonin, a key regulator of metabolism and cellular homeostasis, is known for its neuroprotective and anti-cancer properties. While traditionally linked to pineal gland secretion, emerging evidence suggests that glioblastoma cells can produce melatonin within their mitochondria. This study investigates whether serum shock can influence endogenous melatonin production and mitochon [...] 961 4271 |
Acknowlegement to Reviewers of OBM Neurobiology in 2020Abstract
The editors of OBM Neurobiology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2020. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers receive a voucher entitling them to a discount on their next LIDSEN publication and can download a certificate of recognition di [...] 961 6143 |
Management of Steatosis in Living Donors: Where Do We Stand?Abstract
With the progressive rise in rates of liver transplantation, stagnant donor pool, and social factors, living donor liver transplantation (LDLT) forms the majority of liver transplantations performed in Asian countries. As the global prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing, around 17-25% of all the prospective donors turn out to be steatotic at the time of evaluation and, as such, rejected for donor hepatectomy, thereby considerably reducing the living donor pool. Steatotic graft [...] 961 6512 |
Chest CT Scan Features of COVID-19 in a Hospitalized High-Altitude PopulationAbstract
There is a lack of knowledge regarding the type of lung compromise in high-altitude residents with COVID-19. This study aims to evaluate the lung compromise in chest CT scans of high-altitude dwellers hospitalized with COVID-19. Retrospective study that took place in "Daniel Alcides Carrión" Regional Hospital, located 3,250 meters above sea level in the city of Huancayo, Perú. 464 medical charts and chest CT images of hospitalized patients with confirmed COVID-19 from January to March 2021 were reviewed. The mean a [...] 956 4784 |
Mobilization of Autologous Peripheral Blood Stem Cells (PBSC) in CD20+ Lymphoma Patients Using RICE, Granulocyte-Colony Stimulating Factor (G-CSF) and PlerixaforAbstract
RICE is salvage therapy for treating CD20+non-Hodgkin lymphoma (NHL). It is combined with G-CSF to collect autologous peripheral blood stem cells (aPBSC). Little data exists, though, on the combination of G-CSF and Plerixafor after RICE in mobilizing adequate number of CD34 cells and the product’s immune content. We report on the results of twenty CD20+ NHL patients after RICE, G-CSF and Plerixafor were given to collect aPBSC. The median number of cells collected was 12.92 × 106 CD34 cells/kg (range 5.4 [...] 956 6755 |
Non Solved Contemporary Scientific Problems of Non-Conventional Bio-Surfaces LubricationAbstract
This paper presents new non solved, scientific research directions and their applications in contemporary non-conventional lubrication problems of the bio-surfaces domain. Here are described new research scientific trends and research problem solutions of hydrodynamic lubrication for living tissue, human skin and human cartilage joints surfaces. At first in introduction is described the state of the art, a new purpose of anticipate research and the bio-tribology connections with other scientific domains are documen [...] 953 7221 |
Advances in Managing Infections in Lung Transplantation: A Reviewby
Abstract
Transplanted lung allografts are particularly susceptible to infection among SOT due to the constant exposure to the environment, aggressive immunosuppressive strategies, and impaired clearance mechanisms after denervation of the transplanted lung. Though prophylactic antimicrobial, antifungal, and antiviral regimens are used as preventive strategies to mitigate the risk of infection, complications related to allograft infection remain one of the primary causes of morbidity and mortality after lung transplantation. [...] 953 6795 |
Air Pollution Control Engineering in Urban and Congested AreasAbstract
The study aims to evaluate the progressive increase in energy systems pollutant emissions due to the efficiency loss and continuous deterioration in the energy conversion process. The paper analyzes the GHG, nitrous oxide, sulfur dioxide, and fine particle emissions from vehicles, residential and commercial heating systems, public buildings, health centers, and industrial conglomerates, with the servicing time and degradation level. The analysis applies to various emitting gases or small particle systems, which gen [...] 952 3996 |
Potential Use of Human Mesenchymal Stem Cells (hMSCs) in Pancreatic Damage/CancerAbstract
Pancreatic damage and pancreatic cancer pose significant challenges due to their complex pathogenesis, limited treatment options, and poor prognosis. In recent years, the potential use of human Mesenchymal Stem Cells (hMSCs) has been explored to address these complex pancreatic conditions and develop novel therapeutics. hMSCs, known for their regenerative and immunomodulatory properties, offer a novel therapeutic avenue for repairing damaged tissues and possibly inhibiting cancer progression. This communication dis [...] 952 6549 |
Exploring the Unidimensionality of the GAD-7 for South African First Responders: Evidence from Multiple Psychometric ApproachesAbstract
Generalized Anxiety Disorder (GAD) is a prevalent mental health condition and the GAD-7 is widely used as a screening tool and measure of GAD severity. However, research has yielded conflicting findings regarding the factor structure of the instrument, with some studies supporting a unidimensional interpretation while others suggest a two-factor solution. These inconsistencies highlight the importance of validating the GAD-7 across diverse populations. This study aimed to assess the psychometric properties and fact [...] 952 5199 |
Importance of SLAPE Solar Panels, Electrochemical CO2 Reduction, Alkaline Electrolyzers and Alkaline Fuel Cells Development to Achieve United Nations Sustainable Development Goalsby
Abstract
The United Nations Organization (UNO) in the year 2015 formulated seventeen sustainable development goals (UNO’s 17 SDGs) to be achieved by the end of the year 2030. The so far achieved progress indicates that none of these UNO’s 17 SDGs can be achieved before the deadline. In fact, all these goals can be achieved by developing suitable technologies to fully capture and utilize all the renewable energy resources available on earth to meet all the energy needs of society without any backup from fossil fu [...] 952 5956 |
Synergistic Effect of Resveratrol and Paclitaxel in the Treatment of Malignant Pleural MesotheliomaAbstract
Malignant pleural mesothelioma (MPM) is a lethal and aggressive cancer due to exposure to asbestos since this carcinogen is still being used in industrial buildings and housing in several countries. Untreated MPM has a median survival time of 12 months, and most people die within 24 months after diagnosis. If caught early, surgery may be performed. Treatment option for palliative care is limited using platinum with pemetrexed. Malignant transformation of a cell is attributed to a series of genetic and epigenetic ev [...] 950 5581 |
Acknowledgment to Reviewers of Journal of Energy and Power Technology in 2023Abstract
The editors of Journal of Energy and Power Technology would like to express their sincere gratitude to the following reviewers for assessing manuscripts in 2023. We greatly appreciate the contribution of expert reviewers, which is crucial to the journal's editorial process. We aim to recognize reviewer contributions through several mechanisms, of which the annual publication of reviewer names is one. Reviewers can download a certificate of recognition directly from our submission system. Additionally, reviewers can [...] 949 4730 |
The Screening Strategies Used to Establish Egyptian Women Entrepreneurs’ Attitudes towards Genetic TechnologyAbstract
In this quantitative study, the researcher examined the screening strategies used to establish Egyptian women entrepreneurs' attitudes toward genetic technology. Using a questionnaire, the researcher collected data from 318 Egyptian women entrepreneurs. From applying the path analysis through Analysis of Moment Structures (AMOS) version 26.0, this study’s findings demonstrate genomic knowledge’s positive effect on attitudes towards genetic technology (β = 0.176; p = 0.003). The path analysis shows that, on the one [...] 948 4554 |
Exploring the Genetic Landscape of Knobloch Syndrome: Novel Variant Identification and Literature Reviewby
Abstract
Knobloch Syndrome (KS) is a rare genetic disorder characterized by ocular abnormalities and central nervous system (CNS) defects, which are attributed to collagenopathy. The primary gene implicated in KS is COL18A1, which encodes the alpha chain of type XVIII collagen. This type of collagen functions as a proteoglycan, predominantly located in the basement membrane of human tissues. This study examined an Iranian female presenting with symptoms of horizontal nystagmus, strabismus, and suspected vision loss, with a [...] 948 5710 |
Leveraging DNA Databases to Reconnect Families Separated by Conflicts and Humanitarian CrisesAbstract
Ongoing global conflicts and humanitarian crises have led to unprecedented displacement, including millions of separated children, many of whom, especially infants, cannot be traced using traditional methods. This paper advocates for the establishment of a voluntary, privacy-protected global DNA database, managed by an extra-governmental entity, to facilitate family reunification. It presents a comprehensive socio-technical framework that synthesizes a novel operational model with the requisite legal and ethical sa [...] 947 4840 |
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