by Sean J. O’Sullivan

Received: 17 June 2021;  Published: 17 November 2021;  doi: 10.21926/obm.genet.2104143

Advances in clinical psychiatry have been less than hoped for relative to the achievements in neuroscience. However, developments in neuromodulation and psychedelic therapy are promising. The efficacy of such treatments and canonical pharmacotherapies benefit from genetics and personalized medicine. Moreover, recent studies on the perturbation of transcription, including chromatin remodeling, in mental illness emphasized the importance of single-cell qPCR as an investigatory method that bolstered psychiatry. This t [...]

by Jacy C. Downey  and Clinton G. Gudmunson

Received: 19 October 2021;  Published: 29 January 2022;  doi: 10.21926/obm.icm.2201006

Parents model and teach early health practices that persist into adulthood by establishing a family culture through which children learn related family beliefs, values, and expectations. This phenomenological study examined the ways in which a purposefully selected group of mothers (selected due to their high scores on the Family Nutrition and Physical Activity screening tool) shaped family culture related to physical activity, addressed screen-time behaviors, and established positive eating related routines. Findi [...]

by Mieczyslaw Szyszkowicz  and Nicholas de Angelis

Received: 18 September 2021;  Published: 11 February 2022;  doi: 10.21926/aeer.2201005

Air pollution affects various aspects of human health. Here, the associations between the number of emergency department visits for circulatory and respiratory problems and ambient air pollution in Toronto, Canada, in the period between April 2004 and December 2015 were studied. The health data were linked with urban air pollution data and weather factors. The conditional Poisson regression models were built for 18 strata (sex, age group, season), 8 exposure factors (air pollutants, indexes), and their 15 lags (0-1 [...]

by Larissa Leandro da Cruz  , Gabriel Moreno Bernardo Gonçalves  , Silva Menezes de Faria Pereira  , Jamila Rodrigues Barboza  , Luana Pereira de Moraes  , Messias Gonzaga Pereira  , Marta Simone Mendonça Freitas  and Daniela Barros de Oliveira

Received: 30 December 2022;  Published: 27 August 2023;  doi: 10.21926/rpn.2303015

Sweet Corn (Zea mays L.) is possibly the most important commercial cereal originating in the Americas. Mutant genes are responsible for sweetness. The purpose of this study was to evaluate the physicochemical and mineral composition of the “UENF SD 08” cultivar, super-sweet corn developed at Darcy Ribeiro Northern Rio de Janeiro State University (UENF) and registered in the National Cultivar Register of the Ministry of Agriculture, Livestock, and Supply and to compare its content to commercial super-swe [...]

by Michael J Eiswerth  and Joel Wedd

Received: 30 November 2024;  Published: 17 April 2025;  doi: 10.21926/obm.transplant.2502247

The prevalence of alcohol use disorder (AUD) and alcohol-related liver disease (ALD) has increased in the last two decades. ALD is currently the most common indication for both waitlist additions and liver transplant (LT) in the United States, including alcohol-associated cirrhosis, alcohol-associated hepatitis (AH), and acute-on-chronic liver failure (ACLF). ALD also has a significant global disease burden. LT in ALD is a complex paradigm that poses both medical and ethical challenges, requiring a multidisciplinar [...]

by Jessica Lum  and Sherif B. Mossad

Received: 26 October 2018;  Published: 14 February 2019;  doi: 10.21926/obm.transplant.1901050

Despite the advances that have been made in the field of solid organ transplant (SOT), organ shortage remains a persistent problem. In addition, the donor pool has been changing with the ongoing opioid epidemic and increase in deaths related to drug overdose each year. More donors are meeting the 2013 United States (U.S.) Public Health Service criteria for increased risk donors (IRDs), or donors who are at higher risk for transmission of Human Immunodeficiency Virus (HIV), Hepatitis C virus (HCV), and other multidr [...]

by Peter Lechleitner

Received: 02 March 2018;  Published: 25 April 2019;  doi: 10.21926/obm.icm.1902027

The first part of this position paper focuses on the debate about the scientific status of homeopathy and presents some answers. The scientific debate however, does not represent the available scientific evidence, which actually supports our limited data. Thus, it seems important and we aim to present how homeopathy can be part of an integrated concept in cancer care and how this is approved by randomized controlled trials. We present some arguments which were helpful to us in the discussion with oncologists that d [...]

by Aghogho Ogwala  , Eugene Onori  , Cornelius Ogabi  , Oluwafunmilayo Ometan  , Yusuf Kayode  , Rasaq Adewemimo Adeniji-Adele  , Emmanuel Somoye  and Janet Odewale

Received: 13 September 2022;  Published: 05 December 2022;  doi: 10.21926/aeer.2204048

Ultraviolet (UV) and X-ray radiation are the primary causes of ionization that produce electron density in sufficient quantities to promote the propagation of satellite radio signals in the ionosphere. The electron densities suffer from spatio-temporal variations, and this poses different degrees of threats to satellite radio signals propagating through the ionosphere. We aimed to characterize the maximum electron density of the F2 layer (NmF2) in the middle-latitude ionosphere over Grahamstown, South Africa (Geogr [...]

by Deepti Singh Chalia  , Anil Khurana  , Mehul Trivedi  , Pinaken Trivedi  , Sarita Gola  and Parul Singh

Received: 20 February 2023;  Published: 28 June 2023;  doi: 10.21926/obm.icm.2302025

This retrospective data analysis study aims to analyze the data collected during adjunctive homeopathy treatment of COVID-19 patients by the Homoeopathic medical officers (HMO) in Gujarat state-dedicated COVID-19 hospitals (DCH) during the first wave of the pandemic. The HMOs used the standard data collection forms/sheets to record each patient's demographic information, clinical symptoms, homoeopathic management, and outcome data. Data of all cases hospitalized with COVID-19 of any age, and both genders were i [...]

by Michael Fossel

Received: 12 December 2017;  Published: 24 December 2017;  doi: 10.21926/obm.geriatr.1704003

by Seria Tsan  , Stefanie Kankel  , Niklas Padutsch  , Luisa Person  , Monika Ziegler  , Ahmed Al-Rikabi  , Anja Weise  , Kristin Mrasek  and Thomas Liehr

Received: 16 April 2021;  Published: 25 August 2021;  doi: 10.21926/obm.genet.2103135

Cryptic balanced chromosomal aberrations can be an underlying cause of infertility. In 2003 Cockwell and coworkers highlighted the relevance of euchromatic pericentric regions of acrocentric chromosomes that may be a yet ignored genomic region hosting cryptic rearrangements. Here we offer the first follow-up study to further explore this idea. Two specific molecular cytogenetic probe sets were established to elucidate such cryptic rearrangements together with chromosomal heteromorphisms of acrocentric centromeres. [...]

by Abdulmaleek Sado  , Rahul Kalla  and Simon Campbell

Received: 20 May 2019;  Published: 14 August 2019;  doi: 10.21926/obm.hg.1903032

Crohn's disease is part of a group of diseases termed inflammatory bowel disease. Guidelines have long advocated the use of steroids for acute flare up and Current goals of treatment include enhancing long-lasting remission, preventing relapse, reducing the need for surgery, preventing complications and slowing disease progression. No cure currently exists for the disease. Traditionally, the clinical approach to treatment has been symptom-based where patients have had to ‘earn’ their next treatment escalation. Howe [...]

by Federica Odaldi  , Vanessa De Pace  , Giacomo Frascaroli  , Giuliana Germinario  , Giorgia Comai  , Francesco Vasuri  , Gaetano La Manna  and Matteo Ravaioli

Received: 22 November 2019;  Published: 03 February 2020;  doi: 10.21926/obm.transplant.2001096

Donation after circulatory death (DCD) is an increasingly used resource to alleviate chronic renal graft shortages. Organs from donors with progressively increased creatinine levels due to acute kidney injury are used, but the effects of this condition on kidney transplantation are still unclear. Ex-situ machine perfusion is emerging as a potential tool to preserve and resuscitate vulnerable grafts. We report a case of DCD kidneys discarded due to severe acute kidney injury with favorable histological Karpinski sco [...]

by Farida Arisanti  , Tertianto Prabowo  , Putri Endyana  and Apichana Kovindha

Received: 03 October 2024;  Published: 18 March 2025;  doi: 10.21926/obm.neurobiol.2501279

Spinal tuberculosis (TB), an extrapulmonary manifestation of TB, primarily involves one or multiple vertebrae, with a high prevalence at the thoracolumbar region, which can compromise spinal cord integrity and result in severe sequelae such as paraplegia, bladder and bowel dysfunction, and mobility limitation. This study aimed to review medical, surgical, and rehabilitation management, clinical outcomes, and prognostic factors of spinal TB with spinal cord injury (SCI). Research was conducted utilizing databases su [...]

by Nadia A. Abdelmegeed Abdelwahed

Received: 01 April 2024;  Published: 19 August 2024;  doi: 10.21926/obm.neurobiol.2403241

Nowadays, mental health disorders have become a significant concern for everyone. There are diverse reasons emanating from the workplace, business, and everyday environment. Therefore, there is a current need to use technology to detect and review their symptoms and causes. Accordingly, in this study, the researcher attempted to recognize ChatGPT’s role in decision-making and the recognition of mental health disorders among Egyptian entrepreneurs. The researcher used a quantitative approach in this study based its [...]

by Richard Cheng  and Jon Kobashigawa

Received: 23 January 2019;  Published: 09 April 2019;  doi: 10.21926/obm.transplant.1902061

Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generation drug-eluting stents has been associated with high and unacceptable restenosis rates. However, second-generation drug-eluting stents are associated with favorable stent and lesion patency. Stent and lesion patency now [...]

by Vjollca Ndreu  , Yllka Themeli  , Ilirjana Zekja  and Fatjona Kamberi

Received: 02 April 2022;  Published: 06 July 2022;  doi: 10.21926/obm.neurobiol.2203126

The World Health Organization declared the COVID-19 pandemic on March 11th, 2020. The pandemic had significantly affected public health, and the mental health of people was compromised regardless of age or socioeconomic status. In this study, we measured the psychological distress caused by the pandemic and determined the associated factors. An online survey was conducted from November 16th (2020) to January 31st (2021). The participants were Albanian adults (≥18 years old). The call to participate was poste [...]

by Mauro Turrin

Received: 15 March 2019;  Published: 29 August 2019;  doi: 10.21926/obm.hg.1903034

Background: Among the rarest causes of acute pancreatitis, in addition to the drugs (DIAP), there are eosinophilic pancreatitis (EP) and autoimmune pancreatitis (AIP). Methods: we have researched on PUBMED the descriptions of clinical cases of eosinophilic pancreatitis appeared from 1990 to February 2019 and those related to new drugs responsible for acute pancreatitis. Results: we found about thirty reports of eosinophilic pancreatitis associated or not with hypereosinophilia and gastro-intestinal manifestations. [...]

by Anita Modi  and Sherif Beniameen Mossad

Received: 07 July 2019;  Published: 06 September 2019;  doi: 10.21926/obm.transplant.1903085

Chronic inflammatory states lead to T cell exhaustion, characterized by reduced T cell proliferation and activity. Immune checkpoint inhibitors (ICPI) reactivate T cells to restore the immune system’s natural defenses against foreign antigens. The widespread use of these agents in the treatment of malignancy has led to markedly reduced tumor burden and improved patient survival, sparking curiosity about their potential role in the treatment of other chronic inflammatory states, including infectious diseases. While [...]

by Hofit Edna Mashiah  and Susana Pendzik

Received: 25 May 2023;  Published: 11 July 2023;  doi: 10.21926/obm.icm.2303027

This paper follows a preliminary study that examined how 6 (n = 6) creative arts therapists (3 art therapists and 3 drama therapists) coped with the transition to remote therapy in schools during the first lockdown in Israel due to the Coronavirus pandemic. The preliminary research explored the therapists’ experiences and views about working online upon returning to regular in-person meetings. The current paper adds a follow-up interview examining their perspective on this period, two years later. The 1st set of in [...]

by Andreea L. Seritan

Received: 26 November 2021;  Published: 24 January 2022;  doi: 10.21926/obm.geriatr.2201187

Older adults’ mental health needs significantly increased during the COVID-19 pandemic. Geriatric psychiatry is an area of extreme workforce shortage globally. A novel curriculum was developed to educate healthcare providers on COVID-19-related geriatric and geropsychiatry topics. Monthly lectures were presented from November 2020 to June 2021. Evaluations were collected after each lecture via an anonymous survey. Overall lecture quality and relevance for the participants’ clinical practices were rated on a 1-3 Lik [...]

by Giorgos Mountrakis  and Sheng Yang

Received: 24 March 2021;  Published: 26 October 2021;  doi: 10.21926/aeer.2104026

While numerous studies have considered forest loss factors at local scales, there is a gap of comparative quantitative regional modeling at the U.S. national level. Here, we investigated statistical relationships between gross forest cover loss (GFCL) and numerous socioeconomic, biophysical and ownership variables between two decades, the 1990s and the 2000s. A spatial error model was employed to compensate for spatial autocorrelation effects. Models from the 2000s had stronger explanatory power than the 1990s mode [...]

by Morgan A. Valley  and Lorann Stallones

Received: 30 June 2021;  Published: 12 September 2021;  doi: 10.21926/obm.icm.2103029

Hospice care workers are exposed to the hazards associated with in-home care in uncontrollable environments as well as occupational stress related to caring for terminally ill patients and their families. This study aimed to assess the effectiveness of an abbreviated mindfulness intervention to improve hospice care worker occupational safety performance and well-being. This study used a single-group pre-post design to pilot test an 18-hour mindfulness training as an intervention on self-reported safety performance [...]

by Antoine Buemi  , Jérôme Duisit  , Flora Musuamba  , Tom Darius  , Martine De Meyer  , Selda Aydin  , Nada Kanaan  , Arnaud Devresse  , Eric Goffin  and Michel Mourad

Received: 13 January 2020;  Published: 13 May 2020;  doi: 10.21926/obm.transplant.2002109

This study aimed to investigate the outcomes of transplantation from donors aged less than three years in a single-center consecutive series. A total of 52 en bloc kidney graft transplantations were performed. In 22 cases, organs were procured from donors aged less than one year (group 1). In 30 cases, the age of donors varied from one to three years (group 2). After transplantation, renal function and graft and patient survival were evaluated retrospectively. No significant difference was observed between the grou [...]

by Michelle H. Dick  and Nayla M. Khoury

Received: 13 June 2019;  Published: 24 July 2019;  doi: 10.21926/obm.icm.1903047

We explore how medical culture contributes to burnout. Highlighting specific programs aimed at developing compassion and mindfulness skills, we share our own perspectives and experiences implementing similarly focused programs. Promising results on the application of compassion-based programs show evidence of improvements to a number of measures of trainee wellbeing, particularly among the most vulnerable trainees, while results pertaining to mindfulness programs show improvements to performance as well [1, 2]. As [...]