by Abdulmalik A. Lawan  and Nadire Cavus

Received: 31 May 2022;  Published: 30 September 2022;  doi: 10.21926/obm.neurobiol.2203138

Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved the clinical relevan [...]

by Anna A. Pendina  , Mikhail I. Krapivin  , Irina D. Mekina  , Irina V. Aleksandrova  , Yanina M. Sagurova  , Evgeniia M. Komarova  , Mariia A. Ishchuk  , Andrei V. Tikhonov  , Olesya N. Bespalova  , Alexander M. Gzgzyan  , Igor Yu. Kogan  and Olga A. Efimova

Received: 13 May 2022;  Published: 23 September 2022;  doi: 10.21926/obm.genet.2203164

This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggested for the successive detection of the catalytic telomerase subunit with immunohistochemical staining and assessment of telomere length with Q-FISH on the same set of cells. The described approach uses three incontestable advantages [...]

by Nicole Dawson  , Ashleigh Trapuzzano  and Katherine S. Judge

Received: 08 December 2023;  Published: 03 April 2024;  doi: 10.21926/obm.geriatr.2402275

Latest estimates indicate that 5-7% of the population are living with Alzheimer’s disease and related dementias worldwide with a doubling in incidence expected every 20 years. Rehabilitation professionals are challenged with the complex needs of these patients. It is commonly thought that patients with dementia do not benefit from rehabilitation because of cognitive decline, behaviors, lack of communication, or difficulties in learning; however, current literature indicates this is not accurate. With proper knowled [...]

by Isadora Muller de Oliveira  , Letícia Caroline de Oliveira Vital  , Izabela de Siqueira Reis Regueira  and Marcos Paulo Gomes Mol

Received: 02 July 2025;  Published: 11 November 2025;  doi: 10.21926/aeer.2504031

The management of healthcare waste (HCW) presents a significant environmental and public health challenge, aggravated by gaps in current Brazilian federal regulations. This study provides a comprehensive analysis of specific state and municipal legislation on HCW, comparing it with ANVISA Resolution No. 222/2018 and CONAMA Resolution No. 358/2005 to ascertain whether local regulations enhance management practices and can act as supplementary instruments to federal guidelines. The methodology was structured into thr [...]

by William Winlow  , Rouholah Fatemi  and Andrew S. Johnson

Received: 13 April 2023;  Published: 27 August 2023;  doi: 10.21926/obm.neurobiol.2303181

This review was constructed to show how the connectome has evolved in motor command systems from simple command elements to complex systems of neurons utilizing parallel distributed processing and the possibility of quantum entanglement between groups of neurons. Scientific and medical interest in neural pathways and their connections have driven neuroscience and brain research for many decades so that specific systems and their feedback loops have been considered in detail. We review motor command systems in inver [...]

by Dmitriy Melkonian  , Anthony Korner  , Russell Meares  and Anthony Harris

Received: 09 April 2023;  Published: 13 July 2023;  doi: 10.21926/obm.neurobiol.2303174

Traditional approaches to EEG modelling use the methods of classical physics to reconstruct scalp potentials in terms of explicit physical models of cortical neuron ensembles. The principal difficulty with such approaches is that the multiplicity of cellular processes, with an intricate array of deterministic and random influencing factors, prevents the creation of consistent biophysical parameter sets. An original, empirically testable solution has been achieved in our previous studies by a radical departure from [...]

by Adrian Krzysztof Antosik  , Karolina Mozelewska  and Marcin Bartkowiak

Received: 29 February 2024;  Published: 13 May 2024;  doi: 10.21926/jept.2402012

The investigation aimed to delve into the intricate relationship between the presence of titanium dioxide and the resulting alterations in the adhesive's behavior under different conditions. The focus extended beyond mere observation to understand how these additives interact with the adhesive matrix, potentially imparting beneficial attributes. Notably, the study delved into the optimization of thermal stability, the extension of the adhesive's functional lifespan, and the mitigation of shrinkage tendencies. This [...]

by Bernard R. Baum  and Douglas A. Johnson

Received: 07 January 2022;  Published: 24 April 2022;  doi: 10.21926/obm.genet.2202152

We have investigated the utility of the 5S nrDNA, a conserved, multicopy gene family organized into tandem repeats as a tool for genetic analyses in a wide variety of genera. Previous work in the Triticeae (Poaceae) demonstrated that the prior identification of unit classes based upon the 5S nrDNA NTS, greatly facilitates analysis. We investigated the potential of defining unit classes in other plant genera and several animal genera as a step towards future phylogenetic analyses. Our results demonstrate that in in [...]

by Giuseppe Cocco

Received: 20 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002112

by Richard A. Manfready  , Jack Husney  , Swan Thung  and Ilan S. Weisberg

Received: 04 March 2020;  Published: 25 September 2020;  doi: 10.21926/obm.hg.2003051

Patients receiving immunosuppressive therapy for inflammatory bowel disease may be susceptible to non-cirrhotic portal hypertension, now referred to as porto-sinusoidal vascular disease. Here we describe a patient treated with long-term azathioprine for Crohn’s disease who developed porto-sinusoidal vascular disease with obliterative portal venopathy without nodular regenerative hyperplasia on histology. Specific signs of portal hypertension were present, including porto-systemic collaterals on imaging. Histopathol [...]