by Emad Fadhal

Received: 18 January 2024;  Published: 24 May 2024;  doi: 10.21926/obm.genet.2402236

The RAS signaling pathway is a crucial cell transduction pathway central to transmitting signals from outside the cell to the cell nucleus and influencing fundamental biological mechanisms like cell growth, division, and specialization. This signaling pathway has recently received much attention in scientific research because of its involvement in various diseases, especially carcinogenesis. Our study identified the significance of crucial proteins in the RAS signaling cascade in cancer development and progression. [...]

by Abdulmalik A. Lawan  and Nadire Cavus

Received: 31 May 2022;  Published: 30 September 2022;  doi: 10.21926/obm.neurobiol.2203138

Autism spectrum disorder (ASD) is a neuropsychiatric disorder associated with critical challenges related to social, communication, and behavioral issues. Recent studies have proposed machine learning (ML) techniques for rapid and accurate assessment of ASD. However, the mismatch between the ML techniques and the clinical basis of ASD assessment reduces the effectiveness of ML-based assessment tools. The present study proposed an approach that utilized the potential of ML modeling and preserved the clinical relevan [...]

by Angela Cheng  , Xanthe Lea  and Alice Shires

Received: 13 March 2025;  Published: 23 June 2025;  doi: 10.21926/obm.icm.2502026

This study aims to investigate the barriers and facilitators to meditation in the general population. This research is significant because understanding these factors can inform the design of more effective public mental health interventions and support the integration of meditation into daily life. A qualitative thematic analysis was conducted on the qualitative component of wider survey responses. Participants were recruited from MeditationHQ, which offers weekly group meditation sessions on beaches around Austra [...]

by Mohammed Mustafa  , Salman Pervaiz  and Ibrahim Deiab

Received: 23 February 2024;  Published: 18 June 2024;  doi: 10.21926/rpm.2402013

This paper investigates the effect of rake angle, α, cutting edge radius, r, and feed rate, f, on the cutting force and cutting zone temperature during orthogonal dry cutting of Ti6Al4V. A numerical model representative of the 2D orthogonal cutting process is developed using ABAQUS/Explicit software. Johnson-Cook, (JC) constitutive material model is used to describe material plasticity. JC damage model and energy-based fracture criterion are used to describe damage initiation and evolution. Using Minitab-19 softwar [...]

by Samhani Ismail  , Muhammad Hakimi Mohd Nashron  , Mohd Hanifah Jusoh  and Abdul Nawfar Sadagatullah

Received: 26 February 2025;  Published: 05 August 2025;  doi: 10.21926/obm.neurobiol.2503296

Chronic pain involves complex cortical and subcortical changes, suggesting that brain electrical activity may be a potential biomarker for nociceptive processing. Pain leaves its signature in the brain's oscillatory patterns, yet limited studies have explored the neurophysiological alterations associated with chronic pain. This review examines the pain detection method currently used in clinical settings, the potential of neurophysiological features to become brain oscillatory brain biomarkers, and their use in fut [...]

by Koorosh Goudarzi  and Mohammad Reza Zare

Received: 19 April 2022;  Published: 08 June 2022;  doi: 10.21926/jept.2202020

Passenger and commercial internal combustion engines have relatively large dissipated thermal energy sources that can be used for initiating thermodynamic refrigeration cycles at low temperatures while improving engine efficiency. Researchers have focused on combined power-refrigeration cycles in past studies. This paper presents the operation and performance of a new combined refrigeration system driven by waste heat recovery within the internal combustion engines. For this purpose, the effects of several paramete [...]

by Andrey Nasledov  , Sergey Miroshnikov  , Liubov Tkacheva  and Sergey Fedorov

Received: 08 June 2023;  Published: 19 October 2023;  doi: 10.21926/obm.neurobiol.2304190

The study aims to reveal autism vectors that are inherent in 3-4-year-olds with ASD. Three hundred eighty-three children with ASD took part in the research. An online questionnaire developed earlier by our research group was used. In the first stage, with the repeated use of exploratory factor analysis, the task of identifying the simplest factor structure was solved. As a result, a 7-factor system was obtained, including from 9 to 14 items in each factor (78 items in total): 1) "Persistence on sameness" (Sam); 2) [...]

by Adrian Krzysztof Antosik  , Karolina Mozelewska  and Marcin Bartkowiak

Received: 29 February 2024;  Published: 13 May 2024;  doi: 10.21926/jept.2402012

The investigation aimed to delve into the intricate relationship between the presence of titanium dioxide and the resulting alterations in the adhesive's behavior under different conditions. The focus extended beyond mere observation to understand how these additives interact with the adhesive matrix, potentially imparting beneficial attributes. Notably, the study delved into the optimization of thermal stability, the extension of the adhesive's functional lifespan, and the mitigation of shrinkage tendencies. This [...]

by Sofie Amalie Andersson  , Mathias Møller Thygesen  , Anita Dittrich  and Henrik Lauridsen

Received: 07 March 2022;  Published: 06 July 2022;  doi: 10.21926/obm.neurobiol.2203127

The Mexican axolotl salamander is an important model species in regenerative medical research and experiments involving this species often require anesthesia which is usually limited to the duration of the surgical procedure or other interventions, usually lasting no more than a few hours. This study aimed to examine the potential for increasing the duration of anesthesia by continued propofol infusion for a week. Neurobehavioral changes in response to prolonged anesthesia were evaluated after two and seven days of [...]

by Renata Martins Pacheco

Received: 09 September 2022;  Published: 15 December 2022;  doi: 10.21926/aeer.2204051

Climate change is one of the main challenges of the current century. Emissions taxes are one of the proposed ways to help in addressing this issue. In this sense, Portugal has introduced an Addition Tax on Carbon Emissions through Law N. 82-D/2014. One of the most notorious impacts of climate change in the country is the wildfires increasing in frequency and intensity. Forests provide various ecosystem services not valued by traditional markets, such as carbon sequestration. Recently, Portugal has created new envir [...]