by Xiaofei Qin  , Yongren Feng  , Lejun Wu  , Zhongjian Tan  , Yanmin Zhou  and Wilson Chin

Received: 12 April 2023;  Published: 10 July 2023;  doi: 10.21926/jept.2303023

In conventional wireline and LWD/MWD formation testing, downhole predictions for rock and fluid properties are based on simplified Darcy flow models, but only for mathematical expediency. These require initially constant pressures that are uniform throughout the reservoir. This limitation precludes common applications in overbalanced drilling, so that supercharge or near-well invasion effects - associated with rapidly decreasing pressures at the sandface where pressures are measured - are completely ignored. Such 1 [...]

by Omotayo B. Ilesanmi  , Rosephine Enadeghe  , Chinenyenwa U. Aleneme  , Esther F. Adeogun  and Ufuoma J. Okotie

Received: 29 May 2022;  Published: 26 September 2022;  doi: 10.21926/obm.neurobiol.2203135

Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and Cd [...]

by Balamurugan Sivaprakasam  and Prasanna Sadagopan

Received: 24 December 2023;  Published: 14 June 2024;  doi: 10.21926/obm.genet.2402243

The present study introduces Snips2HLA-HsG, an integrated application designed for SNP genotype analysis and HLA allele type prediction. Leveraging attribute bagging, a powerful ensemble classifier technique from the Bioconductor HIBAG package, Snips2HLA-HsG offers a comprehensive response for genetic analysis. Accessible via https://snips2hla.shinyapps.io/hla_home/, the application distinguishes itself by prioritizing user-friendliness and integrating all-purpose functionalities, including sample preparation, mode [...]

by Hidehiro Kamezaki  , Tatsuo Kanda  , Osamu Yokosuka  , Yasunori Kasahara  and Takayuki Sakurai

Received: 16 November 2016;  Published: 21 January 2017;  doi: 10.21926/obm.hg.1701001

(1) Background: Preventative treatment for Pneumocystis jirovecii pneumonia (PCP) has been recommended for patients receiving ≥20 mg/day prednisolone. We describe a patient who developed PCP while receiving a dose of 15 mg/day prednisolone, and consider criteria for the initiation of preventative therapy for PCP in patients with autoimmune hepatitis (AIH) treated with prednisolone. (2) Case Report: A 71-year-old woman initially possessed dark-colored urine, white stool, and decreased appetite, which indicated hepat [...]

by Kristen R Szempruch  , Alec D Martschenko  , Harendra Arora  , Robert S Isaak  , Ravindra Prasad  , John L Schmitz  , Chuning Liu  , Fei Zou  and Pablo Serrano Rodriguez

Received: 13 February 2023;  Published: 18 April 2023;  doi: 10.21926/obm.transplant.2302181

Fluid management intra- and post-operatively for kidney transplant recipients (KTR) is essential to maintain adequate perfusion to the kidney. 0.9% normal saline (NS) is commonly used, but it can cause hyperchloremic metabolic acidosis, which may result in hyperkalemia and lead to delayed graft function (DGF). Plasma-Lyte A (PA) is an alternative option that has a lower amount of chloride and a neutral pH, which may offset the risk of hyperkalemia. The aim of this study is to determine the incidence of DGF in KTRs [...]

by Anna A. Pendina  , Mikhail I. Krapivin  , Irina D. Mekina  , Irina V. Aleksandrova  , Yanina M. Sagurova  , Evgeniia M. Komarova  , Mariia A. Ishchuk  , Andrei V. Tikhonov  , Olesya N. Bespalova  , Alexander M. Gzgzyan  , Igor Yu. Kogan  and Olga A. Efimova

Received: 13 May 2022;  Published: 23 September 2022;  doi: 10.21926/obm.genet.2203164

This paper suggests an approach for the use of a single paucicellular histological sample to investigate two characteristics indicative of the cell’s functional potential: 1) the content of telomerase reverse transcriptase (TERT) and 2) the telomere length. An algorithm has been suggested for the successive detection of the catalytic telomerase subunit with immunohistochemical staining and assessment of telomere length with Q-FISH on the same set of cells. The described approach uses three incontestable advantages [...]

by Loree Cook-Daniels

Received: 16 July 2023;  Published: 15 January 2024;  doi: 10.21926/obm.geriatr.2401266

Lesbian, gay, bisexual, transgender, and queer (LGBTQ+) elders are vulnerable to both the “usual” types of elder abuse (physical, sexual, emotional, and financial abuse, along with neglect), and with abuse that is specific to the context and history of LGBTQ+ elders. Training for adult protective services, long-term care ombudsmen, and other professionals who work with abused elders therefore should include information and skill-building in responding to this population. Research into effective training about LGBTQ [...]

by Hermann Moisl

Received: 28 August 2022;  Published: 01 February 2023;  doi: 10.21926/obm.neurobiol.2301152

Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account of the distance structure preservation that underlies the proposed mechanism of intrinsic intentionality. The three-layer autoassociative multilayer perceptron (aMLP) [...]

by Dennis Gibson  , Amy Stein  , Marina Foster  and Philip S Mehler

Received: 19 December 2024;  Published: 23 May 2025;  doi: 10.21926/rpn.2502012

Inpatient care is a significant contributor to the health-care costs associated with the treatment of individuals with eating disorders (EDs). This study seeks to better understand the treatment outcomes of individuals with extreme EDs requiring inpatient medical stabilization at specialized medical versus nonspecialized medical units. Patients transferred via air ambulance to ACUTE Center for Eating Disorders and Severe Malnutrition (specialized care) from an outside hospital (nonspecialized care) between January [...]

by Maria Gladysheva-Azgari  , Natalia Slobodova  , Eugenia Boulygina  , Svetlana Tsygankova  , Fedor Sharko  and Irina Mitrofanova

Received: 16 October 2023;  Published: 24 November 2023;  doi: 10.21926/obm.genet.2304203

In this study, we report the complete chloroplast genome of Actinidia arguta var. purpurea. The chloroplast genome is 157,369 bp long as the circular (GC ratio is 37.22%). It has four subregions: a large single-copy (LSC) region of 88,609 bp, a small single-copy (SSC) region of 20,470 bp, and two inverted repeat regions (IRs) of 24,145 bp in each. The chloroplast genome of A. arguta var. purpurea contains a total of 113 unique genes, which are 79 protein-coding genes, 4 rRNA genes, and 3 [...]