Applications of CRISPR-Cas9 Gene Editing Technology in Food Allergy Therapy: A Comprehensive Review
Abstract
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Applications of CRISPR-Cas9 Gene Editing Technology in Food Allergy Therapy: A Comprehensive ReviewAbstract
Worldwide, the incidence of allergenicity is rising rapidly, making it an ongoing clinical challenge and public health concern. The current treatment options for allergies include allergen avoidance, medications to improve symptoms, and immunotherapy to desensitize affected individuals to specific allergens. However, these approaches have limitations, and there is an urgent need for novel and more effective therapies. Allergies are a compelling candidate for gene editing (GE) given their prevalence and the inadequa [...] 51 265 |
Does Accepting a Wider Variety of Foods Mean Eating Better? The Food Paradox of Children and Adolescents with Feeding Difficultiesby
Abstract
This study descriptively investigates the food acceptance patterns and dietary profiles of neurotypical infants, children, and adolescents with Feeding Difficulties (FD) at a Brazilian pediatric reference center. It further examines whether a broader food repertoire translates into improved nutritional quality. The research, an observational, analytical cross-sectional study, analyzed data from 237 patients aged 10 to 204 months with FD. Findings revealed a discrepancy between family perceptions and professional as [...] 63 263 |
Assessing Land Use Dynamics and Thermal Stress in Ahmedabad Using Integrated Remote Sensing and Machine Learning TechniquesAbstract
The rapid urbanisation in developing countries has not only intensified land transformation but also significantly altered surface temperatures, thereby increasing climate vulnerability. Ahmedabad, one of India’s fastest-growing cities, has witnessed substantial urban growth over the past two decades and therefore requires an integrated approach to analyse land-use change, thermal dynamics, and future growth patterns. This study aims to analyse the spatial and temporal patterns of land use/land cover (LULC) changes [...] 74 254 |
Prenatal Diagnosis of Severe Factor VII Deficiency in the Setting of Maternal Breast CancerAbstract
Congenital factor VII (FVII) deficiency is the most common rare bleeding disorder (RBD), presenting with various clinical manifestations. Given the heightened risk of life-threatening bleeding and fatal hemorrhagic complications, prompt detection of the disorder is critical, especially in cases with low FVII levels and a history of familial severe clinical presentations. In such cases, prenatal diagnosis (PND) emerges as a life-saving option. In this study, we reported two PNDs in a family with a positive family hi [...] 88 245 |
A Compassionate Mind: A Qualitative Evaluation of Compassion Focused Group Therapy for Complex Interpersonal Traumaby
Abstract
A significant percentage of the population attending local adult psychology services have experienced variable forms of maltreatment from a young age and by a close attachment figure. For those who do not present with post-traumatic stress disorder symptoms, they may be misunderstood and offered a phase-based approach to their care. Although a stepped care approach to complex trauma is in keeping with current guidelines this often includes lengthy periods of group-based psychoeducation and skills development that o [...] 63 234 |
Psychosocial Death Education in Schools: Insights from Experienced PractitionersAbstract
Death Education is an emerging field aimed at developing psychological and social competencies for engaging with death and dying. This qualitative study explored the experiences of 17 professionals—including psychologists, teachers, and spiritual counselors—implementing Death Education interventions in schools. Semi-structured interviews were analyzed thematically, revealing four key domains: (1) facilitators’ personal relationship with death and motivation; (2) children’s and adolescents’ representations of death; [...] 52 188 |
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