OBM Transplantation (ISSN 2577-5820) is an international peer-reviewed Open Access journal published quarterly online by LIDSEN Publishing Inc., which covers all evidence-based scientific studies related to transplantation, including: transplantation procedures and the maintenance of transplanted tissues or organs; assimilation of grafted tissue and the reconstitution of removed organs or parts of organs; transplantation of heart, lung, kidney, liver, pancreatic islets and bone marrow, etc. Areas related to clinical and experimental transplantation are also of interest.
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New Challenges in Machine Perfusion in Organ Transplantation
Submission Deadline: December 15, 2023 (Open) Submit Now
Davide Ghinolfi, MD (Biography)
Division of Hepatic Surgery and Liver Transplantation, University of Pisa Medical School Hospital, Pisa, Italy
Research Interests: Proper selection of extended criteria grafts, DCD, the identification of markers of organ viability during normothermic regional and machine perfusion and organ therapeutics
About This Topic
In the last years, the field of organ transplantation has been revolutionized by the emergence and rapid adoption of machine perfusion technologies, such as normothermic regional perfusion, normothermic machine perfusion and hypothermic oxygenated machine perfusion. The use of the so-called “extended criteria” donors is largely adopted to improve the availability of donor allografts but these organs are more vulnerable to ischemia-reperfusion injury in comparison to standard grafts, hence carrying an increased risk of post-transplant dysfunction. Machines perfusion were introduced in clinical practice to minimize the duration of static cold storage, protect organs from the detrimental effects of ischemia-reperfusion injury, facilitate repair/regeneration of extended criteria donor grafts, expand donor pool, and improve graft survival after transplant. Nevertheless, machine perfusion have the potential to become the new standard for organ procurement and preservation only if the risen costs, logistic complexity and extra time and personnel requirements are objectively justified by increased available grafts or decreased post-transplant complications. The transition of these technologies into clinical practice does not mark the end of a development process but, rather, the start of the clinical evolution of these devices and their applications. Fulfilling the true potential of these technologies can only be realized by appreciating their existing limitations and identifying new boundaries to push (1).
(1) Ghinolfi, D. 2022. MACHINE PERFUSION IN ORGAN TRANSPLANTATION. European Journal of Transplantation. 1, (Oct. 2022), 2–3. DOI:https://doi.org/10.57603/EJT-002.
Machine perfusion technologies;
Normothermic regional perfusion;
Normothermic machine perfusion;
Hypothermic oxygenated machine perfusion;
Extended criteria donor grafts;
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