by Filomena Emanuela Laddaga  , Tommasina Perrone  , Pellegrino Musto  , Ilaria Farella  , Stefano Martinotti  and Francesco Gaudio

Received: 22 February 2025;  Published: 18 June 2025;  doi: 10.21926/obm.transplant.2502253

Primary mediastinal large B-cell lymphoma (PMLBCL) is an aggressive B-cell malignancy that may exhibit resistance to standard chemoimmunotherapy. Novel immunotherapeutic strategies, including checkpoint inhibitors and chimeric antigen receptor T-cell (CAR-T) therapy, are being explored in cases that are refractory to treatment. We report the case of a 29-year-old patient with refractory PMLBCL who was treated with pembrolizumab as a bridging therapy followed by axicabtagene ciloleucel (CAR-T) after failing R-CHOP a [...]

by Manish Suryapalam  , Jay Kanaparthi  , Shineui Kim  , Pedram Shafiei-Jahani  , Armeen Barghi  and Mohammed Kashem

Received: 10 November 2024;  Published: 11 June 2025;  doi: 10.21926/obm.transplant.2502252

While heart transplantation is increasingly performed in the United States for elderly patients, survival outcomes have primarily been analyzed in single-center studies. The few existing long-term studies have indicated no difference in HTx outcomes between patients ≥70 years and 60-69 years age, but these studies only assessed to 5-years post-transplant and included data from the 1980-90s, introducing significant variance due to poorer outcomes in that era. We analyzed the UNOS database from 1987-2020, stratified [...]

by Elham Amjad  and Babak Sokouti

Received: 21 February 2025;  Published: 09 June 2025;  doi: 10.21926/obm.transplant.2502251

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as liver biopsies and liver function tests (LFTs), often fail to identify abnormalities early and with accuracy. Genomic RNA sequencing (RNA-Seq) has recently emerged as a powerful approach for identifying molecular markers o [...]

by Filomena Emanuela Laddaga  , Bruna Daraia  , Pamela Pinto  , Antonio D’amato  , Stella D’oronzo  , Stefano Martinotti  and Francesco Gaudio

Received: 23 January 2025;  Published: 06 June 2025;  doi: 10.21926/obm.transplant.2502250

Off-the-shelf cellular therapies, utilizing allogeneic T cells derived from healthy donors, represent a promising alternative to autologous chimeric antigen receptor T-cell (CAR-T) therapies for the treatment of hematological malignancies such as leukemias and lymphomas. Unlike autologous approaches, which require the patient’s own cell collection, modification, and expansion, off-the-shelf therapies can be prepared in advance, substantially reducing treatment timelines, decreasing costs, and improving global acces [...]

by Moussa Hamidani  , Salah Aberkane  and Moudjahid Aissaoui

Received: 17 December 2024;  Published: 16 May 2025;  doi: 10.21926/obm.transplant.2502249

Although immunosuppressive drugs are essential and effective in improving the health status of renal transplant patients, they also make them more vulnerable to the risk of infection with COVID-19, which has become a significant concern for many patients. Perhaps this is what makes their way of thinking and perception impact their adherence to taking immunosuppressants. Therefore, this study reveals the possibility of an impact of illness perception and some sociodemographic and clinical factors on treatment adhere [...]

by Camilo A. Velasquez  , Simon Yaguare  , Sabrina Gambini  , Elizabeth McElhiney  and Suresh Keshavamurthy

Received: 19 September 2024;  Published: 27 April 2025;  doi: 10.21926/obm.transplant.2502248

Lung transplantation (LTx) is the gold standard for the surgical treatment of end-stage lung disease. Ongoing discussions persist whether single lung transplantation (SLT) or bilateral lung transplantation (BLT) lead to better patient outcomes and quality of life. This study analyzed 58 peer-reviewed articles from 1990 to 2024, comparing SLT and BLT across several parameters, including indications for transplantation, overall survival, pulmonary hypertension, complications, chronic rejection, functional status, and [...]

by Michael J Eiswerth  and Joel Wedd

Received: 30 November 2024;  Published: 17 April 2025;  doi: 10.21926/obm.transplant.2502247

The prevalence of alcohol use disorder (AUD) and alcohol-related liver disease (ALD) has increased in the last two decades. ALD is currently the most common indication for both waitlist additions and liver transplant (LT) in the United States, including alcohol-associated cirrhosis, alcohol-associated hepatitis (AH), and acute-on-chronic liver failure (ACLF). ALD also has a significant global disease burden. LT in ALD is a complex paradigm that poses both medical and ethical challenges, requiring a multidisciplinar [...]

by Sara Evans  , Ariba Moin  and Ashwini Arjuna

Received: 13 June 2024;  Published: 09 April 2025;  doi: 10.21926/obm.transplant.2502246

Varicella-zoster virus (VZV) significantly impacts the central and peripheral nervous systems, particularly in immunocompromised individuals. This case report details a rare presentation of VZV meningoencephalitis in a 42-year-old woman with interstitial lung disease and connective tissue disease undergoing lung transplant evaluation who presented with a thunderclap headache and a new-onset seizure. Despite normal initial MRI findings, further investigation with PCR of the cerebrospinal fluid (CSF) revealed the pre [...]

by Ramin Raoufinia  , Saleh Hashemi  , Kimia Arabi  , Karim Naghipoor  , Farhad Fakoor  and Ehsan Saburi

Received: 20 October 2024;  Published: 02 April 2025;  doi: 10.21926/obm.transplant.2502245

In orthopedics and oncology, benign and malignant bone lesions pose significant clinical challenges. Malignant tumors, like osteosarcomas and multiple myeloma, pose substantial health dangers and can spread common and mostly non-life-threatening benign lesions, including non-sizing fibromas and unicameral bone cysts. Treatment plans for bone lesions may involve radiation, chemotherapy, and surgical excision, depending on their type. Combining stem cell research, bioactive materials, and advanced scaffold design, cu [...]

by Ibrahim Nahit Sendur  , Büsra Köksoy  and Yasemin H. Balaban

Received: 11 November 2024;  Published: 01 April 2025;  doi: 10.21926/obm.transplant.2502244

Cytomegalovirus (CMV) remains a significant cause of morbidity and mortality in solid organ transplant (SOT) recipients. Despite advancements in prophylaxis and antiviral therapy, CMV continues to pose clinical challenges in transplant medicine. This review provides a comprehensive overview of CMV, exploring its pathophysiology, epidemiology, and clinical presentation in SOT patients, in whom CMV infection can lead to direct organ involvement and systemic symptoms. Additionally, CMV has indirect effects, including [...]