Table of Content

Open Access Case Report

An Unusual Case of Recurrent Capillary Leak Syndrome Following Lung Transplantation

Brian C. Keller, Sadia Z. Shah, Amy Pope-Harman
Received: April 24, 2020; Published: June 15, 2020; doi:10.21926/obm.transplant.2002113

Abstract: Systemic capillary leak syndrome is a disorder characterized by recurrent, life-threatening episodes of acute capillary hyperpermeability resulting in edema and hypovolemic shock. We report a case of systemic capillary leak syndrome in a lung transplant recipient who developed recurrent episodes of [...]

16 146

Open Access Review

Birth Tissue-Derived Mesenchymal Stromal/Stem Cell Isolation and Assessment

Robert B. Diller, Robert G. Audet, Mediha Gurel, Eric T. Lee, Aaron J. Tabor, Peter McFetridge, Robert S. Kellar
Received: September 25, 2019; Published: June 09, 2020; doi:10.21926/obm.transplant.2002112

Abstract: Mesenchymal Stromal/Stem Cells (MSCs) were originally discovered in the 1970s. MSCs are considered a multipotent population that retain tri-lineage differentiation. These cells can be sourced from a variety of tissues, including bone marrow, adipose, molar pulp, and birth tissues. Historically varyi [...]

15 171

Open Access Editorial

Liver Transplantation in Pediatrics

Yasuhiko Sugawara
Received: May 15, 2020; Published: May 18, 2020; doi:10.21926/obm.transplant.2002111

21 212

Open Access Review

Multidrug-Resistant Bacterial Infections before and after Liver Transplantation

Alberto Ferrarese, Marco Senzolo, Patrizia Burra
Received: March 29, 2020; Published: May 18, 2020; doi:10.21926/obm.transplant.2002110

Abstract: Bacterial infection represents a common event in the natural history of cirrhosis, especially in patients with end-stage liver disease. An episode of bacterial infection may significantly modify a patient’s outcome in the setting of liver transplantation (LT) by impairing hepatic and extrahepatic or [...]

26 223

Open Access Original Research

Donor Age and Ischemia Time Are Independent Factors Affecting Graft Survival after En Bloc Kidney Transplantation from Donors Less than Three Years of Age

Antoine Buemi, Jérôme Duisit, Flora Musuamba, Tom Darius, Martine De Meyer, Selda Aydin, Nada Kanaan, Arnaud Devresse, Eric Goffin, Michel Mourad
Received: January 13, 2020; Published: May 13, 2020; doi:10.21926/obm.transplant.2002109

Abstract: This study aimed to investigate the outcomes of transplantation from donors aged less than three years in a single-center consecutive series. A total of 52 en bloc kidney graft transplantations were performed. In 22 cases, organs were procured from donors aged less than one year (group 1). In 30 cas [...]

23 243

Open Access Review

Clinical Approach to the Management of Infections before and after Liver Transplantation

Anita Verma, Anil Dhawan
Received: February 14, 2020; Published: May 11, 2020; doi:10.21926/obm.transplant.2002108

Abstract: The infectious complications before and after liver transplant (LT) are affected by the severity of liver disease and immunosuppression intensity after transplantation. Both cirrhosis and immunosuppression contribute to dysfunction of defensive mechanisms of the host. When a patient is evaluated for [...]

17 231

Open Access Review

Genomic Biomarker Surveillance in the Care of Solid Organ Transplant Recipients: An Update for the General Clinician during the Coronavirus (CoVid-19) Pandemic

Allison Ramsey, Christine Natori, Kristen Cisneros, David J. Ross, Abbas Ardehali
Received: March 27, 2020; Published: May 06, 2020; doi:10.21926/obm.transplant.2002107

Abstract: Biomarker surveillance after solid organ transplant is an advancing field with promise for further elucidation through high-throughput analyses and “omics” technologies. To date, Gene Expression Profiling (GEP; AlloMapâ) is the only FDA-cleared genomic assay as surveillance for moderate-severe TCMR [...]

90 228

Open Access Editorial

Challenges to Transplantation by the Assault of CoVid-19: Emergence of Molecular Diagnostics as Surveillance

David J. Ross
Received: March 27, 2020; Published: March 31, 2020; doi:10.21926/obm.transplant.2001106

57 526

Open Access Case Report

Pediatric Mixed Left Ventricular Non-Compaction and Restrictive Cardiomyopathy Bridged to Heart Transplant with Ventricular Assist

Adam K. Morrison, Robert J. Gajarski, Ashley Hodge, Sara Fitzgerald-Butt, Peter Baker, Patrick M. McConnell, Deipanjan Nandi
Received: May 21, 2019; Published: March 26, 2020; doi:10.21926/obm.transplant.2001105

Abstract: Left ventricular noncompaction cardiomyopathy (LVNC) is a rare form of heritable cardiomyopathy with wide genotypic variability, numerous phenotypic variations, and a wide spectrum of clinical disease from asymptomatic to end stage heart failure. Here, we present a case of a 2-year-old b [...]

32 272

Open Access Review

Medawar's Paradox and Immune Mechanisms of Fetomaternal Tolerance

Victoria Rendell, Natalie M. Bath, Todd V. Brennan
Received: May 09, 2019; Published: March 10, 2020; doi:10.21926/obm.transplant.2001104

Abstract: Brazilian-born British biologist Dr. Peter Medawar played an integral role in developing the concepts of immunologic rejection and tolerance, which led to him receiving the Nobel Prize “for the discovery of acquired immunologic tolerance” and eventually made organ transplantation a reality. However, [...]

46 454