by Yi-nan Guo  , Michael Grzelak  and Byoung Chol Oh

Received: 10 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.transplant.1804031

One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive therapies must be the development of a low-side effect therapy. Cell-based therapies as an emerging candidate offer a novel approach to generating graft tolerance, and when utilized within a combination therapeutic strategy, [...]

by Stephan John  , Svenja Rink  , Leandra Weidemann  , Katrin Huesker  and Wilhelm Niedermeier

Received: 21 April 2022;  Published: 15 June 2022;  doi: 10.21926/rpm.2202012

Combining dental ceramics with other prosthetic metallic restorations might release metal ions, thus affecting the oral tissues of the patients. In this study, we evaluated the electrochemical solubility of various dental ceramics in a galvanic experimental setup in vitro. Smooth and rough feldspathic and zirconium dioxide ceramics (at pH 5.5 and pH 3.0) were exposed to an electric field. Calcium, barium, and zirconium were selected as parameters to determine the solubility of both types of ceramic materials. Among [...]

by Jessica Ferguson  , Marisa Holubar  , Waldo Concepcion  and Dora Y. Ho

Received: 24 July 2020;  Published: 09 November 2020;  doi: 10.21926/obm.transplant.2004122

Liver transplant recipients (LTRs) are at risk for vancomycin-resistant Enterococcus (VRE) infections which can lead to significant morbidity or mortality. Antibiotic exposure, including vancomycin, is associated with greater risk of VRE infection. This study aimed to assess the appropriateness of vancomycin use and rates of VRE infection in this population. We performed a retrospective cohort study of 327 patients who underwent liver transplantation at our center from January 1, 2012 to June 30, 2017. Sixty (18.3% [...]

by Suman Roy

Received: 27 September 2022;  Published: 03 January 2023;  doi: 10.21926/rpm.2301001

Increased occurrence of dynamic loading on bridge piers caused by seismic, blast and vehicular impact incidences have been increasingly reported. Statistical data shows that while seismic and blast have received significant attention in the literature despite the frequency of occurrence of vehicular impact is remarkably higher. Unfortunately, pier damage caused by high velocity vehicle impact contemplates a little consideration. With the newer construction methods like accelerated bridge construction (ABC) and its [...]

by Sally Rose  and David Sheffield

Received: 05 August 2022;  Published: 22 December 2022;  doi: 10.21926/obm.icm.2204055

This article examines the practice of combining explorations of regulated and dysregulated states through the Workable Ranges Model (WRM) with the skills and qualities taught in Mindfulness-Based Stress Reduction (MBSR). MBSR was designed to help participants to self-regulate stress. Didactic teaching about stress reactivity is part of the curriculum and may contribute to positive outcomes. A practice-based embodied methodology utilised mindful inquiry in research methods. Seven graduates of MBSR courses that inclu [...]

by Vincenza Rita Lo Vasco

Received: 27 January 2023;  Published: 05 May 2023;  doi: 10.21926/obm.geriatr.2302234

Illnesses following the degeneration of the nervous system can occur due to aging or genetic mutations and represent a clinical concern. In neurodegenerative diseases, loss of neuronal structure and functions mainly causes cognitive impairment, representing an increasing social burden. In neurodegenerative diseases, the progressive loss of vulnerable populations of neurons in specific regions of the central nervous system was traced to different pathological events, such as misfolded proteins’ accumulation, abnorma [...]

by Dennis Gibson  , Amy Stein  , Marina Foster  and Philip S Mehler

Received: 19 December 2024;  Published: 23 May 2025;  doi: 10.21926/rpn.2502012

Inpatient care is a significant contributor to the health-care costs associated with the treatment of individuals with eating disorders (EDs). This study seeks to better understand the treatment outcomes of individuals with extreme EDs requiring inpatient medical stabilization at specialized medical versus nonspecialized medical units. Patients transferred via air ambulance to ACUTE Center for Eating Disorders and Severe Malnutrition (specialized care) from an outside hospital (nonspecialized care) between January [...]

by Karine Dornela Rosa  , Tara Rava Zolnikov  , Rodrigo Souza Leite  , Sérgio Caldas  , Job Alves de Souza Filho  , Raquel Sampaio Jacob  and Marcos Paulo Gomes Mol

Received: 05 May 2022;  Published: 11 July 2022;  doi: 10.21926/aeer.2203028

Visceral leishmaniasis (VL) is a vector-borne disease that is caused by the protozoan Leishmania infantum and transmitted to humans and other mammals through the bites of infected female sandflies. VL has been prevalent in Minas Gerais, Brazil, since the 1940s. As the vector completes its reproductive cycle in the soil with organic matter, the association between the occurrence of VL and unimproved solid waste disposal sites has been investigated. Thus, in this study, we analyzed the relationship of waste disposal [...]

by Shalika B. Katugaha  , Amit K. Mahajan  , Meg Fregoso  , Haresh Mani  and Oksana A. Shlobin

Received: 25 October 2020;  Published: 03 July 2021;  doi: 10.21926/obm.transplant.2103147

A 65-year-old female with a history of right lung transplantation (LTx) for chronic obstructive pulmonary disease (COPD) 9-years prior complicated by grade 3 bronchiolitis obliterans syndrome (BOS) was admitted to the hospital for chest pain and dyspnea on exertion (DOE). Her bronchoscopy revealed fluffy, endobronchial lesions that were adherent to the right sided anastomosis resulting in mild obstruction of the right mainstem bronchus. Pathology from biopsies of the endobronchial lesions revealed hyphal fungal org [...]

by Damiana Scuteri  , Paolo Tonin  , Maria Tiziana Corasaniti  and Giacinto Bagetta

Received: 05 July 2022;  Published: 14 September 2022;  doi: 10.21926/obm.neurobiol.2203133

Alzheimer’s disease (AD) accounts for 50–70% of cases of dementia worldwide and is a social burden to the affected population. Although several pathogenetic hypotheses have been proposed, evidence favoring the role of aberrant neuroplasticity in the development of the neuropsychiatric symptoms associated with dementia is increasing. Specifically, agitation is resistant to treatment and affects the quality of life, also because of the lack of safe and effective treatment for AD. Alterations in pain processing due to [...]

by Cynthia M.A. Geppert  and Ronald W. Pies

Received: 01 March 2019;  Published: 04 March 2019;  doi: 10.21926/obm.icm.1901016

Compassion in Clinical Care

by Amer Belal  , Shawna Lord  , Rohan V. Mehta  and Alfonso Santos

Received: 28 October 2022;  Published: 19 April 2023;  doi: 10.21926/obm.transplant.2302182

Cryptococcosis is a common invasive fungal infection in solid organ transplant recipients (SOTR) that can be challenging to manage. We discuss a case of disseminated cryptococcosis in a transplant recipient. A 26-year-old woman with a history of ESRD from C1q nephropathy, living-related kidney transplant in early 2012, and allograft nephrectomy in 2015, received a deceased donor kidney transplant (DDKT). Induction after the first transplant was anti-thymocyte globulin (ATG) and maintenance immunosuppression (IS) in [...]

by Ines Testoni  , Lorenza Palazzo  , Sara Pompele  , Ciro De Vincenzo  , Maria Perardi  and Lucia Ronconi

Received: 13 November 2022;  Published: 31 March 2023;  doi: 10.21926/obm.neurobiol.2301165

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disease that affects motor neurons, the nerve cells in the brain and the spinal cord that enable voluntary muscle movement. Managing ALS is complex and increasingly requires informal care, most often by the patient's companions/spouses or children. The COVID-19 pandemic posed additional critical issues, particularly the disruption of home care and the increased time caregivers spent on patient care. One aim of this research was to assess caregiv [...]

by Abdel Zaro  , Spencer Jones  and Ethan Languri

Received: 31 August 2023;  Published: 16 November 2023;  doi: 10.21926/jept.2304035

In this paper, an efficient industrial wastewater and leachate evaporation method is proposed and tested experimentally. The goal of this study is to investigate whether the addition of a carbon foam (CF) porous layer can lead to energy savings by evaporating more water mass per unit of energy input. The standard boiling evaporator layout was redesigned by placing the heating element in the upper region of the tank and CF underneath the heat source. The CF purposed to localize the energy in an area by the water' [...]

by Ousman Bajinka  , Mamtuti Panneh  , Sang Mendy  , Amadou Barrow  , Haddy Bah  , Lamarana Jallow  , Jarry Jallow  , Kaddy Drammeh  , Kaddijatou Kah  , Oulimatou Lateef  , Mariama A Bah  , Isatou K Sillah  , Fatoumata Bah  , Nyima Ceesay  , Mariama Jaiteh  and Yurong Tan

Received: 31 August 2024;  Published: 08 April 2025;  doi: 10.21926/rpn.2502006

The adverse effects of maternal passive smoking during pregnancy on offspring health remain understudied in sub-Saharan Africa, particularly in The Gambia, where smoke-free regulations are limited. To determine the prevalence of maternal passive smoking (MPS) during pregnancy and investigate its associations with adverse pregnancy outcomes and offspring health complications in The Gambia. A cross-sectional study was conducted in February 2023 among 401 mothers with children under 5 years in urban and rural regions [...]

by A. Guillermo Bracamonte

Received: 28 July 2023;  Published: 15 November 2023;  doi: 10.21926/rpm.2304034

This mini-review discussed the best-known chemical and synthetic methodologies used in the last years to modify carbon allotropes, with an interest in nanotechnology. In this perspective, chemistry with optoelectronics applications and recent trends within bio-applications focusing mainly on graphene and its derivatives were considered. So, the mini-review intended to focus on methodologies to add functional groups with varied reactivities, polymer chemistry, and nanoscale control. These methodologies provide insig [...]

by Livinus Emebiri

Received: 18 August 2023;  Published: 24 November 2023;  doi: 10.21926/rpn.2304023

Wheat (Triticum aestivum L.) is pivotal to global food security, with its energy-rich grains that are also the major vegetable protein source in human diets. Decades of primary emphasis on grain yield improvement have delivered increased gains worldwide, but the grain protein content has declined. Since amino acids are biosynthetic precursors of proteins, this research hypothesized that their contents in the wholegrain flour have also been impacted by past wheat breeding. To test this, the free amino acid content o [...]

by Hannah Lewandowski  , Lindsay Crawford  and Paul D. Loprinzi

Received: 13 April 2019;  Published: 25 June 2019;  doi: 10.21926/obm.icm.1902039

Acute exercise may enhance episodic memory recall, or the retrospective recall of an event or episode due to exercise-induced neuronal excitability and ensuing long-term potentiation. Of interest to this paper is the potential effects of acute exercise on memory interference, when the interfering stimuli occurs at the same time as the target stimuli. A three-arm, parallel-group randomized controlled intervention was employed. Participants (N=50) were randomized into one of three groups, including 1) Interference + [...]

by Michael Hales  and Robert Marx

Received: 10 January 2022;  Published: 19 April 2022;  doi: 10.21926/obm.icm.2202019

Service-user volunteers in a National Health Service (NHS) Mental Health Trust in the UK have made an unusual contribution to mindfulness teaching, training, research and governance as ‘advocates’ of mindfulness-based therapy interventions. We explore the nature of what has been named internally as the ‘wisdom’ of the ‘advocate’ group in this NHS Trust, and its impact on mental health provision. A clinician (clinical psychologist) and an advocate (anthropologist) conduct an investigative conversational journey usin [...]

by Simona Ruggirello  , Enrica L. Santarcangelo  and Laura Sebastiani

Received: 10 September 2019;  Published: 18 December 2019;  doi: 10.21926/obm.icm.1904066

Background: Hypnotizability is a psychophysiological trait associated with several differences including the level of functional equivalence (FE) between imagery and perception, i.e., the similarity of the cortical activations and network configurations associated with each of them. FE is stronger in high hypnotizability individuals (highs) than low hypnotizable participants (lows). In this framework, this study investigates the correlation between electroencephalogram (EEG) of imagined arm/hand movements (MI) and [...]

by Bhagyashree Deshmankar  , Craig E. Eckfeldt  , Graf Oliver  , Aleksandr Lazaryan  and Nelli Bejanyan

Received: 19 July 2020;  Published: 18 September 2020;  doi: 10.21926/obm.transplant.2003118

Severe hypercholesterolemia is an uncommon complication of allogenic hematopoietic cell transplantation (HCT). Treatment options for hypercholesterolemia due to liver graft-versus-host disease (GVHD) are limited because many antilipidemic medications are known to worsen hepatic functions. We report our experience on a case of a 38-year-old male with Philadelphia chromosome positive acute lymphoblastic leukemia presenting with steroid-refractory hepatic and lower gastrointestinal acute GVHD after matched sibling don [...]

by Giacinto Libertini

Received: 22 July 2022;  Published: 14 October 2022;  doi: 10.21926/obm.geriatr.2204208

The interpretation of aging as an adaptive and programmed phenomenon implies the existence of specific genetically determined and regulated aging-causing mechanisms. This interpretation is in contrast to the explanation of aging as the gradual accumulation of the effects of harmful factors that are only partially countered by natural selection. The subtelomere–telomere theory of aging offers what is required by the interpretation of aging as a programmed phenomenon. The experimentally documented mechanisms that are [...]

by Nadia A. Abdelmegeed Abdelwahed  and Muhammad Sufyan Ramish

Received: 18 December 2024;  Published: 26 May 2025;  doi: 10.21926/obm.neurobiol.2502288

The present study investigates the association between anger, stress, psychological distress and mood disorders among Egyptian entrepreneurs. Approach-wise, the study is quantitative, and its cross-sectional data were collected using a questionnaire. The study’s respondents are Egyptian entrepreneurs involved in several business activities. Hence, the study concluded based on 286 valid responses. We used analysis of moment structures (AMOS) software, where we conducted path analysis to conclude the results. C [...]

by David Bayo  , Olufunso Adeniyi  , Adebayo Adeniyi  and Oluwole Ariwoola

Received: 27 February 2021;  Published: 12 May 2021;  doi: 10.21926/acr.2102013

The present study investigated the level of heavy metals in selected fruits sold commonly in Jos, Nigeria. The fresh fruits (Avocado pear, Black currant, Egg Plant, Golden melon, and Soursop) were purchased from five major markets (Terminus, Farin Gada, Building materials, Bukuru, and Fobur) in Jos. Each fruit sample was collected in triplicate and analyzed using standard procedures. The concentration of heavy metals (Fe, Cu, As, Cd, Zn, Pb, Mn, and Cr) was determined using Graphite Furnace Atomic Absorption Spectr [...]

by Joana Sousa

Received: 10 March 2022;  Published: 24 August 2022;  doi: 10.21926/rpm.2203015

Exposure to indoor pollutants may exert a significant effect on children health as they spend most of their time in enclosed environments. This research compared the association of biological concentrations with indoor characteristics and building materials in places where children spend significant time indoors. It was compared the results of two autonomous research projects conducted in Porto primary schools and households. Both the projects included a walkthrough inspection and biological measurements in indoor [...]