by Manon Dethoor  , François Vialatte  , Marion Martinelli  , Pauline Peri  , Christophe Lançon  and Marion Trousselard

Received: 23 August 2022;  Published: 28 December 2022;  doi: 10.21926/obm.icm.2204058

While there is abundant literature on the benefits of Mindfulness-Based Interventions (MBI), data about factors associated with their Efficiency are scarce. Our study attempts to determine the moderators of efficacy and adherence in Mindfulness-Based Cognitive Therapy (MBCT) with a machine learning analysis. Seventy-six psychiatric outpatients at “university hospital mental health service” had a prescription for MBCT from their referring psychiatrist. They suffer from various psychiatric illnesses with [...]

by Ajay Risal  , Dipak Kunwar  and Barsha Shrestha

Received: 21 December 2023;  Published: 08 February 2024;  doi: 10.21926/obm.geriatr.2401268

This paper discusses the impact of Depression on the aging population. It also tries to explore the psychosocial risk factors and burden associated with geriatric depression in low-and-middle-income (LAMI) countries. Nepal, a South Asian developing country, is resource-poor and research-naïve. Research, in general, and mental health studies, in particular, are the least prioritized in this country. The lack of culturally adapted psychiatric inventories is one of the possible reasons for the low number of mental hea [...]

by Pål-Dag Line

Received: 20 December 2017;  Published: 24 December 2017;  doi: 10.21926/obm.transplant.1704006

by Giuseppe Cocco  and Stefano Pandolfi

Received: 07 February 2022;  Published: 16 June 2022;  doi: 10.21926/obm.geriatr.2202200

Syncope is characterized by a transient and rapid loss of consciousness for a short duration, with full spontaneous recovery within minutes. Syncope causes up to 2% of all emergency medical consultations. The incidence of syncope is similar in men and women, is higher in old patients (slightly higher in old women). The prevalence of syncope is up to 23% for the institutionalized elderly. In elderly patients, syncope often presents atypically, such as with falls; these patients might also have difficulty recalling e [...]

by Sylvaine You  and Lucienne Chatenoud

Received: 25 September 2018;  Published: 09 November 2018;  doi: 10.21926/obm.transplant.1804025

Transplant tolerance has been achieved in experimental models using immune intervention strategies. Yet, their clinical translation remains unsuccessful and requires further optimization of immunotherapeutic regimens based on a deeper understanding of the cellular and molecular mechanisms at play in the induction and maintenance phases of immune tolerance. Intensive investigations have shed light on the tolerogenic networks underlying graft survival and have unraveled their complexity, which may depend on several p [...]

by Kazuki Mochizuki  , Ayumi Osaki  , Yuko Inamochi  and Toshinao Goda

Received: 18 December 2017;  Published: 30 October 2018;  doi: 10.21926/obm.genet.1804046

Background: Histone modifications, including acetylation and H3 lysine 4 (K4) methylation, are thought to be associated with transcriptional activation during differentiation. Methods: mRNA and histone modifications around the sucrase-isomaltase (SI) gene in Caco-2 cells (a small intestine cell line) during differentiation were determined by qRT-PCR and chromatin immunoprecipitation, respectively. Results: Mono-, di-, and tri-methylation of histone H3K4 on the SI gene correlated with the induction of SI gene expres [...]

by Kamal Kant Sahu

Received: 01 November 2020;  Published: 19 November 2020;  doi: 10.21926/obm.transplant.2004126

by Dicky Moch Rizal  , Ika Setyawati  , Arya Adiningrat  , Agus Widiyatmoko  , Supriyatiningsih  and Nandia Septiyorini

Received: 09 October 2023;  Published: 27 February 2024;  doi: 10.21926/obm.genet.2401216

Y chromosome microdeletions (YCMs) are one kind of genetic disorder that contributes to male infertility. This study aims to determine the profile of YCMs in the infertile male population in Indonesia. This cross-sectional study was conducted by identifying YCMs testing data on 49 infertile male patients identified with azoospermia and oligoasthenoteratozoospermia (OAT) based on their sperm analysis, who visited andrology polyclinics in several hospitals in Yogyakarta Province between March 2021 to August 2022. Stu [...]

by Katherine W. Zerebiec  , Magalie Carey  , Noah Kolb  , Tracy Lamoy  , Divyanshu Dubey  and Michael K. Hehir

Received: 15 November 2022;  Published: 08 May 2023;  doi: 10.21926/obm.neurobiol.2302168

A 46-year-old, previously healthy woman presented via telemedicine with 14 months of progressive asymmetrical weakness, numbness, paresthesias and tremors. History and clinical exam findings suggested a peripheral etiology resembling a variant CIDP presentation. Electrodiagnostic testing identified only one motor nerve with signs of demyelination; the remainder of motor and sensory nerves were unable to be evoked. MRI showed diffuse enhancement of the trigeminal nerve and cauda equina. CSF revealed albuminocytologi [...]

by Kanto Araki  , Keita Kiuchi  and Katsumasa Kishi

Received: 28 December 2020;  Published: 12 March 2021;  doi: 10.21926/obm.icm.2101008

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak is expected to have harmed the mental health of numerous people worldwide. Therefore, the present study was aimed to explore the effects of the SARS-CoV-2 outbreak on the overall health of the general Japanese population, with a particular focus on identifying the factors associated with a requirement for mental health treatment. Japanese residents aged 18 years and above were surveyed online, and among the 1,500 obtained responses included for a [...]

by Rachel Hull  , Scott Browning  and Melanie Puzio

Received: 11 April 2022;  Published: 25 July 2022;  doi: 10.21926/obm.icm.2203029

The authors attempted to operationalize the clinical work of strategic theorist and expert family therapist, Scott Browning. Strategic therapy takes the position that a client is stuck, not necessarily sick. This focus encourages the clinician to create alternative perspectives such that a client learns to consider a problem from a new lens. Milton Erickson, a progenitor of strategic thinking, used hypnosis and paradox to nudge clients toward a useful alternative perspective [1]. The present article examined three [...]

by Yulia Aleksandrova  , Alexey Semakov  , Dmitry Tsypyshev  , Kirill Chaprov  , Sergey Klochkov  and Margarita Neganova

Received: 23 August 2023;  Published: 09 January 2024;  doi: 10.21926/obm.neurobiol.2401207

Here, we report the results of an investigation of the neuroprotective effects of securinine with tryptamine conjugate-allomargaritarine (2b), previously selected as the leading compound among a wide range of natural derivatives. 2b was synthesized from securinine using various Lewis acids as catalysts. In addition to the antioxidant and cytoprotective properties previously shown for 2b, in this work, in vitro analysis of the biological activity of the compound demonstrated that this conjugate is also able to influ [...]

by Nicolas A. Ishiki  , Maria L. Della-Costa  , Beatriz Keller  , Kleper O. Rocha  , Francielle Bortoloti  and Antonio C. D. Ângelo

Received: 04 September 2023;  Published: 16 November 2023;  doi: 10.21926/cr.2304027

This paper investigates how the aggregation of bimetallic nanoparticles (NPs) influences the electronic condition of the surface adsorption site and, hence, the performance of materials during the electrooxidation of fuels in an alkaline medium. First, we synthesized Pt-Ni NPs in three configurations: ordered intermetallic, ordinary alloy, and core-shell. The NPs contained Pt and Ni close to a 1:1 Pt/Ni atomic ratio. They had similar particle sizes, which allowed us to evaluate their performance without the influen [...]

by Yasuhiro Kotera  , Jenai Lieu  , Hou Tin Gillian Liu  , Christian Veasey  and Kristian Barnes

Received: 09 January 2024;  Published: 27 June 2024;  doi: 10.21926/obm.icm.2402036

Yozan Uesugi was a Daimyo (feudal lord) who governed an area called Yonezawa in Yamagata Prefecture, Japan from 1767 to 1823. Yonezawa was originally an impoverished provincial government which under his leadership regained a healthy financial status. His leadership style was unique among Daimyos, yet respected and regarded as an ideal by many including President John F. Kennedy. One of the characteristics of Yozan’s leadership was he demonstrated what he expected his people to do, instead of just telling them what [...]

by Yi-nan Guo  , Michael Grzelak  and Byoung Chol Oh

Received: 10 October 2018;  Published: 13 December 2018;  doi: 10.21926/obm.transplant.1804031

One of the major hurdles still facing the field of transplantation is the management of immunosuppression and the morbidity that results from treatment. Due to toxicity and complications from a maintenance immunosuppression therapies, a necessary improvement in post-transplant immunosuppressive therapies must be the development of a low-side effect therapy. Cell-based therapies as an emerging candidate offer a novel approach to generating graft tolerance, and when utilized within a combination therapeutic strategy, [...]

by Michel Boukar  , Etienne Tchoffo Houdji  , Dimitri Valdes Tchuindjang Kwatchie  , Guy Bertrand Tchaya  and Danwe Raidandi

Received: 25 March 2024;  Published: 01 August 2024;  doi: 10.21926/jept.2403014

Many sensible heat storage materials are regularly used as thermal energy storage (TES) systems to improve the efficiency of solar dryers. The present work focuses on the effects of the volume and particle sizes of a volcanic stone (pozzolan) for the same purpose. Samples soaked in matt black and without soaking were also considered. Heat charge and discharge tests were carried out by exposing the pozzolan contained in a solar collector of the direct solar dryer (DSD) and indirect solar dryer (ISD) to the sun. Char [...]

by Gloria Gutman  , Mojgan Karbakhsh  and Heather Stewart

Received: 20 December 2023;  Published: 16 April 2024;  doi: 10.21926/obm.geriatr.2402278

Lesbian, gay, and bisexual (LGB) older adults may be more vulnerable to elder abuse (EA) due to prior marginalization and trauma, lifelong discrimination, and health disparities. While characteristics of both victims and perpetrators can modify the risk for EA, few studies have focused on perpetrators. This study examined the number and type of perpetrator-victim relationships and perpetrator profiles for EA experienced in the prior year, by abuse type and sexual orientation and gender identity of the abused. Data [...]

by Sadeq Hamood Saleh Azzam  , Amreen Khanum  and Mohamed Afzal Pasha

Received: 30 September 2022;  Published: 15 February 2023;  doi: 10.21926/cr.2301007

2-Phenyl-4-arylmethylidene-5-oxazolinones were synthesized in very high yield by subjecting a mixture of an aryl aldehyde/heterocyclic aldehyde/cinnamaldehyde and hippuric acid in anhydrous acetic anhydride and catalytic Zn(OCOCH3)2·2H2O to ultrasonication at 35 KHz for 4 to 8 min. This method has many advantages: use of a green catalyst; yields are high, involves easy workup procedure, is energy efficient and economically feasible.

by Gianluca Donatini  , Sébastien Giraud  , Jean-Louis Kraimps  , Jérôme Danion  and Thierry Hauet

Received: 08 April 2019;  Published: 15 April 2019;  doi: 10.21926/obm.transplant.1902062

Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe hypoglycaemia events and impaired awareness of hypoglycaemia. Recent trials had demonstrated islet transplantation to be more effective than current medical treatment and improvements in outcomes also have been reported [...]

by Gerasimos Rigatos  , Masoud Abbaszadeh  , Bilal Sari  and Pierluigi Siano

Received: 07 December 2022;  Published: 11 May 2023;  doi: 10.21926/jept.2302018

The article aims at optimizing six-phase induction generator-based renewable energy systems (6-phase IGs or dual star induction generators) through a novel nonlinear optimal control method. Six-phase induction generators appear to be advantageous compared to three-phase synchronous or asynchronous power generators, in terms of fault tolerance and improved power generation rates. The dynamic model of the six-phase induction generator is first written in a nonlinear and multivariable state-space form. It is proven th [...]

by Gerhard Litscher  , Tong Li  and Fengxia Liang

Received: 14 March 2021;  Published: 15 March 2021;  doi: 10.21926/obm.icm.2101009

In a pioneer transcontinental pilot study conducted with 50 volunteers, it was revealed that women could have apparently overcome the world's toughest lockdown in terms of changes in the general state of health measured using the heart rate variability parameter better than men. The results of the present study obtained in Wuhan provide information on the initial trend in this regard.

by Gil Newburn  , Joshua P McGeown  , Eryn E Kwon  , Maryam Tayebi  , Paul Condron  , Taylor Emsden  , Samantha J Holdsworth  , Daniel M Cornfeld  and Graeme M Bydder

Received: 30 June 2023;  Published: 14 December 2023;  doi: 10.21926/obm.neurobiol.2304201

In modelling studies targeted MRI (tMRI) of small increases in the T1 of tissues using divided Subtracted Inversion Recovery (dSIR) sequences show ten or more times the contrast seen with conventional IR sequences. This may be particularly useful in imaging normal appearing white matter where there may be small changes in T1 and/or T2 in disease but these changes may be insufficient to produce useful contrast with conventional T2-weighted spin echo (T2-wSE) and T2-FLuid Attenuated Inversion Recovery (T2-FLAIR) sequ [...]

by Katharina Reichelt  , Ewan James  , Daniel Thompson  and Shaun Tanney

Received: 14 August 2022;  Published: 18 January 2023;  doi: 10.21926/obm.geriatr.2301222

This article discusses the findings from a training programme called ‘Communication and Interaction Training’ (CAIT). CAIT was designed to improve the confidence of carers in their use of communication skills with people living with dementia, particularly when managing behavioural agitation. This pre/post assessment study employed a mixed design, and showed positive effects in terms of quantitative and qualitative features. The participants were mainly from a specialist team who were experienced in managing episode [...]

by Gerhard Litscher

Received: 18 September 2022;  Published: 19 September 2022;  doi: 10.21926/obm.icm.2203042

This editorial briefly discusses the issue of potential toxicity in the case of long-term photobiomodulation (PBM). Scientific articles from PubMed, Google Scholar, and the China National Knowledge Infrastructure were included in a heterogeneous search. There have been very few studies on the long-term effects of PBM, as well as its potential toxicity. There is no evidence that PBM is toxic when used at therapeutic or imaging doses. There are no such concerns with intracranial PBM application (e.g., optical fiber) [...]

by Richell Booijink  and Ruchi Bansal

Received: 27 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.hg.1902024

Chronic liver diseases affects millions of people worldwide each year. Upon chronic liver injury, a wound healing process ensues, leading to the accumulation of extracellular matrix (ECM) proteins. If the injury persists, this leads to liver fibrosis with excessive scarring of the liver and loss of liver function. Lysophosphatidic acid (LPA), a signaling molecule has shown to be involved in various biological processes, including wound healing process. Elevated plasma levels of LPA and its catalyst autotaxin (ATX), [...]