by Rotu Arientare Rume  , Oyovwi Mega Obukohwo  , Ohwin Peggy Ejiro  and Oyelere Abosede Oreoluwa

Received: 04 December 2023;  Published: 27 February 2024;  doi: 10.21926/obm.icm.2401015

Regular physical activity has been proven to improve metabolism, slow aging, and decrease the likelihood of various health conditions such as obesity, type 2 diabetes, and cardiovascular disorders. Hence, dancing was evaluated for its effects on cardiovascular, liver enzymes, and biochemical markers among healthy adults. Forty (40) healthy adults (20-40 years old) were chosen for the study, with an average age calculated. Those with certain health conditions or habits were not allowed to participate. Twenty (20) me [...]

by Joseph S. D'Arrigo

Received: 08 December 2021;  Published: 29 March 2022;  doi: 10.21926/obm.neurobiol.2201117

Cerebrovascular atherosclerosis, and several other cardiovascular (or "inflamm-aging" type) diseases, are more frequent and advanced in subjects with Alzheimer's disease compared with normal aging. In addition, the observed pathogenic link to dementia (and its associated cerebral microvascular damage) is readily explained by alterations of arterial elasticity. A therapeutic strategy to delay dementia could be based upon localized drug delivery, using lipid nanocarriers (i.e., biobased nanoemulsion technology), targ [...]

by Rezarta Lalo  , Fatjona Kamberi  and Vjollca Ndreu

Received: 06 January 2023;  Published: 15 May 2023;  doi: 10.21926/obm.neurobiol.2302169

Pregnancy and postpartum periods are known as sensitive periods in women’s life and COVID-19 pandemic seems to be worsening their mental health with major impacts on exclusive breastfeeding duration. Therefore, the present study aims to fill the gap in the literature by assessing the links between postpartum anxiety and depression symptoms and breastfeeding duration as well as the associated factors during the COVID-19 pandemic. A longitudinal prospective observational study was conducted between November and [...]

by Hana Alharbi  and Miao He

Received: 16 April 2023;  Published: 31 August 2023;  doi: 10.21926/obm.genet.2303191

The aim of newborn screening (NBS) program is to detect and manage treatable conditions in the early stages prior to the occurrence of long-term and irreversible sequalae. Phenylketonuria was the first screened disorder, but panels rapidly expanded after the introduction of tandem mass spectrometry technology into the program. Significant differences in the diseases screened by NBS were noted between programs in United States. Therefore, the recommended uniform screening panel was developed in 2006 to include a lis [...]

by Fernando Cabo  and Isaac Aguaristi

Received: 01 April 2020;  Published: 02 April 2020;  doi: 10.21926/obm.icm.2002018

by Miles Nevills  , Spencer Jones  and Ethan Languri

Received: 31 October 2024;  Published: 24 June 2025;  doi: 10.21926/aeer.2502024

Across the industrial sector, compressed air is utilized as an easy-to-use and readily accessible tool in a variety of applications. This tool is commonly misunderstood as being more efficient than it is in reality. Air compression is energy intensive and thus both economically and environmentally costly. Compressed air typically only achieves around ~15% efficiency if judged by the energy delivered from the air, meaning approximately 5-6 kWh are wasted for every 1 kWh of useful work performed by compressed air. Du [...]

by Anita H Kelleher  and Angelos K Sikalidis

Received: 09 November 2020;  Published: 05 February 2021;  doi: 10.21926/obm.hg.2101056

The Mediterranean diet (MD) is considered one of the healthiest dietary patterns due to its rich provision of phytochemicals, antioxidants, vitamins, fiber, polyunsaturated, omega-3, and short-chain fatty acids through a variety of foods. The supply of such nutrients and bioactive components can support gut health and reduce systemic inflammation, with accumulating evidence from several human studies demonstrating the utility of the Mediterranean diet in the prevention of chronic and metabolic diseases. Further stu [...]

by Elham Amjad  and Babak Sokouti

Received: 21 February 2025;  Published: 09 June 2025;  doi: 10.21926/obm.transplant.2502251

Graft rejection, early allograft dysfunction (EAD), and poor diagnostic accuracy are some of the challenges that still need to be addressed, even though liver transplantation (LT) has the potential to help patients with end-stage liver disease (ESLD) significantly. Traditional procedures, such as liver biopsies and liver function tests (LFTs), often fail to identify abnormalities early and with accuracy. Genomic RNA sequencing (RNA-Seq) has recently emerged as a powerful approach for identifying molecular markers o [...]

by Hossein Hosseinkhani

Received: 26 August 2024;  Published: 12 December 2024;  doi: 10.21926/rpm.2404027

Viral and non-viral vectors for nucleic acids (DNA/RNA) therapeutics are important in development of pharmaceutical industries. Although viral vectors have shown significant impact in transfection of DNA/RNA, but numerus studies have shown that non-viral vectors are also effective for the safe and targeted delivery of DNA/RNA to exact location in the body with high percentage of efficacy, safety, and low-immunogenicity. It is also important to protect the nucleic acids from degradation and large-scale production ca [...]

by Giuseppe Cocco

Received: 20 March 2020;  Published: 01 April 2020;  doi: 10.21926/obm.geriatr.2002112

by Mohammed Naveed

Received: 22 December 2022;  Published: 12 April 2023;  doi: 10.21926/rpm.2302015

Composite materials with aluminum as matrix material have a wider amplitude of large-scale applications in engineering. Some salient features of aluminum matrix composites are, low density, low thermal coefficient of performance and low weight and high strength. Among the various series of aluminum alloy, Al6061 have been widely used by researchers due to its outstanding properties particularly as they are heat treatable. Aluminum 6061 alloys have been reinforced with various particulate reinforcements such as sili [...]

by Sai Batchu  , Michael J. Diaz  , Lauren Ladehoff  and Brandon Lucke-Wold

Received: 27 September 2022;  Published: 03 February 2023;  doi: 10.21926/obm.neurobiol.2301153

Genes encoding for proteins associated with the plasma membrane, referred to as the membranome, have long been recognized to play an important role in the development and maintenance of glioblastoma multiforme (GBM). GBM cell lines are commonly used to mimic tumors for in vitro experiments, but the extent to which they resemble GBM tumors in relation to the membranome is unclear. The present study explores the resemblance of GBM cell lines to primary tumors regarding membranome expression. Gene expression data was [...]

by Andrey Koptyug  , Yurij Sukhovei  , Elena Kostolomova  , Irina Unger  and Vladimir A. Kozlov

Received: 14 April 2023;  Published: 22 December 2023;  doi: 10.21926/obm.geriatr.2304263

Understanding processes related to human aging and rejuvenation relies on experimental data and advanced models operating at different levels. There are several existing conceptual and specific modeling approaches. However, one of the existing tasks is compiling generic models linking properties at cell and cell-element levels to properties at systemic levels - tissue, organ, and whole body. One of the critical issues in the relevant models is the enormity of interacting components at the cell and sub-cell levels n [...]

by Ousman Bajinka  , Mamtuti Panneh  , Sang Mendy  , Amadou Barrow  , Haddy Bah  , Lamarana Jallow  , Jarry Jallow  , Kaddy Drammeh  , Kaddijatou Kah  , Oulimatou Lateef  , Mariama A Bah  , Isatou K Sillah  , Fatoumata Bah  , Nyima Ceesay  , Mariama Jaiteh  and Yurong Tan

Received: 31 August 2024;  Published: 08 April 2025;  doi: 10.21926/rpn.2502006

The adverse effects of maternal passive smoking during pregnancy on offspring health remain understudied in sub-Saharan Africa, particularly in The Gambia, where smoke-free regulations are limited. To determine the prevalence of maternal passive smoking (MPS) during pregnancy and investigate its associations with adverse pregnancy outcomes and offspring health complications in The Gambia. A cross-sectional study was conducted in February 2023 among 401 mothers with children under 5 years in urban and rural regions [...]

by Katarina Tomulic Brusich

Received: 30 August 2022;  Published: 15 November 2022;  doi: 10.21926/obm.transplant.2204169

Transplantation is a widely accepted and successful life-saving treatment for hundreds of thousands of patients. However, transplant medicine still faces a number of obstacles. One of the most significant is the large disparity between the number of donors and recipients and the growing need for re-transplantation. In the last two decades, the improvement and organization of the national transplantation program in Croatia have resulted in a steadily increasing donor rate and therefore the transplantation numbers. A [...]

by Marco Minella  , Khan M.G. Mostofa  , Cong-qiang Liu  and Davide Vione

Received: 05 September 2019;  Published: 21 January 2020;  doi: 10.21926/obm.acr.2001004

Superoxide, produced photochemically as well as microbially, is an important reactant present in seawater and a major source of hydrogen peroxide. Superoxide decay may occur through catalyzed or uncatalyzed dismutation forming H2O2 and O2, through oxidation to O2, or through reduction into H2O2. Under definite circumstances, the redox processes that are different from dismutation could produce or consume H+, thereby altering the pH of seawater. In order to alter the pH, these processes have to involve, together wit [...]

by Mahintaj Dara  , Zahra Karimi  , Mehdi Dianatpour  and Hadi Aligholi

Received: 02 June 2024;  Published: 30 September 2024;  doi: 10.21926/obm.neurobiol.2403246

Zebrafish (Danio rerio) is a vertebrate with unique characteristics, making it an excellent biomedical research animal model. One research area involves investigating changes in gene expression during neurodegenerative processes, aging-related changes, and behavioral studies in zebrafish. To achieve this, high-quality and quantity RNA must be extracted from zebrafish. This study aims to develop an optimized RNA extraction method from zebrafish larvae brains. After rearing and maintaining the zebrafish in suitable c [...]

by Gopi Battineni  , Mohammad Amran Hossain  , Nalini Chintalapudi  , Giulio Nittari  , Ciro Ruocco  , Enea Traini  and Francesco Amenta

Received: 29 June 2022;  Published: 03 January 2023;  doi: 10.21926/obm.geriatr.2301220

The increasing incidence of adult-onset dementia disorders and primarily Alzheimer’s disease (AD) among the aging population around the world is increasing the social and economic burden on society and healthcare systems. This paper presents three neural networking algorithms: MobileNet, Artificial Neural Networks (ANN), and DenseNet for AD classification based on MRI imaging data. The results of each model were compared in terms of performance metrics such as accuracy, true positive rate, and receiver operating cu [...]

by Marek Łożyński  , Iwona Mądrzak-Litwa  and Aleksandra Borowiak-Resterna

Received: 29 June 2020;  Published: 27 August 2020;  doi: 10.21926/acr.2003007

1-Decylbenzimidazole (dbim) copper(II) complexes formed during solvent extraction were thoroughly studied, and their structures were predicted. Density functional theory (DFT) calculations of their structures and Time-dependent DFT (TD-DFT) calculations of their spectra indicated that 1-decylbenzimidazole forms both mono- and binuclear complexes with copper(II), with coordination numbers of 4 or 5. At the molar ratio of [Cu(II)]aq/[dbim]org ≥ 1 and at [Cl-]aq ≥ 0.9 mol dm-3 in the extraction media, a binuclear 1:1 [...]

by Axel Ferreira  , Filipa Guimarães  and Paulo Simões Coelho

Received: 29 September 2020;  Published: 24 December 2020;  doi: 10.21926/obm.geriatr.2004145

We present a case of a 74-year-old woman with deep intracerebral hemorrhage (ICH), probable cerebral amyloid angiopathy (CAA), and probable antiphospholipid syndrome (APS). Due to the high hemorrhagic risk, it was decided not to use anticoagulants. In a period of three months, she had two separate cerebral ischemic events and died of stroke-related complications. The use of oral anticoagulation (OAC) in this patient is neither supported nor contra-indicated by current literature, even though past medical history su [...]

by Gerhard Litscher

Received: 05 January 2025;  Published: 07 January 2025;  doi: 10.21926/obm.icm.2501003

Acupuncture, an ancient practice in traditional Chinese medicine, is founded on understanding of human physiology and the dynamics of energy flow (Qi). The emergence of artificial intelligence (AI) in modern medicine presents opportunities to integrate advanced technologies into acupuncture, enhancing diagnostic precision and empirical validation. AI tools can analyze complex datasets, model energy flow dynamics, and provide evidence-based insights, potentially bridging traditional methodologies with scientific par [...]

by Christopher Igwe Idumah  , Ifeanyi Emmanuel Okoye  and Chioma Joan Ikebudu

Received: 05 September 2024;  Published: 02 February 2025;  doi: 10.21926/rpm.2501005

3-Dimension printing (3-DPT) or additive manufacturing (AM) technology has been utilized for a while in the construction of customized 3-D objects utilizing computer software such as computer-aided design (CAD). However, the emergence of an innovative and new four-dimensional printing (4-DPT) has enabled the synergy of AM technology with programmable materials in transforming digital processes virtually into physical entities, thereby providing innovation and advanced functionalities. 4-DPT is a procedure facilitat [...]

by Giacomo Farì  , Enrica Chiaia Noya  , Laura Dell'Anna  , Vincenzo Ricci  , Francesco Quarta  , Laura Masiero  , Andrea Bernetti  , Marisa Megna  and Maurizio Ranieri

Received: 16 January 2024;  Published: 25 June 2024;  doi: 10.21926/obm.neurobiol.2402227

Wheelchair basketball (WB) is a health and inclusion opportunity for people with disabilities. In the scientific literature, no evidence defines WB as a symmetrical or asymmetrical sport; however, it would be helpful to deepen this aspect because it could improve the quality of training programs and consequently speed up WB performance. In WB, the biomechanical role of the shoulders is crucial. Therefore, the symmetry index and the activation of the bilateral supraspinatus and biceps brachii muscles were investigat [...]

by Despina Vamvuka  , Katerina Esser  , Dimitrios Marinakis  and George Kalantzakis

Received: 02 November 2022;  Published: 11 January 2023;  doi: 10.21926/aeer.2301005

This work aimed at evaluating all products from the low-temperature pyrolysis (350°C) of some industrial wastes, cotton stems and seeds (CSS), grape husks and curls (GRH), undigested sewage sludge (USS) and their blends in a fixed bed system and suggesting their possible applications. Solid and liquid products, biochars, and bio-oils were analyzed using various techniques by physicochemical, mineralogical, and chemical analyses. Gases were qualitatively and quantitatively analyzed using a thermogravimetric-mass [...]

by Buti Obaid Saeed Alfalahi  , Imane Lamdjad  , Mustafa Alnujaifi  , Noaman Atallah Alheety  and Abdul Qayyum

Received: 05 February 2024;  Published: 12 June 2024;  doi: 10.21926/obm.genet.2402242

Understanding the impact of melatonin (N-acetyl-5-methoxytryptamine) on plant gene expression is crucial for unlocking its full potential as a tool for crop improvement and stress tolerance. Melatonin has emerged to have several influences on the transcriptional activity of numerous genes, helping to orchestrate plant responses to environmental cues. Furthermore, it has been shown that melatonin signaling pathways control downstream gene expression to ensure proper plant growth and development. Therefore, clearing [...]