by Alessandro Luigi Rossi  , Vincenzo Capilupi  , David Palombo  , Luigi Tagliatesta  , Tecla Terenzio  , Marco Vitali  and Matteo Chiapasco

Received: 29 April 2019;  Published: 30 August 2019;  doi: 10.21926/obm.hg.1903035

OBJECTIVES To review current literature analysing possible secondary complications in response to the administration of paracetamol and codeine as analgesics in the dental field. To discuss a case of secondary acute pancreatitis triggered by the administration of both active ingredients. MATERIALS AND METHODS A 28-year-old patient, without any pancreatic or hepatobiliary condition was diagnosed with acute pancreatitis 3 hours after taking paracetamol 500mg and codeine 30mg prescribed as pain-relief therapy after ex [...]

by Gerhard Litscher

Received: 18 January 2021;  Published: 20 January 2021;  doi: 10.21926/obm.icm.2101003

Neuro-photobiomodulation (PBM) is a relatively novel optical stimulation method that is not yet generally accepted in conventional medicine. Therefore, evidence-based research in this sub-area, which is important for laser medicine, is necessary in order to provide appropriate scientific evidence for a better understanding of neuro-PBM. In this editorial, a summary of the recent results with stimulation using different frequencies (e.g., 40 Hz, 136.1 Hz) is presented. The contribution is intended to stimulate resea [...]

by Jessica R Turnbull  , Jenna Vyas-Lee  and Sally Hobson

Received: 17 November 2020;  Published: 06 May 2021;  doi: 10.21926/obm.neurobiol.2102094

Sleep-related difficulties are common in children with neurodevelopmental disabilities. Poor sleep health is associated with detrimental impacts not only for the child/young person, but also their family members. Exercise is considered to be important for sleep health, improving duration and quality of sleep in adult studies, however there is limited literature on impact in children with neurodevelopmental disabilities, and barriers to participation exist for this group. We set out to test the feasibility and accep [...]

by Nasim Foroughi  , Brooke Donnelly  , Mark Williams  , Sloane Madden  , Michael Kohn  , Simon Clarke  , Perminder Sachdev  , Stephen Touyz  and Phillipa Hay

Received: 01 June 2021;  Published: 30 September 2021;  doi: 10.21926/obm.neurobiol.2103107

To compare neural responses to high and low-energy food images in patients with Anorexia Nervosa (AN) and an age-matched Healthy Control (HC) group. 25 adolescents with AN and 21 HCs completed a diagnostic interview, self-report questionnaires and fMRI, during which they viewed food images evoking responses of disgust, happiness, or fear. Following whole brain analyses, neural responses in six regions of interest were examined in a series of between-group contrasts, across the three emotive categories. Compared to [...]

by Masahiro Sato  , Emi Inada  , Shingo Nakamura  and Issei Saitoh

Received: 28 March 2018;  Published: 02 August 2018;  doi: 10.21926/obm.transplant.1803016

Background: Transplantation of isolated islets is one of the most powerful approaches to cure insulin-dependent (type I) diabetes mellitus (IDDM). Currently, the most widely used transplantation strategy is percutaneous perfusion into the liver via the portal vein. However, this approach has several drawbacks and is often limited by the large number of islets required and hypoxic damage to the grafts. Methods: In this article, we posit intrapancreatic parenchymal cell transplantation (IPPCT) as a promisin [...]

by Vincent Anayochukwu Ani

Received: 06 August 2023;  Published: 24 January 2024;  doi: 10.21926/jept.2401002

Energy is a prerequisite to running health facilities and is, therefore, key to the success of the service. Karshi primary healthcare centre (PHC) facility is confronted with an unreliable power supply that leads to a high cost of generating power from diesel to operate its equipment. This facility needs a sustainable and reliable electricity supply and therefore a change in their energy system to enable it improve its quality of healthcare delivery services. A solar energy-based electricity generation system that [...]

by Grace Douglas  , Andrew S Day  and Stephanie C Brown

Received: 23 August 2024;  Published: 13 December 2024;  doi: 10.21926/rpn.2404020

Dietary and nutritional interventions have been shown to have roles in managing active Crohn disease (CD), with exclusive enteral nutrition (EEN) being recommended as the preferred initial treatment in children following diagnosis. In recent years, other nutritional interventions such as the Crohn's disease exclusion diet (CDED) have been considered and evaluated for induction therapy. To date, the long-term benefits of CDED have not been established. This report highlights the outcomes of the prolonged use of CDED [...]

by Peter Newman  and Marie Verschuer

Received: 27 February 2023;  Published: 17 November 2023;  doi: 10.21926/jept.2304036

The transition to net zero cities is a pivotal challenge in the face of climate change. This research introduces a novel methodology termed "Net Zero Corridors," which emphasizes a bottom-up approach to decarbonize urban power and transport systems. By focusing on urban corridors, this method integrates distributed power systems with urban transport, offering a localized solution to the broader challenge of urban decarbonization. Drawing from urban fabric theory and urban metabolism data, the study provides insight [...]

by Vipin Kumar Sharma  , Sunil Kumar Thamida  , B. Naveen Kumar Reddy  and Raja Sinha

Received: 28 November 2024;  Published: 07 May 2025;  doi: 10.21926/aeer.2502022

The hydrocarbon sector in India plays a pivotal role in the country's energy landscape, encompassing exploration, production, refining, and distribution activities. This abstract provides a concise overview of the sector's current status, challenges, and prospects. India's hydrocarbon reserves range from conventional to unconventional sources, with significant potential yet to be tapped. However, the sector faces challenges such as declining production from mature fields, technological limitations in ex [...]

by Dean M. Cordingley  and Stephen M. Cornish

Received: 29 April 2022;  Published: 07 July 2022;  doi: 10.21926/obm.icm.2203025

Sarcopenia is the age-related loss of muscle mass and strength which is associated with the loss of physical performance, lower quality of life, and other negative health outcomes. Resistance training (RT) is a recognized method to increase muscle strength and mass, however some older adults may be limited in their ability to perform RT with traditionally recommended higher-loads. Occluding blood flow to a limb, commonly referred to as muscle blood flow restriction (MBFR), has been investigated as an adjunct to RT [...]

by Lordwin Girish Kumar Jeyakumar  , David B. McKenzie  , Laura E. Christianson  and Evan Derdall

Received: 29 December 2020;  Published: 15 April 2021;  doi: 10.21926/aeer.2102005

Denitrifying bioreactor technology, where a solid carbon source (woodchips) acts as a reactive medium to intercept agricultural tile drainage water, has been successfully used to convert N (NO3-) to di-nitrogen (N2) gas. Four replicated field-scale (24 m long × 3 m wide × 1 m deep), bioreactors were built and operated at the St. John's Research and Development Centre and were successful at removing a notable amount of nitrate (N) from agricultural subsurface drainage water. The objective of this study [...]

by Luis F. Riquelme  , Sara Diab  , Angela Horyacheva  , Isabel Huribal  , Andreea Shellerud  , Sophia Werden Abrams  and Ashwini M. Namasivayam-MacDonald

Received: 29 April 2022;  Published: 11 August 2022;  doi: 10.21926/obm.icm.2203036

The purpose of this study was to collate and summarize the content covered in published literature describing speech-language pathology management of adult patients with COVID-19 in the acute hospital setting as of February 2022. This review serves as an updated review of the initial recommendations to guide speech-language pathology management for adults with COVID-19 in the acute hospital setting previously provided by Namasivayam-MacDonald and Riquelme in July of 2020. This scoping review followed the Preferred [...]

by Zaid Albayati  , Sally Heyworth  , Jane Moberly  , Derek Middleton  , Brian Flanagan  , Abdul Hammad  and Stephen E Christmas

Received: 10 October 2018;  Published: 14 December 2018;  doi: 10.21926/obm.transplant.1804032

Background:HLA-G is an immunosuppressive molecule with a potential role in allograft acceptance. Methods:Expression of HLA-G on leucocyte subpopulations was studied in a group of 21 renal transplant patients immediately prior to and 2 months post-transplantation. Results:Significant increases in proportions of total HLA-G+CD4+ T cells were seen (0.5+/-0.1% to 7.9+/-3.2%; p<0.01) and also for CD45RA+, CD45RO+ and CD69+ subsets. Increases in proportions of HLA-G+ cells were also seen in CD8+ T cells and their [...]

by Yoko Kawamura

Received: 15 May 2025;  Published: 30 October 2025;  doi: 10.21926/obm.geriatr.2504329

In Japan, a super-aging society, the development of Ikigai is considered the key to extending healthy longevity in national policy. Thus, activities provided by local governments are designed to encourage Ikigai. At this point, Ikigai has developed its conceptual understanding, which includes its distinctiveness from life purposes and other closely related concepts. Empirical studies using developed measurements have shown that Ikigai has an impact on the mental and physical health of older adults across countries [...]

by Elisavet Kouvidi  , Haralambia Tsarouha  , Christina Katsidi  , Sophia Zachaki  , Nikolaos Nitsos  , Sofia Samourgianidi  , Amelia Pantou  , Lazaros Leandros  , Emmanouel Kanavakis  and Ariadni Mavrou

Received: 21 October 2022;  Published: 08 February 2023;  doi: 10.21926/obm.genet.2301178

Chromosomal abnormalities represent a significant genetic cause of male infertility because they impair spermatogenesis. The objective of the current study was to determine the prevalence and distribution of chromosomal abnormalities in Greek men with infertility. Four hundred eighty-eight infertile men (27 azoospermic, 168 with oligospermia -98 mild, 57 moderate, 13 severe- and 293 with normospermia) undergoing In Vitro Fertilization (IVF) between 2016-2022 were enrolled in the study. Thirty-eight fertile men were [...]

by Joseph S. D'Arrigo

Received: 27 December 2018;  Published: 17 June 2019;  doi: 10.21926/obm.geriatr.1902057

Much evidence has been published which indicates that microvascular endothelial dysfunction, due to cerebrovascular risk factors (e.g., atherosclerosis, hypertension, obesity, diabetes, smoking, aging), precedes cognitive decline in Alzheimer's disease and contributes to its pathogenesis. By incorporating appropriate drug(s) into biomimetic (lipid cubic phase) nanocarriers, one obtains a multitasking combination therapeutic which targets certain cell-surface scavenger receptors, and crosses the blood-brain barrier [...]

by Hong Chee Chew  , Ling Gao  , Jeanette E. Villaneuva  , Aoife Doyle  , Mark Hicks  , Andrew Jabbour  , Kumud K. Dhital  and Peter S. Macdonald

Received: 09 March 2019;  Published: 18 June 2019;  doi: 10.21926/obm.transplant.1902067

Background: Normothermic machine perfusion (NMP) utilises 1.2-1.5L of donor blood (DB) with a target perfusate haematocrit of 25% to reanimate the donor heart. Limitations to current practise include small donor size and donor anaemia which can impact on the recovery of these hearts. Furthermore, in donation after circulatory death (DCD), blood collection may delay delivery of preservation solutions resulting in longer warm ischaemic times for the heart and other organs. Banked blood (BB) is a potential alternative [...]

by Mamun Mahmud  and Md. Mujahid Hasan

Received: 06 September 2024;  Published: 20 January 2025;  doi: 10.21926/aeer.2501008

The concentration of heavy metals in road dust poses significant risks to human health and the environment. This study investigates the characteristics of road dust, focusing on the contamination level of heavy metals like lead (Pb), iron (Fe), and arsenic (As). Road dust samples were collected from various locations in Khulna city. They went through acid digestion to determine the Pb, Fe, and As levels using ICP-OES, and bioavailable iron was assessed by mixing the dust samples with water. This study found no dete [...]

by Fawzy Georges

Received: 21 April 2020;  Published: 13 August 2020;  doi: 10.21926/obm.genet.2003115

The challenges which face the world today can be summed up in a few words: An increasingly congested world with dwindling areas of viable cultivated land and accelerating climate instability. The combined effect of these realities, together with the trend of striving to extend the average human life, puts the world on the path toward future catastrophe. This situation makes it imperative to seek realistic and practical solutions, which must be able to address food shortages and climate problems in a timely manner. [...]

by Jun Gu  , Wei Wang  , Guilin Tang  , Gokce A. Toruner  , Ming Zhao  , Steven Sfamenos  , Zhenya Tang  , Joseph D. Khoury  and L. Jeffrey Medeiros

Received: 13 October 2020;  Published: 07 December 2020;  doi: 10.21926/obm.transplant.2004128

Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). DCL might represent up to 5% of the post-HSCT disease relapses, but case numbers reported in the literature might underestimate the frequency. The leukemogenesis of DCL is not well understood due to the limited numbers of cases reported and lack of detailed molecular genetic information from recipients and donors. Although many theories have been proposed for leukemogenesis of DCL, the underl [...]

by Mouna Daldoul  , Rim Charfi  , Khouloud Ferchichi  , Mouna Ben Sassi  , Syrine Ben Hammamia  , Fatma Medhioub  , Emna Gaies  , Rym Enneifer  , Hanene Eljebari  , Anis Klouz  , Riadh Daghfous  and Sameh Trabelsi

Received: 20 August 2024;  Published: 13 December 2024;  doi: 10.21926/obm.transplant.2404228

A high intra and interindividual pharmacokinetics variability characterize Tacrolimus. Data regarding factors influencing its pharmacokinetics and pharmacodynamics in liver transplantation are limited. This study aimed to assess tacrolimus therapeutic response, pharmacokinetics and adherence in liver transplant recipients. The study was conducted at the Clinical Pharmacology Department for 12 years, from January 2009 to March 2021. We included liver transplant patients treated with tacrolimus referred to our depart [...]

by Satchit Anand Saha  , Katelyn Ann Williams  , George Murphy  and Sandeep Ajoy Saha

Received: 24 September 2023;  Published: 09 January 2024;  doi: 10.21926/obm.icm.2401006

Food insecurity and insufficient access to affordable nutrition have been associated with increased risk for the development of multiple chronic medical conditions, including cardiovascular disease. In this narrative review, we explore the association between food insecurity and the development of chronic medical conditions that confer increased cardiometabolic risk, cardiovascular disease, and mortality. We also identify the various barriers leading to food insecurity and lack of food literacy, with an emphasis on [...]

by Steven R. Brenner

Received: 29 August 2018;  Published: 26 February 2019;  doi: 10.21926/obm.geriatr.1901035

Alzheimer Disease may result from excessive stimulation of the innate immune system from development of underlying opportunistic infections and impaired age related self-recognition as non-self, due to immunodeficiency and immunosenescence, resulting in excessive inflammation and runaway Beta-amyloid production (a component of the innate immune system) causing cytosolic calcium overload. Excessive cytosolic calcium may cause over activation of calcineurin and inactivation of cis-trans prolyl isomerase (Pin1), with [...]

by Birthe Osorio  and Karsten Münstedt

Received: 27 February 2019;  Published: 05 July 2019;  doi: 10.21926/obm.icm.1903043

Background: In particular, the women with breast cancer seek methods offered by complementary and alternative medicine (CAM). Unfortunately, the value of most of such methods remains unclear. Methods: The present review was aimed at identifying reasonable strategies for patients with breast cancer on the basis of the current literature. Results: The analyses revealed that there is no evidence of alternative medicine which might result in healing. However, several strategies are available which could improve patient [...]

by Roberto Anaya-Fernández  , Roberto Anaya-Prado  , Michelle M. Anaya-Fernández  , Miguel A. Guerrero-Palomera  , Ivan F. Garcia-Ramirez  , Daniel Gonzalez-Martinez  , Consuelo C. Azcona-Ramirez  , Citlalli S. Guerrero-Palomera  , Claudia Garcia-Perez  , Bernardo Tenorio-Gonzalez  , Jose E. Tenorio-Gonzalez  , Laisha F. Vargas-Ascencio  , Abraham I. Canseco-Villegas  , Gustavo Servin-Romero  , Allen R. Barragan-Arias  and Bruno Reyna-Rodriguez

Received: 02 May 2024;  Published: 07 August 2024;  doi: 10.21926/obm.neurobiol.2403239

Oxidative stress in cerebral ischemia/reperfusion injury (CIRI) involves reactive oxygen and nitrogen species (ROS and RNS). Despite efficient antioxidant pathways in the brain, hypoxia triggers the production of oxygen free radicals and downregulates ATP, which leads to oxidative stress. Sources of free radicals during CIRI include Ca2+-dependent enzymes, phospholipid degradation and mitochondrial enlargement. Upon reperfusion, the abrupt increase of oxygen triggers a massive radical production via enzymes like xa [...]