by Musa Itopa Yakubu  , Nuhu Mohammed Danjamu  , Mohammed Garba Magaji  , Sani Malami  , Axel Becker  , Medinat Yakubu Abbas  and Ben Ahmed Chindo

Received: 25 February 2022;  Published: 31 March 2022;  doi: 10.21926/obm.icm.2201013

Preparations of Zingiber officinale are used in Nigerian folk medicine to manage colds, pain, arthritis, nausea, and epilepsy. The ameliorative effects of co-administering aqueous Zingiber officinale extract (GE) and sodium valproate (SDV) on pentylenetetrazole-kindled mice were evaluated regarding cognitive deficits, neuronal cell loss, and seizure severity. GFAP was also quantified. Male mice were pretreated with GE (50 mg/kg), SDV (100 and 200 mg/kg), and GE + SDV before kindling. After kindling, the mice underw [...]

by Martin Wynn  and Peter Jones

Received: 06 September 2023;  Published: 07 December 2023;  doi: 10.21926/aeer.2304053

While artificial intelligence has been attracting increasing investment and controversy, a new, and potentially much more powerful technology, Quantum Computing, is on the business horizon. Already, organizations are assessing its potential for addressing a range of computationally challenging issues, such as last-mile optimization and cryptanalysis to break encryption algorithms, and are exploring possible applications in a range of business areas. While the advent of Quantum Computing may bring an array of opport [...]

by Chloe Moran  , Hannah Shaw  , Sue Black  and Kay Brewster

Received: 29 July 2022;  Published: 16 January 2023;  doi: 10.21926/obm.icm.2301006

There is increasing evidence for the effectiveness of brief, group-based compassionate mind training (CMT) in reducing shame and self-criticism, and increasing self-compassion. The current evaluation of an 8-week CMT group programme in an NHS Physical Health Psychology Service supports these findings. Based on a cross-diagnostic sample of 25-39 participants with physical health difficulties, results demonstrate significant reduction in depression and anxiety, significant increase in perceived wellbeing and acceptan [...]

by Jiankang Jin  , Shumei Song  and Jaffer A. Ajani

Received: 30 June 2020;  Published: 16 September 2020;  doi: 10.21926/obm.genet.2003116

Gastric adenocarcinoma (GAC) is among the three most common cancers in the world. The majority of GAC patients are diagnosed in an advanced stage and have a median survival of ~9 months. There are limited effective therapeutic strategies available in the clinic and currently U.S. Food and Drug Administration (FDA) approved immune therapy is programmed death-1 (PD-1) antibodies (e.g. pembrolizumab) but only a few patients seem to benefit. Transformation to cancer occurs when multiple genes and cellular pathways are [...]

by Paul M. Valliant  , Charlotte Aelick  , Amber Sinclair  and Joseph M. Caswell

Received: 07 August 2018;  Published: 18 October 2018;  doi: 10.21926/obm.geriatr.1804015

Background: Previous research has indicated the attitudes that others have toward older adults play an important role in their well-being. The current study contributes to the literature because it evaluates attitudes toward older adults. Methods: The participants included Caucasian and Indigenous people residing in Northern Ontario. All participants were asked to complete a demographics questionnaire and the Kogan’s Attitudes Toward Old People Scale (KAOP). Results: Results indicated that Indigenous participants h [...]

by Sue Westwood  , Trish Hafford-Letchfield  and Jemma James

Received: 16 October 2023;  Published: 21 February 2024;  doi: 10.21926/obm.geriatr.2401270

Research suggests health, social care, and social work professionals who are highly religious, and adhere closely to traditional doctrine, are more likely to take a negative view of LGBTQ people. This includes those who provide services to older people. Negative attitudes towards lesbian, gay, bisexual, trans and/or queer (LGBTQ) people can translate into poor care and even abuse. This commentary discusses recent literature on older LGBTQ people’s experiences of religious abuse. It highlights the concerns among man [...]

by Michael Czapka  , Carlos A.Q. Santos  and Laurie A. Proia

Received: 08 October 2018;  Published: 31 January 2019;  doi: 10.21926/obm.transplant.1901045

Mucormycosis is a rare fungal infection associated with high morbidity and mortality that typically afflicts immunocompromised hosts. We present a case of isolated hepatic mucormycosis with Rhizopus spp. that developed in the early post-transplant period. Initial presentation was concerning for allograft rejection, but definitive diagnosis was made with histopathology and fungal culture. The patient had a favourable outcome with surgical resection, a course of liposomal amphotericin B combined with micafungin, and [...]

by Emily Beitzell  , Purnaja Podduturi  , Megan Hook  , Amelia Jones  , Haley McKeen  and Miriam Liss

Received: 03 October 2021;  Published: 01 December 2021;  doi: 10.21926/obm.icm.2104053

The coronavirus (COVID-19) pandemic has produced a global mental health crisis and many individuals have obsessive thoughts and worry about COVID-19 which may, both directly and indirectly, relate to more general anxiety. This study explored anxiety sensitivity and mindful awareness as mediators in the relationship between COVID-19 obsession and general anxiety. College student participants (N = 172) completed the Obsession with COVID-19 scale, the Anxiety Sensitivity Index, the awareness subscale of the Five Facto [...]

by Lisa Grentz  , Kristin Furfari  and Rebekah Keifer

Received: 13 January 2024;  Published: 19 April 2024;  doi: 10.21926/rpn.2402007

Infants with a critical congenital heart defect are at high-risk for feeding difficulties, often necessitating feeding tube placement. Enteral nutrition (EN) support is initiated to meet nutritional requirements and promote growth pre- and post-operatively. Tube-fed infants with congenital heart disease (CHD) who achieve stable health status post-operatively are at risk of becoming feeding tube dependent (FTD). We report a clinical observation for infants with CHD based on survey results from Growing Independent Ea [...]

by Mauro Turrin  , Barbara Mariotti  , Isabella Schiavon  and Serena Battista

Received: 29 September 2019;  Published: 22 November 2019;  doi: 10.21926/obm.hg.1904040

Hypereosinophilic syndrome is currently defined by an absolute blood eosinophil count of more of 1500 cell per μL for more than 1 month and by multiorgan system infiltration. Eosinophilic colitis is an exceptionally rare inflammatory condition in which eosinophils infiltrate the colonic gut. It represents the least frequent manifestation of the wide spectrum of eosinophilic gastrointestinal disorders. We describe a case of an adult male patient with persistent eosinophilia for at least twenty-five years. During thi [...]

by Kenji Morita  and Bun Tsuchiya

Received: 26 March 2021;  Published: 24 June 2021;  doi: 10.21926/jept.2102029

In this review, various studies on the Li depth profiles of metal/electrolyte/metal capacitors and batteries of Au/LCO/LATP/Pt, LCO/LiPON/Si, and LMO/LiPON/NbO with different metal electrodes at both sides (by bias; LCO =LiCoO2, LATP =Li3.1Al0.86Ti1.14Ge1.27P1.73O12, LMO =LiMn2O4, NbO = Nb2O5) using the in-situ reflection ERD (ERD) technique with 9MeV O+4 ion beam and transmission ERD (TERD) technique with 5MeV He+2 ion beam, respectively, are described. For capacitors, the transport fraction of Li-ion in the elect [...]

by Sheri Tran  and Mark M Fuster

Received: 16 July 2017;  Published: 12 September 2017;  doi: 10.21926/obm.transplant.1703004

The risk for developing a variety of malignancies is significantly elevated in the setting of lung transplantation. Malignancy remains among the three major causes of death in post-transplant recipients, and the relatively high risk of cancer development as well as metastatic aggression pose special threats to this population due to the need for continued immunosuppression. A variety of risks such as tobacco use and inflammatory lung diseases that led to the lung pathology prompting lung transplantation, in additio [...]

by Katerina G. Oikonomou  and Sarah Taimur

Received: 14 February 2019;  Published: 17 June 2019;  doi: 10.21926/obm.transplant.1902066

In non-endemic regions of the world, human T-cell lymphotropic virus type-1 (HTLV-1) is an uncommon pathogen in the transplant host, but can be associated with significant morbidity and mortality. Careful assessment for risk factors, targeted screening and heightened awareness of the clinical presentation of HTLV-1 associated disease is necessary for timely recognition and management in the transplant host. The use of antiretroviral agents in the management of symptomatic disease due to HTLV-1 remains controversial [...]

by Mikhail Granovskiy

Received: 17 October 2023;  Published: 14 November 2023;  doi: 10.21926/jept.2304034

According to the United States Department of Energy, waste heat recovery would allow up to a 20% reduction in greenhouse gases (GHG) emission. Most of the waste energy is discharged as a low-grade heat at temperatures less than 250°C. Therefore, the development of new technologies and the enhancement of existing ones to convert low-grade heat into electrical or mechanical energy are of great importance. The working principle of adsorption-desorption heat pumps with cyclic switching between adsorption and desorp [...]

by Jessica Turnbull  , Sally Hobson  , Jenna Vyas-Lee  and Bidisha Lahoti

Received: 31 January 2021;  Published: 15 June 2021;  doi: 10.21926/obm.neurobiol.2102101

We describe our experience of setting up and evaluating a community-based multi-disciplinary sleep service for children with neurodevelopmental disorders and psychosocial vulnerabilities.Referrals are accepted for children (1-18 years of age) with persistent sleep problems, and neurodevelopmental difficulties or significant psychosocial adversity, living in two inner-city boroughs.Holistic sleep assessment involves 1-hour Paediatrician-led consultation, often followed by Psychologist-led parent workshop, with follo [...]

by Keith A. Wollen  and John W. Hoyt

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows significant preservation of cognition and quality of life in the daily routine of a woman with severe Alzheimer’s who was given multiple therapeutic interventions. Alzheimer’s disease involves multiple d [...]

by Khawla F. Ali  , Vicente T. San Martin  , Tyler Stevens  , R. Matthew Walsh  , Rita Bottino  , Massimo Trucco  and Betul Hatipoglu

Received: 29 March 2018;  Published: 02 July 2018;  doi: 10.21926/obm.transplant.1803014

Total pancreatectomy (TP) is increasingly being utilized for definitive treatment in patients with debilitating chronic pancreatitis (CP). In an effort to prevent surgical diabetes, the procedure can be performed in conjunction with transplantation of islets of Langerhans recovered from the patients’ own resected pancreas (autologous islet transplantation, AIT). Given that patients undergoing TP and AIT are traditionally assumed not to be at risk for the development of beta-cell autoimmunity, it is possible that th [...]

by Qiqi Yu  , Kran Suknuntha  , Weixiong Zhong  , Daniel R. Matson  , Aaron S. Hess  and William N. Rose

Received: 13 February 2022;  Published: 02 June 2022;  doi: 10.21926/obm.transplant.2202160

We report a case of thrombotic microangiopathy (TMA) diagnosed in the kidney allograft of a 59-year-old woman who had developed plasmacytoma type monomorphic posttransplant lymphoproliferative disorder (PTLD) 30 years after a simultaneous pancreas and kidney transplant. This report demonstrates a rare etiology of TMA in a kidney allograft occurring in association with PTLD-associated monoclonal gammopathy. The main teaching points are: 1) PTLD may be considered in the work-up of a new TMA in the immunosuppressed po [...]

by Robert F. Miller  , Laurence Huang  and Peter D. Walzer

Received: 14 September 2018;  Published: 25 October 2018;  doi: 10.21926/obm.genet.1804045

Background: Over the past decade, there has been rising interest in the interaction of Pneumocystis with the environment. This interest has arisen in part from the demonstration that environmental factors have important effects on the viability and transmission of microbes, including Pneumocystis. Environmental factors include climatological factors such as temperature, humidity, and precipitation, and air pollution factors including carbon monoxide, nitrogen dioxide, sulfur dioxide, and particulate matter. Methods [...]

by James S. Powers  , Destiny O. Birdsong  , Kemberlee R. Bonnet  , Neena R. Kapoor  , Jamaria J. Southward  , Ifeoma Nwankwo  and David G. Schlundt

Received: 25 April 2019;  Published: 26 August 2019;  doi: 10.21926/obm.geriatr.1903072

Background: Narratives encompass written reflection experiences and hold the potential to display valuable insights into trainees’ thinking. We analyzed narratives from graduate students trained in aging themes, who then interviewed older hospitalized adults (senior partners) about their life experiences. Methods: Three Discovery & Learning Fellows trained on open-ended interviewing, empathy, and aging themes performed semi-structured interviews. Senior partners were hospitalized older veterans. After the [...]

by Christopher Wilson  , Anthenius Versluis  , Daranee Tantbirojn  and Martha Wells

Received: 10 February 2021;  Published: 28 May 2021;  doi: 10.21926/rpm.2102020

Prefabricated zirconia crowns (ZRCs) require a passive fit and more reduction than stainless steel crowns (SSC). To determine the mean and maximum reduction depths in the mesial-buccal and occlusal areas for three ZRC brands and one SSC in posterior primary typodont molars and to compare reduction depths to existing literature to determine the preparation’s proximity to pulpal tissue. Four primary maxillary and mandibular typodont teeth (J and S) were prepared according to the manufacturers’ guidelines for three ZR [...]

by Shalika B. Katugaha  , Oksana Shlobin  , Chris King  , Steve Nathan  , Shambu Aryal  , Kareem Ahmad  and Whitney Brown

Received: 04 September 2020;  Published: 13 October 2020;  doi: 10.21926/obm.transplant.2004120

Strongyloides stercoralis infection derived from the donor in solid organ transplant (SOT) places recipients at risk for hyperinfection syndrome and death. We describe the case of a lung transplant recipient who developed strongyloidiasis presenting with GI symptoms and progressing to diffuse alveolar hemorrhage, bacteremia and multi-organ failure. The patient's clinical course illustrates the life cycle of Strongyloides. For treatment, the patient received ivermectin and albendazole. We advocate that early diagnos [...]

by Stefan Klek  , Jonathan Newgren  , Philip Burns  , Angelika Kwak  , Eric Casinelli  , Tony Tu  , Theodote K. Pontikes  and Edwin Meresh

Received: 10 May 2023;  Published: 13 October 2023;  doi: 10.21926/obm.neurobiol.2304188

Neuroleptic Malignant Syndrome (NMS) and Malignant Catatonia (MC) are conditions with significant overlap and are classically characterized by autonomic dysfunction, rigidity, bradyreflexia, posturing, lead-pipe rigidity in the former and waxy flexibility in the latter, stereotyping, an increase in creatinine kinase, and/or leukocytosis. Onset after inciting factor ranges from days to weeks, as does resolution with appropriate treatment. The overlap in symptomatology with Autism spectrum disorder (ASD) presents a f [...]

by Leila Naseri  , Mohsen Akbaribazm  and Mozafar Khazaei

Received: 06 February 2024;  Published: 04 July 2024;  doi: 10.21926/obm.genet.2403248

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy causing non-ovulation infertility in women. Women with PCOS have higher levels of luteinizing hormone (LH), testosterone, cholesterol and triglycerides but, in contrast, lower levels of follicular stimulating hormone (FSH) and sex hormone-binding globulin (SHBG) compared with healthy counterparts. Because of the limitations of human studies, animal models of PCOS have been developed to identify appropriate therapeutics and to explore their mechanism [...]

by Chen-Wei Yang  , Min-Ze Lu  , Wei-Ming Ma  and Chang-Ming Liaw

Received: 23 December 2020;  Published: 07 April 2021;  doi: 10.21926/jept.2102016

This paper presents a three-phase full-bridge boost switch-mode rectifier (SMR) fed switched-reluctance motor (SRM) drive with energy storage buffer. First, the power circuits and control schemes of the two power stages are properly designed. Except for having good line drawn power quality, the boostable DC-link voltage of the SRM drive can enhance the SRM driving performance in wide speed range. And the recovered regenerative braking energy can be sent back to the grid successfully. Then, a battery storage system [...]