by Khalid Nawaz  , Iqra  , Muneeb Ullah  , Jin-Wook Yoo  , Umme Aiman  , Madiha Ghazanfar  and Muhammad Naeem

Received: 21 June 2024;  Published: 10 January 2025;  doi: 10.21926/rpn.2501002

The persistent inflammation of the intestinal mucosa is the main characteristic of inflammatory bowel disease (IBD), a lifelong illness that affects people of both genders. The exact etiology is still undefined while previously it was attributed to genetic components. Later, it was investigated that the environment has an equal effect on the development of IBD encompassing both Crohn’s disease (CD) and Ulcerative colitis (UC). Among environmental risk factors linked to IBD, diet, notably the transition toward the W [...]

by Collin J. Anderson  , Amanda C. Guidon  , Farrah B. Khan  , Alissa A. Thomas  , Carolyne Riehle  , Michael K. Hehir  and Noah A. Kolb

Received: 28 October 2020;  Published: 31 January 2021;  doi: 10.21926/obm.neurobiol.2101086

Lambert Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder involving loss of functional pre-synaptic P/Q-type voltage-gated calcium channels. Many cases occur as a paraneoplastic disorder, often in small cell lung cancer (SCLC). Recently, immune checkpoint inhibitors (ICI) have emerged as treatment of choice for various malignancies. While generally well tolerated, certain ICI-treated patients experience neurologic immune-related adverse events (irAEs). Here, we explore therapeuti [...]

by Xiaolei Liu  , Yanjie Zhang  , Xiru Du  , Yongzhi Ma  , Ruike Jiang  , Shihui Chen  and Yongtai Wang

Received: 24 September 2022;  Published: 28 January 2023;  doi: 10.21926/obm.icm.2301008

Qigong, a traditional Chinese exercise routine, has been used as a treatment for Parkinson’s disease (PD) in many studies, and the results have confirmed its effectiveness in reducing the symptoms of PD. However, no study has yet investigated the long-term effects and benefits of Qigong practices in improving the symptoms of PD. The purpose of this follow-up evaluation was to investigate the long-term effects of Qigong practices in improving the symptoms of PD. In this randomized controlled trial (RCT), patie [...]

by Peizeng Yang  , Yaye Wang  , Junhe Lu  , Viktor Tishchenko  and Qingguo Huang

Received: 02 November 2020;  Published: 29 December 2020;  doi: 10.21926/aeer.2004006

This study examined the degradation of perfluorooctanesulfonate (PFOS) in electrochemical oxidation (EO) processes in the presence of trichloroethylene (TCE). The EO experiment was performed in a gas-tight reactor using Magnéli phase titanium suboxide (Ti4O7) as the anode. The experimental data demonstrated that 75% of PFOS (2 μM) was degraded at 10 mA/cm2 current density in 30 min without TCE present in the solution, while the presence of 76 μM TCE apparently inhibited the degradation of PFOS, reducing its r [...]

by Ludmila Velichkina  , Yakov Barbashin  and Alexander Vosmerikov

Received: 10 October 2021;  Published: 01 December 2021;  doi: 10.21926/cr.2104004

The objective of this research was to analyze the effect of different concentrations of nitric and hydrochloric acids on the structural, acidic, and catalytic properties of a post-synthetic treated ZSM-5 type zeolite at various temperatures. The properties of zeolite catalysts were determined using different methods, such as the Brunauer-Emmett-Teller (BET) method for specific surface area, temperature-programmed desorption (TPD) of ammonia method for acidic properties, and a flow-through unit with fixed bed cataly [...]

by María Izal  , Roberto Nuevo  and Ignacio Montorio

Received: 19 June 2019;  Published: 12 December 2019;  doi: 10.21926/obm.geriatr.1904094

Background: In the last two decades, successful aging (SA) and positive psychology (PP), the two paradigms of health have received great attention. They originate from different approaches, theoretical background, and objectives. Although they share many characteristics, their association remains understudied. This article aims to empirically analyze their possible interrelation. Methods: In this cross-sectional study, 169 healthy, old adults completed several questionnaires to assess the central framework for succ [...]

by Shefali Mody  , Soham Nadkarni  , Shreyash Vats  , Akshay Kumar  , Sravanthi Nandavaram  and Suresh Keshavamurthy

Received: 09 July 2023;  Published: 23 November 2023;  doi: 10.21926/obm.transplant.2304203

The shortage of donor lungs for transplantation is a major challenge, resulting in longer waitlist times for patients with a higher risk of waitlist mortality. It is crucial to continue promoting awareness about organ donation through legislation, public campaigns, and health care provider education. Only a small number of cadaveric donors meet the ideal criteria for lung donation, leaving many lungs unused. Donor lung utilization can be improved by carefully considering the extended-criteria donors, actively parti [...]

by Wangkuk Son  , Jason Lin  and Melissa Puppa

Received: 28 September 2020;  Published: 07 December 2020;  doi: 10.21926/obm.icm.2004044

Cancer cachexia contributes to 30% of cancer-related deaths. There is currently no treatment or standard of care for cancer cachexia. Many nutritional interventions show promise for the treatment and or prevention of cachexia. Supplementation with omega-3 fatty acids, protein and vitamins either alone or in combination has shown some beneficial effects in the prevention and treatment of cancer cachexia. The mechanisms through which many nutritional interventions work to attenuate cachexia are just beginning to be u [...]

by Cristóbal Coronel-Rodríguez  and Alejandro Rodríguez-Martínez

Received: 07 May 2020;  Published: 17 July 2020;  doi: 10.21926/obm.neurobiol.2003066

Gluten-related disorders (GRDs) represent a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. The most common and widely recognized diseases within this spectrum are celiac disease and non-celiac gluten sensitivity. The clinical manifestations are intestinal, but extraintestinal manifestations may also appear, such as neurological or psychiatric. This work will specifically review the neurological or psychiatric manifestations that are more freq [...]

by Christin Deal  , Kara Coffey  and Hey Chong

Received: 02 June 2023;  Published: 04 August 2023;  doi: 10.21926/obm.genet.2303190

Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) has been successfully implemented in all 50 United States and Puerto Rico from 2008-2018. This life-saving screening tool has drastically improved overall survival of babies diagnosed with SCID from 74% to 96%. TREC is a stable, circular DNA molecule that is produced during the process of T-cell receptor (TCR) rearrangement and is the target of the quantitative PCR screen on Guthrie cards. Low TRECs are a marker of low naive T cell numbers. This ne [...]

by Peng Li  , Chi-Yao Chang  and Amsini Sadiki

Received: 02 April 2021;  Published: 28 June 2021;  doi: 10.21926/jept.2102026

A numerical model describing the ballistic behavior of a commercially used initiator is presented in this article. This model was built on the principle of conservation of mass and energy in the multi-phase framework incorporated with multi-loaded conditions. After obtaining the information about the grain size distribution in each composite, a fixing factor was proposed based on the surface area ratio of the composites. Thus, the solid propellant burning process based on distributed grain size was described, and t [...]

by Vinayak Kaushal  and Mohammad Najafi

Received: 20 April 2022;  Published: 30 June 2022;  doi: 10.21926/aeer.2202027

Microbiologically influenced corrosion (MIC) of concrete in sanitary sewer pipe and manholes is the result of dilute sulfuric acid (H2SO4) dissolving the cement matrix. The acid is produced by a complex series of chemical and biochemical reactions. The objectives of this paper are: (1) to review the basic science of the MIC process starting with the various biological processes leading to the production of dilute sulfuric acid; (2) to discuss historical attempts to fortify concrete; (3) to present methods to reduce [...]

by Jaspreet Kaur  , Khushveer Kaur  , Khushwinder Kaur  , Avtar S. Matharu  and Surinder K. Mehta

Received: 14 December 2022;  Published: 14 April 2023;  doi: 10.21926/aeer.2302027

Continued industrialization, urbanization and ecological destruction have caused significant environmental problems, particularly increased water pollution. Introducing harmful organic and inorganic effluents into watercourses has limited the supply and accessibility of safe and affordable drinking water. There is an urgent need to find green and sustainable abatement solutions for water remediation, many based on nanoparticles. The primary objective of this review is to explore and have a comprehensive discussion [...]

by Nobuyuki Imanishi  , Tao Zhang  , Daishuke Mori  , Sou Taminato  , Yashuo Takeda  and osamu yamamoto

Received: 21 February 2021;  Published: 08 May 2021;  doi: 10.21926/jept.2102019

Because lithium metal exhibits high specific capacity and low potential, it is the best candidate for fabricating anodes for batteries. Rechargeable batteries fabricated using lithium anode exhibit high capacity and high potential cathode; these can be potentially used to fabricate high energy density batteries (>500 Wh kg-1) that can be used for the development of next-generation electric vehicles. However, the formation and growth of lithium dendrites and the low coulombic efficiency recorded during lithiu [...]

by Darcy L. Harris

Received: 26 August 2023;  Published: 16 November 2023;  doi: 10.21926/obm.icm.2304052

In the past several decades, new understandings about grief have emerged. In the same time frame, a substantial body of literature has explored the components of compassion and their potential application to various clinical contexts. Compassion evolved from caring motivation associated with the evolutionary challenges of reproduction that involved the necessary care for offspring. Grief also has an evolutionary background that is rooted in core aspects of attachment and the assumptive world construct. Compassion F [...]

by Ki-Won Jeong  , Jeong Chan Kim  and In-Sung Luke Yeo

Received: 13 August 2020;  Published: 17 December 2020;  doi: 10.21926/rpm.2004024

A connection structure using both a screw and friction is advantageous to secure an abutment to an implant. Understanding the biomechanics of the implant-abutment connection is necessary for the long-term clinical survival of a dental implant with decreased complications. The internal conical friction connection structure and micro-threads have shown favorable biological hard tissue response with exceptional structural features. The internal conical connection structure maintains the soft tissue seal and the margin [...]

by Natasha Hui Jin Ng  , Wei Xuan Tan  , Ye Xin Koh  and Adrian Kee Keong Teo

Received: 11 March 2019;  Published: 21 June 2019;  doi: 10.21926/obm.transplant.1902068

The ability to routinely and reproducibly obtain purified human islets has facilitated substantial progress in providing a safe and reliable treatment option for adult patients of type 1 diabetes. The availability of human islets for basic research has also significantly improved the understanding of the biology of human islets, and consequently the pathophysiology of diabetes. Presently, about 70 human islet isolation centers are known to exist around the world, in addition to multiple coordinated human islet dist [...]

by Rosita Borlimi  , Greta Riboli  , Mattia Nese  , Matilde Buattini  , Marella Colombardo  and Gianni Brighetti

Received: 07 November 2021;  Published: 01 April 2022;  doi: 10.21926/obm.icm.2202014

The length of the menstrual cycle (MC) varies among women, with an average regularity between 21 and 40 days. Six temporal frames can be observed within the monthly cycle, based on the fluctuations of the hormone levels. These fluctuations are accompanied by alterations in the central nervous system (CNS) and autonomic nervous system (ANS) and can be quantified using psychophysiological techniques. In this systematic review, we discussed the studies conducted with healthy females that examined aspects associated wi [...]

by Roland Pässler

Received: 17 June 2021;  Published: 22 November 2021;  doi: 10.21926/rpm.2104042

The well-known classical heat capacity model developed by Debye proposed an approximate description of the temperature-dependence of heat capacities of solids in terms of a characteristic integral, the T-dependent values of which are parameterized by the Debye temperature, ΘD. However, numerous tests of this simple model have shown that within Debye's original supposition of approximately constant, material-specific Debye temperature, it has little chance to be applicable to a larger variety of non-metals, e [...]

by Maurizio Gabrielli  , Veronica Ojetti  , Marcello Candelli  , Luca Santarelli  , Antonio Gasbarrini  and Francesco Franceschi

Received: 18 August 2020;  Published: 09 February 2021;  doi: 10.21926/obm.neurobiol.2101087

Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcificat [...]

by Andreea L. Seritan

Received: 31 July 2023;  Published: 24 October 2023;  doi: 10.21926/obm.geriatr.2304254

Climate change is a major public health emergency. Natural disasters (earthquakes, floods, hurricanes, tornadoes, tsunamis, landslides, wildfires, and volcanic eruptions) have been increasing in frequency and severity and can cause lasting psychological sequelae. Older adults are highly vulnerable to the physical and mental health impacts of extreme weather and natural disasters. A narrative review was conducted to identify and summarize English-language articles focusing on the impact of climate change on older ad [...]

by Alexander Henn  and Maija-Liisa Mattinen

Received: 08 March 2019;  Published: 26 April 2019;  doi: 10.21926/rpm.1902001

Technical lignins from the biorefinery, pulp, and paper industries are largely underutilized, even though this aromatic and randomly structured biopolymer could be an interesting raw material for advanced applications in addition to bulk daily goods. Recently, colloidal lignin particles (CLPs) have gained much of the research interests due to the attractive multi-functional properties of the biopolymer. Utilization of lignin in nanoparticulate morphology resolves most of the drawbacks when using lignin (heterogenei [...]

by Onix Cantres-Fonseca  , Shambhu Aryal  , Christopher King  and Steven D. Nathan

Received: 25 May 2023;  Published: 20 February 2024;  doi: 10.21926/obm.transplant.2401207

Chronic allograft dysfunction (CLAD) is one of the leading causes of death after lung transplantation [1]. CLAD is a progressive and irreversible decline in lung function after transplant, manifested as an obstructive, restrictive, or mixed ventilatory impairment without any identifiable etiology as infection or acute rejection. Multiple risk factors have been associated with this condition. Despite its significant effect on the mortality of transplanted patients, there is still a lack of powerfully effective thera [...]

by Sima Farpour  , David Smithard  and Hamid reza Farpour

Received: 14 November 2019;  Published: 20 February 2020;  doi: 10.21926/obm.geriatr.2001109

Dysphagia is a term that is used for the difficulty in moving liquid/food from mouth to the stomach. Dysphagia is very common in elders, which makes them susceptible to malnutrition, infection, institutionalization, and death. Consequently, it is categorized as a geriatric syndrome. Therefore, multidisciplinary teams need to work together to determine the correct etiology and implement an appropriate care plan. Oral care is crucial in managing dysphagia and dental hygienists and dentists serve as the key members. I [...]

by Andrew G.L. Douglas  and Diana Baralle

Received: 31 December 2020;  Published: 08 March 2021;  doi: 10.21926/obm.genet.2101125

A large proportion of rare disease patients remain undiagnosed and the vast majority of such conditions remain untreatable whether diagnosed or not. RNA splicing analysis is able to increase the diagnostic rate in rare disease by identifying cryptic splicing mutations and can help in interpreting the pathogenicity of genomic variants. Whilst targeted RT-PCR analysis remains a highly sensitive tool for assessing the splicing effects of known variants, RNA-seq can provide a more comprehensive transcriptome-wide analy [...]