by Lindy A. Kilik  and Robert W. Hopkins

Received: 01 March 2019;  Published: 09 May 2019;  doi: 10.21926/obm.geriatr.1902052

Background: Clinical studies have shown that caregivers of dementia patients often experience a great deal of stress related to caregiving. This paper examines caregiver stress within the context of behaviour change in dementia using the Kingston Caregiver Stress Scale (KCSS) and the Kingston Standardized Behaviour Scale (Community Form) (KSBA(comm)). Methods: Eighty patients with moderate dementia and their caregivers participated. Each patient was cognitively assessed with the Kingston Standardized Cognitive Asse [...]

by Antonio Meola

Received: 05 May 2019;  Published: 08 May 2019;  doi: 10.21926/obm.neurobiol.1902025

by Gian Andrea Rollandi  , Aldo Chiesa  , Nicoletta Sacchi  , Mauro Castagnetta  , Matteo Puntoni  , Adriana Amaro  , Barbara Banelli  and Ulrich Pfeffer

Received: 31 January 2019;  Published: 05 May 2019;  doi: 10.21926/obm.geriatr.1902051

Aging is associated with an increased incidence of major diseases, including cancer, cardiovascular, neurodegenerative, metabolic and autoimmune diseases. Primary prevention and early diagnosis of these diseases have a dramatic impact on incidence, outcome, quality of life and are commonly applied as age-dependent indications based on evidence of efficacy for specific groups of the aging population. They likely contribute to the observed increase in life expectancy through the reduction of incidence and the retarda [...]

by Yuri B. Yurov  , Svetlana G. Vorsanova  and Ivan Y. Iourov

Received: 06 February 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902076

The human brain has been repeatedly shown to exhibit intercellular/somatic genomic variations at the chromosomal level, which are involved in the neuronal diversity in health and disease. Brain-specific chromosomal mosaicism (aneuploidy) and chromosome instability play a role in the normal and pathological neurodevelopment, neurodegeneration and aging of the central nervous system. Regardless of achievements in somatic cell (single-cell) genomics, there is still no consensus on the amounts of chromosomally abnormal [...]

by Kristi Kanel

Received: 30 January 2019;  Published: 30 April 2019;  doi: 10.21926/obm.icm.1902030

While it may seem intuitive to suggest that compassion aids in the healing process, there is actual evidence to support that compassion changes physiology, which in turns affects emotional and physical healing. The focus of this opinion paper is on the use of compassion between health care providers and patients based on the use of compassion in the mental health field. Not only do patients benefit from compassion, but health care providers may also benefit. Creating compassionate relationships with patients may [...]

by Marcel Mannens

Received: 24 April 2019;  Published: 30 April 2019;  doi: 10.21926/obm.genet.1902075

none

by Rita Payan-Carreira

Received: 30 December 2018;  Published: 29 April 2019;  doi: 10.21926/obm.genet.1902074

In a mammal, at the beginning of its development, the gonad is bipotential. The shift into a male or female pathway is coordinated by the sex chromosomal complement, which triggers a series of genetic pathways signaling the developmental pattern of the gonadal anlage. Being mutually exclusive, the differentiated gonad should be either a testis or an ovary. In females, the absence of SRY, a testis-determining gene, drives the signaling cascades controlling the ovarian differentiation. Albeit rare, disorders of the g [...]

by Mariella Di Stefano  , Sonia Baccetti  , Elio Rossi  , Maria Valeria Monechi  , Barbara Cucca  , Sergio Segantini  , Elisabetta Barbara Cortesi  , Fabio Voller  , Eleonora Fanti  , Alice Berti  and Stefano Bravi

Received: 27 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902029

Background: According to the international literature, users of Complementary Medicine (CM), Complementary and Alternative Medicine (CAM) and Complementary and Integrative Medicine (CIM) are physically more active, less overweight and have healthier lifestyles than the average Tuscan population. Aim: To evaluate the socio-demographic characteristics and lifestyles of patients of CM public clinics in the region of Tuscany and to define their profiles in terms of physical exercise, smoking habits, diet, intake of alc [...]

by Elisabetta Barbara Cortesi  , Sonia Baccetti  , Maria Valeria Monechi  , Mariella Di Stefano  , Barbara Cucca  , Tommaso Conti  , Antonella Traversi  , Filippa Terranova  , Roberto Montelatici  , Sylvie Yvonne Barberousse  , Federica Sabatini  , Catia Vuono  , Christian Bini  and Marco Picchi

Received: 26 September 2018;  Published: 28 April 2019;  doi: 10.21926/obm.icm.1902028

Introduction: Pain in musculoskeletal disorders is a common problem that involves high social and individual costs. Systematic reviews and randomized controlled trials show that a number of treatments usually applied in this field are not effective. On the other hand, there is clinical evidence of the effectiveness of physical exercise, acupuncture, and auriculotherapy. Side effects of current medication limit their use. Aim: To evaluate the effectiveness of auriculotherapy on the pain of patients suffering from ch [...]

by Alexander Henn  and Maija-Liisa Mattinen

Received: 08 March 2019;  Published: 26 April 2019;  doi: 10.21926/rpm.1902001

Technical lignins from the biorefinery, pulp, and paper industries are largely underutilized, even though this aromatic and randomly structured biopolymer could be an interesting raw material for advanced applications in addition to bulk daily goods. Recently, colloidal lignin particles (CLPs) have gained much of the research interests due to the attractive multi-functional properties of the biopolymer. Utilization of lignin in nanoparticulate morphology resolves most of the drawbacks when using lignin (heterogenei [...]

by Claire Thompson  , Daniela Calafiore  , Julijana Chochovski  , Steven Trawley  and Kathryn von Treuer

Received: 29 October 2018;  Published: 26 April 2019;  doi: 10.21926/obm.geriatr.1902050

Background: The increasing numbers and proportion of the ageing population make it essential to develop and evaluate programs to meet the needs of older adults to empower them to age actively, healthily and successfully. Consequently, positive ageing programs have been developed and the need to evaluate their outcomes is essential. This study used mixed methods to evaluate cognitive and behavioural changes and to monitor psychological health and active ageing in participants of a longstanding positive ageing psycho [...]

by Masaaki Takamura  and Shuji Terai

Received: 04 February 2019;  Published: 25 April 2019;  doi: 10.21926/obm.hg.1902018

In cirrhosis, portal hypertension and hypoalbuminemia due to decreased albumin synthetic capacity and hormonal imbalance due to increased renin-angiotensin-aldosterone and vasopressin systems cause fluid retention and electrolyte abnormalities. Diuretics are indispensable for the control of body fluid volume in liver cirrhosis, and aldosterone antagonists and loop diuretics have been widely used until now. In Japan, tolvaptan, a vasopressin V2 receptor antagonists, became available in September 2013, expanding trea [...]

by Peter Lechleitner

Received: 02 March 2018;  Published: 25 April 2019;  doi: 10.21926/obm.icm.1902027

The first part of this position paper focuses on the debate about the scientific status of homeopathy and presents some answers. The scientific debate however, does not represent the available scientific evidence, which actually supports our limited data. Thus, it seems important and we aim to present how homeopathy can be part of an integrated concept in cancer care and how this is approved by randomized controlled trials. We present some arguments which were helpful to us in the discussion with oncologists that d [...]

by Gila Chen

Received: 04 March 2019;  Published: 24 April 2019;  doi: 10.21926/obm.icm.1902026

Background: A large body of empirical evidence has supported the notion that individuals with substance use disorders (SUDs) have difficulty regulating their negative emotions and employing emotion-regulation strategies. The aim of this article is to (a) explore the role of self-compassion in providing an emotion-regulation strategy for initiating a process of recovery from SUDs; (b) examine the role of self-compassion in building recovery capital (RC) to promote long-term recovery; and (c) examine the practice of [...]

by Keith A. Wollen  and John W. Hoyt

Received: 15 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902048

Background: Cognitive abilities in Alzheimer’s Disease are usually examined by formal tests conducted in a laboratory or facility. Such tests are useful for determining the severity of the disease but do not indicate the types of cognition exhibited in the daily lives of patients. This study shows significant preservation of cognition and quality of life in the daily routine of a woman with severe Alzheimer’s who was given multiple therapeutic interventions. Alzheimer’s disease involves multiple d [...]

by Michael P. Cary  , Valerie A. Smith  , Megan Shepherd-Banigan  , Jennifer H. Lindquist  , Jennifer G. Chapman  , Susan N. Hastings  and Courtney H. Van Houtven

Received: 22 February 2019;  Published: 18 April 2019;  doi: 10.21926/obm.geriatr.1902049

Background: Moderator analyses may be helpful for evaluating intervention effects. The objective of this study was to evaluate whether the effect of a caregiver skills training intervention – Helping Invested Families Improve Veterans' Experience Study (HI-FIVES) – on care recipient outcome and caregiver outcome is moderated by the veteran’s risk for hospitalization or level of functional impairment. Methods: Secondary data analysis of HI-FIVES. Outcomes included veteran days in the community (cumulative days in th [...]

by Robert T. Rubin

Received: 14 March 2019;  Published: 18 April 2019;  doi: 10.21926/obm.icm.1902025

There are several definitions of sympathy, empathy, and compassion on the internet. I have chosen the above definitions to emphasize their salient differences, for the following reason: In medical school, in the early 1960s, we were taught not to sympathize with patients, but to empathize: By empathizing, one can retain some professional objectivity toward the patient, in order to be of some help. To sympathize, on the other hand, was to immerse oneself in the patient’s suffering and lose one’s professional per [...]

by Racha El-Hajj Ghaoui  , Dorothy Hung  and Bhavna Padhye

Received: 24 December 2018;  Published: 17 April 2019;  doi: 10.21926/obm.genet.1902073

Hypodiploidy has a low incidence in childhood acute lymphoblastic leukaemia (ALL). Patients are usually stratified into three subgroups, to allocate the correct treatment according to their ploidy level: high hypodiploidy (40-45 chromosomes), low hypodiploidy (33-39 chromosomes) and near haploidy (23-29 chromosomes). In this paper, a case is presented of near-haploid childhood ALL where fluorescence in situ hybridisation (FISH) provided an insight into the near-haploidy chromosomal aberration initially missed on ro [...]

by Joseph V. Pergolizzi, Jr.  and Jo Ann LeQuang

Received: 13 November 2018;  Published: 17 April 2019;  doi: 10.21926/obm.geriatr.1902047

As the 80 million “baby boomers” reach retirement, they bring their relaxed attitudes toward drug use to create a clinically significant population of geriatric drug abusers. Opioid use disorder (OUD) brings with it special considerations in the elderly population: age-related changes to drug disposition, brain changes in the elderly, polypharmacy, and the likelihood of comorbid conditions (such as cardiovascular or pulmonary diseases) and pain syndromes. Thirteen percent of patients in a New York city methadone cl [...]

by Simonetta Bernardini  , Francesca Bechini  , Giulia Braccesi  , Franco Cracolici  , Rosaria Ferreri  , Roberto Pulcri  and Andrea Serafini

Received: 30 September 2018;  Published: 17 April 2019;  doi: 10.21926/obm.icm.1902024

Since 2011, the Tuscany Regional Authority has been funding the use of Integrated Medicine (IM) in a clinical setting in Pitigliano Hospital, with the aim of testing the true efficacy of complementary and alternative medicine (CAM) in a hospital setting. The clinical setting also comprises the Manciano rehabilitation facility whose services include post-stroke rehabilitation. This study aims to establish if IM helps to improve the rehabilitation performance of stroke patients. The study compared 212 patients divide [...]

by Michael Frass  and Katharina Gaertner

Received: 16 January 2019;  Published: 16 April 2019;  doi: 10.21926/obm.icm.1902023

This case reports of a 71-year-old patient with polycythemia vera (PCV). Homeopathic treatment began 15 years after his diagnosis at the age of 51. The frequency of phlebotomies was lowered significantly after the start of the homeopathic treatment; the patient survived another 16 years without chemotherapy, which he had rejected despite appropriate education. For someone with PCV who denied chemotherapy, this patient had a long survival time of more than 30 years, essentially enjoying good health and high quality [...]

by Gianluca Donatini  , Sébastien Giraud  , Jean-Louis Kraimps  , Jérôme Danion  and Thierry Hauet

Received: 08 April 2019;  Published: 15 April 2019;  doi: 10.21926/obm.transplant.1902062

Pancreatic islet transplantation represents an effective therapy with lower morbidity for patients carriers of type 1 diabetes compared to whole pancreas transplantation. Although complete insulin independence is usually not achieved it allows control of glycemia balance reducing the risk of severe hypoglycaemia events and impaired awareness of hypoglycaemia. Recent trials had demonstrated islet transplantation to be more effective than current medical treatment and improvements in outcomes also have been reported [...]

by Raffaele Pezzilli

Received: 07 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.hg.1902017

Acute pancreatitis still represents a challenge for physicians; it ranges from mild self-limiting forms Walled-off necrosis (WON), previously called by other names, such as organized pancreatic necrosis, necroma, pancreatic sequestration, pseudocyst associated with necrosis and subacute pancreatic necrosis is a new entity of complications of acute pancreatitis. It is defined as a mature, encapsulated collection of pancreatic and/or peripancreatic necrosis which has developed a well-defined inflammatory wall. WON us [...]

by Katia Belvedere  , Elio Rossi  , Mariella Di Stefano  and Sonia Baccetti

Received: 22 February 2019;  Published: 10 April 2019;  doi: 10.21926/obm.icm.1902022

Complementary Medicine (CM) is being increasingly used by European citizens in order to increase their overall state of health and well-being, as well as to treat various illnesses and diseases. The interest for these therapies has progressively risen also in Italy and in Tuscany as well. In response to the increasing demand in the past few years by the Tuscan citizens, the region of Tuscany has started their integration in the healthcare service. Since 1996, the Tuscan Regional Healthcare Plans (RHPs) have been co [...]

by Richard Cheng  and Jon Kobashigawa

Received: 23 January 2019;  Published: 09 April 2019;  doi: 10.21926/obm.transplant.1902061

Cardiac allograft vasculopathy (CAV) limits long-term survival after heart transplantation. CAV with discrete or tubular lesions can be treated with percutaneous coronary intervention (PCI) with high procedural success. Revascularization with balloon angioplasty, bare-metal stents, and first-generation drug-eluting stents has been associated with high and unacceptable restenosis rates. However, second-generation drug-eluting stents are associated with favorable stent and lesion patency. Stent and lesion patency now [...]