by Jiani Yin  , David Oleson  and Christian P. Schaaf

Received: 31 August 2017;  Published: 24 February 2018;  doi: 10.21926/obm.genet.1801014

Autism spectrum disorder is a clinically heterogeneous condition, characterized by social deficits, language impairment, repetitive behaviors, and restricted interest. Autism displays significant genetic heterogeneity. In the past one and a half decades, next generation sequencing has enabled identification of many variants that predispose to autism. These discoveries have improved understanding of the disease etiology of autism spectrum disorder. In this review article, we will address how development of next gene [...]

by Angharad Vernon-Roberts  and Andrew S Day

Received: 23 January 2022;  Published: 19 April 2022;  doi: 10.21926/rpn.2202013

Children with inflammatory bowel disease (IBD) have a high prevalence of vitamin D insufficiency secondary to factors such as malabsorption and decreased intake. In recent years the benefits of optimal vitamin D status have been highlighted for their potential to improve the disease course and long-term outcomes in this population. Clinical benefits have been seen to bone health, the immune system, and gut health, with further improvements to disease and treatment outcomes. Recommendations for vitamin D treatment p [...]

by Lei Zhang  , Xian-Zhang Hu  , Xiaoxia Li  , Jacob Dohl  , Tianzheng Yu  and Robert J. Ursano

Received: 28 December 2018;  Published: 21 March 2019;  doi: 10.21926/obm.geriatr.1901041

Depression, PTSD, and hostility are common mental conditions that are associated with aging. A growing body of research has highlighted the possible effects of depression, PTSD, and hostility on aging and telomere length (TL), a cellular aging marker. Individuals who exhibit excessive responses to stressors show notable circulating inflammatory responses with high cortisol reactivity, which increases cell turnover and oxidative stress and may subsequently contribute to shortened TL. This review focuses on the most [...]

by Ghazaleh Ramezani  , Theo G. M. van de Ven  and Ion Stiharu

Received: 20 September 2024;  Published: 21 January 2025;  doi: 10.21926/rpm.2501004

This study investigates the hypothesis that diverse synthesis techniques can yield cellulose-graphene hybrids with tailored properties for specific applications, enabling advancements in flexible electronics, energy storage, environmental remediation, and biomedical devices. We examined and compared multiple synthesis methods, including chemical reduction, in-situ synthesis, green synthesis using natural reducing agents, solvent-assisted approaches, hydrothermal and solvothermal techniques, mechanical and chemical [...]

by Vardan Apinyan  and Mane Sahakyan

Received: 17 March 2020;  Published: 01 July 2020;  doi: 10.21926/rpm.2003016

The present report provides a phenomenological theory for monolayer graphene, in which two worlds, the quantum and the classical, meet and complete each other in the most natural manner. In the present report, electron mass-vortex representation is introduced, and the surface tension excitation states in the monolayer graphene are defined. The band-mass of the electrons at the Dirac’s point was calculated through the mathematical introduction of a mass-dispersion relation. As a consequence, the Dirac’s [...]

by Naiwei Chi  , Shuyao Zheng  , Elwin Clutter  and Rong Wang

Received: 30 October 2019;  Published: 18 December 2019;  doi: 10.21926/rpm.1904007

Background:Diabetic patients suffer from chronic wounds partly due to altered function of fibroblasts. Fibroblasts of diabetic patients synthesize collagen I (COLI) at a much higher level than collagen III (COLIII), resulting in delayed tissue granulation and, consequently, a delay in the overall wound healing process. Methods:We aimed to revive the matrix protein productivity of diabetic fibroblasts by employing aligned, electrically conductive and biocompatible spider silk-CNT fibers as a cell culture matrix to m [...]

by Arksarapuk Jittirat  , Natsuki Eguchi  , Natthavat Tanphaichitr  , Myreen Tomas  , Praveen Gundelly  , Kai Zhao  , Leal Herlitz  , Yasolatha Chalicheemala  , Himabindu Yerneni  , Rachel C. Forbes  , Beatrice P. Concepcion  and Ekamol Tantisattamo

Received: 02 May 2021;  Published: 07 February 2022;  doi: 10.21926/obm.icm.2201007

The novel coronavirus disease 2019 (COVID-19) pandemic has significantly impacted kidney transplantation worldwide. The rate of kidney transplantation decreased during the peak of the COVID-19 pandemic, especially living donor kidney transplantation. Kidney transplant recipients are at high risk of developing severe complications from COVID-19 due to underlying comorbidities and immunosuppressed status. Management of immunosuppression, including the induction therapy and maintenance immunosuppressive regimen, has b [...]

by Melissa Sandler  , Sulaiman Almohaish  and Gretchen M. Brophy

Received: 11 February 2021;  Published: 16 March 2021;  doi: 10.21926/obm.geriatr.2101161

Pharmacological management of intracerebral hemorrhage in adult patients over 65 years of age requires special considerations due to differing clinical presentations, underlying organ dysfunction, and more complex medical histories and medication profiles. A literature review of articles focusing on the age-specific pharmacological management of intracerebral hemorrhage was conducted. Treatment approaches and clinical outcomes specific to older adults were evaluated and therapeutic considerations for this populatio [...]

by Zoi Portokalidou  , Anna Huysse-Gaytandjieva  and Madelon L. Peters

Received: 09 January 2022;  Published: 12 July 2022;  doi: 10.21926/obm.icm.2203027

Hashimoto thyroiditis (HT) is an autoimmune disease affecting mainly middle-aged women. Hormonal replacement is the most common therapy; however, it tackles only the functionality of the thyroid and not the autoimmunity components. Thus, patients experience persistent somatic and psychological symptoms, thereby affecting their quality of life. The cause of HT remains uncertain. Primary evidence suggests that adverse experiences in childhood are associated with autoimmune disease manifestation in adulthood; therefor [...]

by Rachel Snodgrass  , Joanna Carnell  and Tim Chapman

Received: 31 May 2022;  Published: 10 August 2022;  doi: 10.21926/obm.icm.2203035

This study presents a mixed methods evaluation of a transdiagnostic Compassion Focused Therapy (CFT) group intervention, for adults with long-term health conditions (LTHCs). It aims to assess whether group completion was associated with improved outcomes in mood, overall well-being and the extent of LTHC interference in confidence for managing daily activities. Additionally, it examines the extent to which changes were related to processes targeted by CFT. The ‘Living Well with Illness’ group consisted of eleven we [...]