Behavioral Disorders and Celiac Disease: Coincidence or Casualty?Abstract
This paper presents the case of a child diagnosed with both celiac disease and Asperger’s syndrome. The literature does not report this association to date, and the authors believe it to be a coincidence rather than a casualty. 1781 12607 |
Brief Review: Pancreatic Islet Transplantation for Type 1 Diabetes in HumansAbstract
Pancreatic islet transplantation (ITx) has moved from the experimental phase of development to a position of an accepted and appropriate procedure to apply in clinical medicine. The primary indication for use of ITx is for management of dangerous and recurrent hypoglycemia secondary to use of exogenous insulin for management of hyperglycemia in people with type 1 diabetes. ITx involves procurement of a pancreas donated by a person who has died. The organ is taken to a specialized laboratory for isolation of islets [...] 1222 12607 |
Building New Nuclear in Finland: Crises Challenging Core Beliefs around Nuclear EnergyAbstract
This paper examines the building of a new nuclear plant as a greenfield operation in Pyhäjoki, Finland. A newly-founded energy company, Fennovoima, was granted a license by the Finnish parliament to build a new power plant in 2010. In the years following this Decision in Principle the project faced several obstacles. Through interviews with key actors, this paper identifies the interests and core beliefs associated with building the plant. It posits that, in Finland, the underlying ideas and values surrounding nucl [...] 1333 12604 |
Diet and Prevention of Cardiovascular DiseaseAbstract
Promoting a healthy diet is an effective strategy for preventing cardiovascular disease (CVD). The characteristics of a healthy diet are known. However, an unhealthy diet has become a significant contributor to the global burden of diseases, mainly due to its effect on CVD, diabetes, and cancer. A healthy diet is not accessible and affordable to most people worldwide. Marketing influences food choices and promotes unhealthy diets that contribute to obesity, CVD, diabetes mellitus, and cancer. Governments are respon [...] 1771 12600 |
Connections between Early-Life Neuroinflammation, Neural Stem Cells and Progenitors and Origins of Neuropsychiatric DisordersAbstract
A number of studies have highlighted the connection between infections during pregnancy in mothers and increased risk for neuropsychiatric disorders later in life leading to the view that maternal immune activation is a significant contributor to psychiatric illnesses. Meta-analyses have revealed associations between the incidence of premature birth and perinatal inflammation with smaller total brain volumes, cognitive, motor and behavioral deficits in childhood and adolescents. In animal studies where inflammati [...] 1817 12599 |
Design Guidelines to Reduce Extrinsic Fall Risks in the Built EnvironmentAbstract
As people age, environments supporting changing needs can potentially impact their quality of life. Aging often leads to a decrease in the ability of people to interpret sensory cues within their environment. Using Pastalan's Empathic Model as a framework, a list of guidelines for the physical environment was established to address the extrinsic risk factors affecting falls. Attention to these items may not prevent all falls but will mitigate some of the external risks that cause falls for older adults.
It is the g [...] 1610 12596 |
Experimental Study of Lean-burning Limits of Hydrogen-enriched LPG Intended for Domestic UseAbstract
The lean-burning limits of hydrogen-enriched Liquefied Petroleum Gas (LPG) have been studied using a Bunsen burner. The lean-burning limits under different conditions are important design considerations in developing gas-fired domestic appliances. In this study, the lean-burning limits of hydrogen-enriched LPG have been obtained across a wide range of Reynolds numbers (600 to 1800) and H2 volumetric fractions (0% to 25%). The results show that the lean-burning limit is increased, on average, by 4.0% to 7.2% for eve [...] 2354 12594 |
Characterisation of Oxidative Stress, DNA Damage and Inflammation in a Cellular Model of Parkinson’s Diseaseby
Alina Khan
,
Tengfei Wan
,
Catherine Hunter
,
Pavel Schweizer
,
Abbas Ishaq
,
Shobha Nagarathanam
,
Julia Morris
,
Minyu Chan
and
Gabriele Saretzki
Abstract
Background: Parkinson's disease (PD) is the second most common neurodegenerative disease and is a synucleinopathy due to the critical role of α-synuclein (α-Syn) in its pathology. α-Syn is able to translocate from the cytoplasm to the nucleus and cause DNA damage.
Methods: SH-SY5Y cells were stably transfected with plasmids containing wild type (WT) α-Syn and A53T mutant α-Syn as fusion proteins with EGFP and an EGFP only control vector. The cells were differentiated using retinoi [...] 1894 12593 |
Studying the Cognitive and Behavioural Dynamics of PsychopathyAbstract
The relevance of studying the cognitive and behavioral dynamics of psychopathy lies in its importance for improving diagnosis, therapeutic interventions, and reducing crime, thereby contributing to public safety. This study aimed to investigate how cognitive and behavioral mechanisms influence psychopathy. A combination of methods was employed, including the Levenson Self-Report Psychopathy Scale, semi-structured interviews, and the analysis of non-verbal reactions. The sample consisted of eight participants (four [...] 1050 12585 |
Ischemic Brain Injury and Regulatory T CellsAbstract
Inflammation and immune responses after stroke, including ischemic cerebral infarction, play pivotal roles in the pathology, resolution of inflammation, and neurological recovery. Regulatory T (Treg) cells are the cells responsible for immune tolerance, usually activated by secondary lymphatic tissues, which subsequently regulate effector T cell activation and dendritic cell activation. Recently, Tregs that are present in tissues, called tissue Tregs, have been shown to exhibit tissue-specific functions in addition [...] 1763 12582 |
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